Aliases & Classifications for Mediastinitis

MalaCards integrated aliases for Mediastinitis:

Name: Mediastinitis 12 44 15 72

External Ids:

Disease Ontology 12 DOID:819
ICD9CM 35 519.2
MeSH 44 D008480
NCIt 50 C26827
SNOMED-CT 68 47597000
ICD10 33 J98.51
UMLS 72 C0025064

Summaries for Mediastinitis

Disease Ontology : 12 A connective tissue disease characterized by inflammation located in the mediastinum, which extends from the diaphragm to the thoracic inlet and between the pleural cavities.

MalaCards based summary : Mediastinitis is related to pleurisy and pulmonary embolism, and has symptoms including chest pain and signs and symptoms. An important gene associated with Mediastinitis is MPO (Myeloperoxidase). The drugs Clopidogrel and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 75 Mediastinitis is inflammation of the tissues in the mid-chest, or mediastinum. It can be either acute or... more...

Related Diseases for Mediastinitis

Diseases related to Mediastinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1367)
# Related Disease Score Top Affiliating Genes
1 pleurisy 30.7 MPO CRP
2 pulmonary embolism 30.5 F5 CRP
3 lemierre's syndrome 30.3 DNM1 CRP
4 bronchitis 30.1 MPO CRP
5 peritonitis 29.9 MPO CRP
6 vascular disease 29.9 MPO F5 CRP
7 hypersensitivity vasculitis 29.8 MPO CRP
8 polyarteritis nodosa 29.7 MPO CRP
9 aortitis 29.6 RERE MPO CRP
10 proteasome-associated autoinflammatory syndrome 1 28.9 MPO CRP
11 fibrosing mediastinitis 12.7
12 primary mediastinal large b-cell lymphoma 12.5
13 primary mediastinal b-cell lymphoma 12.5
14 mediastinal cancer 12.4
15 malignant mediastinal neurogenic neoplasm 12.3
16 mediastinal lipomatosis 12.3
17 mediastinal malignant lymphoma 12.3
18 mediastinal gray zone lymphoma 12.3
19 mediastinal neurilemmoma 12.3
20 benign mediastinal neurilemmoma 12.3
21 mediastinal endodermal sinus tumors 12.3
22 mediastinal granular cell myoblastoma 12.3
23 mediastinal mesenchymal tumor 12.2
24 childhood mediastinal neurogenic tumor 12.1
25 mediastinal osteogenic sarcoma 12.1
26 mediastinal melanocytic neurilemmoma 12.1
27 benign mediastinal psammomatous neurilemmoma 12.1
28 genetic respiratory or mediastinal malformation 12.1
29 respiratory or mediastinal malformation 12.1
30 syndromic respiratory or mediastinal malformation 12.1
31 non-syndromic respiratory or mediastinal malformation 12.1
32 pulmonary hypoplasia, primary 11.5
33 carney triad 11.5
34 pulmonary venoocclusive disease 11.5
35 igg4-related disease 11.5
36 fibrosclerosis, multifocal 11.4
37 lipomatosis, multiple symmetric 11.2
38 pagod syndrome 11.2
39 anemia, congenital dyserythropoietic, type ii 11.2
40 mediastinum neuroblastoma 11.2
41 mediastinum sarcoma 11.2
42 malignant melanocytic peripheral nerve sheath tumor of mediastinum 11.1
43 teratoma 10.9
44 lung cancer 10.8
45 lymphoma 10.8
46 b-cell lymphoma 10.8
47 thymoma 10.7
48 thymoma, familial 10.7
49 sarcoidosis 1 10.7
50 adenoma 10.7

Comorbidity relations with Mediastinitis via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease
Intermediate Coronary Syndrome Respiratory Failure

Graphical network of the top 20 diseases related to Mediastinitis:



Diseases related to Mediastinitis

Symptoms & Phenotypes for Mediastinitis

UMLS symptoms related to Mediastinitis:


chest pain, signs and symptoms

MGI Mouse Phenotypes related to Mediastinitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 CRP DNM1 F5 MPO RERE RPS6KB2
2 homeostasis/metabolism MP:0005376 9.5 CRP DNM1 F5 MPO PPT1 RPS6KB2
3 mortality/aging MP:0010768 9.23 DNM1 F5 MAPKAPK3 MPO PPT1 RERE

Drugs & Therapeutics for Mediastinitis

Drugs for Mediastinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
2
Ethanol Approved Phase 4 64-17-5 702
3
Iodine Approved, Investigational Phase 4 7553-56-2 807
4
Povidone Approved Phase 4 9003-39-8
5
Povidone-iodine Approved Phase 4 25655-41-8
6
Histamine Approved, Investigational Phase 4 51-45-6 774
7
Sodium citrate Approved, Investigational Phase 4 68-04-2
8
Ranitidine Approved Phase 4 66357-35-5, 66357-59-3 3001055
9
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
10 Purinergic P2Y Receptor Antagonists Phase 4
11 Purinergic P2 Receptor Antagonists Phase 4
12 Platelet Aggregation Inhibitors Phase 4
13 Micronutrients Phase 4
14 Disinfectants Phase 4
15 Chlorhexidine gluconate Phase 4
16 Anti-Infective Agents, Local Phase 4
17 Central Nervous System Depressants Phase 4
18 Nutrients Phase 4
19 Plasma Substitutes Phase 4
20 Dermatologic Agents Phase 4
21 cadexomer iodine Phase 4
22 Blood Substitutes Phase 4
23 Trace Elements Phase 4
24 Neurotransmitter Agents Phase 4
25 Gastrointestinal Agents Phase 4
26 Antacids Phase 4
27 Citrate Phase 4
28
Stevioside Phase 4 57817-89-7 548198
29 Stevia Phase 4
30
Histamine Phosphate Phase 4 51-74-1 65513
31 Histamine Antagonists Phase 4
32 Anti-Ulcer Agents Phase 4
33 Bismuth tripotassium dicitrate Phase 4
34 Histamine H2 Antagonists Phase 4
35
Bismuth Phase 4 7440-69-9 16682734 105143
36 Ranitidine bismuth citrate Phase 4
37 Immunologic Factors Phase 2, Phase 3
38 Vaccines Phase 2, Phase 3
39
Vancomycin Approved 1404-90-6 441141 14969
40
Daptomycin Approved, Investigational 103060-53-3 16129629
41
Pancrelipase Approved, Investigational 53608-75-6
42
Creatine Approved, Investigational, Nutraceutical 57-00-1 586
43 insulin
44 Insulin, Globin Zinc
45 Hypoglycemic Agents
46 methicillin
47 Antibiotics, Antitubercular
48 Cola
49 pancreatin
50 Liver Extracts

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Reinforced Sternal Closure Using Osteoconductive Biologic Bone Cement (Kryptonite) in Patients Undergoing Coronary Artery Bypass Grafting Unknown status NCT01261858 Phase 4
2 A Randomized, Controlled, Phase 4 Study of Sternal Plating (Rapid Sternal Closure System, KLS Martin L.P.) in Cardiac Surgical Subjects at Higher Risk for Sternal Wound Complications. Completed NCT00638014 Phase 4
3 Effect of Clopidogrel (Plavix) on Postoperative Bleeding in Patients Undergoing Coronary Artery Bypass Surgery. A Prospective Randomized Controlled Study Completed NCT00724880 Phase 4 Clopidogrel;Clopidogrel;Clopidogrel
4 An Open Label, Multicenter, Randomized Trial of 2% Chlorhexidine-70% Isopropanol vs 5% Povidone Iodine-69% Ethanol for Skin Antisepsis in Reducing Surgical-site Infection After Cardiac Surgery Recruiting NCT03560193 Phase 4 2%Chlorhexidine-70%Isopropanol;5%Povidone Iodine- 69%Ethanol
5 Stress Ulcer Prophylaxis Versus Placebo - a Blinded Randomized Control Trial to Evaluate the Safety of Two Strategies in Critically Ill Infants With Congenital Heart Disease Recruiting NCT03667703 Phase 4 Ranitidine;Placebo
6 A Randomized, Multicenter, Double-Blind, Group-Sequential Study to Evaluate the Efficacy, Immunogenicity, and Safety of a Single Dose of Merck 0657nI Staphylococcus Aureus Vaccine (V710) in Adult Patients Scheduled for Cardiothoracic Surgery Terminated NCT00518687 Phase 2, Phase 3
7 Surgical Ablation Versus No Surgical Ablation for Patients With Persistent or Longstanding Persistent Atrial Fibrillation (AF) Undergoing Mitral Valve Surgery Completed NCT00903370 Phase 2
8 Factors Associated With Complications of Cervical Necrotizing Fasciitis Unknown status NCT02847234
9 Immunological and Bacteriological Approaches to the Development of Postoperative Mediastinitis With Staphylococcus Aureus Unknown status NCT03262558
10 Endoscopic - Vacuum Assisted Closure of Intrathoracic Postsurgical Leaks Unknown status NCT00876551
11 Delayed Primary Versus Late Secondary Wound Closure in the Treatment of Postsurgical Sternum Osteomyelitis Unknown status NCT01473979
12 Strict or Liberal Insulin Protocol Following Coronary Artery Bypass Graft (CABG) Surgery Unknown status NCT01033916
13 A Multi-center, Randomized Controlled Trial of Goal-directed Perfusion in Cardiac Surgery Unknown status NCT02250131
14 Post-Surgical Mediastinitis: Retrospective Study of Cases Treated Within the CHU Brugmann Hospital Completed NCT03922191
15 A Randomized, Controlled Study of Physiotherapy Exercises in Patients With Sternal Instability Due to Mediastinitis After Cardiovascular Surgery Completed NCT02513576
16 A Prospective, Randomized-Controlled, Multicenter Study Evaluating Primary Plating in High-Risk Median Sternotomy Patients for Osteosynthesis and Pain Completed NCT00819286
17 Topical Vancomycin in Prevention of Methicillin-Resistant Staphylococcal Related Mediastinitis in Patients Receiving Coronary Artery Bypass Graft Completed NCT00711685
18 Evaluation of Plasma Concentrations and Pharmacokinetics of Cefuroxime Administered Prophylactically in Patients Undergoing Coronary Surgery With Cardiopulmonary Bypass Completed NCT01228825
19 Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2 Completed NCT02073760
20 Factors to Obstructive Granulation Tissue Formation After Ultraflex Stenting in Benign Tracheal Narrowing Completed NCT01006200
21 Achromobacter Xylosoxidans Infections : Epidemiology and Environmental Investigations Completed NCT03429283
22 Prospective Randomized Clinical Trial on Delay Phenomenon Utility in Preventing Oesophagogastric Anastomotic Dehiscence After Ivor-Lewis Esophagectomy. Pilot Study. Completed NCT02432794
23 A Study of the Evalve® Cardiovascular Valve Repair (MitraClip®) System Endovascular Valve Edge-to-Edge REpair STudy (EVEREST II) EVEREST II High Risk Registry Completed NCT01940120
24 Acute Kidney Injury During Daptomycin Versus Vancomycin Treatment in Cardiovascular Critically Ill Patients: a Propensity Score Matched Analysis Completed NCT03961503 Daptomycin (DAP) treatment;Vancomycin (VAN) treatment
25 Management Practices and the Risk of Infection Following Cardiac Surgery Completed NCT01089712
26 Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery Completed NCT02068716
27 Perioperative IABP in CABG Operations in Patients With Severely Depressed Left Ventricular Function: a Randomized, Controlled Trial Completed NCT00881192
28 Prospective Randomized Controlled Trial Comparing Side to Side Stapled and Hand Sewn Esophagogastric Anastomosis in the Neck Completed NCT00497549
29 Registry for the Improvement of Postoperative OutcomeS in Cardiac and Thoracic surgEry Recruiting NCT03209674
30 Creation of a Biospecimen Repository From Patients With Interstitial Lung Diseases (ILD) Recruiting NCT03478826
31 Flux Measurement and Outcome in Major Abdominal Surgery Recruiting NCT02612883
32 Feasibility of Transcatheter Aortic Valve Replacement in Low-Risk Patients With Symptomatic, Severe Aortic Stenosis Recruiting NCT02628899
33 Impact of the Use of Three Dressings in the Prevention of Surgical Wound Infection in Patients Undergoing Mayor Cardiac Surgery: a Clinical Prospective and Randomized Study Not yet recruiting NCT03905213
34 Modified Endotracheal Balloon Dilator to Improve Oxygenation During Airway Procedures in Children With Tracheal Stenosis Not yet recruiting NCT03411928
35 Pharmacokinetics of Post Operative Cefuroxime in Infants Undergoing Cardiac Surgery Withdrawn NCT02850250 Cefuroxime

Search NIH Clinical Center for Mediastinitis

Cochrane evidence based reviews: mediastinitis

Genetic Tests for Mediastinitis

Anatomical Context for Mediastinitis

MalaCards organs/tissues related to Mediastinitis:

41
Heart, Lung, Bone, Skin, Liver, Kidney, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Mediastinitis:

19
Mediastinum

Publications for Mediastinitis

Articles related to Mediastinitis:

(show top 50) (show all 3792)
# Title Authors PMID Year
1
Mediastinal Mucormycosis: Case report, review of literature and treatment with continuous liposomal amphotericin B irrigation. 38
31044442 2019
2
Tracheal Injury Prior to Sternotomy: A Cautionary Tale. 38
30709327 2019
3
Pediatric Tracheal Surgery: A 25-year Review of Slide Tracheoplasty and Tracheal Resection. 38
31400322 2019
4
An Unusual Case of Descending Necrotizing Mediastinitis. 38
30651175 2019
5
Fibrosing mediastinitis mimicking a lung carcinoma. 38
31368497 2019
6
Concordance between superficial swab and deep sampling in post-sternotomy mediastinitis: Single center experience. 38
31005566 2019
7
Management of Less-Than-Severe Aortic Stenosis During Coronary Bypass: A Systematic Review and Meta-Analysis. 38
31185776 2019
8
TEVAR for Secondary Aortobronchial Fistulas: Two Cases with Favorable Long-term Outcomes. 38
30825509 2019
9
The Impact of Preoperative Negative-Pressure Wound Therapy on Pectoralis Major Muscle Flap Reconstruction for Deep Sternal Wound Infections. 38
30882416 2019
10
Is Negative-Pressure Wound Therapy a "Bridge to Reconstruction" for Poststernotomy Mediastinitis? A Systematic Review. 38
31361268 2019
11
A Fatal Mediastinitis Due to a Neck Trauma from an Undeclared Assault. 38
30444943 2019
12
Descending cervical mediastinitis: the multidisciplinary surgical approach. 38
31093735 2019
13
Mediastinitis in the intensive care unit patient: a narrative review. 38
31306791 2019
14
Rituximab to Treat Fibrosing Mediastinitis-Associated Recurrent Hemoptysis. 38
31356339 2019
15
Experience of the use of octreotide for refractory gastrointestinal bleeding in a patient with Jarvik2000® left ventricular assist device. 38
31338629 2019
16
Cellulose-Derived Absorbable Hemostatic Product as a Risk Factor for Mediastinitis after Cardiac Surgery. 38
30785856 2019
17
Mediastinitis in open heart surgery: a systematic review and meta-analysis of risk factors. 38
31290699 2019
18
Comment on "A case of Mycobacterium chelonae mediastinitis and acute humoral rejection after heart transplantation". 38
31197871 2019
19
Hyperbaric oxygen therapy in a case of cervical abscess extending to anterior mediastinum, with isolation of Prevotella corporis. 38
31296620 2019
20
Severe mediastinitis over a month after endobronchial ultrasound-guided transbronchial needle aspiration. 38
31007930 2019
21
Vacuum-assisted closure versus closed irrigation for deep sternal wound infection treatment in infants: a propensity score-matched study. 38
31361302 2019
22
Minimization of Surgical Site Infections in Patients With Delayed Sternal Closure After Pediatric Cardiac Surgery. 38
31307311 2019
23
Application techniques of a novel hemostat in cardiac operations: HEMOBLAST. 38
31348840 2019
24
Predictive models of surgical site infections after coronary surgery: insights from a validation study on 7090 consecutive patients. 38
30653998 2019
25
Sternal allograft transplantation for anterior chest wall reconstruction after sternectomy. 38
31347797 2019
26
Iatrogenic mediastinitis in bronchiolitis: Importance of avoiding pharyngeal aspiration. 38
31278025 2019
27
Unilateral Pedicled Pectoralis Major Harvested by Endoscopic-Assisted Method Achieves Adequate Management of Sternal Infection and Mediastinitis. 38
31362322 2019
28
Continuous venovenous hemodiafiltration using cytokine-adsorbing hemofilters as adjuvant therapy for anaerobic descending necrotizing mediastinitis: a case report. 38
31272492 2019
29
Mediastinitis as complication of odontogenic infection: A case report. 38
31187775 2019
30
Treatment of a broncho-esophageal fistula complicated by severe ARDS. 38
30417214 2019
31
[Failure of Endo-VAC or Stenting Therapy after Oesophageal Anastomotic Insufficiency - How to Avoid Oesophagectomy]. 38
30646416 2019
32
Current indications for the intrathoracic transposition of the omentum. 38
31182112 2019
33
Open peroral endoscopic myotomy for the treatment of achalasia: a case series of 82 cases. 38
31175357 2019
34
Ambulatory setting of patients with surgical site infections after a cardiac intervention. 38
31241655 2019
35
Computed tomography improves the differentiation of infectious mediastinitis from normal postoperative changes after sternotomy in cardiac surgery. 38
30631921 2019
36
Comparison of enteral nutrition with total parenteral nutrition for patients with locally advanced unresectable esophageal cancer harboring dysphagia in definitive chemoradiotherapy. 38
31219161 2019
37
[Acute Facial Swelling Following Dental Procedure - an Allergic Reaction?] 38
31212334 2019
38
A giant thoracic aortic aneurysm causing multiple fistulas and mediastinitis. 38
30336274 2019
39
Pulmonary Arterial Bypass Surgery for Fibrosing Mediastinitis Causing Severe Pulmonary Hypertension. 38
30447188 2019
40
Preoperative screening for nasal carriage of methicillin-resistant Staphylococcus aureus in patients undergoing general thoracic surgery. 38
31191769 2019
41
Clinical Outcomes of Synchronous Laparoscopic Cholecystectomy with Coronary Artery Revascularization. 38
31237549 2019
42
Massive Bilateral Neck Abscess and Acute Mediastinitis Following Dental Implant Surgery. 38
31058725 2019
43
Clinical-care protocol for preventing mediastinitis after coronary artery bypass graft surgery: A quality improvement initiative from a private hospital. 38
30924558 2019
44
[Clinical study of cervical necrotizing fasciitis accompanied with descending necrotizing mediastinitis treated with cervical double parallel incision combined with mediastinoscope or thoracoscope]. 38
31091563 2019
45
Tracheo-oesophageal fistula in a case of button battery ingestion: CT virtual bronchoscopy imaging. 38
31088819 2019
46
Robot-assisted esophagogastric reconstruction in minimally invasive Ivor Lewis esophagectomy. 38
31285878 2019
47
Acute esophageal necrosis with esophagus perforation treated by thoracoscopic subtotal esophagectomy and reconstructive surgery on a secondary esophageal stricture: a case report. 38
31069560 2019
48
Variation between hospitals in outcomes following cardiac surgery in the UK. 38
30854865 2019
49
Does CHA2DS2-VASc Score Predict MACE in Patients Undergoing Isolated Coronary Artery Bypass Grafting Surgery? 38
31112030 2019
50
Multimodality Imaging of Focal and Diffuse Fibrosing Mediastinitis. 38
30951437 2019

Variations for Mediastinitis

Expression for Mediastinitis

Search GEO for disease gene expression data for Mediastinitis.

Pathways for Mediastinitis

GO Terms for Mediastinitis

Biological processes related to Mediastinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of synapse structure or activity GO:0050803 8.62 PPT1 DNM1

Sources for Mediastinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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