MCID: MDL003
MIFTS: 34

Medullomyoblastoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Medullomyoblastoma

MalaCards integrated aliases for Medullomyoblastoma:

Name: Medullomyoblastoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3861
MeSH 44 D008527
NCIt 50 C3706
SNOMED-CT 67 24604009
UMLS 70 C0205833

Summaries for Medullomyoblastoma

MalaCards based summary : Medullomyoblastoma is related to teratoma and embryonal rhabdomyosarcoma, and has symptoms including vomiting, headache and gait ataxia. An important gene associated with Medullomyoblastoma is MB (Myoglobin), and among its related pathways/superpathways are Translation Non-genomic (rapid) action of Androgen Receptor and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include cerebellum, spinal cord and smooth muscle, and related phenotypes are cardiovascular system and cellular

Related Diseases for Medullomyoblastoma

Diseases related to Medullomyoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
# Related Disease Score Top Affiliating Genes
1 teratoma 30.2 SYP SHH GFAP
2 embryonal rhabdomyosarcoma 29.9 MYOG MB DES
3 medulloepithelioma 29.8 SYP GFAP DES
4 rhabdoid cancer 29.4 SYP SHH MYOG DES
5 atypical teratoid rhabdoid tumor 29.4 SYP SHH GFAP DES
6 medulloblastoma 28.8 SYP SUFU SMO SHH OTX2 GFAP
7 rhabdomyosarcoma 28.7 SYP SUFU SHH MYOG MB GFAP
8 giant cell myocarditis 10.3 MB DES
9 inflammatory leiomyosarcoma 10.3 MYOG DES
10 gallbladder sarcoma 10.3 MYOG DES
11 cervical polyp 10.3 MYOG DES
12 gliomatosis peritonei 10.3 GFAP DES
13 ectomesenchymoma 10.3 MYOG DES
14 skeletal muscle neoplasm 10.3 MYOG MB
15 primitive neuroectodermal tumor of the cervix uteri 10.3 GFAP DES
16 orbit embryonal rhabdomyosarcoma 10.3 MYOG MB
17 epithelioid leiomyosarcoma 10.2 MB DES
18 embryonal sarcoma 10.2 MYOG DES
19 cutaneous leiomyosarcoma 10.2 GFAP DES
20 myofibroma 10.2 MB DES
21 parachordoma 10.2 GFAP DES
22 syringocystadenoma papilliferum 10.2 GFAP DES
23 pulmonary blastoma 10.2 SYP DES
24 breast rhabdomyosarcoma 10.2 MYOG MB
25 orbit rhabdomyosarcoma 10.2 MYOG MB
26 rare tumor 10.2
27 myoblastoma 10.2 SYP MYOG
28 adenosarcoma 10.2 MB DES
29 glomangioma 10.2 SYP DES
30 congenital fibrosarcoma 10.2 MYOG DES
31 syringoma 10.2 GFAP DES
32 myocardium cancer 10.2 SYP MYOG
33 kidney rhabdoid cancer 10.2 SYP MB
34 gas gangrene 10.2 MYOG MB
35 pineal region teratoma 10.2 SYP MYOG
36 glomangiomatosis 10.2 SYP MB
37 extracranial neuroblastoma 10.2 SYP MYOG
38 cervical neuroblastoma 10.2 SYP MYOG
39 pseudosarcomatous fibromatosis 10.2 MYOG DES
40 ovarian small cell carcinoma 10.2 SYP DES
41 extraventricular neurocytoma 10.2 SYP GFAP
42 central epithelioid sarcoma 10.2 SYP MB
43 prostate stromal sarcoma 10.2 SYP MYOG
44 desmoplastic infantile ganglioglioma 10.2 SYP GFAP
45 vulvar proximal-type epithelioid sarcoma 10.2 SYP MB
46 cerebral neuroblastoma 10.2 SYP GFAP
47 extraosseous ewing sarcoma 10.2 SYP MYOG
48 neuroleptic malignant syndrome 10.2 MB DES
49 cerebellopontine angle primitive neuroectodermal tumor 10.2 SYP GFAP
50 subleukemic leukemia 10.2 SYP MB

Graphical network of the top 20 diseases related to Medullomyoblastoma:



Diseases related to Medullomyoblastoma

Symptoms & Phenotypes for Medullomyoblastoma

UMLS symptoms related to Medullomyoblastoma:


vomiting; headache; gait ataxia

MGI Mouse Phenotypes related to Medullomyoblastoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10 DES GFAP MB OTX2 SHH SMO
2 cellular MP:0005384 9.98 DES GFAP MB MYOG OTX2 SHH
3 homeostasis/metabolism MP:0005376 9.92 DES GFAP MB MYOG OTX2 SHH
4 mortality/aging MP:0010768 9.86 DES GFAP MB MYOG OTX2 SHH
5 embryo MP:0005380 9.85 MB MYOG OTX2 SHH SMO SUFU
6 digestive/alimentary MP:0005381 9.8 GFAP OTX2 SHH SMO SUFU
7 muscle MP:0005369 9.7 DES GFAP MB MYOG OTX2 SHH
8 normal MP:0002873 9.5 GFAP MYOG OTX2 SHH SMO SUFU
9 respiratory system MP:0005388 9.1 MB MYOG OTX2 SHH SMO SUFU

Drugs & Therapeutics for Medullomyoblastoma

Search Clinical Trials , NIH Clinical Center for Medullomyoblastoma

Genetic Tests for Medullomyoblastoma

Anatomical Context for Medullomyoblastoma

MalaCards organs/tissues related to Medullomyoblastoma:

40
Cerebellum, Spinal Cord, Smooth Muscle, Pineal, Pituitary

Publications for Medullomyoblastoma

Articles related to Medullomyoblastoma:

(show top 50) (show all 63)
# Title Authors PMID Year
1
Medullomyoblastoma: A report of two cases. 61
28488644 2017
2
WNT-activated medulloblastoma with melanotic and myogenic differentiation: Report of a rare case. 61
26869281 2016
3
Medullomyoblastoma: A rare case in an unusual location in an atypical age group. 61
27366275 2016
4
Medullomyoblastoma treated with craniospinal radiation and adjuvant chemotherapy: Report of 4 cases and review of the literature. 61
25936510 2015
5
OTX2 represses myogenic and neuronal differentiation in medulloblastoma cells. 61
22986744 2012
6
Medullomyoblastoma: a case report and literature review of a rare tumor entity. 61
23155263 2012
7
Isochromosome 17q, MYC amplification and large cell/anaplastic phenotype in a case of medullomyoblastoma with extracranial metastases. 61
22147345 2012
8
Spinal cord glioblastoma induced by radiation therapy of nasopharyngeal rhabdomyosarcoma with MRI findings: case report. 61
22977336 2012
9
[Atypical teratoid/rhabdoid tumors of central nervous system in childhood: a clinical and histopathologic study of 6 cases]. 61
22800515 2012
10
Georges Marinesco (1863-1938): neurologist, neurohistologist and neuropathologist. 61
23303009 2012
11
[A case of medullomyoblastoma]. 61
22036819 2011
12
Cytoplasmic p63 immunohistochemistry is a useful marker for muscle differentiation: an immunohistochemical and immunoelectron microscopic study. 61
21623385 2011
13
A case of medullomyoblastoma. 61
21696510 2011
14
[Medullomyoblastoma: a medulloblastoma with rhabdomyoblastic differentiation]. 61
20451073 2010
15
Medulloblastoma with myogenic differentiation showing double immunopositivity for synaptophysin and myoglobin. 61
19351370 2009
16
Imaging of the unusual pediatric 'blastomas'. 61
19237343 2009
17
Georges Marinesco and the early research in neuropathology. 61
19122036 2009
18
Aggressive infantile embryonal tumors. 61
18952586 2008
19
The role of immunohistochemistry in medullomyoblastoma--a case series highlighting divergent differentiation. 61
18439235 2008
20
Medullomyoblastoma: teratoid nature of a quite rare neoplasm. 61
18261773 2008
21
Medullomyoblastoma with calcification: a case report. 61
18181837 2008
22
Cerebellar medullomyoblastoma with melanotic tubular structures. 61
16550533 2008
23
Concurrent gain of 17q and the MYC oncogene in a medullomyoblastoma. 61
18021376 2007
24
A 3 1/2-year-old child with a posterior fossa mass. Pigmented medullomyoblastoma. 61
16594755 2006
25
Unusually long survival in a case of medullomyoblastoma. 61
16326277 2005
26
A 10-month-old boy with a large pineal tumor. 61
16196394 2005
27
Medullomyoblastoma: a radiographic and clinicopathologic analysis of six cases and review of the literature. 61
15368333 2004
28
A case of medullomyoblastoma of cerebellopontine angle mimicking acoustic neuroma. 61
15344215 2004
29
Alpha-internexin expression in medulloblastomas and atypical teratoid-rhabdoid tumors. 61
14531545 2003
30
Medullomyoblastoma: case report. 61
11510933 2001
31
Large cell/anaplastic medulloblastomas and medullomyoblastomas: clinicopathological and genetic features. 61
11453402 2001
32
Spontaneous and ethyl-nitrosourea-induced medullomyoblastomas in cerebellar vermis defect (CVD) mutant rats. 61
10663971 2000
33
Ultrastructural changes in medullomyoblastoma. Similarities with foetal rhabdomyoma. 61
10514575 1999
34
Medullomyoblastoma: A case report. 61
10339710 1999
35
[Teratoma and medulloblastoma of the cerebellum: a case]. 61
10598377 1999
36
Medullomyoblastoma. A rare cerebellar tumour in children. 61
9726581 1998
37
Medullomyoblastoma: a histological, immunohistochemical, ultrastructural and molecular genetic study. 61
9498058 1998
38
Radiation-induced glioma of the spinal cord. 61
9293548 1996
39
[Usefulness and problems of high dose chemotherapy using CBDCA, VP-16, and MCNU with peripheral blood stem cell transplantation in pediatric malignant brain tumors]. 61
8753001 1996
40
Development of medullomyoblastoma from classical medulloblastoma following a long term latency. 61
8867688 1995
41
Medullomyoblastoma: report of two cases. 61
1327526 1992
42
Cerebellar medullomyoblastoma with advanced neuronal differentiation and hamartomatous component. 61
1662856 1991
43
[Medullomyoblastoma: immunohistochemical and ultrastructural study]. 61
2281954 1990
44
Medullomyoblastoma. 61
2290468 1990
45
Medullomyoblastoma in an adult. 61
2403482 1990
46
Medullomyoblastoma. A case report. 61
2561483 1989
47
Medullomyoblastoma: a case report. 61
2819571 1989
48
[The question of medullomyoblastoma]. 61
2816136 1989
49
Pigmented primitive neuroectodermal tumor with multipotential differentiation in cerebellum (pigmented medullomyoblastoma). A case with light- and electron-microscopic, and immunohistochemical analysis. 61
3136447 1987
50
Primitive cerebral neuroectodermal tumor with rhabdomyoblastic differentiation. 61
2426855 1986

Variations for Medullomyoblastoma

Expression for Medullomyoblastoma

Search GEO for disease gene expression data for Medullomyoblastoma.

Pathways for Medullomyoblastoma

GO Terms for Medullomyoblastoma

Cellular components related to Medullomyoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ciliary tip GO:0097542 8.62 SUFU SMO

Biological processes related to Medullomyoblastoma according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.97 SUFU SMO SHH OTX2 MYOG
2 positive regulation of transcription, DNA-templated GO:0045893 9.94 SMO SHH OTX2 MYOG
3 skin development GO:0043588 9.67 SUFU SHH
4 neural crest cell migration GO:0001755 9.66 SMO SHH
5 positive regulation of protein import into nucleus GO:0042307 9.66 SMO SHH
6 embryonic organ development GO:0048568 9.65 SMO SHH
7 dorsal/ventral pattern formation GO:0009953 9.65 SMO SHH
8 positive regulation of smoothened signaling pathway GO:0045880 9.65 SMO SHH
9 cell fate specification GO:0001708 9.64 SMO SHH
10 protein localization to nucleus GO:0034504 9.63 SMO SHH
11 midbrain development GO:0030901 9.63 SHH OTX2
12 determination of left/right symmetry GO:0007368 9.63 SUFU SMO SHH
13 cell development GO:0048468 9.62 SMO SHH
14 hair follicle morphogenesis GO:0031069 9.62 SMO SHH
15 developmental growth GO:0048589 9.61 SMO SHH
16 skeletal muscle fiber development GO:0048741 9.61 SMO MYOG
17 smoothened signaling pathway GO:0007224 9.61 SUFU SMO SHH
18 dopaminergic neuron differentiation GO:0071542 9.6 SHH OTX2
19 positive regulation of neuroblast proliferation GO:0002052 9.59 SMO SHH
20 positive regulation of mesenchymal cell proliferation GO:0002053 9.58 SMO SHH
21 myoblast differentiation GO:0045445 9.57 SHH MYOG
22 somite development GO:0061053 9.56 SMO SHH
23 cellular response to lithium ion GO:0071285 9.55 SHH MYOG
24 thalamus development GO:0021794 9.54 SMO SHH
25 myotube differentiation GO:0014902 9.52 SHH MYOG
26 dorsal/ventral neural tube patterning GO:0021904 9.51 SMO SHH
27 heart looping GO:0001947 9.5 SUFU SMO SHH
28 smooth muscle tissue development GO:0048745 9.49 SMO SHH
29 Bergmann glial cell differentiation GO:0060020 9.48 SHH GFAP
30 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.4 SMO SHH
31 spinal cord dorsal/ventral patterning GO:0021513 9.37 SUFU SHH
32 epithelial-mesenchymal cell signaling GO:0060684 9.26 SMO SHH
33 positive regulation of hh target transcription factor activity GO:0007228 9.16 SMO SHH
34 determination of left/right asymmetry in lateral mesoderm GO:0003140 8.96 SMO SHH
35 intermediate filament organization GO:0045109 8.8 SHH GFAP DES

Molecular functions related to Medullomyoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 patched binding GO:0005113 8.62 SMO SHH

Sources for Medullomyoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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