MCID: MDS019
MIFTS: 35

Mediastinal Malignant Lymphoma

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Mediastinal Malignant Lymphoma

MalaCards integrated aliases for Mediastinal Malignant Lymphoma:

Name: Mediastinal Malignant Lymphoma 12 15
Lymphoma of Mediastinum 12
Mediastinal Lymphoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:6868
NCIt 50 C6633
UMLS 73 C1334665

Summaries for Mediastinal Malignant Lymphoma

MalaCards based summary : Mediastinal Malignant Lymphoma, also known as lymphoma of mediastinum, is related to lymphoma and nodular lymphocyte predominant hodgkin lymphoma. An important gene associated with Mediastinal Malignant Lymphoma is EPHA7 (EPH Receptor A7), and among its related pathways/superpathways are NF-kappaB Signaling and Interleukin-4 and 13 signaling. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include b cells and nk cells, and related phenotypes are cellular and hematopoietic system

Related Diseases for Mediastinal Malignant Lymphoma

Diseases related to Mediastinal Malignant Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 lymphoma 29.6 BCL11A BCL6 PAX5 REL TNFRSF8
2 nodular lymphocyte predominant hodgkin lymphoma 10.6 BCL6 PAX5
3 primary mediastinal b-cell lymphoma 10.6 BCL6 REL
4 composite lymphoma 10.5 BCL6 PAX5
5 chromosome 2p16.1-p15 deletion syndrome 10.5 BCL11A REL XPO1
6 primary mediastinal large b-cell lymphoma 10.4 BCL6 CD274 XPO1
7 malignant leydig cell tumor 10.4 PAX5 TNFRSF8
8 intraocular lymphoma 10.4 BCL6 PAX5
9 mediastinal gray zone lymphoma 10.4 CD274 EPHA7 HOXA5 PAX5
10 sternum cancer 10.3 FUT4 TNFRSF8
11 gray zone lymphoma 10.3 BCL11A CD274 EPHA7 PAX5
12 t-cell/histiocyte rich large b cell lymphoma 10.3 BCL6 TNFRSF8
13 myasthenic syndrome, congenital, 14 10.3 CD274 PDCD1LG2
14 primary central nervous system lymphoma 10.3 BCL6 PAX5
15 colon lymphoma 10.2 BCL6 TNFRSF8
16 mediastinitis 10.2
17 lymphosarcoma 10.2
18 lung lymphoma 10.2 BCL6 PAX5 TNFRSF8
19 reticulosarcoma 10.2 BCL6 PAX5 TNFRSF8
20 testicular infarct 10.1 FUT4 TNFRSF8
21 epidural neoplasm 10.0 BCL6 FUT4 TNFRSF8
22 diffuse large b-cell lymphoma 10.0 BCL6 REL TNFRSF8
23 multicentric castleman disease 9.9 BCL6 PAX5
24 b-cell lymphomas 9.8 BCL6 PAX5 REL TNFRSF8
25 reticulohistiocytic granuloma 9.4 FSCN1 FUT4 TNFRSF8
26 hematologic cancer 9.4 BCL6 IL3RA PAX5 TNFRSF8
27 colloid carcinoma of the pancreas 9.3 FSCN1 FSCN3
28 hodgkin's lymphoma, lymphocytic depletion 8.6 FSCN1 FSCN3 FUT4 PAX5 TNFRSF8

Graphical network of the top 20 diseases related to Mediastinal Malignant Lymphoma:



Diseases related to Mediastinal Malignant Lymphoma

Symptoms & Phenotypes for Mediastinal Malignant Lymphoma

MGI Mouse Phenotypes related to Mediastinal Malignant Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.85 BCL11A BCL6 CD274 DAPK1 FSCN1 FUT4
2 hematopoietic system MP:0005397 9.77 ANO6 BCL11A BCL6 CD274 FUT4 GPR15
3 immune system MP:0005387 9.44 HMOX1 HOXA5 IL3RA PAX5 PDCD1LG2 REL

Drugs & Therapeutics for Mediastinal Malignant Lymphoma

Drugs for Mediastinal Malignant Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 2,Phase 1
2 Immunoglobulins Phase 2,Phase 1
3 Antibodies, Monoclonal Phase 2,Phase 1
4
rituximab Approved Phase 1,Not Applicable 174722-31-7 10201696
5
Fludarabine Approved Phase 1 21679-14-1, 75607-67-9 30751
6
Lenalidomide Approved Phase 1 191732-72-6 216326
7
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
8
Pembrolizumab Approved Phase 1 1374853-91-4
9
Blinatumomab Approved, Investigational Phase 1 853426-35-4
10
Omeprazole Approved, Investigational, Vet_approved Phase 1 73590-58-6 4594
11
Fluconazole Approved, Investigational Phase 1 86386-73-4 3365
12
Miconazole Approved, Investigational, Vet_approved Phase 1 22916-47-8 4189
13
Repaglinide Approved, Investigational Phase 1 135062-02-1 65981
14
Nicotinamide Approved, Investigational, Nutraceutical Phase 1 98-92-0 936
15
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
16
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
17 Muromonab-CD3 Phase 1
18 Interleukin-2 Phase 1
19 Alkylating Agents Phase 1
20 Micronutrients Phase 1
21 Nicotinic Acids Phase 1
22 Trace Elements Phase 1
23 Angiogenesis Inhibitors Phase 1
24 Angiogenesis Modulating Agents Phase 1
25 Vasodilator Agents Phase 1
26 Anti-Bacterial Agents Phase 1
27 Vitamin B Complex Phase 1
28 Hypolipidemic Agents Phase 1
29 Pharmaceutical Solutions Phase 1
30 Vitamins Phase 1
31 Antibodies, Bispecific Phase 1
32 Immunosuppressive Agents Phase 1
33 Anti-Infective Agents Phase 1
34 Lipid Regulating Agents Phase 1
35 Antirheumatic Agents Phase 1,Not Applicable
36 Antimetabolites Phase 1
37 Antineoplastic Agents, Alkylating Phase 1
38 Gastrointestinal Agents Phase 1
39 Steroid Synthesis Inhibitors Phase 1
40 Cytochrome P-450 CYP2C9 Inhibitors Phase 1
41 Cytochrome P-450 CYP3A Inhibitors Phase 1
42 Cytochrome P-450 Enzyme Inhibitors Phase 1
43 Hormone Antagonists Phase 1
44 Hormones Phase 1
45 Antacids Phase 1
46 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
47 Hypoglycemic Agents Phase 1
48 Antifungal Agents Phase 1
49 Proton Pump Inhibitors Phase 1
50 Anti-Ulcer Agents Phase 1

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 A Study of SGN-35 (Brentuximab Vedotin) of Patients With Relapsed or Refractory PMLBCL Completed NCT02423291 Phase 2 Brentuximab Vedotin
2 Radiotherapy Delivery in Deep Inspiration for Pediatric Patients Recruiting NCT03315546 Phase 1, Phase 2
3 Lenalidomide and Blinatumomab in Treating Patients With Relapsed Non-Hodgkin Lymphoma Recruiting NCT02568553 Phase 1 Lenalidomide
4 Open-Label, Multi-Center, Two-Part, Ph1 Study to Characterize the PKs of an Intravenous Micro-Dose of [14C]-Tazemetostat (EPZ 6438) and the ADME of an Oral [14C]-Labeled Dose of Tazemetostat in Subjects With B-Cell Lymphomas or Adv Solid Tumors Recruiting NCT03010982 Phase 1 Tazemetostat and [14C] Tazemetostat
5 Pembrolizumab and Ibrutinib in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma Recruiting NCT02950220 Phase 1 Ibrutinib
6 Ph I Trial of NAM NK Cells and IL-2 for Adult Pts With MM and NHL Recruiting NCT03019666 Phase 1
7 Open-Label, Multicenter, Two-Part, Phase 1 Study to Characterize Effects of a Moderate CYP3A Inhibitor on PK of Tazemetostat, Effects of Tazemetostat on PK of CYP2C8 and CYP2C19 Substrates, and Effect of Increased Gastric pH on PK of Tazemetostat in B-cel Active, not recruiting NCT03028103 Phase 1 Tazemetostat;Fluconazole;Omeprazole;Repaglinide
8 Radiotherapy in Primary Mediastinal Lymphoma Completed NCT01230008
9 Breathing Adapted Radiotherapy for Mediastinal Lymphoma Completed NCT00928096
10 A Clinico-Pathologic Study of Primary Mediastinal B-Cell Lymphoma Completed NCT00944567
11 Cardiotoxicity of Radiation Therapy (CTRT) Recruiting NCT02769299
12 Randomized, Open-label, Two-arms, Phase III Comparative Study Assessing the Role of Involved Mediastinal Radiotherapy After Rituximab Containing Chemotherapy Regimens to Patients With Newly Diagnosed Primary Mediastinal Large B-Cell Lymphoma Recruiting NCT01599559 Not Applicable

