MCID: MBM001
MIFTS: 34

Meibomian Cyst

Categories: Endocrine diseases, Eye diseases

Aliases & Classifications for Meibomian Cyst

MalaCards integrated aliases for Meibomian Cyst:

Name: Meibomian Cyst 12 15 73
Chalazion 12 76 44
Meibomian Gland Lipogranuloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9903
ICD10 33 H00.1
ICD9CM 35 373.2
MeSH 44 D017043
NCIt 50 C26717
SNOMED-CT 68 1482004
UMLS 73 C0007933

Summaries for Meibomian Cyst

Disease Ontology : 12 A blepharitis that is characterized as a cyst in the eyelid that is caused by inflammation of a blocked meibomian gland, usually on the upper eyelid.

MalaCards based summary : Meibomian Cyst, also known as chalazion, is related to sebaceous adenocarcinoma and malignant syringoma. An important gene associated with Meibomian Cyst is PIN1 (Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1), and among its related pathways/superpathways are FOXA1 transcription factor network and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs Tobramycin and Loteprednol have been mentioned in the context of this disorder. Affiliated tissues include eye, lung and kidney.

Wikipedia : 76 Chalazion is a cyst in the eyelid due to a blocked oil gland. They are typically in the middle of the... more...

Related Diseases for Meibomian Cyst

Diseases related to Meibomian Cyst via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 155)
# Related Disease Score Top Affiliating Genes
1 sebaceous adenocarcinoma 30.1 AR PLIN2
2 malignant syringoma 30.1 KRT20 KRT7
3 eyelid carcinoma 30.1 KRT20 KRT7
4 internal hordeolum 11.1
5 cystadenoma 10.2 KRT20 KRT7
6 cystic basal cell carcinoma 10.2 KRT20 KRT7
7 seminal vesicle adenocarcinoma 10.2 KRT20 KRT7
8 transverse colon cancer 10.2 KRT20 KRT7
9 appendix adenocarcinoma 10.2 KRT20 KRT7
10 glandular cystitis 10.2 KRT20 KRT7
11 papillary transitional carcinoma 10.2 KRT20 KRT7
12 krukenberg carcinoma 10.2 KRT20 KRT7
13 large intestine adenocarcinoma 10.2 KRT20 KRT7
14 linitis plastica 10.2 KRT20 KRT7
15 lung acinar adenocarcinoma 10.2 KRT20 KRT7
16 small cell carcinoma of the bladder 10.2 KRT20 KRT7
17 adenoid squamous cell carcinoma 10.2 KRT20 KRT7
18 intratubular embryonal carcinoma 10.2 KRT20 KRT7
19 bile duct adenoma 10.2 KRT20 KRT7
20 jejunal adenocarcinoma 10.2 KRT20 KRT7
21 ovarian mucinous adenocarcinoma 10.2 KRT20 KRT7
22 mucinous adenocarcinoma 10.2 KRT20 KRT7
23 appendix disease 10.2 KRT20 KRT7
24 gastric diffuse adenocarcinoma 10.2 KRT20 KRT7
25 bladder lymphoma 10.2 KRT20 KRT7
26 papillary serous adenocarcinoma 10.2 KRT20 KRT7
27 bladder adenocarcinoma 10.2 KRT20 KRT7
28 chronic cystitis 10.2 KRT20 KRT7
29 medulloepithelioma 10.2 KRT20 KRT7
30 glycogen-rich clear cell breast carcinoma 10.2 KRT20 KRT7
31 renal pelvis carcinoma 10.2 KRT20 KRT7
32 mucinous bronchioloalveolar adenocarcinoma 10.2 KRT20 KRT7
33 ampulla of vater adenocarcinoma 10.2 KRT20 KRT7
34 lymphoepithelioma-like carcinoma 10.2 KRT20 KRT7
35 endocervical adenocarcinoma 10.2 KRT20 KRT7
36 eccrine sweat gland neoplasm 10.2 KRT20 KRT7
37 dermoid cyst 10.2 KRT20 KRT7
38 cystadenofibroma 10.2 KRT20 KRT7
39 thymus lipoma 10.2 KRT20 KRT7
40 mucinous cystadenocarcinoma 10.2 KRT20 KRT7
41 morpheaform basal cell carcinoma 10.2 AR KRT20
42 appendix cancer 10.2 KRT20 KRT7
43 prostatic acinar adenocarcinoma 10.2 KRT20 KRT7
44 immune system organ benign neoplasm 10.2 KRT20 KRT7
45 neurofibroma 10.2
46 cystic teratoma 10.2 KRT20 KRT7
47 ovarian cystic teratoma 10.2 KRT20 KRT7
48 horseshoe kidney 10.2 KRT20 KRT7
49 adenocarcinoma in situ 10.2 KRT20 KRT7
50 large cell neuroendocrine carcinoma 10.2 KRT20 KRT7

Graphical network of the top 20 diseases related to Meibomian Cyst:



Diseases related to Meibomian Cyst

Symptoms & Phenotypes for Meibomian Cyst

Drugs & Therapeutics for Meibomian Cyst

Drugs for Meibomian Cyst (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tobramycin Approved, Investigational Phase 4,Not Applicable 32986-56-4 36294 5496
2
Loteprednol Approved, Experimental Phase 4 82034-46-6, 129260-79-3 9865442 444025
3 Anti-Bacterial Agents Phase 4,Not Applicable,Early Phase 1
4 Anti-Allergic Agents Phase 4
5 Anti-Infective Agents Phase 4,Not Applicable,Early Phase 1
6
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
7
Fluorouracil Approved Phase 3 51-21-8 3385
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Not Applicable
9 Hormone Antagonists Phase 3,Not Applicable
10 Hormones Phase 3,Not Applicable
11 Anti-Inflammatory Agents Phase 3,Not Applicable
12 glucocorticoids Phase 3,Not Applicable
13 triamcinolone acetonide Phase 3
14 Antimetabolites, Antineoplastic Phase 3
15 Immunologic Factors Phase 3
16 Triamcinolone diacetate Phase 3
17 Immunosuppressive Agents Phase 3
18 Triamcinolone hexacetonide Phase 3
19 Antimetabolites Phase 3
20
Dexamethasone Approved, Investigational, Vet_approved Not Applicable 50-02-2 5743
21
Dexamethasone acetate Approved, Investigational, Vet_approved Not Applicable 1177-87-3
22 BB 1101 Not Applicable
23 Peripheral Nervous System Agents Not Applicable
24 Gastrointestinal Agents Not Applicable
25 HIV Protease Inhibitors Not Applicable
26
protease inhibitors Not Applicable
27 Antiemetics Not Applicable
28 Autonomic Agents Not Applicable
29 Antineoplastic Agents, Hormonal Not Applicable
30 Central Nervous System Depressants Not Applicable
31 Anesthetics Not Applicable
32 Anesthetics, Local Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pediatric Zylet Safety and Efficacy Study Completed NCT00420628 Phase 4 loteprednol etabonate/tobramycin opthalmic suspension;vehicle
2 Safety and Efficacy Study of SUN-131 Transdermal System (TDS) as Compared to Placebo TDS in Patients With a Chalazion Completed NCT03248440 Phase 3 SUN-131 1.5% TDS;Placebo TDS
3 Evaluation of Screening Methods for Treatment of Meibomian Gland Dysfunction Completed NCT01202747 Phase 2, Phase 3
4 Chalazia Treatment Study Recruiting NCT02025023 Phase 3 5-fluorouracil Injection;Triamcinolone Acetonide;Triamcinolone Acetonide/5-fluorouracil mixture
5 Safety and Efficacy Study of SUN 131 TDS as Compared to Placebo TDS in Adult Patients With a Chalazion Completed NCT02338648 Phase 2 SUN-131 1.5% TDS;Placebo TDS
6 Chalazion Conservative Treatment Trial Completed NCT01230593 Not Applicable Hot Compress plus Tobramycin Drops and Ointment;Hot compress plus Tobramycin/Dexamethasone Drops and Ointment
7 Treatment of Meibomian Gland Dysfunction and Evaporative Dry Eye Completed NCT00832130 Not Applicable
8 Subconjunctival Injection of Local Anesthetic in Anterior Blepharoptosis Repair Recruiting NCT02959697 Not Applicable Subcut. + Subconj. Xylocaine;Subcut. + Sham Subconj. Injection
9 Clinical, Meibographic and Interferometric Evaluation of Phlyctenular Keratitis in Children - MEIBO-ROSACEE Recruiting NCT03479853
10 Intralesional Tetracycline Injection in the Treatment of Chalazia Withdrawn NCT01763437 Early Phase 1 Tetracycline

Search NIH Clinical Center for Meibomian Cyst

Cochrane evidence based reviews: chalazion

Genetic Tests for Meibomian Cyst

Anatomical Context for Meibomian Cyst

MalaCards organs/tissues related to Meibomian Cyst:

41
Eye, Lung, Kidney, Colon, Ovary, Prostate, Thymus

Publications for Meibomian Cyst

Articles related to Meibomian Cyst:

(show top 50) (show all 143)
# Title Authors Year
1
Development of Central Serous Chorioretinopathy following Chalazion Removal with Intralesional Triamcinolone Injection: A Case Report. ( 30323759 )
2018
2
Isolated neurofibroma of the eyelid mimicking recurrent chalazion. ( 29480265 )
2018
3
Pilomatrixoma Masquerading as Giant Chalazion. ( 30454715 )
2018
4
Sebaceous carcinoma mimicking a chalazion in a young patient. ( 29287845 )
2018
5
The effects of chalazion surgery on intraocular pressure and corneal topography. ( 29594788 )
2018
6
A case of localized amyloidosis of the eyelid misdiagnosed as recurrent chalazion. ( 28860919 )
2017
7
Recurrent profuse hemorrhage after chalazion excision in a patient with systemic amyloidosis. ( 28774538 )
2017
8
External chalazion as reddish and intractable lower eyelid nodules in a child. ( 27790750 )
2017
9
Extratarsal presentation of chalazion. ( 27942990 )
2017
10
Using a chalazion clamp to enhance dermoscopy of oral mucosal lesions. ( 28212774 )
2017
11
Unilateral primary tuberculosis presenting as an extratarsal chalazion. ( 28237159 )
2017
12
Reply re: "The Combined Chalazion Excision-Steroid Injection Procedure". ( 28272170 )
2017
13
Eyelid Fat Atrophy and Depigmentation After an Intralesional Injection of Triamcinolone Acetonide to Treat Chalazion. ( 28468185 )
2017
14
Changes in meibomian gland morphology and ocular higher-order aberrations in eyes with chalazion. ( 28615923 )
2017
15
Serum Vitamin A Levels in Patients with Chalazion. ( 29392144 )
2017
16
Atypical Presentation of a Complex Eyelid Choristoma Mimicking a Chalazion with Pyogenic Granuloma. ( 27210602 )
2016
17
When Is a Chalazion Not a Chalazion? ( 27428621 )
2016
18
A treatment method for chronic suppurative lacrimal canaliculitis using chalazion forceps. ( 27688281 )
2016
19
Reinventing the Chalazion clamp: Modification of the instrument for the procedural dermatologist. ( 27745650 )
2016
20
Hypertrophic scar of the conjunctiva presenting as an eyelid mass: an unusual complication after surgical treatment of a chalazion. ( 27752457 )
2016
21
Massive Recurrent Chalazion With Anterior Orbital Extension. ( 27828923 )
2016
22
The use of chalazion clamps to create adequate sustained pressure for slit skin smear. ( 26702808 )
2016
23
An asystolic event after eyelid skin bupivicaine injection during chalazion surgery. ( 26917079 )
2016
24
Orbital phlegmona from upper eyelid chalazion. ( 27215967 )
2016
25
Granular cell tumor masquerading as a chalazion: a case report. ( 24481512 )
2015
26
IgG4-related disease mimicking chalazion in the upper eyelid with skin manifestations on the trunk. ( 25834990 )
2015
27
Cutaneous squamous cell carcinoma of the eyelid masquerading as a chalazion. ( 25479697 )
2015
28
Chalazion clamp in dermatology revisited. ( 25851765 )
2015
29
Demodex mites as potential etiological factor in chalazion - a study in Poland. ( 26408604 )
2015
30
Differentiation between chalazion and sebaceous carcinoma by noninvasive meibography. ( 25258508 )
2014
31
Lacrimal gland duct stones: misdiagnosed as chalazion in 3 cases. ( 24513366 )
2014
32
Eyelid nodule in a child: a chalazion or idiopathic facial aseptic granuloma? ( 24858529 )
2014
33
The effects of chalazion excision on corneal surface aberrations. ( 24890201 )
2014
34
Sebaceoma of the conjunctiva presenting as a chalazion. ( 25284872 )
2014
35
A comparison of intralesional triamcinolone acetonide injection for primary chalazion in children and adults. ( 25386597 )
2014
36
Intratarsal keratinous cyst mimicking a large chalazion. ( 25433752 )
2014
37
Transconjunctival elimination of keratin from an intratarsal meibomian cyst. ( 23250332 )
2013
38
Unusual case of orbital apex syndrome after chalazion excision. ( 22957835 )
2013
39
Effects of chalazion excision on ocular aberrations. ( 23086368 )
2013
40
Suspected spinocellular carcinoma of the inferior eyelid resulted multiple chalazion. ( 23343591 )
2013
41
Retained soft contact lens masquerading as a chalazion: a case report. ( 23412528 )
2013
42
Tuberculosis of eyelid presenting as a chalazion. ( 23642745 )
2013
43
A para-canalicular abscess resembling an inflamed chalazion. ( 23762696 )
2013
44
It is not chalazion. ( 23772132 )
2013
45
Chalazion management--surgical treatment versus triamcinolon application. ( 23837252 )
2013
46
Trichilemmal cyst of the eyelid: masquerading as recurrent chalazion. ( 22606489 )
2012
47
Budesonide-induced periorificial dermatitis presenting as chalazion and blepharitis. ( 21895758 )
2011
48
Dermabond as a hemostatic agent in chalazion excision in a hemophiliac. ( 20966799 )
2011
49
Case report: Chalazion and its features visualized by ultrahigh resolution optical coherence tomography. ( 21094077 )
2011
50
Spontaneous resolution of chalazion after 3 to 5 years. ( 20531204 )
2010

Variations for Meibomian Cyst

Expression for Meibomian Cyst

Search GEO for disease gene expression data for Meibomian Cyst.

Pathways for Meibomian Cyst

Pathways related to Meibomian Cyst according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.62 AR JUN
2 10.28 AR JUN

GO Terms for Meibomian Cyst

Biological processes related to Meibomian Cyst according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell differentiation GO:0045597 8.96 AR JUN
2 cellular process GO:0009987 8.62 AR JUN

Sources for Meibomian Cyst

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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