Aliases & Classifications for Mediastinitis

MalaCards integrated aliases for Mediastinitis:

Name: Mediastinitis 12 44 15 70

External Ids:

Disease Ontology 12 DOID:819
ICD9CM 34 519.2
MeSH 44 D008480
NCIt 50 C26827
SNOMED-CT 67 47597000
ICD10 32 J98.51
UMLS 70 C0025064

Summaries for Mediastinitis

Disease Ontology : 12 A connective tissue disease characterized by inflammation located in the mediastinum, which extends from the diaphragm to the thoracic inlet and between the pleural cavities.

MalaCards based summary : Mediastinitis is related to epiglottitis and hemopericardium, and has symptoms including chest pain and signs and symptoms. An important gene associated with Mediastinitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Vitamin D and Alfacalcidol have been mentioned in the context of this disorder. Affiliated tissues include mediastinum, lymph node and lung, and related phenotypes are cardiovascular system and digestive/alimentary

Wikipedia : 73 Mediastinitis is inflammation of the tissues in the mid-chest, or mediastinum. It can be either acute or... more...

Related Diseases for Mediastinitis

Diseases related to Mediastinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 753)
# Related Disease Score Top Affiliating Genes
1 epiglottitis 30.5 LACTB CRP
2 hemopericardium 30.3 F3 F2 CRP
3 pleural empyema 30.2 F2 CRP CD4 ALB
4 constrictive pericarditis 30.2 CRP ALB
5 pharyngitis 30.1 LACTB CRP CD4
6 endocarditis 30.1 LACTB F2 CRP ALB
7 laryngitis 30.1 CRP ATP4A ATP12A
8 pulmonary hypertension 30.0 F3 F2 CRP ALB
9 acute pancreatitis 30.0 MPO INS CRP
10 adult respiratory distress syndrome 30.0 MPO F5 F2
11 peritonitis 30.0 MPO F2 CRP ALB
12 lemierre's syndrome 29.9 F3 F2 CRP
13 esophageal tuberculosis 29.9 ATP4A ATP12A
14 pneumonia 29.9 MPO LACTB CRP ALB
15 intermediate coronary syndrome 29.9 INS F3 CRP
16 cardiac tamponade 29.9 F3 F2 CRP ALB
17 heart aneurysm 29.9 CRP ALB
18 mitral valve stenosis 29.8 F3 F2 CRP
19 tracheomalacia 29.8 ATP4A ATP12A
20 pelvic inflammatory disease 29.8 MPO LACTB CRP
21 gastroesophageal reflux 29.8 MPO ATP4A ATP12A
22 angina pectoris 29.8 INS F3 CRP
23 bronchitis 29.8 MPO LACTB CRP ALB
24 disseminated intravascular coagulation 29.8 F5 F3 F2 CRP
25 meningitis 29.7 LACTB CRP ALB
26 disease by infectious agent 29.7 LACTB CRP CD4 ALB
27 gastroenteritis 29.7 LACTB CRP ALB
28 peptic esophagitis 29.7 ATP4A ATP12A ALB
29 chickenpox 29.7 CRP CD4 ALB
30 polyneuropathy 29.6 INS CRP ALB
31 pyomyositis 29.6 CRP CD4
32 atrial heart septal defect 29.6 F3 F2 CRP ALB
33 pyuria 29.6 F2 CRP ALB
34 sclerosing cholangitis 29.6 MPO F2 ALB
35 lymph node tuberculosis 29.6 CRP CD4
36 parotitis 29.5 CRP CD4 ALB
37 facial paralysis 29.5 CRP CD4 ALB
38 otitis media 29.5 MPO LACTB CRP ALB
39 cervical adenitis 29.5 CRP CD4
40 bartonellosis 29.5 CRP CD4
41 suppurative thyroiditis 29.5 INS CRP CD4
42 mucormycosis 29.5 INS CRP CD4 ALB
43 acquired immunodeficiency syndrome 29.4 CRP CD4 ALB
44 diverticulitis 29.4 CRP ATP4A ATP12A ALB
45 nocardiosis 29.4 LACTB CRP CD4
46 purpura 29.4 F3 F2 CRP
47 bone inflammation disease 29.4 INS CRP CD4 ALB
48 pulmonary disease, chronic obstructive 29.4 MPO INS CRP CD4 ALB
49 congestive heart failure 29.4 INS CRP ALB
50 lung abscess 29.3 LACTB CRP CD4 ALB

Comorbidity relations with Mediastinitis via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease
Intermediate Coronary Syndrome Respiratory Failure

Graphical network of the top 20 diseases related to Mediastinitis:



Diseases related to Mediastinitis

Symptoms & Phenotypes for Mediastinitis

UMLS symptoms related to Mediastinitis:


chest pain; signs and symptoms

MGI Mouse Phenotypes related to Mediastinitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 ALB CRP F2 F3 F5 INS
2 digestive/alimentary MP:0005381 9.43 ALB ATP12A ATP4A CD4 F2 INS
3 homeostasis/metabolism MP:0005376 9.36 ALB ATP12A ATP4A CD4 CRP F2

Drugs & Therapeutics for Mediastinitis

Drugs for Mediastinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 106)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
2
Alfacalcidol Approved, Nutraceutical Phase 4 41294-56-8 5282181
3 Hydroxycholecalciferols Phase 4
4 Nutrients Phase 4
5 Trace Elements Phase 4
6 Micronutrients Phase 4
7 Vitamins Phase 4
8 Calciferol Phase 4
9
Oxaliplatin Approved, Investigational Phase 2, Phase 3 61825-94-3 5310940 9887054 43805 6857599
10
Tranexamic Acid Approved Phase 3 1197-18-8 5526
11
Dacarbazine Approved, Investigational Phase 2, Phase 3 4342-03-4 5351166 2942
12
Vinblastine Approved Phase 2, Phase 3 865-21-4 241903 13342
13
Nedaplatin Approved, Investigational Phase 3 95734-82-0
14
Sargramostim Approved, Investigational Phase 3 123774-72-1, 83869-56-1
15
Lenograstim Approved, Investigational Phase 3 135968-09-1
16
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
17
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
18
nivolumab Approved Phase 3 946414-94-4
19
Fluorouracil Approved Phase 3 51-21-8 3385
20
Cortisone Experimental Phase 3 53-06-5 222786
21 Pharmaceutical Solutions Phase 3
22 Antifibrinolytic Agents Phase 3
23 Hemostatics Phase 3
24 Coagulants Phase 3
25 Fibrin Tissue Adhesive Phase 3
26 Immunoglobulins, Intravenous Phase 3
27 Adjuvants, Immunologic Phase 3
28 Hydrocortisone-17-butyrate Phase 3
29 Hydrocortisone hemisuccinate Phase 3
30 Hydrocortisone 17-butyrate 21-propionate Phase 3
31 Liver Extracts Phase 3
32 Vaccines Phase 2, Phase 3
33
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
34
Decitabine Approved, Investigational Phase 1, Phase 2 2353-33-5 451668
35
Dexlansoprazole Approved, Investigational Phase 2 138530-94-6, 103577-45-3 9578005
36
Omeprazole Approved, Investigational, Vet_approved Phase 2 73590-58-6 4594
37
Lansoprazole Approved, Investigational Phase 2 103577-45-3 3883
38
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
39
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
40
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
41
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
42
Teniposide Approved Phase 2 29767-20-2 34698
43
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
44
Vindesine Approved, Investigational Phase 2 59917-39-4, 53643-48-4 40839
45
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
46
Zanubrutinib Approved, Investigational Phase 2 1691249-45-2
47
Pembrolizumab Approved Phase 2 1374853-91-4
48
Durvalumab Approved, Investigational Phase 2 1428935-60-7
49
Raltitrexed Approved, Investigational Phase 1, Phase 2 112887-68-0 104758
50
Fludarabine Approved Phase 1, Phase 2 21679-14-1, 75607-67-9 30751

Interventional clinical trials:

(show top 50) (show all 192)
# Name Status NCT ID Phase Drugs
1 Atrial Fibrillation and Pericardial Drainage: Incidence of Postoperative Atrial Fibrillation According to the Type of Mediastinal Drainage Catheters Unknown status NCT02808897 Phase 4
2 Short Term Effect of Vitamin D Supplementation on the Clinical Outcomes in Patients Undergoing Valve Replacement Surgery Completed NCT04085770 Phase 4 Alfacalcidol 1 MCG Oral Capsule
3 A Randomized, Controlled, Phase 4 Study of Sternal Plating (Rapid Sternal Closure System, KLS Martin L.P.) in Cardiac Surgical Subjects at Higher Risk for Sternal Wound Complications. Completed NCT00638014 Phase 4
4 Conventional Versus Ultrasound-guided Transbronchial Needle Aspiration, Using Rapid On-site Cytological Evaluation, for the Diagnosis of Hilar/Mediastinal Enlarged Lymph Nodes: a Randomized Controlled Trial. Completed NCT01658280 Phase 4
5 123-I mIBG (AdreView) Heart-to-Mediastinal (H/M) Ratio and SPECT Imaging Completed NCT01868841 Phase 4 AdreView
6 Efficacy and Safety Study of the Combined Modality Therapy in Patients With Potentially Resectable, Locally Advanced Adenocarcinoma of the Esophago-gastric Junction With Preoperative Chemo- and Chemoradiation Followed by Surgical Resection Unknown status NCT01523015 Phase 2, Phase 3
7 Randomized Control Study on Surgical Treatment for Middle and Lower Thoracic Esophageal Cancer Patients Without Upper Mediastinal Lymph Node Metastasis Through Left Versus Right Transthoracic Approach Unknown status NCT02448979 Phase 3
8 Endosonography (EUS and EBUS) vs Conventional Bronchoscopy for the Diagnosis of Sarcoidosis: a Randomized Trial Completed NCT00872612 Phase 3
9 Topical Application of Tranexamic Acid to Reduce Post-operative Bleeding in Coronary Artery Bypass Surgery Completed NCT01519245 Phase 3 Tranexamic Acid;normal saline
10 A Randomized Controlled Trial of Endobronchial or Endoscopic Ultrasound as a First Test in the Diagnosis and Staging of Lung Cancer Completed NCT00652769 Phase 3
11 A Randomized Phase III Study of Sequential High-Dose Cisplatinum/Etoposide/Ifosfamide Plus Stem Cell Support Versus BEP in Patients With Poor Prognosis Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
12 Early Salvage With High Dose Chemotherapy and Stem Cell Transplantation in Advanced Stage Hodgkin's Lymphoma Patients With Positive PET After Two Courses of ABVD (PET-2 Positive) and Comparison of RT Versus no RT in PET-2 Negative Patients Completed NCT00784537 Phase 2, Phase 3 ABVD;ABVD and Radiotherapy
13 Randomized Trial of Mediastinal Lymph Node Sampling Versus Complete Lymphadenectomy During Pulmonary Resection in the Patient With N0 and N1 (Less Than Hilar) Non-Small Cell Carcinoma Completed NCT00003831 Phase 3
14 Improving Preoperative Lung Cancer Staging Through the Canada Lymph Node Project: A Pan-Canadian Multicentered Crossover Trial Recruiting NCT04342377 Phase 3
15 Postoperative Pain and Quality of Life for Patients Undergoing Mediastinal Tumor Resection by Subxiphoid and Intercostal VATS:A Randomized Controlled Trial Recruiting NCT03521986 Phase 3
16 A Multicenter Prospective Randomized Controlled Study of Porcine Fibrin Sealant in Preventing Cervical Anastomotic Leakage for Esophageal or Junctional Carcinoma. (PLACE030) Recruiting NCT03847857 Phase 3
17 OMEGA, A Randomized Trial of Local Ablative Therapy Vs. Conventional Treatment in Oligometastatic NSCLC Recruiting NCT03827577 Phase 3 Standard medical therapy
18 A Phase III Clinical Trial of Docetaxel Plus Cisplatin Versus Vinorelbine Plus Cisplatin in Neoadjuvant Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma Recruiting NCT02465736 Phase 3 Docetaxel;Cisplatin;Vinorelbine;Cisplatin
19 A Prospective Clinical Trial of Improving the Treatment of Thoracic Esophageal Cancer Active, not recruiting NCT01137123 Phase 3 adjuvant chemotherapy
20 Preoperative Chemoradiotherapy vs. Chemotherapy Alone in Non-small Cell Lung Cancer (NSCLC) Patients With Mediastinal Lymph Node Metastases (Stage IIIA, N2): A Randomized Prospective Phase III Trial Active, not recruiting NCT00030771 Phase 3 Chemotherapy
21 Phase III Study Comparing Post-Operative Conformal Radiotherapy to No Post-Operative Radiotherapy in Patients With Completely Resected Non-Small Cell Lung Cancer and Mediastinal N2 Involvement [Lung ART] Active, not recruiting NCT00410683 Phase 3
22 A Randomized Phase 3 Trial of Nivolumab (NSC# 748726) in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma Not yet recruiting NCT04759586 Phase 3 Cyclophosphamide;Doxorubicin Hydrochloride;Etoposide Phosphate;Prednisolone;Prednisone;Vincristine Sulfate
23 Systemic Therapy With or Without Local Radiotherapy for Extracranial Oligometastatic Breast Cancer Not yet recruiting NCT04646564 Phase 3 standard of care
24 Adjuvant Radiotherapy for T3N0M0 Esophageal Squamous Cell Carcinoma With Positive Circumstantial Resection Margin(a Randomized Controlled Trial) Not yet recruiting NCT03273647 Phase 3
25 A Randomized, Multicenter, Double-Blind, Group-Sequential Study to Evaluate the Efficacy, Immunogenicity, and Safety of a Single Dose of Merck 0657nI Staphylococcus Aureus Vaccine (V710) in Adult Patients Scheduled for Cardiothoracic Surgery Terminated NCT00518687 Phase 2, Phase 3
26 Possibilities for Improvement of an Outcome of the Treatment in Squamous Cell Carcinoma of the Thoracic Esophagus - a Multicenter Randomized Clinical Phase III Trial. Terminated NCT00559351 Phase 3 neoadjuvant chemotherapy (cisplatin, 5-fluorouracil)
27 Combined Chemotherapy and PD-1 Antibody(SHR-1210) With or Without Low-dose Decitabine Priming for Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma (rrPMBCL):Two Stage, Phase I/II Trail Unknown status NCT03346642 Phase 1, Phase 2 Decitabine;GVD chemotherapy;SHR-1210
28 Phase II Study of Extensive Clinical Target Volumes in Postoperative Radiotherapy for Esophageal Unknown status NCT02384811 Phase 2
29 A Study of Prophylactic Oral Steroids for Fatigue and Malaise Due to Regorafenib Treatment for Unresectable Metastatic Colorectal Cancer: a Randomized, Placebo-controlled, Double-blind Phase 2 Clinical Study (KSCC1402/HGCSG1402) Unknown status NCT02288078 Phase 2 Dexamethasone;Regorafenib;Placebo;Proton pump inhibitor
30 Preoperative Chemoradiotherapy vs. Chemotherapy Alone in Nonsmall Cell Lung Cancer (NSCLC) Patients With Mediastinal Lymph Node Metastases (Stage IIIA, N2): A Randomized Prospective Phase II Trial Unknown status NCT01187290 Phase 2
31 A Phase II Study Of Preoperative Celecoxib/Paclitaxel/Carboplatin For Squamous Cell And Adenocarcinoma Of The Esophagus Completed NCT00066716 Phase 2 carboplatin;celecoxib;paclitaxel
32 A Phase II Study of Pembrolizumab (MK-3475) in Subjects With Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma (rrPMBCL) or Relapsed or Refractory Richter Syndrome (rrRS) Completed NCT02576990 Phase 2
33 A Phase I/II Study Of Brentuximab Vedotin In Combination With Multi-Agent Chemotherapy As Front-Line Treatment In Patients With CD30 Positive Primary Mediastinal Large B-Cell, Diffuse Large B-Cell, And Grey Zone Lymphomas Completed NCT01994850 Phase 1, Phase 2 brentuximab vedotin
34 A Phase II Study of SGN-35 (Brentuximab Vedotin) of Patients With Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma (PMLBCL) Completed NCT02423291 Phase 2 Brentuximab Vedotin
