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MCID: MDS022
MIFTS: 40

Mediastinitis

Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Mediastinitis

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MalaCards integrated aliases for Mediastinitis:

Name: Mediastinitis 12 44 15 73

Classifications:

ICD10: 33


External Ids:

Disease Ontology 12 DOID:819
ICD10 33 J98.5
ICD9CM 35 519.2
MeSH 44 D008480
NCIt 50 C26827
SNOMED-CT 68 47597000
UMLS 73 C0025064
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Summaries for Mediastinitis

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MalaCards based summary : Mediastinitis is related to pleural disease and pulmonary embolism, and has symptoms including chest pain and signs and symptoms. An important gene associated with Mediastinitis is MPO (Myeloperoxidase). The drugs Ticlopidine and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include b cells, lung and lymph node, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Mediastinitis is inflammation of the tissues in the mid-chest, or mediastinum. It can be either acute or... more...

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Related Diseases for Mediastinitis

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Diseases related to Mediastinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 596)
# Related Disease Score Top Affiliating Genes
1 pleural disease 29.7 CRP MPO
2 pulmonary embolism 29.2 CRP F5
3 diaphragmatic eventration 29.2 NKX2-6 TEF
4 peritonitis 29.1 CRP MPO
5 aortitis 28.9 CRP MPO RERE
6 aortic valve disease 2 28.5 CRP NKX2-6
7 fibrosing mediastinitis 12.4
8 primary mediastinal large b-cell lymphoma 12.2
9 primary mediastinal b-cell lymphoma 12.1
10 mediastinal cancer 12.1
11 malignant mediastinal neurogenic neoplasm 12.0
12 mediastinal lipomatosis 12.0
13 mediastinal gray zone lymphoma 12.0
14 mediastinal malignant lymphoma 12.0
15 mediastinal granular cell myoblastoma 12.0
16 mediastinal endodermal sinus tumors 12.0
17 benign mediastinal neurilemmoma 12.0
18 mediastinal neurilemmoma 12.0
19 childhood mediastinal neurogenic tumor 11.8
20 mediastinal osteogenic sarcoma 11.8
21 mediastinal melanocytic neurilemmoma 11.8
22 benign mediastinal psammomatous neurilemmoma 11.8
23 mediastinal mesenchymal tumor 11.8
24 igg4-related disease 11.2
25 fibrosclerosis, multifocal 11.1
26 lipomatosis, multiple symmetric 10.9
27 pagod syndrome 10.9
28 anemia, congenital dyserythropoietic, type ii 10.9
29 carney triad 10.9
30 mediastinum neuroblastoma 10.9
31 mediastinum sarcoma 10.9
32 malignant melanocytic peripheral nerve sheath tumor of mediastinum 10.8
33 lymphoma 10.6
34 mononeuritis multiplex 10.5 CRP MPO
35 b-cell lymphomas 10.5
36 rapidly progressive glomerulonephritis 10.5 CRP MPO
37 acquired angioedema 10.5 CRP F5
38 hypersensitivity vasculitis 10.5 CRP MPO
39 pulmonary aspergilloma 10.5 CRP MPO
40 hypersensitivity reaction type iii disease 10.5 CRP MPO
41 polyarteritis nodosa 10.5 CRP MPO
42 peripheral vertigo 10.5 CRP F5
43 proctitis 10.4 CRP MPO
44 multiple cranial nerve palsy 10.4 CRP MPO
45 pelvic inflammatory disease 10.4 CRP MPO
46 suppurative cholangitis 10.4 CRP MPO
47 teratoma 10.4
48 pleurisy 10.4 CRP MPO
49 appendicitis 10.3 CRP MPO
50 adenoma 10.3

Comorbidity relations with Mediastinitis via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease
Intermediate Coronary Syndrome Ischemic Heart Disease
Respiratory Failure

Graphical network of the top 20 diseases related to Mediastinitis:



Diseases related to Mediastinitis
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Symptoms & Phenotypes for Mediastinitis

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UMLS symptoms related to Mediastinitis:


chest pain, signs and symptoms

MGI Mouse Phenotypes related to Mediastinitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 MPO NKX2-6 RERE RPS6KB2 CRP DNM1
2 homeostasis/metabolism MP:0005376 9.5 F5 MPO NKX2-6 RPS6KB2 TEF CRP
3 mortality/aging MP:0010768 9.23 MAPKAPK3 MPO NKX2-6 RERE RPS6KB2 TEF
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Drugs & Therapeutics for Mediastinitis

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Drugs for Mediastinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ticlopidine Approved Phase 4 55142-85-3 5472
2
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
3
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
4 tannic acid Approved, Nutraceutical Phase 4
5 Fibrinolytic Agents Phase 4,Not Applicable
6 Coagulants Phase 4,Phase 3
7 Neurotransmitter Agents Phase 4,Phase 3
8 Hemostatics Phase 4,Phase 3
9 Cytochrome P-450 Enzyme Inhibitors Phase 4
10 Platelet Aggregation Inhibitors Phase 4
11 Purinergic P2 Receptor Antagonists Phase 4
12 Purinergic P2Y Receptor Antagonists Phase 4
13 insulin Phase 4
14 Hypoglycemic Agents Phase 4
15 Insulin, Globin Zinc Phase 4
16
Norepinephrine Approved Phase 3 51-41-2 439260
17
Mupirocin Approved, Investigational, Vet_approved Phase 3 12650-69-0 446596
18
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
19
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
20
Thrombin Approved, Investigational Phase 3
21 Adrenergic Agents Phase 3
22 Adrenergic Agonists Phase 3
23 Adrenergic alpha-Agonists Phase 3
24 Natriuretic Agents Phase 3
25 Vasoconstrictor Agents Phase 3
26 Vasopressins Phase 3
27 Peripheral Nervous System Agents Phase 3
28 Anti-Bacterial Agents Phase 3,Not Applicable
29 Arginine Vasopressin Phase 3
30 Autonomic Agents Phase 3
31 Anti-Infective Agents Phase 3,Not Applicable
32 Prednisolone acetate Phase 3
33 glucocorticoids Phase 3
34 Methylprednisolone acetate Phase 3
35 Methylprednisolone Hemisuccinate Phase 3
36 Gastrointestinal Agents Phase 3
37 Neuroprotective Agents Phase 3
38 Hormone Antagonists Phase 3
39 Hormones Phase 3
40 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
41 Prednisolone hemisuccinate Phase 3
42 Prednisolone phosphate Phase 3
43 Antiemetics Phase 3
44 Protective Agents Phase 3
45 Anti-Inflammatory Agents Phase 3
46 Antineoplastic Agents, Hormonal Phase 3
47 Protamines Phase 3
48 Vaccines Phase 2, Phase 3
49 arginine Nutraceutical Phase 3
50
Vancomycin Approved Not Applicable 1404-90-6 441141 14969

Interventional clinical trials:

(show all 50)
# Name Status NCT ID Phase Drugs
1 Improvement of Hemostasis Techniques After Median Sternotomy Unknown status NCT01134471 Phase 4
2 The Effect of Chest Tubes Using Active Clearance Technology® on the Incidence of Postoperative Atrial Fibrillation Unknown status NCT02808897 Phase 4
3 Rapid Sternal Closure System (TALON) Completed NCT00638014 Phase 4
4 Effect of Clopidogrel (Plavix) on Postoperative Bleeding in Patients Undergoing Coronary Artery Bypass Surgery. Completed NCT00724880 Phase 4 Clopidogrel;Clopidogrel;Clopidogrel
5 Randomized Trial of 2% Chlorhexidine-70% Isopropanol vs 5% Povidone Iodine-69% Ethanol for Skin Antisepsis in Reducing Surgical-site Infection After Cardiac Surgery Not yet recruiting NCT03560193 Phase 4 2%Chlorhexidine-70%Isopropanol;5%Povidone Iodine- 69%Ethanol
6 Tight Intra-Operative Glucose Control During Coronary Artery Bypass Surgery Terminated NCT00394303 Phase 4 Intraoperative continuous insulin infusion
7 SOLAR & ATRILAZE Atrial Fibrillation Trial Unknown status NCT00734058 Phase 3
8 Vasopressin Versus Norepinephrine for the Management of Shock After Cardiac Surgery Unknown status NCT01505231 Phase 3 Vasopressin;Norepinephrine
9 Concomitant Utilization of Radio Frequency Energy for Atrial Fibrillation (CURE-AF) Study Completed NCT00431834 Phase 3
10 Medtronic Concomitant Utilization of Radio Frequency for Atrial Fibrillation CURE-AF/Persistent Completed NCT00506493 Phase 3
11 Efficacy Study of Mupirocin on Infection After Coronary Artery Bypass Grafting Completed NCT01949935 Phase 3 Mupirocin
12 STeroids to REduce Systemic Inflammation After Neonatal Heart Surgery Recruiting NCT03229538 Phase 3 Methylprednisolone;Isotonic saline
13 Administration of Prothrombin Complex Concentrate vs. Standard Transfusion During/After Heart Transplantation Not yet recruiting NCT03341156 Phase 3 Kcentra;Frozen Plasma Product, Human
14 Efficacy, Immunogenicity, and Safety of a Single Dose of V710 in Adult Patients Scheduled for Cardiothoracic Surgery (V710-003 AM2) Terminated NCT00518687 Phase 2, Phase 3
15 The eMESH 1 Feasibility Study Recruiting NCT01676376 Phase 1, Phase 2
16 ESI With EUS to Differentiate T3 and T4 ESCC Unknown status NCT01930630 Phase 1
17 Factors Associated With Complications of Cervical Necrotizing Fasciitis Unknown status NCT02847234
18 Delayed Primary Versus Late Secondary Wound Closure in Sternum Infections Unknown status NCT01473979 Not Applicable
19 Intra-aortic Balloon Counterpulsation in Patients Undergoing Cardiac Surgery Unknown status NCT02143544 Not Applicable
20 Endoscopic-vacuum Assisted Closure of Intrathoracic Postsurgical Leaks Unknown status NCT00876551 Not Applicable
21 Goal Direct Therapy to Prevent Acute Kidney Injury Unknown status NCT02396901 Not Applicable
22 Accuracy and Safety of Endobronchial Ultrasound (EBUS) in Suspected Non-malignant Mediastinal Lymphadenopathy Unknown status NCT02398864 Not Applicable
23 Thrombolytic Therapy Versus Surgery for Obstructive Prosthetic Valve Thrombosis Unknown status NCT02243839 Not Applicable Thrombolytic Therapy
24 Topical Vancomycin in Prevention of Methicillin-Resistant Staphylococcal Related Mediastinitis in Patients Receiving Coronary Artery Bypass Graft Completed NCT00711685 Not Applicable
25 Physiotherapy Exercises in Patients With Sternal Instability After Cardiovascular Surgery Completed NCT02513576 Not Applicable
26 Role of Cerebral Oximetry in Reducing Postoperative Morbidity Following Cardiac Surgery Completed NCT02155868 Not Applicable
27 Evaluation of Primary Plating in Sternotomy Patients for Osteosynthesis and Pain Completed NCT00819286 Not Applicable
28 Perioperative Intra-Aortic Balloon Pump (IABP) in Coronary Artery Bypass Grafting (CABG) Operations in Patients With Severely Depressed Left Ventricular Function Completed NCT00881192 Not Applicable
29 Pharmacokinetics of Cefuroxime in Cardiac Surgery With Cardiopulmonary Bypass Completed NCT01228825
30 Impact of Microparticles in Blood on Transfused Patient Outcomes Completed NCT03041974
31 Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass Surgery Completed NCT01153360 Not Applicable liothyronine sodium;placebo
32 Glutamine to Improve Outcomes in Cardiac Surgery Completed NCT01704430 Not Applicable
33 Mediastinitis and Staphylococcus Aureus Recruiting NCT03262558
34 Open Lung Protective Ventilation in Cardiac Surgery Recruiting NCT02866578 Not Applicable
35 Feasibility of Transcatheter Aortic Valve Replacement in Low-Risk Patients With Symptomatic, Severe Aortic Stenosis Recruiting NCT02628899 Not Applicable
36 Study of the Combined Influence of Sepsis and Mechanical Ventilation on the Human Diaphragm Recruiting NCT03371602 Not Applicable
37 Registry for the Improvement of Postoperative OutcomeS in Cardiac and Thoracic surgEry Recruiting NCT03209674
38 Dumping Syndrome After Operation of Esophageal Atresia Type III Recruiting NCT02525705 Not Applicable
39 The Goal dIrected perFusion Trial in Cardiac Surgery Recruiting NCT02250131 Not Applicable
40 Eso-Sponge Registry Recruiting NCT02662777
41 Impact of Perivascular Tissue on Endothelial Function in Coronary Artery Bypass Grafting Recruiting NCT01834846 Not Applicable
42 Quality of Life After Ministernotomy Versus Full Sternotomy Aortic Valve Replacement Recruiting NCT02726087 Not Applicable
43 Assessment of Cerebral Blood Flow Asymmetry in Cardiac Surgery Patients Undergoing Hypothermic Circulatory Arrest Recruiting NCT03215589
44 Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2 Active, not recruiting NCT02073760
45 Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery Active, not recruiting NCT02068716
46 Predictability of Preoperative Hemoglobin A1c in Diabetic Patients Underwent Off-Pump Coronary Artery Bypass Surgery: A Retrospective Study. Active, not recruiting NCT03543449
47 Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation Enrolling by invitation NCT03508505
48 Finnish Registry of Transcatheter and Surgical Aortic Valve Replacement for Aortic Valve Stenosis: FinnValve Registry Enrolling by invitation NCT03385915
49 Medtronic Terminate AF Study Not yet recruiting NCT03546374 Not Applicable
50 Effects of a New Antimicrobial Dressing on Wound Healing and Incidence of Sternal Wound Infections Terminated NCT00203541 Not Applicable

