MCID: MDS022
MIFTS: 46

Mediastinitis

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Aliases & Classifications for Mediastinitis

MalaCards integrated aliases for Mediastinitis:

Name: Mediastinitis 11 43 14 71 75

External Ids:

Disease Ontology 11 DOID:819
ICD9CM 34 519.2
MeSH 43 D008480
NCIt 49 C26827
SNOMED-CT 68 47597000
UMLS 71 C0025064

Summaries for Mediastinitis

Disease Ontology: 11 A connective tissue disease characterized by inflammation located in the mediastinum, which extends from the diaphragm to the thoracic inlet and between the pleural cavities.

MalaCards based summary: Mediastinitis is related to bacteremia 2 and toxic shock syndrome, and has symptoms including chest pain and signs and symptoms. An important gene associated with Mediastinitis is MPO (Myeloperoxidase), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include mediastinum, heart and kidney, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia: 75 Mediastinitis is inflammation of the tissues in the mid-chest, or mediastinum. It can be either acute or... more...

Related Diseases for Mediastinitis

Diseases related to Mediastinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1071)
# Related Disease Score Top Affiliating Genes
1 bacteremia 2 30.8 LACTB CRP
2 toxic shock syndrome 30.7 IL6 F3 CRP
3 tonsillitis 30.5 MPO LACTB IL6
4 pericarditis 30.5 IL6 CRP ACE
5 epiglottitis 30.4 LACTB CRP
6 igg4-related disease 30.4 MPO CRP CD4
7 adult respiratory distress syndrome 30.3 MPO IL6 F5 CRP
8 pleural empyema 30.2 IL6 F2 CRP CD4 ALB
9 heart septal defect 30.2 F3 F2 CRP
10 lemierre's syndrome 30.2 F3 F2 CRP
11 thyroiditis 30.1 INS IL6 CRP
12 pharyngitis 30.0 LACTB IL6 CRP CD4
13 goiter 30.0 INS IL6 CRP
14 pericardial tuberculosis 30.0 CRP CD4
15 endocarditis 29.9 LACTB IL6 F2 CRP ALB
16 pyomyositis 29.9 CRP CD4
17 nocardiosis 29.9 CRP CD4
18 parotitis 29.9 CRP CD4 ALB
19 brucellosis 29.9 MPO IL6 CRP
20 pelvic inflammatory disease 29.9 MPO LACTB CRP
21 horner's syndrome 29.9 F3 CRP
22 cervical adenitis 29.9 CRP CD4
23 gas gangrene 29.8 IL6 CRP ALB
24 pulmonary edema 29.8 F2 CRP ACE
25 peritonitis 29.8 MPO IL6 F2 CRP ALB
26 actinomycosis 29.8 CRP CD4 ALB
27 thrombophilia due to thrombin defect 29.8 F5 F3 F2
28 necrotizing fasciitis 29.8 INS IL6 F3 F2 CRP ALB
29 varicose veins 29.8 IL6 F5 F2
30 acute pancreatitis 29.8 MPO INS IL6 CRP
31 constrictive pericarditis 29.7 CRP ALB ACE
32 graves disease 1 29.7 INS CRP ALB
33 mucormycosis 29.7 INS IL6 CRP CD4
34 acute necrotizing pancreatitis 29.7 MPO IL6 CRP
35 pancreatitis 29.7 INS IL6 CRP ALB
36 aortic dissection 29.7 IL6 CRP ALB ACE
37 carotid stenosis 29.6 MPO CRP ACE
38 gastroesophageal reflux 29.6 MPO IL6 ATP4A ATP12A
39 blastomycosis 29.6 IL6 CRP CD4
40 multiple endocrine neoplasia, type i 29.6 INS ATP4A ATP12A
41 septic arthritis 29.6 IL6 CRP CD4 ALB
42 invasive aspergillosis 29.6 IL6 CRP CD4
43 bronchitis 29.6 MPO LACTB IL6 CRP ALB
44 disseminated intravascular coagulation 29.6 IL6 F5 F3 F2 CRP
45 adult syndrome 29.6 INS IL6 CRP
46 esophageal tuberculosis 29.6 CRP ATP4A ATP12A ALB
47 periodontitis 29.6 MPO IL6 CRP
48 lymph node tuberculosis 29.5 CRP CD4 ALB
49 leptin deficiency or dysfunction 29.5 INS IL6 CRP CD4
50 acne 29.5 INS IL6 CRP

Comorbidity relations with Mediastinitis via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease
Intermediate Coronary Syndrome Respiratory Failure

Graphical network of the top 20 diseases related to Mediastinitis:



Diseases related to Mediastinitis

Symptoms & Phenotypes for Mediastinitis

UMLS symptoms related to Mediastinitis:


chest pain; signs and symptoms

MGI Mouse Phenotypes related to Mediastinitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 ACE ALB ATP12A ATP4A CD4 CRP
2 growth/size/body region MP:0005378 10.11 ACE ATP12A ATP4A CD4 F2 F3
3 muscle MP:0005369 9.98 ALB F2 F3 IL6 INS MPO
4 neoplasm MP:0002006 9.93 ACE ALB ATP4A F3 IL6 TCF21
5 endocrine/exocrine gland MP:0005379 9.92 ACE ALB ATP4A CD4 F2 IL6
6 cardiovascular system MP:0005385 9.9 ACE ALB CRP F2 F3 F5
7 digestive/alimentary MP:0005381 9.86 ALB ATP12A ATP4A CD4 F2 IL6
8 immune system MP:0005387 9.7 ACE ALB ATP4A CD4 CRP F2
9 mortality/aging MP:0010768 9.36 ACE ALB ATP4A CD4 F2 F3

Drugs & Therapeutics for Mediastinitis

Drugs for Mediastinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2, Phase 3
2 Immunologic Factors Phase 2, Phase 3
3
Vancomycin Approved 1404-90-6 14969
4
Meticillin Approved, Investigational 61-32-5 6087
5
Daptomycin Approved, Investigational 103060-53-3 16129629
6
Nitric Oxide Approved 10102-43-9 145068
7
Creatine Approved, Investigational, Nutraceutical 57-00-1 586
8 Anti-Infective Agents
9 Anti-Bacterial Agents
10 Antibiotics, Antitubercular

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 A Randomized, Controlled, Phase 4 Study of Sternal Plating (Rapid Sternal Closure System, KLS Martin L.P.) in Cardiac Surgical Subjects at Higher Risk for Sternal Wound Complications. Completed NCT00638014 Phase 4
2 A Randomized, Multicenter, Double-Blind, Group-Sequential Study to Evaluate the Efficacy, Immunogenicity, and Safety of a Single Dose of Merck 0657nI Staphylococcus Aureus Vaccine (V710) in Adult Patients Scheduled for Cardiothoracic Surgery Terminated NCT00518687 Phase 2, Phase 3
3 Immunological and Bacteriological Approaches to the Development of Postoperative Mediastinitis With Staphylococcus Aureus Unknown status NCT03262558
4 Endoscopic - Vacuum Assisted Closure of Intrathoracic Postsurgical Leaks Unknown status NCT00876551
5 Delayed Primary Versus Late Secondary Wound Closure in the Treatment of Postsurgical Sternum Osteomyelitis Unknown status NCT01473979
6 Topical Vancomycin in Prevention of Methicillin-Resistant Staphylococcal Related Mediastinitis in Patients Receiving Coronary Artery Bypass Graft Completed NCT00711685
7 Post-Surgical Mediastinitis: Retrospective Study of Cases Treated Within the CHU Brugmann Hospital Completed NCT03922191
8 Prognostic Factors for Descending Necrotizing Mediastinitis Development in Deep Space Neck Infections - A Retrospective Study Completed NCT04865003
9 A Randomized, Controlled Study of Physiotherapy Exercises in Patients With Sternal Instability Due to Mediastinitis After Cardiovascular Surgery Completed NCT02513576
10 A Prospective, Randomized-Controlled, Multicenter Study Evaluating Primary Plating in High-Risk Median Sternotomy Patients for Osteosynthesis and Pain Completed NCT00819286
11 Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2 Completed NCT02073760
12 Acute Kidney Injury During Daptomycin Versus Vancomycin Treatment in Cardiovascular Critically Ill Patients: a Propensity Score Matched Analysis Completed NCT03961503 Daptomycin (DAP) treatment;Vancomycin (VAN) treatment
13 Infectious Mediastinitis Among the Strasbourg Universitary Hospital, a Retrospective Cohort Recruiting NCT05001308
14 Experience With the Combined Method of Air-plasma Flow and Nitric Oxide Therapy in the Prevention and Treatment of Wound Infectious Complications in Cardiac Surgery Recruiting NCT04617353