35 Prospective Controlled Trial of Mediastinoscopy Compared With Endobronchial Ultrasound Guided Transbronchial Needle Aspiration for Assessment of the Mediastinum in Lung Cancer. Completed NCT00372203 Phase 2
36 A Pilot Study With Cetuximab and Radiation Therapy for Patients With Surgically Resectable Esophageal and GE Junction Carcinomas: Hoosier Oncology Group Study (GI05-92) Completed NCT00319735 Phase 2
37 Multicentre Study to Optimize Therapy of Burkitt's Leukemia (B-ALL) and Non-Hodgkin Lymphoma Completed NCT01290120 Phase 2 Chemotherapy-Rituximab combination
38 Cisplatin-Docetaxel Induction Plus Concurrent 3-D Conformal Radiotherapy and Weekly Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer Patients: A Phase II Trial Completed NCT03371550 Phase 2 Docetaxel;Cisplatin
39 Preoperative Chemotherapy in Non-Small Cell Lung Cancer (NSCLC) Patients With Mediastinal Lymph Node Metastases (Stage IIIA, N2) Completed NCT00003231 Phase 2 cisplatin;docetaxel
40 Diagnostic Utility of Endobronchial Ultrasound Guided Mediastinal Lymph Node Sampling in Clinical Stage I and II Non Small Cell Lung Cancer Completed NCT00832715 Phase 1, Phase 2
41 Pilot Study of Ruxolitinib in Relapsed or Refractory Hodgkin Lymphoma and Primary Mediastinal Large B-cell Lymphoma Completed NCT01965119 Phase 2 Ruxolitinib
42 A Phase II Study on the Safety and Efficacy of Zanubrutinib Combined With Tislelizumab in the Treatment of Relapsed/Refractory Primary Mediastinal Large B-cell Lymphoma and Epstein-Barr Virus-positive Diffuse Large B-cell Lymphoma Recruiting NCT04705129 Phase 2 Zanubrutinib;Tislelizumab
43 Phase II Study of Pembrolizumab and Fractionated External Beam Radiotherapy in Patients With Relapsed and Refractory Non-Hodgkin Lymphoma Recruiting NCT03210662 Phase 2
44 LCI-LUN-NSC-SBRT-001: Phase II Prospective Trial of Primary Lung Tumor Stereotactic Body Radiation Therapy Followed by Concurrent Mediastinal Chemoradiation for Locally-Advanced Non-Small Cell Lung Cancer Recruiting NCT03141359 Phase 2 Carboplatin;Paclitaxel;cis Platinum;Etoposide;Durvalumab
45 A Feasibility Study Evaluating Neoadjuvant Hemithoracic Intensity Modulated Radiation Therapy for Surgically Resectable Malignant Pleural Mesothelioma Recruiting NCT00797719 Phase 1, Phase 2
46 Phase I/II Study of Anti-CD19 Chimeric Antigen Receptor-Expressing T Cells in Pediatric Patients Affected by Relapsed/Refractory CD19+ Acute Lymphoblastic Leukemia and Diffuse Large B Cell Lymphoma (DLBCL) or Primary Mediastinal B Cell Lymphoma (PML) Recruiting NCT04787263 Phase 1, Phase 2
47 Comparison of Safety and Efficacy Among "3-Hole" Subxiphorid Approach, Trans Sternal Approach and VATS in Surgical Treatment of Anterior Mediastinal Tumor Recruiting NCT02317224 Phase 2
48 Phase 2 Study of Copanlisib in Combination With Nivolumab in Subjects With Relapsed/Refractory Diffuse Large B-Cell Lymphoma and Primary Mediastinal Large B-Cell Lymphoma Recruiting NCT03484819 Phase 2 Copanlisib Hydrochloride
49 An Assessment of the Safety and Feasibility of Administering T-Cells Expressing an Anti-CD19 Chimeric Antigen Receptor to Patients With B-Cell Lymphoma Active, not recruiting NCT00924326 Phase 1, Phase 2 Fludarabine;Cyclophosphamide;Aldesleukin;Fludarabine;Cyclophosphamide
50 Intergroup Trial for Children or Adolescents With B-Cell NHL or B-AL: Evaluation of Rituximab Efficacy and Safety in High Risk Patients - Phase II Trial of DA-EPOCH-Rituximab in PMLBL Active, not recruiting NCT01516567 Phase 2 Etoposide, Doxorubicin, Vincristine, Cyclophosphamide, Rituximab