Search NIH Clinical Center for Mediastinitis

Cochrane evidence based reviews: mediastinitis

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Genetic Tests for Mediastinitis

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Anatomical Context for Mediastinitis

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MalaCards organs/tissues related to Mediastinitis:

41
B Cells, Lung, Lymph Node, Heart, Thyroid, Myeloid, T Cells
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Publications for Mediastinitis

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Articles related to Mediastinitis:

(show top 50) (show all 2428)
# Title Authors Year
1
Primary mediastinal histiocytic sarcoma presenting as pleural effusion. ( 29756323 )
2018
2
Autologous stem cell transplantation for primary mediastinal B-cell lymphoma: long-term outcome and role of post-transplant radiotherapy. A report of the European Society for Blood and Marrow Transplantation. ( 29463854 )
2018
3
A Migratory Mishap: Giant Mediastinal Parathyroid Adenoma. ( 29360437 )
2018
4
Patient with mediastinitis caused by delayed mucosal damage after peroral endoscopic myotomy. ( 29656451 )
2018
5
Deep neck infection and descending mediastinitis as lethal complications of dentoalveolar infection: two rare case reports. ( 29980234 )
2018
6
Mediastinal angiosarcoma presenting as diffuse alveolar hemorrhage. ( 29719795 )
2018
7
Mediastinal monophasic synovial sarcoma with pericardial extension causing hemodynamic instability. ( 29765618 )
2018
8
18-FDG-PET in a patient cohort suspected for cardiac sarcoidosis: Right ventricular uptake is associated with pathological uptake in mediastinal lymph nodes. ( 29721764 )
2018
9
Metastatic mediastinal mature teratoma with malignant transformation in a young man with an adenocarcinoma in a Klinefelter's syndrome: Case report and review of the literature. ( 29673950 )
2018
10
A Rare Case of Mediastinal Bronchogenic Cyst Infected by <i>Salmonella enteritidis</i>. ( 29854533 )
2018
11
End-of-treatment and serial PET imaging in primary mediastinal B-cell lymphoma following dose-adjusted-EPOCH-R: A paradigm shift in clinical decision making. ( 29748435 )
2018
12
Fibrosing Mediastinitis: Uncommon Life-threatening Complication of Histoplasmosis. ( 29946500 )
2018
13
Extranodal Rosai-Dorfman Disease Presenting as a Mediastinal Mass with Pulmonary Artery Invasion. ( 29850299 )
2018
14
Metabolic heterogeneity on baseline 18FDG-PET/CT scan is a predictor of outcome in primary mediastinal B-cell lymphoma. ( 29720487 )
2018
15
Membranoproliferative glomerulonephritis-like findings for TAFRO syndrome, associated with an anterior mediastinal tumor: A case report. ( 29901607 )
2018
16
Superior vena cava obstruction by metastatic mediastinal testicular seminoma. Imaging of collateral pathways during gastrointestinal bleeding scintigraphy with <sup>99m</sup>Tc labeled red blood cells. ( 29636233 )
2018
17
Giant Cervical and Mediastinal Hemangioendothelioma Arising from Subclavian Vein. ( 29503064 )
2018
18
Granulomatous reaction of primary mediastinal seminoma leading to diagnostic delay: a case report. ( 29607195 )
2018
19
Long-term complete remission following tandem autologous stem cell transplantation and consolidative radiotherapy for refractory mediastinal gray-zone lymphoma. ( 29786758 )
2018
20
The Impact of the Medicaid Healthcare-Associated Condition Program on Mediastinitis Following Coronary Artery Bypass Graft. ( 29669607 )
2018
21
Effect of chlorhexidine skin disinfection and retrosternal gentamicin sponge on post-sternotomy mediastinitis: results from a prospective controlled registry of 2340 patients. ( 29409978 )
2018
22
Lethal fibrosing mediastinitis in a child possibly due to Mycobacterium tuberculosis. ( 29635837 )
2018
23
What is the standard of care for primary mediastinal B cell lymphoma; R-CHOP or DA-EPOCH-R? - Response to Melani etA al. ( 29528099 )
2018
24
Fibrosing mediastinitis-related pulmonary artery and vein stenosis-limiting chemotherapy. ( 29754128 )
