Aliases & Classifications for Melancholia

MalaCards integrated aliases for Melancholia:

Name: Melancholia 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2848
MeSH 44 D003866
NCIt 50 C34812
SNOMED-CT 68 35489007
UMLS 73 C0025193

Summaries for Melancholia

MalaCards based summary : Melancholia is related to endogenous depression and major depressive disorder. An important gene associated with Melancholia is CRH (Corticotropin Releasing Hormone), and among its related pathways/superpathways are amb2 Integrin signaling and Overview of nanoparticle effects. The drugs Nortriptyline and Sertraline have been mentioned in the context of this disorder. Affiliated tissues include testes, pituitary and brain.

Wikipedia : 76 Melancholia (from Greek: µέλαινα χολή, melaina chole), also lugubriousness, from the Latin lugere, to... more...

Related Diseases for Melancholia

Diseases related to Melancholia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 endogenous depression 32.7 CRH IER3IP1
2 major depressive disorder 30.0 CRH PRL TNF
3 depression 10.7
4 hypothalamic disease 10.7 CRH PRL
5 pituitary carcinoma 10.6 CRH PRL
6 nelson syndrome 10.6 CRH PRL
7 sheehan syndrome 10.6 CRH PRL
8 acth-secreting pituitary adenoma 10.6 CRH PRL
9 adrenal cortex disease 10.6 CRH PRL
10 adrenal gland disease 10.6 CRH PRL
11 pituitary-dependent cushing's disease 10.6 CRH PRL
12 endocrine organ benign neoplasm 10.6 CRH PRL
13 adrenal gland hyperfunction 10.6 CRH PRL
14 pituitary gland disease 10.5 CRH PRL
15 diabetes insipidus 10.5 CRH PRL
16 amenorrhea 10.5 CRH PRL
17 mental depression 10.4 CRH IER3IP1
18 hypopituitarism 10.4 CRH PRL
19 congenital disorder of glycosylation, type ia 10.4 HP TF
20 epileptic encephalopathy, early infantile, 36 10.4 HP TF
21 burns 10.4 CRH TNF
22 substance abuse 10.4 PRL TF
23 atransferrinemia 10.4 HP TF
24 testicular yolk sac tumor 10.3 HP TF
25 fructose intolerance, hereditary 10.3 HP TF
26 hemoglobinopathy 10.3 HP TF
27 sleeping sickness 10.3 HP TF
28 haemophilus influenzae 10.3 TF TNF
29 radiation proctitis 10.3 TF TNF
30 alcohol abuse 10.3 PRL TF
31 eales disease 10.3 TF TNF
32 congenital hemolytic anemia 10.3 HP TF
33 protein-energy malnutrition 10.2 TF TNF
34 irritable bowel syndrome 10.2 CRH TNF
35 female reproductive system disease 10.2 PRL TNF
36 irritant dermatitis 10.2 IER3IP1 TNF
37 chronic pulmonary heart disease 10.2 HP TNF
38 endometritis 10.2 HP TNF
39 rosacea 10.2 IER3IP1 TNF
40 adult respiratory distress syndrome 10.2 TF TNF
41 rheumatic fever 10.2 HP TNF
42 aging 10.1
43 mood disorder 10.1
44 chronic fatigue syndrome 10.1 CRH TNF
45 guillain-barre syndrome 10.1 HP TNF
46 reproductive system disease 10.1 PRL TNF
47 intermittent explosive disorder 10.1 CRP PRL
48 parasitic protozoa infectious disease 10.1 HP TNF
49 folic acid deficiency anemia 10.1 CRP TF
50 sleep disorder 10.0 CRP PRL

Graphical network of the top 20 diseases related to Melancholia:



Diseases related to Melancholia

Symptoms & Phenotypes for Melancholia

Drugs & Therapeutics for Melancholia

Drugs for Melancholia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nortriptyline Approved Phase 4 72-69-5 4543
2
Sertraline Approved Phase 4 79617-96-2 68617
3
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
4
Citalopram Approved Phase 4,Phase 3,Not Applicable 59729-33-8 2771
5
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
6
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
7
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
8
Lamotrigine Approved, Investigational Phase 4,Phase 3 84057-84-1 3878
9 Adrenergic Agents Phase 4
10 Antidepressive Agents Phase 4,Phase 3,Phase 2,Not Applicable
11 Antidepressive Agents, Tricyclic Phase 4
12 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
13 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
14 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Not Applicable
15 Serotonin Agents Phase 4,Phase 3,Phase 2,Not Applicable
16 Serotonin Uptake Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
17 Antipsychotic Agents Phase 4,Phase 3
18 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
19 Quetiapine Fumarate Phase 4 111974-72-2
20 Tranquilizing Agents Phase 4,Phase 3,Phase 2
21 Desvenlafaxine Succinate Phase 4 386750-22-7
22 Duloxetine Hydrochloride Phase 4,Phase 3
23 Venlafaxine Hydrochloride Phase 4
24 Vilazodone Hydrochloride Phase 4 163521-08-2
25 Anticonvulsants Phase 4,Phase 3
26 calcium channel blockers Phase 4,Phase 3
27 Calcium, Dietary Phase 4,Phase 3
28 Diuretics, Potassium Sparing Phase 4,Phase 3
29 Excitatory Amino Acid Antagonists Phase 4,Phase 3
30 Excitatory Amino Acids Phase 4,Phase 3
31 Sodium Channel Blockers Phase 4,Phase 3
32
Serotonin Investigational, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 50-67-9 5202
33
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
34
Norepinephrine Approved Phase 3 51-41-2 439260
35
Vortioxetine Approved, Investigational Phase 3,Phase 2 508233-74-7 9966051
36
Risperidone Approved, Investigational Phase 3 106266-06-2 5073
37
Ziprasidone Approved Phase 3 146939-27-7 60854
38 Analgesics Phase 3
39 Dopamine Agents Phase 3
40 Peripheral Nervous System Agents Phase 3,Not Applicable
41 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
42 Anti-Anxiety Agents Phase 3,Phase 2
43 Serotonin 5-HT1 Receptor Agonists Phase 3,Phase 2
44 Serotonin 5-HT3 Receptor Antagonists Phase 3,Phase 2
45 Serotonin Antagonists Phase 3,Phase 2
46 Dopamine Antagonists Phase 3
47 Antidepressive Agents, Second-Generation Phase 3,Not Applicable
48 Antiparkinson Agents Phase 3,Not Applicable
49 Autonomic Agents Phase 3,Not Applicable
50 Cholinergic Agents Phase 3,Not Applicable

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 Antidepressant Treatment of Melancholia in Late Life Completed NCT00000378 Phase 4 Sertraline;Nortriptyline
2 Quetiapine in Melancholic Depression Completed NCT01200901 Phase 4 Quetiapine
3 Effects of Treatment on Decision-making in Major Depression Completed NCT01916824 Phase 4 Any FDA Approved Antidepressant
4 Melancholic Depression and Insomnia as Predictors of Response to Quetiapine in Patients With Major Depression Active, not recruiting NCT03207438 Phase 4 Quetiapine 50 MG Extended Release Oral Tablet;Quetiapine Fumarate XR 150-300 mg;Placebos
5 Melancholic Symptoms in Bipolar Depression and Responsiveness to Lamotrigine Active, not recruiting NCT02989727 Phase 4 Lamotrigine;Placebos
6 Duloxetine in the Treatment of Melancholic Depression Completed NCT00191685 Phase 3 duloxetine
7 Depression And Bipolar Disorder Completed NCT00274677 Phase 3 Placebo;lamotrigine
8 Bipolar Disorder Study for Men and Women Completed NCT00056277 Phase 3 lamotrigine
9 Study Evaluating DVS-233 SR In Adult Outpatients With Major Depressive Disorder Completed NCT00072774 Phase 3 DVS-233 SR
10 Safety and Tolerability of Vortioxetine (LuAA21004) - Open Label Extension Study Completed NCT01152996 Phase 3 Vortioxetine
11 Efficacy and Safety Study of Vortioxetine (Lu AA21004) for Treatment of Major Depressive Disorder Completed NCT01255787 Phase 2, Phase 3 Vortioxetine;Placebo
12 Efficacy and Safety Study of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder Completed NCT01163266 Phase 3 Vortioxetine;Placebo
13 Safety and Efficacy of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder Completed NCT01153009 Phase 3 Vortioxetine;Duloxetine;Placebo
14 A Study of the Effectiveness and Safety of Risperidone to Augment SSRI Therapy in Patients With Treatment-resistant Depression Completed NCT00044681 Phase 3 risperidone
15 Safety and Tolerability of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder Completed NCT00707980 Phase 3 Vortioxetine
16 A Six-Week Flexible Dose Study Evaluating the Efficacy and Safety of Geodon in Patients With Bipolar I Depression. Completed NCT00282464 Phase 3 Placebo;Geodon (Ziprasidone)
17 A Six-Week Study Evaluating The Efficacy And Safety Of Geodon In Patients With A Diagnosis Of Bipolar I Depression Completed NCT00141271 Phase 3 Geodon (Ziprasidone);Geodon (Ziprasidone);Placebo
18 Efficacy Study of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder Completed NCT00735709 Phase 3 Vortioxetine;Placebo
19 Escitalopram, Placebo and tDCS in Depression: a Non-inferiority Trial Completed NCT01894815 Phase 3 Escitalopram oxalate
20 Serotonin Transporter Density in Late-life Depression With and Without Dementia Completed NCT01548937 Phase 2 I-123 ADAM
21 A Study of the Effects of a New Antidepressant Treatment (GSK561679) in Females With Major Depressive Disorder Completed NCT00733980 Phase 2 GSK561679
22 Safety and Efficacy Study in Patients With Major Depressive Disorder Completed NCT00896363 Phase 2 GSK163090 1 mg;GSK163090 Placebo;GSK163090 3 mg
23 Orvepitant (GW823296) in Adult Post Traumatic Stress Disorder Completed NCT01000493 Phase 2 orvepitant
24 A Study Of The Efficacy And Safety Of CP-601,927 Augmentation Of Antidepressant Therapy In Major Depression Terminated NCT01098240 Phase 2 CP-601,927
25 A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Fixed Dose Study Evaluating the Efficacy and Safety of Orvepitant in Subjects With Major Depressive Disorder Terminated NCT00880399 Phase 2 orvepitant
26 A Randomised, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Orvepitant in Subjects With Major Depressive Disorder Terminated NCT00880048 Phase 2 orvepitant
27 Effects of 3 Months of Selective Serotonin Reuptake Inhibitor (SSRI)-Treatment on Metabolism and Hypothalamic-pituitary-adrenal (HPA)-Axis in Young Men Born With Low Birth Weight Completed NCT00971815 Not Applicable Escitalopram;placebo
28 Study of the Hypothalmic-Pituitary-Adrenal (HPA) Axis and Its Role in Major Depression Completed NCT00001479
29 Stepped Care aiTBS 2 Depression Study (Ghent) Recruiting NCT03288675 Not Applicable SSRI
30 Movement for Depression - An RCT Assessing the Effects of Physical Activity Promotion for People With MDD Recruiting NCT03403881 Not Applicable
31 Study of Quality of Life in Freeman-Sheldon Syndrome and Related Conditions Terminated NCT01307475

Search NIH Clinical Center for Melancholia

Genetic Tests for Melancholia

Anatomical Context for Melancholia

MalaCards organs/tissues related to Melancholia:

41
Testes, Pituitary, Brain, Eye, Prefrontal Cortex, Thyroid, Cortex

Publications for Melancholia

Articles related to Melancholia:

(show top 50) (show all 373)
# Title Authors Year
1
Aspects of Additional Psychiatric Disorders in Severe Depression/Melancholia: A Comparison between Suicides and Controls and General Pattern. ( 29933593 )
2018
2
Putamen Volume Differences Among Older Adults: Depression Status, Melancholia, and Age. ( 29251178 )
2018
3
Lipid Peroxidation and Immune Biomarkers Are Associated with Major Depression and Its Phenotypes, Including Treatment-Resistant Depression and Melancholia. ( 29103192 )
2018
4
Cortisol trajectory, melancholia, and response to electroconvulsive therapy. ( 29775916 )
2018
5
Melancholia and cancer: The bladder cancer narrative. ( 29660788 )
2018
6
Social death, melancholia, and zombies: Same patterns? ( 28351493 )
2017
7
Debate on "Defining melancholia: A core mood disorder". ( 28987022 )
2017
8
The genealogy of major depression: symptoms and signs of melancholia from 1880 to 1900. ( 28785109 )
2017
9
Are there differences in lipid peroxidation and immune biomarkers between major depression and bipolar disorder: Effects of melancholia, atypical depression, severity of illness, episode number, suicidal ideation and prior suicide attempts. ( 28867391 )
2017
10
Defining melancholia: A core mood disorder. ( 28599349 )
2017
11
The properties and utility of the CORE measure of melancholia. ( 27721186 )
2017
12
The Devolution of Melancholia Into Psychosis: The Case of a Child Whose Mother Was Unable to Grieve. ( 29022850 )
2017
13
To define melancholia, follow the path of catatonia. ( 28691306 )
2017
14
Retrospective: Pursuing melancholia - The Australian contribution. ( 28030975 )
2017
15
Love and melancholia in the analysis of women by women. ( 28671276 )
2017
16
Melancholia, Narcissism and Depression. ( 27377400 )
2016
17
Melancholia, Narcissism and Depression. ( 28638134 )
2016
18
Postpartum Psychosis: Madness, Mania, and Melancholia in Motherhood. ( 27609245 )
2016
19
Anticipatory Reward Deficits in Melancholia. ( 27175986 )
2016
20
Associations of Serum Cytokine Receptor Levels with Melancholia, Staging of Illness, Depressive and Manic Phases, and Severity of Depression in Bipolar Disorder. ( 27660275 )
2016
21
The History of Melancholia Disease. ( 27516703 )
2016
22
The History of Melancholia Disease. ( 27840541 )
2016
23
THE SORROWS OF YOUNG WERTHER AND GOETHE'S UNDERSTANDING OF MELANCHOLIA. ( 26784722 )
2016
24
Relationship between prefrontal hemodynamic responses and quality of life differs between melancholia and non-melancholic depression. ( 27259838 )
2016
25
Melancholia. ( 26499302 )
2015
26
Disrupted effective connectivity of cortical systems supporting attention and interoception in melancholia. ( 25692565 )
2015
27
Melancholia before the twentieth century: fear and sorrow or partial insanity? ( 25691879 )
2015
28
Scene unseen: Disrupted neuronal adaptation in melancholia during emotional film viewing. ( 26740919 )
2015
29
ON LOVE AND MELANCHOLIA IN MARGUERITE DURAS'S AUTOFICTION. ( 26198607 )
2015
30
Agoraphobia and Melancholia: Thoughts on Milrod's "Emptiness in Agoraphobia Patients". ( 26263925 )
2015
31
Melancholia Associated With Severe Cognitive Disorders as the Expression of Late-Onset Postpartum Anti-N-Methyl-d-Aspartic Acid Receptor Limbic Encephalitis. ( 25923872 )
2015
32
Inaccessible Masturbation, Impossible Mourning: Collective Melancholia, the Prohibition on Female Sexual Subjects in India, and Masturbation Fantasy as a Zone of the Strange. ( 26653059 )
2015
33
Melancholia and catatonia: disorders or specifiers? ( 25417594 )
2015
34
Sifting through the sands of time: mourning and melancholia revisited via the documentary Nostalgia for the Light (2011). ( 24628289 )
2014
35
Melancholia in medieval Persian literature: The view of Hidayat of Al-Akhawayni. ( 25019055 )
2014
36
Brief, unidimensional melancholia rating scales are highly sensitive to the effect of citalopram and may have biological validity: implications for the research domain criteria (RDoC). ( 24836083 )
2014
37
Major depressive disorder with melancholia displays robust alterations in resting state heart rate and its variability: implications for future morbidity and mortality. ( 25505893 )
2014
38
Microbiota, the immune system, black moods and the brain-melancholia updated. ( 25309394 )
2014
39
Psychometric analysis of the Melancholia Scale in trials with non-pharmacological augmentation of patients with therapy-resistant depression. ( 25142191 )
2014
40
Association between core-assigned melancholia and the melancholia subscale of the HAM-D. ( 25451414 )
2014
41
Fewer study participants needed to demonstrate superior antidepressant efficacy when using the Hamilton melancholia subscale (HAM-D6) as outcome measure. ( 25487682 )
2014
42
Right temporal activation differs between melancholia and nonmelancholic depression: a multichannel near-infrared spectroscopy study. ( 24780385 )
2014
43
Antidepressant treatment of melancholia in older adults. ( 24119858 )
2014
44
Melancholia: definition and management. ( 24270479 )
2014
45
The impact of melancholia versus non-melancholia on resting-state, EEG alpha asymmetry: electrophysiological evidence for depression heterogeneity. ( 24467874 )
2014
46
Melancholia in later life: late and early onset differences in presentation, course, and dementia risk. ( 24677247 )
2014
47
Melancholia: past and present. ( 23547641 )
2013
48
Treating melancholia at home: theoretical wisdom and grim reality in the career of E.C. Seguin. ( 23628930 )
2013
49
Melancholia: a distinct entity? ( 23547639 )
2013
50
Malaise, melancholia and madness: the evolutionary legacy of an inflammatory bias. ( 23639523 )
2013

Variations for Melancholia

Expression for Melancholia

Search GEO for disease gene expression data for Melancholia.

Pathways for Melancholia

Pathways related to Melancholia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.84 HP TNF
2 10.23 CRP TNF
3 9.58 PRL TNF

GO Terms for Melancholia

Cellular components related to Melancholia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CRH CRP HP PRL TF TNF
2 extracellular space GO:0005615 9.1 CRH CRP HP PRL TF TNF

Biological processes related to Melancholia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.54 CRH CRP TNF
2 positive regulation of gene expression GO:0010628 9.5 CRH CRP TNF
3 positive regulation of cell death GO:0010942 9.26 CRH HP
4 negative regulation of endothelial cell proliferation GO:0001937 9.16 PRL TNF
5 acute-phase response GO:0006953 8.96 CRP HP
6 negative regulation of lipid storage GO:0010888 8.62 CRP TNF

Sources for Melancholia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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