MCID: MBM001
MIFTS: 36

Meibomian Cyst

Categories: Endocrine diseases, Eye diseases, Skin diseases

Aliases & Classifications for Meibomian Cyst

MalaCards integrated aliases for Meibomian Cyst:

Name: Meibomian Cyst 12 15 17 70
Chalazion 12 73 44 32
Meibomian Gland Lipogranuloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9903
ICD9CM 34 373.2
MeSH 44 D017043
NCIt 50 C26717
SNOMED-CT 67 155172004
ICD10 32 H00.1
UMLS 70 C0007933

Summaries for Meibomian Cyst

Disease Ontology : 12 A blepharitis that is characterized as a cyst in the eyelid that is caused by inflammation of a blocked meibomian gland, usually on the upper eyelid.

MalaCards based summary : Meibomian Cyst, also known as chalazion, is related to internal hordeolum and eyelid carcinoma. An important gene associated with Meibomian Cyst is PLIN2 (Perilipin 2), and among its related pathways/superpathways is Keratinization. The drugs Tobramycin and Loteprednol have been mentioned in the context of this disorder. Affiliated tissues include eye, salivary gland and lymph node.

Wikipedia : 73 Chalazion (also known as Meibomian cyst) is a cyst in the eyelid due to a blocked oil gland. They are... more...

Related Diseases for Meibomian Cyst

Diseases related to Meibomian Cyst via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 234)
# Related Disease Score Top Affiliating Genes
1 internal hordeolum 31.6 MTRNR2L6 MTRNR2L5
2 eyelid carcinoma 30.3 KRT7 KRT20
3 sebaceous adenocarcinoma 30.2 PLIN2 PLIN1
4 eyelid benign neoplasm 30.2 PLIN2 KRT20
5 malignant syringoma 30.1 KRT7 KRT20
6 hordeolum 30.0 MTRNR2L6 MTRNR2L5
7 benign mesothelioma 29.9 KRT7 KRT20
8 muir-torre syndrome 29.8 PLIN2 KRT7
9 mature teratoma 29.7 SYP KRT7
10 cystic teratoma 29.6 SYP KRT7 KRT20
11 benign teratoma 29.6 SYP KRT7 KRT20
12 merkel cell carcinoma 29.6 SYP KRT7 KRT20
13 sweat gland cancer 29.4 SYP PLIN2 KRT7 KRT20
14 villous adenoma 10.3 KRT7 KRT20
15 urethral villous adenoma 10.3 KRT7 KRT20
16 bladder benign neoplasm 10.3 KRT7 KRT20
17 nephrogenic adenoma of urinary bladder 10.3 KRT7 KRT20
18 atrophic vulva 10.3 KRT7 KRT20
19 urinary bladder villous adenoma 10.3 KRT7 KRT20
20 vulva adenocarcinoma 10.3 KRT7 KRT20
21 female urethral cancer 10.3 KRT7 KRT20
22 cystitis cystica 10.3 KRT7 KRT20
23 mucinous ovarian cystadenoma 10.3 KRT7 KRT20
24 rectosigmoid junction neoplasm 10.3 KRT7 KRT20
25 transverse colon cancer 10.3 KRT7 KRT20
26 sigmoid neoplasm 10.3 KRT7 KRT20
27 vulvar apocrine adenocarcinoma 10.3 KRT7 KRT20
28 jejunal cancer 10.3 KRT7 KRT20
29 colonic lymphangioma 10.3 KRT7 KRT20
30 intratubular embryonal carcinoma 10.3 KRT7 KRT20
31 papillary transitional carcinoma 10.3 KRT7 KRT20
32 anal canal adenocarcinoma 10.3 KRT7 KRT20
33 supine hypotensive syndrome 10.3 KRT7 KRT20
34 mucinous bronchioloalveolar adenocarcinoma 10.3 KRT7 KRT20
35 jejunal adenocarcinoma 10.3 KRT7 KRT20
36 acute orbital inflammation 10.3 KRT7 KRT20
37 gastric diffuse adenocarcinoma 10.3 KRT7 KRT20
38 eccrine sweat gland cancer 10.3 KRT7 KRT20
39 glandular cystitis 10.3 KRT7 KRT20
40 nephrogenic adenoma of the urethra 10.3 KRT7 KRT20
41 pancreatic mucinous cystadenoma 10.3 KRT7 KRT20
42 linitis plastica 10.3 KRT7 KRT20
43 squamous papillomatosis 10.3 KRT7 KRT20
44 ovarian mucinous neoplasm 10.3 KRT7 KRT20
45 ovarian brenner tumor 10.3 KRT7 KRT20
46 thymus clear cell carcinoma 10.3 KRT7 KRT20
47 bladder clear cell adenocarcinoma 10.3 KRT7 KRT20
48 clear cell adenocarcinoma 10.3 KRT7 KRT20
49 clear cell basal cell carcinoma 10.3 KRT7 KRT20
50 breast osteosarcoma 10.3 KRT7 KRT20

Graphical network of the top 20 diseases related to Meibomian Cyst:



Diseases related to Meibomian Cyst

Symptoms & Phenotypes for Meibomian Cyst

Drugs & Therapeutics for Meibomian Cyst

Drugs for Meibomian Cyst (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tobramycin Approved, Investigational Phase 4 32986-56-4 5496 36294
2
Loteprednol Approved, Experimental Phase 4 82034-46-6, 129260-79-3 9865442 444025
3 Anti-Allergic Agents Phase 4
4
Fluorouracil Approved Phase 3 51-21-8 3385
5
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
6 Triamcinolone diacetate Phase 3
7 Hormone Antagonists Phase 3
8 Triamcinolone hexacetonide Phase 3
9 Immunosuppressive Agents Phase 3
10 Immunologic Factors Phase 3
11 Hormones Phase 3
12 triamcinolone acetonide Phase 3
13 glucocorticoids Phase 3
14 Antimetabolites Phase 3
15 Anti-Inflammatory Agents Phase 3
16
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
17
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
18 Gastrointestinal Agents
19 Antineoplastic Agents, Hormonal
20 Antiemetics
21
protease inhibitors
22 BB 1101
23 HIV Protease Inhibitors
24 Acidophilus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Safety and Efficacy Study of Zylet® (Loteprednol Etabonate 0.5% and Tobramycin 0.3% Ophthalmic Suspension) Compared to Vehicle in the Management of Lid Inflammation (Chalazion/Hordeolum) in Pediatric Subjects Completed NCT00420628 Phase 4 loteprednol etabonate/tobramycin opthalmic suspension;vehicle
2 A Multi-Center, Double-Masked, Randomized, Placebo-Controlled Evaluation of the Safety and Efficacy of SUN-131 Transdermal System (TDS) as Compared to Placebo TDS in Patients With a Chalazion (SUN-131-03) Completed NCT03248440 Phase 3 SUN-131 1.5% TDS;Placebo TDS
3 Pilot Study for Evaluation of LipiFlow Screening Methods Completed NCT01202747 Phase 2, Phase 3
4 Local 5-Fluorouracil Injection for the Treatment of Chalazia: A Prospective, Comparative Study Recruiting NCT02025023 Phase 3 5-fluorouracil Injection;Triamcinolone Acetonide;Triamcinolone Acetonide/5-fluorouracil mixture
5 A Multi-Center, Double-Masked, Randomized, Placebo-Controlled Evaluation of the Safety and Efficacy of SUN 131 Transdermal System (TDS) as Compared to Placebo TDS in Adult Patients With a Chalazion Completed NCT02338648 Phase 2 SUN-131 1.5% TDS;Placebo TDS
6 A 5-year Multicenter Prospective Randomized Trial Comparing Three Conservative Chalazion Treatments Completed NCT01230593 Hot Compress plus Tobramycin Drops and Ointment;Hot compress plus Tobramycin/Dexamethasone Drops and Ointment
7 Effects of Probiotic Oral Supplementation on the Treatment of Chalazion in Adults: a Pilot Study on 20 Patients Completed NCT04342507
8 Randomized Clinical Trial for Treatment of Meibomian Gland Dysfunction and Evaporative Dry Eye Completed NCT00832130
9 Intestinal Microbiota: a New Target for Chalaziosis Treatment in Children Completed NCT04322500
10 Intralesional Tetracycline Injection in the Treatment of Chalazia Withdrawn NCT01763437 Early Phase 1 Tetracycline

Search NIH Clinical Center for Meibomian Cyst

Cochrane evidence based reviews: chalazion

Genetic Tests for Meibomian Cyst

Anatomical Context for Meibomian Cyst

MalaCards organs/tissues related to Meibomian Cyst:

40
Eye, Salivary Gland, Lymph Node, Endothelial

Publications for Meibomian Cyst

Articles related to Meibomian Cyst:

(show top 50) (show all 462)
# Title Authors PMID Year
1
Increased incidence of chalazion associated with face mask wear during the COVID-19 pandemic. 61
33585724 2021
2
Ocular manifestations in renal allograft recipients: An Indian perspective. 61
33727456 2021
3
Ophthalmology residency trainers' perspective on standardization of residency training in India. 61
33727442 2021
4
[Inadvertent descemetorhexis as a complication of chalazion surgery]. 61
33431192 2021
5
Intestinal microbiome: a new target for chalaziosis treatment in children? 61
33226501 2021
6
Lower Eyelid Nodule: Chalazion or Idiopathic Facial Aseptic Granuloma? A Case Series. 61
33686444 2021
7
Prevalence and risk factors for chalazion in an older veteran population. 61
33789846 2021
8
Sebaceous carcinoma of the eyelid: 21-year experience in a Nordic country. 61
32749765 2021
9
Adenoid cystic carcinoma of the palpebral lobe of the lacrimal gland - case report and literature review. 61
33749533 2021
10
Oculofacial plastic surgery-related online search trends including the impact of the COVID-19 pandemic. 61
33317388 2021
11
Influence of Vitamin A deficiency on the transcriptomic profile of rat meibomian glands. 61
33481153 2021
12
Retrospective investigation of peripheric blood sampling in pediatric chalazion patients. 61
33389367 2021
13
Effects of Terpinen-4-ol on Meibomian Gland Epithelial Cells In Vitro. 61
32947397 2020
14
Nonosseous Periocular Manifestations of Langerhans Cell Histiocytosis: A Case Report and Systematic Review. 61
33315841 2020
15
Primary eyelid tuberculosis mimicking as chalazion in an immunocompetent child. 61
31847663 2020
16
A rare case of recurrent isolated eyelid myxoma: Case report and review of literature. 61
33322980 2020
17
Punctal dilatation and non-incisional canalicular curettage in the management of infectious canaliculitis. 61
31900017 2020
18
Curettage for Copious Conjunctival Concretions. 61
33403172 2020
19
Leukemia Cutis Resembling Chalazion. 61
31923093 2020
20
A Case of Giant Proliferative Periocular Pyogenic Granuloma. 61
33179542 2020
21
Serum Levels of Thyroid Hormone, Vitamin B12, Vitamin D3, Folic Acid, and Ferritin in Chalazion. 61
33054475 2020
22
Common inflammatory and infectious conditions of the eyelid. 61
32622681 2020
23
Molecular profiling of a primary cutaneous signet-ring cell/histiocytoid carcinoma of the eyelid. 61
32358805 2020
24
[Giant keratinized chalazion masquerading as a keratoacanthoma in a child]. 61
33004197 2020
25
Primary mucinous carcinoma of the skin arising from the upper eyelid: A case report and literature review. 61
32514425 2020
26
Eyelid margin Kaposi sarcoma leading to AIDS diagnosis. 61
33456161 2020
27
Primary Immunodeficiency Diseases Presenting with Chalazia as the First Manifestation. 61
32835554 2020
28
A Case Report on Bortezomib-Induced Bilateral Chalazion. 61
32999785 2020
29
Sebaceous Gland Carcinoma with Misleading Clinical Appearance: A Case Report of an Eyelid Lesion. 61
32788569 2020
30
Clinical features differentiating intratarsal keratinous cyst from chalazion. 61
32367161 2020
31
Eyelid nodules in idiopathic facial aseptic granuloma. 61
32868084 2020
32
Tarsal Epithelial Cysts: Prevalence, Case Series, and Synthesis of Existing Literature. 61
32826823 2020
33
Effects of chalazion and its treatments on the meibomian glands: a nonrandomized, prospective observation clinical study. 61
32652956 2020
34
An Unusual Presentation of a Dermoid Cyst Mimicking a Chalazion. 61
32579686 2020
35
Use of Chalazion clamp for stretch and stability of lip mucosa during micropigmentation. 61
32439459 2020
36
Bilateral and multifocal central serous chorioretinopathy after injecting triamcinolone into a chalazion. 61
32001028 2020
37
Deployed ophthalmic workload in support of US and NATO operations in Afghanistan. 61
32139414 2020
38
STAT1 gain-of-function and chronic demodicosis. 61
31637766 2020
39
Use of a chalazion clamp for intraoral biopsies: a technical note. 61
31718917 2020
40
Demography and Clinical Features of Chalazion Among Patients Seen at a Multi-Tier Eye Care Network in India: An Electronic Medical Records Driven Big Data Analysis Report. 61
32801626 2020
41
Rapid healing of a persistent corneal epithelial defect (PCED) with autologous serum treatment. 61
31929219 2020
42
Evaluation of diagnosed cases of eye rhinosporidiosis in a public hospital of Maranhão, Northeast Brazil. 61
31703563 2019
43
Neurothekeoma of the eye, conjunctiva, and periorbital adnexa: A report of two cases and brief review. 61
30978337 2019
44
[Periocular metastasis as differential diagnosis of pyogenic granuloma and therapeutic marker of a systemic disease]. 61
30874885 2019
45
Epibulbar complex choristoma with simultaneous involvement of eyelid: a case report. 61
31718612 2019
46
Eyelid chalazion or not? 61
31546469 2019
47
Delayed treatment of endocrine mucin-producing sweat gland carcinoma initially diagnosed as a chalazion. 61
31516999 2019
48
Primary hepatic carcinoid tumor metastasizing to eyelid: A case report. 61
31341995 2019
49
Erratum: A rare masquerade of chalazion: Adenoid cystic carcinoma. 61
31436223 2019
50
A prospective randomized study comparing incision and curettage with injection of triamcinolone acetonide for chronic chalazia. 61
31528769 2019

Variations for Meibomian Cyst

Expression for Meibomian Cyst

Search GEO for disease gene expression data for Meibomian Cyst.

Pathways for Meibomian Cyst

Pathways related to Meibomian Cyst according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.25 SPRR2D KRT7 KRT20

GO Terms for Meibomian Cyst

Cellular components related to Meibomian Cyst according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid droplet GO:0005811 8.8 PLIN3 PLIN2 PLIN1

Biological processes related to Meibomian Cyst according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.5 SPRR2D KRT7 KRT20
2 negative regulation of signaling receptor activity GO:2000272 9.37 MTRNR2L6 MTRNR2L5
3 lipid storage GO:0019915 9.26 PLIN3 PLIN2
4 negative regulation of execution phase of apoptosis GO:1900118 9.16 MTRNR2L6 MTRNR2L5
5 cornification GO:0070268 9.13 SPRR2D KRT7 KRT20
6 positive regulation of sequestering of triglyceride GO:0010890 8.62 PLIN3 PLIN2

Molecular functions related to Meibomian Cyst according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor antagonist activity GO:0048019 8.62 MTRNR2L6 MTRNR2L5

Sources for Meibomian Cyst

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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