Melanoma, Cutaneous Malignant 3 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

CMM3 MCID: MLN075 MIFTS: 25	Melanoma, Cutaneous Malignant 3 (CMM3) Categories: Cancer diseases, Genetic diseases, Nephrological diseases, Rare diseases, Skin diseases
Genes Variations Related diseases Publications Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Melanoma, Cutaneous Malignant 3

MalaCards integrated aliases for Melanoma, Cutaneous Malignant 3:

Name: Melanoma, Cutaneous Malignant 3 ⁵⁷ ⁷²

Cutaneous Malignant Melanoma 3 ⁷² ²⁹ ⁶

Melanoma, Cutaneous Malignant, 3 ⁵⁷ ¹³

Cmm3 ⁵⁷ ⁷²

Melanoma, Cutaneous, Malignant, Susceptibility to, Type 3 ³⁹

Melanoma, Cutaneous Malignant, Susceptibility to, 3 ⁵⁷

Characteristics:

OMIM®:

⁵⁷ (Updated 05-Apr-2021)

Inheritance:
autosomal dominant

Miscellaneous:
onset before 50 years of age

HPO:

³¹

melanoma, cutaneous malignant 3:
Inheritance autosomal dominant inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases Cancer diseases Rare diseases
Anatomical: Skin diseases Nephrological diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM® ⁵⁷ 609048

OMIM Phenotypic Series ⁵⁷ PS155600

MeSH ⁴⁴ D008545

MedGen ⁴¹ C1836892

SNOMED-CT via HPO ⁶⁸ 2092003 254818000 263681008 more

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Summaries for Melanoma, Cutaneous Malignant 3

OMIM® : ⁵⁷ Malignant melanoma is a neoplasm of pigment-producing cells called melanocytes that occurs most often in the skin, but may also occur in the eyes, ears, gastrointestinal tract, leptomeninges, and oral and genital mucous membranes (summary by Habif, 2010). For a discussion of genetic heterogeneity of malignant melanoma, see 155600. (609048) (Updated 05-Apr-2021)

MalaCards based summary : Melanoma, Cutaneous Malignant 3, also known as cutaneous malignant melanoma 3, is related to melanoma. An important gene associated with Melanoma, Cutaneous Malignant 3 is CDK4 (Cyclin Dependent Kinase 4). Related phenotypes are cutaneous melanoma and numerous nevi

UniProtKB/Swiss-Prot : ⁷² Melanoma, cutaneous malignant 3: A malignant neoplasm of melanocytes, arising de novo or from a pre- existing benign nevus, which occurs most often in the skin but also may involve other sites.

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Related Diseases for Melanoma, Cutaneous Malignant 3

Diseases in the Melanoma, Cutaneous Malignant 1 family:

Melanoma, Cutaneous Malignant 2	Melanoma, Cutaneous Malignant 4
Melanoma, Cutaneous Malignant 3	Melanoma, Cutaneous Malignant 7
Melanoma, Cutaneous Malignant 5	Melanoma, Cutaneous Malignant 6
Melanoma, Cutaneous Malignant 8	Melanoma, Cutaneous Malignant 9
Melanoma, Cutaneous Malignant 10

Diseases related to Melanoma, Cutaneous Malignant 3 via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	melanoma	10.0

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Symptoms & Phenotypes for Melanoma, Cutaneous Malignant 3

Human phenotypes related to Melanoma, Cutaneous Malignant 3:

³¹

#	Description	HPO Source Accession
1	cutaneous melanoma ³¹	HP:0012056
2	numerous nevi ³¹	HP:0001054
3	atypical nevus ³¹	HP:0001062
4	atypical nevi in non-sun exposed areas ³¹	HP:0001074

Symptoms via clinical synopsis from OMIM®:

⁵⁷ (Updated 05-Apr-2021)

Skin Nails Hair Skin:
numerous nevi
atypical nevi (>5mm with irregular edge and pigmentation)
atypical nevi often present in non-sun exposed areas

Neoplasia:
malignant melanoma

Clinical features from OMIM®:

609048 (Updated 05-Apr-2021)

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Drugs & Therapeutics for Melanoma, Cutaneous Malignant 3

Search Clinical Trials , NIH Clinical Center for Melanoma, Cutaneous Malignant 3

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Genetic Tests for Melanoma, Cutaneous Malignant 3

Genetic tests related to Melanoma, Cutaneous Malignant 3:

#	Genetic test	Affiliating Genes
1	Cutaneous Malignant Melanoma 3 ²⁹	CDK4

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Anatomical Context for Melanoma, Cutaneous Malignant 3

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Publications for Melanoma, Cutaneous Malignant 3

Articles related to Melanoma, Cutaneous Malignant 3:

#	Title	Authors	PMID	Year
1	A large Norwegian family with inherited malignant melanoma, multiple atypical nevi, and CDK4 mutation. ⁵⁷ ⁶	Molven A...Akslen LA	15880589	2005
2	Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group. ⁶ ⁵⁷	Soufir N...Bressac-de Paillerets B	9425228	1998
3	Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. ⁶ ⁵⁷	Zuo L...Dracopoli NC	8528263	1996
4	A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. ⁵⁷ ⁶	Wolfel T...Beach D	7652577	1995
5	[Familial incidence of malignant melanoma]. ⁶ ⁵⁷	Grimstvedt M	5377176	1969
6	Melanoma prone families with CDK4 germline mutation: phenotypic profile and associations with MC1R variants. ⁶	Puntervoll HE...Molven A	23384855	2013
7	MC1R variation and melanoma risk in relation to host/clinical and environmental factors in CDKN2A positive and negative melanoma patients. ⁶	Ghiorzo P...Queirolo P	22804906	2012
8	Identification of CDK4 sequences involved in cyclin D1 and p16 binding. ⁶	Coleman KG...Webster KR	9228064	1997
9	MicroRNA Expression in Formalin-Fixed, Paraffin-Embedded Samples of Canine Cutaneous and Oral Melanoma by RT-qPCR. ⁶¹	Zamarian V...Lecchi C	31526125	2019
10	Combination cytotoxic chemotherapy with CCNU, procarbazine, and vincristine in disseminated cutaneous malignant melanoma: 3 years, followup. ⁶¹	Carmo-Pereira J...Henriques E	7379048	1980

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Genes for Melanoma, Cutaneous Malignant 3

Genes related to Melanoma, Cutaneous Malignant 3 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1392.09	Molecular basis known ⁵⁷ Pathogenic ⁶ Causative variation ⁷² Genetic Tests ²⁹ Susceptibility factor ⁵⁷ Risk factor ⁶ GeneCards inferred via : Disorders Variants (show sections)	7652577 8528263 9228064 (more) 22804906 23384855 9425228 5377176 15880589

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Variations for Melanoma, Cutaneous Malignant 3

ClinVar genetic disease variations for Melanoma, Cutaneous Malignant 3:

⁶ (show top 50) (show all 62)

