MCID: MDS023
MIFTS: 33

Mediastinum Sarcoma

Categories: Cancer diseases

Aliases & Classifications for Mediastinum Sarcoma

MalaCards integrated aliases for Mediastinum Sarcoma:

Name: Mediastinum Sarcoma 12 15
Sarcoma of Mediastinum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4050
NCIt 49 C6606
UMLS 71 C1334678

Summaries for Mediastinum Sarcoma

Disease Ontology : 12 A sarcoma and malignant mediastinal mesenchymnal tumor that is located in the mediastinum.

MalaCards based summary : Mediastinum Sarcoma, also known as sarcoma of mediastinum, is related to spindle cell sarcoma and myeloid sarcoma. An important gene associated with Mediastinum Sarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Human cytomegalovirus infection and Glioma. The drugs Celecoxib and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include mediastinum, lung and myeloid, and related phenotypes are Reduced mammosphere formation and cellular

Related Diseases for Mediastinum Sarcoma

Diseases related to Mediastinum Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 277)
# Related Disease Score Top Affiliating Genes
1 spindle cell sarcoma 30.2 MDM2 KRT7
2 myeloid sarcoma 29.2 NCAM1 CD68
3 leukemia, acute myeloid 28.7 NCAM1 MDM2 CDKN2A CDK4 ATM
4 myelodysplastic syndrome 28.5 MDM2 CDKN2A CDK4 CD68 ATM
5 mediastinum synovial sarcoma 11.4
6 ring chromosome 7 10.4 MDM2 CDK4
7 ring chromosome 10.4 MDM2 CDK4
8 gastric liposarcoma 10.4 MDM2 CDK4
9 diffuse lipomatosis 10.4 MDM2 CDK4
10 undifferentiated embryonal sarcoma of the liver 10.4 MDM2 CDK4
11 embryonal sarcoma 10.4 MDM2 CDK4
12 spindle cell liposarcoma 10.4 MDM2 CDK4
13 pediatric liposarcoma 10.4 MDM2 CDK4
14 infiltrating lipoma 10.4 MDM2 CDK4
15 lipoblastoma 10.4 MDM2 CDK4
16 liposarcoma of bone 10.4 MDM2 CDK4
17 adult liposarcoma 10.4 MDM2 CDK4
18 juxtacortical osteosarcoma 10.4 MDM2 CDK4
19 pleomorphic lipoma 10.4 MDM2 CDK4
20 esophagus verrucous carcinoma 10.4 MDM2 CDKN2A
21 verrucous carcinoma 10.4 MDM2 CDKN2A
22 peripheral osteosarcoma 10.4 MDM2 CDK4
23 inflammatory liposarcoma 10.4 MDM2 CDKN2A
24 mixed liposarcoma 10.4 MDM2 CDK4
25 parameningeal embryonal rhabdomyosarcoma 10.4 MDM2 CDK4
26 cellular myxoid liposarcoma 10.4 MDM2 CDK4
27 peritoneal mesothelioma 10.3 CDKN2A CALB2
28 anal squamous cell carcinoma 10.3 MDM2 CDKN2A
29 nodular malignant melanoma 10.3 CDKN2A CDK4
30 aortic malignant tumor 10.3 MDM2 KRT7
31 bone osteosarcoma 10.3 MDM2 CDK4
32 fallopian tube endometrioid adenocarcinoma 10.3 CDKN2A CALB2
33 dysplastic nevus syndrome 10.3 CDKN2A CDK4
34 maxillary sinus adenocarcinoma 10.3 MDM2 ATM
35 cervical basaloid squamous cell carcinoma 10.3 KRT7 CDKN2A
36 inverted transitional papilloma 10.3 KRT7 CDKN2A
37 endometrial transitional cell carcinoma 10.2 KRT7 CDKN2A
38 anal canal paget's disease 10.2 KRT7 CDKN2A
39 anus basaloid carcinoma 10.2 KRT7 CDKN2A
40 cervical adenoid cystic carcinoma 10.2 KRT7 CDKN2A
41 atrophic vulva 10.2 KRT7 CDKN2A
42 hydrocele 10.2 KRT19 CALB2
43 gliomatosis cerebri 10.2 MDM2 CDKN2A
44 cystadenofibroma 10.2 KRT7 CALB2
45 ovarian seromucinous carcinoma 10.2 KRT7 CDKN2A
46 vaginal tubulovillous adenoma 10.2 KRT7 CDKN2A
47 pericardial mesothelioma 10.2 KRT19 CALB2
48 vaginal adenoma 10.2 KRT7 CDKN2A
49 vaginal benign neoplasm 10.2 KRT7 CDKN2A
50 cholangiolocellular carcinoma 10.2 KRT19 CDKN2A

Graphical network of the top 20 diseases related to Mediastinum Sarcoma:



Diseases related to Mediastinum Sarcoma

Symptoms & Phenotypes for Mediastinum Sarcoma

GenomeRNAi Phenotypes related to Mediastinum Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 ATM CDK4 KRT7 MDM2 NCAM1

MGI Mouse Phenotypes related to Mediastinum Sarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.7 ATM CDK4 CDKN2A KRT19 KRT7 MDM2
2 neoplasm MP:0002006 9.35 ATM CDK4 CDKN2A KRT19 MDM2
3 nervous system MP:0003631 9.17 ATM CALB2 CDK4 CDKN2A KRT19 MDM2

Drugs & Therapeutics for Mediastinum Sarcoma

Drugs for Mediastinum Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Celecoxib Approved, Investigational Phase 1, Phase 2 169590-42-5 2662
2
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
3 Vaccines Phase 1, Phase 2
4 Alkylating Agents Phase 1, Phase 2
5 Anti-Inflammatory Agents Phase 1, Phase 2
6 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
7 Cyclooxygenase Inhibitors Phase 1, Phase 2
8 Analgesics, Non-Narcotic Phase 1, Phase 2
9 Cyclooxygenase 2 Inhibitors Phase 1, Phase 2
10 Antirheumatic Agents Phase 1, Phase 2
11 Immunosuppressive Agents Phase 1, Phase 2
12 Analgesics Phase 1, Phase 2
13 Immunologic Factors Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Adjuvant Tumor Lysate Vaccine and Iscomatrix With or Without Metronomic Oral Cyclophosphamide and Celecoxib in Patients With Malignancies Involving Lungs, Esophagus, Pleura, or Mediastinum Suspended NCT02054104 Phase 1, Phase 2 Cyclophosphamide;Celecoxib

Search NIH Clinical Center for Mediastinum Sarcoma

Genetic Tests for Mediastinum Sarcoma

Anatomical Context for Mediastinum Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Mediastinum Sarcoma:

19
Mediastinum

MalaCards organs/tissues related to Mediastinum Sarcoma:

40
Lung, Myeloid, Bone, Liver, Testis, Heart, Kidney

Publications for Mediastinum Sarcoma

Articles related to Mediastinum Sarcoma:

# Title Authors PMID Year
1
Follicular dendritic cell sarcoma of mediastinum: a key role of radiotherapy in a multidisciplinary approach. 61
26638926 2015
2
[Primary soft tissue sarcomas of mediastinum: experience in 22 cases from a single institution]. 61
18642788 2008
3
Myelodysplasia presenting as granulocytic sarcoma of mediastinum causing superior vena cava syndrome. 61
10784409 2000

Variations for Mediastinum Sarcoma

Expression for Mediastinum Sarcoma

Search GEO for disease gene expression data for Mediastinum Sarcoma.

Pathways for Mediastinum Sarcoma

Pathways related to Mediastinum Sarcoma according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.69 MDM2 CDKN2A CDK4 ATM
2
Show member pathways
12.42 MDM2 CDKN2A CDK4 ATM
3
Show member pathways
12.33 MDM2 CDKN2A CDK4 ATM
4 12.27 MDM2 CDKN2A CDK4 ATM
5
Show member pathways
12.14 CDKN2A CDK4 ATM
6 12.12 CDKN2A CDK4 ATM
7 12.07 MDM2 CDKN2A CDK4
8
Show member pathways
12.07 MDM2 CDKN2A CDK4 ATM
9
Show member pathways
12.03 MDM2 CDK4 ATM
10 12.03 MDM2 CDKN2A CDK4 ATM
11 11.92 MDM2 CDK4 ATM
12 11.78 MDM2 CDKN2A ATM
13 11.76 MDM2 CDKN2A CDK4
14 11.66 MDM2 CDKN2A CDK4 ATM
15
Show member pathways
11.52 MDM2 CDKN2A ATM
16 11.5 MDM2 CDKN2A ATM
17 11.48 MDM2 CDKN2A ATM
18 11.47 MDM2 CDKN2A CDK4
19 11.16 MDM2 CDK4 ATM
20 11.13 CDK4 ATM
21 11.12 CDK4 ATM
22 11.08 MDM2 CDK4 ATM
23 10.92 MDM2 CDKN2A
24 10.64 MDM2 CDKN2A CDK4
25
Show member pathways
10.14 MDM2 CDKN2A ATM

GO Terms for Mediastinum Sarcoma

Biological processes related to Mediastinum Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.46 NCAM1 MDM2 KRT7 KRT19
2 positive regulation of cell cycle GO:0045787 9.4 MDM2 CDK4
3 cellular response to gamma radiation GO:0071480 9.37 MDM2 ATM
4 negative regulation of cell cycle arrest GO:0071157 9.32 MDM2 CDK4
5 negative regulation of B cell proliferation GO:0030889 9.26 CDKN2A ATM
6 replicative senescence GO:0090399 8.96 CDKN2A ATM
7 amyloid fibril formation GO:1990000 8.62 MDM2 CDKN2A

Molecular functions related to Mediastinum Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.96 MDM2 CDKN2A
2 SUMO transferase activity GO:0019789 8.62 MDM2 CDKN2A

Sources for Mediastinum Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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