MCID: MLN005
MIFTS: 30

Melanoacanthoma

Categories: Skin diseases

Aliases & Classifications for Melanoacanthoma

MalaCards integrated aliases for Melanoacanthoma:

Name: Melanoacanthoma 12 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:11684
NCIt 51 C27548
UMLS 74 C1321683

Summaries for Melanoacanthoma

MalaCards based summary : Melanoacanthoma is related to acanthoma and melanoma. An important gene associated with Melanoacanthoma is MCM5 (Minichromosome Maintenance Complex Component 5), and among its related pathways/superpathways are Cell Cycle Checkpoints and Mitotic G1-G1/S phases. Affiliated tissues include skin, breast and cervix, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 77 Melanoacanthoma (also known as "Pigmented seborrheic keratosis") is a common, benign, darkly pigmented... more...

Related Diseases for Melanoacanthoma

Graphical network of the top 20 diseases related to Melanoacanthoma:



Diseases related to Melanoacanthoma

Symptoms & Phenotypes for Melanoacanthoma

GenomeRNAi Phenotypes related to Melanoacanthoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 GMNN MCM2 MCM5 MCM7 PMEL
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 GMNN MCM2 MCM5 MCM7 PMEL
3 Increased Nanog expression GR00371-A-1 9.35 GMNN MCM5 MCM7
4 Increased Nanog expression GR00371-A-3 9.35 GMNN MCM5

MGI Mouse Phenotypes related to Melanoacanthoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 8.92 MCM2 MLANA PMEL TYR

Drugs & Therapeutics for Melanoacanthoma

Search Clinical Trials , NIH Clinical Center for Melanoacanthoma

Genetic Tests for Melanoacanthoma

Anatomical Context for Melanoacanthoma

MalaCards organs/tissues related to Melanoacanthoma:

42
Skin, Breast, Cervix

Publications for Melanoacanthoma

Articles related to Melanoacanthoma:

(show top 50) (show all 54)
# Title Authors Year
1
Clinical and histopathological study of the oral multifocal melanoacanthoma: A case report. ( 31110620 )
2019
2
Oral melanoacanthoma of the palate: An unusual presentation of an uncommon entity. ( 29387765 )
2018
3
Gingival melanoacanthoma associated with pseudomelanocytic nests: Expanding the clinicopathological spectrum of a recently described oral lesion. ( 29752741 )
2018
4
A rare case of oral melanoacanthoma. ( 30651689 )
2018
5
Multifocal oral melanoacanthoma associated with Addison's disease and hyperthyroidism: a case report. ( 28658350 )
2017
6
Melanoacanthoma on the genital region of a young woman. ( 27421241 )
2017
7
Verrucous melanoma simulating melanoacanthoma: Dermoscopic, reflectance confocal microscopic and high-definition optical coherence tomography presentation of a rare melanoma variant. ( 26820787 )
2016
8
Pathogenesis and clinicohistopathological caractheristics of melanoacanthoma: A systematic review. ( 27398186 )
2016
9
In vivo reflectance confocal microscopy features of a melanoacanthoma. ( 27867743 )
2016
10
Clinical and Dermoscopic Features of Cutaneous Melanoacanthoma. ( 26083708 )
2015
11
Immunohistochemical features of multifocal melanoacanthoma in the hard palate: a case report. ( 23356913 )
2013
12
Diagnostic discussion. Melanoacanthoma. ( 23513945 )
2013
13
Melanoacanthoma: Uncommon presentation of an uncommon condition. ( 23741670 )
2013
14
Melanoacanthoma of external ear: report of two cases. ( 24014974 )
2013
15
An unusual clinical presentation of gingival melanoacanthoma. ( 24174763 )
2013
16
Oral melanoacanthoma of a rare intraoral site: case report and review of literature. ( 25206187 )
2013
17
Oral melanoacanthoma: A rare case of diffuse oral pigmentation. ( 23248484 )
2012
18
Multifocal pigmentation of the oral cavity. Oral melanoacanthoma. ( 21193767 )
2011
19
Bilateral oral melanoacanthoma in an Indian boy. ( 21393961 )
2011
20
Gingival melanoacanthoma: case report and discussion of its clinical relevance. ( 21465013 )
2011
21
Giant melanoacanthoma mimicking malignant melanoma. ( 21572799 )
2011
22
Multifocal oral melanoacanthoma and melanotic macula in a patient after dental implant surgery. ( 21719804 )
2011
23
Multifocal cutaneous melanoacanthoma with ulceration: a case report with review of literature. ( 22016278 )
2011
24
Oral melanoacanthoma in an adolescent. ( 20653859 )
2010
25
Oral melanoacanthoma: a case report and review of the literature. ( 19144105 )
2009
26
Multifocal melanoacanthoma of the gingiva and hard palate. ( 19254138 )
2009
27
Multifocal diffuse oral melanoacanthoma: a case report. ( 19776516 )
2009
28
Gingival pigmentation of recent origin. Oral melanoacanthoma. ( 18254569 )
2008
29
A Case of Melanoacanthoma: Immunohistochemical Staining Using VECTOR® NovaRED™ to Distinguish Melanocytes from the Cutaneous Pigment. ( 27303152 )
2008
30
Oral melanoacanthoma and oral melanotic macule: a report of 8 cases, review of the literature, and immunohistochemical analysis. ( 17767102 )
2007
31
Melanoacanthoma of the external auditory canal: a case report and review of the literature. ( 17980780 )
2007
32
Solitary and multifocal oral melanoacanthoma. ( 18173514 )
2007
33
Melanoacanthoma simulating pigmented spitz nevus: an unusual dermoscopy pitfall. ( 16706772 )
2006
34
Oral melanoacanthoma: a case report, a review of the literature, and a new treatment option. ( 16240929 )
2005
35
Giant cutaneous melanoacanthoma. ( 15569024 )
2004
36
Oral melanoacanthoma: a report of 10 cases, review of the literature, and immunohistochemical analysis for HMB-45 reactivity. ( 12544093 )
2003
37
Oral melanoacanthoma of the attached gingiva. ( 11763954 )
2000
38
Bilateral oral melanoacanthoma. ( 9171047 )
1996
39
How rare is melanoacanthoma? ( 2006888 )
1991
40
Melanoacanthosis (melanoacanthoma) of the oral mucosa. ( 2179347 )
1990
41
Oral melanoacanthoma with prominent spongiotic intraepithelial vesicles. ( 2613950 )
1989
42
Melanoacanthoma of the penis shaft. Report of a case. ( 2792496 )
1989
43
Intraoral melanoacanthoma: a reactive melanocytic hyperplasia. Case report. ( 3422293 )
1988
44
Melanoacanthoma and related disorders. Simulants of acral-lentiginous (P-P-S-M) melanoma. ( 3316075 )
1987
45
Intraoral melanoacanthoma. ( 6482463 )
1984
46
Intraoral melanoacanthoma. ( 6572716 )
1983
47
Oral melanoacanthoma. Review of the literature and report of ten cases. ( 6581460 )
1983
48
Melanoacanthoma of the lip. ( 7082014 )
1982
49
Melanoacanthoma of the oral mucosa. ( 6945539 )
1981
50
Melanoacanthoma of the lip. ( 485190 )
1979

Variations for Melanoacanthoma

Expression for Melanoacanthoma

Search GEO for disease gene expression data for Melanoacanthoma.

Pathways for Melanoacanthoma

GO Terms for Melanoacanthoma

Cellular components related to Melanoacanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromosome, telomeric region GO:0000784 9.33 MCM2 MCM5 MCM7
2 melanosome GO:0042470 9.13 MLANA PMEL TYR
3 MCM complex GO:0042555 8.8 MCM2 MCM5 MCM7

Biological processes related to Melanoacanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell cycle GO:0007049 9.67 GMNN MCM2 MCM5 MCM7
2 DNA replication GO:0006260 9.5 MCM2 MCM5 MCM7
3 melanin biosynthetic process GO:0042438 9.26 PMEL TYR
4 DNA unwinding involved in DNA replication GO:0006268 9.16 MCM2 MCM7
5 DNA replication initiation GO:0006270 9.13 MCM2 MCM5 MCM7
6 G1/S transition of mitotic cell cycle GO:0000082 8.92 GMNN MCM2 MCM5 MCM7

Molecular functions related to Melanoacanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.33 MCM2 MCM5 MCM7
2 DNA replication origin binding GO:0003688 8.96 MCM2 MCM5
3 helicase activity GO:0004386 8.8 MCM2 MCM5 MCM7

Sources for Melanoacanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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