Aliases & Classifications for Mediastinitis

MalaCards integrated aliases for Mediastinitis:

Name: Mediastinitis 12 44 15 73

External Ids:

Disease Ontology 12 DOID:819
ICD10 33 J98.51
ICD9CM 35 519.2
MeSH 44 D008480
NCIt 50 C26827
SNOMED-CT 68 47597000
UMLS 73 C0025064

Summaries for Mediastinitis

Disease Ontology : 12 A connective tissue disease characterized by inflammation located in the mediastinum, which extends from the diaphragm to the thoracic inlet and between the pleural cavities.

MalaCards based summary : Mediastinitis is related to lemierre's syndrome and pulmonary embolism, and has symptoms including chest pain and signs and symptoms. An important gene associated with Mediastinitis is MPO (Myeloperoxidase). The drugs Ticlopidine and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and lung, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Mediastinitis is inflammation of the tissues in the mid-chest, or mediastinum. It can be either acute... more...

Related Diseases for Mediastinitis

Diseases related to Mediastinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 720)
# Related Disease Score Top Affiliating Genes
1 lemierre's syndrome 29.9 CRP DNM1
2 pulmonary embolism 29.9 CRP F5
3 pleurisy 29.6 CRP MPO
4 aortic valve disease 2 29.4 CRP NKX2-6
5 peritonitis 29.4 CRP MPO
6 diaphragmatic eventration 29.4 NKX2-6 TEF
7 bronchitis 29.3 CRP MPO
8 aortitis 29.2 CRP MPO RERE
9 patent foramen ovale 29.1 F5 NKX2-6
10 fibrosing mediastinitis 12.6
11 primary mediastinal large b-cell lymphoma 12.3
12 primary mediastinal b-cell lymphoma 12.3
13 mediastinal cancer 12.2
14 malignant mediastinal neurogenic neoplasm 12.2
15 mediastinal lipomatosis 12.2
16 mediastinal gray zone lymphoma 12.2
17 mediastinal malignant lymphoma 12.2
18 mediastinal endodermal sinus tumors 12.1
19 benign mediastinal neurilemmoma 12.1
20 mediastinal granular cell myoblastoma 12.1
21 mediastinal neurilemmoma 12.1
22 mediastinal osteogenic sarcoma 12.1
23 childhood mediastinal neurogenic tumor 12.0
24 mediastinal melanocytic neurilemmoma 12.0
25 benign mediastinal psammomatous neurilemmoma 12.0
26 mediastinal mesenchymal tumor 11.9
27 igg4-related disease 11.3
28 fibrosclerosis, multifocal 11.3
29 lipomatosis, multiple symmetric 11.0
30 pagod syndrome 11.0
31 anemia, congenital dyserythropoietic, type ii 11.0
32 carney triad 11.0
33 mediastinum neuroblastoma 11.0
34 mediastinum sarcoma 11.0
35 malignant melanocytic peripheral nerve sheath tumor of mediastinum 11.0
36 lymphoma 10.7
37 b-cell lymphomas 10.7
38 teratoma 10.5
39 adenoma 10.5
40 parathyroid adenoma 10.5
41 germ cells tumors 10.4
42 lung cancer 10.4
43 sarcoma 10.4
44 goiter 10.4
45 seminoma 10.4
46 bronchogenic cyst 10.4
47 liposarcoma 10.3
48 small cell cancer of the lung 10.3
49 lymphangioma 10.3
50 lymphadenitis 10.3

Comorbidity relations with Mediastinitis via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease
Intermediate Coronary Syndrome Ischemic Heart Disease
Respiratory Failure

Graphical network of the top 20 diseases related to Mediastinitis:



Diseases related to Mediastinitis

Symptoms & Phenotypes for Mediastinitis

UMLS symptoms related to Mediastinitis:


chest pain, signs and symptoms

MGI Mouse Phenotypes related to Mediastinitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 CRP DNM1 F5 MPO NKX2-6 RERE
2 homeostasis/metabolism MP:0005376 9.5 CRP DNM1 F5 MPO NKX2-6 RPS6KB2
3 mortality/aging MP:0010768 9.23 DNM1 F5 MAPKAPK3 MPO NKX2-6 RERE

Drugs & Therapeutics for Mediastinitis

Drugs for Mediastinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 107)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ticlopidine Approved Phase 4 55142-85-3 5472
2
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
3
Povidone Approved Phase 4 9003-39-8
4
Iodine Approved, Investigational Phase 4 7553-56-2 807
5
Ethanol Approved Phase 4 64-17-5 702
6
Povidone-iodine Approved Phase 4 25655-41-8
7
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
8
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
9
Desflurane Approved Phase 4 57041-67-5 42113
10
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
11
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
12 tannic acid Approved Phase 4
13
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
14 Coagulants Phase 4,Phase 3
15 Hemostatics Phase 4,Phase 3
16 Fibrinolytic Agents Phase 4,Not Applicable
17 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable
18 Purinergic P2 Receptor Antagonists Phase 4
19 Purinergic P2Y Receptor Antagonists Phase 4
20 Cytochrome P-450 Enzyme Inhibitors Phase 4
21 Platelet Aggregation Inhibitors Phase 4
22 Cytochrome P-450 CYP2C19 Inhibitors Phase 4
23 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
24 Anesthetics Phase 4,Not Applicable
25 Chlorhexidine gluconate Phase 4
26 Plasma Substitutes Phase 4
27 Micronutrients Phase 4
28 Anti-Infective Agents, Local Phase 4
29 cadexomer iodine Phase 4
30 Blood Substitutes Phase 4
31 Dermatologic Agents Phase 4
32 Trace Elements Phase 4
33 Central Nervous System Depressants Phase 4
34 Disinfectants Phase 4
35 Anesthetics, Intravenous Phase 4
36 Hypnotics and Sedatives Phase 4
37 Anesthetics, General Phase 4
38 Hypoglycemic Agents Phase 4
39 insulin Phase 4
40 Insulin, Globin Zinc Phase 4
41
Norepinephrine Approved Phase 3 51-41-2 439260
42
Mupirocin Approved, Investigational, Vet_approved Phase 3 12650-69-0 446596
43
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
44
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
45
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
46
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
47
Thrombin Approved, Investigational Phase 3
48
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
49 Vasoconstrictor Agents Phase 3
50 Vasopressins Phase 3

Interventional clinical trials:

(show top 50) (show all 58)
# Name Status NCT ID Phase Drugs
1 Improvement of Hemostasis Techniques After Median Sternotomy Unknown status NCT01134471 Phase 4
2 The Effect of Chest Tubes Using Active Clearance Technology® on the Incidence of Postoperative Atrial Fibrillation Unknown status NCT02808897 Phase 4
3 Rapid Sternal Closure System (TALON) Completed NCT00638014 Phase 4
4 Effect of Clopidogrel (Plavix) on Postoperative Bleeding in Patients Undergoing Coronary Artery Bypass Surgery. Completed NCT00724880 Phase 4 Clopidogrel;Clopidogrel;Clopidogrel
5 Randomized Trial of 2% Chlorhexidine-70% Isopropanol vs 5% Povidone Iodine-69% Ethanol for Skin Antisepsis in Reducing Surgical-site Infection After Cardiac Surgery Recruiting NCT03560193 Phase 4 2%Chlorhexidine-70%Isopropanol;5%Povidone Iodine- 69%Ethanol
6 Delirium Reduction by Volatile Anesthesia in Cardiac Surgery Recruiting NCT03729011 Phase 4 Volatile agent;Propofol
7 Tight Intra-Operative Glucose Control During Coronary Artery Bypass Surgery Terminated NCT00394303 Phase 4 Intraoperative continuous insulin infusion
8 SOLAR & ATRILAZE Atrial Fibrillation Trial Unknown status NCT00734058 Phase 3
9 Vasopressin Versus Norepinephrine for the Management of Shock After Cardiac Surgery Unknown status NCT01505231 Phase 3 Vasopressin;Norepinephrine
10 Concomitant Utilization of Radio Frequency Energy for Atrial Fibrillation (CURE-AF) Study Completed NCT00431834 Phase 3
11 Medtronic Concomitant Utilization of Radio Frequency for Atrial Fibrillation CURE-AF/Persistent Completed NCT00506493 Phase 3
12 Efficacy Study of Mupirocin on Infection After Coronary Artery Bypass Grafting Completed NCT01949935 Phase 3 Mupirocin
13 STeroids to REduce Systemic Inflammation After Neonatal Heart Surgery Recruiting NCT03229538 Phase 3 Methylprednisolone;Isotonic saline
14 Administration of Prothrombin Complex Concentrate vs. Standard Transfusion During/After Heart Transplantation Recruiting NCT03341156 Phase 3 Kcentra;Frozen Plasma Product, Human
15 Efficacy, Immunogenicity, and Safety of a Single Dose of V710 in Adult Patients Scheduled for Cardiothoracic Surgery (V710-003 AM2) Terminated NCT00518687 Phase 2, Phase 3
16 The eMESH 1 Feasibility Study Recruiting NCT01676376 Phase 1, Phase 2
17 ESI With EUS to Differentiate T3 and T4 ESCC Unknown status NCT01930630 Phase 1
18 Factors Associated With Complications of Cervical Necrotizing Fasciitis Unknown status NCT02847234
19 Delayed Primary Versus Late Secondary Wound Closure in Sternum Infections Unknown status NCT01473979 Not Applicable
20 Intra-aortic Balloon Counterpulsation in Patients Undergoing Cardiac Surgery Unknown status NCT02143544 Not Applicable
21 Endoscopic-vacuum Assisted Closure of Intrathoracic Postsurgical Leaks Unknown status NCT00876551 Not Applicable
22 Goal Direct Therapy to Prevent Acute Kidney Injury Unknown status NCT02396901 Not Applicable
23 Accuracy and Safety of Endobronchial Ultrasound (EBUS) in Suspected Non-malignant Mediastinal Lymphadenopathy Unknown status NCT02398864 Not Applicable
24 Thrombolytic Therapy Versus Surgery for Obstructive Prosthetic Valve Thrombosis Unknown status NCT02243839 Not Applicable Thrombolytic Therapy
25 Topical Vancomycin in Prevention of Methicillin-Resistant Staphylococcal Related Mediastinitis in Patients Receiving Coronary Artery Bypass Graft Completed NCT00711685 Not Applicable
26 Physiotherapy Exercises in Patients With Sternal Instability After Cardiovascular Surgery Completed NCT02513576 Not Applicable
27 Role of Cerebral Oximetry in Reducing Postoperative Morbidity Following Cardiac Surgery Completed NCT02155868 Not Applicable
28 Evaluation of Primary Plating in Sternotomy Patients for Osteosynthesis and Pain Completed NCT00819286 Not Applicable
29 Perioperative Intra-Aortic Balloon Pump (IABP) in Coronary Artery Bypass Grafting (CABG) Operations in Patients With Severely Depressed Left Ventricular Function Completed NCT00881192 Not Applicable
30 Pharmacokinetics of Cefuroxime in Cardiac Surgery With Cardiopulmonary Bypass Completed NCT01228825
31 Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2 Completed NCT02073760
32 Impact of Microparticles in Blood on Transfused Patient Outcomes Completed NCT03041974
33 Open Lung Protective Ventilation in Cardiac Surgery Completed NCT02866578 Not Applicable
34 Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery Completed NCT02068716
35 Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass Surgery Completed NCT01153360 Not Applicable liothyronine sodium;placebo
36 Glutamine to Improve Outcomes in Cardiac Surgery Completed NCT01704430 Not Applicable
37 Mediastinitis and Staphylococcus Aureus Recruiting NCT03262558
38 Creation of a Biospecimen Repository From Patients With Interstitial Lung Diseases (ILD) Recruiting NCT03478826
39 Medtronic Terminate AF Study Recruiting NCT03546374 Not Applicable
40 A Study Evaluating the Diagnostic Yield and Safety of the ProCore vs Conventional EBUS-TBNA Needle in Subjects With Suspected Sarcoidosis Recruiting NCT03656003 Not Applicable
41 Feasibility of Transcatheter Aortic Valve Replacement in Low-Risk Patients With Symptomatic, Severe Aortic Stenosis Recruiting NCT02628899 Not Applicable
42 Study of the Combined Influence of Sepsis and Mechanical Ventilation on the Human Diaphragm Recruiting NCT03371602 Not Applicable
43 Registry for the Improvement of Postoperative OutcomeS in Cardiac and Thoracic surgEry Recruiting NCT03209674
44 Dumping Syndrome After Operation of Esophageal Atresia Type III Recruiting NCT02525705 Not Applicable
45 The Goal dIrected perFusion Trial in Cardiac Surgery Recruiting NCT02250131 Not Applicable
46 Eso-Sponge Registry Recruiting NCT02662777
47 Impact of Perivascular Tissue on Endothelial Function in Coronary Artery Bypass Grafting Recruiting NCT01834846 Not Applicable
48 Quality of Life After Ministernotomy Versus Full Sternotomy Aortic Valve Replacement Recruiting NCT02726087 Not Applicable
49 Assessment of Cerebral Blood Flow Asymmetry in Cardiac Surgery Patients Undergoing Hypothermic Circulatory Arrest Recruiting NCT03215589
50 Efficacy of Intravenous In-line Filter in Patient Undergoing Cardiac Surgery Recruiting NCT03784521 Not Applicable

Search NIH Clinical Center for Mediastinitis

Cochrane evidence based reviews: mediastinitis

Genetic Tests for Mediastinitis

Anatomical Context for Mediastinitis

MalaCards organs/tissues related to Mediastinitis:

41
Heart, Bone, Lung, Skin, Thyroid, Lymph Node, B Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Mediastinitis:

19
The Mediastinum

Publications for Mediastinitis

Articles related to Mediastinitis:

(show top 50) (show all 1049)
# Title Authors Year
1
Patient with mediastinitis caused by delayed mucosal damage after peroral endoscopic myotomy. ( 29656451 )
2018
2
Deep neck infection and descending mediastinitis as lethal complications of dentoalveolar infection: two rare case reports. ( 29980234 )
2018
3
Fibrosing Mediastinitis: Uncommon Life-threatening Complication of Histoplasmosis. ( 29946500 )
2018
4
The Impact of the Medicaid Healthcare-Associated Condition Program on Mediastinitis Following Coronary Artery Bypass Graft. ( 29669607 )
2018
5
Effect of chlorhexidine skin disinfection and retrosternal gentamicin sponge on post-sternotomy mediastinitis: results from a prospective controlled registry of 2340 patients. ( 29409978 )
2018
6
Lethal fibrosing mediastinitis in a child possibly due to Mycobacterium tuberculosis. ( 29635837 )
2018
7
Fibrosing mediastinitis-related pulmonary artery and vein stenosis-limiting chemotherapy. ( 29754128 )
2018
8
Septic shock from descending necrotizing mediastinitis - combined treatment with IgM-enriched immunoglobulin preparation and direct polymyxin B hemoperfusion: a case report. ( 29499757 )
2018
9
Group C strep mediastinitis. ( 29454509 )
2018
10
Med-Score 24: A multivariable prediction model for poststernotomy mediastinitis 24A hours after admission to the intensive care unit. ( 29273422 )
2018
11
Fibrosing mediastinitis with pulmonary hypertension as a complication of pulmonary vein stenosis: A case report and review of the literature. ( 29369193 )
2018
12
Enzymatic mediastinitis as a fearsome complication of pancreatic necrosectomy. ( 29931993 )
2018
13
Endovascular Management of SVC Syndrome due to Fibrosing Mediastinitis-A Feasibility and Safety Analysis. ( 29433409 )
2018
14
Recurrent Pneumonia due to Fibrosing Mediastinitis in a Teenage Girl: A Case Report with Long-Term Follow-Up. ( 29744231 )
2018
15
SurgicelAr packing remnants mimicking mediastinitis after adult cardiac surgery. ( 29365109 )
2018
16
Taking heed of the 'danger space': acute descending necrotising mediastinitis secondary to primary odontogenic infection. ( 29848536 )
2018
17
IgG4-related fibrosing mediastinitis diagnosed with computed tomography-guided percutaneous needle biopsy: Two case reports and a review of the literature. ( 29851832 )
2018
18
Mediastinitis superinfected by Achromobacter xylosoxidans. A case report. ( 29895453 )
2018
19
A giant thoracic aortic aneurysm causing multiple fistulas and mediastinitis. ( 30336274 )
2018
20
Clinical and imaging spectrum of tuberculosis-associated fibrosing mediastinitis. ( 29356415 )
2018
21
A case of fibrosing mediastinitis complicated by pulmonary hypertension and right-sided heart failure. ( 30202958 )
2018
22
Fibrosing Mediastinitis: a Rare Cause of Unilateral Absent Lung Perfusion on a V/Q Scan. ( 30344792 )
2018
23
Pulmonary Arterial Bypass Surgery for Fibrosing Mediastinitis Causing Severe Pulmonary Hypertension. ( 30447188 )
2018
24
Exceptional association of two species of bacteria causing mediastinitis: Haemophilus influenzae (H. influenzae) and Aggregatibacter aphrophilus (A. aphrophilus). ( 30115033 )
2018
25
Poststernotomy mediastinitis: Early risk factors identified but hard to modify. ( 29113644 )
2018
26
Complete excision of acute necrotic regression of thymoma mimicking an infected mediastinal cyst with mediastinitis using video-assisted thoracoscopic technique. ( 29997995 )
2018
27
Fulminant descending mediastinitis secondary to infectious mononucleosis. ( 30093999 )
2018
28
Descending necrotizing mediastinitis after sequestrectomy in a patient with bisphosphonate-induced osteonecrosis of the jaw: A case report. ( 30101025 )
2018
29
Senile Lemierre syndrome complicated with descending necrotizing mediastinitis: A case report. ( 30170383 )
2018
30
Spontaneous mediastinitis with multiple esophageal abscess in the esophagus. ( 30225188 )
2018
31
Acute descending necrotizing mediastinitis: four years of experience at a hospital center in Madagascar. ( 30270835 )
2018
32
Vacuum-Assisted Closure for Mediastinitis in Pediatric Cardiac Surgery: A Single-Center Experience. ( 30281163 )
2018
33
Usefulness of a temporary endovascular left ventricular assist system as a bridge to facilitate treatment of mediastinitis associated with a permanent device. ( 30396846 )
2018
34
Effective Combination of Different Surgical Strategies for Deep Sternal Wound Infection and Mediastinitis. ( 30404980 )
2018
35
Descending necrotizing mediastinitis in a healthy young adult. ( 30425498 )
2018
36
A Fatal Mediastinitis Due to a Neck Trauma from an Undeclared Assault. ( 30444943 )
2018
37
Successful Treatment of a Late Diagnosed Esophageal Perforation with Mediastinitis and Pericardial Abscess. ( 30501839 )
2018
38
The risk of mediastinitis and deep sternal wound infections with single and bilateral, pedicled and skeletonized internal thoracic arteries. ( 30505751 )
2018
39
Risk factors for delayed oral dietary intake in patients with deep neck infections including descending necrotizing mediastinitis. ( 28825131 )
2017
40
Mediastinitis as a complication of minimally invasive diagnostic and mediastinal staging techniques. ( 29254905 )
2017
41
European Association for Cardio-Thoracic Surgery expert consensus statement on the prevention and management of mediastinitis. ( 28077503 )
2017
42
Fatal case of descending necrotising mediastinitis. ( 28705850 )
2017
43
Unexpected Fibrosing Mediastinitis Shown on FDG PET/CT in a Patient With IgG4-Related Disease. ( 28806261 )
2017
44
Challenges in Destination LVAD Therapy, Management of Mediastinitis and Device Infection, a Case Report. ( 28784570 )
2017
45
Low antibodies titer and serological cross-reaction between Coxiella burnetii and Legionella pneumophila challenge the diagnosis of mediastinitis, an emerging Q fever clinical entity. ( 28779434 )
2017
46
Utility of PET scan in diagnosis and monitoring descending necrotizing mediastinitis complicating Lemierre's syndrome. ( 28776174 )
2017
47
Idiopathic fibrosing mediastinitis mimicking nodal metastasis from breast cancer. ( 28114793 )
2017
48
Predictors of Mediastinitis Risk after Coronary Artery Bypass Surgery: Applicability of Score in 1.322 Cases. ( 28832745 )
2017
49
Effect of polymyxin B-containing regimens on renal function for the treatment of carbapenem-resistant Enterobacteriacea mediastinitis. ( 29182906 )
2017
50
Chest Necrotizing Fasciitis with Mediastinitis. ( 28674375 )
2017

Variations for Mediastinitis

Expression for Mediastinitis

Search GEO for disease gene expression data for Mediastinitis.

Pathways for Mediastinitis

GO Terms for Mediastinitis

Sources for Mediastinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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