Search NIH Clinical Center for Mediastinitis

Cochrane evidence based reviews: mediastinitis

Genetic Tests for Mediastinitis

Anatomical Context for Mediastinitis

The Foundational Model of Anatomy Ontology organs/tissues related to Mediastinitis:

19
Mediastinum

MalaCards organs/tissues related to Mediastinitis:

40
Lymph Node, Lung, Heart, Skin, T Cells, Pancreas, Trachea

Publications for Mediastinitis

Articles related to Mediastinitis:

(show top 50) (show all 4051)
# Title Authors PMID Year
1
Complete lung collapse as a rare complication of sarcoidosis-associated mediastinal lymphadenopathy. 61
33732471 2021
2
Fibrosing Mediastinitis Associated With Tuberculosis in Children. 61
33710984 2021
3
A rare case of primary angiosarcoma of the anterior mediastinum. 61
33222090 2021
4
Delayed onset of mediastinitis with tracheomediastinal fistula following endobronchial ultrasound-guided transbronchial needle aspiration; A case report. 61
33605045 2021
5
[Diagnosis and treatment of 12 patients with deep neck infection and inferior mediastinal infection]. 61
33794630 2021
6
Circumferential esophageal perforation resulting in tension hydropneumothorax in a patient with septic shock. 61
33691378 2021
7
Finding the bubble: atypical and unusual extrapulmonary air in the chest. 61
33678458 2021
8
Retropharyngeal Abscess. Clinical Review of Twenty-five Years. 61
32487430 2021
9
A case of cervical fasciitis complicated by mediastinitis and pre-peritoneal abscess: the role of video-assisted thoracoscopic surgery. 61
33642717 2021
10
Tonsillitis, tonsillectomy, and deep neck space infections in England: the case for a new guideline for surgical and non-surgical management. 61
33645267 2021
11
Streptococcus anginosus group infection as a predictor for the progression of descending necrotizing mediastinitis. 61
33752421 2021
12
Evaluation of Outcomes Following Pulmonary Artery Stenting in Fibrosing Mediastinitis. 61
33205295 2021
13
Central venoarterial extracorporeal life support in pediatric refractory septic shock: a single center experience. 61
33719730 2021
14
Recent developments in controlling sternal wound infection after cardiac surgery and measures to enhance sternal healing. 61
33174619 2021
15
Monitoring the Impact of Aggressive Glycemic Intervention during Critical Care after Cardiac Surgery with a Glycemic Expert System for Nurse-Implemented Euglycemia: The MAGIC GENIE Project. 61
33650454 2021
16
Identification of risk factors for mortality and delayed oral dietary intake in patients with open drainage due to deep neck infections: A nationwide study using a Japanese inpatient database. 61
33650237 2021
17
CD4+CTLs in Fibrosing Mediastinitis Linked to Histoplasma capsulatum. 61
33328214 2021
18
Successful Endovascular Repair of an Aortobronchial Fistula due to Takayasu Arteritis. 61
32949744 2021
19
Development of a fully automated surgical site infection detection algorithm for use in cardiac and orthopedic surgery research. 61
33618788 2021
20
Is the Obesity Paradox in Cardiac Surgery Really a Myth? Effect of Body Mass Index on Early and Late Clinical Outcomes. 61
32423731 2021
21
A new classification of descending necrotizing mediastinitis and surgical strategies. 61
33708983 2021
22
Therapeutic drug monitoring of flucytosine in a cardiac transplant patient receiving continuous veno-venous hemofiltration and intermittent hemodialysis: A case report. 61
33527677 2021
23
Ruptured mediastinal mature teratoma causing severe mediastinitis: report of a surgically resected case and a literature review. 61
33591407 2021
24
Outcomes of primary sternal closure for postoperative mediastinitis in children. 61
33576375 2021
25
Treatment and Chest Reconstruction for Mediastinitis Following Sternotomy for Cardiac Surgery at the Heart Institute of the University of São Paulo Medical School. 61
33577255 2021
26
Mediastinitis Secondary to Peripherally Inserted Central Catheter Migration and Perforation after Minor Trauma: A Case Report. 61
33560956 2021
27
Ascending Necrotizing Mediastinitis. An Exceptional Case. 61
33714658 2021
28
[Descending Necrotising Mediastinitis: the Choice of Drainage]. 61
33535266 2021
29
A date pit induced aorto-oesophageal fistula: a case report and concise literature review. 61
33614050 2021
30
Prevention of Sternal Wound Infections in Women Using an External Sternum Fixation Corset. 61
32611929 2021
31
Endoscopic recanalization of complete esophageal obstruction. 61
33523266 2021
32
Treatment of Pediatric Sternotomy Wound Complications: A Minimally Invasive Approach. 61
33540426 2021
33
Relationship between adverse events associated with lenvatinib treatment for thyroid cancer and patient prognosis. 61
33414909 2021
34
Is vacuum-assisted closure therapy feasible for children with deep sternal wound infection after cardiac surgery? The pooling results from current literature. 61
33569832 2021
35
Accidental breakage of needle tip during endobronchial ultrasound-guided transbronchial needle aspiration: A case report and review of literature. 61
33402643 2021
36
Case Report: 18F-FDG PET-CT for Diagnosing Prosthetic Device-Related Infection in an Infant With CHD. 61
33763393 2021
37
Eradication of Staphylococcus aureus post-sternotomy mediastinitis following the implementation of universal pre-operative nasal decontamination with mupirocin: an interrupted time-series analysis. 61
33513221 2021
38
Ptosis and Miosis Associated with Fibrosing Mediastinitis. 61
33431787 2021
39
Successful management of anastomotic leakage with endoscopic fibrin glue injection after primary repair of pure oesophageal atresia. 61
33509880 2021
40
Focal Mediastinitis and Pulmonary Arterial Thrombosis after EBUS-TBNA. 61
32798007 2021
41
[Treatment of postoperative anterior mediastinitis, sternal osteomyelitis in a patient with a novel coronavirus infection]. 61
33759469 2021
42
Surgical treatment of mediastinitis: The vertical bolstered Donati stitch. 61
33577144 2021
43
Staphylococcus aureus mediastinitis due to subclavian vein perforation and catheter-related-infection. 61
33473350 2021
44
Successful treatment of left ventricular patch infection by latissimus dorsi muscle flap covering without patch removal. 61
32613497 2021
45
Immune reconstitution inflammatory syndrome in Mycobacterium chimaera mediastinitis: When clinical judgment trumps imaging. 61
33707377 2021
46
Effects of intravenous and transdermal photobiomodulation on the postoperative complications of coronary artery bypass grafting surgery: a randomized, controlled clinical trial. 61
33398614 2021
47
Clinical investigation of nosocomial infections in adult patients after cardiac surgery. 61
33530207 2021
48
Severe parapharyngeal abscess that developed significant complications: management during the COVID-19 pandemic. 61
33370968 2020
49
Initial clinical experience with minimally invasive surgical aortic valve replacement. 61
33302611 2020
50
Kazachstania slooffiae: An unexpected journey to a human pleural sample. 61
33422936 2020

Variations for Mediastinitis

Expression for Mediastinitis

Search GEO for disease gene expression data for Mediastinitis.

Pathways for Mediastinitis

Pathways related to Mediastinitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.63 F5 F3 F2
2 11.49 F5 F3 F2
3
Show member pathways
11.35 MPO INS F2 CRP ALB
4 10.78 INS F2 ALB

GO Terms for Mediastinitis

Cellular components related to Mediastinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 MPO INS F5 F3 F2 CRP
2 extracellular space GO:0005615 9.56 MPO INS F5 F3 F2 CRP
3 endoplasmic reticulum lumen GO:0005788 9.02 INS F5 F2 CD4 ALB

Biological processes related to Mediastinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.46 INS F5 F2 ALB
2 cellular sodium ion homeostasis GO:0006883 9.4 ATP4A ATP12A
3 sodium ion export across plasma membrane GO:0036376 9.37 ATP4A ATP12A
4 cellular potassium ion homeostasis GO:0030007 9.32 ATP4A ATP12A
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.26 ATP4A ATP12A
6 hemostasis GO:0007599 9.13 F5 F3 F2
7 acute-phase response GO:0006953 8.8 INS F2 CRP

Molecular functions related to Mediastinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Mediastinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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