MCID: MBM001
MIFTS: 32

Meibomian Cyst

Categories: Eye diseases, Endocrine diseases

Aliases & Classifications for Meibomian Cyst

MalaCards integrated aliases for Meibomian Cyst:

Name: Meibomian Cyst 12 15 73
Chalazion 12 76 44
Meibomian Gland Lipogranuloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9903
ICD10 33 H00.1
ICD9CM 35 373.2
MeSH 44 D017043
NCIt 50 C26717
UMLS 73 C0007933

Summaries for Meibomian Cyst

Disease Ontology : 12 A blepharitis that is characterized as a cyst in the eyelid that is caused by inflammation of a blocked meibomian gland, usually on the upper eyelid.

MalaCards based summary : Meibomian Cyst, also known as chalazion, is related to eyelid neoplasm and internal hordeolum. An important gene associated with Meibomian Cyst is PIN1 (Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1), and among its related pathways/superpathways are FOXA1 transcription factor network and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs Loteprednol and Tobramycin have been mentioned in the context of this disorder. Affiliated tissues include eye.

Wikipedia : 76 Chalazion is a cyst in the eyelid due to a blocked oil gland. They are typically in the middle of the... more...

Related Diseases for Meibomian Cyst

Diseases related to Meibomian Cyst via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 eyelid neoplasm 30.7 KRT20 KRT7
2 internal hordeolum 10.9
3 cystic basal cell carcinoma 10.8 KRT20 KRT7
4 vaginal benign neoplasm 10.8 KRT20 KRT7
5 seminal vesicle adenocarcinoma 10.8 KRT20 KRT7
6 transverse colon cancer 10.7 KRT20 KRT7
7 appendix adenocarcinoma 10.7 KRT20 KRT7
8 ovarian large-cell neuroendocrine carcinoma 10.7 KRT20 KRT7
9 vaginal adenoma 10.7 KRT20 KRT7
10 vaginal tubulovillous adenoma 10.7 KRT20 KRT7
11 glandular cystitis 10.7 KRT20 KRT7
12 malignant syringoma 10.7 KRT20 KRT7
13 krukenberg carcinoma 10.7 KRT20 KRT7
14 large intestine adenocarcinoma 10.7 KRT20 KRT7
15 linitis plastica 10.7 KRT20 KRT7
16 lung acinar adenocarcinoma 10.7 KRT20 KRT7
17 small cell carcinoma of the bladder 10.7 KRT20 KRT7
18 adenoid squamous cell carcinoma 10.7 KRT20 KRT7
19 eccrine sweat gland neoplasm 10.7 KRT20 KRT7
20 mucinous bronchioloalveolar adenocarcinoma 10.7 KRT20 KRT7
21 intratubular embryonal carcinoma 10.7 KRT20 KRT7
22 ovarian mucinous adenocarcinoma 10.7 KRT20 KRT7
23 gastric diffuse adenocarcinoma 10.7 KRT20 KRT7
24 bladder lymphoma 10.7 KRT20 KRT7
25 papillary serous adenocarcinoma 10.7 KRT20 KRT7
26 bladder adenocarcinoma 10.7 KRT20 KRT7
27 jejunal adenocarcinoma 10.7 KRT20 KRT7
28 chronic cystitis 10.7 KRT20 KRT7
29 medulloepithelioma 10.7 KRT20 KRT7
30 glycogen-rich clear cell breast carcinoma 10.7 KRT20 KRT7
31 renal pelvis carcinoma 10.7 KRT20 KRT7
32 ampulla of vater neoplasm 10.7 KRT20 KRT7
33 appendix cancer 10.7 KRT20 KRT7
34 ampulla of vater adenocarcinoma 10.6 KRT20 KRT7
35 mucinous cystadenocarcinoma 10.6 KRT20 KRT7
36 lymphoepithelioma-like carcinoma 10.6 KRT20 KRT7
37 endocervical adenocarcinoma 10.6 KRT20 KRT7
38 dermoid cyst 10.6 KRT20 KRT7
39 morpheaform basal cell carcinoma 10.6 AR KRT20
40 cystadenofibroma 10.6 KRT20 KRT7
41 prostatic acinar adenocarcinoma 10.6 AR KRT20
42 cystic teratoma 10.6 KRT20 KRT7
43 horseshoe kidney 10.6 KRT20 KRT7
44 inverted papilloma 10.6 KRT20 KRT7
45 adenocarcinoma in situ 10.6 KRT20 KRT7
46 ovarian cystic teratoma 10.6 KRT20 KRT7
47 large cell neuroendocrine carcinoma 10.6 KRT20 KRT7
48 epithelial-myoepithelial carcinoma 10.6 KRT7 PLIN2
49 cecum adenocarcinoma 10.6 KRT20 KRT7
50 mammary paget's disease 10.5 KRT20 KRT7

Graphical network of the top 20 diseases related to Meibomian Cyst:



Diseases related to Meibomian Cyst

Symptoms & Phenotypes for Meibomian Cyst

Drugs & Therapeutics for Meibomian Cyst

Drugs for Meibomian Cyst (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loteprednol Approved Phase 4 82034-46-6, 129260-79-3 444025 9865442
2
Tobramycin Approved, Investigational Phase 4,Not Applicable 32986-56-4 5496 36294
3 Anti-Allergic Agents Phase 4
4 Anti-Bacterial Agents Phase 4,Not Applicable,Early Phase 1
5 Anti-Infective Agents Phase 4,Not Applicable,Early Phase 1
6
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
7
Fluorouracil Approved Phase 3 51-21-8 3385
8 triamcinolone acetonide Phase 3
9 glucocorticoids Phase 3
10 Hormone Antagonists Phase 3
11 Triamcinolone diacetate Phase 3
12 Triamcinolone hexacetonide Phase 3
13 Hormones Phase 3
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
15 Immunosuppressive Agents Phase 3
16 Anti-Inflammatory Agents Phase 3
17 Antimetabolites Phase 3
18 Antimetabolites, Antineoplastic Phase 3
19
Dexamethasone Approved, Investigational, Vet_approved Not Applicable 50-02-2 5743
20 Dexamethasone acetate Not Applicable 1177-87-3
21 BB 1101 Not Applicable
22 Central Nervous System Depressants Not Applicable
23 Anesthetics Not Applicable
24 Anesthetics, Local Not Applicable
25 Peripheral Nervous System Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pediatric Zylet Safety and Efficacy Study Completed NCT00420628 Phase 4 loteprednol etabonate/tobramycin opthalmic suspension;vehicle
2 Evaluation of Screening Methods for Treatment of Meibomian Gland Dysfunction Completed NCT01202747 Phase 2, Phase 3
3 Chalazia Treatment Study Recruiting NCT02025023 Phase 3 5-fluorouracil Injection;Triamcinolone Acetonide;Triamcinolone Acetonide/5-fluorouracil mixture
4 Safety and Efficacy Study of SUN-131 Transdermal System (TDS) as Compared to Placebo TDS in Patients With a Chalazion Recruiting NCT03248440 Phase 3 SUN-131 1.5% TDS;Placebo TDS
5 Safety and Efficacy Study of SUN 131 TDS as Compared to Placebo TDS in Adult Patients With a Chalazion Completed NCT02338648 Phase 2 SUN-131 1.5% TDS;Placebo TDS
6 Chalazion Conservative Treatment Trial Completed NCT01230593 Not Applicable Hot Compress plus Tobramycin Drops and Ointment;Hot compress plus Tobramycin/Dexamethasone Drops and Ointment
7 Treatment of Meibomian Gland Dysfunction and Evaporative Dry Eye Completed NCT00832130 Not Applicable
8 Clinical, Meibographic and Interferometric Evaluation of Phlyctenular Keratitis in Children - MEIBO-ROSACEE Recruiting NCT03479853
9 Subconjunctival Injection of Local Anesthetic in Anterior Blepharoptosis Repair Not yet recruiting NCT02959697 Not Applicable
10 Intralesional Tetracycline Injection in the Treatment of Chalazia Withdrawn NCT01763437 Early Phase 1 Tetracycline

Search NIH Clinical Center for Meibomian Cyst

Cochrane evidence based reviews: chalazion

Genetic Tests for Meibomian Cyst

Anatomical Context for Meibomian Cyst

MalaCards organs/tissues related to Meibomian Cyst:

41
Eye

Publications for Meibomian Cyst

Articles related to Meibomian Cyst:

# Title Authors Year
1
Transconjunctival elimination of keratin from an intratarsal meibomian cyst. ( 23250332 )
2013
2
Giant meibomian cyst--a case report. ( 2632453 )
1989
3
Changes in corneal topography and tear film stability due to a single Meibomian cyst. ( 3631209 )
1987
4
A CASE OF SECONDARY HAEMORRHAGE FOLLOWING CURETTAGE OF MEIBOMIAN CYST. ( 18169352 )
1936
5
EPITHELIOMA SIMULATING ULCERATED MEIBOMIAN CYST. ( 25259165 )
1894
6
Sarcoma of the Eyelid, Simulating a Meibomian Cyst. ( 16691807 )
1887

Variations for Meibomian Cyst

Expression for Meibomian Cyst

Search GEO for disease gene expression data for Meibomian Cyst.

Pathways for Meibomian Cyst

Pathways related to Meibomian Cyst according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.62 AR JUN
2 10.28 AR JUN

GO Terms for Meibomian Cyst

Biological processes related to Meibomian Cyst according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular process GO:0009987 8.62 AR JUN

Sources for Meibomian Cyst

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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