MCID: MDS002
MIFTS: 26

Mediastinum Liposarcoma

Categories: Cancer diseases

Aliases & Classifications for Mediastinum Liposarcoma

MalaCards integrated aliases for Mediastinum Liposarcoma:

Name: Mediastinum Liposarcoma 12 15
Liposarcoma of Mediastinum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5713
NCIt 50 C6614
UMLS 72 C1334663

Summaries for Mediastinum Liposarcoma

Disease Ontology : 12 A liposarcoma that is located in the mediastinum.

MalaCards based summary : Mediastinum Liposarcoma, also known as liposarcoma of mediastinum, is related to liposarcoma and myxoid liposarcoma. An important gene associated with Mediastinum Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Cell Cycle, Mitotic and Cellular Senescence (REACTOME). Affiliated tissues include lung and mediastinum, and related phenotypes are digestive/alimentary and liver/biliary system

Related Diseases for Mediastinum Liposarcoma

Diseases related to Mediastinum Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 liposarcoma 29.7 MDM2 CDKN2A CDK4
2 myxoid liposarcoma 29.6 MDM2 CDK4
3 malignant mesenchymoma 29.5 MDM2 CDK4
4 dedifferentiated liposarcoma 29.0 MDM2 CDKN2A CDK4
5 pleomorphic liposarcoma 10.0 MDM2 CDKN2A
6 verrucous carcinoma 10.0 MDM2 CDKN2A
7 gastric liposarcoma 10.0
8 angiomyolipoma 10.0
9 cellular schwannoma 10.0 MDM2 CDKN2A
10 cerebrum cancer 9.9 MDM2 CDKN2A
11 supratentorial cancer 9.9 MDM2 CDKN2A
12 skin melanoma 9.9 MDM2 CDKN2A
13 cornea cancer 9.9 CDKN2A CDK4
14 ewing's family of tumors 9.8 CDKN2A CDK4
15 ring chromosome 7 9.8 MDM2 CDK4
16 salivary gland carcinoma 9.8 MDM2 CDKN2A
17 undifferentiated embryonal sarcoma of the liver 9.8 MDM2 CDK4
18 embryonal sarcoma 9.8 MDM2 CDK4
19 spindle cell lipoma 9.8 MDM2 CDK4
20 inflammatory mfh 9.8 MDM2 CDK4
21 cellular myxoid liposarcoma 9.8 MDM2 CDK4
22 lipoblastoma 9.8 MDM2 CDK4
23 bone osteosarcoma 9.8 MDM2 CDK4
24 malignant fibrous histiocytoma of bone 9.8 MDM2 CDK4
25 mixed liposarcoma 9.8 MDM2 CDK4
26 chondroid lipoma 9.7 MDM2 CDK4
27 periosteal osteogenic sarcoma 9.7 MDM2 CDK4
28 spindle cell liposarcoma 9.7 MDM2 CDK4
29 infiltrating lipoma 9.7 MDM2 CDK4
30 small cell sarcoma 9.7 MDM2 CDK4
31 li-fraumeni syndrome 9.7 MDM2 CDKN2A
32 juxtacortical osteosarcoma 9.7 MDM2 CDK4
33 peripheral osteosarcoma 9.7 MDM2 CDK4
34 lipomatosis, multiple 9.7 MDM2 CDK4
35 malignant fibroxanthoma 9.7 MDM2 CDK4
36 connective tissue cancer 9.7 MDM2 CDK4
37 rhabdomyosarcoma 2 9.6 MDM2 CDK4
38 rhabdomyosarcoma 9.6 MDM2 CDK4
39 inflammatory myofibroblastic tumor 9.5 MDM2 CDK4
40 leiomyosarcoma 9.5 MDM2 CDK4
41 melanoma, uveal 9.5 CDKN2A CDK4
42 myeloma, multiple 9.5 CDKN2A CDK4
43 infiltrating angiolipoma 9.3 MDM2 CDKN2A CDK4
44 periosteal chondrosarcoma 9.3 MDM2 CDKN2A CDK4
45 ischemic fasciitis 9.3 MDM2 CDKN2A CDK4
46 well-differentiated liposarcoma 9.3 MDM2 CDKN2A CDK4
47 fibrosarcoma of bone 9.3 MDM2 CDKN2A CDK4
48 retinal cancer 9.3 MDM2 CDKN2A CDK4
49 ocular cancer 9.3 MDM2 CDKN2A CDK4
50 grade iii astrocytoma 9.3 MDM2 CDKN2A CDK4

Graphical network of the top 20 diseases related to Mediastinum Liposarcoma:



Diseases related to Mediastinum Liposarcoma

Symptoms & Phenotypes for Mediastinum Liposarcoma

MGI Mouse Phenotypes related to Mediastinum Liposarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 CDK4 CDKN2A MDM2
2 liver/biliary system MP:0005370 9.43 CDK4 CDKN2A MDM2
3 muscle MP:0005369 9.33 CDK4 CDKN2A MDM2
4 neoplasm MP:0002006 9.13 CDK4 CDKN2A MDM2
5 pigmentation MP:0001186 8.8 CDK4 CDKN2A MDM2

Drugs & Therapeutics for Mediastinum Liposarcoma

Search Clinical Trials , NIH Clinical Center for Mediastinum Liposarcoma

Genetic Tests for Mediastinum Liposarcoma

Anatomical Context for Mediastinum Liposarcoma

MalaCards organs/tissues related to Mediastinum Liposarcoma:

41
Lung

The Foundational Model of Anatomy Ontology organs/tissues related to Mediastinum Liposarcoma:

19
Mediastinum

Publications for Mediastinum Liposarcoma

Articles related to Mediastinum Liposarcoma:

# Title Authors PMID Year
1
Resection of a huge mediastinal well-differentiated liposarcoma involving left thoracic cavity. 38
31387607 2019
2
Recurrent dedifferentiated liposarcoma of mediastinum involving lung and pleura. 38
19589790 2009
3
Aggressive myxoid liposarcoma of mediastinum. 38
1481314 1992

Variations for Mediastinum Liposarcoma

Expression for Mediastinum Liposarcoma

Search GEO for disease gene expression data for Mediastinum Liposarcoma.

Pathways for Mediastinum Liposarcoma

Pathways related to Mediastinum Liposarcoma according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 MDM2 CDKN2A CDK4
2
Show member pathways
12.73 MDM2 CDKN2A CDK4
3
Show member pathways
12.56 MDM2 CDKN2A CDK4
4
Show member pathways
12.48 MDM2 CDKN2A CDK4
5 12.42 MDM2 CDKN2A CDK4
6
Show member pathways
12.28 MDM2 CDKN2A CDK4
7
Show member pathways
12.15 MDM2 CDKN2A CDK4
8 12.08 MDM2 CDKN2A CDK4
9
Show member pathways
12 CDKN2A CDK4
10
Show member pathways
11.95 MDM2 CDKN2A CDK4
11
Show member pathways
11.9 MDM2 CDK4
12 11.9 MDM2 CDKN2A CDK4
13
Show member pathways
11.89 CDKN2A CDK4
14 11.81 MDM2 CDK4
15 11.8 MDM2 CDK4
16 11.8 MDM2 CDKN2A CDK4
17 11.72 MDM2 CDKN2A
18 11.68 MDM2 CDKN2A
19 11.64 MDM2 CDKN2A
20 11.64 MDM2 CDKN2A CDK4
21 11.54 MDM2 CDK4
22
Show member pathways
11.45 MDM2 CDKN2A
23 11.44 MDM2 CDKN2A
24 11.38 MDM2 CDKN2A CDK4
25 11.37 MDM2 CDKN2A
26 11.3 MDM2 CDKN2A
27 11.21 MDM2 CDK4
28 11.18 MDM2 CDK4
29 11 MDM2 CDKN2A CDK4
30
Show member pathways
10.84 MDM2 CDKN2A
31 10.82 MDM2 CDKN2A
32 10.3 MDM2 CDKN2A CDK4

GO Terms for Mediastinum Liposarcoma

Cellular components related to Mediastinum Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleolus GO:0005730 8.8 MDM2 CDKN2A CDK4

Biological processes related to Mediastinum Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.43 MDM2 CDK4
2 response to toxic substance GO:0009636 9.4 MDM2 CDK4
3 G1/S transition of mitotic cell cycle GO:0000082 9.37 CDKN2A CDK4
4 positive regulation of cell cycle GO:0045787 9.32 MDM2 CDK4
5 protein destabilization GO:0031648 9.26 MDM2 CDKN2A
6 protein sumoylation GO:0016925 9.16 MDM2 CDKN2A
7 negative regulation of cell cycle arrest GO:0071157 8.96 MDM2 CDK4
8 amyloid fibril formation GO:1990000 8.62 MDM2 CDKN2A

Molecular functions related to Mediastinum Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.96 MDM2 CDKN2A
2 SUMO transferase activity GO:0019789 8.62 MDM2 CDKN2A

Sources for Mediastinum Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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