Mediastinitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MDS022 MIFTS: 47	Mediastinitis
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Aliases & Classifications for Mediastinitis

MalaCards integrated aliases for Mediastinitis:

Name: Mediastinitis ¹² ⁴⁴ ¹⁵ ⁷⁰

External Ids:

Disease Ontology ¹² DOID:819

ICD9CM ³⁴ 519.2

MeSH ⁴⁴ D008480

NCIt ⁵⁰ C26827

SNOMED-CT ⁶⁷ 47597000

ICD10 ³² J98.51

UMLS ⁷⁰ C0025064

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Summaries for Mediastinitis

Disease Ontology : ¹² A connective tissue disease characterized by inflammation located in the mediastinum, which extends from the diaphragm to the thoracic inlet and between the pleural cavities.

MalaCards based summary : Mediastinitis is related to epiglottitis and hemopericardium, and has symptoms including chest pain and signs and symptoms. An important gene associated with Mediastinitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Vitamin D and Alfacalcidol have been mentioned in the context of this disorder. Affiliated tissues include mediastinum, lymph node and lung, and related phenotypes are cardiovascular system and digestive/alimentary

Wikipedia : ⁷³ Mediastinitis is inflammation of the tissues in the mid-chest, or mediastinum. It can be either acute or... more...

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Related Diseases for Mediastinitis

Diseases related to Mediastinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 753)

#	Related Disease	Score	Top Affiliating Genes
1	epiglottitis	30.5	LACTB CRP
2	hemopericardium	30.3	F3 F2 CRP
3	pleural empyema	30.2	F2 CRP CD4 ALB
4	constrictive pericarditis	30.2	CRP ALB
5	pharyngitis	30.1	LACTB CRP CD4
6	endocarditis	30.1	LACTB F2 CRP ALB
7	laryngitis	30.1	CRP ATP4A ATP12A
8	pulmonary hypertension	30.0	F3 F2 CRP ALB
9	acute pancreatitis	30.0	MPO INS CRP
10	adult respiratory distress syndrome	30.0	MPO F5 F2
11	peritonitis	30.0	MPO F2 CRP ALB
12	lemierre's syndrome	29.9	F3 F2 CRP
13	esophageal tuberculosis	29.9	ATP4A ATP12A
14	pneumonia	29.9	MPO LACTB CRP ALB
15	intermediate coronary syndrome	29.9	INS F3 CRP
16	cardiac tamponade	29.9	F3 F2 CRP ALB
17	heart aneurysm	29.9	CRP ALB
18	mitral valve stenosis	29.8	F3 F2 CRP
19	tracheomalacia	29.8	ATP4A ATP12A
20	pelvic inflammatory disease	29.8	MPO LACTB CRP
21	gastroesophageal reflux	29.8	MPO ATP4A ATP12A
22	angina pectoris	29.8	INS F3 CRP
23	bronchitis	29.8	MPO LACTB CRP ALB
24	disseminated intravascular coagulation	29.8	F5 F3 F2 CRP
25	meningitis	29.7	LACTB CRP ALB
26	disease by infectious agent	29.7	LACTB CRP CD4 ALB
27	gastroenteritis	29.7	LACTB CRP ALB
28	peptic esophagitis	29.7	ATP4A ATP12A ALB
29	chickenpox	29.7	CRP CD4 ALB
30	polyneuropathy	29.6	INS CRP ALB
31	pyomyositis	29.6	CRP CD4
32	atrial heart septal defect	29.6	F3 F2 CRP ALB
33	pyuria	29.6	F2 CRP ALB
34	sclerosing cholangitis	29.6	MPO F2 ALB
35	lymph node tuberculosis	29.6	CRP CD4
36	parotitis	29.5	CRP CD4 ALB
37	facial paralysis	29.5	CRP CD4 ALB
38	otitis media	29.5	MPO LACTB CRP ALB
39	cervical adenitis	29.5	CRP CD4
40	bartonellosis	29.5	CRP CD4
41	suppurative thyroiditis	29.5	INS CRP CD4
42	mucormycosis	29.5	INS CRP CD4 ALB
43	acquired immunodeficiency syndrome	29.4	CRP CD4 ALB
44	diverticulitis	29.4	CRP ATP4A ATP12A ALB
45	nocardiosis	29.4	LACTB CRP CD4
46	purpura	29.4	F3 F2 CRP
47	bone inflammation disease	29.4	INS CRP CD4 ALB
48	pulmonary disease, chronic obstructive	29.4	MPO INS CRP CD4 ALB
49	congestive heart failure	29.4	INS CRP ALB
50	lung abscess	29.3	LACTB CRP CD4 ALB

Comorbidity relations with Mediastinitis via Phenotypic Disease Network (PDN):

Familial Atrial Fibrillation	Heart Disease
Intermediate Coronary Syndrome	Respiratory Failure

Graphical network of the top 20 diseases related to Mediastinitis:

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Symptoms & Phenotypes for Mediastinitis

UMLS symptoms related to Mediastinitis:

chest pain; signs and symptoms

MGI Mouse Phenotypes related to Mediastinitis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.76	ALB CRP F2 F3 F5 INS
2	digestive/alimentary	MP:0005381	9.43	ALB ATP12A ATP4A CD4 F2 INS
3	homeostasis/metabolism	MP:0005376	9.36	ALB ATP12A ATP4A CD4 CRP F2

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Drugs & Therapeutics for Mediastinitis

Drugs for Mediastinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 106)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Vitamin D

Approved, Nutraceutical, Vet_approved

Phase 4

1406-16-2

Alfacalcidol

Approved, Nutraceutical

Phase 4

41294-56-8

5282181

Hydroxycholecalciferols

Phase 4

Nutrients

Phase 4

Trace Elements

Phase 4

Micronutrients

Phase 4

Vitamins

Phase 4

Calciferol

Phase 4

Oxaliplatin

Approved, Investigational

Phase 2, Phase 3

61825-94-3

5310940 9887054 43805 6857599

Tranexamic Acid

Approved

Phase 3

1197-18-8

5526

Dacarbazine

Approved, Investigational

Phase 2, Phase 3

4342-03-4

5351166 2942

Vinblastine

Approved

Phase 2, Phase 3

865-21-4

241903 13342

Nedaplatin

Approved, Investigational

Phase 3

95734-82-0

Sargramostim

Approved, Investigational

Phase 3

123774-72-1, 83869-56-1

Lenograstim

Approved, Investigational

Phase 3

135968-09-1

Hydrocortisone

Approved, Vet_approved

Phase 3

50-23-7

5754

Hydrocortisone acetate

Approved, Vet_approved

Phase 3

50-03-3

nivolumab

Approved

Phase 3

946414-94-4

Fluorouracil

Approved

Phase 3

51-21-8

3385

Cortisone

Experimental

Phase 3

53-06-5

222786

Pharmaceutical Solutions

Phase 3

Antifibrinolytic Agents

Phase 3

Hemostatics

Phase 3

Coagulants

Phase 3

Fibrin Tissue Adhesive

Phase 3

Immunoglobulins, Intravenous

Phase 3

Adjuvants, Immunologic

Phase 3

Hydrocortisone-17-butyrate

Phase 3

Hydrocortisone hemisuccinate

Phase 3

Hydrocortisone 17-butyrate 21-propionate

Phase 3

Liver Extracts

Phase 3

Vaccines

Phase 2, Phase 3

Midazolam

Approved, Illicit

Phase 2

59467-70-8

4192

Decitabine

Approved, Investigational

Phase 1, Phase 2

2353-33-5

451668

Dexlansoprazole

Approved, Investigational

Phase 2

138530-94-6, 103577-45-3

9578005

Omeprazole

Approved, Investigational, Vet_approved

Phase 2

73590-58-6

4594

Lansoprazole

Approved, Investigational

Phase 2

103577-45-3

3883

Celecoxib

Approved, Investigational

Phase 2

169590-42-5

2662

Dexamethasone

Approved, Investigational, Vet_approved

Phase 2

50-02-2

5743

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 2

1177-87-3

Cytarabine

Approved, Investigational

Phase 2

147-94-4

6253

Teniposide

Approved

Phase 2

29767-20-2

34698

Methotrexate

Approved

Phase 2

1959-05-2, 59-05-2

126941

Vindesine

Approved, Investigational

Phase 2

59917-39-4, 53643-48-4

40839

Paclitaxel

Approved, Vet_approved

Phase 2

33069-62-4

36314

Zanubrutinib

Approved, Investigational

Phase 2

1691249-45-2

Pembrolizumab

Approved

Phase 2

1374853-91-4

Durvalumab

Approved, Investigational

Phase 2

1428935-60-7

Raltitrexed

Approved, Investigational

Phase 1, Phase 2

112887-68-0

104758

Fludarabine

Approved

Phase 1, Phase 2

21679-14-1, 75607-67-9

30751

Interventional clinical trials:

(show top 50) (show all 192)

#	Name	Status	NCT ID	Phase	Drugs
1	Atrial Fibrillation and Pericardial Drainage: Incidence of Postoperative Atrial Fibrillation According to the Type of Mediastinal Drainage Catheters	Unknown status	NCT02808897	Phase 4
2	Short Term Effect of Vitamin D Supplementation on the Clinical Outcomes in Patients Undergoing Valve Replacement Surgery	Completed	NCT04085770	Phase 4	Alfacalcidol 1 MCG Oral Capsule
3	A Randomized, Controlled, Phase 4 Study of Sternal Plating (Rapid Sternal Closure System, KLS Martin L.P.) in Cardiac Surgical Subjects at Higher Risk for Sternal Wound Complications.	Completed	NCT00638014	Phase 4
4	Conventional Versus Ultrasound-guided Transbronchial Needle Aspiration, Using Rapid On-site Cytological Evaluation, for the Diagnosis of Hilar/Mediastinal Enlarged Lymph Nodes: a Randomized Controlled Trial.	Completed	NCT01658280	Phase 4
5	123-I mIBG (AdreView) Heart-to-Mediastinal (H/M) Ratio and SPECT Imaging	Completed	NCT01868841	Phase 4	AdreView
6	Efficacy and Safety Study of the Combined Modality Therapy in Patients With Potentially Resectable, Locally Advanced Adenocarcinoma of the Esophago-gastric Junction With Preoperative Chemo- and Chemoradiation Followed by Surgical Resection	Unknown status	NCT01523015	Phase 2, Phase 3
7	Randomized Control Study on Surgical Treatment for Middle and Lower Thoracic Esophageal Cancer Patients Without Upper Mediastinal Lymph Node Metastasis Through Left Versus Right Transthoracic Approach	Unknown status	NCT02448979	Phase 3
8	Endosonography (EUS and EBUS) vs Conventional Bronchoscopy for the Diagnosis of Sarcoidosis: a Randomized Trial	Completed	NCT00872612	Phase 3
9	Topical Application of Tranexamic Acid to Reduce Post-operative Bleeding in Coronary Artery Bypass Surgery	Completed	NCT01519245	Phase 3	Tranexamic Acid;normal saline
10	A Randomized Controlled Trial of Endobronchial or Endoscopic Ultrasound as a First Test in the Diagnosis and Staging of Lung Cancer	Completed	NCT00652769	Phase 3
11	A Randomized Phase III Study of Sequential High-Dose Cisplatinum/Etoposide/Ifosfamide Plus Stem Cell Support Versus BEP in Patients With Poor Prognosis Germ Cell Cancer	Completed	NCT00003941	Phase 3	cisplatin;etoposide;ifosfamide
12	Early Salvage With High Dose Chemotherapy and Stem Cell Transplantation in Advanced Stage Hodgkin's Lymphoma Patients With Positive PET After Two Courses of ABVD (PET-2 Positive) and Comparison of RT Versus no RT in PET-2 Negative Patients	Completed	NCT00784537	Phase 2, Phase 3	ABVD;ABVD and Radiotherapy
13	Randomized Trial of Mediastinal Lymph Node Sampling Versus Complete Lymphadenectomy During Pulmonary Resection in the Patient With N0 and N1 (Less Than Hilar) Non-Small Cell Carcinoma	Completed	NCT00003831	Phase 3
14	Improving Preoperative Lung Cancer Staging Through the Canada Lymph Node Project: A Pan-Canadian Multicentered Crossover Trial	Recruiting	NCT04342377	Phase 3
15	Postoperative Pain and Quality of Life for Patients Undergoing Mediastinal Tumor Resection by Subxiphoid and Intercostal VATS：A Randomized Controlled Trial	Recruiting	NCT03521986	Phase 3
16	A Multicenter Prospective Randomized Controlled Study of Porcine Fibrin Sealant in Preventing Cervical Anastomotic Leakage for Esophageal or Junctional Carcinoma. (PLACE030)	Recruiting	NCT03847857	Phase 3
17	OMEGA, A Randomized Trial of Local Ablative Therapy Vs. Conventional Treatment in Oligometastatic NSCLC	Recruiting	NCT03827577	Phase 3	Standard medical therapy
18	A Phase III Clinical Trial of Docetaxel Plus Cisplatin Versus Vinorelbine Plus Cisplatin in Neoadjuvant Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma	Recruiting	NCT02465736	Phase 3	Docetaxel;Cisplatin;Vinorelbine;Cisplatin
19	A Prospective Clinical Trial of Improving the Treatment of Thoracic Esophageal Cancer	Active, not recruiting	NCT01137123	Phase 3	adjuvant chemotherapy
20	Preoperative Chemoradiotherapy vs. Chemotherapy Alone in Non-small Cell Lung Cancer (NSCLC) Patients With Mediastinal Lymph Node Metastases (Stage IIIA, N2): A Randomized Prospective Phase III Trial	Active, not recruiting	NCT00030771	Phase 3	Chemotherapy
21	Phase III Study Comparing Post-Operative Conformal Radiotherapy to No Post-Operative Radiotherapy in Patients With Completely Resected Non-Small Cell Lung Cancer and Mediastinal N2 Involvement [Lung ART]	Active, not recruiting	NCT00410683	Phase 3
22	A Randomized Phase 3 Trial of Nivolumab (NSC# 748726) in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma	Not yet recruiting	NCT04759586	Phase 3	Cyclophosphamide;Doxorubicin Hydrochloride;Etoposide Phosphate;Prednisolone;Prednisone;Vincristine Sulfate
23	Systemic Therapy With or Without Local Radiotherapy for Extracranial Oligometastatic Breast Cancer	Not yet recruiting	NCT04646564	Phase 3	standard of care
24	Adjuvant Radiotherapy for T3N0M0 Esophageal Squamous Cell Carcinoma With Positive Circumstantial Resection Margin(a Randomized Controlled Trial)	Not yet recruiting	NCT03273647	Phase 3
25	A Randomized, Multicenter, Double-Blind, Group-Sequential Study to Evaluate the Efficacy, Immunogenicity, and Safety of a Single Dose of Merck 0657nI Staphylococcus Aureus Vaccine (V710) in Adult Patients Scheduled for Cardiothoracic Surgery	Terminated	NCT00518687	Phase 2, Phase 3
26	Possibilities for Improvement of an Outcome of the Treatment in Squamous Cell Carcinoma of the Thoracic Esophagus - a Multicenter Randomized Clinical Phase III Trial.	Terminated	NCT00559351	Phase 3	neoadjuvant chemotherapy (cisplatin, 5-fluorouracil)
27	Combined Chemotherapy and PD-1 Antibody(SHR-1210) With or Without Low-dose Decitabine Priming for Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma (rrPMBCL):Two Stage, Phase I/II Trail	Unknown status	NCT03346642	Phase 1, Phase 2	Decitabine;GVD chemotherapy;SHR-1210
28	Phase II Study of Extensive Clinical Target Volumes in Postoperative Radiotherapy for Esophageal	Unknown status	NCT02384811	Phase 2
29	A Study of Prophylactic Oral Steroids for Fatigue and Malaise Due to Regorafenib Treatment for Unresectable Metastatic Colorectal Cancer: a Randomized, Placebo-controlled, Double-blind Phase 2 Clinical Study (KSCC1402/HGCSG1402)	Unknown status	NCT02288078	Phase 2	Dexamethasone;Regorafenib;Placebo;Proton pump inhibitor
30	Preoperative Chemoradiotherapy vs. Chemotherapy Alone in Nonsmall Cell Lung Cancer (NSCLC) Patients With Mediastinal Lymph Node Metastases (Stage IIIA, N2): A Randomized Prospective Phase II Trial	Unknown status	NCT01187290	Phase 2
31	A Phase II Study Of Preoperative Celecoxib/Paclitaxel/Carboplatin For Squamous Cell And Adenocarcinoma Of The Esophagus	Completed	NCT00066716	Phase 2	carboplatin;celecoxib;paclitaxel
32	A Phase II Study of Pembrolizumab (MK-3475) in Subjects With Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma (rrPMBCL) or Relapsed or Refractory Richter Syndrome (rrRS)	Completed	NCT02576990	Phase 2
33	A Phase I/II Study Of Brentuximab Vedotin In Combination With Multi-Agent Chemotherapy As Front-Line Treatment In Patients With CD30 Positive Primary Mediastinal Large B-Cell, Diffuse Large B-Cell, And Grey Zone Lymphomas	Completed	NCT01994850	Phase 1, Phase 2	brentuximab vedotin
34	A Phase II Study of SGN-35 (Brentuximab Vedotin) of Patients With Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma (PMLBCL)	Completed	NCT02423291	Phase 2	Brentuximab Vedotin
