Mediastinum Sarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Mediastinum Sarcoma

MalaCards integrated aliases for Mediastinum Sarcoma:

Name: Mediastinum Sarcoma ¹² ¹⁵

Sarcoma of Mediastinum ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4050

NCIt ⁴⁹ C6606

UMLS ⁷¹ C1334678

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Summaries for Mediastinum Sarcoma

Disease Ontology : ¹² A sarcoma and malignant mediastinal mesenchymnal tumor that is located in the mediastinum.

MalaCards based summary : Mediastinum Sarcoma, also known as sarcoma of mediastinum, is related to spindle cell sarcoma and myeloid sarcoma. An important gene associated with Mediastinum Sarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Human cytomegalovirus infection and Glioma. The drugs Celecoxib and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include mediastinum, lung and myeloid, and related phenotypes are Reduced mammosphere formation and cellular

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Related Diseases for Mediastinum Sarcoma

Diseases related to Mediastinum Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 277)

#	Related Disease	Score	Top Affiliating Genes
1	spindle cell sarcoma	30.2	MDM2 KRT7
2	myeloid sarcoma	29.2	NCAM1 CD68
3	leukemia, acute myeloid	28.7	NCAM1 MDM2 CDKN2A CDK4 ATM
4	myelodysplastic syndrome	28.5	MDM2 CDKN2A CDK4 CD68 ATM
5	mediastinum synovial sarcoma	11.4
6	ring chromosome 7	10.4	MDM2 CDK4
7	ring chromosome	10.4	MDM2 CDK4
8	gastric liposarcoma	10.4	MDM2 CDK4
9	diffuse lipomatosis	10.4	MDM2 CDK4
10	undifferentiated embryonal sarcoma of the liver	10.4	MDM2 CDK4
11	embryonal sarcoma	10.4	MDM2 CDK4
12	spindle cell liposarcoma	10.4	MDM2 CDK4
13	pediatric liposarcoma	10.4	MDM2 CDK4
14	infiltrating lipoma	10.4	MDM2 CDK4
15	lipoblastoma	10.4	MDM2 CDK4
16	liposarcoma of bone	10.4	MDM2 CDK4
17	adult liposarcoma	10.4	MDM2 CDK4
18	juxtacortical osteosarcoma	10.4	MDM2 CDK4
19	pleomorphic lipoma	10.4	MDM2 CDK4
20	esophagus verrucous carcinoma	10.4	MDM2 CDKN2A
21	verrucous carcinoma	10.4	MDM2 CDKN2A
22	peripheral osteosarcoma	10.4	MDM2 CDK4
23	inflammatory liposarcoma	10.4	MDM2 CDKN2A
24	mixed liposarcoma	10.4	MDM2 CDK4
25	parameningeal embryonal rhabdomyosarcoma	10.4	MDM2 CDK4
26	cellular myxoid liposarcoma	10.4	MDM2 CDK4
27	peritoneal mesothelioma	10.3	CDKN2A CALB2
28	anal squamous cell carcinoma	10.3	MDM2 CDKN2A
29	nodular malignant melanoma	10.3	CDKN2A CDK4
30	aortic malignant tumor	10.3	MDM2 KRT7
31	bone osteosarcoma	10.3	MDM2 CDK4
32	fallopian tube endometrioid adenocarcinoma	10.3	CDKN2A CALB2
33	dysplastic nevus syndrome	10.3	CDKN2A CDK4
34	maxillary sinus adenocarcinoma	10.3	MDM2 ATM
35	cervical basaloid squamous cell carcinoma	10.3	KRT7 CDKN2A
36	inverted transitional papilloma	10.3	KRT7 CDKN2A
37	endometrial transitional cell carcinoma	10.2	KRT7 CDKN2A
38	anal canal paget's disease	10.2	KRT7 CDKN2A
39	anus basaloid carcinoma	10.2	KRT7 CDKN2A
40	cervical adenoid cystic carcinoma	10.2	KRT7 CDKN2A
41	atrophic vulva	10.2	KRT7 CDKN2A
42	hydrocele	10.2	KRT19 CALB2
43	gliomatosis cerebri	10.2	MDM2 CDKN2A
44	cystadenofibroma	10.2	KRT7 CALB2
45	ovarian seromucinous carcinoma	10.2	KRT7 CDKN2A
46	vaginal tubulovillous adenoma	10.2	KRT7 CDKN2A
47	pericardial mesothelioma	10.2	KRT19 CALB2
48	vaginal adenoma	10.2	KRT7 CDKN2A
49	vaginal benign neoplasm	10.2	KRT7 CDKN2A
50	cholangiolocellular carcinoma	10.2	KRT19 CDKN2A

Graphical network of the top 20 diseases related to Mediastinum Sarcoma:

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Symptoms & Phenotypes for Mediastinum Sarcoma

GenomeRNAi Phenotypes related to Mediastinum Sarcoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.02	ATM CDK4 KRT7 MDM2 NCAM1

MGI Mouse Phenotypes related to Mediastinum Sarcoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	9.7	ATM CDK4 CDKN2A KRT19 KRT7 MDM2
2	neoplasm	MP:0002006	9.35	ATM CDK4 CDKN2A KRT19 MDM2
3	nervous system	MP:0003631	9.17	ATM CALB2 CDK4 CDKN2A KRT19 MDM2

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Drugs & Therapeutics for Mediastinum Sarcoma

Drugs for Mediastinum Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Celecoxib

Approved, Investigational

Phase 1, Phase 2

169590-42-5

2662

Synonyms:

169590-42-5

184007-95-2

1oq5

4-(5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1Hpyrazol-1-yl] benzenesulfonamide

4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE

4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide

AC1L1E6K

AC-4228

AI-525

Benzenesulfonamide,4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)

BIDD:GT0408

BRD-K02637541-001-02-4

BSPBio_003596

C07589

C105934

C17H14F3N3O2S

CCRIS 8679

CEL

Celebra

Celebrex

Celebrex (TN)

Celebrex, Celebra, Celecoxib

Celecox

Celecoxi

celecoxib

Celecoxib

Célécoxib

Celecoxib (JAN/USAN/INN)

Celecoxib (SC-58635)

Celecoxib [Old RN]

Celecoxib [USAN]

Celecoxibum

Celocoxib

CEP-33222

CHEBI:41423

CHEMBL118

CID2662

cMAP_000027

CPD000550473

D00567

DB00482

DivK1c_000893

Eurocox

FT-0080064

HMS1922G14

HMS2089L18

HMS2093I07

HMS502M15

HSDB 7038

I01-1033

IDI1_000893

KBio1_000893

KBio2_000912

KBio2_002351

KBio2_003480

KBio2_004919

KBio2_006048

KBio2_007487

KBio3_002830

KBio3_003037

KBioGR_000723

KBioGR_002351

KBioSS_000912

KBioSS_002354

LS-31667

Medicoxib

MLS001165684

MLS001195656

MLS001304708

MolPort-002-885-815

NCGC00091455-01

NCGC00091455-02

NCGC00091455-03

NCGC00091455-04

NCI60_041049

NINDS_000893

NSC719627

Onsenal

p-(5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide

P-(5-P-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide

P-(5-P-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulphonamide

Pfizer brand of celecoxib

S1261_Selleck

SAM002589995

SC 58635

SC-58553, SC-58635

SC58635

SC-58635

SMR000550473

Solexa

SPBio_001512

Spectrum_000432

SPECTRUM1503678

Spectrum2_001576

Spectrum3_001996

Spectrum4_000182

Spectrum5_001324

TL8001323

TPI-336

UNM-0000305813

Xilebao

YM 177

YM177

YM-177

ZINC02570895

2

Cyclophosphamide

Approved, Investigational

Phase 1, Phase 2

50-18-0, 6055-19-2

2907

Synonyms:

(-)-Cyclophosphamide

(+-)-Cyclophosphamide

(RS)-Cyclophosphamide

1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine

1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin

2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide

4-Hydroxy-cyclophosphan-mamophosphatide

50-18-0

60007-95-6

6055-19-2 (monohydrate)

75526-90-8

AC1L1EQQ

AI3-26198

Anhydrous cyclophosphamide

Anhydrous, cyclophosphamide

ASTA

Asta B 518

ASTA B518

B 518

B-518

bis(2-Chloroethyl)phosphami de cyclic propanolamide

bis(2-Chloroethyl)phosphamide cyclic propanolamide ester

Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester

BRN 0011744

BSPBio_002099

C 0768

C07888

C7H15Cl2N2O2P

CB 4564

CB-4564

CCRIS 188

CHEBI:4027

CHEMBL32520

CHEMBL88

Ciclofosfamida

Ciclofosfamida [INN-Spanish]

Ciclofosfamide

Ciclophosphamide

Ciclophosphamide [INN]

CID2907

Clafen

Claphene

CP

CPA

CTX

CY

Cycloblastin

Cyclophosphamid

cyclophosphamide

Cyclophosphamide

Cyclophosphamide (anhydrous form)

Cyclophosphamide (anhydrous)

Cyclophosphamide (INN)

Cyclophosphamide (TN)

Cyclophosphamide anhydrous

Cyclophosphamide monohydrate

Cyclophosphamide Monohydrate

Cyclophosphamide Sterile

Cyclophosphamide, (+-)-Isomer

Cyclophosphamide, (R)-isomer

Cyclophosphamide, (S)-isomer

Cyclophosphamides

Cyclophosphamidum

Cyclophosphamidum [INN-Latin]

Cyclophosphan

Cyclophosphane

Cyclophosphanum

Cyclophosphoramide

Cyclostin

Cyklofosfamid

Cyklofosfamid [Czech]

Cytophosphan

Cytophosphane

Cytoxan

Cytoxan (TN)

Cytoxan Lyoph

D,L-Cyclophosphamide

D07760

DB00531

DivK1c_000246

EINECS 200-015-4

Endoxan

Endoxan R

Endoxana

Endoxanal

Endoxan-Asta

Endoxane

Enduxan

EU-0100238

Genoxal

Hexadrin

HMS2090A12

HSDB 3047

IDI1_000246

KBio1_000246

KBio2_001338

KBio2_003906

KBio2_006474

KBio3_001319

KBioGR_000888

KBioSS_001338

Lopac0_000238

Lopac-C-0768

LS-1302

LS-99787

Lyophilized Cytoxan

Mitoxan

MolPort-001-783-420

Monohydrate, cyclophosphamide

N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide

N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

NCGC00015209-01

NCGC00015209-03

NCGC00015209-06

NCGC00091741-02

NCGC00091741-03

NCI60_002097

NCI-C04900

Neosar

NINDS_000246

NSC 26271

NSC26271

NSC-26271

NSC273033

NSC273034

Occupation, cyclophosphamide exposure

Procytox

RCRA waste no. U058

Rcra waste number U058

Rcra Waste Number U058

Revimmune

S1217_Selleck

Semdoxan

Sendoxan

Senduxan

SK 20501

SPBio_001071

Spectrum_000858

Spectrum2_001146

Spectrum3_000370

Spectrum4_000304

Spectrum5_000795

STK177249

STOCK2S-91217

UNII-6UXW23996M

WLN: T6MPOTJ BO BN2G2G

Zyklophosphamid

Zyklophosphamid [German]

3

Vaccines

Phase 1, Phase 2

4

Alkylating Agents

Phase 1, Phase 2

5

Anti-Inflammatory Agents

Phase 1, Phase 2

6

Anti-Inflammatory Agents, Non-Steroidal

Phase 1, Phase 2

7

Cyclooxygenase Inhibitors

Phase 1, Phase 2

8

Analgesics, Non-Narcotic

Phase 1, Phase 2

9

Cyclooxygenase 2 Inhibitors

Phase 1, Phase 2

10

Antirheumatic Agents

Phase 1, Phase 2

11

Immunosuppressive Agents

Phase 1, Phase 2

12

Analgesics

Phase 1, Phase 2

13

Immunologic Factors

Phase 1, Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Adjuvant Tumor Lysate Vaccine and Iscomatrix With or Without Metronomic Oral Cyclophosphamide and Celecoxib in Patients With Malignancies Involving Lungs, Esophagus, Pleura, or Mediastinum	Suspended	NCT02054104	Phase 1, Phase 2	Cyclophosphamide;Celecoxib

Search NIH Clinical Center for Mediastinum Sarcoma

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Genetic Tests for Mediastinum Sarcoma

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Anatomical Context for Mediastinum Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Mediastinum Sarcoma:

¹⁹

Mediastinum

MalaCards organs/tissues related to Mediastinum Sarcoma:

⁴⁰

Lung, Myeloid, Bone, Liver, Testis, Heart, Kidney

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Publications for Mediastinum Sarcoma

Articles related to Mediastinum Sarcoma:

#	Title	Authors	PMID	Year
1	Follicular dendritic cell sarcoma of mediastinum: a key role of radiotherapy in a multidisciplinary approach. ⁶¹	Spatola C...Privitera G	26638926	2015
2	[Primary soft tissue sarcomas of mediastinum: experience in 22 cases from a single institution]. ⁶¹	Mu JW...He J	18642788	2008
3	Myelodysplasia presenting as granulocytic sarcoma of mediastinum causing superior vena cava syndrome. ⁶¹	Ravandi-Kashani F...Giles FJ	10784409	2000

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Genes for Mediastinum Sarcoma

Genes related to Mediastinum Sarcoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MDM2	MDM2 Proto-Oncogene	Protein Coding	5.17	DISEASES inferred ¹⁵
2	CDK4	Cyclin Dependent Kinase 4	Protein Coding	5.14	DISEASES inferred ¹⁵
3	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	4.42	DISEASES inferred ¹⁵
4	CALB2	Calbindin 2	Protein Coding	4.18	DISEASES inferred ¹⁵
5	KRT19	Keratin 19	Protein Coding	3.83	DISEASES inferred ¹⁵
6	KRT7	Keratin 7	Protein Coding	3.69	DISEASES inferred ¹⁵
7	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	3.47	DISEASES inferred ¹⁵
8	CD68	CD68 Molecule	Protein Coding	3.45	DISEASES inferred ¹⁵
9	ATM	ATM Serine/Threonine Kinase	Protein Coding	3.42	DISEASES inferred ¹⁵

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Variations for Mediastinum Sarcoma

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Expression for Mediastinum Sarcoma

Search GEO for disease gene expression data for Mediastinum Sarcoma.

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Pathways for Mediastinum Sarcoma

Pathways related to Mediastinum Sarcoma according to GeneCards Suite gene sharing:

(show all 25)

#	Super pathways	Score	Top Affiliating Genes
1	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	12.69	MDM2 CDKN2A CDK4 ATM
2	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.42	MDM2 CDKN2A CDK4 ATM
3	Mitotic G1-G1/S phases ⁶⁵ Show member pathways G1 to S cell cycle control ¹ G1/S Transition ⁶⁵	12.33	MDM2 CDKN2A CDK4 ATM
4	DNA Damage ⁴	12.27	MDM2 CDKN2A CDK4 ATM
5	Cyclins and Cell Cycle Regulation ⁶³ Show member pathways Cell Cycle Control by BTG Proteins ⁶³ Cyclin D associated events in G1 ⁶⁵ G1 Phase ⁶⁵ G1-S Phase Transition ⁶³ Phosphorylation of proteins involved in G1/S transition by active Cyclin E-Cdk2 complexes ⁶⁵	12.14	CDKN2A CDK4 ATM
6	Human T-cell leukemia virus 1 infection ³⁶	12.12	CDKN2A CDK4 ATM
7	Viral carcinogenesis ³⁶	12.07	MDM2 CDKN2A CDK4
8	DNA Damage Response ¹ Show member pathways miRNA Regulation of DNA Damage Response ¹ p53 signaling pathway ³⁶	12.07	MDM2 CDKN2A CDK4 ATM
9	p53 Signaling ⁶³ Show member pathways p53 Pathway ⁶⁶	12.03	MDM2 CDK4 ATM
10	Cell cycle ¹ ³⁶	12.03	MDM2 CDKN2A CDK4 ATM
11	Integrated Breast Cancer Pathway ¹	11.92	MDM2 CDK4 ATM
12	DNA Damage Response (only ATM dependent) ¹	11.78	MDM2 CDKN2A ATM
13	Glioblastoma Multiforme ⁶³	11.76	MDM2 CDKN2A CDK4
14	Cellular senescence (KEGG) ³⁶	11.66	MDM2 CDKN2A CDK4 ATM
15	Regulation of TP53 Expression and Degradation ⁶⁵ Show member pathways Regulation of TP53 Degradation ⁶⁵ Regulation of TP53 Expression ⁶⁵	11.52	MDM2 CDKN2A ATM
16	Platinum drug resistance ³⁶	11.5	MDM2 CDKN2A ATM
17	Transcription_P53 signaling pathway ²²	11.48	MDM2 CDKN2A ATM
18	Bladder cancer ³⁶ ¹	11.47	MDM2 CDKN2A CDK4
19	Integrated Cancer Pathway ¹	11.16	MDM2 CDK4 ATM
20	Ovarian Infertility Genes ¹	11.13	CDK4 ATM
21	GADD45 Pathway ⁶³	11.12	CDK4 ATM
22	DNA damage_ATM/ATR regulation of G1/S checkpoint ²²	11.08	MDM2 CDK4 ATM
23	Inhibition of Ribosome Biogenesis by p14(ARF) ⁶³	10.92	MDM2 CDKN2A
24	Oncogene Induced Senescence ⁶⁵	10.64	MDM2 CDKN2A CDK4
25	TP53 Network ¹ Show member pathways Activation, translocation and oligomerization of BAX ⁶⁵	10.14	MDM2 CDKN2A ATM

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GO Terms for Mediastinum Sarcoma

Biological processes related to Mediastinum Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	viral process	GO:0016032	9.46	NCAM1 MDM2 KRT7 KRT19
2	positive regulation of cell cycle	GO:0045787	9.4	MDM2 CDK4
3	cellular response to gamma radiation	GO:0071480	9.37	MDM2 ATM
4	negative regulation of cell cycle arrest	GO:0071157	9.32	MDM2 CDK4
5	negative regulation of B cell proliferation	GO:0030889	9.26	CDKN2A ATM
6	replicative senescence	GO:0090399	8.96	CDKN2A ATM
7	amyloid fibril formation	GO:1990000	8.62	MDM2 CDKN2A

Molecular functions related to Mediastinum Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	disordered domain specific binding	GO:0097718	8.96	MDM2 CDKN2A
2	SUMO transferase activity	GO:0019789	8.62	MDM2 CDKN2A

Sources

Sources for Mediastinum Sarcoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia