Aliases & Classifications for Mediastinitis

MalaCards integrated aliases for Mediastinitis:

Name: Mediastinitis 12 43 15 71

External Ids:

Disease Ontology 12 DOID:819
ICD9CM 34 519.2
MeSH 43 D008480
NCIt 49 C26827
SNOMED-CT 67 373409004
ICD10 32 J98.51
UMLS 71 C0025064

Summaries for Mediastinitis

Disease Ontology : 12 A connective tissue disease characterized by inflammation located in the mediastinum, which extends from the diaphragm to the thoracic inlet and between the pleural cavities.

MalaCards based summary : Mediastinitis is related to pleural empyema and hemopericardium, and has symptoms including chest pain and signs and symptoms. An important gene associated with Mediastinitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Phospholipase D signaling pathway and Folate Metabolism. The drugs Clopidogrel and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include mediastinum, heart and lung, and related phenotypes are cardiovascular system and digestive/alimentary

Wikipedia : 74 Mediastinitis is inflammation of the tissues in the mid-chest, or mediastinum. It can be either acute or... more...

Related Diseases for Mediastinitis

Diseases related to Mediastinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1618)
# Related Disease Score Top Affiliating Genes
1 pleural empyema 31.0 F2 CRP ALB
2 hemopericardium 30.7 F3 F2
3 lung abscess 30.5 LACTB CRP ALB
4 constrictive pericarditis 30.5 ZIC3 CRP ALB
5 epiglottitis 30.5 LACTB CRP
6 actinomycosis 30.4 INS CRP ALB
7 pharyngitis 30.4 LACTB CRP ALB
8 nocardiosis 30.4 LACTB CRP
9 bronchopneumonia 30.4 MPO CRP ALB
10 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 30.3 TTR CRP ALB
11 acute pancreatitis 30.3 MPO INS CRP ALB
12 hyperthyroidism 30.3 INS CRP ALB
13 diaphragmatic hernia, congenital 30.3 TEF ATP4A ATP12A
14 bronchitis 30.3 MPO LACTB CRP ALB
15 hernia, hiatus 30.2 TEF CRP ATP4A ATP12A
16 aortitis 30.2 MPO CRP
17 amyloidosis 30.1 TTR INS CRP ALB
18 pleural disease 30.1 F2 CRP ALB
19 laryngitis 30.1 CRP ATP4A ATP12A
20 aortic valve insufficiency 30.1 ZIC3 CRP ALB
21 cardiac tamponade 30.0 F3 F2 CRP ALB
22 neutropenia 30.0 MPO LACTB CRP ALB
23 peritonitis 30.0 MPO F2 CRP ALB
24 bacterial pneumonia 30.0 LACTB CRP ALB
25 pancytopenia 30.0 TTR MPO CRP ALB
26 esophageal disease 30.0 TEF ATP4A ATP12A ALB
27 mucormycosis 30.0 RHNO1 INS CRP
28 acute laryngitis 29.9 ATP4A ATP12A
29 gastroenteritis 29.9 LACTB CRP ALB
30 diverticulitis 29.9 CRP ATP4A ATP12A ALB
31 peptic ulcer disease 29.9 INS ATP4A ATP12A ALB
32 pulmonary fibrosis, idiopathic 29.9 CRP ATP4A ATP12A ALB
33 peptic esophagitis 29.9 ATP4A ATP12A ALB
34 heart valve disease 29.8 F2 CRP ALB
35 tracheomalacia 29.8 TEF RHNO1 ATP4A ATP12A
36 deficiency anemia 29.8 INS CRP ATP4A ATP12A ALB
37 thrombophilia due to thrombin defect 29.8 F5 F3 F2
38 sclerosing cholangitis 29.8 MPO F2 ALB
39 intestinal tuberculosis 29.8 CRP ALB
40 pelvic inflammatory disease 29.8 MPO LACTB CRP
41 coronary aneurysm 29.7 CRP ALB
42 interstitial nephritis 29.7 CRP ATP4A ATP12A ALB
43 hypersensitivity vasculitis 29.7 MPO CRP ALB
44 syphilis 29.7 F2 CRP ALB
45 multiple endocrine neoplasia, type i 29.7 INS ATP4A ATP12A
46 endocarditis 29.7 TTR LACTB F2 CRP ALB
47 severe cutaneous adverse reaction 29.7 CRP ATP4A ATP12A
48 otitis media 29.7 MPO LACTB CRP ALB
49 uremia 29.7 INS CRP ALB
50 amyloid tumor 29.7 TTR INS

Comorbidity relations with Mediastinitis via Phenotypic Disease Network (PDN):

Familial Atrial Fibrillation Heart Disease
Intermediate Coronary Syndrome Respiratory Failure

Graphical network of the top 20 diseases related to Mediastinitis:

Diseases related to Mediastinitis

Symptoms & Phenotypes for Mediastinitis

UMLS symptoms related to Mediastinitis:

chest pain, signs and symptoms

MGI Mouse Phenotypes related to Mediastinitis:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 ALB CRP DNM1 F2 F3 F5
2 digestive/alimentary MP:0005381 9.5 ALB ATP12A ATP4A F2 INS TTR
3 homeostasis/metabolism MP:0005376 9.47 ALB ATP12A ATP4A CRP DNM1 F2

Drugs & Therapeutics for Mediastinitis

Drugs for Mediastinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
Iodine Approved, Investigational Phase 4 7553-56-2 807
Ethanol Approved Phase 4 64-17-5 702
Povidone Approved Phase 4 9003-39-8
Povidone-iodine Approved Phase 4 25655-41-8
Histamine Approved, Investigational Phase 4 51-45-6 774
Famotidine Approved Phase 4 76824-35-6 3325
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
Alfacalcidol Approved, Nutraceutical Phase 4 41294-56-8 5282181
11 Trace Elements Phase 4
12 Vitamins Phase 4
13 Hydroxycholecalciferols Phase 4
14 Nutrients Phase 4
15 Micronutrients Phase 4
16 Calciferol Phase 4
17 Purinergic P2Y Receptor Antagonists Phase 4
18 Platelet Aggregation Inhibitors Phase 4
19 Chlorhexidine gluconate Phase 4
20 Anti-Infective Agents, Local Phase 4
21 Plasma Substitutes Phase 4
22 cadexomer iodine Phase 4
23 Disinfectants Phase 4
24 Blood Substitutes Phase 4
25 Neurotransmitter Agents Phase 4
26 Antacids Phase 4
27 Anti-Ulcer Agents Phase 4
28 Histamine Antagonists Phase 4
29 Histamine H2 Antagonists Phase 4
Histamine Phosphate Phase 4 51-74-1 65513
31 Gastrointestinal Agents Phase 4
32 Vaccines Phase 2, Phase 3
33 Immunologic Factors Phase 2, Phase 3
Vancomycin Approved 1404-90-6 14969 441141
Daptomycin Approved, Investigational 103060-53-3 16129629
Pancrelipase Approved, Investigational 53608-75-6
Creatine Approved, Investigational, Nutraceutical 57-00-1 586
38 Insulin, Globin Zinc
39 insulin
40 Antibiotics, Antitubercular
41 methicillin
42 Liver Extracts
43 Cola
44 pancreatin

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 Reinforced Sternal Closure Using Osteoconductive Biologic Bone Cement (Kryptonite) in Patients Undergoing Coronary Artery Bypass Grafting Unknown status NCT01261858 Phase 4
2 Short Term Effect of Vitamin D Supplementation on the Clinical Outcomes in Patients Undergoing Valve Replacement Surgery Completed NCT04085770 Phase 4 Alfacalcidol 1 MCG Oral Capsule
3 A Randomized, Controlled, Phase 4 Study of Sternal Plating (Rapid Sternal Closure System, KLS Martin L.P.) in Cardiac Surgical Subjects at Higher Risk for Sternal Wound Complications. Completed NCT00638014 Phase 4
4 Effect of Clopidogrel (Plavix) on Postoperative Bleeding in Patients Undergoing Coronary Artery Bypass Surgery. A Prospective Randomized Controlled Study Completed NCT00724880 Phase 4 Clopidogrel;Clopidogrel;Clopidogrel
5 An Open Label, Multicenter, Randomized Trial of 2% Chlorhexidine-70% Isopropanol vs 5% Povidone Iodine-69% Ethanol for Skin Antisepsis in Reducing Surgical-site Infection After Cardiac Surgery Recruiting NCT03560193 Phase 4 2%Chlorhexidine-70%Isopropanol;5%Povidone Iodine- 69%Ethanol
6 Stress Ulcer Prophylaxis Versus Placebo - a Blinded Randomized Control Trial to Evaluate the Safety of Two Strategies in Critically Ill Infants With Congenital Heart Disease Recruiting NCT03667703 Phase 4 Famotidine;Placebo
7 Comparison of Fibrinogen Concentrate and Cryoprecipitate in Pediatric Cardiac Surgery Patients Not yet recruiting NCT04376762 Phase 4 Fibrinogen;Cryoprecipitate
8 A Randomized, Multicenter, Double-Blind, Group-Sequential Study to Evaluate the Efficacy, Immunogenicity, and Safety of a Single Dose of Merck 0657nI Staphylococcus Aureus Vaccine (V710) in Adult Patients Scheduled for Cardiothoracic Surgery Terminated NCT00518687 Phase 2, Phase 3
9 Surgical Ablation Versus No Surgical Ablation for Patients With Persistent or Longstanding Persistent Atrial Fibrillation (AF) Undergoing Mitral Valve Surgery Completed NCT00903370 Phase 2
10 Factors Associated With Complications of Cervical Necrotizing Fasciitis Unknown status NCT02847234
11 Immunological and Bacteriological Approaches to the Development of Postoperative Mediastinitis With Staphylococcus Aureus Unknown status NCT03262558
12 Endoscopic - Vacuum Assisted Closure of Intrathoracic Postsurgical Leaks Unknown status NCT00876551
13 Delayed Primary Versus Late Secondary Wound Closure in the Treatment of Postsurgical Sternum Osteomyelitis Unknown status NCT01473979
14 Strict or Liberal Insulin Protocol Following Coronary Artery Bypass Graft (CABG) Surgery Unknown status NCT01033916
15 Modified Endotracheal Balloon Dilator to Improve Oxygenation During Airway Procedures in Children With Tracheal Stenosis Unknown status NCT03411928
16 A Multi-center, Randomized Controlled Trial of Goal-directed Perfusion in Cardiac Surgery Unknown status NCT02250131
17 Post-Surgical Mediastinitis: Retrospective Study of Cases Treated Within the CHU Brugmann Hospital Completed NCT03922191
18 A Randomized, Controlled Study of Physiotherapy Exercises in Patients With Sternal Instability Due to Mediastinitis After Cardiovascular Surgery Completed NCT02513576
19 A Prospective, Randomized-Controlled, Multicenter Study Evaluating Primary Plating in High-Risk Median Sternotomy Patients for Osteosynthesis and Pain Completed NCT00819286
20 Evaluation of Plasma Concentrations and Pharmacokinetics of Cefuroxime Administered Prophylactically in Patients Undergoing Coronary Surgery With Cardiopulmonary Bypass Completed NCT01228825
21 Topical Vancomycin in Prevention of Methicillin-Resistant Staphylococcal Related Mediastinitis in Patients Receiving Coronary Artery Bypass Graft Completed NCT00711685
22 Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2 Completed NCT02073760
23 Factors to Obstructive Granulation Tissue Formation After Ultraflex Stenting in Benign Tracheal Narrowing Completed NCT01006200
24 Achromobacter Xylosoxidans Infections : Epidemiology and Environmental Investigations Completed NCT03429283
25 Prospective Randomized Clinical Trial on Delay Phenomenon Utility in Preventing Oesophagogastric Anastomotic Dehiscence After Ivor-Lewis Esophagectomy. Pilot Study. Completed NCT02432794
26 Acute Kidney Injury During Daptomycin Versus Vancomycin Treatment in Cardiovascular Critically Ill Patients: a Propensity Score Matched Analysis Completed NCT03961503 Daptomycin (DAP) treatment;Vancomycin (VAN) treatment
27 Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery Completed NCT02068716
28 A Study of the Evalve® Cardiovascular Valve Repair (MitraClip®) System Endovascular Valve Edge-to-Edge REpair STudy (EVEREST II) EVEREST II High Risk Registry Completed NCT01940120
29 Management Practices and the Risk of Infection Following Cardiac Surgery Completed NCT01089712
30 Perioperative IABP in CABG Operations in Patients With Severely Depressed Left Ventricular Function: a Randomized, Controlled Trial Completed NCT00881192
31 Prospective Randomized Controlled Trial Comparing Side to Side Stapled and Hand Sewn Esophagogastric Anastomosis in the Neck Completed NCT00497549
32 Creation of a Biospecimen Repository From Patients With Interstitial Lung Diseases (ILD) Recruiting NCT03478826
33 Registry for the Improvement of Postoperative OutcomeS in Cardiac and Thoracic surgEry Recruiting NCT03209674
34 Feasibility of Transcatheter Aortic Valve Replacement in Low-Risk Patients With Symptomatic, Severe Aortic Stenosis Recruiting NCT02628899
35 Flux Measurement and Outcome in Major Abdominal Surgery Active, not recruiting NCT02612883
36 Impact of the Use of Three Dressings in the Prevention of Surgical Wound Infection in Patients Undergoing Mayor Cardiac Surgery: a Clinical Prospective and Randomized Study Not yet recruiting NCT03905213
37 Pharmacokinetics of Post Operative Cefuroxime in Infants Undergoing Cardiac Surgery Withdrawn NCT02850250 Cefuroxime

Search NIH Clinical Center for Mediastinitis

Cochrane evidence based reviews: mediastinitis

Genetic Tests for Mediastinitis

Anatomical Context for Mediastinitis

The Foundational Model of Anatomy Ontology organs/tissues related to Mediastinitis:


MalaCards organs/tissues related to Mediastinitis:

Heart, Lung, Bone, Skin, Liver, Kidney, Thyroid

Publications for Mediastinitis

Articles related to Mediastinitis:

(show top 50) (show all 3913)
# Title Authors PMID Year
The 30-Year Influence of a Regional Consortium on Quality Improvement in Cardiac Surgery. 61
31770501 2020
Treatment of esophageal perforation with mediastinal abscess by nasomediastinal drainage placement. 61
32514685 2020
Commentary: Fibrosing mediastinitis or how to give your thoracic surgeon a diagnostic migraine. 61
32562749 2020
Medical and conservative surgical management of bacterial sternoclavicular joint septic arthritis: a case series. 61
32483916 2020
Real-world evidence for increased deep neck infection risk in patients with rheumatoid arthritis. 61
31498447 2020
Staging of Surgical Procedures in Comorbid Congenital Tracheal Stenosis and Congenital Cardiovascular Disease. 61
32119856 2020
Eosinophilic esophagitis (EoE); a disease that must not be neglected - implications of esophageal rupture and its management. 61
32527222 2020
Chest Trauma Outcomes: Public Versus Private Level I Trauma Centers. 61
31993723 2020
Comparison of sonographic findings between pediatric patients with mediastinitis and without mediastinitis after cardiovascular surgery. 61
32535724 2020
Massive dilatation of the hemiazygos vein secondary to fibrosing mediastinitis. 61
32497639 2020
Mediastinitis due to perforation by a metal stent after endoscopic ultrasound-guided hepaticogastrostomy: a rare complication. 61
31816651 2020
How to perform EUS-guided hepaticogastrostomy easier and safer. 61
32511837 2020
Is nasogastric tube feeding necessary after hypopharyngeal diverticulum surgery? 61
32199712 2020
Clinical and Microbiological Analysis of Deep Sternal Wound Infections in Fifty-Two Consecutive Patients. 61
31809233 2020
A Survey of Cardiac Surgery Infections with PICO™ Negative Pressure Therapy in High-Risk Patients. 61
32371085 2020
Vomiting-induced pneumomediastinum as a result of recurrent Boerhaave's syndrome. 61
32509266 2020
Characterization of Postoperative Infection Risk in Cardiac Surgery Patients With Delayed Sternal Closure. 61
32127277 2020
Reconstruction with hypopharyngo-gastrostomy after esophagus extirpation due to spontaneous esophageal perforation. 61
32338489 2020
Negative-pressure sternal wound closure with interrupted subcuticular suturing and a subcutaneous drain tube reduces the incidence of poststernotomy wound infection after coronary artery bypass grafting surgery. 61
31705266 2020
Oesophagobronchial perforations after placement of an oesophageal self-expanding metallic stent. 61
32269776 2020
Acute mediastinitis associated with tracheobronchial tuberculosis and aspergillosis: a case report and literature review. 61
32431185 2020
Clinical Outcome of Extraanatomic Bypass for Midaortic Syndrome Caused by Takayasu Arteritis. 61
31557481 2020
Retropharyngeal Abscess. Clinical Review of Twenty-five Years. 61
32487430 2020
T4 cervical esophageal cancer cured with modern chemoradiotherapy: A case report. 61
32518786 2020
Management of Deep Sternal Wound Infection: Complete Sternal Osteomyelitis. 61
32524983 2020
Surgery for Bentall endocarditis: short- and midterm outcomes from a multicentre registry. 61
32417897 2020
Cardiac sarcoma attached to pacemaker lead. 61
32293046 2020
Fibrosing Mediastinitis Requiring Multimodality Treatment to Maintain Pulmonary Vein Patency. 61
32450211 2020
Deep Sternal Wound Infection (DSWI) and Mediastinitis After Cardiac Surgery: Current Approaches and Future Trends in Prevention and Management. 61
32215903 2020
Spontaneous community-acquired PVL-producing Staphylococcus aureus mediastinitis in an immunocompetent adult - a case report. 61
32429852 2020
Is the Obesity Paradox in Cardiac Surgery Really a Myth? Effect of Body Mass Index on Early and Late Clinical Outcomes. 61
32423731 2020
Posterior Mediastinitis Caused by Esophageal Anisakiasis. 61
32360812 2020
Staged Interventional and Surgical Treatment of Patient with Chronic Pancreatitis Complicated by Pancreaticopleural Fistula with Lung Abscesses. 61
32307403 2020
Successful Stenting of Bilateral Pulmonary Veins Stenosis Secondary to Idiopathic Fibrosing Mediastinitis. 61
32007463 2020
Emerging trends in mediastinitis: National Veterans Health Administration experience with methicillin-resistant Staphylococcus aureus prevention. 61
32386766 2020
Commentary: Mediastinitis postcoronary artery bypass grafting: From awfully simple to simply awful. 61
32336502 2020
Clinical study of an outbreak of postoperative mediastinitis caused by Serratia marcescens in adult cardiac surgery. 61
31958124 2020
A review of endovascular stenting for superior vena cava syndrome in fibrosing mediastinitis. 61
31804157 2020
Commentary: Eliminating mediastinitis in Veterans Affairs patients-the American Association for Thoracic Surgery guidelines to the rescue. 61
32336512 2020
Commentary: Mediastinitis: Know the perps-keep the lights on and adapt strategy to asymptotically approach the Centers for Medicare and Medicaid Services "never-event" status. 61
32408959 2020
A Novel Technique for the Management of Massive Hemoptysis: The Customized Endobronchial Silicone Blocker. 61
32352902 2020
Management of Nonmalignant Tracheo- and Bronchoesophageal Fistula after Esophagectomy. 61
32114691 2020
Comparison of SynCardia total artificial heart and HeartWare HVAD biventricular support for management of biventricular heart failure: a systematic review and meta-analysis. 61
32309154 2020
Fibrosing mediastinitis mimicking as chronic pulmonary thromboembolism. 61
32201604 2020
Superior vena cava stenting in IgG4-associated mediastinal fibrosis. 61
32241172 2020
[Pulmonary Adenocarcinoma Responding to Fourth-Line S-1 Monotherapy-A Case Report]. 61
32381912 2020
A Retrospective Cohort Study of Risk Factors for Descending Necrotizing Mediastinitis Caused by Multispace Infection in the Maxillofacial Region. 61
31862339 2020
Ultrasound evaluation of complications after cardiovascular surgery in pediatric patients: A case series. 61
32096798 2020
Right Ventricle Rupture After Open Heart Surgery. 61
31876539 2020
Clinical significance of the prognostic nutritional index in patients undergoing cardiovascular surgery. 61
32088837 2020

Variations for Mediastinitis

Expression for Mediastinitis

Search GEO for disease gene expression data for Mediastinitis.

Pathways for Mediastinitis

Pathways related to Mediastinitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
11.85 RPS6KB2 INS F2 DNM1
Show member pathways
3 10.57 TTR INS F2 ALB

GO Terms for Mediastinitis

Cellular components related to Mediastinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 TTR MPO INS F5 F3 F2
2 extracellular space GO:0005615 9.28 TTR MPO INS F5 F3 F2
3 endoplasmic reticulum lumen GO:0005788 9.26 INS F5 F2 ALB

Biological processes related to Mediastinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium ion export across plasma membrane GO:0036376 9.4 ATP4A ATP12A
2 cellular potassium ion homeostasis GO:0030007 9.37 ATP4A ATP12A
3 hemostasis GO:0007599 9.33 F5 F3 F2
4 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.32 ATP4A ATP12A
5 negative regulation of blood vessel diameter GO:0097756 9.26 INS CRP
6 acute-phase response GO:0006953 9.13 INS F2 CRP
7 cellular protein metabolic process GO:0044267 9.02 TTR INS F5 F2 ALB

Molecular functions related to Mediastinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Mediastinitis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
Loading form....