Search NIH Clinical Center for Mediastinitis

Cochrane evidence based reviews: mediastinitis

Genetic Tests for Mediastinitis

Anatomical Context for Mediastinitis

Organs/tissues related to Mediastinitis:

FMA: Mediastinum
MalaCards : Heart, Kidney, Lung, Lymph Node, Bone, Trachea, Skin

Publications for Mediastinitis

Articles related to Mediastinitis:

(show top 50) (show all 4283)
# Title Authors PMID Year
1
Periprosthetic joint infection due to Mycoplasma hominis in a multiple sclerosis patient treated with fingolimod. 62
36064142 2022
2
A new clinical classification and reconstructive strategy for post-sternotomy surgical site infection. 62
36382133 2022
3
Scedosporium apiospermum mediastinitis in an orthotopic heart transplant recipient. 62
36277499 2022
4
Co-Management Reduces Mortality in Post-Sternotomy Mediastinitis. 62
36346276 2022
5
A Novel Case Report of Iatrogenic Tracheal Rupture Caused by a Laser-Resistant Endotracheal Tube Under Transoral Laser Laryngeal and Nasopharyngeal Surgery. 62
36471649 2022
6
Routine Donor and Recipient Screening for Mycoplasma hominis and Ureaplasma Species in Lung Transplant Recipients. 62
36467297 2022
7
Management of pediatric sternal wounds following congenital heart surgery: The role of the plastic surgeon in debridement and closure. 62
35979680 2022
8
Predictors of prolonged hospitalization in modified sternoplasty following postoperative mediastinitis. 62
36378944 2022
9
Mortality after sternal reconstruction with pectoralis major flap vs omental flap for postsurgical mediastinitis: A systematic review and meta-analysis. 62
36378934 2022
10
Traumatic chest wall pyomyositis presenting with mediastinitis. 62
36389440 2022
11
Idiopathic focal fibrosing mediastinitis with unilateral pulmonary arterial and venous involvement. 62
36378938 2022
12
An Unusual Clinical Outcome and Surgical Intervention for Mediastinal Histoplasmosis. 62
36465220 2022
13
A novel model for predicting mortality in the management of deep neck infections. 62
36318220 2022
14
Evaluation of clinical parameters affecting the prognosis in surgically treated patients with descending necrotizing mediastinitis - A retrospective study. 62
35580784 2022
15
Fibrosing mediastinitis in a child with Mendelian susceptibility to mycobacterial disease possibly due to Bacillus Calmette-Guérin. 62
36397171 2022
16
Esophagomediastinal fistula: a rare case of gastrointestinal tuberculosis. 62
35485249 2022
17
Incidence and Risk Factors for Infectious Complications of EBUS-TBNA: Prospective Multicenter Study. 62
36446657 2022
18
Mucosal Injury During Per-oral Endoscopic Myotomy: A Single-Center Experience. 62
36098360 2022
19
Cervico-thoracic cellulitis at the Yalgado Ouedraogo University Hospital: About 50 cases. 62
35853556 2022
20
Skin Manifestations in Patients with Selective Immunoglobulin E Deficiency. 62
36431272 2022
21
Incidence and challenges in management of hemodialysis catheter-related infections. 62
36446808 2022
22
Effect of waiting time for COVID-19 screening on postoperative outcomes of type A aortic dissection: An institutional study. 62
35971227 2022
23
A Potential Complication After Drainage in Odontogenic Descending Necrotizing Mediastinitis: Chyle Leakage. 62
35067529 2022
24
Risk Factors Associated with Post-Operative Complications in Multidisciplinary Treatment of Descending Necrotizing Mediastinitis. 62
36362592 2022
25
Video-assisted thoracoscopic mediastinotomy for the treatment of mediastinitis in a patient with azygos lobe. 62
35568613 2022
26
A First Suspected Case of Fibrosing Mediastinitis After Anti-PD-1 Therapy. 62
36299648 2022
27
A rare case: Descending necrotizing mediastinitis. 62
36353386 2022
28
Omental Flap for Complex Sternal Wounds and Mediastinal Infection Following Cardiac Surgery. 62
