MCID: MDS002
MIFTS: 29

Mediastinum Liposarcoma

Categories: Cancer diseases

Aliases & Classifications for Mediastinum Liposarcoma

MalaCards integrated aliases for Mediastinum Liposarcoma:

Name: Mediastinum Liposarcoma 12 15
Liposarcoma of Mediastinum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5713
NCIt 49 C6614
UMLS 71 C1334663

Summaries for Mediastinum Liposarcoma

Disease Ontology : 12 A liposarcoma that is located in the mediastinum.

MalaCards based summary : Mediastinum Liposarcoma, also known as liposarcoma of mediastinum, is related to gastric liposarcoma and myxoid liposarcoma. An important gene associated with Mediastinum Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are ERK Signaling and Cell Cycle, Mitotic. Affiliated tissues include mediastinum, breast and lung, and related phenotypes are Decreased cella89culturea89derived Hepatitis C virus (HCVcc; Luca89Jc1) infection and Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection

Related Diseases for Mediastinum Liposarcoma

Diseases related to Mediastinum Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 gastric liposarcoma 30.0 MDM2 CDK4
2 myxoid liposarcoma 29.9 MDM2 CDK4
3 liposarcoma 29.5 MDM2 CDKN2A CDK4
4 well-differentiated liposarcoma 29.1 MDM2 CDKN2A CDK4
5 dedifferentiated liposarcoma 29.1 MDM2 CDKN2A CDK4
6 maxillary sinus adenocarcinoma 10.1 MDM2 ATM
7 ring chromosome 7 10.0 MDM2 CDK4
8 ring chromosome 10.0 MDM2 CDK4
9 diffuse lipomatosis 10.0 MDM2 CDK4
10 undifferentiated embryonal sarcoma of the liver 10.0 MDM2 CDK4
11 embryonal sarcoma 10.0 MDM2 CDK4
12 spindle cell liposarcoma 10.0 MDM2 CDK4
13 pediatric liposarcoma 10.0 MDM2 CDK4
14 malignant mesenchymoma 10.0
15 infiltrating lipoma 10.0 MDM2 CDK4
16 lipoblastoma 10.0 MDM2 CDK4
17 liposarcoma of bone 10.0 MDM2 CDK4
18 inflammatory mfh 10.0 MDM2 CDK4
19 angiomyolipoma 10.0
20 pancreas sarcoma 10.0 MDM2 CDK4
21 adult liposarcoma 10.0 MDM2 CDK4
22 juxtacortical osteosarcoma 10.0 MDM2 CDK4
23 paratesticular lipoma 10.0 MDM2 CDK4
24 lipoma of spermatic cord 10.0 MDM2 CDK4
25 pleomorphic lipoma 10.0 MDM2 CDK4
26 peripheral osteosarcoma 10.0 MDM2 CDK4
27 extraosseous osteosarcoma 10.0 MDM2 CDK4
28 mixed liposarcoma 10.0 MDM2 CDK4
29 retroperitoneal sarcoma 10.0 MDM2 CDK4
30 parameningeal embryonal rhabdomyosarcoma 10.0 MDM2 CDK4
31 embryonal rhabdomyosarcoma 9.9 MDM2 CDK4
32 cellular myxoid liposarcoma 9.9 MDM2 CDK4
33 bone osteosarcoma 9.9 MDM2 CDK4
34 connective tissue benign neoplasm 9.9 MDM2 CDK4
35 lipomatosis, multiple 9.9 MDM2 CDK4
36 malignant fibroxanthoma 9.9 MDM2 CDK4
37 heart leiomyosarcoma 9.8 MDM2 CDKN2A
38 esophagus verrucous carcinoma 9.8 MDM2 CDKN2A
39 verrucous carcinoma 9.8 MDM2 CDKN2A
40 inflammatory liposarcoma 9.8 MDM2 CDKN2A
41 muscle cancer 9.8 MDM2 CDK4
42 rhabdomyosarcoma 2 9.8 MDM2 CDK4
43 inflammatory myofibroblastic tumor 9.8 MDM2 CDK4
44 urethra clear cell adenocarcinoma 9.8 CDKN2A ATM
45 anal squamous cell carcinoma 9.8 MDM2 CDKN2A
46 gliomatosis cerebri 9.8 MDM2 CDKN2A
47 bilateral breast cancer 9.7 CDKN2A ATM
48 nodular malignant melanoma 9.7 CDKN2A CDK4
49 dysplastic nevus syndrome 9.7 CDKN2A CDK4
50 giant cell glioblastoma 9.7 MDM2 CDKN2A

Graphical network of the top 20 diseases related to Mediastinum Liposarcoma:



Diseases related to Mediastinum Liposarcoma

Symptoms & Phenotypes for Mediastinum Liposarcoma

GenomeRNAi Phenotypes related to Mediastinum Liposarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cella89culturea89derived Hepatitis C virus (HCVcc; Luca89Jc1) infection GR00234-A-2 9.16 ATM CDK4
2 Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection GR00234-A-1 8.96 ATM CDK4
3 Decreased viability after gemcitabine stimulation GR00107-A-2 8.62 ATM CDKN2A

MGI Mouse Phenotypes related to Mediastinum Liposarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.67 ATM CDK4 CDKN2A MDM2
2 endocrine/exocrine gland MP:0005379 9.62 ATM CDK4 CDKN2A MDM2
3 integument MP:0010771 9.56 ATM CDK4 CDKN2A MDM2
4 neoplasm MP:0002006 9.46 ATM CDK4 CDKN2A MDM2
5 pigmentation MP:0001186 9.13 CDK4 CDKN2A MDM2
6 reproductive system MP:0005389 8.92 ATM CDK4 CDKN2A MDM2

Drugs & Therapeutics for Mediastinum Liposarcoma

Search Clinical Trials , NIH Clinical Center for Mediastinum Liposarcoma

Genetic Tests for Mediastinum Liposarcoma

Anatomical Context for Mediastinum Liposarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Mediastinum Liposarcoma:

19
Mediastinum

MalaCards organs/tissues related to Mediastinum Liposarcoma:

40
Breast, Lung, Bone, B Cells, Eye, Heart, Liver

Publications for Mediastinum Liposarcoma

Articles related to Mediastinum Liposarcoma:

# Title Authors PMID Year
1
Resection of a huge mediastinal well-differentiated liposarcoma involving left thoracic cavity. 61
31387607 2019
2
Recurrent dedifferentiated liposarcoma of mediastinum involving lung and pleura. 61
19589790 2009
3
Aggressive myxoid liposarcoma of mediastinum. 61
1481314 1992

Variations for Mediastinum Liposarcoma

Expression for Mediastinum Liposarcoma

Search GEO for disease gene expression data for Mediastinum Liposarcoma.

Pathways for Mediastinum Liposarcoma

Pathways related to Mediastinum Liposarcoma according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 MDM2 CDKN2A CDK4 ATM
2
Show member pathways
13.1 MDM2 CDKN2A CDK4 ATM
3
Show member pathways
12.83 MDM2 CDKN2A CDK4 ATM
4
Show member pathways
12.69 MDM2 CDK4 ATM
5
Show member pathways
12.66 MDM2 CDKN2A ATM
6
Show member pathways
12.64 MDM2 CDKN2A CDK4 ATM
7
Show member pathways
12.58 MDM2 CDKN2A CDK4
8 12.56 MDM2 CDKN2A CDK4
9
Show member pathways
12.53 MDM2 CDKN2A ATM
10
Show member pathways
12.43 MDM2 CDK4 ATM
11
Show member pathways
12.37 MDM2 CDKN2A CDK4 ATM
12 12.29 MDM2 CDKN2A ATM
13
Show member pathways
12.28 MDM2 CDKN2A CDK4 ATM
14
Show member pathways
12.14 CDKN2A CDK4 ATM
15 12.14 MDM2 CDKN2A CDK4 ATM
16 12.12 CDKN2A CDK4 ATM
17 12.08 MDM2 CDKN2A CDK4
18
Show member pathways
12.04 MDM2 CDK4 ATM
19 11.93 MDM2 CDK4 ATM
20
Show member pathways
11.93 MDM2 CDKN2A CDK4 ATM
21
Show member pathways
11.82 MDM2 ATM
22 11.82 MDM2 CDKN2A CDK4 ATM
23 11.79 MDM2 CDKN2A ATM
24 11.76 MDM2 CDKN2A CDK4
25 11.71 MDM2 CDKN2A
26 11.62 MDM2 CDK4
27
Show member pathways
11.61 MDM2 ATM
28
Show member pathways
11.56 MDM2 CDKN2A ATM
29 11.55 MDM2 CDKN2A ATM
30 11.53 MDM2 CDKN2A CDK4
31 11.48 MDM2 CDKN2A ATM
32 11.43 MDM2 ATM
33 11.38 MDM2 CDKN2A
34 11.27 MDM2 CDK4 ATM
35 11.22 MDM2 CDK4 ATM
36 11.14 CDK4 ATM
37 11.13 CDK4 ATM
38 11.13 MDM2 CDKN2A CDK4 ATM
39 11 MDM2 CDKN2A CDK4
40 10.96 MDM2 CDKN2A
41
Show member pathways
10.47 MDM2 CDKN2A ATM

GO Terms for Mediastinum Liposarcoma

Cellular components related to Mediastinum Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleolus GO:0005730 8.92 MDM2 CDKN2A CDK4 ATM

Biological processes related to Mediastinum Liposarcoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.71 CDKN2A CDK4 ATM
2 cell cycle GO:0007049 9.7 CDKN2A CDK4 ATM
3 positive regulation of gene expression GO:0010628 9.63 MDM2 CDKN2A ATM
4 cell cycle arrest GO:0007050 9.58 CDKN2A ATM
5 regulation of signal transduction by p53 class mediator GO:1901796 9.57 MDM2 ATM
6 response to toxic substance GO:0009636 9.56 MDM2 CDK4
7 G1/S transition of mitotic cell cycle GO:0000082 9.55 CDKN2A CDK4
8 positive regulation of apoptotic process GO:0043065 9.54 CDKN2A CDK4 ATM
9 protein sumoylation GO:0016925 9.51 MDM2 CDKN2A
10 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.49 CDKN2A CDK4
11 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.48 MDM2 ATM
12 protein destabilization GO:0031648 9.43 MDM2 CDKN2A
13 positive regulation of cell cycle GO:0045787 9.4 MDM2 CDK4
14 cellular response to gamma radiation GO:0071480 9.32 MDM2 ATM
15 negative regulation of cell cycle arrest GO:0071157 9.26 MDM2 CDK4
16 negative regulation of B cell proliferation GO:0030889 9.16 CDKN2A ATM
17 replicative senescence GO:0090399 8.96 CDKN2A ATM
18 amyloid fibril formation GO:1990000 8.62 MDM2 CDKN2A

Molecular functions related to Mediastinum Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.33 CDKN2A CDK4 ATM
2 protein N-terminus binding GO:0047485 9.26 MDM2 ATM
3 disordered domain specific binding GO:0097718 8.96 MDM2 CDKN2A
4 SUMO transferase activity GO:0019789 8.62 MDM2 CDKN2A

Sources for Mediastinum Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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