2018
25
Anterior mediastinal leiomyosarcoma mimicking thymoma: A case report. ( 29924013 )
2018
26
Extracorporeal Membrane Oxygenation (ECMO)-Assisted Surgery for Mediastinal Goiter Removal. ( 29242007 )
2018
27
Septic shock from descending necrotizing mediastinitis - combined treatment with IgM-enriched immunoglobulin preparation and direct polymyxin B hemoperfusion: a case report. ( 29499757 )
2018
28
Group C strep mediastinitis. ( 29454509 )
2018
29
Med-Score 24: A multivariable prediction model for poststernotomy mediastinitis 24A hours after admission to the intensive care unit. ( 29273422 )
2018
30
Mediastinal extramedullary hematopoiesis in patient with beta-thalassemia major. ( 29887175 )
2018
31
Extended surgery using anterior mediastinal tracheostomy for recurrent mediastinal liposarcoma. ( 29415198 )
2018
32
STAT6 is a cargo of exportin 1: Biological relevance in primary mediastinal B-cell lymphoma. ( 29501729 )
2018
33
Fibrosing mediastinitis with pulmonary hypertension as a complication of pulmonary vein stenosis: A case report and review of the literature. ( 29369193 )
2018
34
Advances in the management of primary mediastinal large B-cell lymphoma. ( 29741502 )
2018
35
Successful surgical treatment of massive spontaneous hemothorax due to intrathoracic secondary degeneration of a neurofibroma from mediastinal involvement of type 1 neurofibromatosis. ( 29707374 )
2018
36
Clinical value of 11C-methionine positron emission tomography in persistent primary hyperparathyroidism-A case report with a mediastinal parathyroid adenoma. ( 29573598 )
2018
37
Somatic IL4R mutations in primary mediastinal large B-cell lymphoma lead to constitutive JAK-STAT signaling activation. ( 29467182 )
2018
38
3D-printing aided resection of intratracheal adenoid cystic carcinoma and mediastinal mature cystic teratoma in a 26-year-old female: a case report. ( 29607203 )
2018
39
Curious case of a black pleural effusion: Mediastinal teratoma presenting as massive pleural effusion. ( 29319045 )
2018
40
Clinical and molecular characteristics of unicentric mediastinal Castleman disease. ( 29850111 )
2018
41
Dieulafoy's disease with mediastinal arteriovenous malformation. ( 29353256 )
2018
42
Lactate dehydrogenase levels and 18F-FDG PET/CT metrics differentiate between mediastinal Hodgkin's lymphoma and primary mediastinal B-cell lymphoma. ( 29672465 )
2018
43
Mediastinal cystic mass as atypical location of visceral leishmaniasis. ( 29398008 )
2018
44
Study of the radiologic features of Legionnaires' disease with mediastinal adenopathy: Legionella or lymphoma? ( 29383455 )
2018
45
Near-infrared intraoperative imaging during resection of an anterior mediastinal soft tissue sarcoma. ( 29387401 )
2018
46
Mediastinal lymphangioma in an adult. ( 29397964 )
2018
47
Primary mediastinal large B-cell lymphoma: Outcome of a series of pediatric patients treated with high-dose methotrexate and cytarabine plus anti-CD20. ( 29049862 )
2018
48
Ruxolitinib significantly enhances <i>in vitro</i> apoptosis in Hodgkin lymphoma and primary mediastinal B-cell lymphoma and survival in a lymphoma xenograft murine model. ( 29515770 )
2018
49
A study of the dosimetric characteristics between different fixed-field IMRT and VMAT in early-stage primary mediastinal B-cell lymphoma. ( 28935521 )
2018
50
Enzymatic mediastinitis as a fearsome complication of pancreatic necrosectomy. ( 29931993 )
2018
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Variations for Mediastinitis

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Expression for Mediastinitis

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Search GEO for disease gene expression data for Mediastinitis.
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Pathways for Mediastinitis

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GO Terms for Mediastinitis

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Sources for Mediastinitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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