Aliases & Classifications for Melanoacanthoma

MalaCards integrated aliases for Melanoacanthoma:

Name: Melanoacanthoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11684
NCIt 50 C27548
SNOMED-CT 68 201096007 394727000
UMLS 73 C1321683

Summaries for Melanoacanthoma

MalaCards based summary : Melanoacanthoma is related to acanthoma and genitourinary tract anomalies. An important gene associated with Melanoacanthoma is MCM5 (Minichromosome Maintenance Complex Component 5), and among its related pathways/superpathways are Cell Cycle Checkpoints and Mitotic G1-G1/S phases. Affiliated tissues include skin, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Melanoacanthoma (also known as \"Pigmented seborrheic keratosis\") is a common, benign, darkly pigmented... more...

Related Diseases for Melanoacanthoma

Diseases related to Melanoacanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 acanthoma 11.0
2 genitourinary tract anomalies 10.5 GMNN MCM5
3 tuberculous empyema 10.2 CEACAM5 SALL1
4 gingivitis 10.1
5 malignant spindle cell melanoma 10.1 PMEL TYR
6 melanoma 10.1
7 gallbladder melanoma 10.0 MLANA PMEL
8 meier-gorlin syndrome 1 10.0 GMNN MCM5
9 pigmented basal cell carcinoma 9.9 MLANA TYR
10 epithelioid cell melanoma 9.9 MLANA TYR
11 breast angiosarcoma 9.9 MLANA TYR
12 hermansky-pudlak syndrome 3 9.9 PMEL TYR
13 lentigines 9.8
14 keratosis 9.8
15 hyperthyroidism 9.8
16 laugier-hunziker syndrome 9.8
17 spitz nevus 9.8
18 testicular granulosa cell tumor 9.8 CEACAM5 MLANA
19 juvenile type testicular granulosa cell tumor 9.8 CEACAM5 MLANA
20 vulvar melanoma 9.8 MLANA TYR
21 infiltrative basal cell carcinoma 9.8 CEACAM5 MLANA
22 malignant skin fibrous histiocytoma 9.7 MLANA TYR
23 malignant dermis tumor 9.6 MLANA TYR
24 halo nevi 9.5 MLANA PMEL TYR
25 melanotic neurilemmoma 9.5 MLANA PMEL TYR
26 diffuse meningeal melanocytosis 9.5 MLANA PMEL TYR
27 central nervous system melanocytic neoplasm 9.5 MLANA PMEL TYR
28 vitiligo-associated multiple autoimmune disease susceptibility 1 9.4 MLANA PMEL TYR
29 vogt-koyanagi-harada disease 9.4 PMEL TYR
30 melanoma, uveal 9.4 MLANA PMEL TYR
31 skin melanoma 9.4 MLANA PMEL TYR
32 integumentary system cancer 9.4 CEACAM5 MLANA TYR
33 cervix endometriosis 9.3 CEACAM5 MCM2 MCM7
34 microphthalmia 9.0 MLANA PMEL SALL1 TYR
35 cell type cancer 8.9 CEACAM5 MLANA PMEL TYR

Graphical network of the top 20 diseases related to Melanoacanthoma:



Diseases related to Melanoacanthoma

Symptoms & Phenotypes for Melanoacanthoma

GenomeRNAi Phenotypes related to Melanoacanthoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 GMNN MCM2 MCM5 MCM7 PMEL
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 PMEL GMNN MCM2 MCM5 MCM7
3 Increased Nanog expression GR00371-A-1 9.35 GMNN MCM5 MCM7
4 Increased Nanog expression GR00371-A-3 9.35 GMNN MCM5

MGI Mouse Phenotypes related to Melanoacanthoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 8.92 MCM2 MLANA PMEL TYR

Drugs & Therapeutics for Melanoacanthoma

Search Clinical Trials , NIH Clinical Center for Melanoacanthoma

Genetic Tests for Melanoacanthoma

Anatomical Context for Melanoacanthoma

MalaCards organs/tissues related to Melanoacanthoma:

41
Skin

Publications for Melanoacanthoma

Articles related to Melanoacanthoma:

(show top 50) (show all 52)
# Title Authors Year
1
Laugier-Hunziker Syndrome Presenting with Metachronous Melanoacanthomas. ( 29450847 )
2018
2
Oral melanoacanthoma of the palate: An unusual presentation of an uncommon entity. ( 29387765 )
2018
3
Gingival melanoacanthoma associated with pseudomelanocytic nests: Expanding the clinicopathological spectrum of a recently described oral lesion. ( 29752741 )
2018
4
Multifocal oral melanoacanthoma associated with Addison's disease and hyperthyroidism: a case report. ( 28658350 )
2017
5
Verrucous melanoma simulating melanoacanthoma: Dermoscopic, reflectance confocal microscopic and high-definition optical coherence tomography presentation of a rare melanoma variant. ( 26820787 )
2016
6
Melanoacanthoma on the genital region of a young woman. ( 27421241 )
2016
7
In vivo reflectance confocal microscopy features of a melanoacanthoma. ( 27867743 )
2016
8
Pathogenesis and clinicohistopathological caractheristics of melanoacanthoma: A systematic review. ( 27398186 )
2016
9
Clinical and Dermoscopic Features of Cutaneous Melanoacanthoma. ( 26083708 )
2015
10
An unusual clinical presentation of gingival melanoacanthoma. ( 24174763 )
2013
11
Melanoacanthoma: Uncommon presentation of an uncommon condition. ( 23741670 )
2013
12
Oral melanoacanthoma of a rare intraoral site: case report and review of literature. ( 25206187 )
2013
13
Diagnostic discussion. Melanoacanthoma. ( 23513945 )
2013
14
Immunohistochemical features of multifocal melanoacanthoma in the hard palate: a case report. ( 23356913 )
2013
15
Melanoacanthoma of external ear: report of two cases. ( 24014974 )
2013
16
Oral melanoacanthoma: A rare case of diffuse oral pigmentation. ( 23248484 )
2012
17
Multifocal cutaneous melanoacanthoma with ulceration: a case report with review of literature. ( 22016278 )
2011
18
Multifocal oral melanoacanthoma and melanotic macula in a patient after dental implant surgery. ( 21719804 )
2011
19
Gingival melanoacanthoma: case report and discussion of its clinical relevance. ( 21465013 )
2011
20
Bilateral oral melanoacanthoma in an Indian boy. ( 21393961 )
2011
21
Multifocal pigmentation of the oral cavity. Oral melanoacanthoma. ( 21193767 )
2011
22
Giant melanoacanthoma mimicking malignant melanoma. ( 21572799 )
2011
23
Oral melanoacanthoma in an adolescent. ( 20653859 )
2010
24
Multifocal melanoacanthoma of the gingiva and hard palate. ( 19254138 )
2009
25
Multifocal diffuse oral melanoacanthoma: a case report. ( 19776516 )
2009
26
Oral melanoacanthoma: a case report and review of the literature. ( 19144105 )
2009
27
Gingival pigmentation of recent origin. Oral melanoacanthoma. ( 18254569 )
2008
28
Oral melanoacanthoma and oral melanotic macule: a report of 8 cases, review of the literature, and immunohistochemical analysis. ( 17767102 )
2007
29
Solitary and multifocal oral melanoacanthoma. ( 18173514 )
2007
30
Melanoacanthoma of the external auditory canal: a case report and review of the literature. ( 17980780 )
2007
31
Melanoacanthoma simulating pigmented spitz nevus: an unusual dermoscopy pitfall. ( 16706772 )
2006
32
Oral melanoacanthoma: a case report, a review of the literature, and a new treatment option. ( 16240929 )
2005
33
Giant cutaneous melanoacanthoma. ( 15569024 )
2004
34
Oral melanoacanthoma: a report of 10 cases, review of the literature, and immunohistochemical analysis for HMB-45 reactivity. ( 12544093 )
2003
35
Oral melanoacanthoma of the attached gingiva. ( 11763954 )
2000
36
Bilateral oral melanoacanthoma. ( 9171047 )
1996
37
How rare is melanoacanthoma? ( 2006888 )
1991
38
Melanoacanthosis (melanoacanthoma) of the oral mucosa. ( 2179347 )
1990
39
Melanoacanthoma of the penis shaft. Report of a case. ( 2792496 )
1989
40
Oral melanoacanthoma with prominent spongiotic intraepithelial vesicles. ( 2613950 )
1989
41
Intraoral melanoacanthoma: a reactive melanocytic hyperplasia. Case report. ( 3422293 )
1988
42
Melanoacanthoma and related disorders. Simulants of acral-lentiginous (P-P-S-M) melanoma. ( 3316075 )
1987
43
Intraoral melanoacanthoma. ( 6482463 )
1984
44
Oral melanoacanthoma. Review of the literature and report of ten cases. ( 6581460 )
1983
45
Intraoral melanoacanthoma. ( 6572716 )
1983
46
Melanoacanthoma of the lip. ( 7082014 )
1982
47
Melanoacanthoma of the oral mucosa. ( 6945539 )
1981
48
Melanoacanthoma of the lip. ( 485190 )
1979
49
Melanoacanthoma. Ultrastructural and immunological studies. ( 210197 )
1978
50
Melanoacanthoma of the eyelid. ( 5039745 )
1972

Variations for Melanoacanthoma

Expression for Melanoacanthoma

Search GEO for disease gene expression data for Melanoacanthoma.

Pathways for Melanoacanthoma

GO Terms for Melanoacanthoma

Cellular components related to Melanoacanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromosome, telomeric region GO:0000784 9.33 MCM2 MCM5 MCM7
2 melanosome GO:0042470 9.13 MLANA PMEL TYR
3 MCM complex GO:0042555 8.8 MCM2 MCM5 MCM7

Biological processes related to Melanoacanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell cycle GO:0007049 9.71 GMNN MCM2 MCM5 MCM7
2 DNA replication GO:0006260 9.54 MCM2 MCM5 MCM7
3 G1/S transition of mitotic cell cycle GO:0000082 9.43 MCM2 MCM5 MCM7
4 melanin biosynthetic process GO:0042438 9.32 PMEL TYR
5 DNA unwinding involved in DNA replication GO:0006268 9.16 MCM2 MCM7
6 DNA duplex unwinding GO:0032508 9.13 MCM2 MCM5 MCM7
7 DNA replication initiation GO:0006270 8.8 MCM2 MCM5 MCM7

Molecular functions related to Melanoacanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.43 MCM2 MCM5 MCM7
2 helicase activity GO:0004386 9.33 MCM2 MCM5 MCM7
3 DNA replication origin binding GO:0003688 8.96 MCM2 MCM5
4 DNA helicase activity GO:0003678 8.8 MCM2 MCM5 MCM7

Sources for Melanoacanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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45 MESH via Orphanet
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49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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