35	Prospective Controlled Trial of Mediastinoscopy Compared With Endobronchial Ultrasound Guided Transbronchial Needle Aspiration for Assessment of the Mediastinum in Lung Cancer.	Completed	NCT00372203	Phase 2
36	A Pilot Study With Cetuximab and Radiation Therapy for Patients With Surgically Resectable Esophageal and GE Junction Carcinomas: Hoosier Oncology Group Study (GI05-92)	Completed	NCT00319735	Phase 2
37	Multicentre Study to Optimize Therapy of Burkitt's Leukemia (B-ALL) and Non-Hodgkin Lymphoma	Completed	NCT01290120	Phase 2	Chemotherapy-Rituximab combination
38	Cisplatin-Docetaxel Induction Plus Concurrent 3-D Conformal Radiotherapy and Weekly Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer Patients: A Phase II Trial	Completed	NCT03371550	Phase 2	Docetaxel;Cisplatin
39	Preoperative Chemotherapy in Non-Small Cell Lung Cancer (NSCLC) Patients With Mediastinal Lymph Node Metastases (Stage IIIA, N2)	Completed	NCT00003231	Phase 2	cisplatin;docetaxel
40	Diagnostic Utility of Endobronchial Ultrasound Guided Mediastinal Lymph Node Sampling in Clinical Stage I and II Non Small Cell Lung Cancer	Completed	NCT00832715	Phase 1, Phase 2
41	Pilot Study of Ruxolitinib in Relapsed or Refractory Hodgkin Lymphoma and Primary Mediastinal Large B-cell Lymphoma	Completed	NCT01965119	Phase 2	Ruxolitinib
42	A Phase II Study on the Safety and Efficacy of Zanubrutinib Combined With Tislelizumab in the Treatment of Relapsed/Refractory Primary Mediastinal Large B-cell Lymphoma and Epstein-Barr Virus-positive Diffuse Large B-cell Lymphoma	Recruiting	NCT04705129	Phase 2	Zanubrutinib;Tislelizumab
43	Phase II Study of Pembrolizumab and Fractionated External Beam Radiotherapy in Patients With Relapsed and Refractory Non-Hodgkin Lymphoma	Recruiting	NCT03210662	Phase 2
44	LCI-LUN-NSC-SBRT-001: Phase II Prospective Trial of Primary Lung Tumor Stereotactic Body Radiation Therapy Followed by Concurrent Mediastinal Chemoradiation for Locally-Advanced Non-Small Cell Lung Cancer	Recruiting	NCT03141359	Phase 2	Carboplatin;Paclitaxel;cis Platinum;Etoposide;Durvalumab
45	A Feasibility Study Evaluating Neoadjuvant Hemithoracic Intensity Modulated Radiation Therapy for Surgically Resectable Malignant Pleural Mesothelioma	Recruiting	NCT00797719	Phase 1, Phase 2
46	Phase I/II Study of Anti-CD19 Chimeric Antigen Receptor-Expressing T Cells in Pediatric Patients Affected by Relapsed/Refractory CD19+ Acute Lymphoblastic Leukemia and Diffuse Large B Cell Lymphoma (DLBCL) or Primary Mediastinal B Cell Lymphoma (PML)	Recruiting	NCT04787263	Phase 1, Phase 2
47	Comparison of Safety and Efficacy Among "3-Hole" Subxiphorid Approach, Trans Sternal Approach and VATS in Surgical Treatment of Anterior Mediastinal Tumor	Recruiting	NCT02317224	Phase 2
48	Phase 2 Study of Copanlisib in Combination With Nivolumab in Subjects With Relapsed/Refractory Diffuse Large B-Cell Lymphoma and Primary Mediastinal Large B-Cell Lymphoma	Recruiting	NCT03484819	Phase 2	Copanlisib Hydrochloride
49	An Assessment of the Safety and Feasibility of Administering T-Cells Expressing an Anti-CD19 Chimeric Antigen Receptor to Patients With B-Cell Lymphoma	Active, not recruiting	NCT00924326	Phase 1, Phase 2	Fludarabine;Cyclophosphamide;Aldesleukin;Fludarabine;Cyclophosphamide
50	Intergroup Trial for Children or Adolescents With B-Cell NHL or B-AL: Evaluation of Rituximab Efficacy and Safety in High Risk Patients - Phase II Trial of DA-EPOCH-Rituximab in PMLBL	Active, not recruiting	NCT01516567	Phase 2	Etoposide, Doxorubicin, Vincristine, Cyclophosphamide, Rituximab

Search NIH Clinical Center for Mediastinitis

Cochrane evidence based reviews: mediastinitis

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Genetic Tests for Mediastinitis

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Anatomical Context for Mediastinitis

The Foundational Model of Anatomy Ontology organs/tissues related to Mediastinitis:

¹⁹

Mediastinum

MalaCards organs/tissues related to Mediastinitis:

⁴⁰

Lymph Node, Lung, Heart, Skin, T Cells, Pancreas, Trachea

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Publications for Mediastinitis

Articles related to Mediastinitis:

(show top 50) (show all 4051)

#	Title	Authors	PMID	Year
1	Complete lung collapse as a rare complication of sarcoidosis-associated mediastinal lymphadenopathy. ⁶¹	Rishi AR...Rishi MA	33732471	2021
2	Fibrosing Mediastinitis Associated With Tuberculosis in Children. ⁶¹	Singhal KK...Singh M	33710984	2021
3	A rare case of primary angiosarcoma of the anterior mediastinum. ⁶¹	Yamazaki K...Sakata R	33222090	2021
4	Delayed onset of mediastinitis with tracheomediastinal fistula following endobronchial ultrasound-guided transbronchial needle aspiration; A case report. ⁶¹	Jang JG...Lee SS	33605045	2021
5	[Diagnosis and treatment of 12 patients with deep neck infection and inferior mediastinal infection]. ⁶¹	Chen G...Fu M	33794630	2021
6	Circumferential esophageal perforation resulting in tension hydropneumothorax in a patient with septic shock. ⁶¹	Saffo S...Nagar A	33691378	2021
7	Finding the bubble: atypical and unusual extrapulmonary air in the chest. ⁶¹	Varona Porres D...Andreu J	33678458	2021
8	Retropharyngeal Abscess. Clinical Review of Twenty-five Years. ⁶¹	Sanz Sanchez CI...Morales Angulo C	32487430	2021
9	A case of cervical fasciitis complicated by mediastinitis and pre-peritoneal abscess: the role of video-assisted thoracoscopic surgery. ⁶¹	Lenzi R...Muscatello L	33642717	2021
10	Tonsillitis, tonsillectomy, and deep neck space infections in England: the case for a new guideline for surgical and non-surgical management. ⁶¹	Pankhania M...Richards S	33645267	2021
11	Streptococcus anginosus group infection as a predictor for the progression of descending necrotizing mediastinitis. ⁶¹	Sakai T...Iyoda A	33752421	2021
12	Evaluation of Outcomes Following Pulmonary Artery Stenting in Fibrosing Mediastinitis. ⁶¹	Welby JP...Knavel-Koepsel EM	33205295	2021
13	Central venoarterial extracorporeal life support in pediatric refractory septic shock: a single center experience. ⁶¹	Ruth A...Thomas JA	33719730	2021
14	Recent developments in controlling sternal wound infection after cardiac surgery and measures to enhance sternal healing. ⁶¹	Pradeep A...Varma PK	33174619	2021
15	Monitoring the Impact of Aggressive Glycemic Intervention during Critical Care after Cardiac Surgery with a Glycemic Expert System for Nurse-Implemented Euglycemia: The MAGIC GENIE Project. ⁶¹	Rao RH...Cunningham CA	33650454	2021
16	Identification of risk factors for mortality and delayed oral dietary intake in patients with open drainage due to deep neck infections: A nationwide study using a Japanese inpatient database. ⁶¹	Hidaka H...Iwai H	33650237	2021
17	CD4+CTLs in Fibrosing Mediastinitis Linked to Histoplasma capsulatum. ⁶¹	Allard-Chamard H...Pillai S	33328214	2021
18	Successful Endovascular Repair of an Aortobronchial Fistula due to Takayasu Arteritis. ⁶¹	Kotani S...Hase M	32949744	2021
19	Development of a fully automated surgical site infection detection algorithm for use in cardiac and orthopedic surgery research. ⁶¹	Suzuki H...Schweizer ML	33618788	2021
20	Is the Obesity Paradox in Cardiac Surgery Really a Myth? Effect of Body Mass Index on Early and Late Clinical Outcomes. ⁶¹	Burgos LM...Navia D	32423731	2021
21	A new classification of descending necrotizing mediastinitis and surgical strategies. ⁶¹	Guan X...Zhang W	33708983	2021
22	Therapeutic drug monitoring of flucytosine in a cardiac transplant patient receiving continuous veno-venous hemofiltration and intermittent hemodialysis: A case report. ⁶¹	Williams KN...Gandhi RG	33527677	2021
23	Ruptured mediastinal mature teratoma causing severe mediastinitis: report of a surgically resected case and a literature review. ⁶¹	Nakajima E...Ikeda N	33591407	2021
24	Outcomes of primary sternal closure for postoperative mediastinitis in children. ⁶¹	Tsuji S...Koizumi J	33576375	2021
25	Treatment and Chest Reconstruction for Mediastinitis Following Sternotomy for Cardiac Surgery at the Heart Institute of the University of São Paulo Medical School. ⁶¹	Pagotto VPF...Jatene FB	33577255	2021
26	Mediastinitis Secondary to Peripherally Inserted Central Catheter Migration and Perforation after Minor Trauma: A Case Report. ⁶¹	Martinez O...Puller J	33560956	2021
27	Ascending Necrotizing Mediastinitis. An Exceptional Case. ⁶¹	Sanchez-Matas C...Jimenez-Sanchez M	33714658	2021
28	[Descending Necrotising Mediastinitis: the Choice of Drainage]. ⁶¹	Safranek J...Hosek P	33535266	2021
29	A date pit induced aorto-oesophageal fistula: a case report and concise literature review. ⁶¹	Lichtenstein KM...Brar HS	33614050	2021
30	Prevention of Sternal Wound Infections in Women Using an External Sternum Fixation Corset. ⁶¹	Selten K...Tewarie L	32611929	2021
31	Endoscopic recanalization of complete esophageal obstruction. ⁶¹	Vitali F...Rath T	33523266	2021
32	Treatment of Pediatric Sternotomy Wound Complications: A Minimally Invasive Approach. ⁶¹	Jo T...Kim EK	33540426	2021
33	Relationship between adverse events associated with lenvatinib treatment for thyroid cancer and patient prognosis. ⁶¹	Iwasaki H...Matsui A	33414909	2021
34	Is vacuum-assisted closure therapy feasible for children with deep sternal wound infection after cardiac surgery? The pooling results from current literature. ⁶¹	Wu Y...Wei G	33569832	2021
35	Accidental breakage of needle tip during endobronchial ultrasound-guided transbronchial needle aspiration: A case report and review of literature. ⁶¹	Bante N...Suri JC	33402643	2021
36	Case Report: 18F-FDG PET-CT for Diagnosing Prosthetic Device-Related Infection in an Infant With CHD. ⁶¹	Kawamura J...Kawano Y	33763393	2021
37	Eradication of Staphylococcus aureus post-sternotomy mediastinitis following the implementation of universal pre-operative nasal decontamination with mupirocin: an interrupted time-series analysis. ⁶¹	San-Juan R...Aguado JM	33513221	2021
38	Ptosis and Miosis Associated with Fibrosing Mediastinitis. ⁶¹	Ahmed S...AlAbbas A	33431787	2021
39	Successful management of anastomotic leakage with endoscopic fibrin glue injection after primary repair of pure oesophageal atresia. ⁶¹	Roy C...Gabra H	33509880	2021
40	Focal Mediastinitis and Pulmonary Arterial Thrombosis after EBUS-TBNA. ⁶¹	Palomeque A...Agusti C	32798007	2021
41	[Treatment of postoperative anterior mediastinitis, sternal osteomyelitis in a patient with a novel coronavirus infection]. ⁶¹	Kabanov MY...Sementsov KV	33759469	2021
42	Surgical treatment of mediastinitis: The vertical bolstered Donati stitch. ⁶¹	Repossini A...Benussi S	33577144	2021
43	Staphylococcus aureus mediastinitis due to subclavian vein perforation and catheter-related-infection. ⁶¹	Riviere P...Marie G	33473350	2021
44	Successful treatment of left ventricular patch infection by latissimus dorsi muscle flap covering without patch removal. ⁶¹	Mori K...Nakamura K	32613497	2021
45	Immune reconstitution inflammatory syndrome in Mycobacterium chimaera mediastinitis: When clinical judgment trumps imaging. ⁶¹	Haddad S...Santoro J	33707377	2021
46	Effects of intravenous and transdermal photobiomodulation on the postoperative complications of coronary artery bypass grafting surgery: a randomized, controlled clinical trial. ⁶¹	Kazemikhoo N...Ghaffarinejad MH	33398614	2021
47	Clinical investigation of nosocomial infections in adult patients after cardiac surgery. ⁶¹	Liu Z...Zhai Q	33530207	2021
48	Severe parapharyngeal abscess that developed significant complications: management during the COVID-19 pandemic. ⁶¹	Ajeigbe T...Mattine S	33370968	2020
49	Initial clinical experience with minimally invasive surgical aortic valve replacement. ⁶¹	Abjigitova D...Bogers AJ	33302611	2020
50	Kazachstania slooffiae: An unexpected journey to a human pleural sample. ⁶¹	Mercier V...Sasso M	33422936	2020

Sources

Genes for Mediastinitis

Genes related to Mediastinitis (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CRP	C-Reactive Protein	Protein Coding	7.44	DISEASES inferred ¹⁵
2	MPO	Myeloperoxidase	Protein Coding	6.93	GeneCards inferred via : Publications (show sections)
3	ATP12A	ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit	Protein Coding	6.75	DISEASES inferred ¹⁵
4	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	6.75	DISEASES inferred ¹⁵
5	F5	Coagulation Factor V	Protein Coding	6.58	GeneCards inferred via : Publications (show sections)
6	LACTB	Lactamase Beta	Protein Coding	6.58	GeneCards inferred via : Publications (show sections)
7	ALB	Albumin	Protein Coding	5.9	DISEASES inferred ¹⁵
8	INS	Insulin	Protein Coding	5.82	DISEASES inferred ¹⁵
9	F2	Coagulation Factor II, Thrombin	Protein Coding	5.58	DISEASES inferred ¹⁵
10	F3	Coagulation Factor III, Tissue Factor	Protein Coding	5.16	DISEASES inferred ¹⁵
11	CD4	CD4 Molecule	Protein Coding	5.04	DISEASES inferred ¹⁵
12	SNORA59A	Small Nucleolar RNA, H/ACA Box 59A	RNA Gene	4.99	DISEASES inferred ¹⁵

Sources

Variations for Mediastinitis

Sources

Expression for Mediastinitis

Search GEO for disease gene expression data for Mediastinitis.

Sources

Pathways for Mediastinitis

Pathways related to Mediastinitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Formation of Fibrin Clot (Clotting Cascade) ⁶⁵ Show member pathways Blood Clotting Cascade ¹ Blood Coagulation Signaling Pathways ⁶⁴ Common Pathway of Fibrin Clot Formation ⁶⁵ Extrinsic Pathway of Fibrin Clot Formation ⁶⁵ Extrinsic Prothrombin Activation Pathway ⁶³ Intrinsic Pathway of Fibrin Clot Formation ⁶⁵	11.63	F5 F3 F2
2	Complement and coagulation cascades ³⁶ ¹	11.49	F5 F3 F2
3	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.35	MPO INS F2 CRP ALB
4	FOXA2 and FOXA3 transcription factor networks ¹	10.78	INS F2 ALB

Sources

GO Terms for Mediastinitis

Cellular components related to Mediastinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.7	MPO INS F5 F3 F2 CRP
2	extracellular space	GO:0005615	9.56	MPO INS F5 F3 F2 CRP
3	endoplasmic reticulum lumen	GO:0005788	9.02	INS F5 F2 CD4 ALB

Biological processes related to Mediastinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular protein metabolic process	GO:0044267	9.46	INS F5 F2 ALB
2	cellular sodium ion homeostasis	GO:0006883	9.4	ATP4A ATP12A
3	sodium ion export across plasma membrane	GO:0036376	9.37	ATP4A ATP12A
4	cellular potassium ion homeostasis	GO:0030007	9.32	ATP4A ATP12A
5	establishment or maintenance of transmembrane electrochemical gradient	GO:0010248	9.26	ATP4A ATP12A
6	hemostasis	GO:0007599	9.13	F5 F3 F2
7	acute-phase response	GO:0006953	8.8	INS F2 CRP

Molecular functions related to Mediastinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	sodium:potassium-exchanging ATPase activity	GO:0005391	9.16	ATP4A ATP12A
2	potassium-transporting ATPase activity	GO:0008556	8.96	ATP4A ATP12A
3	potassium:proton exchanging ATPase activity	GO:0008900	8.62	ATP4A ATP12A

Sources

Sources for Mediastinitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia