Mediastinitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MDS022 MIFTS: 41	Mediastinitis
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Mediastinitis

MalaCards integrated aliases for Mediastinitis:

Name: Mediastinitis ¹² ⁴⁴ ¹⁵ ⁷³

External Ids:

Disease Ontology ¹² DOID:819

ICD10 ³³ J98.51

ICD9CM ³⁵ 519.2

MeSH ⁴⁴ D008480

NCIt ⁵⁰ C26827

SNOMED-CT ⁶⁸ 47597000

UMLS ⁷³ C0025064

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Summaries for Mediastinitis

Disease Ontology : ¹² A connective tissue disease characterized by inflammation located in the mediastinum, which extends from the diaphragm to the thoracic inlet and between the pleural cavities.

MalaCards based summary : Mediastinitis is related to lemierre's syndrome and pulmonary embolism, and has symptoms including chest pain and signs and symptoms. An important gene associated with Mediastinitis is MPO (Myeloperoxidase). The drugs Ticlopidine and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and lung, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : ⁷⁶ Mediastinitis is inflammation of the tissues in the mid-chest, or mediastinum. It can be either acute... more...

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Related Diseases for Mediastinitis

Diseases related to Mediastinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 720)

#	Related Disease	Score	Top Affiliating Genes
1	lemierre's syndrome	29.9	CRP DNM1
2	pulmonary embolism	29.9	CRP F5
3	pleurisy	29.6	CRP MPO
4	aortic valve disease 2	29.4	CRP NKX2-6
5	peritonitis	29.4	CRP MPO
6	diaphragmatic eventration	29.4	NKX2-6 TEF
7	bronchitis	29.3	CRP MPO
8	aortitis	29.2	CRP MPO RERE
9	patent foramen ovale	29.1	F5 NKX2-6
10	fibrosing mediastinitis	12.6
11	primary mediastinal large b-cell lymphoma	12.3
12	primary mediastinal b-cell lymphoma	12.3
13	mediastinal cancer	12.2
14	malignant mediastinal neurogenic neoplasm	12.2
15	mediastinal lipomatosis	12.2
16	mediastinal gray zone lymphoma	12.2
17	mediastinal malignant lymphoma	12.2
18	mediastinal endodermal sinus tumors	12.1
19	benign mediastinal neurilemmoma	12.1
20	mediastinal granular cell myoblastoma	12.1
21	mediastinal neurilemmoma	12.1
22	mediastinal osteogenic sarcoma	12.1
23	childhood mediastinal neurogenic tumor	12.0
24	mediastinal melanocytic neurilemmoma	12.0
25	benign mediastinal psammomatous neurilemmoma	12.0
26	mediastinal mesenchymal tumor	11.9
27	igg4-related disease	11.3
28	fibrosclerosis, multifocal	11.3
29	lipomatosis, multiple symmetric	11.0
30	pagod syndrome	11.0
31	anemia, congenital dyserythropoietic, type ii	11.0
32	carney triad	11.0
33	mediastinum neuroblastoma	11.0
34	mediastinum sarcoma	11.0
35	malignant melanocytic peripheral nerve sheath tumor of mediastinum	11.0
36	lymphoma	10.7
37	b-cell lymphomas	10.7
38	teratoma	10.5
39	adenoma	10.5
40	parathyroid adenoma	10.5
41	germ cells tumors	10.4
42	lung cancer	10.4
43	sarcoma	10.4
44	goiter	10.4
45	seminoma	10.4
46	bronchogenic cyst	10.4
47	liposarcoma	10.3
48	small cell cancer of the lung	10.3
49	lymphangioma	10.3
50	lymphadenitis	10.3

Comorbidity relations with Mediastinitis via Phenotypic Disease Network (PDN):

Familial Atrial Fibrillation	Heart Disease
Intermediate Coronary Syndrome	Ischemic Heart Disease
Respiratory Failure

Graphical network of the top 20 diseases related to Mediastinitis:

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Symptoms & Phenotypes for Mediastinitis

UMLS symptoms related to Mediastinitis:

chest pain, signs and symptoms

MGI Mouse Phenotypes related to Mediastinitis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.76	CRP DNM1 F5 MPO NKX2-6 RERE
2	homeostasis/metabolism	MP:0005376	9.5	CRP DNM1 F5 MPO NKX2-6 RPS6KB2
3	mortality/aging	MP:0010768	9.23	DNM1 F5 MAPKAPK3 MPO NKX2-6 RERE

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Drugs & Therapeutics for Mediastinitis

Drugs for Mediastinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 107)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Ticlopidine

Approved

Phase 4

55142-85-3

5472

Clopidogrel

Approved

Phase 4

113665-84-2, 120202-66-6

60606

Povidone

Approved

Phase 4

9003-39-8

Iodine

Approved, Investigational

Phase 4

7553-56-2

807

Ethanol

Approved

Phase 4

64-17-5

702

Povidone-iodine

Approved

Phase 4

25655-41-8

Chlorhexidine

Approved, Vet_approved

Phase 4

55-56-1

2713 9552079

Propofol

Approved, Investigational, Vet_approved

Phase 4

2078-54-8

4943

Desflurane

Approved

Phase 4

57041-67-5

42113

Sevoflurane

Approved, Vet_approved

Phase 4

28523-86-6

5206

Isoflurane

Approved, Vet_approved

Phase 4

26675-46-7

3763

tannic acid

Approved

Phase 4

Benzocaine

Approved, Investigational

Phase 4

94-09-7, 1994-09-7

2337

Coagulants

Phase 4,Phase 3

Hemostatics

Phase 4,Phase 3

Fibrinolytic Agents

Phase 4,Not Applicable

Neurotransmitter Agents

Phase 4,Phase 3,Not Applicable

Purinergic P2 Receptor Antagonists

Phase 4

Purinergic P2Y Receptor Antagonists

Phase 4

Cytochrome P-450 Enzyme Inhibitors

Phase 4

Platelet Aggregation Inhibitors

Phase 4

Cytochrome P-450 CYP2C19 Inhibitors

Phase 4

Anti-Infective Agents

Phase 4,Phase 3,Not Applicable

Anesthetics

Phase 4,Not Applicable

Chlorhexidine gluconate

Phase 4

Plasma Substitutes

Phase 4

Micronutrients

Phase 4

Anti-Infective Agents, Local

Phase 4

cadexomer iodine

Phase 4

Blood Substitutes

Phase 4

Dermatologic Agents

Phase 4

Trace Elements

Phase 4

Central Nervous System Depressants

Phase 4

Disinfectants

Phase 4

Anesthetics, Intravenous

Phase 4

Hypnotics and Sedatives

Phase 4

Anesthetics, General

Phase 4

Hypoglycemic Agents

Phase 4

insulin

Phase 4

Insulin, Globin Zinc

Phase 4

Norepinephrine

Approved

Phase 3

51-41-2

439260

Mupirocin

Approved, Investigational, Vet_approved

Phase 3

12650-69-0

446596

Methylprednisolone

Approved, Vet_approved

Phase 3

83-43-2

6741

Prednisolone

Approved, Vet_approved

Phase 3

50-24-8

5755

Prednisolone phosphate

Approved, Vet_approved

Phase 3

302-25-0

Methylprednisolone hemisuccinate

Approved

Phase 3

2921-57-5

Thrombin

Approved, Investigational

Phase 3

Prednisolone hemisuccinate

Experimental

Phase 3

2920-86-7

Vasoconstrictor Agents

Phase 3

Vasopressins

Phase 3

Interventional clinical trials:

(show top 50) (show all 58)

#	Name	Status	NCT ID	Phase	Drugs
1	Improvement of Hemostasis Techniques After Median Sternotomy	Unknown status	NCT01134471	Phase 4
2	The Effect of Chest Tubes Using Active Clearance Technology® on the Incidence of Postoperative Atrial Fibrillation	Unknown status	NCT02808897	Phase 4
3	Rapid Sternal Closure System (TALON)	Completed	NCT00638014	Phase 4
4	Effect of Clopidogrel (Plavix) on Postoperative Bleeding in Patients Undergoing Coronary Artery Bypass Surgery.	Completed	NCT00724880	Phase 4	Clopidogrel;Clopidogrel;Clopidogrel
5	Randomized Trial of 2% Chlorhexidine-70% Isopropanol vs 5% Povidone Iodine-69% Ethanol for Skin Antisepsis in Reducing Surgical-site Infection After Cardiac Surgery	Recruiting	NCT03560193	Phase 4	2%Chlorhexidine-70%Isopropanol;5%Povidone Iodine- 69%Ethanol
6	Delirium Reduction by Volatile Anesthesia in Cardiac Surgery	Recruiting	NCT03729011	Phase 4	Volatile agent;Propofol
7	Tight Intra-Operative Glucose Control During Coronary Artery Bypass Surgery	Terminated	NCT00394303	Phase 4	Intraoperative continuous insulin infusion
8	SOLAR & ATRILAZE Atrial Fibrillation Trial	Unknown status	NCT00734058	Phase 3
9	Vasopressin Versus Norepinephrine for the Management of Shock After Cardiac Surgery	Unknown status	NCT01505231	Phase 3	Vasopressin;Norepinephrine
10	Concomitant Utilization of Radio Frequency Energy for Atrial Fibrillation (CURE-AF) Study	Completed	NCT00431834	Phase 3
11	Medtronic Concomitant Utilization of Radio Frequency for Atrial Fibrillation CURE-AF/Persistent	Completed	NCT00506493	Phase 3
12	Efficacy Study of Mupirocin on Infection After Coronary Artery Bypass Grafting	Completed	NCT01949935	Phase 3	Mupirocin
13	STeroids to REduce Systemic Inflammation After Neonatal Heart Surgery	Recruiting	NCT03229538	Phase 3	Methylprednisolone;Isotonic saline
14	Administration of Prothrombin Complex Concentrate vs. Standard Transfusion During/After Heart Transplantation	Recruiting	NCT03341156	Phase 3	Kcentra;Frozen Plasma Product, Human
15	Efficacy, Immunogenicity, and Safety of a Single Dose of V710 in Adult Patients Scheduled for Cardiothoracic Surgery (V710-003 AM2)	Terminated	NCT00518687	Phase 2, Phase 3
16	The eMESH 1 Feasibility Study	Recruiting	NCT01676376	Phase 1, Phase 2
17	ESI With EUS to Differentiate T3 and T4 ESCC	Unknown status	NCT01930630	Phase 1
18	Factors Associated With Complications of Cervical Necrotizing Fasciitis	Unknown status	NCT02847234
19	Delayed Primary Versus Late Secondary Wound Closure in Sternum Infections	Unknown status	NCT01473979	Not Applicable
20	Intra-aortic Balloon Counterpulsation in Patients Undergoing Cardiac Surgery	Unknown status	NCT02143544	Not Applicable
21	Endoscopic-vacuum Assisted Closure of Intrathoracic Postsurgical Leaks	Unknown status	NCT00876551	Not Applicable
22	Goal Direct Therapy to Prevent Acute Kidney Injury	Unknown status	NCT02396901	Not Applicable
23	Accuracy and Safety of Endobronchial Ultrasound (EBUS) in Suspected Non-malignant Mediastinal Lymphadenopathy	Unknown status	NCT02398864	Not Applicable
24	Thrombolytic Therapy Versus Surgery for Obstructive Prosthetic Valve Thrombosis	Unknown status	NCT02243839	Not Applicable	Thrombolytic Therapy
25	Topical Vancomycin in Prevention of Methicillin-Resistant Staphylococcal Related Mediastinitis in Patients Receiving Coronary Artery Bypass Graft	Completed	NCT00711685	Not Applicable
26	Physiotherapy Exercises in Patients With Sternal Instability After Cardiovascular Surgery	Completed	NCT02513576	Not Applicable
27	Role of Cerebral Oximetry in Reducing Postoperative Morbidity Following Cardiac Surgery	Completed	NCT02155868	Not Applicable
28	Evaluation of Primary Plating in Sternotomy Patients for Osteosynthesis and Pain	Completed	NCT00819286	Not Applicable
29	Perioperative Intra-Aortic Balloon Pump (IABP) in Coronary Artery Bypass Grafting (CABG) Operations in Patients With Severely Depressed Left Ventricular Function	Completed	NCT00881192	Not Applicable
30	Pharmacokinetics of Cefuroxime in Cardiac Surgery With Cardiopulmonary Bypass	Completed	NCT01228825
31	Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2	Completed	NCT02073760
32	Impact of Microparticles in Blood on Transfused Patient Outcomes	Completed	NCT03041974
33	Open Lung Protective Ventilation in Cardiac Surgery	Completed	NCT02866578	Not Applicable
34	Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery	Completed	NCT02068716
35	Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass Surgery	Completed	NCT01153360	Not Applicable	liothyronine sodium;placebo
36	Glutamine to Improve Outcomes in Cardiac Surgery	Completed	NCT01704430	Not Applicable
37	Mediastinitis and Staphylococcus Aureus	Recruiting	NCT03262558
38	Creation of a Biospecimen Repository From Patients With Interstitial Lung Diseases (ILD)	Recruiting	NCT03478826
39	Medtronic Terminate AF Study	Recruiting	NCT03546374	Not Applicable
40	A Study Evaluating the Diagnostic Yield and Safety of the ProCore vs Conventional EBUS-TBNA Needle in Subjects With Suspected Sarcoidosis	Recruiting	NCT03656003	Not Applicable
41	Feasibility of Transcatheter Aortic Valve Replacement in Low-Risk Patients With Symptomatic, Severe Aortic Stenosis	Recruiting	NCT02628899	Not Applicable
42	Study of the Combined Influence of Sepsis and Mechanical Ventilation on the Human Diaphragm	Recruiting	NCT03371602	Not Applicable
43	Registry for the Improvement of Postoperative OutcomeS in Cardiac and Thoracic surgEry	Recruiting	NCT03209674
44	Dumping Syndrome After Operation of Esophageal Atresia Type III	Recruiting	NCT02525705	Not Applicable
45	The Goal dIrected perFusion Trial in Cardiac Surgery	Recruiting	NCT02250131	Not Applicable
46	Eso-Sponge Registry	Recruiting	NCT02662777
47	Impact of Perivascular Tissue on Endothelial Function in Coronary Artery Bypass Grafting	Recruiting	NCT01834846	Not Applicable
48	Quality of Life After Ministernotomy Versus Full Sternotomy Aortic Valve Replacement	Recruiting	NCT02726087	Not Applicable
49	Assessment of Cerebral Blood Flow Asymmetry in Cardiac Surgery Patients Undergoing Hypothermic Circulatory Arrest	Recruiting	NCT03215589
50	Efficacy of Intravenous In-line Filter in Patient Undergoing Cardiac Surgery	Recruiting	NCT03784521	Not Applicable

Search NIH Clinical Center for Mediastinitis

Cochrane evidence based reviews: mediastinitis

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Genetic Tests for Mediastinitis

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Anatomical Context for Mediastinitis

MalaCards organs/tissues related to Mediastinitis:

⁴¹

Heart, Bone, Lung, Skin, Thyroid, Lymph Node, B Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Mediastinitis:

¹⁹

The Mediastinum

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Publications for Mediastinitis

Articles related to Mediastinitis:

(show top 50) (show all 1049)

#	Title	Authors	Year
1	Patient with mediastinitis caused by delayed mucosal damage after peroral endoscopic myotomy. ( 29656451 )	Okada H....Hasegawa S.	2018
2	Deep neck infection and descending mediastinitis as lethal complications of dentoalveolar infection: two rare case reports. ( 29980234 )	Alegbeleye B.J.	2018
3	Fibrosing Mediastinitis: Uncommon Life-threatening Complication of Histoplasmosis. ( 29946500 )	Khalid M....Youssef D.	2018
4	The Impact of the Medicaid Healthcare-Associated Condition Program on Mediastinitis Following Coronary Artery Bypass Graft. ( 29669607 )	Hsu H.E....Lee G.M.	2018
5	Effect of chlorhexidine skin disinfection and retrosternal gentamicin sponge on post-sternotomy mediastinitis: results from a prospective controlled registry of 2340 patients. ( 29409978 )	Waldow T....Matschke K.	2018
6	Lethal fibrosing mediastinitis in a child possibly due to Mycobacterium tuberculosis. ( 29635837 )	Goussard P....Janson J.	2018
7	Fibrosing mediastinitis-related pulmonary artery and vein stenosis-limiting chemotherapy. ( 29754128 )	Co M.L.F....Okwuosa T.M.	2018
8	Septic shock from descending necrotizing mediastinitis - combined treatment with IgM-enriched immunoglobulin preparation and direct polymyxin B hemoperfusion: a case report. ( 29499757 )	Pota V....Aurilio C.	2018
9	Group C strep mediastinitis. ( 29454509 )	Kotora J.G....Noble S.L.	2018
10	Med-Score 24: A multivariable prediction model for poststernotomy mediastinitis 24A hours after admission to the intensive care unit. ( 29273422 )	Nieto-Cabrera M....SA!nchez-GarcA-a M.	2018
11	Fibrosing mediastinitis with pulmonary hypertension as a complication of pulmonary vein stenosis: A case report and review of the literature. ( 29369193 )	Li Y....Lu X.	2018
12	Enzymatic mediastinitis as a fearsome complication of pancreatic necrosectomy. ( 29931993 )		2018
13	Endovascular Management of SVC Syndrome due to Fibrosing Mediastinitis-A Feasibility and Safety Analysis. ( 29433409 )		2018
14	Recurrent Pneumonia due to Fibrosing Mediastinitis in a Teenage Girl: A Case Report with Long-Term Follow-Up. ( 29744231 )		2018
15	SurgicelAr packing remnants mimicking mediastinitis after adult cardiac surgery. ( 29365109 )		2018
16	Taking heed of the 'danger space': acute descending necrotising mediastinitis secondary to primary odontogenic infection. ( 29848536 )		2018
17	IgG4-related fibrosing mediastinitis diagnosed with computed tomography-guided percutaneous needle biopsy: Two case reports and a review of the literature. ( 29851832 )		2018
18	Mediastinitis superinfected by Achromobacter xylosoxidans. A case report. ( 29895453 )		2018
19	A giant thoracic aortic aneurysm causing multiple fistulas and mediastinitis. ( 30336274 )	Amandine D...Nicolas M	2018
20	Clinical and imaging spectrum of tuberculosis-associated fibrosing mediastinitis. ( 29356415 )	Liu T...Zhai Z	2018
21	A case of fibrosing mediastinitis complicated by pulmonary hypertension and right-sided heart failure. ( 30202958 )	Eshak N...Ziada K	2018
22	Fibrosing Mediastinitis: a Rare Cause of Unilateral Absent Lung Perfusion on a V/Q Scan. ( 30344792 )	Goldbach AR...Dadpravarar S	2018
23	Pulmonary Arterial Bypass Surgery for Fibrosing Mediastinitis Causing Severe Pulmonary Hypertension. ( 30447188 )	Cimenoglu B...Toker A	2018
24	Exceptional association of two species of bacteria causing mediastinitis: Haemophilus influenzae (H. influenzae) and Aggregatibacter aphrophilus (A. aphrophilus). ( 30115033 )	Belarj B...Elouennass M	2018
25	Poststernotomy mediastinitis: Early risk factors identified but hard to modify. ( 29113644 )	Conti V	2018
26	Complete excision of acute necrotic regression of thymoma mimicking an infected mediastinal cyst with mediastinitis using video-assisted thoracoscopic technique. ( 29997995 )	Kim YH...Kim IS	2018
27	Fulminant descending mediastinitis secondary to infectious mononucleosis. ( 30093999 )	Fuller GW...Rao JN	2018
28	Descending necrotizing mediastinitis after sequestrectomy in a patient with bisphosphonate-induced osteonecrosis of the jaw: A case report. ( 30101025 )	Tamanuki T...Matsuzaki H	2018
29	Senile Lemierre syndrome complicated with descending necrotizing mediastinitis: A case report. ( 30170383 )	Yang X...Sun ZY	2018
30	Spontaneous mediastinitis with multiple esophageal abscess in the esophagus. ( 30225188 )	Almorza T...Lalueza A	2018
31	Acute descending necrotizing mediastinitis: four years of experience at a hospital center in Madagascar. ( 30270835 )	Razafimanjato NNM...Rakotovao HJL	2018
32	Vacuum-Assisted Closure for Mediastinitis in Pediatric Cardiac Surgery: A Single-Center Experience. ( 30281163 )	Onan IS...Haydin S	2018
33	Usefulness of a temporary endovascular left ventricular assist system as a bridge to facilitate treatment of mediastinitis associated with a permanent device. ( 30396846 )	Mueller M...Krabatsch T	2018
34	Effective Combination of Different Surgical Strategies for Deep Sternal Wound Infection and Mediastinitis. ( 30404980 )	Tewarie L...Zayat R	2018
35	Descending necrotizing mediastinitis in a healthy young adult. ( 30425498 )	Ochi N...Takigawa N	2018
36	A Fatal Mediastinitis Due to a Neck Trauma from an Undeclared Assault. ( 30444943 )	Cascini F...Pascali VL	2018
37	Successful Treatment of a Late Diagnosed Esophageal Perforation with Mediastinitis and Pericardial Abscess. ( 30501839 )	Kupeli M...Dogan A	2018
38	The risk of mediastinitis and deep sternal wound infections with single and bilateral, pedicled and skeletonized internal thoracic arteries. ( 30505751 )	Lazar HL	2018
39	Risk factors for delayed oral dietary intake in patients with deep neck infections including descending necrotizing mediastinitis. ( 28825131 )	Hidaka H....Katori Y.	2017
40	Mediastinitis as a complication of minimally invasive diagnostic and mediastinal staging techniques. ( 29254905 )	Pereiro T....ValdAcs L.	2017
41	European Association for Cardio-Thoracic Surgery expert consensus statement on the prevention and management of mediastinitis. ( 28077503 )	Abu-Omar Y....Cardillo G.	2017
42	Fatal case of descending necrotising mediastinitis. ( 28705850 )	Sato R....Tokuda Y.	2017
43	Unexpected Fibrosing Mediastinitis Shown on FDG PET/CT in a Patient With IgG4-Related Disease. ( 28806261 )	Kan Y....Yang J.	2017
44	Challenges in Destination LVAD Therapy, Management of Mediastinitis and Device Infection, a Case Report. ( 28784570 )	van Valen R....Bogers A.J.J.C.	2017
45	Low antibodies titer and serological cross-reaction between Coxiella burnetii and Legionella pneumophila challenge the diagnosis of mediastinitis, an emerging Q fever clinical entity. ( 28779434 )	Edouard S....Raoult D.	2017
46	Utility of PET scan in diagnosis and monitoring descending necrotizing mediastinitis complicating Lemierre's syndrome. ( 28776174 )	Carandini T....Ceriani E.	2017
47	Idiopathic fibrosing mediastinitis mimicking nodal metastasis from breast cancer. ( 28114793 )	Okamoto K....Ichinose M.	2017
48	Predictors of Mediastinitis Risk after Coronary Artery Bypass Surgery: Applicability of Score in 1.322 Cases. ( 28832745 )	Oliveira F.D.S....Moraes M.A.P.	2017
49	Effect of polymyxin B-containing regimens on renal function for the treatment of carbapenem-resistant Enterobacteriacea mediastinitis. ( 29182906 )	Abboud C.S....Kiffer C.	2017
50	Chest Necrotizing Fasciitis with Mediastinitis. ( 28674375 )	Ohsaki A....Hirooka N.	2017

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Genes for Mediastinitis

Genes related to Mediastinitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MPO	Myeloperoxidase	Protein Coding	16.58	GeneCards inferred via : Publications (show sections)
2	DNM1	Dynamin 1	Protein Coding	16.29	DISEASES inferred ¹⁵
3	F5	Coagulation Factor V	Protein Coding	16.23	GeneCards inferred via : Publications (show sections)
4	CRP	C-Reactive Protein	Protein Coding	15.83	DISEASES inferred ¹⁵
5	RPS6KB2	Ribosomal Protein S6 Kinase B2	Protein Coding	15.24	DISEASES inferred ¹⁵
6	NKX2-6	NK2 Homeobox 6	Protein Coding	15.06	DISEASES inferred ¹⁵
7	TEF	TEF, PAR BZIP Transcription Factor	Protein Coding	14.98	DISEASES inferred ¹⁵
8	MAPKAPK3	Mitogen-Activated Protein Kinase-Activated Protein Kinase 3	Protein Coding	14.79	DISEASES inferred ¹⁵
9	RERE	Arginine-Glutamic Acid Dipeptide Repeats	Protein Coding	14.68	DISEASES inferred ¹⁵

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Variations for Mediastinitis

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Expression for Mediastinitis

Search GEO for disease gene expression data for Mediastinitis.

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Pathways for Mediastinitis

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GO Terms for Mediastinitis

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Sources for Mediastinitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia