MCID: MGC001
MIFTS: 46

Megacolon

Categories: Gastrointestinal diseases

Aliases & Classifications for Megacolon

MalaCards integrated aliases for Megacolon:

Name: Megacolon 12 43 15 71
Dilatation of Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11372
MeSH 43 D008531
NCIt 49 C34810
ICD10 32 K59.3 K59.39
UMLS 71 C0025160

Summaries for Megacolon

Disease Ontology : 12 A colonic disease that is characterized by an abnormal dilation of the colon.

MalaCards based summary : Megacolon, also known as dilatation of colon, is related to goldberg-shprintzen syndrome and waardenburg's syndrome. An important gene associated with Megacolon is SOX10 (SRY-Box Transcription Factor 10), and among its related pathways/superpathways are Neural Crest Differentiation and GDNF-Family Ligands and Receptor Interactions. The drugs Nitrous oxide and Vancomycin have been mentioned in the context of this disorder. Affiliated tissues include colon, smooth muscle and thyroid, and related phenotypes are behavior/neurological and mortality/aging

Wikipedia : 74 Megacolon is an abnormal dilation of the colon (also called the large intestine). The dilation is often... more...

Related Diseases for Megacolon

Diseases related to Megacolon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 298)
# Related Disease Score Top Affiliating Genes
1 goldberg-shprintzen syndrome 34.0 RET PHOX2B KIFBP GDNF EDNRB EDN3
2 waardenburg's syndrome 32.9 SOX10 RET EDNRB EDN3
3 hirschsprung disease 5 32.6 RET HSCR5
4 hirschsprung disease 1 32.2 ZEB2 VIP TLX2 SOX10 RET PSPN
5 constipation 31.4 VIP RET NRTN GDNF EDNRB EDN3
6 hypoganglionosis 31.1 RET GDNF ACHE
7 intestinal obstruction 31.0 RET NRTN GDNF EDNRB EDN3 ACHE
8 waardenburg syndrome, type 4a 30.8 SOX10 RET EDNRB EDN3
9 intestinal pseudo-obstruction 30.8 TLX2 SOX10 RET EDN3 ACHE
10 achalasia 30.8 VIP RET GDNF EDN3 CHAT ACHE
11 pheochromocytoma 30.6 VIP RET GFRA1 GDNF EDN3
12 multiple endocrine neoplasia, type iib 30.5 RET PSPN NRTN GFRA1 GDNF
13 piebald trait 30.4 SOX10 EDNRB EDN3
14 thyroid carcinoma, familial medullary 30.0 RET PSPN NRTN GFRA1 GDNF
15 neuroblastoma 29.8 VIP RET PHOX2B GDNF CHAT ACHE
16 toxic megacolon 12.7
17 hirschsprung disease 2 12.0
18 ulcerative colitis 11.8
19 multiple endocrine neoplasia 11.5
20 hirschsprung disease 3 11.5
21 ifap syndrome with or without bresheck syndrome 11.3
22 hirschsprung disease 6 11.1
23 hirschsprung disease 7 11.1
24 hirschsprung disease 8 11.1
25 hirschsprung disease 9 11.1
26 hirschsprung disease 4 11.1
27 colitis 10.9
28 chagas disease 10.7
29 clostridium difficile colitis 10.6
30 waardenburg syndrome, type 2b 10.6 SOX10 EDN3
31 volvulus of midgut 10.6
32 medullary sponge kidney 10.6 RET GDNF
33 waardenburg syndrome type 4 10.6 SOX10 EDNRB EDN3
34 waardenburg syndrome, type 2c 10.6 SOX10 EDNRB EDN3
35 cochlear disease 10.5 SOX10 EDNRB EDN3
36 waardenburg syndrome, type 4c 10.5 SOX10 EDNRB EDN3
37 waardenburg syndrome, type 2e 10.5 SOX10 EDNRB EDN3
38 multiple mucosal neuroma 10.5 RET GDNF
39 peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease 10.5 SOX10 EDNRB EDN3
40 diarrhea 10.5
41 waardenburg syndrome, type 4b 10.5 SOX10 EDNRB EDN3
42 waardenburg syndrome, type 3 10.5 SOX10 EDNRB EDN3
43 skin lipoma 10.5 RET GFRA1
44 tietz albinism-deafness syndrome 10.5 SOX10 EDNRB EDN3
45 inflammatory bowel disease 10.5
46 waardenburg syndrome, type 1 10.5 SOX10 EDNRB EDN3
47 crohn's disease 10.5
48 neurogenic bowel 10.5 VIP ACHE
49 multiple endocrine neoplasia, type i 10.5 VIP RET MIR483
50 enterocolitis 10.5

Graphical network of the top 20 diseases related to Megacolon:



Diseases related to Megacolon

Symptoms & Phenotypes for Megacolon

MGI Mouse Phenotypes related to Megacolon:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.29 ACHE CHAT EDN3 EDNRB FOXP3 GDNF
2 mortality/aging MP:0010768 10.24 ACHE CHAT EDN3 EDNRB FOXP3 GDNF
3 digestive/alimentary MP:0005381 10.2 CHAT EDN3 EDNRB FOXP3 GDNF GFRA1
4 growth/size/body region MP:0005378 10.18 ACHE CHAT EDNRB FOXP3 GDNF KIFBP
5 nervous system MP:0003631 10.13 ACHE CHAT EDN3 EDNRB GDNF GFRA1
6 embryo MP:0005380 10.09 EDN3 EDNRB GFRA1 KIFBP PHOX2B RET
7 muscle MP:0005369 9.92 ACHE CHAT EDNRB GDNF GFRA1 KIFBP
8 reproductive system MP:0005389 9.81 ACHE CHAT FOXP3 GDNF KIFBP NRTN
9 respiratory system MP:0005388 9.61 ACHE CHAT EDNRB FOXP3 KIFBP PHOX2B
10 vision/eye MP:0005391 9.32 ACHE CHAT EDNRB FOXP3 KIFBP NRTN

Drugs & Therapeutics for Megacolon

Drugs for Megacolon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
2
Vancomycin Approved Phase 4 1404-90-6 14969 441141
3
Fidaxomicin Approved Phase 4 873857-62-6
4
Acetaminophen Approved Phase 4 103-90-2 1983
5
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
6
Cimetropium Experimental, Investigational Phase 4 150521-16-7
7 Parasympatholytics Phase 4
8 Cholinergic Agents Phase 4
9 Cholinergic Antagonists Phase 4
10 Neurotransmitter Agents Phase 4
11 Anticonvulsants Phase 4
12 Bromides Phase 4
13 Pharmaceutical Solutions Phase 4
14 Anesthetics, General Phase 4
15 Anesthetics, Inhalation Phase 4
16 Anti-Bacterial Agents Phase 4
17 Anti-Infective Agents Phase 4
18 Anesthetics Phase 4
19 Anesthetics, Local Phase 4
20
Bisacodyl Approved Phase 3 603-50-9
21
Sodium citrate Approved, Investigational Phase 3 68-04-2
22
Magnesium citrate Approved Phase 3 3344-18-1
23
Dimenhydrinate Approved Phase 3 523-87-5 441281
24
Metronidazole Approved Phase 2, Phase 3 443-48-1 4173
25
Citric acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
26 Citrate Phase 3
27 Chelating Agents Phase 3
28 Calcium, Dietary Phase 3
29 Picosulfate sodium Phase 3
30 Anticoagulants Phase 3
31 Tea Phase 3
32 Laxatives Phase 2, Phase 3
33 Cathartics Phase 2, Phase 3
34 Gastrointestinal Agents Phase 2, Phase 3
35 Antibiotics, Antitubercular Phase 2, Phase 3
36 Antitubercular Agents Phase 2, Phase 3
37 Antiprotozoal Agents Phase 2, Phase 3
38 Polyethylene glycol 3350 Phase 2, Phase 3
39
Calcium Nutraceutical Phase 3 7440-70-2 271
40
Furosemide Approved, Vet_approved Phase 2 54-31-9 3440
41
Nitazoxanide Approved, Investigational, Vet_approved Phase 1, Phase 2 55981-09-4 41684
42 Kava Approved, Investigational, Nutraceutical Phase 2 9000-38-8
43 Cola Phase 2
44 diuretics Phase 2
45 Antiparasitic Agents Phase 1, Phase 2
46 Analgesics, Non-Narcotic Phase 1, Phase 2
47 Analgesics Phase 1, Phase 2
48 Mesalamine Phase 1, Phase 2 89-57-6
49 Anti-Inflammatory Agents Phase 1, Phase 2
50 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 Usefulness Of Flospan As A Premedication For Colonoscopy : A Randomized Double Blind Controlled Trial Unknown status NCT01842932 Phase 4 Phloroglucin;Cimetropium bromide;Placebo
2 Use of Nitrous Oxide for Analgesia During Colonoscopy - A Randomised Trial Completed NCT00318825 Phase 4 Nitrous oxide
3 PEG-Electrolyte Solution (FORTRANS®) With Mentholyptus Drops (Halls®) Versus Reduced Volume Ascorbic Acid Supplemented PEG-Electrolyte (MoviPrep®) in Colonoscopy Preparation: A Randomised Controlled Study Completed NCT01788709 Phase 4
4 A Prospective, Double-blind, Randomized, and Controlled Clinical Trial to Compare the Effectiveness of Intravenous Bezlotoxumab (10 mg/kg) Versus Placebo in Decreasing Morbidity and Mortality in Patients With Fulminant Clostridioides Difficile Requiring Surgical Intervention. Recruiting NCT03756454 Phase 4
5 CSP #596 - Optimal Treatment for Recurrent Clostridium Difficile Infection Active, not recruiting NCT02667418 Phase 4 Fidaxomicin;Vancomycin with Taper/Pulse;Vancomycin
6 Peri-anal Local Anaesthetic Infiltration Versus Caudal Anaesthesia for Post-operative Pain Relief in Trans-anal Pull Through Operation for Hirschsprung's Disease. Not yet recruiting NCT04367818 Phase 4
7 Transplantation of Fecal Microbiota for Clostridium Difficile Infection Unknown status NCT01958463 Phase 3
8 A Randomized Prospective Trial Comparing Different Regimens of Polyethylene Glycol-based Lavage and Sodium Picosulphate With Magnesium Citrate in the Preparation of Patients for Colonoscopy Completed NCT01778192 Phase 3 Polyethylene glycol;Polyethylene glycol;Sodium picosulphate with magnesium citrate;Sodium picosulphate with magnesium citrate
9 Efficacy, Safety and Tolerability of Split-dose of PEG Compared With NaP Solution for Colonoscopy Preparation: A Randomized, Controlled Trial Completed NCT01229800 Phase 3 Polyethylene glycol;Sodium phosphate(NaP) solution
10 Aquanet Bowel Cleansing Device Versus Oral Sodium Picosulfate for Pre-endoscopy Bowel Preparation: Propensity Score Analysis for Interventional Effectiveness Evaluation Completed NCT03074448 Phase 3 Sodium Picosulfate
11 A Feasibility Randomized Trial of Intestinal Lavage for the Treatment of Severe C. Difficile Infections Recruiting NCT02466698 Phase 2, Phase 3 Vancomycin;PEG;Metronidazole
12 CSP #2004 - Microbiota or Placebo After Antimicrobial Therapy for Recurrent C. Difficile at Home (MATCH) Active, not recruiting NCT03005379 Phase 2, Phase 3 Fecal Microbiota Therapy (FMT);Placebo
13 Polyp Detection With The Peerscope System™: A Randomized Tandem Colonoscopy Study Completed NCT01549535 Phase 2
14 MANAGEMENT OF THE PATIENT WITH ACUTE ABDOMEN SUBMITTED TO URGENT ABDOMINAL SURGERY: a Pilot Randomized Multicentre Study Completed NCT01911702 Phase 2
15 Role of Intestinal Protozoa and Helminths in the Course of Ulcerative Colitis Active, not recruiting NCT03441893 Phase 1, Phase 2 Nitazoxanide 500Mg Oral Tablet;Mesalazine 250Mg Tablet and nitazoxanide 500Mg Oral Tablet;Mesalazine 250Mg
16 Incidence and Economic Burden of Community and Hospital- Acquired Clostridium Difficile Infections (CDI) in the German Health Care System (IBIS) Unknown status NCT03141775
17 Endomicroscopy for Assessment of Structural and Functional Changes in IBD Patients Treated With Anti-TNFalpha - Insights in the Process in Mucosal Healing Unknown status NCT01417728
18 Antimicrobial Stewardship Program Based on the Detection and Monitoring of Patients With Clostridium Difficile Infection (PACTA-ICD) Unknown status NCT02951481
19 Abdominal SepsiS Study: Epidemiology of Etiology and Outcome Completed NCT02442596
20 Factors Associated With Relapses in Patients Suffering From Clostridium Difficile Infection: Immune Response Completed NCT02440438
21 Determination of Genetic Polymorphisms in Chronic Chagas Cardiomyopathy Completed NCT02346123
22 A Randomized Prospective Trial Comparing Single Dose Polyethylene Glycol-based Lavage Versus Split Dose Polyethylene Glycol-based Lavage in the Preparation of Patients Undergoing Colonoscopy Completed NCT01610856 Polyethylene Glycol;polyethylene glycol
23 Efficacy and Safety of Golimumab in Maintaining Deep Remission and Quality of Life in Ulcerative Colitis Patients in Deep Prolonged Remission With Infliximab. An Open Label, Non Interventional One Year Study. Completed NCT02868398
24 A Proposed Physical Activity and Diet Control to Manage Constipation in Middle Age Obese Women Completed NCT03106857
25 Genetics of Hirschsprung's Disease - Can Genetic Mosaicism Due to Early Somatic Mutations, Explain Disease Development? Recruiting NCT01927809
26 A Prospective, Randomized Controlled Trial of Conservative Versus Surgery Treatment of Children With Hirschsprung Allied Disease Recruiting NCT02212054
27 The Enteric Nervous System as Modulator of Mucosal Immune Cells Recruiting NCT03617640
28 Incidence, Clinical Characteristics, Strain Characterization, Treatment and Outcome of Clostridium Difficile Infection (CDI) in Hematologic Patients Recruiting NCT03964844
29 Effect of Adding Simethicone to a Split Regimen of Polyethylene Glycol for Bowel Preparation in a Colorectal Cancer Screening Colonoscopy Setting: an Endoscopist-blinded Randomized Controlled Trial Recruiting NCT03816774 PEG split-dose and simethicone
30 Oligosaccharide Supplementation Among Hematology-Oncology Clostridium Difficile Colonized Patients Recruiting NCT03778606
31 Identification of Genetic, Immunologic and Microbial Markers of Hirschsprung Associated Enterocolitis in Children With Hirschsprung Disease Recruiting NCT02193685
32 Retrospective, Uncontrolled Multcentric Cohort Study on the Therapy of Chronic Megalon (CoMeC) Not yet recruiting NCT04340856 Laxatives
33 Efficacy and Safety of Fecal Microbiota Transplantation for Severe Clostridium Difficile Associated Colitis Terminated NCT01959048 fecal microbiota transplantation

Search NIH Clinical Center for Megacolon

Cochrane evidence based reviews: megacolon

Genetic Tests for Megacolon

Anatomical Context for Megacolon

MalaCards organs/tissues related to Megacolon:

40
Colon, Smooth Muscle, Thyroid, Testes, Small Intestine, Heart, Kidney

Publications for Megacolon

Articles related to Megacolon:

(show top 50) (show all 2685)
# Title Authors PMID Year
1
Acetylcholinesterase staining for the pathological diagnosis of Hirschsprung's disease. 61
32577882 2020
2
A case of severe megacolon due to acquired isolated hypoganglionosis after low anterior resection for lower rectal cancer. 61
31828729 2020
3
Total proctocolectomy with end ileostomy for acute onset of ulcerative colitis during chemoradiotherapy for lung adenocarcinoma (successfully treated by surgery): a case report. 61
32488431 2020
4
Salmonella colitis with perforation in the absence of toxic megacolon. 61
32526078 2020
5
The mechanisms and safety of probiotics against toxigenic clostridium difficile. 61
32520637 2020
6
Constipation screening in people taking clozapine: A diagnostic accuracy study. 61
32245597 2020
7
Synthetic carboline compounds targeting protein: biophysical and biological perspective. 61
32410501 2020
8
Harmful Algal Bloom Toxicity in Lithobates catesbeiana Tadpoles. 61
32521650 2020
9
From Nursery to Nursing Home: Emerging Concepts in Clostridioides difficile Pathogenesis. 61
32122939 2020
10
Megacolon Complicating Ulcerative Colitis and Clostridiodes Infection. 61
32448498 2020
11
Toxic megacolon due to Salmonella acute infectious colitis requiring total colectomy following loop ileostomy closure. 61
32396679 2020
12
Systematic Review: Clinical Utility of Gastrointestinal Ultrasound in the Diagnosis, Assessment and Management of Patients With Ulcerative Colitis. 61
31562739 2020
13
Mega-megacolon: a case report. 61
32447480 2020
14
Comparison of Barium Enema and frozen section results in the diagnosis of Hirschsprung's Disease in a tertiary care hospital at Aceh, Indonesia. 61
32471967 2020
15
Megacolon in the context of long-standing Cushing syndrome. 61
32444276 2020
16
Megacolon with infectious etiology that is infrequent in our country: Chagas disease. 61
32338024 2020
17
Amoebic toxic megacolon with poly-helminthic coinfection: Case presentation and review of intestinal polyparasitic infections. 61
32450374 2020
18
Highly antimicrobial-resistant Nontyphoidal Salmonella from retail meats and clinical impact in children, Taiwan. 61
32340872 2020
19
Laparoscopic-assisted colectomy with Duhamel procedure for idiopathic megacolon in adults: a retrospective study. 61
32267630 2020
20
The Clinical Drug Ebselen Attenuates Inflammation and Promotes Microbiome Recovery in Mice after Antibiotic Treatment for CDI. 61
32483557 2020
21
Updated Management Guidelines for Clostridioides difficile in Paediatrics. 61
32316346 2020
22
Current Diagnostic and Therapeutic Approaches to Cytomegalovirus Infections in Ulcerative Colitis Patients Based on Clinical and Basic Research Data. 61
32244555 2020
23
Clostridioides difficile Spores: Bile Acid Sensors and Trojan Horses of Transmission. 61
32104157 2020
24
Fecal microbiota transplantation is feasible even in critically ill patients with toxic megacolon due to Clostridium difficile infection. 61
32200611 2020
25
Enteric Nervous System: lessons from neurogenesis for reverse engineering and disease modelling and treatment. 61
32240931 2020
26
Campylobactercolitis leads to toxic megacolon and multiple organ failure. 61
32205380 2020
27
The Management of the Hospitalized Ulcerative Colitis Patient: the Medical-Surgical Conundrum. 61
32040642 2020
28
Megacolon in inflammatory bowel disease: response to infliximab. 61
31960698 2020
29
Cytomegalovirus ileo-pancolitis presenting as toxic megacolon in an immunocompetent patient: A case report. 61
32110666 2020
30
Third Space Endoscopy: Lessons Learnt From a Decade of Submucosal Endoscopy. 61
31851106 2020
31
Microbe-microbe interactions during Clostridioides difficile infection. 61
32088581 2020
32
Clostridioides difficile Infection: Update on Management. 61
32003951 2020
33
Predictors of Clostridioides difficile Infection-Related Complications and Treatment Patterns among Nucleic Acid Amplification Test-Positive/Toxin Enzyme Immunoassay-Negative Patients. 61
31896665 2020
34
Clostridioides difficile infection in the Asia-Pacific region. 61
31873046 2020
35
Massive Hydrothorax and Ascites as the Primary Manifestation of Infection With Clostridium difficile: A Case Report and Literature Review. 61
32509714 2020
36
[Three cases of severe and fulminating ulcerative colitis with megacolon treated with continuous intravenous infusion of cyclosporine]. 61
32037361 2020
37
A case with cytomegalovirus colitis and toxic megacolon initially diagnosed as Crohn's disease. 61
31973935 2020
38
Concurrent Hirschsprung's disease and anorectal malformation: a systematic review. 61
31552492 2020
39
Waardenburg-Shah syndrome (WS type IV): a rare case from Pakistan. 61
31998473 2020
40
Toxic Megacolon: Background, Pathophysiology, Management Challenges and Solutions. 61
32547151 2020
41
Precision Health for Chagas Disease: Integrating Parasite and Host Factors to Predict Outcome of Infection and Response to Therapy. 61
32457849 2020
42
Acquired segmental sigmoid hypoganglionosis: A case report. 61
31977872 2020
43
Severe Postoperative Chronic Constipation Related to Anorectal Malformation Managed with Osteopathic Manipulative Treatment. 61
32399006 2020
44
Biological characteristics associated with virulence in Clostridioides difficile ribotype 002 in Hong Kong. 61
32183606 2020
45
Growing consumption of antibiotics and epidemiology of Clostridioides difficile infections in Poland: A need to develop new solutions. 61
31813263 2019
46
Lymphocytic ganglionitis leading to megacolon in lymphocyte-rich glioblastoma. 61
31655421 2019
47
Megacolon as the presenting feature of multiple endocrine neoplasia type 2B: a case report. 61
32127501 2019
48
Colonic Manifestations and Complications Are Relatively Under-Reported in Systemic Sclerosis: A Systematic Review. 61
31805016 2019
49
A comprehensive review and update on ulcerative colitis. 61
30837080 2019
50
Dr. Orvar Swenson and the Pull-Through. 61
31912779 2019

Variations for Megacolon

Expression for Megacolon

Search GEO for disease gene expression data for Megacolon.

Pathways for Megacolon

Pathways related to Megacolon according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.62 TLX2 SOX10 PHOX2B
2
Show member pathways
11.58 RET PSPN NRTN GFRA1 GDNF
3 11.44 SOX10 GDNF CHAT
4 10.91 RET GFRA1 GDNF
5
Show member pathways
10.8 CHAT ACHE
6 10.49 PSPN NRTN GFRA1 GDNF
7 10.48 CHAT ACHE
8 10.17 CHAT ACHE
9 9.91 RET GFRA1 GDNF

GO Terms for Megacolon

Biological processes related to Megacolon according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.85 ZEB2 RET PSPN PHOX2B NRTN KIFBP
2 MAPK cascade GO:0000165 9.83 RET PSPN NRTN GFRA1 GDNF
3 axon guidance GO:0007411 9.73 SEMA3F RET PSPN NRTN GFRA1 GDNF
4 response to pain GO:0048265 9.58 RET EDNRB
5 vasoconstriction GO:0042310 9.58 EDNRB EDN3
6 peripheral nervous system development GO:0007422 9.58 SOX10 GDNF EDNRB
7 sympathetic nervous system development GO:0048485 9.57 PHOX2B GDNF
8 nerve development GO:0021675 9.56 SEMA3F NRTN
9 neurotransmitter biosynthetic process GO:0042136 9.55 CHAT ACHE
10 developmental pigmentation GO:0048066 9.54 ZEB2 EDNRB
11 sympathetic ganglion development GO:0061549 9.52 SEMA3F PHOX2B
12 glial cell-derived neurotrophic factor receptor signaling pathway GO:0035860 9.51 RET GFRA1
13 melanocyte differentiation GO:0030318 9.5 SOX10 EDNRB EDN3
14 neural crest cell migration involved in autonomic nervous system development GO:1901166 9.49 SEMA3F PHOX2B
15 positive regulation of penile erection GO:0060406 9.48 VIP EDNRB
16 vein smooth muscle contraction GO:0014826 9.46 EDNRB EDN3
17 enteric nervous system development GO:0048484 9.43 TLX2 SOX10 RET PHOX2B GDNF EDNRB
18 posterior midgut development GO:0007497 9.37 RET EDNRB
19 neural crest cell migration GO:0001755 9.23 ZEB2 SOX10 SEMA3F RET NRTN GDNF

Molecular functions related to Megacolon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.02 PSPN NRTN GFRA1 GDNF EDN3

Sources for Megacolon

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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