MCID: MDS019
MIFTS: 29

Mediastinal Malignant Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Mediastinal Malignant Lymphoma

MalaCards integrated aliases for Mediastinal Malignant Lymphoma:

Name: Mediastinal Malignant Lymphoma 12 15
Lymphoma of Mediastinum 12
Mediastinal Lymphoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:6868
NCIt 50 C6633
UMLS 70 C1334665

Summaries for Mediastinal Malignant Lymphoma

MalaCards based summary : Mediastinal Malignant Lymphoma, also known as lymphoma of mediastinum, is related to hodgkin's lymphoma, lymphocytic-histiocytic predominance and lymphoblastic lymphoma. An important gene associated with Mediastinal Malignant Lymphoma is KDM4C (Lysine Demethylase 4C), and among its related pathways/superpathways are NF-kappaB Signaling and Primary immunodeficiency. The drug rituximab has been mentioned in the context of this disorder. Affiliated tissues include thymus, breast and myeloid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Mediastinal Malignant Lymphoma

Diseases related to Mediastinal Malignant Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 hodgkin's lymphoma, lymphocytic-histiocytic predominance 30.1 TNFRSF8 FUT4
2 lymphoblastic lymphoma 29.4 TNFRSF8 PAX5
3 lymphoma, hodgkin, classic 29.4 TNFRSF8 POU2AF1 PAX5 KDM4C
4 marginal zone b-cell lymphoma 29.3 TNFRSF8 PAX5 KDM4C CD79A
5 lymphoma, mucosa-associated lymphoid type 29.3 TNFRSF8 PAX5 KDM4C CD79A
6 b-cell lymphoma 29.2 TNFRSF8 PAX5 CIITA BCL11A
7 hodgkin's lymphoma, mixed cellularity 10.2 TNFRSF8 FUT4
8 pleural lipoma 10.2 TNFRSF8 FUT4
9 uterus leiomyosarcoma 10.1 TNFRSF8 FUT4
10 uterine corpus sarcoma 10.1 TNFRSF8 FUT4
11 submandibular adenitis 10.1 TNFRSF8 PAX5
12 breast lipoma 10.1 TNFRSF8 PAX5
13 tracheal lymphoma 10.1 TNFRSF8 PAX5
14 infected hydrocele 10.0 TNFRSF8 CD79A
15 bone lymphoma 10.0 TNFRSF8 CD79A
16 breast lymphoma 10.0 TNFRSF8 CD79A
17 cerebral lymphoma 10.0 TNFRSF8 CD79A
18 germ cell and embryonal cancer 10.0 KDM4C FUT4
19 gastrointestinal lymphoma 10.0 TNFRSF8 CD79A
20 pediatric lymphoma 10.0 TNFRSF8 CD79A
21 spherocytosis, type 4 10.0 POU2AF1 PAX5
22 monoclonal paraproteinemia 10.0 PAX5 CD79A
23 reticulosarcoma 10.0 TNFRSF8 PAX5
24 hematologic cancer 9.9 TNFRSF8 PAX5 KDM4C
25 esophageal cancer 9.9
26 follicular lymphoma 9.9
27 lymphoma 9.9
28 hemopericardium 9.9
29 cardiac tamponade 9.9
30 pericardial effusion 9.9
31 vasculitis 9.9
32 lymphosarcoma 9.9
33 virus-associated trichodysplasia spinulosa 9.9
34 primary mediastinal large b-cell lymphoma 9.9
35 adult acute lymphocytic leukemia 9.9 TNFRSF8 PAX5
36 testicular disease 9.9 TNFRSF8 KDM4C
37 ocular cicatricial pemphigoid 9.9 CIITA CD79A
38 autoimmune disease 9.9
39 mantle cell lymphoma 9.9
40 paraganglioma 9.9
41 spleen cancer 9.9 PAX5 CD79A
42 cll/sll 9.9 PAX5 CD79A
43 membranoproliferative glomerulonephritis 9.9 FUT4 CD79A
44 myeloid sarcoma 9.9 PAX5 CD79A
45 mature t-cell and nk-cell lymphoma 9.9 TNFRSF8 KDM4C CD79A
46 primary mediastinal b-cell lymphoma 9.8 KDM4C BCL11A
47 lymphoplasmacytic lymphoma 9.8 PAX5 KDM4C CD79A
48 lymphatic system cancer 9.8 TNFRSF8 KDM4C CD79A
49 lymphatic system disease 9.8 TNFRSF8 KDM4C CD79A
50 paranasal sinus lymphoma 9.8 TNFRSF8 PAX5 CD79A