Search NIH Clinical Center for Mediastinal Malignant Lymphoma

Genetic Tests for Mediastinal Malignant Lymphoma

Anatomical Context for Mediastinal Malignant Lymphoma

MalaCards organs/tissues related to Mediastinal Malignant Lymphoma:

41
B Cells, Nk Cells

Publications for Mediastinal Malignant Lymphoma

Articles related to Mediastinal Malignant Lymphoma:

# Title Authors Year
1
Takayasu's arteritis misdiagnosed as mediastinal malignant lymphoma: a case report and review of the literature. ( 24977018 )
2014
2
Posterior mediastinal malignant lymphoma mimicking a neurogenic tumor. ( 23336918 )
2013
3
Mediastinal malignant lymphoma difficult to diagnose: a patient report. ( 24031133 )
2011
4
Magnetic resonance imaging and 67Ga scan versus computed tomography in the staging and in the monitoring of mediastinal malignant lymphoma: a prospective pilot study. ( 9220410 )
1996
5
Magnetic resonance imaging and 67gallium scan in mediastinal malignant lymphoma: a prospective pilot study. ( 8075050 )
1994
6
Primary mediastinal malignant lymphoma. ( 1550890 )
1992
7
Mediastinal malignant lymphoma complicated with esophagobronchial fistula: successfully treated case. ( 3694829 )
1987
8
Mediastinal malignant lymphoma. ( 5537415 )
1970
9
An unusual case of paroxysmal auricular fibrillation due to mediastinal malignant lymphoma. ( 14818942 )
1951

Variations for Mediastinal Malignant Lymphoma

Expression for Mediastinal Malignant Lymphoma

Search GEO for disease gene expression data for Mediastinal Malignant Lymphoma.

Pathways for Mediastinal Malignant Lymphoma

Pathways related to Mediastinal Malignant Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.68 BCL6 CD274 HMOX1 PAX5 PDCD1LG2 REL
2 11.51 BCL6 FSCN1 HMOX1 MAOA
3 11.2 CD274 PDCD1LG2 TNFRSF8
4 10.98 BCL6 IL3RA PAX5 TNFRSF8

GO Terms for Mediastinal Malignant Lymphoma

Cellular components related to Mediastinal Malignant Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection membrane GO:0031253 8.62 FSCN1 FSCN3

Biological processes related to Mediastinal Malignant Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.55 BCL6 FSCN1 HMOX1 IL3RA MAOA
2 negative regulation of interferon-gamma production GO:0032689 9.37 CD274 PDCD1LG2
3 negative regulation of interleukin-10 production GO:0032693 9.32 CD274 PDCD1LG2
4 negative regulation of activated T cell proliferation GO:0046007 9.26 CD274 PDCD1LG2
5 positive regulation of apoptotic process GO:0043065 9.1 ANO6 BCL6 EPHA7 HMOX1 HOXA5 TNFRSF8
6 negative regulation of mast cell cytokine production GO:0032764 8.96 BCL6 HMOX1

Sources for Mediastinal Malignant Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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