MCID: MDL001
MIFTS: 22

Medulloadrenal Hyperfunction

Categories: Endocrine diseases

Aliases & Classifications for Medulloadrenal Hyperfunction

MalaCards integrated aliases for Medulloadrenal Hyperfunction:

Name: Medulloadrenal Hyperfunction 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:12257
ICD9CM 34 255.6
SNOMED-CT 67 111565003
ICD10 32 E27.5
UMLS 71 C0154206

Summaries for Medulloadrenal Hyperfunction

MalaCards based summary : Medulloadrenal Hyperfunction is related to generalized atherosclerosis and retinal vein occlusion. An important gene associated with Medulloadrenal Hyperfunction is SERPINE1 (Serpin Family E Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). Affiliated tissues include adrenal gland, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Medulloadrenal Hyperfunction

Diseases related to Medulloadrenal Hyperfunction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 generalized atherosclerosis 10.1 VWF SERPINE1
2 retinal vein occlusion 10.1 SERPINE1 F3
3 venous insufficiency 10.0 VWF SERPINE1
4 dic in newborn 10.0 SERPINE1 F3
5 catastrophic antiphospholipid syndrome 10.0 SERPINE1 F3
6 intermittent claudication 10.0 VWF SERPINE1
7 coronary stenosis 10.0 VWF SERPINE1
8 intracranial hypertension 10.0 SERPINE1 F3
9 limb ischemia 10.0 VWF SERPINE1
10 papillary adenofibroma 10.0 VWF F3
11 waterhouse-friderichsen syndrome 10.0 POMC F3
12 cavernous sinus thrombosis 10.0 POMC F3
13 qualitative platelet defect 10.0 VWF F3
14 protein s deficiency 10.0 SERPINE1 F3
15 splenic sequestration 10.0 VWF F3
16 acquired von willebrand syndrome 10.0 VWF F3
17 active peptic ulcer disease 10.0 VWF F3
18 hemarthrosis 10.0 VWF F3
19 thrombophilia due to thrombin defect 10.0 SERPINE1 F3
20 angiodysplasia 10.0 VWF F3
21 intracranial hypertension, idiopathic 10.0 POMC F3
22 von willebrand disease, type 1 10.0 VWF F3
23 homocysteinemia 10.0 VWF SERPINE1
24 primary thrombocytopenia 9.9 VWF F3
25 factor xii deficiency 9.9 VWF F3
26 factor v deficiency 9.9 VWF F3
27 mitral valve stenosis 9.9 VWF F3
28 hemophilia a 9.9 VWF F3
29 factor viii deficiency 9.9 VWF F3
30 factor xi deficiency 9.9 VWF F3
31 blood protein disease 9.9 VWF F3
32 von willebrand's disease 9.9 VWF F3
33 thrombotic thrombocytopenic purpura 9.9 VWF F3
34 purpura 9.9 VWF F3
35 livedoid vasculitis 9.9 SERPINE1 PLG
36 hemophilia b 9.9 VWF F3
37 peripheral artery disease 9.9 VWF F3
38 glanzmann thrombasthenia 9.9 VWF F3
39 basal ganglia cerebrovascular disease 9.8 POMC PLG
40 hemolytic uremic syndrome, atypical 1 9.8 VWF F3
41 takayasu arteritis 9.8 VWF F3
42 retinal artery occlusion 9.8 SERPINE1 PLG
43 bernard-soulier syndrome 9.8 VWF F3
44 hemolytic-uremic syndrome 9.8 VWF F3
45 thrombocytosis 9.8 VWF F3
46 blood platelet disease 9.8 VWF F3
47 osteonecrosis 9.8 SERPINE1 PLG
48 acute cor pulmonale 9.8 PLG F3
49 acute pulmonary heart disease 9.8 PLG F3
50 intracranial sinus thrombosis 9.8 PLG F3

Graphical network of the top 20 diseases related to Medulloadrenal Hyperfunction:



Diseases related to Medulloadrenal Hyperfunction

Symptoms & Phenotypes for Medulloadrenal Hyperfunction

MGI Mouse Phenotypes related to Medulloadrenal Hyperfunction:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.72 F3 PLG POMC SERPINE1 VWF
2 hematopoietic system MP:0005397 9.65 F3 PLG POMC SERPINE1 VWF
3 immune system MP:0005387 9.55 F3 PLG POMC SERPINE1 VWF
4 integument MP:0010771 9.26 F3 PLG POMC SERPINE1
5 neoplasm MP:0002006 8.92 F3 PLG POMC SERPINE1

Drugs & Therapeutics for Medulloadrenal Hyperfunction

Search Clinical Trials , NIH Clinical Center for Medulloadrenal Hyperfunction

Genetic Tests for Medulloadrenal Hyperfunction

Anatomical Context for Medulloadrenal Hyperfunction

MalaCards organs/tissues related to Medulloadrenal Hyperfunction:

40
Adrenal Gland

Publications for Medulloadrenal Hyperfunction

Variations for Medulloadrenal Hyperfunction

Expression for Medulloadrenal Hyperfunction

Search GEO for disease gene expression data for Medulloadrenal Hyperfunction.

Pathways for Medulloadrenal Hyperfunction

GO Terms for Medulloadrenal Hyperfunction

Cellular components related to Medulloadrenal Hyperfunction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 SERPINE1 POMC PLG F3
2 extracellular region GO:0005576 9.55 VWF SERPINE1 POMC PLG F3
3 collagen-containing extracellular matrix GO:0062023 9.26 VWF SERPINE1 PLG F3
4 platelet alpha granule lumen GO:0031093 8.8 VWF SERPINE1 PLG

Biological processes related to Medulloadrenal Hyperfunction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.43 VWF PLG F3
2 fibrinolysis GO:0042730 9.32 SERPINE1 PLG
3 negative regulation of fibrinolysis GO:0051918 9.16 SERPINE1 PLG
4 platelet degranulation GO:0002576 9.13 VWF SERPINE1 PLG
5 hemostasis GO:0007599 8.8 VWF PLG F3

Molecular functions related to Medulloadrenal Hyperfunction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 9.16 VWF PLG
2 signaling receptor binding GO:0005102 9.13 SERPINE1 POMC PLG
3 protease binding GO:0002020 8.8 VWF SERPINE1 F3

Sources for Medulloadrenal Hyperfunction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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