Graphical network of the top 20 diseases related to Mediastinal Malignant Lymphoma:



Diseases related to Mediastinal Malignant Lymphoma

Symptoms & Phenotypes for Mediastinal Malignant Lymphoma

GenomeRNAi Phenotypes related to Mediastinal Malignant Lymphoma according to GeneCards Suite gene sharing:

26 (show all 27)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-1 9.85 POU2AF1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-106 9.85 CIITA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.85 CD79A CIITA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-112 9.85 TNFRSF8
5 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.85 CIITA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.85 POU2AF1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.85 POU2AF1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-139 9.85 CD79A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.85 CIITA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-150 9.85 KDM4C
11 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.85 CD79A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.85 CIITA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-18 9.85 TNFRSF8
14 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.85 KDM4C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.85 POU2AF1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-204 9.85 CD79A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-209 9.85 KDM4C
18 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.85 POU2AF1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.85 TNFRSF8
20 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.85 TNFRSF8
21 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.85 CIITA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.85 TNFRSF8
23 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.85 CD79A CIITA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.85 CD79A
25 Increased shRNA abundance (Z-score > 2) GR00366-A-72 9.85 KDM4C
26 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.85 CD79A
27 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.85 CIITA

MGI Mouse Phenotypes related to Mediastinal Malignant Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 BCL11A CD79A CIITA FUT4 GPR15 KDM4C
2 immune system MP:0005387 9.28 BCL11A CD79A CIITA FUT4 GPR15 KDM4C

Drugs & Therapeutics for Mediastinal Malignant Lymphoma

Drugs for Mediastinal Malignant Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved 174722-31-7 10201696

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Adjuvant Radiotherapy in Primary Mediastinal Lymphoma in Patients That Received R-CHOP Completed NCT01230008
2 Breathing Adapted Radiotherapy for Mediastinal Lymphoma Completed NCT00928096
3 A Prospective Observational Study With Longitudinal Cardiopulmonary Surveillance in Lymphoma Patients Undergoing Mediastinal Radiotherapy in the Era of Modern Chemoradiation Recruiting NCT03969693
4 Multicenter Registry Study on Proton Radiotherapy for Mediastinal Lymphomas Recruiting NCT04613388

Search NIH Clinical Center for Mediastinal Malignant Lymphoma

Genetic Tests for Mediastinal Malignant Lymphoma

Anatomical Context for Mediastinal Malignant Lymphoma

MalaCards organs/tissues related to Mediastinal Malignant Lymphoma:

40
Thymus, Breast, Myeloid, Lymph Node, Monocytes

Publications for Mediastinal Malignant Lymphoma

Articles related to Mediastinal Malignant Lymphoma:

(show top 50) (show all 282)
# Title Authors PMID Year
1
Superior vena cava syndrome caused by mediastinal lymphoma: A rare clinical case. 61
33659031 2021
2
Early Changes in Physical Activity and Quality of Life With Thoracic Radiation Therapy in Breast Cancer, Lung Cancer, and Lymphoma. 61
33223046 2021
3
Proton therapy for thoracic malignancies: a review of oncologic outcomes. 61
33118427 2021
4
Delayed sarcoidosis onset mimicking mediastinal lymphoma recurrence after complete remission of diffuse large B cell lymphoma: A case report. 61
33615672 2021
5
LOPH: a novel chemotherapeutic protocol for feline high-grade multicentric or mediastinal lymphoma, developed in an area endemic for feline leukemia virus. 61
32684120 2021
6
LOPH: a novel chemotherapeutic protocol for feline high-grade multicentric or mediastinal lymphoma, developed in an area endemic for feline leukemia virus. 61
32880509 2021
7
Deep inspiration breath hold versus free breathing technique in mediastinal radiotherapy for lymphoma. 61
33718767 2021
8
High Glucose Metabolism in the Right Ventricular Myocardium Due to Extrinsic Pulmonary Stenosis by Mediastinal Lymphoma. 61
32956125 2021
9
Primary CD20-positive mediastinal diffuse large B-cell lymphoma. 61
33005424 2020
10
EBV-Positive Primary Large B-Cell Lymphoma: The Role of Immunohistochemistry and XPO1 in the Diagnosis of Mediastinal Lymphomas. 61
31789821 2020
11
Effect of Deep Inspiration Breath Hold on Normal Tissue Sparing With Intensity Modulated Radiation Therapy Versus Proton Therapy for Mediastinal Lymphoma. 61
33305086 2020
12
Daily computed tomography image guidance: Dosimetric advantages outweigh low-dose radiation exposure for treatment of mediastinal lymphoma. 61
32593645 2020
13
Computed tomography (CT)-derived radiomic features differentiate prevascular mediastinum masses as thymic neoplasms versus lymphomas. 61
32306201 2020
14
A new domestic cat genome assembly based on long sequence reads empowers feline genomic medicine and identifies a novel gene for dwarfism. 61
33090996 2020
15
Ascending aorta pseudoaneurysm simulating mediastinal lymphoma in computed tomography, a possible diagnostic error: a case report. 61
32972458 2020
16
Biological optimization for mediastinal lymphoma radiotherapy - a preliminary study. 61
32216586 2020
17
Tracheal rupture caused by mediastinal lymphoma: a case report. 61
32843189 2020
18
[Different Energy Spectrum CT Findings between Anterior Mediastinal Lymphoma and Thymic Carcinoma]. 61
32895093 2020
19
Epidemiological, pathological and immunohistochemical aspects of 125 cases of feline lymphoma in Southern Brazil. 61
31461200 2020
20
Residual Site Radiotherapy After Immunochemotherapy in Primary Mediastinal B-Cell Lymphoma: A Monoinstitutional Retrospective Study. 61
32354938 2020
21
The Meaningless Meaning of Mean Heart Dose in Mediastinal Lymphoma in the Modern Radiation Therapy Era. 61
31586483 2020
22
Mediastinal lymphoma-induced superior vena cava syndrome and chylopericardium in a pregnant lady: A case report. 61
32500048 2020
23
Composite and sequential lymphoma between classical Hodgkin lymphoma and primary mediastinal lymphoma/diffuse large B-cell lymphoma, a clinico-pathological series of 25 cases. 61
32030731 2020
24
The Feasibility of Implementing Deep Inspiration Breath-Hold for Pediatric Radiation Therapy. 61
32005489 2020
25
Pre-Intubation Veno-Venous Extracorporeal Membrane Oxygenation in Patients at Risk for Respiratory Decompensation. 61
32280144 2020
26
Thymic carcinoid mimicking mediastinal lymphoma on 18F-FDG PET/CT. 61
32236838 2020
27
A positive approach: advances in proton therapy for the treatment of mediastinal lymphoma. 61
31976780 2020
28
Electrocardiogram-Gated Computed Tomography with Coronary Angiography for Cardiac Substructure Delineation and Sparing in Patients with Mediastinal Lymphomas Treated with Radiation Therapy. 61
31783172 2020
29
Reducing Heart Dose with Protons and Cardiac Substructure Sparing for Mediastinal Lymphoma Treatment. 61
33094130 2020
30
Removal of a self-expanding metallic Y stent in the management of reversible central airway obstruction due to mediastinal lymphoma. 61
33169825 2020
31
A case report evaluating combined effect of intensity-modulated radiotherapy and deep inspiratory breath-hold for mediastinal lymphoma: A dosimetric analysis. 61
31898622 2020
32
Mediastinal lymphoma in dogs is homogeneous compared to thymic epithelial neoplasia and is more likely to envelop the cranial vena cava in CT images. 61
31574584 2020
33
Secondary Malignancy Risk Following Proton vs. X-ray Treatment of Mediastinal Malignant Lymphoma: A Comparative Modeling Study of Thoracic Organ-Specific Cancer Risk. 61
32733794 2020
34
Volumetric assessment of mediastinal lymphoma masses in Hodgkin lymphoma. 61
31232136 2019
35
Comparative photon and proton dosimetry for patients with mediastinal lymphoma in the era of Monte Carlo treatment planning and variable relative biological effectiveness. 61
31888769 2019
36
Comparison of Techniques for Involved-Site Radiation Therapy in Patients With Lower Mediastinal Lymphoma. 61
31128302 2019
37
Significantly Increased Accumulation of 18F-FDG Throughout the Left Middle Cerebral Artery Territory Corresponding to Acute-Phase Infarction. 61
31592826 2019
38
Histological findings in patients with suspected mediastinal lymphoma relapse according to positive positron emission tomography scan during follow-up: a large retrospective analysis in 96 patients. 61
30821538 2019
39
Advantage of proton-radiotherapy for pediatric patients and adolescents with Hodgkin's disease. 61
31477141 2019
40
Lifesaving Stenting of Pulmonary Arteries Critically Narrowed by Mediastinal Lymphoma. 61
30807202 2019
41
Consolidative mediastinal irradiation of malignant lymphoma using active scanning proton beams: clinical outcome and dosimetric comparison. 61
30972453 2019
42
Cytology Versus Histology in the Primary Diagnosis of Lymphoma Located in the Mediastinum. 61
30904404 2019
43
Intrafractional Displacement of Cardiac Substructures Among Patients With Mediastinal Lymphoma or Lung Cancer. 61
31360806 2019
44
A Multicenter Study on the Utility of EBUS-TBNA and EUS-B-FNA in the Diagnosis of Mediastinal Lymphoma. 61
31238329 2019
45
Mediastinal Lymphoma Presenting in Cardiogenic Shock with Superior Vena Cava Syndrome in a Primigravida at Full Term: Salvage Resection after Prolonged Extracorporeal Life Support. 61
31244642 2019
46
Value of CT spectral imaging in the differential diagnosis of thymoma and mediastinal lymphoma. 61
30507309 2019
47
Early Changes in Cardiovascular Biomarkers with Contemporary Thoracic Radiation Therapy for Breast Cancer, Lung Cancer, and Lymphoma. 61
30445173 2019
48
Comparison of butterfly volumetric modulated arc therapy to full arc with or without deep inspiration breath hold for the treatment of mediastinal lymphoma. 61
30245037 2018
49
Checkpoint Inhibitors Hodgkin Lymphoma and Non-Hodgkin Lymphoma. 61
30338457 2018
50
Utility of minimally invasive thoracoscopy for assessment of residual mediastinal lymphoma. 61
30077390 2018

Variations for Mediastinal Malignant Lymphoma

Expression for Mediastinal Malignant Lymphoma

Search GEO for disease gene expression data for Mediastinal Malignant Lymphoma.

Pathways for Mediastinal Malignant Lymphoma

Pathways related to Mediastinal Malignant Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 TNFRSF8 PAX5 CIITA CD79A
2 10.54 CIITA CD79A

GO Terms for Mediastinal Malignant Lymphoma

Biological processes related to Mediastinal Malignant Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 humoral immune response GO:0006959 8.62 POU2AF1 PAX5

Sources for Mediastinal Malignant Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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