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MCID: MLN003
MIFTS: 38

Melancholia

Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Melancholia

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MalaCards integrated aliases for Melancholia:

Name: Melancholia 12 15 17 71

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2848
MeSH 43 D003866
NCIt 49 C34812
UMLS 71 C0025193
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Summaries for Melancholia

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MalaCards based summary : Melancholia is related to endogenous depression and depression. An important gene associated with Melancholia is CRH (Corticotropin Releasing Hormone), and among its related pathways/superpathways are Serotonergic synapse and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Sertraline and Nortriptyline have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and pituitary, and related phenotype is endocrine/exocrine gland.

Wikipedia : 74 Melancholia (from Greek: µέλαινα χολή melaina chole "black bile", "blackness of the bile" also Latin... more...

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Related Diseases for Melancholia

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Diseases related to Melancholia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 227)
# Related Disease Score Top Affiliating Genes
1 endogenous depression 30.7 SLC6A4 PRL POMC MAOA HTR2A HTR1A
2 depression 30.2 SLC6A4 MAOA HTR2A HTR1A CRH BDNF
3 diabetes insipidus 30.2 PRL POMC CRH AVPR1B
4 kleptomania 29.8 SLC6A4 MAOA HTR1A
5 dysthymic disorder 29.5 SLC6A4 MAOA HTR2A HTR1A CRH BDNF
6 adjustment disorder 29.5 SLC6A4 HTR2A HTR1A BDNF
7 bipolar i disorder 29.5 SLC6A4 HTR2A HTR1A BDNF
8 mood disorder 29.5 SLC6A4 POMC MAOA HTR2A HTR1A CRH
9 tobacco addiction 29.4 SLC6A4 MAOA HTR2A CRH BDNF
10 constipation 29.4 TNF SLC6A4 HTR2A HTR1A CRP BDNF
11 personality disorder 29.4 SLC6A4 PRL MAOA HTR2A HTR1A CRH
12 asthma 29.2 TNF TF SLC6A4 POMC HP CRH
13 mental depression 29.2 TNF SLC6A4 POMC MAOA HTR2A HTR1A
14 generalized anxiety disorder 28.9 SLC6A4 MAOA HTR2A HTR1A CRP BDNF
15 atypical depressive disorder 28.8 SLC6A4 POMC MAOA HTR2A HTR1A CRP
16 bipolar disorder 28.8 TNF SLC6A4 PRL MAOA HTR2A HTR1A
17 sexual disorder 28.7 SLC6A4 SEMA3F-AS1 PRL POMC HTR2A HTR1A
18 neurotic disorder 28.7 TNF SLC6A4 SEMA3F-AS1 MAOA HTR2A HTR1A
19 borderline personality disorder 28.7 SLC6A4 PRL MAOA HTR2A HTR1A CRH
20 agoraphobia 28.6 SLC6A4 MAOA LOC110806262 HTR2A HTR1A CRH
21 alcohol dependence 28.6 TNF SLC6A4 PRL POMC MAOA HTR2A
22 major depressive disorder 28.4 TNF SLC6A4 PRL POMC MAOA LHPP
23 chronic fatigue syndrome 28.4 TNF SLC6A4 PRL POMC MAOA HTR2A
24 fibromyalgia 28.3 TNF SLC6A4 PRL POMC HTR2A HTR1A
25 anxiety 28.0 TNF SLC6A4 PRL POMC MAOA HTR2A
26 substance abuse 28.0 TF SLC6A4 PRL POMC MAOA HTR2A
27 hypochondriasis 27.8 SLC6A4 POMC MHRT HTR2A HTR1A GRAP2
28 drug reaction with eosinophilia and systemic symptoms 10.5 TNF CRP
29 acquired angioedema 10.5 HP CRP
30 rheumatoid arthritis interstitial lung disease 10.5 TNF CRP
31 posterior scleritis 10.5 TNF CRP
32 major affective disorder 8 10.5
33 major affective disorder 9 10.5
34 mediastinum teratoma 10.5 POMC CRP
35 adenohypophysitis 10.4 PRL POMC
36 haemophilus influenzae 10.4 TNF TF
37 louse-borne relapsing fever 10.4 TNF CRP
38 tuberculum sellae meningioma 10.4 PRL POMC
39 sella turcica neoplasm 10.4 PRL POMC
40 prolactin producing pituitary tumor 10.4 PRL POMC
41 chromophobe adenoma 10.4 PRL POMC
42 radiation proctitis 10.4 TNF TF
43 opportunistic bacterial infectious disease 10.4 TNF CRP
44 cavernous sinus thrombosis 10.4 POMC CRP
45 vaginal discharge 10.4 TNF HP CRP
46 bronchopneumonia 10.4 TNF HP CRP
47 spinocerebellar degeneration 10.4 PRL CRH
48 autoimmune disease of blood 10.4 TNF HP CRP
49 autoimmune disease of gastrointestinal tract 10.4 TNF HP CRP
50 hypothyroidism, congenital, nongoitrous, 4 10.4 PRL POMC

Graphical network of the top 20 diseases related to Melancholia:



Diseases related to Melancholia
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Symptoms & Phenotypes for Melancholia

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MGI Mouse Phenotypes related to Melancholia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.28 AVPR1B BDNF CRH GRAP2 HTR2A POMC
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Drugs & Therapeutics for Melancholia

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Drugs for Melancholia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sertraline Approved Phase 4 79617-96-2 68617
2
Nortriptyline Approved Phase 4 72-69-5 4543
3
Norepinephrine Approved Phase 4 51-41-2 439260
4
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
5
Citalopram Approved Phase 4 59729-33-8 2771
6
Histamine Approved, Investigational Phase 4 51-45-6 774
7
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
8
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
9
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
10
Bupropion Approved Phase 4 34911-55-2, 34841-39-9 444
11 Cytochrome P-450 Enzyme Inhibitors Phase 4
12 Antidepressive Agents Phase 4
13 Psychotropic Drugs Phase 4
14 Anti-Anxiety Agents Phase 4
15 Serotonin Uptake Inhibitors Phase 4
16 Neurotransmitter Agents Phase 4
17 Adrenergic Agents Phase 4
18 Antidepressive Agents, Tricyclic Phase 4
19 Serotonin 5-HT3 Receptor Antagonists Phase 4
20 Dopamine Agents Phase 4
21 Duloxetine Hydrochloride Phase 4
22 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
23 Analgesics Phase 4
24 Antipsychotic Agents Phase 4
25 Adrenergic alpha-Antagonists Phase 4
26 Adrenergic Antagonists Phase 4
27 Histamine Antagonists Phase 4
28 Venlafaxine Hydrochloride Phase 4
29 Desvenlafaxine Succinate Phase 4 386750-22-7
30 Vilazodone Hydrochloride Phase 4 163521-08-2
31
Histamine Phosphate Phase 4 51-74-1 65513
32 Histamine H1 Antagonists Phase 4
33 Quetiapine Fumarate Phase 4 111974-72-2
34
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
35
Vortioxetine Approved, Investigational Phase 3 508233-74-7 9966051
36
Risperidone Approved, Investigational Phase 3 106266-06-2 5073
37 Serotonin 5-HT1 Receptor Agonists Phase 3
38 Serotonin Receptor Agonists Phase 3
39 Dopamine Antagonists Phase 3
40
Fluvoxamine Approved, Investigational Phase 2 54739-18-3 3404 5324346
41 neurokinin A Phase 2
42
Substance P Phase 2 33507-63-0 44359816
43
Hydrocortisone Approved, Vet_approved 50-23-7 5754
44
Hydrocortisone acetate Approved, Vet_approved 50-03-3
45
Epinephrine Approved, Vet_approved 51-43-4 5816
46
Racepinephrine Approved 329-65-7 838
47
Adenosine Approved, Investigational 58-61-7 60961
48 Hormones
49 Adrenocorticotropic Hormone
50 Hydrocortisone 17-butyrate 21-propionate

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Antidepressant Treatment of Melancholia in Late :Ife Completed NCT00000378 Phase 4 Sertraline;Nortriptyline
2 Effects of Treatment on Decision-making in Major Depression Completed NCT01916824 Phase 4 Any FDA Approved Antidepressant
3 Melancholic Depression and Insomnia as Predictors of Response to Quetiapine in Patients With Major Depression Completed NCT03207438 Phase 4 Quetiapine 50 MG Extended Release Oral Tablet;Quetiapine Fumarate XR 150-300 mg;Placebos
4 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study To Evaluate The Efficacy And Safety Of Three Fixed Doses (100 Mg, 200 Mg, Or 400 Mg) Of DVS-233 SR In Adult Outpatients With Major Depressive Disorder Completed NCT00072774 Phase 3 DVS-233 SR
5 A Phase 3, Long-Term, Open-Label, Flexible-Dose, Extension Study Evaluating the Safety and Tolerability of Lu AA21004 (15 and 20 mg) in Subjects With Major Depressive Disorder Completed NCT01152996 Phase 3 Vortioxetine
6 A Long-Term, Open-Label, Flexible-Dose, Extension Study Evaluating the Safety and Tolerability of Lu AA21004 in Subjects With Major Depressive Disorder Completed NCT00707980 Phase 3 Vortioxetine
7 A Phase 3, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Duloxetine-Referenced, Fixed-Dose Study Comparing the Efficacy and Safety of 2 Doses (15 and 20 mg) of Lu AA21004 in Acute Treatment of Adults With Major Depressive Disorder Completed NCT01153009 Phase 3 Vortioxetine;Duloxetine;Placebo
8 A Phase 3, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Fixed-Dose Study Comparing the Efficacy and Safety of 2 Doses (10 and 20 mg) of Lu AA21004 in Acute Treatment of Adults With Major Depressive Disorder Completed NCT01163266 Phase 3 Vortioxetine;Placebo
9 A Randomized, Double-blind, Parallel-Group, Placebo-Controlled, Fixed-Dose Study Comparing the Efficacy and Safety of 3 Doses of Lu AA21004 in Acute Treatment of Adults With Major Depressive Disorder Completed NCT00735709 Phase 3 Vortioxetine;Placebo
10 A Multinational, Randomized, Double-Blind, Placebo-Controlled, Dose Ranging Study to Assess the Efficacy and Safety of Lu AA21004 in Patients With Major Depressive Disorder Completed NCT01255787 Phase 2, Phase 3 Vortioxetine;Placebo
11 A Study to Evaluate the Efficacy, Safety and Maintenance Effect of Risperidone Augmentation of SSRI Monotherapy in Young and Older Adult Patients With Unipolar Treatment-Resistant Depression Completed NCT00044681 Phase 3 risperidone
12 A Double-Blind Sham Controlled Trial of rTMS in the Treatment of Bipolar Depression Unknown status NCT00436020 Phase 2
13 A Six-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Evaluating the Efficacy, Safety, and Tolerability of GSK561679 Compared to Placebo in Female Subjects, Diagnosed With Major Depressive Disorder Completed NCT00733980 Phase 2 GSK561679
14 Serotonin Transporter Density in Late-life Depression With and Without Dementia Completed NCT01548937 Phase 2 I-123 ADAM
15 A Clinical Trial of Fluvoxamine for Melancholia Recruiting NCT04160377 Phase 2 Fluvoxamine
16 A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Fixed Dose Study Evaluating the Efficacy and Safety of Orvepitant in Subjects With Major Depressive Disorder Terminated NCT00880399 Phase 2 orvepitant
17 A Randomised, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Orvepitant in Subjects With Major Depressive Disorder Terminated NCT00880048 Phase 2 orvepitant
18 A Double-Blind Sham Controlled Trial of rTMS in Treatment Resistant Major Depression Unknown status NCT00402220 TMS
19 The Sunlight Improves Depression in Stroke Patients Completed NCT04036565
20 Intensively Sampled Dynamics of ACTH and Cortisol Affective Disorders Completed NCT00001479
21 Understanding the Person, Exploring Change Across Psychotherapies Recruiting NCT04106713
22 Freeman-Sheldon Syndrome Quality of Life Study (FSS-QLS): Cross-sectional Study of Concomitant Disorder-Specific Contributors to Quality of Life and Clinical Outcome Terminated NCT01307475

Search NIH Clinical Center for Melancholia

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Genetic Tests for Melancholia

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Anatomical Context for Melancholia

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MalaCards organs/tissues related to Melancholia:

40
Testes, Brain, Pituitary, Eye, Thyroid, Cortex, Heart
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Publications for Melancholia

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Articles related to Melancholia:

(show top 50) (show all 1389)
# Title Authors PMID Year
1
The ethnopharmacology, phytochemistry, pharmacology and toxicology of genus Albizia: A review. 61
32278761 2020
2
Tracing the Roots of Dementia Praecox: The Emergence of Verrücktheit as a Primary Delusional-Hallucinatory Psychosis in German Psychiatry From 1860 to 1880. 61
32514545 2020
3
Pseudo-melancholia. 61
32157900 2020
4
Dreyfus and the shift of melancholia in Kraepelin's textbooks from an involutional to a manic-depressive illness. 61
32275219 2020
5
Wild melancholy. On the historical plausibility of a black bile theory of blood madness, or hæmatomania. 61
31969026 2020
6
Prediction of Antidepressant Treatment Outcome Using Event-Related Potential in Patients with Major Depressive Disorder. 61
32375213 2020
7
Study of efficacy and safety of Jiaotai pill in the treatment of depression. 61
32358376 2020
8
The characteristic signs and symptoms of mania and depression according to Kraepelin circa 1905: a comparison with DSM-III. 61
32364088 2020
9
Perspective: Aristotle on manic-depressive illness and greatness. 61
32276300 2020
10
Melancholic versus Nonmelancholic Major Depression Compared. 61
32217259 2020
11
The biological face of melancholia: Are there any reliable biomarkers for this depression subtype? 61
32217262 2020
12
The dynamics of grief and melancholia. 61
32238967 2020
13
Melancholia: does this ancient concept have contemporary utility? 61
32172612 2020
14
Meaning and Melancholia: Life in the Age of Bewilderment, by Christopher Bollas, Routledge, Abingdon and New York, 2018, 130 pp. 61
32066848 2020
15
Acylcarnitine metabolomic profiles inform clinically-defined major depressive phenotypes. 61
32056779 2020
16
Melancholic Versus Non-Melancholic Depression: a Prospective Study. 61
32229643 2020
17
Increased Serum Immunoglobulin Responses to Gut Commensal Gram-Negative Bacteria in Unipolar Major Depression and Bipolar Disorder Type 1, Especially When Melancholia Is Present. 61
31802379 2020
18
Differences in the immune-inflammatory profiles of unipolar and bipolar depression. 61
31693974 2020
19
The origin of our modern concept of mania in texts from 1780 to 1900. 61
32034292 2020
20
Cerebral Impaludation - An Ignoble Procedure between Two Nobel Prizes: Frontal Lobe Lesions before the Introduction of Leucotomy. 61
32320974 2020
21
The Origin of Our Modern Concept of Depression-The History of Melancholia From 1780-1880: A Review. 61
31995137 2020
22
Sleep, insomnia, and depression. 61
31071719 2020
23
Switching antidepressants in the treatment of major depression: When, how and what to switch to? 61
31630037 2020
24
Melancholia as Predictor of Electroconvulsive Therapy Outcome in Later Life. 61
31764445 2019
25
Has Oedipus Murdered His Parents? Distinguishing Between "Killing" and "Murdering" One's Parent as Promoting Psychic Growth Versus Melancholia. 61
31526312 2019
26
Pre-Kraepelin Names for Mental Disorders. 61
30720602 2019
27
Melancholia: An Attempt at Definition Based on a Review of Empirical Data. 61
31464990 2019
28
[The melancholy of the philosopher in the Intercenales (1424-1439)]. 61
31859971 2019
29
Hormonal Dynamics Effect of Serum Insulin-Like Growth Factor I and Cortisol/Dehydroepiandrosterone Sulfate Ratio on Symptom Severity of Major Depressive Disorder. 61
31211752 2019
30
Results of the European Group for the Study of Resistant Depression (GSRD) - basis for further research and clinical practice. 61
31340696 2019
31
Emotional asymmetries in refractory medial temporal and frontal lobe epilepsy: Their impact on predicting lateralization and localization of seizures. 61
30981983 2019
32
Transitions across Melancholia States in a Climate Model: Reconciling the Deterministic and Stochastic Points of View. 61
31050495 2019
33
Lost to Himself: Narcissus and Freud's Theory of Narcissism Reinterpreted. 61
30977705 2019
34
Melancholia as Predictor of Electroconvulsive Therapy Outcome in Later Life. 61
30844880 2019
35
Trajectories of Symptom Change in the Treatment for Adolescents With Depression Study. 61
30768414 2019
36
A Cross-Cultural Comparison of Climacteric Symptoms, Health-Seeking Behavior, and Attitudes towards Menopause Among Mosuo Women and Han Chinese Women in Yunnan, China. 61
30444458 2019
37
Identifying and differentiating melancholic depression in a non-clinical sample. 61
30245251 2019
38
The mysterious "mental illness" of a philosopher: the case of Blaise Pascal. 61
32239123 2019
39
Citing Hippocrates on depression in epilepsy. 61
30500486 2019
40
Proximity Bias Following Affective Metaphors in Patients With Depression-Psychoanalytic Considerations. 61
31780981 2019
41
Hamlet and psychiatry intertwined. 61
29847995 2018
42
The Effect of Memory in Inducing Pleasant Emotions with Musical and Pictorial Stimuli. 61
30518885 2018
43
Historical precedents for the DSM-III bereavement exclusion criteria for major depression. 61
29554991 2018
44
Personality Correlates of Self-Injury in Adolescent Girls: Disentangling the Effects of Lifetime Psychopathology. 61
29488108 2018
45
And I feel fine: Melancholia. 61
30401449 2018
46
Disturbances of intentionality in schizophrenia and in depression. 61
30552813 2018
47
Treating depression with adjunctive antipsychotics. 61
30328223 2018
48
Historical and conceptual aspects of motor disorders in the psychoses. 61
28941779 2018
49
Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders. 61
29807322 2018
50
Views from an asylum: a retrospective case note analysis of a nineteenth century asylum. 61
30083986 2018
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Variations for Melancholia

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Expression for Melancholia

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Search GEO for disease gene expression data for Melancholia.
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Pathways for Melancholia

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Pathways related to Melancholia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Serotonergic synapse 36
11.62 SLC6A4 MAOA HTR2A HTR1A
2
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.38 TNF TF SLC6A4 MAOA HTR2A HTR1A
3
Monoamine Transport 1
Show member pathways
 11.13 TNF SLC6A4 MAOA
4
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics 60
10.7 SLC6A4 MAOA HTR2A HTR1A
5
Methylphenidate Pathway, Pharmacodynamics 60
Show member pathways
 10.69 SLC6A4 MAOA HTR1A
6
EV release from cardiac cells and their functional effects 1
10.36 TNF PRL
7
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics 60
10.21 POMC CRH
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GO Terms for Melancholia

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Cellular components related to Melancholia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 TNF TF PRL POMC HP CRP

Biological processes related to Melancholia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to organic substance GO:0010033 9.54 TNF SLC6A4 HP
2 memory GO:0007613 9.5 SLC6A4 HTR2A BDNF
3 negative regulation of lipid storage GO:0010888 9.26 TNF CRP
4 serotonin receptor signaling pathway GO:0007210 9.16 HTR2A HTR1A
5 activation of phospholipase C activity GO:0007202 9.13 HTR2A BDNF AVPR1B
6 regulation of serotonin secretion GO:0014062 8.62 HTR1A CRH

Molecular functions related to Melancholia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serotonin binding GO:0051378 8.8 SLC6A4 HTR2A HTR1A
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Sources for Melancholia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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