36257544 2022
29
Non-infectious sternal dehiscence after coronary artery bypass surgery. 62
36192764 2022
30
[Idiopathic and Iatrogenic Esophageal Rupture]. 62
36155588 2022
31
Relationship between mysticism and severe odontogenic infections in Africa: what to do? 62
35431178 2022
32
Observation of Retropharyngeal Fluid Collection in 2 COVID-19 Positive Patients. 62
33155845 2022
33
Mediastinitis after a cryopreserved allograft tracheal transplant treated by transposition of the major omentum. 62
36005860 2022
34
Video-assisted thoracoscopic surgery for a pediatric patient with descending necrotizing mediastinitis. 62
36247887 2022
35
Survival rate of odontogenic descending necrotizing mediastinitis. Our experience in last 5 years. 62
36173718 2022
36
Enhanced strategy against mediastinitis with thoracic vascular graft infection: A combination of hydro-debridement with pulsed lavage and negative pressure wound therapies. 62
35771228 2022
37
Descending mediastinitis mimicking a pharyngo-laryngeal neoplasia. 62
36162746 2022
38
Impact of a Surgical Wound Infection Prevention Bundle in Pediatric Cardiothoracic Surgery. 62
36126719 2022
39
Role of early extraction of odontogenic focus in deep neck infections. 62
36173714 2022
40
Delayed Diagnosis of Pediatric Sternoclavicular Joint Infections and Clavicular Osteomyelitis During the COVID-19 Pandemic: A Report of 3 Cases. 62
36166203 2022
41
Ludwig's angina: An alarming radiology challenge. 62
35784784 2022
42
Management of failing bidirectional cavopulmonary shunt: Influence of additional systemic-to-pulmonary-artery shunt with classic Glenn physiology. 62
36172411 2022
43
The rare case of oesophago-pericardial fistula secondary to pulmonary tuberculosis. 62
36168442 2022
44
[Acute Mediastinitis]. 62
36155583 2022
45
Acute Suppurative Thyroiditis (AST) With Thyroid Abscess: A Rare and Potentially Fatal Neck Infection. 62
36249640 2022
46
Esophageal Perforation Accompanying Mediastinitis in Blunt Trauma in a Patient with Thoracic Osteophytes. 62
35135923 2022
47
[Coronary Artery Bypass Grafting via Partial Sternotomy Late after Partial Chest Wall Resection:Report of a Case]. 62
35892306 2022
48
Management of descending necrotizing mediastinitis with severe thoracic empyema using minimally invasive video-assisted thoracoscopic surgery: a case report. 62
36072533 2022
49
A Community-Based Pancreatic Cancer Screening Study in High-Risk Individuals: Preliminary Efficacy and Safety Results. 62
35854467 2022
50
[Initial and Long-term Results of Omental Flap Coverage for the Complications after Thoracic Aortic Aneurysm Repair]. 62
35892295 2022

Variations for Mediastinitis

Expression for Mediastinitis

Search GEO for disease gene expression data for Mediastinitis.

Pathways for Mediastinitis

GO Terms for Mediastinitis

Cellular components related to Mediastinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.96 MPO INS IL6 F5 F3 F2
2 endoplasmic reticulum lumen GO:0005788 9.4 INS IL6 F5 F2 CD4 ALB

Biological processes related to Mediastinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil mediated immunity GO:0002446 9.56 IL6 ACE
2 acute-phase response GO:0006953 9.23 INS IL6 F2 CRP
3 regulation of body fluid levels GO:0050878 9.16 F5 F2
4 hemostasis GO:0007599 9.13 F5 F3 F2

Molecular functions related to Mediastinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 P-type sodium:potassium-exchanging transporter activity GO:0005391 9.46 ATP4A ATP12A
2 P-type potassium transmembrane transporter activity GO:0008556 8.96 ATP4A ATP12A
3 P-type potassium:proton transporter activity GO:0008900 8.92 ATP4A ATP12A

Sources for Mediastinitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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