MCID: MGS001
MIFTS: 44

Megaesophagus

Categories: Gastrointestinal diseases

Aliases & Classifications for Megaesophagus

MalaCards integrated aliases for Megaesophagus:

Name: Megaesophagus 12 15 70
Esophageal Achalasia 44 70

Classifications:



External Ids:

Disease Ontology 12 DOID:13186
MeSH 44 D004931
NCIt 50 C34811
SNOMED-CT 67 70667005
UMLS 70 C0014848 C0025164

Summaries for Megaesophagus

MalaCards based summary : Megaesophagus, also known as esophageal achalasia, is related to barrett esophagus and in situ carcinoma. An important gene associated with Megaesophagus is FHIT (Fragile Histidine Triad Diadenosine Triphosphatase), and among its related pathways/superpathways are Phospholipase-C Pathway and Glioma. The drugs Methylene blue and Atropine have been mentioned in the context of this disorder. Affiliated tissues include colon, heart and liver, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 73 Megaesophagus, also known as esophageal dilatation, is a disorder of the esophagus in humans and other... more...

Related Diseases for Megaesophagus

Diseases related to Megaesophagus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 322)
# Related Disease Score Top Affiliating Genes
1 barrett esophagus 30.1 TP53 MYC FHIT CDKN2A
2 in situ carcinoma 29.9 TP53 MYC CDKN2A
3 leiomyosarcoma 29.9 TP53 MYC CDKN2A
4 rhabdomyosarcoma 29.2 TP53 PAX7 MYC FGFR1 CDKN2A
5 achalasia, familial esophageal 11.5
6 achalasia 10.7
7 chagas disease 10.6
8 dysphagia 10.6
9 megacolon 10.4
10 esophagitis 10.4
11 vulvar intraepithelial neoplasia 10.4 TP53 CDKN2A
12 esophagus verrucous carcinoma 10.3 TP53 CDKN2A
13 ovarian seromucinous carcinoma 10.3 TP53 CDKN2A
14 spitz nevus 10.3 TP53 CDKN2A
15 anal carcinoma in situ 10.3 TP53 MYC
16 squamous cell papilloma 10.3 TP53 CDKN2A
17 penile benign neoplasm 10.3 TP53 CDKN2A
18 bizarre leiomyoma 10.3 TP53 CDKN2A
19 adult malignant schwannoma 10.3 TP53 CDKN2A
20 frontal lobe neoplasm 10.3 TP53 MYC
21 supraglottis cancer 10.3 TP53 CDKN2A
22 b cell prolymphocytic leukemia 10.3 TP53 MYC
23 vulva basal cell carcinoma 10.3 MYC CDKN2A
24 spinal cord oligodendroglioma 10.3 TP53 FGFR1
25 localized osteosarcoma 10.3 TP53 CDKN2A
26 malignant exocrine pancreas neoplasm 10.3 TP53 CDKN2A
27 primary cutaneous diffuse large b-cell lymphoma, leg type 10.3 MYC CDKN2A
28 chronic cervicitis 10.3 TP53 CDKN2A
29 thyroid lymphoma 10.3 TP53 CDKN2A
30 bladder clear cell adenocarcinoma 10.3 TP53 CDKN2A
31 keratocystic odontogenic tumor 10.3 TP53 FHIT
32 keratinizing squamous cell carcinoma 10.3 TP53 CDKN2A
33 plasmablastic lymphoma 10.3 MYC CDKN2A
34 male reproductive organ benign neoplasm 10.3 TP53 CDKN2A
35 malignant spiradenoma 10.3 TP53 CDKN2A
36 bile duct adenoma 10.3 TP53 CDKN2A
37 vulva squamous cell carcinoma 10.3 TP53 CDKN2A
38 vaginal cancer 10.3 TP53 CDKN2A
39 esophageal cancer 10.3
40 aspiration pneumonia 10.3
41 gum cancer 10.3 TP53 MYC
42 human papillomavirus infectious disease 10.2 TP53 FHIT CDKN2A
43 nasal cavity adenocarcinoma 10.2 TP53 CDKN2A
44 uterus carcinoma in situ 10.2 TP53 FHIT CDKN2A
45 cervix uteri carcinoma in situ 10.2 TP53 FHIT CDKN2A
46 bone squamous cell carcinoma 10.2 TP53 CDKN2A
47 muir-torre syndrome 10.2 TP53 FHIT CDKN2A
48 low-grade astrocytoma 10.2 TP53 CDKN2A
49 bilateral breast cancer 10.2 TP53 FHIT CDKN2A
50 lung benign neoplasm 10.2 TP53 FHIT CDKN2A

