Mediastinum Seminoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Mediastinum Seminoma

MalaCards integrated aliases for Mediastinum Seminoma:

Name: Mediastinum Seminoma ¹² ¹⁵

Seminoma of Mediastinum ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6249

NCIt ⁴⁹ C6812

UMLS ⁷¹ C1334680

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Summaries for Mediastinum Seminoma

MalaCards based summary : Mediastinum Seminoma, also known as seminoma of mediastinum, is related to embryonal carcinoma and teratoma. An important gene associated with Mediastinum Seminoma is ZNHIT2 (Zinc Finger HIT-Type Containing 2), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include brain, liver and ovary.

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Related Diseases for Mediastinum Seminoma

Diseases related to Mediastinum Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)

#	Related Disease	Score	Top Affiliating Genes
1	embryonal carcinoma	29.6	KIT AFP
2	teratoma	29.5	KIT AFP
3	seminoma	29.3	KIT ALPP AFP
4	choriocarcinoma	10.0
5	germ cells tumors	10.0
6	sertoli cell tumor	9.8	ALPP AFP
7	mixed germ cell tumor	9.8	KIT AFP
8	extragonadal seminoma	9.8	KIT AFP
9	ovarian mixed germ cell neoplasm	9.8	KIT AFP
10	gallbladder leiomyosarcoma	9.8	KIT AFP
11	intratubular embryonal carcinoma	9.8	KIT AFP
12	central nervous system germ cell tumor	9.8	KIT AFP
13	mixed germ cell cancer	9.8	KIT AFP
14	ovarian gonadoblastoma	9.8	KIT AFP
15	endometrial small cell carcinoma	9.7	KIT AFP
16	liver leiomyosarcoma	9.7	KIT AFP
17	brain germinoma	9.7	KIT AFP
18	dysgerminoma of ovary	9.7	KIT AFP
19	spermatocytoma	9.7	KIT AFP
20	mediastinal cancer	9.7	KIT AFP
21	ovarian germ cell cancer	9.7	KIT AFP
22	malignant teratoma	9.7	KIT AFP
23	mature teratoma	9.7	KIT AFP
24	endodermal sinus tumor	9.7	KIT AFP
25	gonadoblastoma	9.7	KIT ALPP
26	mixed cell type cancer	9.7	KIT AFP
27	cystic teratoma	9.7	KIT AFP
28	cystadenoma	9.6	KIT AFP
29	testicular cancer	9.6	ALPP AFP
30	cavernous hemangioma	9.6	KIT AFP
31	germ cell and embryonal cancer	9.6	KIT AFP
32	testicular disease	9.6	KIT AFP
33	obstructive jaundice	9.5	KIT ALPP
34	waardenburg's syndrome	9.4	KIT ALPP
35	cryptorchidism, unilateral or bilateral	9.4	KIT AFP
36	germinoma	9.3	KIT ALPP AFP
37	dysgerminoma	9.3	KIT ALPP AFP
38	testicular germ cell tumor	9.3	KIT ALPP AFP
39	germ cell cancer	9.3	KIT ALPP AFP
40	wilms tumor 1	9.2	KIT AFP

Graphical network of the top 20 diseases related to Mediastinum Seminoma:

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Symptoms & Phenotypes for Mediastinum Seminoma

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Drugs & Therapeutics for Mediastinum Seminoma

Search Clinical Trials , NIH Clinical Center for Mediastinum Seminoma

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Genetic Tests for Mediastinum Seminoma

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Anatomical Context for Mediastinum Seminoma

MalaCards organs/tissues related to Mediastinum Seminoma:

⁴⁰

Brain, Liver, Ovary

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Publications for Mediastinum Seminoma

Articles related to Mediastinum Seminoma:

#	Title	Authors	PMID	Year
1	Mixed germ cell tumour of the mediastinum (seminoma, embryonal carcinoma, choriocarcinoma and teratoma). Light and electron microscopic cytology and histological investigation. ⁶¹	Taccagni GL...Crespi G	2557596	1989

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Genes for Mediastinum Seminoma

Genes related to Mediastinum Seminoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ZNHIT2	Zinc Finger HIT-Type Containing 2	Protein Coding	6.64	DISEASES inferred ¹⁵
2	ALPP	Alkaline Phosphatase, Placental	Protein Coding	5.62	DISEASES inferred ¹⁵
3	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	3.87	DISEASES inferred ¹⁵
4	AFP	Alpha Fetoprotein	Protein Coding	3.85	DISEASES inferred ¹⁵

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Variations for Mediastinum Seminoma

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Expression for Mediastinum Seminoma

Search GEO for disease gene expression data for Mediastinum Seminoma.

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Pathways for Mediastinum Seminoma

Pathways related to Mediastinum Seminoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	10.75	ALPP AFP

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GO Terms for Mediastinum Seminoma

Molecular functions related to Mediastinum Seminoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	metal ion binding	GO:0046872	8.92	ZNHIT2 KIT ALPP AFP

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Sources for Mediastinum Seminoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

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⁹ Cosmic

¹⁰ dbSNP

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¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

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⁴⁷ NCBI Bookshelf

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⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

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⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

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⁶¹ PubMed

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⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

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⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia