Mediastinitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Mediastinitis

MalaCards integrated aliases for Mediastinitis:

Name: Mediastinitis ¹¹ ⁴³ ¹⁴ ⁷¹ ⁷⁵

External Ids:

Disease Ontology ¹¹ DOID:819

ICD9CM ³⁴ 519.2

MeSH ⁴³ D008480

NCIt ⁴⁹ C26827

SNOMED-CT ⁶⁸ 47597000

UMLS ⁷¹ C0025064

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Summaries for Mediastinitis

Disease Ontology: ¹¹ A connective tissue disease characterized by inflammation located in the mediastinum, which extends from the diaphragm to the thoracic inlet and between the pleural cavities.

MalaCards based summary: Mediastinitis is related to bacteremia 2 and toxic shock syndrome, and has symptoms including chest pain and signs and symptoms. An important gene associated with Mediastinitis is MPO (Myeloperoxidase), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include mediastinum, heart and kidney, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia: ⁷⁵ Mediastinitis is inflammation of the tissues in the mid-chest, or mediastinum. It can be either acute or... more...

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Related Diseases for Mediastinitis

Diseases related to Mediastinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1071)

#	Related Disease	Score	Top Affiliating Genes
1	bacteremia 2	30.8	LACTB CRP
2	toxic shock syndrome	30.7	IL6 F3 CRP
3	tonsillitis	30.5	MPO LACTB IL6
4	pericarditis	30.5	IL6 CRP ACE
5	epiglottitis	30.4	LACTB CRP
6	igg4-related disease	30.4	MPO CRP CD4
7	adult respiratory distress syndrome	30.3	MPO IL6 F5 CRP
8	pleural empyema	30.2	IL6 F2 CRP CD4 ALB
9	heart septal defect	30.2	F3 F2 CRP
10	lemierre's syndrome	30.2	F3 F2 CRP
11	thyroiditis	30.1	INS IL6 CRP
12	pharyngitis	30.0	LACTB IL6 CRP CD4
13	goiter	30.0	INS IL6 CRP
14	pericardial tuberculosis	30.0	CRP CD4
15	endocarditis	29.9	LACTB IL6 F2 CRP ALB
16	pyomyositis	29.9	CRP CD4
17	nocardiosis	29.9	CRP CD4
18	parotitis	29.9	CRP CD4 ALB
19	brucellosis	29.9	MPO IL6 CRP
20	pelvic inflammatory disease	29.9	MPO LACTB CRP
21	horner's syndrome	29.9	F3 CRP
22	cervical adenitis	29.9	CRP CD4
23	gas gangrene	29.8	IL6 CRP ALB
24	pulmonary edema	29.8	F2 CRP ACE
25	peritonitis	29.8	MPO IL6 F2 CRP ALB
26	actinomycosis	29.8	CRP CD4 ALB
27	thrombophilia due to thrombin defect	29.8	F5 F3 F2
28	necrotizing fasciitis	29.8	INS IL6 F3 F2 CRP ALB
29	varicose veins	29.8	IL6 F5 F2
30	acute pancreatitis	29.8	MPO INS IL6 CRP
31	constrictive pericarditis	29.7	CRP ALB ACE
32	graves disease 1	29.7	INS CRP ALB
33	mucormycosis	29.7	INS IL6 CRP CD4
34	acute necrotizing pancreatitis	29.7	MPO IL6 CRP
35	pancreatitis	29.7	INS IL6 CRP ALB
36	aortic dissection	29.7	IL6 CRP ALB ACE
37	carotid stenosis	29.6	MPO CRP ACE
38	gastroesophageal reflux	29.6	MPO IL6 ATP4A ATP12A
39	blastomycosis	29.6	IL6 CRP CD4
40	multiple endocrine neoplasia, type i	29.6	INS ATP4A ATP12A
41	septic arthritis	29.6	IL6 CRP CD4 ALB
42	invasive aspergillosis	29.6	IL6 CRP CD4
43	bronchitis	29.6	MPO LACTB IL6 CRP ALB
44	disseminated intravascular coagulation	29.6	IL6 F5 F3 F2 CRP
45	adult syndrome	29.6	INS IL6 CRP
46	esophageal tuberculosis	29.6	CRP ATP4A ATP12A ALB
47	periodontitis	29.6	MPO IL6 CRP
48	lymph node tuberculosis	29.5	CRP CD4 ALB
49	leptin deficiency or dysfunction	29.5	INS IL6 CRP CD4
50	acne	29.5	INS IL6 CRP

Comorbidity relations with Mediastinitis via Phenotypic Disease Network (PDN):

Familial Atrial Fibrillation	Heart Disease
Intermediate Coronary Syndrome	Respiratory Failure

Graphical network of the top 20 diseases related to Mediastinitis:

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Symptoms & Phenotypes for Mediastinitis

UMLS symptoms related to Mediastinitis:

chest pain; signs and symptoms

MGI Mouse Phenotypes related to Mediastinitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.25	ACE ALB ATP12A ATP4A CD4 CRP
2	growth/size/body region	MP:0005378	10.11	ACE ATP12A ATP4A CD4 F2 F3
3	muscle	MP:0005369	9.98	ALB F2 F3 IL6 INS MPO
4	neoplasm	MP:0002006	9.93	ACE ALB ATP4A F3 IL6 TCF21
5	endocrine/exocrine gland	MP:0005379	9.92	ACE ALB ATP4A CD4 F2 IL6
6	cardiovascular system	MP:0005385	9.9	ACE ALB CRP F2 F3 F5
7	digestive/alimentary	MP:0005381	9.86	ALB ATP12A ATP4A CD4 F2 IL6
8	immune system	MP:0005387	9.7	ACE ALB ATP4A CD4 CRP F2
9	mortality/aging	MP:0010768	9.36	ACE ALB ATP4A CD4 F2 F3

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Drugs & Therapeutics for Mediastinitis

Drugs for Mediastinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Vaccines

Phase 2, Phase 3

2

Immunologic Factors

Phase 2, Phase 3

3

Vancomycin

Approved

1404-90-6

14969

Synonyms:

(1S,2R,18R,22S,25R,28R,40S)-22-(2-Amino-2-oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-a-L-lyxo-hexopyranosyl)-b-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylate

(1S,2R,18R,22S,25R,28R,40S)-22-(2-Amino-2-oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-a-L-lyxo-hexopyranosyl)-b-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid

(1S,2R,18R,22S,25R,28R,40S)-22-(2-Amino-2-oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylate

(1S,2R,18R,22S,25R,28R,40S)-22-(2-Amino-2-oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid

(1S,2R,18R,22S,25R,28R,40S)-22-(2-Amino-2-oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylate

(1S,2R,18R,22S,25R,28R,40S)-22-(2-Amino-2-oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid

(2.2SP,3.5SA,2.6SP)-O(4.2),C(3.4)

(2.2Sp,3.5Sa,2.6Sp)-O(4.2),C(3.4):C(5.4),O(4.6):c(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-beta-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-beta-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]

(2.2Sp,3.5Sa,2.6Sp)-O(4.2),C(3.4):C(5.4),O(4.6):c(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-b-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-a-L-lyxo-hexopyranosyl)-b-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-b-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]

(2.2Sp,3.5Sa,2.6Sp)-O(4.2),C(3.4):C(5.4),O(4.6):c(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-β-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-β-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]

Abbott brand OF vancomycin hydrochloride

AB-vancomycin

Azupharma brand OF vancomycin hydrochloride

C(5.4),O(4.6)

Cell pharm brand OF vancomycin hydrochloride

Chiesi brand OF vancomycin hydrochloride

Combino brand OF vancomycin hydrochloride

Curasan brand OF vancomycin hydrochloride

Dakota brand OF vancomycin hydrochloride

Diatracin

Dista brand OF vancomycin hydrochloride

Eli lilly brand OF vancomycin hydrochloride

Hexal brand OF vancomycin hydrochloride

Hydrochloride, vancomycin

Lilly brand OF vancomycin hydrochloride

MIP brand OF vancomycin hydrochloride

Norman brand OF vancomycin hydrochloride

Ratiopharm brand OF vancomycin hydrochloride

Sulfate, vancomycin

Vanco azupharma

Vanco-cell

Vancocin

Vancocin HCL

Vancocine

VANCOLED

Vancomicin

Vancomicina

Vancomicina abbott

Vancomicina chiesi

Vancomicina combino phar

Vancomicina norman

VANCOMYCIN

Vancomycin HCL

Vancomycin hexal

Vancomycin hydrochloride

Vancomycin lilly

Vancomycin phosphate (1:2)

Vancomycin phosphate (1:2), decahydrate

Vancomycin sulfate

Vancomycine

Vancomycine dakota

Vancomycin-ratiopharm

Vancomycinum

VANCOR

Vanco-saar

4

Meticillin

Approved, Investigational

61-32-5

6087

5

Daptomycin

Approved, Investigational

103060-53-3

16129629

6

Nitric Oxide

Approved

10102-43-9

145068

7

Creatine

Approved, Investigational, Nutraceutical

57-00-1

586

8

Anti-Infective Agents

9

Anti-Bacterial Agents

10

Antibiotics, Antitubercular

Interventional clinical trials:

(show all 14)

#	Name	Status	NCT ID	Phase	Drugs
1	A Randomized, Controlled, Phase 4 Study of Sternal Plating (Rapid Sternal Closure System, KLS Martin L.P.) in Cardiac Surgical Subjects at Higher Risk for Sternal Wound Complications.	Completed	NCT00638014	Phase 4
2	A Randomized, Multicenter, Double-Blind, Group-Sequential Study to Evaluate the Efficacy, Immunogenicity, and Safety of a Single Dose of Merck 0657nI Staphylococcus Aureus Vaccine (V710) in Adult Patients Scheduled for Cardiothoracic Surgery	Terminated	NCT00518687	Phase 2, Phase 3
3	Immunological and Bacteriological Approaches to the Development of Postoperative Mediastinitis With Staphylococcus Aureus	Unknown status	NCT03262558
4	Endoscopic - Vacuum Assisted Closure of Intrathoracic Postsurgical Leaks	Unknown status	NCT00876551
5	Delayed Primary Versus Late Secondary Wound Closure in the Treatment of Postsurgical Sternum Osteomyelitis	Unknown status	NCT01473979
6	Topical Vancomycin in Prevention of Methicillin-Resistant Staphylococcal Related Mediastinitis in Patients Receiving Coronary Artery Bypass Graft	Completed	NCT00711685
7	Post-Surgical Mediastinitis: Retrospective Study of Cases Treated Within the CHU Brugmann Hospital	Completed	NCT03922191
8	Prognostic Factors for Descending Necrotizing Mediastinitis Development in Deep Space Neck Infections - A Retrospective Study	Completed	NCT04865003
9	A Randomized, Controlled Study of Physiotherapy Exercises in Patients With Sternal Instability Due to Mediastinitis After Cardiovascular Surgery	Completed	NCT02513576
10	A Prospective, Randomized-Controlled, Multicenter Study Evaluating Primary Plating in High-Risk Median Sternotomy Patients for Osteosynthesis and Pain	Completed	NCT00819286
11	Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2	Completed	NCT02073760
12	Acute Kidney Injury During Daptomycin Versus Vancomycin Treatment in Cardiovascular Critically Ill Patients: a Propensity Score Matched Analysis	Completed	NCT03961503		Daptomycin (DAP) treatment;Vancomycin (VAN) treatment
13	Infectious Mediastinitis Among the Strasbourg Universitary Hospital, a Retrospective Cohort	Recruiting	NCT05001308
14	Experience With the Combined Method of Air-plasma Flow and Nitric Oxide Therapy in the Prevention and Treatment of Wound Infectious Complications in Cardiac Surgery	Recruiting	NCT04617353

Search NIH Clinical Center for Mediastinitis

Cochrane evidence based reviews: mediastinitis

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Genetic Tests for Mediastinitis

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Anatomical Context for Mediastinitis

Organs/tissues related to Mediastinitis:

FMA: Mediastinum

MalaCards : Heart, Kidney, Lung, Lymph Node, Bone, Trachea, Skin

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Publications for Mediastinitis

Articles related to Mediastinitis:

(show top 50) (show all 4283)

#	Title	Authors	PMID	Year
1	Periprosthetic joint infection due to Mycoplasma hominis in a multiple sclerosis patient treated with fingolimod. ⁶²	Muramatsu E...Doi Y	36064142	2022
2	A new clinical classification and reconstructive strategy for post-sternotomy surgical site infection. ⁶²	Kitano D...Sakakibara S	36382133	2022
3	Scedosporium apiospermum mediastinitis in an orthotopic heart transplant recipient. ⁶²	Saini V...Bhanot N	36277499	2022
4	Co-Management Reduces Mortality in Post-Sternotomy Mediastinitis. ⁶²	Fernandez-de-Velasco D...Alvarez-de-Arcaya A	36346276	2022
5	A Novel Case Report of Iatrogenic Tracheal Rupture Caused by a Laser-Resistant Endotracheal Tube Under Transoral Laser Laryngeal and Nasopharyngeal Surgery. ⁶²	Shimamoto Y...Kuwahara Y	36471649	2022
6	Routine Donor and Recipient Screening for Mycoplasma hominis and Ureaplasma Species in Lung Transplant Recipients. ⁶²	Vijayvargiya P...Beam E	36467297	2022
7	Management of pediatric sternal wounds following congenital heart surgery: The role of the plastic surgeon in debridement and closure. ⁶²	Horriat NL...Hoppe IC	35979680	2022
8	Predictors of prolonged hospitalization in modified sternoplasty following postoperative mediastinitis. ⁶²	Arazi M...Kachel E	36378944	2022
9	Mortality after sternal reconstruction with pectoralis major flap vs omental flap for postsurgical mediastinitis: A systematic review and meta-analysis. ⁶²	Cancelli G...Gaudino M	36378934	2022
10	Traumatic chest wall pyomyositis presenting with mediastinitis. ⁶²	Sugunesegran R...Davis PJ	36389440	2022
11	Idiopathic focal fibrosing mediastinitis with unilateral pulmonary arterial and venous involvement. ⁶²	Pujitha V...Kumar S	36378938	2022
12	An Unusual Clinical Outcome and Surgical Intervention for Mediastinal Histoplasmosis. ⁶²	Katsiroubas J...Harrison S	36465220	2022
13	A novel model for predicting mortality in the management of deep neck infections. ⁶²	Tao X...Liu Y	36318220	2022
14	Evaluation of clinical parameters affecting the prognosis in surgically treated patients with descending necrotizing mediastinitis - A retrospective study. ⁶²	Brajkovic D...Aleksandar K	35580784	2022
15	Fibrosing mediastinitis in a child with Mendelian susceptibility to mycobacterial disease possibly due to Bacillus Calmette-Guérin. ⁶²	Sharifinejad N...Velayati AA	36397171	2022
16	Esophagomediastinal fistula: a rare case of gastrointestinal tuberculosis. ⁶²	Pereira JP...Soares J	35485249	2022
17	Incidence and Risk Factors for Infectious Complications of EBUS-TBNA: Prospective Multicenter Study. ⁶²	Serra Mitja P...Andreo Garcia F	36446657	2022
18	Mucosal Injury During Per-oral Endoscopic Myotomy: A Single-Center Experience. ⁶²	Yeniova AO...Cho JY	36098360	2022
19	Cervico-thoracic cellulitis at the Yalgado Ouedraogo University Hospital: About 50 cases. ⁶²	Mathieu M...Tarcissus K	35853556	2022
20	Skin Manifestations in Patients with Selective Immunoglobulin E Deficiency. ⁶²	Picado C...Mascaro JM	36431272	2022
21	Incidence and challenges in management of hemodialysis catheter-related infections. ⁶²	Hajji M...Abderrahim E	36446808	2022
22	Effect of waiting time for COVID-19 screening on postoperative outcomes of type A aortic dissection: An institutional study. ⁶²	Hishikawa T...Yamauchi H	35971227	2022
23	A Potential Complication After Drainage in Odontogenic Descending Necrotizing Mediastinitis: Chyle Leakage. ⁶²	Lou Y...Wang H	35067529	2022
24	Risk Factors Associated with Post-Operative Complications in Multidisciplinary Treatment of Descending Necrotizing Mediastinitis. ⁶²	Congedo MT...Meacci E	36362592	2022
25	Video-assisted thoracoscopic mediastinotomy for the treatment of mediastinitis in a patient with azygos lobe. ⁶²	Lee KY...Wang BY	35568613	2022
26	A First Suspected Case of Fibrosing Mediastinitis After Anti-PD-1 Therapy. ⁶²	Park CJ...Pokharel Y	36299648	2022
27	A rare case: Descending necrotizing mediastinitis. ⁶²	Ayvaci BM...Gokdag E	36353386	2022
28	Omental Flap for Complex Sternal Wounds and Mediastinal Infection Following Cardiac Surgery. ⁶²	Li J...Schmid C	36257544	2022
29	Non-infectious sternal dehiscence after coronary artery bypass surgery. ⁶²	Silverborn M...Gudbjartsson T	36192764	2022
30	[Idiopathic and Iatrogenic Esophageal Rupture]. ⁶²	Nakano T	36155588	2022
31	Relationship between mysticism and severe odontogenic infections in Africa: what to do? ⁶²	Filipe L...Teixeira RG	35431178	2022
32	Observation of Retropharyngeal Fluid Collection in 2 COVID-19 Positive Patients. ⁶²	Steehler AJ...Moore CE	33155845	2022
33	Mediastinitis after a cryopreserved allograft tracheal transplant treated by transposition of the major omentum. ⁶²	Gomez-Caro A...Berthet JP	36005860	2022
34	Video-assisted thoracoscopic surgery for a pediatric patient with descending necrotizing mediastinitis. ⁶²	Saito Y...Komaru S	36247887	2022
35	Survival rate of odontogenic descending necrotizing mediastinitis. Our experience in last 5 years. ⁶²	Sada-Urmeneta A...Navarro-Cuellar I	36173718	2022
36	Enhanced strategy against mediastinitis with thoracic vascular graft infection: A combination of hydro-debridement with pulsed lavage and negative pressure wound therapies. ⁶²	Takagi D...Yamamoto H	35771228	2022
37	Descending mediastinitis mimicking a pharyngo-laryngeal neoplasia. ⁶²	Valverde-Jorge R...Rodeno-Ortiz de Zarate E	36162746	2022
38	Impact of a Surgical Wound Infection Prevention Bundle in Pediatric Cardiothoracic Surgery. ⁶²	Glenn ET...Ware AL	36126719	2022
39	Role of early extraction of odontogenic focus in deep neck infections. ⁶²	Trevino-Gonzalez JL...Morales-Del-Angel JA	36173714	2022
40	Delayed Diagnosis of Pediatric Sternoclavicular Joint Infections and Clavicular Osteomyelitis During the COVID-19 Pandemic: A Report of 3 Cases. ⁶²	Benson EM...Williams KA	36166203	2022
41	Ludwig's angina: An alarming radiology challenge. ⁶²	Gunawan F...Ferriastuti W	35784784	2022
42	Management of failing bidirectional cavopulmonary shunt: Influence of additional systemic-to-pulmonary-artery shunt with classic Glenn physiology. ⁶²	Euringer C...Ono M	36172411	2022
43	The rare case of oesophago-pericardial fistula secondary to pulmonary tuberculosis. ⁶²	Sidhu KK...Yeo DA	36168442	2022
44	[Acute Mediastinitis]. ⁶²	Obuchi T	36155583	2022
45	Acute Suppurative Thyroiditis (AST) With Thyroid Abscess: A Rare and Potentially Fatal Neck Infection. ⁶²	Sanker V...Jadhav C	36249640	2022
46	Esophageal Perforation Accompanying Mediastinitis in Blunt Trauma in a Patient with Thoracic Osteophytes. ⁶²	Suzuki K...Imai H	35135923	2022
47	[Coronary Artery Bypass Grafting via Partial Sternotomy Late after Partial Chest Wall Resection:Report of a Case]. ⁶²	Nakata K...Fukui T	35892306	2022
48	Management of descending necrotizing mediastinitis with severe thoracic empyema using minimally invasive video-assisted thoracoscopic surgery: a case report. ⁶²	Zhang Y...Guo F	36072533	2022
49	A Community-Based Pancreatic Cancer Screening Study in High-Risk Individuals: Preliminary Efficacy and Safety Results. ⁶²	Kandiah J...Frank RC	35854467	2022
50	[Initial and Long-term Results of Omental Flap Coverage for the Complications after Thoracic Aortic Aneurysm Repair]. ⁶²	Midorikawa H...Kanno M	35892295	2022

Sources

Genes for Mediastinitis

Genes related to Mediastinitis (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MPO	Myeloperoxidase	Protein Coding	10.96	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
2	F5	Coagulation Factor V	Protein Coding	7.44	GeneCards inferred via : Publications (show sections)
3	LACTB	Lactamase Beta	Protein Coding	7.44	GeneCards inferred via : Publications (show sections)
4	CRP	C-Reactive Protein	Protein Coding	7.41	DISEASES inferred ¹⁴
5	ATP12A	ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit	Protein Coding	6.73	DISEASES inferred ¹⁴
6	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	6.73	DISEASES inferred ¹⁴
7	ALB	Albumin	Protein Coding	5.78	DISEASES inferred ¹⁴
8	INS	Insulin	Protein Coding	5.59	DISEASES inferred ¹⁴
9	F2	Coagulation Factor II, Thrombin	Protein Coding	5.3	DISEASES inferred ¹⁴
10	TCF21	Transcription Factor 21	Protein Coding	5.24	DISEASES inferred ¹⁴
11	F3	Coagulation Factor III, Tissue Factor	Protein Coding	5.08	DISEASES inferred ¹⁴
12	CD4	CD4 Molecule	Protein Coding	4.84	DISEASES inferred ¹⁴
13	ACE	Angiotensin I Converting Enzyme	Protein Coding	4.74	DISEASES inferred ¹⁴
14	IL6	Interleukin 6	Protein Coding	4.67	DISEASES inferred ¹⁴

Sources

Variations for Mediastinitis

Sources

Expression for Mediastinitis

Search GEO for disease gene expression data for Mediastinitis.

Sources

Pathways for Mediastinitis

Pathways related to Mediastinitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.15	MPO IL6 F2 CD4
2	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁶ Show member pathways Post-translational protein phosphorylation ⁶⁶	11.82	IL6 F5 F2 ALB
3	Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers ⁶⁵	11.7	INS IL6 ALB
4	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.61	MPO IL6 CD4
5	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.32	IL6 CRP CD4
6	FOXA2 and FOXA3 transcription factor networks ⁶¹ Show member pathways FOXA transcription factor networks ⁶¹	10.77	INS F2 ALB
7	Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction ⁶⁰	10.37	F3 F2 CD4

Sources

GO Terms for Mediastinitis

Cellular components related to Mediastinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.96	MPO INS IL6 F5 F3 F2
2	endoplasmic reticulum lumen	GO:0005788	9.4	INS IL6 F5 F2 CD4 ALB

Biological processes related to Mediastinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	neutrophil mediated immunity	GO:0002446	9.56	IL6 ACE
2	acute-phase response	GO:0006953	9.23	INS IL6 F2 CRP
3	regulation of body fluid levels	GO:0050878	9.16	F5 F2
4	hemostasis	GO:0007599	9.13	F5 F3 F2

Molecular functions related to Mediastinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	P-type sodium:potassium-exchanging transporter activity	GO:0005391	9.46	ATP4A ATP12A
2	P-type potassium transmembrane transporter activity	GO:0008556	8.96	ATP4A ATP12A
3	P-type potassium:proton transporter activity	GO:0008900	8.92	ATP4A ATP12A

Sources

Sources for Mediastinitis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: MDS022 MIFTS: 46	Mediastinitis	Data Licensing For inquiries, contact: [email protected]
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