MCID: MDS023
MIFTS: 30

Mediastinum Sarcoma

Categories: Cancer diseases

Aliases & Classifications for Mediastinum Sarcoma

MalaCards integrated aliases for Mediastinum Sarcoma:

Name: Mediastinum Sarcoma 12 15
Sarcoma of Mediastinum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4050
NCIt 50 C6606
UMLS 72 C1334678

Summaries for Mediastinum Sarcoma

Disease Ontology : 12 A sarcoma and malignant mediastinal mesenchymnal tumor that is located in the mediastinum.

MalaCards based summary : Mediastinum Sarcoma, also known as sarcoma of mediastinum, is related to mediastinum synovial sarcoma and pleomorphic liposarcoma. An important gene associated with Mediastinum Sarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Cell Cycle, Mitotic and Cellular Senescence (REACTOME). The drugs Celecoxib and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include lung and mediastinum, and related phenotypes are digestive/alimentary and liver/biliary system

Related Diseases for Mediastinum Sarcoma

Diseases related to Mediastinum Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 mediastinum synovial sarcoma 11.4
2 pleomorphic liposarcoma 10.0 MDM2 CDKN2A
3 sarcoma 10.0
4 spindle cell sarcoma 10.0
5 verrucous carcinoma 10.0 MDM2 CDKN2A
6 cellular schwannoma 10.0 MDM2 CDKN2A
7 cerebrum cancer 9.9 MDM2 CDKN2A
8 supratentorial cancer 9.9 MDM2 CDKN2A
9 skin melanoma 9.9 MDM2 CDKN2A
10 cornea cancer 9.9 CDKN2A CDK4
11 leukemia, acute myeloid 9.9
12 leukemia, chronic myeloid 9.9
13 myelodysplastic syndrome 9.9
14 follicular dendritic cell sarcoma 9.9
15 myeloid sarcoma 9.9
16 myeloid leukemia 9.9
17 soft tissue sarcoma 9.9
18 ewing's family of tumors 9.8 CDKN2A CDK4
19 ring chromosome 7 9.8 MDM2 CDK4
20 salivary gland carcinoma 9.8 MDM2 CDKN2A
21 undifferentiated embryonal sarcoma of the liver 9.8 MDM2 CDK4
22 embryonal sarcoma 9.8 MDM2 CDK4
23 spindle cell lipoma 9.8 MDM2 CDK4
24 inflammatory mfh 9.8 MDM2 CDK4
25 cellular myxoid liposarcoma 9.8 MDM2 CDK4
26 myxoid liposarcoma 9.8 MDM2 CDK4
27 lipoblastoma 9.8 MDM2 CDK4
28 bone osteosarcoma 9.8 MDM2 CDK4
29 malignant fibrous histiocytoma of bone 9.8 MDM2 CDK4
30 mixed liposarcoma 9.8 MDM2 CDK4
31 chondroid lipoma 9.7 MDM2 CDK4
32 periosteal osteogenic sarcoma 9.7 MDM2 CDK4
33 spindle cell liposarcoma 9.7 MDM2 CDK4
34 infiltrating lipoma 9.7 MDM2 CDK4
35 small cell sarcoma 9.7 MDM2 CDK4
36 li-fraumeni syndrome 9.7 MDM2 CDKN2A
37 juxtacortical osteosarcoma 9.7 MDM2 CDK4
38 peripheral osteosarcoma 9.7 MDM2 CDK4
39 lipomatosis, multiple 9.7 MDM2 CDK4
40 malignant fibroxanthoma 9.7 MDM2 CDK4
41 malignant mesenchymoma 9.7 MDM2 CDK4
42 connective tissue cancer 9.7 MDM2 CDK4
43 rhabdomyosarcoma 2 9.6 MDM2 CDK4
44 rhabdomyosarcoma 9.6 MDM2 CDK4
45 inflammatory myofibroblastic tumor 9.5 MDM2 CDK4
46 leiomyosarcoma 9.5 MDM2 CDK4
47 melanoma, uveal 9.5 CDKN2A CDK4
48 myeloma, multiple 9.5 CDKN2A CDK4
49 infiltrating angiolipoma 9.3 MDM2 CDKN2A CDK4
50 periosteal chondrosarcoma 9.3 MDM2 CDKN2A CDK4

Graphical network of the top 20 diseases related to Mediastinum Sarcoma:



Diseases related to Mediastinum Sarcoma

Symptoms & Phenotypes for Mediastinum Sarcoma

MGI Mouse Phenotypes related to Mediastinum Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 CDK4 CDKN2A MDM2
2 liver/biliary system MP:0005370 9.43 CDK4 CDKN2A MDM2
3 muscle MP:0005369 9.33 CDK4 CDKN2A MDM2
4 neoplasm MP:0002006 9.13 CDK4 CDKN2A MDM2
5 pigmentation MP:0001186 8.8 CDK4 CDKN2A MDM2

Drugs & Therapeutics for Mediastinum Sarcoma

Drugs for Mediastinum Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Celecoxib Approved, Investigational Phase 1, Phase 2 169590-42-5 2662
2
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
3 Analgesics Phase 1, Phase 2
4 Cyclooxygenase Inhibitors Phase 1, Phase 2
5 Vaccines Phase 1, Phase 2
6 Alkylating Agents Phase 1, Phase 2
7 Cyclooxygenase 2 Inhibitors Phase 1, Phase 2
8 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
9 Immunologic Factors Phase 1, Phase 2
10 Peripheral Nervous System Agents Phase 1, Phase 2
11 Analgesics, Non-Narcotic Phase 1, Phase 2
12 Immunosuppressive Agents Phase 1, Phase 2
13 Anti-Inflammatory Agents Phase 1, Phase 2
14 Antineoplastic Agents, Alkylating Phase 1, Phase 2
15 Antirheumatic Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Adjuvant Tumor Lysate Vaccine and Iscomatrix With or Without Metronomic Oral Cyclophosphamide and Celecoxib in Patients With Malignancies Involving Lungs, Esophagus, Pleura, or Mediastinum Suspended NCT02054104 Phase 1, Phase 2 Cyclophosphamide;Celecoxib

Search NIH Clinical Center for Mediastinum Sarcoma

Genetic Tests for Mediastinum Sarcoma

Anatomical Context for Mediastinum Sarcoma

MalaCards organs/tissues related to Mediastinum Sarcoma:

41
Lung

The Foundational Model of Anatomy Ontology organs/tissues related to Mediastinum Sarcoma:

19
Mediastinum

Publications for Mediastinum Sarcoma

Articles related to Mediastinum Sarcoma:

# Title Authors PMID Year
1
Follicular dendritic cell sarcoma of mediastinum: a key role of radiotherapy in a multidisciplinary approach. 38
26638926 2015
2
[Primary soft tissue sarcomas of mediastinum: experience in 22 cases from a single institution]. 38
18642788 2008
3
Myelodysplasia presenting as granulocytic sarcoma of mediastinum causing superior vena cava syndrome. 38
10784409 2000

Variations for Mediastinum Sarcoma

Expression for Mediastinum Sarcoma

Search GEO for disease gene expression data for Mediastinum Sarcoma.

Pathways for Mediastinum Sarcoma

Pathways related to Mediastinum Sarcoma according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 MDM2 CDKN2A CDK4
2
Show member pathways
12.73 MDM2 CDKN2A CDK4
3
Show member pathways
12.56 MDM2 CDKN2A CDK4
4
Show member pathways
12.48 MDM2 CDKN2A CDK4
5 12.42 MDM2 CDKN2A CDK4
6
Show member pathways
12.28 MDM2 CDKN2A CDK4
7
Show member pathways
12.15 MDM2 CDKN2A CDK4
8 12.08 MDM2 CDKN2A CDK4
9
Show member pathways
12 CDKN2A CDK4
10
Show member pathways
11.95 MDM2 CDKN2A CDK4
11
Show member pathways
11.9 MDM2 CDK4
12 11.9 MDM2 CDKN2A CDK4
13
Show member pathways
11.89 CDKN2A CDK4
14 11.81 MDM2 CDK4
15 11.8 MDM2 CDK4
16 11.8 MDM2 CDKN2A CDK4
17 11.72 MDM2 CDKN2A
18 11.68 MDM2 CDKN2A
19 11.64 MDM2 CDKN2A
20 11.64 MDM2 CDKN2A CDK4
21 11.54 MDM2 CDK4
22
Show member pathways
11.45 MDM2 CDKN2A
23 11.44 MDM2 CDKN2A
24 11.38 MDM2 CDKN2A CDK4
25 11.37 MDM2 CDKN2A
26 11.3 MDM2 CDKN2A
27 11.21 MDM2 CDK4
28 11.18 MDM2 CDK4
29 11 MDM2 CDKN2A CDK4
30
Show member pathways
10.84 MDM2 CDKN2A
31 10.82 MDM2 CDKN2A
32 10.3 MDM2 CDKN2A CDK4

GO Terms for Mediastinum Sarcoma

Cellular components related to Mediastinum Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleolus GO:0005730 8.8 MDM2 CDKN2A CDK4

Biological processes related to Mediastinum Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.43 MDM2 CDK4
2 response to toxic substance GO:0009636 9.4 MDM2 CDK4
3 G1/S transition of mitotic cell cycle GO:0000082 9.37 CDKN2A CDK4
4 positive regulation of cell cycle GO:0045787 9.32 MDM2 CDK4
5 protein destabilization GO:0031648 9.26 MDM2 CDKN2A
6 protein sumoylation GO:0016925 9.16 MDM2 CDKN2A
7 negative regulation of cell cycle arrest GO:0071157 8.96 MDM2 CDK4
8 amyloid fibril formation GO:1990000 8.62 MDM2 CDKN2A

Molecular functions related to Mediastinum Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.96 MDM2 CDKN2A
2 SUMO transferase activity GO:0019789 8.62 MDM2 CDKN2A

Sources for Mediastinum Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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