Mediastinal Mesenchymal Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Mediastinal Mesenchymal Tumor

MalaCards integrated aliases for Mediastinal Mesenchymal Tumor:

Name: Mediastinal Mesenchymal Tumor ¹² ¹⁵

Soft Tissue Tumour of Mediastinum ¹²

Soft Tissue Tumor of Mediastinum ¹²

Mediastinal Mesenchymal Tumour ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5560

NCIt ⁵⁰ C6637

UMLS ⁷¹ C1334669

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Summaries for Mediastinal Mesenchymal Tumor

MalaCards based summary : Mediastinal Mesenchymal Tumor, also known as soft tissue tumour of mediastinum, is related to proliferative fasciitis and pseudosarcomatous fibromatosis. An important gene associated with Mediastinal Mesenchymal Tumor is SSX4B (SSX Family Member 4B). Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Mediastinal Mesenchymal Tumor

Diseases related to Mediastinal Mesenchymal Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)

#	Related Disease	Score	Top Affiliating Genes
1	proliferative fasciitis	9.9	NAB2 CAMTA1
2	pseudosarcomatous fibromatosis	9.8	SS18 NAB2
3	sarcoma	9.8	SSX4B SSX4 SS18
4	bone angioendothelial sarcoma	9.8	SSX4B SSX4 SS18
5	spindle cell synovial sarcoma	9.7	TLE1 SS18
6	kidney sarcoma	9.7	TLE1 SS18
7	epithelioid malignant peripheral nerve sheath tumor	9.7	TLE1 SS18
8	monophasic synovial sarcoma	9.7	TLE1 SS18
9	spindle cell sarcoma	9.6	TLE1 SS18
10	chondrosarcoma, extraskeletal myxoid	9.6	TLE1 SS18
11	dedifferentiated liposarcoma	9.6	SS18 NAB2
12	hemangiopericytoma, malignant	9.4	TLE1 SS18 NAB2
13	myxofibrosarcoma	9.4	TLE1 SS18 NAB2
14	synovium neoplasm	9.3	TLE1 SSX4B SSX4 SS18
15	biphasic synovial sarcoma	9.3	TLE1 SSX4B SSX4 SS18
16	synovium cancer	9.3	TLE1 SSX4B SSX4 SS18
17	sarcoma, synovial	9.3	TLE1 SSX4B SSX4 SS18

Graphical network of the top 20 diseases related to Mediastinal Mesenchymal Tumor:

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Symptoms & Phenotypes for Mediastinal Mesenchymal Tumor

GenomeRNAi Phenotypes related to Mediastinal Mesenchymal Tumor according to GeneCards Suite gene sharing:

²⁶ (show all 12)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-117	9.88	SSX4 SSX4B
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-134	9.88	SSX4 SSX4B
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-149	9.88	SSX4 SSX4B
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	9.88	SSX4 SSX4B
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-49	9.88	SSX4 SSX4B
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-51	9.88	SSX4 SSX4B
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-53	9.88	SSX4 SSX4B
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-67	9.88	SSX4 SSX4B
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-82	9.88	SSX4 SSX4B
10	Decreased shRNA abundance (Z-score < -2)	GR00366-A-110	9.13	TLE1
11	Decreased shRNA abundance (Z-score < -2)	GR00366-A-111	9.13	TLE1
12	Decreased shRNA abundance (Z-score < -2)	GR00366-A-183	9.13	TLE1

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Drugs & Therapeutics for Mediastinal Mesenchymal Tumor

Search Clinical Trials , NIH Clinical Center for Mediastinal Mesenchymal Tumor

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Genetic Tests for Mediastinal Mesenchymal Tumor

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Anatomical Context for Mediastinal Mesenchymal Tumor

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Publications for Mediastinal Mesenchymal Tumor

Articles related to Mediastinal Mesenchymal Tumor:

#	Title	Authors	PMID	Year
1	CT features of mediastinal lymphangiohemangioma associated with superior vena cava ectasia. A case report. ⁶¹	Wong AM...Lee KF	11016760	2000
2	Benign mesenchymoma of the mediastinum: a case report. ⁶¹	Hsieh SP...Tseng HH	8940795	1996

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Genes for Mediastinal Mesenchymal Tumor

Genes related to Mediastinal Mesenchymal Tumor (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SSX4B	SSX Family Member 4B	Protein Coding	5.1	DISEASES inferred ¹⁵
2	SSX4	SSX Family Member 4	Protein Coding	5.09	DISEASES inferred ¹⁵
3	CAMTA1	Calmodulin Binding Transcription Activator 1	Protein Coding	4.9	DISEASES inferred ¹⁵
4	NAB2	NGFI-A Binding Protein 2	Protein Coding	4.87	DISEASES inferred ¹⁵
5	TLE1	TLE Family Member 1, Transcriptional Corepressor	Protein Coding	4.68	DISEASES inferred ¹⁵
6	SS18	SS18 Subunit Of BAF Chromatin Remodeling Complex	Protein Coding	4.66	DISEASES inferred ¹⁵

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Variations for Mediastinal Mesenchymal Tumor

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Expression for Mediastinal Mesenchymal Tumor

Search GEO for disease gene expression data for Mediastinal Mesenchymal Tumor.

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Pathways for Mediastinal Mesenchymal Tumor

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GO Terms for Mediastinal Mesenchymal Tumor

Cellular components related to Mediastinal Mesenchymal Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:0005634	9.1	TLE1 SSX4B SSX4 SS18 NAB2 CAMTA1

Biological processes related to Mediastinal Mesenchymal Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of transcription, DNA-templated	GO:0006355	8.92	TLE1 SSX4B SSX4 NAB2

Molecular functions related to Mediastinal Mesenchymal Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transcription corepressor activity	GO:0003714	8.96	TLE1 NAB2
2	transcription coregulator activity	GO:0003712	8.62	NAB2 CAMTA1

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