Comorbidity relations with Megaesophagus via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Deficiency Anemia Dyskinesia of Esophagus
Esophageal Disease Esophagitis
Heart Disease Protein-Energy Malnutrition
Swallowing Disorders

Graphical network of the top 20 diseases related to Megaesophagus:



Diseases related to Megaesophagus

Symptoms & Phenotypes for Megaesophagus

MGI Mouse Phenotypes related to Megaesophagus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.13 ARHGEF10 CDKN2A CDON COL19A1 FGFR1 MYC
2 homeostasis/metabolism MP:0005376 10.11 ARHGEF1 ARHGEF10 CDKN2A FGFR1 FHIT MYC
3 immune system MP:0005387 10.02 ARHGEF1 CD8A CDKN2A FGFR1 FHIT MYC
4 digestive/alimentary MP:0005381 10.01 CDKN2A CDON COL19A1 FGFR1 FHIT MYC
5 mortality/aging MP:0010768 9.93 ARHGEF1 CD8A CDKN2A CDON COL19A1 FGFR1
6 integument MP:0010771 9.91 CD8A CDKN2A COL19A1 FGFR1 FHIT MYC
7 muscle MP:0005369 9.5 ARHGEF1 CDKN2A COL19A1 FGFR1 MYC PAX7
8 nervous system MP:0003631 9.32 ARHGEF10 CD8A CDKN2A CDON FGFR1 MYC

Drugs & Therapeutics for Megaesophagus

Drugs for Megaesophagus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylene blue Approved, Investigational Phase 4 61-73-4
2
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
3
Edrophonium Approved Phase 4 116-38-1, 312-48-1 3202
4
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
5
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
6
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
7
Remifentanil Approved Phase 4 132875-61-7 60815
8
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
9 Anti-Arrhythmia Agents Phase 4
10 Antidotes Phase 4
11 Respiratory System Agents Phase 4
12 Anti-Asthmatic Agents Phase 4
13 Mydriatics Phase 4
14 Muscarinic Antagonists Phase 4
15 Parasympatholytics Phase 4
16 Protective Agents Phase 4
17 Cholinesterase Inhibitors Phase 4
18 Bronchodilator Agents Phase 4
19 Cholinergic Antagonists Phase 4
20 abobotulinumtoxinA Phase 4
21 Cholinergic Agents Phase 4
22 Botulinum Toxins Phase 4
23 Botulinum Toxins, Type A Phase 4
24 Anti-Inflammatory Agents Phase 4
25 glucocorticoids Phase 4
26 Hormone Antagonists Phase 4
27 Hormones Phase 4
28 Antineoplastic Agents, Hormonal Phase 4
29 Anesthetics Phase 4
30 Analgesics Phase 4
31 Narcotics Phase 4
32 Analgesics, Opioid Phase 4
33 Anesthetics, General Phase 4
34 Anesthetics, Intravenous Phase 4
35
Ceftazidime Approved Phase 2, Phase 3 78439-06-2, 72558-82-8 5481173
36 Tin Fluorides Phase 3
37 Antibiotics, Antitubercular Phase 3
38 Anti-Bacterial Agents Phase 3
39 Anti-Infective Agents Phase 3
40
Nitric Oxide Approved Phase 1, Phase 2 10102-43-9 145068
41 Cola Phase 2
42
Cefazolin Approved 25953-19-9 33255 656510
43
Amoxicillin Approved, Vet_approved 26787-78-0 33613
44
Ropivacaine Approved 84057-95-4 71273 175805
45
Formaldehyde Approved, Vet_approved 50-00-0 712
46
Dopamine Approved 62-31-7, 51-61-6 681
47
Domperidone Approved, Investigational, Vet_approved 57808-66-9 3151
48
Esomeprazole Approved, Investigational 161973-10-0, 161796-78-7, 119141-88-7 4594 9568614
49
Mirabegron Approved Early Phase 1 223673-61-8 9865528
50 Cephalosporins

Interventional clinical trials:

(show top 50) (show all 92)
# Name Status NCT ID Phase Drugs
1 Personalized Peroral Endoscopic Myotomy for Achalasia Unknown status NCT01570621 Phase 4
2 Comprehensive Assessment of Histopathologic and Physiologic Profile in Esophageal Motility Disorders Recruiting NCT04641702 Phase 4 Edrophonium challenge;Atropine challenge
3 Prospective Single-Blinded Randomized Controlled Trial Comparing Botox or Botox With Esophageal Dilation in Patients With Achalasia Enrolling by invitation NCT03654066 Phase 4 Botulinum toxin type A
4 A Pilot Study Assessing the Efficacy of Steroids in the Treatment of Achalasia Enrolling by invitation NCT01903486 Phase 4 Apo-Prednisone Cordorol, Detasone - Prednisone
5 Influence of Intraoperative Opioids (Oxycodone/Fentanyl) Usage on the Post-operative Pain Management of Peroral Endoscopic Myotomy (POEM) Not yet recruiting NCT04177342 Phase 4 Fentanyl;Oxycodone
6 Single- Versus Multiple-dose Antimicrobial Prophylaxis for The Prevention of Infectious Complications Associated With Peroral Endoscopic Myotomy(POEM) for Achalasia: A Triple-Blind, Randomized Controlled, Non-Inferiority Trial Unknown status NCT03404739 Phase 2, Phase 3 Saline Solution;Ceftazidime
7 Peroral Endoscopic Myotomy for Primary Esophageal Achalasia Completed NCT01560559 Phase 3
8 Randomized Control Study Comparing Single-Versus Multiple-dose Antimicrobial Prophylaxis for Peroral Endoscopic Myotomy in Achalasia Recruiting NCT03784365 Phase 3 One dose of Cefo-perazone Sulbactum
9 Efficacy of Dark Chocolate in Achalasia Patients: Placebo-Controlled Study Unknown status NCT00790465 Phase 1, Phase 2
10 Endoscopic Submucosal Tunnel Dissection for Endolumenal Partial Myotomy of the Lower Esophageal Sphincter for Achalasia Unknown status NCT01302288 Phase 2
11 Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Primary Esophageal Motility Disorders Unknown status NCT01524471 Phase 2
12 Endoscopic Esophageal Myotomy for the Treatment of Achalasia Completed NCT01873300 Phase 1, Phase 2
13 Prospective Study on the Feasibility and Results of the Treatment of Idiopathic Achalasia With the POEM (Per Oral Endoscopic Myotomy) Technique Completed NCT02259283 Phase 2
14 Peroral Endoscopic Myotomy (POEM) for the Treatment of Achalasia Completed NCT02073578 Phase 1, Phase 2
15 A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Single-dose, Phase 2a Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IW-1701 in Patients With Achalasia Completed NCT02931565 Phase 2 IW-1701;Matching Placebo
16 Randomized Study to Compare Pneumatic Dilatation With Surgical Myotomy for Treatment of Achalasia - Long Term Follow up Completed NCT02086669 Phase 2
17 Peroral Endoscopic Myotomy Versus Pneumatic Dilation for Esophageal Achalasia: a Prospective Randomized Controlled Trial Unknown status NCT01768091
18 Peroral Endoscopic Myotomy for Esophageal Achalasia: Randomized Comparison of Water-Jet Assisted Versus Conventional Dissection Technique Unknown status NCT01742494
19 Clinical Impact of Peroral Endoscopic Myotomy for Esophageal Achalasia Unknown status NCT01649843
20 Bacteremia and Procalcitonin Levels in Peroral Endoscopic Myotomy for Achalasia Unknown status NCT01750385 no antibiotic prophylaxis;second-generation cephalosporin
21 A Randomized Comparison of Laparoscopic Myotomy and Pneumatic Dilatation for Achalasia Unknown status NCT00188344
22 to Explore the Influence of Longitudinal Muscle on the Prognosis of Achalasia Patients After Peroral Endoscopic Myotomy Unknown status NCT03733756
23 To Assess the Feasibility of Same Day Discharge Following a POEM Procedure Unknown status NCT02572193
24 Endoscopic Submucosal Tunnel Dissection for Endoluminal Partial Myotomy of the Lower Esophageal Sphincter in Patients With Spastic Esophageal Disorders Such as Achalasia Unknown status NCT02425033
25 Peroral Endoscopic Remyotomy for Failed Heller Myotomy Unknown status NCT01637311
26 Efficacy and Safety Study of Hot Water Drinking Therapy in Achalasia Patients Unknown status NCT01863966
27 Clinical Outcomes of Peroral Endoscopic Myotomy for Esophageal Outflow Obstruction Unknown status NCT02989883
28 Randomised Clinical Trial Comparing Relief of Dysphagia Between Laparoscopic Heller's Myotomy Alone Versus Laparoscopic Heller's Myotomy With Anterior Fundoplication In Achalasia Cardia-A Pilot Study Unknown status NCT03438838
29 Screening for Dysplasia in Longstanding Idiopathic Achalasia: a Prospective Study Unknown status NCT02010983
30 A Prospective Trial Comparing POEM to Pneumatic Dilatation for Treatment of Achalasia Cardia Unknown status NCT02025790
31 Peroral Endoscopic Myotomy (POEM) For The Treatment Of Achalasia: A Retrospective And Prospective Multicenter Registry. Unknown status NCT02162589
32 Achalasia; Mechanisms Underlying Persistent Symptoms After Treatment Unknown status NCT02055469
33 Laparoscopy Heller Myotomy With Fundoplication Associated Versus Peroral Endoscopic Myotomy (POEM) Unknown status NCT02138643
34 Short and Long Term Outcomes of Heller Myotomy Unknown status NCT00519220
35 Randomized Prospective Trial of Laparoscopic Heller Myotomy and Partial Fundoplication for the Treatment of Idiopathic Esophageal Achalasia Completed NCT00490750
36 Safety, Efficacy and Cost-effectiveness of Snare-assisted POEM for Treatment of Esophageal Achalasia Completed NCT02999451
37 Randomized Study of Botulinum Toxin Type A for Achalasia Completed NCT00004416 botulinum toxin type A
38 Risk of Microbial Translocation in Patients Undergoing Per-Oral Endoscopic Myotomy (POEM) for Achalasia: Antibiotic Prophylaxis or Short-therapy Completed NCT03587337
39 Comparison of Short Versus Long Oesophageal Myotomy in Cases With Idiopathic Achalasia: A Randomized Single Blinded Trial Completed NCT03186248
40 Evaluation of a Novel Endoscopic Treatment for Achalasia: Per-oral Endoscopic Esophagomyotomy (POEM) Completed NCT01770249
41 A Prospective, Single Center, Proof of Concept Pilot Study of the Efficacy and Safety of Submucosal Endoscopic Myotomy With Mucosal Flap (SEMF) Technique in the Treatment of Patients With Achalasia Completed NCT01438398
42 Impact of Antibiotic Prophylaxis and Conditioning Modalities in Per Oral Endoscopic Myotomy for Esophageal Motor Disorders Completed NCT03944863 Antibiotics
43 Peroral Endoscopic Myotomy (POEM) for Esophageal Motility in Patients With a Clinical Diagnosis of Achalasia Completed NCT02314741
44 Prospective Evaluation of a New Approach to Perform an Esophageal Myotomy: the Transesophageal Submucosa Approach Completed NCT02773589
45 Ropivacaine For Post-POEM Pain Control Completed NCT03702647 Ropivacaine;Normal saline
46 Observational Study of the Per-Oral Endoscopic Myotomy (POEM) Procedure Completed NCT01402518
47 Peroral Endoscopic Myotomy (POEM) for Treatment of Achalasia Completed NCT01584635
48 Prospective Study on the Feasibility and Effectiveness of Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Primary Esophageal Motility Disorders Completed NCT01525732
49 A Prospective Randomized Trial Comparing Two Reconstructive Operation Techniques After Myotomy of Achalasia. Comparing Toupet Versus DOR. Completed NCT01933373
50 A Clinical Study of Per Oral Endoscopic Myotomy (POEM) in Patients Suffering From Achalasia. Completed NCT01692106

Search NIH Clinical Center for Megaesophagus

Cochrane evidence based reviews: esophageal achalasia

Genetic Tests for Megaesophagus

Anatomical Context for Megaesophagus

MalaCards organs/tissues related to Megaesophagus:

40
Colon, Heart, Liver, Smooth Muscle, Small Intestine, Pancreas, Thyroid

Publications for Megaesophagus

Articles related to Megaesophagus:

(show top 50) (show all 1522)
# Title Authors PMID Year
1
A case of esophageal achalasia presenting with empyema and septic shock differentiated from esophageal rupture. 61
33527334 2021
2
Fibromyalgia associated with Chagas' disease treated with nutraceuticals. 61
33745580 2021
3
Advanced achalasia: good candidate for peroral endoscopic myotomy. 61
33693695 2021
4
Laparoscopic Heller Myotomy and Dor Fundoplication for the Treatment of Esophageal Achalasia After Sleeve Gastrectomy-a Video Vignette. 61
33231820 2021
5
Influence of esophageal morphology on the clinical efficacy of peroral endoscopic myotomy in treating advanced achalasia cardia. 61
33488805 2021
6
Long-term clinical results of per-oral endoscopic myotomy (POEM) for achalasia: First report of more than 10-year patient experience as assessed with a questionnaire-based survey. 61
33655041 2021
7
The etiology of achalasia: An immune-dominant disease. 61
33583137 2021
8
Effects of the preoperative IRP values on the pathophysiology of patients with esophageal achalasia and on the treatment outcome of laparoscopic Heller-Dor surgery. 61
33604819 2021
9
SAGES guidelines for the use of peroral endoscopic myotomy (POEM) for the treatment of achalasia. 61
33564964 2021
10
Postoperative pregnancy in female achalasia patients: Report of three cases. 61
33517212 2021
11
Multicenter Evaluation with Eckardt Score of Laparoscopic Management with Heller Myotomy and Dor Fundoplication for Esophageal Achalasia in a Pediatric Population in Colombia. 61
33560184 2021
12
Sigmoid megaesophagus with thoracic pseudotumor appearance. 61
32684331 2021
13
A Rare Case of a Life-Threatening Massive Upper Gastrointestinal Bleed and Airway Obstruction in a Patient With a Megaesophagus Secondary to Longstanding Achalasia. 61
33717744 2021
14
Automatic classification of canine thoracic radiographs using deep learning. 61
33597566 2021
15
Megaesophagus and Megaduodenum Found Incidentally on a Routine Chest Radiograph During a Health Examination. 61
33518569 2021
16
SEVERE RESPIRATORY FAILURE SECONDARY TO MEGAOESOPHAGUS DUE TO TERMINAL ACHALASIA. 61
33393337 2021
17
Sigmoid megaesophagus as clinical presentation of achalasia. 61
33494877 2021
18
Laparoscopic Heller Myotomy and Roux-en-Y Gastric Bypass as Treatment for Patients with Achalasia and Morbid Obesity: Outcomes in a Short Series of Patients. 61
32552364 2021
19
Cutting-Edge Technologies for Gastrointestinal Therapeutic Endoscopy. 61
33692281 2021
20
Clinical correlation and disease phenotype in patients with esophageal achalasia and comorbid autoimmune diseases. 61
32766709 2021
21
Autophagy-related 16-like 1 is influenced by human herpes virus 1-encoded microRNAs in biopsy samples from the lower esophageal sphincter muscle during per-oral endoscopic myotomy for esophageal achalasia. 61
33235722 2021
22
The evaluation of the dilation-degree classification of esophageal achalasia patients from the viewpoint of esophageal clearance. 61
33387027 2021
23
Esophagobronchial fistula complicated by esophageal achalasia treated by per-oral endoscopic myotomy. 61
32909156 2020
24
Prion Gene PRNP Y162X Truncation Mutation Can Induce a Refractory Esophageal Achalasia. 61
33149002 2020
25
Transient Megaesophagus Following Coral Snake Envenomation in Three Dogs (2013-2018). 61
33113557 2020
26
End-stage Esophageal Achalasia as Incidental Finding After Thoracic Trauma. 61
32005327 2020
27
The Malnutrition Universal Screening Tool can predict malnutrition in patients with esophageal achalasia. 61
32541242 2020
28
Innovative therapeutic endoscopy in the upper gastrointestinal tract: Review of Japan Gastroenterological Endoscopic Society Core Sessions. 61
32415998 2020
29
Long-term outcome of Miniature Schnauzers with genetically confirmed demyelinating polyneuropathy: 12 cases. 61
32738000 2020
30
Long-term Outcomes of Laparoscopic Heller's Cardiomyotomy in Achalasia Cardia With Megaesophagus. 61
32890251 2020
31
Polyneuropathy in Young Siberian Huskies Caused by Degenerative and Inflammatory Diseases. 61
32578500 2020
32
[Continue to strengthen the study on diagnosis and surgical treatment of primary esophageal motility disorders and gastroesophageal reflux diseases]. 61
32878411 2020
33
Clinical decision making and application of an active rehabilitation program for a person with the neuromuscular symptoms of Allgrove syndrome: a case report. 61
30501443 2020
34
Laparoscopic surgery for ventrally located epiphrenic diverticulum with esophageal achalasia. 61
32232772 2020
35
Surgical management of achalasia. 61
32724877 2020
36
The relationship between the interruption of the lower esophageal sphincter and relief of dysphagia after per-oral endoscopic myotomy for achalasia. 61
32611850 2020
37
Gastric myotomy length affects severity but not rate of post-procedure reflux: 3-year follow-up of a prospective randomized controlled trial of double-scope per-oral endoscopic myotomy (POEM) for esophageal achalasia. 61
31463720 2020
38
Mapping of host-parasite-microbiome interactions reveals metabolic determinants of tropism and tolerance in Chagas disease. 61
32766448 2020
39
Medical considerations in delusion of pregnancy: a systematic review. 61
32597281 2020
40
Per oral endoscopic myotomy (POEM) in pediatric patients with esophageal achalasia: First Latin-American experience. 61
32646661 2020
41
Quality of Life Following Peroral Endoscopic Myotomy for Esophageal Achalasia: A Systematic Review and Meta-Analysis. 61
32132346 2020
42
Antireflux Surgery for Gastroesophageal Reflux Refractory to Medical Treatment After Peroral Endoscopic Myotomy. 61
32240031 2020
43
POEM for Esophageal Achalasia. 61
32315561 2020
44
Cardiovascular dynamics during peroral endoscopic myotomy for esophageal achalasia: a prospective observational study using non-invasive finger cuff-derived pulse wave analysis. 61
32504156 2020
45
Giant Esophageal Fibrolipoma and an End-Stage Megaesophagus due to Achalasia. 61
32684020 2020
46
Megacolon with infectious etiology that is infrequent in our country: Chagas disease. 61
32338024 2020
47
Characteristics and long-term outcomes of dogs with gastroesophageal intussusception. 61
32223709 2020
48
2019 Seoul Consensus on Esophageal Achalasia Guidelines. 61
32235027 2020
49
The Treatment of Esophageal Achalasia: At the Intersection Between Innovation and Patient's Care. 61
31895620 2020
50
Extended Esophageal Achalasia. 61
31735799 2020

Variations for Megaesophagus

Expression for Megaesophagus

Search GEO for disease gene expression data for Megaesophagus.

Pathways for Megaesophagus

GO Terms for Megaesophagus

Biological processes related to Megaesophagus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell cycle arrest GO:0007050 9.33 TP53 MYC CDKN2A
2 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.13 YES1 FGFR1 CD8A
3 replicative senescence GO:0090399 8.62 TP53 CDKN2A

Molecular functions related to Megaesophagus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 core promoter sequence-specific DNA binding GO:0001046 9.16 TP53 MYC
2 MDM2/MDM4 family protein binding GO:0097371 8.96 TP53 CDKN2A
3 Rho guanyl-nucleotide exchange factor activity GO:0005089 8.62 ARHGEF10 ARHGEF1

Sources for Megaesophagus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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