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	CDK4	NM_000075.4(CDK4):c.70C>T (p.Arg24Cys)	SNV	Pathogenic	16928	rs11547328	GRCh37: 12:58145431-58145431 GRCh38: 12:57751648-57751648
2	CDK4	NM_000075.4(CDK4):c.71G>A (p.Arg24His)	SNV	risk factor	16929	rs104894340	GRCh37: 12:58145430-58145430 GRCh38: 12:57751647-57751647
3	CDK4 , TSPAN31	NM_000075.4(CDK4):c.763C>T (p.Arg255Cys)	SNV	Conflicting interpretations of pathogenicity	133877	rs587778188	GRCh37: 12:58143021-58143021 GRCh38: 12:57749238-57749238
4	CDK4	NM_000075.4(CDK4):c.122A>G (p.Asn41Ser)	SNV	Conflicting interpretations of pathogenicity	135822	rs144890720	GRCh37: 12:58145379-58145379 GRCh38: 12:57751596-57751596
5	CDK4 , TSPAN31	NM_000075.4(CDK4):c.776C>T (p.Ser259Leu)	SNV	Uncertain significance	127520	rs201617914	GRCh37: 12:58143008-58143008 GRCh38: 12:57749225-57749225
6	CDK4 , TSPAN31	NM_000075.4(CDK4):c.764G>A (p.Arg255His)	SNV	Uncertain significance	184333	rs144657355	GRCh37: 12:58143020-58143020 GRCh38: 12:57749237-57749237
7	CDK4 , TSPAN31	NM_000075.4(CDK4):c.661G>A (p.Asp221Asn)	SNV	Uncertain significance	133876	rs587778187	GRCh37: 12:58143259-58143259 GRCh38: 12:57749476-57749476
8	CDK4	NM_000075.4(CDK4):c.625C>T (p.Arg209Cys)	SNV	Uncertain significance	135825	rs140644696	GRCh37: 12:58144446-58144446 GRCh38: 12:57750663-57750663
9	CDK4	NM_000075.4(CDK4):c.364C>T (p.Arg122Cys)	SNV	Uncertain significance	133874	rs587778185	GRCh37: 12:58144864-58144864 GRCh38: 12:57751081-57751081
10	CDK4	NM_000075.4(CDK4):c.520G>A (p.Val174Met)	SNV	Uncertain significance	184906	rs780052789	GRCh37: 12:58144708-58144708 GRCh38: 12:57750925-57750925
11	CDK4 , TSPAN31	NM_000075.4(CDK4):c.898G>A (p.Gly300Ser)	SNV	Uncertain significance	246400	rs879254241	GRCh37: 12:58142322-58142322 GRCh38: 12:57748539-57748539
12	CDK4	NM_000075.4(CDK4):c.132_143del (p.Gly45_Gly48del)	Deletion	Uncertain significance	419254	rs749094206	GRCh37: 12:58145358-58145369 GRCh38: 12:57751575-57751586
13	CDK4 , TSPAN31	NM_000075.4(CDK4):c.779T>A (p.Val260Glu)	SNV	Uncertain significance	182405	rs200215596	GRCh37: 12:58143005-58143005 GRCh38: 12:57749222-57749222
14	CDK4 , TSPAN31	NM_000075.4(CDK4):c.841C>T (p.His281Tyr)	SNV	Uncertain significance	483309	rs876659522	GRCh37: 12:58142379-58142379 GRCh38: 12:57748596-57748596
15	CDK4 , TSPAN31	NM_000075.4(CDK4):c.689T>C (p.Ile230Thr)	SNV	Uncertain significance	220339	rs760435132	GRCh37: 12:58143095-58143095 GRCh38: 12:57749312-57749312
16	CDK4 , TSPAN31	NM_000075.4(CDK4):c.747T>C (p.Phe249=)	SNV	Uncertain significance	309978	rs886049713	GRCh37: 12:58143037-58143037 GRCh38: 12:57749254-57749254
17	CDK4 , TSPAN31	NM_000075.4(CDK4):c.*479T>C	SNV	Uncertain significance	309970	rs886049710	GRCh37: 12:58141829-58141829 GRCh38: 12:57748046-57748046
18	CDK4 , TSPAN31	NM_000075.4(CDK4):c.*689C>T	SNV	Uncertain significance	309967	rs886049709	GRCh37: 12:58141619-58141619 GRCh38: 12:57747836-57747836
19	CDK4 , TSPAN31	NM_000075.4(CDK4):c.690T>C (p.Ile230=)	SNV	Uncertain significance	309979	rs886049714	GRCh37: 12:58143094-58143094 GRCh38: 12:57749311-57749311
20	CDK4 , TSPAN31	NM_000075.4(CDK4):c.*246G>T	SNV	Uncertain significance	309976	rs763088789	GRCh37: 12:58142062-58142062 GRCh38: 12:57748279-57748279
21	CDK4 , TSPAN31	NM_000075.4(CDK4):c.*319G>A	SNV	Uncertain significance	309973	rs775370483	GRCh37: 12:58141989-58141989 GRCh38: 12:57748206-57748206
22	CDK4	NM_000075.4(CDK4):c.-100G>T	SNV	Uncertain significance	309984	rs886049718	GRCh37: 12:58146038-58146038 GRCh38: 12:57752255-57752255
23	CDK4	NM_000075.4(CDK4):c.-54C>T	SNV	Uncertain significance	309981	rs886049716	GRCh37: 12:58145992-58145992 GRCh38: 12:57752209-57752209
24	CDK4	NM_000075.4(CDK4):c.505_522+5del	Deletion	Uncertain significance	548744	rs1555201295	GRCh37: 12:58144701-58144723 GRCh38: 12:57750918-57750940
25	CDK4	NM_000075.4(CDK4):c.155G>T (p.Ser52Ile)	SNV	Uncertain significance	584827	rs760719270	GRCh37: 12:58145346-58145346 GRCh38: 12:57751563-57751563
26	CDK4	NM_000075.4(CDK4):c.133G>C (p.Gly45Arg)	SNV	Uncertain significance	584828	rs876660318	GRCh37: 12:58145368-58145368 GRCh38: 12:57751585-57751585
27	CDK4	NM_000075.4(CDK4):c.-55A>T	SNV	Uncertain significance	309982	rs886049717	GRCh37: 12:58145993-58145993 GRCh38: 12:57752210-57752210
28	CDK4 , TSPAN31	NM_000075.4(CDK4):c.*690G>A	SNV	Uncertain significance	309966	rs886049708	GRCh37: 12:58141618-58141618 GRCh38: 12:57747835-57747835
29	CDK4 , TSPAN31	NM_000075.4(CDK4):c.*734C>T	SNV	Uncertain significance	882173		GRCh37: 12:58141574-58141574 GRCh38: 12:57747791-57747791
30	CDK4	NM_000075.4(CDK4):c.-74C>T	SNV	Uncertain significance	882224		GRCh37: 12:58146012-58146012 GRCh38: 12:57752229-57752229
31	CDK4 , TSPAN31	NM_000075.4(CDK4):c.*424G>A	SNV	Uncertain significance	882420		GRCh37: 12:58141884-58141884 GRCh38: 12:57748101-57748101
32	CDK4 , TSPAN31	NM_000075.4(CDK4):c.*333T>C	SNV	Uncertain significance	884128		GRCh37: 12:58141975-58141975 GRCh38: 12:57748192-57748192
33	CDK4 , TSPAN31	NM_000075.4(CDK4):c.*271A>G	SNV	Uncertain significance	884129		GRCh37: 12:58142037-58142037 GRCh38: 12:57748254-57748254
34	CDK4	NM_000075.4(CDK4):c.-123T>G	SNV	Uncertain significance	309985	rs759319348	GRCh37: 12:58146061-58146061 GRCh38: 12:57752278-57752278
35	CDK4	NM_000075.4(CDK4):c.414C>G (p.His138Gln)	SNV	Uncertain significance	880834		GRCh37: 12:58144814-58144814 GRCh38: 12:57751031-57751031
36	CDK4	NC_000012.12:g.57752350C>T	SNV	Uncertain significance	802869	rs1280668662	GRCh37: 12:58146133-58146133 GRCh38: 12:57752350-57752350
37	CDK4	NM_000075.4(CDK4):c.42C>T (p.Val14=)	SNV	Uncertain significance	186740	rs786203182	GRCh37: 12:58145459-58145459 GRCh38: 12:57751676-57751676
38	CDK4	NM_000075.4(CDK4):c.267A>G (p.Val89=)	SNV	Uncertain significance	309980	rs886049715	GRCh37: 12:58145077-58145077 GRCh38: 12:57751294-57751294
39	CDK4	NM_000075.4(CDK4):c.126_128AGG[2] (p.Gly48del)	Microsatellite	Uncertain significance	231912	rs770784286	GRCh37: 12:58145367-58145369 GRCh38: 12:57751584-57751586
40	CDK4	NM_000075.4(CDK4):c.632+9C>T	SNV	Uncertain significance	463475	rs1192976748	GRCh37: 12:58144430-58144430 GRCh38: 12:57750647-57750647
41	CDK4	NM_000075.4(CDK4):c.19G>A (p.Glu7Lys)	SNV	Uncertain significance	463463	rs1000052939	GRCh37: 12:58145482-58145482 GRCh38: 12:57751699-57751699
42	CDK4	NM_000075.4(CDK4):c.416G>A (p.Arg139Gln)	SNV	Uncertain significance	483289	rs763652580	GRCh37: 12:58144812-58144812 GRCh38: 12:57751029-57751029
43	CDK4	NC_000012.12:g.57752476A>G	SNV	Likely benign	802870	rs865902881	GRCh37: 12:58146259-58146259 GRCh38: 12:57752476-57752476
44	CDK4	NM_000075.4(CDK4):c.523-20A>T	SNV	Likely benign	802868	rs1595110299	GRCh37: 12:58144568-58144568 GRCh38: 12:57750785-57750785
45	CDK4	NM_000075.4(CDK4):c.14G>A (p.Arg5Gln)	SNV	Likely benign	419527	rs1031329993	GRCh37: 12:58145487-58145487 GRCh38: 12:57751704-57751704
46	CDK4 , TSPAN31	NM_000075.4(CDK4):c.660C>T (p.Ala220=)	SNV	Likely benign	387376	rs773490152	GRCh37: 12:58143260-58143260 GRCh38: 12:57749477-57749477
47	CDK4	NM_000075.4(CDK4):c.549C>T (p.Pro183=)	SNV	Likely benign	186813	rs778696237	GRCh37: 12:58144522-58144522 GRCh38: 12:57750739-57750739
48	CDK4	NM_000075.4(CDK4):c.306A>G (p.Thr102=)	SNV	Likely benign	184409	rs201202764	GRCh37: 12:58145038-58145038 GRCh38: 12:57751255-57751255
49	CDK4	NM_000075.4(CDK4):c.355-12C>T	SNV	Likely benign	392783	rs1004281478	GRCh37: 12:58144885-58144885 GRCh38: 12:57751102-57751102
50	CDK4	NM_000075.4(CDK4):c.504G>A (p.Gln168=)	SNV	Likely benign	463470	rs770086242	GRCh37: 12:58144724-58144724 GRCh38: 12:57750941-57750941

UniProtKB/Swiss-Prot genetic disease variations for Melanoma, Cutaneous Malignant 3:

⁷²

#	Symbol	AA change	Variation ID	SNP ID
1	CDK4	p.Arg24Cys	VAR_006200	rs11547328
2	CDK4	p.Arg24His	VAR_006201	rs104894340
3	CDK4	p.Asn41Ser	VAR_021152	rs144890720

Cosmic variations for Melanoma, Cutaneous Malignant 3:

⁹ (show all 46)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM97107326	NRAS	skin,ear,malignant melanoma,NS	c.181C>A	p.Q61K	1:114713909-114713909	6
2	COSM93665204	NF1	skin,ear,malignant melanoma,NS	c.3652C>T	p.Q1218*	17:31233157-31233157	6
3	COSM93539965	NF1	skin,ear,malignant melanoma,NS	c.3097C>T	p.Q1033*	17:31230366-31230366	6
4	COSM93692305	NF1	skin,ear,malignant melanoma,NS	c.3097C>T	p.Q1033*	17:31230366-31230366	6
5	COSM93519256	NF1	skin,ear,malignant melanoma,NS	c.3652C>T	p.Q1218*	17:31233157-31233157	6
6	COSM88321369	KIT	skin,eye,malignant melanoma,NS	c.1459G>A	p.G487S	4:54725969-54725969	6
7	COSM99100400	GRIN2A	skin,ear,malignant melanoma,NS	c.3217G>A	p.E1073K	16:9764327-9764327	6
8	COSM99100596	GRIN2A	skin,ear,malignant melanoma,NS	c.1959G>A	p.M653I	16:9829471-9829471	6
9	COSM89609735	GRIN2A	skin,ear,malignant melanoma,NS	c.1959G>A	p.M653I	16:9829471-9829471	6
10	COSM135206415	GRIN2A	skin,ear,malignant melanoma,NS	c.3217G>A	p.E1073K	16:9764327-9764327	6
11	COSM135217389	GRIN2A	skin,ear,malignant melanoma,NS	c.3773-19C>T	p.?	16:9763447-9763447	6
12	COSM131440106	GRIN2A	skin,ear,malignant melanoma,NS	c.1548G>A	p.M516I	16:9829471-9829471	6
13	COSM89609531	GRIN2A	skin,ear,malignant melanoma,NS	c.3217G>A	p.E1073K	16:9764327-9764327	6
14	COSM135206628	GRIN2A	skin,ear,malignant melanoma,NS	c.1959G>A	p.M653I	16:9829471-9829471	6
15	COSM89621238	GRIN2A	skin,ear,malignant melanoma,NS	c.4097C>T	p.P1366L	16:9763447-9763447	6
16	COSM99112008	GRIN2A	skin,ear,malignant melanoma,NS	c.4097C>T	p.P1366L	16:9763447-9763447	6
17	COSM131447592	GRIN2A	skin,ear,malignant melanoma,NS	c.3362-19C>T	p.?	16:9763447-9763447	6
18	COSM131440017	GRIN2A	skin,ear,malignant melanoma,NS	c.2806G>A	p.E936K	16:9764327-9764327	6
19	COSM97223158	CNR1	skin,ear,malignant melanoma,NS	c.103+42C>T	p.?	6:88145130-88145130	6
20	COSM152018575	CNR1	skin,ear,malignant melanoma,NS	c.145C>T	p.P49S	6:88145130-88145130	6
21	COSM108059286	CNR1	skin,ear,malignant melanoma,NS	c.145C>T	p.P49S	6:88145130-88145130	6
22	COSM117327995	CNR1	skin,ear,malignant melanoma,NS	c.63-17C>T	p.?	6:88145130-88145130	6
23	COSM96983478	CNR1	skin,ear,malignant melanoma,NS	c.145C>T	p.P49S	6:88145130-88145130	6
24	COSM96990932	CNR1	skin,ear,malignant melanoma,NS	c.145C>T	p.P49S	6:88145130-88145130	6
25	COSM87493313	CHRM3	skin,ear,malignant melanoma,NS	c.1741T>A	p.F581I	1:239909192-239909192	6
26	COSM144455643	CHRM3	skin,ear,malignant melanoma,NS	c.1741T>A	p.F581I	1:239909192-239909192	6
27	COSM149414554	BRAF	skin,ear,malignant melanoma,NS	c.1910T>G	p.L637R	7:140753345-140753345	6
28	COSM150563774	BRAF	skin,ear,malignant melanoma,NS	c.1799T>A	p.V600E	7:140753336-140753336	6
29	COSM150564452	BRAF	skin,ear,malignant melanoma,NS	c.1801A>G	p.K601E	7:140753334-140753334	6
30	COSM88812698	BRAF	skin,ear,malignant melanoma,NS	c.1910T>A	p.L637Q	7:140753345-140753345	6
31	COSM118795694	BRAF	skin,ear,malignant melanoma,NS	c.1790T>A	p.L597Q	7:140753345-140753345	6
32	COSM88803061	BRAF	skin,ear,malignant melanoma,NS	c.1919T>A	p.V640E	7:140753336-140753336	6
33	COSM118813778	BRAF	skin,ear,malignant melanoma,NS	c.1790T>G	p.L597R	7:140753345-140753345	6
34	COSM88806346	BRAF	skin,ear,malignant melanoma,NS	c.1900G>A	p.D634N	7:140753355-140753355	6
35	COSM118790577	BRAF	skin,ear,malignant melanoma,NS	c.1780G>A	p.D594N	7:140753355-140753355	6
36	COSM150570620	BRAF	skin,ear,malignant melanoma,NS	c.1790T>A	p.L597Q	7:140753345-140753345	6
37	COSM150565869	BRAF	skin,ear,malignant melanoma,NS	c.1780G>A	p.D594N	7:140753355-140753355	6
38	COSM118787231	BRAF	skin,ear,malignant melanoma,NS	c.1799T>A	p.V600E	7:140753336-140753336	6
39	COSM150585368	BRAF	skin,ear,malignant melanoma,NS	c.1790T>G	p.L597R	7:140753345-140753345	6
40	COSM149385292	BRAF	skin,ear,malignant melanoma,NS	c.1919T>A	p.V640E	7:140753336-140753336	6
41	COSM149386940	BRAF	skin,ear,malignant melanoma,NS	c.1921A>G	p.K641E	7:140753334-140753334	6
42	COSM149388933	BRAF	skin,ear,malignant melanoma,NS	c.1900G>A	p.D634N	7:140753355-140753355	6
43	COSM88834639	BRAF	skin,ear,malignant melanoma,NS	c.1910T>G	p.L637R	7:140753345-140753345	6
44	COSM118788384	BRAF	skin,ear,malignant melanoma,NS	c.1801A>G	p.K601E	7:140753334-140753334	6
45	COSM149394818	BRAF	skin,ear,malignant melanoma,NS	c.1910T>A	p.L637Q	7:140753345-140753345	6
46	COSM88804430	BRAF	skin,ear,malignant melanoma,NS	c.1921A>G	p.K641E	7:140753334-140753334	6

Sources

Expression for Melanoma, Cutaneous Malignant 3

Search GEO for disease gene expression data for Melanoma, Cutaneous Malignant 3.

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Pathways for Melanoma, Cutaneous Malignant 3

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GO Terms for Melanoma, Cutaneous Malignant 3

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Sources for Melanoma, Cutaneous Malignant 3

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Melanoma, Cutaneous Malignant 3 (CMM3)

Aliases & Classifications for Melanoma, Cutaneous Malignant 3

MalaCards integrated aliases for Melanoma, Cutaneous Malignant 3:

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Summaries for Melanoma, Cutaneous Malignant 3

Related Diseases for Melanoma, Cutaneous Malignant 3

Diseases in the Melanoma, Cutaneous Malignant 1 family:

Diseases related to Melanoma, Cutaneous Malignant 3 via text searches within MalaCards or GeneCards Suite gene sharing:

Symptoms & Phenotypes for Melanoma, Cutaneous Malignant 3

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Expression for Melanoma, Cutaneous Malignant 3

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Sources for Melanoma, Cutaneous Malignant 3