Mediastinum Sarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MDS023 MIFTS: 30	Mediastinum Sarcoma Categories: Cancer diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Mediastinum Sarcoma

MalaCards integrated aliases for Mediastinum Sarcoma:

Name: Mediastinum Sarcoma ¹² ¹⁵

Sarcoma of Mediastinum ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4050

NCIt ⁵⁰ C6606

UMLS ⁷² C1334678

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Summaries for Mediastinum Sarcoma

Disease Ontology : ¹² A sarcoma and malignant mediastinal mesenchymnal tumor that is located in the mediastinum.

MalaCards based summary : Mediastinum Sarcoma, also known as sarcoma of mediastinum, is related to mediastinum synovial sarcoma and pleomorphic liposarcoma. An important gene associated with Mediastinum Sarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Cell Cycle, Mitotic and Cellular Senescence (REACTOME). The drugs Celecoxib and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include lung and mediastinum, and related phenotypes are digestive/alimentary and liver/biliary system

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Related Diseases for Mediastinum Sarcoma

Diseases related to Mediastinum Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)

#	Related Disease	Score	Top Affiliating Genes
1	mediastinum synovial sarcoma	11.4
2	pleomorphic liposarcoma	10.0	MDM2 CDKN2A
3	sarcoma	10.0
4	spindle cell sarcoma	10.0
5	verrucous carcinoma	10.0	MDM2 CDKN2A
6	cellular schwannoma	10.0	MDM2 CDKN2A
7	cerebrum cancer	9.9	MDM2 CDKN2A
8	supratentorial cancer	9.9	MDM2 CDKN2A
9	skin melanoma	9.9	MDM2 CDKN2A
10	cornea cancer	9.9	CDKN2A CDK4
11	leukemia, acute myeloid	9.9
12	leukemia, chronic myeloid	9.9
13	myelodysplastic syndrome	9.9
14	follicular dendritic cell sarcoma	9.9
15	myeloid sarcoma	9.9
16	myeloid leukemia	9.9
17	soft tissue sarcoma	9.9
18	ewing's family of tumors	9.8	CDKN2A CDK4
19	ring chromosome 7	9.8	MDM2 CDK4
20	salivary gland carcinoma	9.8	MDM2 CDKN2A
21	undifferentiated embryonal sarcoma of the liver	9.8	MDM2 CDK4
22	embryonal sarcoma	9.8	MDM2 CDK4
23	spindle cell lipoma	9.8	MDM2 CDK4
24	inflammatory mfh	9.8	MDM2 CDK4
25	cellular myxoid liposarcoma	9.8	MDM2 CDK4
26	myxoid liposarcoma	9.8	MDM2 CDK4
27	lipoblastoma	9.8	MDM2 CDK4
28	bone osteosarcoma	9.8	MDM2 CDK4
29	malignant fibrous histiocytoma of bone	9.8	MDM2 CDK4
30	mixed liposarcoma	9.8	MDM2 CDK4
31	chondroid lipoma	9.7	MDM2 CDK4
32	periosteal osteogenic sarcoma	9.7	MDM2 CDK4
33	spindle cell liposarcoma	9.7	MDM2 CDK4
34	infiltrating lipoma	9.7	MDM2 CDK4
35	small cell sarcoma	9.7	MDM2 CDK4
36	li-fraumeni syndrome	9.7	MDM2 CDKN2A
37	juxtacortical osteosarcoma	9.7	MDM2 CDK4
38	peripheral osteosarcoma	9.7	MDM2 CDK4
39	lipomatosis, multiple	9.7	MDM2 CDK4
40	malignant fibroxanthoma	9.7	MDM2 CDK4
41	malignant mesenchymoma	9.7	MDM2 CDK4
42	connective tissue cancer	9.7	MDM2 CDK4
43	rhabdomyosarcoma 2	9.6	MDM2 CDK4
44	rhabdomyosarcoma	9.6	MDM2 CDK4
45	inflammatory myofibroblastic tumor	9.5	MDM2 CDK4
46	leiomyosarcoma	9.5	MDM2 CDK4
47	melanoma, uveal	9.5	CDKN2A CDK4
48	myeloma, multiple	9.5	CDKN2A CDK4
49	infiltrating angiolipoma	9.3	MDM2 CDKN2A CDK4
50	periosteal chondrosarcoma	9.3	MDM2 CDKN2A CDK4

Graphical network of the top 20 diseases related to Mediastinum Sarcoma:

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Symptoms & Phenotypes for Mediastinum Sarcoma

MGI Mouse Phenotypes related to Mediastinum Sarcoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.5	CDK4 CDKN2A MDM2
2	liver/biliary system	MP:0005370	9.43	CDK4 CDKN2A MDM2
3	muscle	MP:0005369	9.33	CDK4 CDKN2A MDM2
4	neoplasm	MP:0002006	9.13	CDK4 CDKN2A MDM2
5	pigmentation	MP:0001186	8.8	CDK4 CDKN2A MDM2

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Drugs & Therapeutics for Mediastinum Sarcoma

Drugs for Mediastinum Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Celecoxib

Approved, Investigational

Phase 1, Phase 2

169590-42-5

2662

Synonyms:

169590-42-5

184007-95-2

1oq5

4-(5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1Hpyrazol-1-yl] benzenesulfonamide

4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE

4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide

AC1L1E6K

AC-4228

AI-525

Benzenesulfonamide,4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)

BIDD:GT0408

BRD-K02637541-001-02-4

BSPBio_003596

C07589

C105934

C17H14F3N3O2S

CCRIS 8679

CEL

Celebra

Celebrex

Celebrex (TN)

Celebrex, Celebra, Celecoxib

Celecox

Celecoxi

celecoxib

Celecoxib

Célécoxib

Celecoxib (JAN/USAN/INN)

Celecoxib (SC-58635)

Celecoxib [Old RN]

Celecoxib [USAN]

Celecoxibum

Celocoxib

CEP-33222

CHEBI:41423

CHEMBL118

CID2662

cMAP_000027

CPD000550473

D00567

DB00482

DivK1c_000893

Eurocox

FT-0080064

HMS1922G14

HMS2089L18

HMS2093I07

HMS502M15

HSDB 7038

I01-1033

IDI1_000893

KBio1_000893

KBio2_000912

KBio2_002351

KBio2_003480

KBio2_004919

KBio2_006048

KBio2_007487

KBio3_002830

KBio3_003037

KBioGR_000723

KBioGR_002351

KBioSS_000912

KBioSS_002354

LS-31667

Medicoxib

MLS001165684

MLS001195656

MLS001304708

MolPort-002-885-815

NCGC00091455-01

NCGC00091455-02

NCGC00091455-03

NCGC00091455-04

NCI60_041049

NINDS_000893

NSC719627

Onsenal

p-(5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide

P-(5-P-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide

P-(5-P-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulphonamide

Pfizer brand of celecoxib

S1261_Selleck

SAM002589995

SC 58635

SC-58553, SC-58635

SC58635

SC-58635

SMR000550473

Solexa

SPBio_001512

Spectrum_000432

SPECTRUM1503678

Spectrum2_001576

Spectrum3_001996

Spectrum4_000182

Spectrum5_001324

TL8001323

TPI-336

UNM-0000305813

Xilebao

YM 177

YM177

YM-177

ZINC02570895

Cyclophosphamide

Approved, Investigational

Phase 1, Phase 2

50-18-0, 6055-19-2

2907

Synonyms:

(-)-Cyclophosphamide

(+-)-Cyclophosphamide

(RS)-Cyclophosphamide

1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine

1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin

2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide

4-Hydroxy-cyclophosphan-mamophosphatide

50-18-0

60007-95-6

6055-19-2 (monohydrate)

75526-90-8

AC1L1EQQ

AI3-26198

Anhydrous cyclophosphamide

Anhydrous, cyclophosphamide

ASTA

Asta B 518

ASTA B518

B 518

B-518

bis(2-Chloroethyl)phosphami de cyclic propanolamide

bis(2-Chloroethyl)phosphamide cyclic propanolamide ester

Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester

BRN 0011744

BSPBio_002099

C 0768

C07888

C7H15Cl2N2O2P

CB 4564

CB-4564

CCRIS 188

CHEBI:4027

CHEMBL32520

CHEMBL88

Ciclofosfamida

Ciclofosfamida [INN-Spanish]

Ciclofosfamide

Ciclophosphamide

Ciclophosphamide [INN]

CID2907

Clafen

Claphene

CPA

CTX

Cycloblastin

Cyclophosphamid

cyclophosphamide

Cyclophosphamide

Cyclophosphamide (anhydrous form)

Cyclophosphamide (anhydrous)

Cyclophosphamide (INN)

Cyclophosphamide (TN)

Cyclophosphamide anhydrous

Cyclophosphamide monohydrate

Cyclophosphamide Monohydrate

Cyclophosphamide Sterile

Cyclophosphamide, (+-)-Isomer

Cyclophosphamide, (R)-isomer

Cyclophosphamide, (S)-isomer

Cyclophosphamides

Cyclophosphamidum

Cyclophosphamidum [INN-Latin]

Cyclophosphan

Cyclophosphane

Cyclophosphanum

Cyclophosphoramide

Cyclostin

Cyklofosfamid

Cyklofosfamid [Czech]

Cytophosphan

Cytophosphane

Cytoxan

Cytoxan (TN)

Cytoxan Lyoph

D,L-Cyclophosphamide

D07760

DB00531

DivK1c_000246

EINECS 200-015-4

Endoxan

Endoxan R

Endoxana

Endoxanal

Endoxan-Asta

Endoxane

Enduxan

EU-0100238

Genoxal

Hexadrin

HMS2090A12

HSDB 3047

IDI1_000246

KBio1_000246

KBio2_001338

KBio2_003906

KBio2_006474

KBio3_001319

KBioGR_000888

KBioSS_001338

Lopac0_000238

Lopac-C-0768

LS-1302

LS-99787

Lyophilized Cytoxan

Mitoxan

MolPort-001-783-420

Monohydrate, cyclophosphamide

N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide

N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

NCGC00015209-01

NCGC00015209-03

NCGC00015209-06

NCGC00091741-02

NCGC00091741-03

NCI60_002097

NCI-C04900

Neosar

NINDS_000246

NSC 26271

NSC26271

NSC-26271

NSC273033

NSC273034

Occupation, cyclophosphamide exposure

Procytox

RCRA waste no. U058

Rcra waste number U058

Rcra Waste Number U058

Revimmune

S1217_Selleck

Semdoxan

Sendoxan

Senduxan

SK 20501

SPBio_001071

Spectrum_000858

Spectrum2_001146

Spectrum3_000370

Spectrum4_000304

Spectrum5_000795

STK177249

STOCK2S-91217

UNII-6UXW23996M

WLN: T6MPOTJ BO BN2G2G

Zyklophosphamid

Zyklophosphamid [German]

Analgesics

Phase 1, Phase 2

Cyclooxygenase Inhibitors

Phase 1, Phase 2

Vaccines

Phase 1, Phase 2

Alkylating Agents

Phase 1, Phase 2

Cyclooxygenase 2 Inhibitors

Phase 1, Phase 2

Anti-Inflammatory Agents, Non-Steroidal

Phase 1, Phase 2

Immunologic Factors

Phase 1, Phase 2

Peripheral Nervous System Agents

Phase 1, Phase 2

Analgesics, Non-Narcotic

Phase 1, Phase 2

Immunosuppressive Agents

Phase 1, Phase 2

Anti-Inflammatory Agents

Phase 1, Phase 2

Antineoplastic Agents, Alkylating

Phase 1, Phase 2

Antirheumatic Agents

Phase 1, Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Adjuvant Tumor Lysate Vaccine and Iscomatrix With or Without Metronomic Oral Cyclophosphamide and Celecoxib in Patients With Malignancies Involving Lungs, Esophagus, Pleura, or Mediastinum	Suspended	NCT02054104	Phase 1, Phase 2	Cyclophosphamide;Celecoxib

Search NIH Clinical Center for Mediastinum Sarcoma

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Genetic Tests for Mediastinum Sarcoma

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Anatomical Context for Mediastinum Sarcoma

MalaCards organs/tissues related to Mediastinum Sarcoma:

⁴¹

Lung

The Foundational Model of Anatomy Ontology organs/tissues related to Mediastinum Sarcoma:

¹⁹

Mediastinum

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Publications for Mediastinum Sarcoma

Articles related to Mediastinum Sarcoma:

#	Title	Authors	PMID	Year
1	Follicular dendritic cell sarcoma of mediastinum: a key role of radiotherapy in a multidisciplinary approach. ³⁸	Spatola C...Privitera G	26638926	2015
2	[Primary soft tissue sarcomas of mediastinum: experience in 22 cases from a single institution]. ³⁸	Mu JW...He J	18642788	2008
3	Myelodysplasia presenting as granulocytic sarcoma of mediastinum causing superior vena cava syndrome. ³⁸	Ravandi-Kashani F...Giles FJ	10784409	2000

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Genes for Mediastinum Sarcoma

Genes related to Mediastinum Sarcoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MDM2	MDM2 Proto-Oncogene	Protein Coding	14.47	DISEASES inferred ¹⁵
2	CDK4	Cyclin Dependent Kinase 4	Protein Coding	14.38	DISEASES inferred ¹⁵
3	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	13.84	DISEASES inferred ¹⁵

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Variations for Mediastinum Sarcoma

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Expression for Mediastinum Sarcoma

Search GEO for disease gene expression data for Mediastinum Sarcoma.

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Pathways for Mediastinum Sarcoma

Pathways related to Mediastinum Sarcoma according to GeneCards Suite gene sharing:

(show all 32)

#	Super pathways	Score	Top Affiliating Genes
1	Cell Cycle, Mitotic ⁶⁶ Show member pathways Cell Cycle ⁶⁶ M Phase ⁶⁶	12.99	MDM2 CDKN2A CDK4
2	Cellular Senescence (REACTOME) ⁶⁶ Show member pathways Cellular responses to stress ⁶⁶ Cellular Senescence ⁶⁶ Senescence-Associated Secretory Phenotype (SASP) ⁶⁶	12.73	MDM2 CDKN2A CDK4
3	Human cytomegalovirus infection ³⁷ Show member pathways Human immunodeficiency virus 1 infection ³⁷ Kaposi sarcoma-associated herpesvirus infection ³⁷	12.56	MDM2 CDKN2A CDK4
4	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.48	MDM2 CDKN2A CDK4
5	Pathways in cancer ³⁷	12.42	MDM2 CDKN2A CDK4
6	Glioma ³⁷ Show member pathways Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.28	MDM2 CDKN2A CDK4
7	Mitotic G1-G1/S phases ⁶⁶ Show member pathways G1 to S cell cycle control ¹ G1/S Transition ⁶⁶	12.15	MDM2 CDKN2A CDK4
8	DNA Damage ⁴	12.08	MDM2 CDKN2A CDK4
9	Cyclins and Cell Cycle Regulation ⁶⁴ Show member pathways Cell Cycle Control by BTG Proteins ⁶⁴ Cyclin D associated events in G1 ⁶⁶ G1 Phase ⁶⁶ G1-S Phase Transition ⁶⁴ Phosphorylation of proteins involved in G1/S transition by active Cyclin E-Cdk2 complexes ⁶⁶	12	CDKN2A CDK4
10	DNA Damage Response ¹ Show member pathways miRNA Regulation of DNA Damage Response ¹ p53 signaling pathway ³⁷	11.95	MDM2 CDKN2A CDK4
11	p53 Signaling ⁶⁴ Show member pathways p53 Pathway ⁶⁷	11.9	MDM2 CDK4
12	Cell cycle ¹ ³⁷	11.9	MDM2 CDKN2A CDK4
13	Cell cycle Role of SCF complex in cell cycle regulation ²² Show member pathways Cell cycle ESR1 regulation of G1/S transition ²² Cell cycle Regulation of G1/S transition (part 1) ²² Immune response MIF-JAB1 signaling ²²	11.89	CDKN2A CDK4
14	Integrated Breast Cancer Pathway ¹	11.81	MDM2 CDK4
15	AKT Signaling Pathway ⁶⁷	11.8	MDM2 CDK4
16	Viral carcinogenesis ³⁷	11.8	MDM2 CDKN2A CDK4
17	SMAD Signaling Network ⁶⁴	11.72	MDM2 CDKN2A
18	DNA Damage Response (only ATM dependent) ¹	11.68	MDM2 CDKN2A
19	Senescence and Autophagy in Cancer ¹	11.64	MDM2 CDKN2A
20	Cellular senescence (KEGG) ³⁷	11.64	MDM2 CDKN2A CDK4
21	Retinoblastoma (RB) in Cancer ¹	11.54	MDM2 CDK4
22	Regulation of TP53 Expression and Degradation ⁶⁶ Show member pathways Regulation of TP53 Degradation ⁶⁶ Regulation of TP53 Expression ⁶⁶	11.45	MDM2 CDKN2A
23	Platinum drug resistance ³⁷	11.44	MDM2 CDKN2A
24	Glioblastoma Multiforme ⁶⁴	11.38	MDM2 CDKN2A CDK4
25	Transcription_P53 signaling pathway ²²	11.37	MDM2 CDKN2A
26	HIF1Alpha Pathway ⁶⁴	11.3	MDM2 CDKN2A
27	Integrated Cancer Pathway ¹	11.21	MDM2 CDK4
28	DNA damage_ATM/ATR regulation of G1/S checkpoint ²²	11.18	MDM2 CDK4
29	Bladder cancer ³⁷ ¹	11	MDM2 CDKN2A CDK4
30	TP53 Network ¹ Show member pathways Activation, translocation and oligomerization of BAX ⁶⁶	10.84	MDM2 CDKN2A
31	Inhibition of Ribosome Biogenesis by p14(ARF) ⁶⁴	10.82	MDM2 CDKN2A
32	Oncogene Induced Senescence ⁶⁶	10.3	MDM2 CDKN2A CDK4

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GO Terms for Mediastinum Sarcoma

Cellular components related to Mediastinum Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleolus	GO:0005730	8.8	MDM2 CDKN2A CDK4

Biological processes related to Mediastinum Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of gene expression	GO:0010468	9.43	MDM2 CDK4
2	response to toxic substance	GO:0009636	9.4	MDM2 CDK4
3	G1/S transition of mitotic cell cycle	GO:0000082	9.37	CDKN2A CDK4
4	positive regulation of cell cycle	GO:0045787	9.32	MDM2 CDK4
5	protein destabilization	GO:0031648	9.26	MDM2 CDKN2A
6	protein sumoylation	GO:0016925	9.16	MDM2 CDKN2A
7	negative regulation of cell cycle arrest	GO:0071157	8.96	MDM2 CDK4
8	amyloid fibril formation	GO:1990000	8.62	MDM2 CDKN2A

Molecular functions related to Mediastinum Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	disordered domain specific binding	GO:0097718	8.96	MDM2 CDKN2A
2	SUMO transferase activity	GO:0019789	8.62	MDM2 CDKN2A

Sources

Sources for Mediastinum Sarcoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ TGDB

⁷¹ Tocris

⁷² UMLS

⁷³ UMLS via Orphanet

⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia