MCID: MLN013
MIFTS: 38

Melanoma Metastasis

Categories: Skin diseases, Cancer diseases

Aliases & Classifications for Melanoma Metastasis

MalaCards integrated aliases for Melanoma Metastasis:

Name: Melanoma Metastasis 38

Classifications:



Summaries for Melanoma Metastasis

MalaCards based summary : Melanoma Metastasis is related to melanoma and hepatitis. An important gene associated with Melanoma Metastasis is TRPM1 (Transient Receptor Potential Cation Channel Subfamily M Member 1), and among its related pathways/superpathways are TGF-Beta Pathway and Development Angiotensin activation of ERK. The drugs Paclitaxel and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and skin, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Melanoma Metastasis

Diseases related to Melanoma Metastasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 melanoma 10.7
2 hepatitis 10.0
3 melanoma, uveal 9.9
4 skin melanoma 9.9
5 ocular melanoma 9.9
6 aging 9.7
7 choroiditis 9.7
8 amelanotic melanoma 9.7
9 endotheliitis 9.7
10 colorectal cancer 9.6
11 thrombosis 9.6
12 microphthalmia 9.6
13 obstructive jaundice 9.6
14 panniculitis 9.6
15 giant cell tumor 9.6
16 cervicitis 9.6
17 pancreatitis 9.6
18 pseudosarcomatous fibromatosis 9.6
19 fasciitis 9.6
20 intraocular melanoma 9.6
21 tièche-jadassohn nevus 9.6
22 paraneoplastic syndromes 9.6
23 lung sarcoma 8.7 CREB1 IL18 NME1

Graphical network of the top 20 diseases related to Melanoma Metastasis:



Diseases related to Melanoma Metastasis

Symptoms & Phenotypes for Melanoma Metastasis

MGI Mouse Phenotypes related to Melanoma Metastasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 CREB1 CXCR4 F2R IL18 ITGA5 MCAM
2 growth/size/body region MP:0005378 9.76 CREB1 CXCR4 F2R IL18 ITGA5 KISS1
3 mortality/aging MP:0010768 9.56 CREB1 CXCR4 F2R IL18 ITGA5 KISS1
4 nervous system MP:0003631 9.28 CREB1 CXCR4 F2R IL18 ITGA5 KISS1

Drugs & Therapeutics for Melanoma Metastasis

Drugs for Melanoma Metastasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Imiquimod Approved, Investigational Phase 1, Phase 2 99011-02-6 57469
3
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
4
Fludarabine Approved Phase 2 21679-14-1, 75607-67-9 30751
5
nivolumab Approved Phase 2,Phase 1,Not Applicable 946414-94-4
6
Pembrolizumab Approved Phase 2,Not Applicable 1374853-91-4
7
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
8
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
9
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
10
Dabrafenib Approved, Investigational Phase 1, Phase 2,Not Applicable 1195765-45-7 44462760 44516822
11
Trametinib Approved Phase 1, Phase 2 871700-17-3 11707110
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
13
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
14
Nicotinamide Approved, Investigational, Nutraceutical Phase 2 98-92-0 936
15 Albumin-Bound Paclitaxel Phase 2
16 Antimitotic Agents Phase 2
17 Antineoplastic Agents, Phytogenic Phase 2
18 Adjuvants, Immunologic Phase 1, Phase 2
19 Interferon Inducers Phase 1, Phase 2
20 Interferon-alpha Phase 1, Phase 2
21 interferons Phase 1, Phase 2
22 Vaccines Phase 1, Phase 2,Phase 2
23 Interleukin-2 Phase 2,Not Applicable
24 Antibodies Phase 2,Phase 1
25 Antibodies, Monoclonal Phase 2,Phase 1
26 Immunoglobulins Phase 2,Phase 1
27 Analgesics Phase 2,Not Applicable
28 Analgesics, Non-Narcotic Phase 2,Not Applicable
29 Anti-HIV Agents Phase 2
30 Anti-Infective Agents Phase 2,Phase 1
31 Anti-Retroviral Agents Phase 2
32 Antiviral Agents Phase 2,Phase 1
33 Peripheral Nervous System Agents Phase 2,Not Applicable
34 Micronutrients Phase 2
35 Nicotinic Acids Phase 2
36 Protein Kinase Inhibitors Phase 2,Phase 1,Not Applicable
37 Trace Elements Phase 2
38 Vitamin B Complex Phase 2
39 Vitamins Phase 2
40 Pharmaceutical Solutions Phase 1, Phase 2
41 Folate Nutraceutical Phase 2
42 Vitamin B3 Nutraceutical Phase 2
43 Vitamin B9 Nutraceutical Phase 2
44 Tyrphostins Phase 1
45
Melphalan Approved 148-82-3 4053 460612
46 Liver Extracts
47 Alkylating Agents
48 Antineoplastic Agents, Alkylating
49 Immunosuppressive Agents
50 Cola Nutraceutical Not Applicable

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 Pilot Study Investigating the Metabolic Activity and Transcriptional Profiling in Vivo in Tumor Biopsies in Melanoma Patients During Treatment With Pazopanib Alone and in Combination With Paclitaxel Unknown status NCT01666418 Phase 2 Pazopanib/Paclitaxel
2 Peptide Vaccination Associated With Tumoral Immunomodulation in Patients With Advanced Metastatic Melanoma Unknown status NCT01191034 Phase 1, Phase 2 Vaccine MAGE-3.A1 peptide, or the NA17.A2 peptide + IL-2, IFN-α and GMCSF, Imiquimod.
3 Treatment of Metastatic Melanoma With Tumor Infiltrating Lymphocytes and IL-2 Following Lympho-depleting Chemotherapy Unknown status NCT00604136 Phase 2
4 Immunotherapy Study for Patients With Stage IV Melanoma Unknown status NCT02054520 Phase 2 HyperAcute®-Melanoma (HAM) Immunotherapy;Ipilimumab;Pembrolizumab;Nivolumab
5 Intralesional Treatment With Interleukin-2 (Proleukin) in Soft Tissue Melanoma Metastases Completed NCT00204581 Phase 2 Interleukin-2 (Proleukin)
6 Monocentric Pilot Study Investigating the Metabolic Activity of Melanoma in Vivo During Sorafenib and Dacarbazine Completed NCT00794235 Phase 2 Sorafenib (Nexavar), Dacarbazine (DTIC)
7 A Clinical Trial to Evaluate a Melanoma Helper Peptide Vaccine Plus Dabrafenib and Trametinib Recruiting NCT02382549 Phase 1, Phase 2 dabrafenib;Trametinib
8 A Study Using Tumor-Reactive Autologous Tumor Infiltrating Lymphocytes (TIL) in Metastatic Melanomas Terminated NCT02375984 Phase 2
9 Biomarker Correlates of Hypoxia in Metastatic Melanoma Withdrawn NCT02061007 Phase 2 Pimonidazole hydrochloride (Hypoxyprobe™-1);Optional 18F-FMISO PET scan (18F-fluoromisonidazole)
10 Combination Therapy of Topical Imiquimod Plus Multipeptide Vaccination for Cutaneous Metastases of Melanoma Completed NCT01264731 Phase 1 Imiquimod
11 Intratumoral Injection Of Alpha-Gal Glycosphingolipids Completed NCT00668512 Phase 1
12 Immunotherapy of Melanoma Patients Completed NCT00112216 Phase 1
13 Safety and Efficacy Study of Vemurafenib and High-dose Interferon Alfa-2b in Melanoma Completed NCT01943422 Phase 1 High-dose Interferon alfa-2b;Vemurafenib
14 SRS and Nivolumab in Treating Patients With Newly Diagnosed Melanoma Metastases in the Brain or Spine Recruiting NCT02716948 Phase 1
15 Trial of WP1066 in Patients With Recurrent Malignant Glioma and Brain Metastasis From Melanoma Not yet recruiting NCT01904123 Phase 1 WP1066
16 SRS (Stereotactic Radiosurgery) Plus Ipilimumab Terminated NCT01950195 Phase 1
17 miRNA Machinery in Melanoma, Melanoma Metastases and Benign Melanocytic Naevi Completed NCT01444560
18 Comparative Microarray Analysis in Primary Cutaneous Malignant Melanoma Completed NCT01482260
19 Pilot Study of Infrared Imaging of Cutaneous Melanoma Completed NCT00937690
20 Combined PET/CT Imaging for the Early Detection of Ocular Melanoma Metastasis Compared to CT Scanning Alone Completed NCT00351728
21 Videoscopic Ilioinguinal Lymphadenectomy for Melanoma Completed NCT02508909 Not Applicable
22 S9431: Studying Genes and Immune Response in Tumor Samples From Patients With Locally Advanced or Metastatic Melanoma Completed NCT00898183
23 An Analysis of the Response of Human Tumor Microvascular Endothelium to Ionizing Radiation Completed NCT00132704
24 Biomarkers for the Activity of Immune Checkpoint Inhibitor Therapy in Patients With Advanced Melanoma Recruiting NCT02673970
25 New Tumor Models in Three Dimensions and in a Human Skin Environment for Personalized Melanoma Therapy Recruiting NCT03136783 Not Applicable
26 Isolated Limb Perfusion of Melphalan for Melanoma and Sarcoma Treatment Recruiting NCT01920516 Melphalan
27 PD-L1 PET Imaging in Melanoma Patients Recruiting NCT03520634 Not Applicable
28 CNS and Extracranial Tumor Tissues, CSF, and Blood From Patients With Melanoma Brain Metastases Recruiting NCT02058953
29 IL2 Imaging in Metastatic Melanoma Recruiting NCT02922283 Not Applicable
30 [18F]Dabrafenib Molecular Imaging in Melanoma Brain Metastasis Recruiting NCT02700763 Not Applicable

Search NIH Clinical Center for Melanoma Metastasis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Melanoma Metastasis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Melanoma Metastasis:
Tumor infiltrating lymphocytes (TILs) for solid tumors
Embryonic/Adult Cultured Cells Related to Melanoma Metastasis:
Tumor infiltrating lymphocytes PMIDs: 24329789 19342963 23904171 21498393 22996367 19304471 22555974 15800326 23650429 21325070 24218514 8170938 12242449

Genetic Tests for Melanoma Metastasis

Anatomical Context for Melanoma Metastasis

MalaCards organs/tissues related to Melanoma Metastasis:

41
Brain, Liver, Skin, Lung, Lymph Node, Endothelial, T Cells

Publications for Melanoma Metastasis

Articles related to Melanoma Metastasis:

(show top 50) (show all 180)
# Title Authors Year
1
Genome-Wide Screen for MicroRNAs Reveals a Role for miR-203 in Melanoma Metastasis. ( 29104160 )
2018
2
Computed tomography-guided minimally invasive selective approach of an isolated retroperitoneal melanoma metastasis. ( 29154516 )
2018
3
Inhibition of p38 and ERK1/2 pathways by Sparstolonin B suppresses inflammation-induced melanoma metastasis. ( 29276966 )
2018
4
Comparative genomics reveals that loss of lunatic fringe (LFNG) promotes melanoma metastasis. ( 29193607 )
2018
5
Genome-Wide Analysis of Uveal Melanoma Metastasis-Associated LncRNAs and Their Functional Network. ( 29240458 )
2018
6
Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and I^1-integrin activation. ( 29712618 )
2018
7
Conjunctival Melanoma Metastasis to the Contralateral Orbit. ( 29894459 )
2018
8
PHLPP1 mediates melanoma metastasis suppression through repressing AKT2 activation. ( 29391600 )
2018
9
Prolonged survival of a patient with brain melanoma metastasis treated with BRAF and MEK inhibitors combination therapy. ( 29747484 )
2018
10
A Targeted Proteomic Approach for Heat Shock Proteins Reveals DNAJB4 as a Suppressor for Melanoma Metastasis. ( 29722524 )
2018
11
Gold nanoparticles as tracking devices to shed light on the role of caveolin-1 in early stages of melanoma metastasis. ( 29972676 )
2018
12
Get with the Program! Stemness and Reprogramming in Melanoma Metastasis. ( 29273143 )
2018
13
Functional expression of olfactory receptors in human primary melanoma and melanoma metastasis. ( 28191688 )
2017
14
A Systems Biology Approach Identifies FUT8 as a Driver of Melanoma Metastasis. ( 28609658 )
2017
15
Cranial subarachnoid and subdural haemorrhage caused by spinal melanoma metastasis. ( 28283001 )
2017
16
Midkine and Melanoma Metastasis: A Malevolent Mix. ( 28787586 )
2017
17
Mass spectrometry based identification of galectin-3 interacting proteins potentially involved in lung melanoma metastasis. ( 28875213 )
2017
18
Intra-articular Melanoma Metastasis in the Ankle Joint. ( 28806255 )
2017
19
Selumetinib Inhibits Melanoma Metastasis to Mouse Liver via Suppression of EMT-targeted Genes. ( 28179307 )
2017
20
Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review. ( 28789341 )
2017
21
Codonopsis lanceolata polysaccharide CLPS inhibits melanoma metastasis via regulating integrin signaling. ( 28527988 )
2017
22
Balloon cell melanoma metastasis to the temporal lobe. ( 29323097 )
2017
23
PET Scan Misses Cutaneous Melanoma Metastasis with Significant Tumour Size and Tumour Thickness. ( 29362627 )
2017
24
Combination therapy of PKCIP and COX-2 inhibitors synergistically suppress melanoma metastasis. ( 28865485 )
2017
25
Progressive visual disturbance and enlarging prolactinoma caused by melanoma metastasis: A case report and literature review. ( 28383413 )
2017
26
Giant cell tumor mimicking melanoma metastasis: radioguided surgery of a lesion detected on PET/CT. ( 28613000 )
2017
27
The Tail and the String Sign: New Sonographic Features of Subcutaneous Melanoma Metastasis. ( 27743725 )
2017
28
Melanoma Metastasis to the Mandible-Case Report and Comprehensive Literature Review. ( 28654767 )
2017
29
Sox2 is not required for melanomagenesis, melanoma growth and melanoma metastasis in vivo. ( 28368402 )
2017
30
Inhibition of melanoma metastasis by dual-peptide PLGA NPS. ( 28547860 )
2017
31
ABCB5 promotes melanoma metastasis through enhancing NF-I_B p65 protein stability. ( 28821433 )
2017
32
Correction to: Olubajo F et al., Cranial subarachnoid and subdural haemorrhage caused by spinal melanoma metastasis. ( 28992725 )
2017
33
Efficacy of Juzentaihoto for Tumor Immunotherapy in B16 Melanoma Metastasis Model. ( 28286532 )
2017
34
PD-1/PD-L1 and VEGF-A/VEGF-C expression in lymph node microenvironment and association with melanoma metastasis and survival. ( 28984690 )
2017
35
Dietary Crocin Reverses Melanoma Metastasis. ( 29219852 )
2017
36
Role of NOX2-Derived Reactive Oxygen Species in NK Cell-Mediated Control of Murine Melanoma Metastasis. ( 28760732 )
2017
37
Endobronchial melanoma metastasis 40 years after the excision of the primary cutaneous tumor: A case report. ( 28834918 )
2017
38
Conditional Survival: An Assessment of the Prognosis of Patients at Time Points After Initial Diagnosis and Treatment of Locoregional Melanoma Metastasis. ( 28375785 )
2017
39
Association of sentinel lymph node diameter with melanoma metastasis. ( 26827186 )
2016
40
Choroid Melanoma Metastasis to Spine: A Rare Case Report. ( 26989537 )
2016
41
Genome-wide methylation sequencing of paired primary and metastatic cell lines identifies common DNA methylation changes and a role for EBF3 as a candidate epigenetic driver of melanoma metastasis. ( 28030832 )
2016
42
Corrigendum: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance. ( 27383789 )
2016
43
Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis. ( 27259249 )
2016
44
Notch1-WISP-1 axis determines the regulatory role of mesenchymal stem cell-derived stromal fibroblasts in melanoma metastasis. ( 27813493 )
2016
45
Imaging of ocular melanoma metastasis. ( 27168029 )
2016
46
Knockout of MDA-9/Syntenin (SDCBP) expression in the microenvironment dampens tumor-supporting inflammation and inhibits melanoma metastasis. ( 27341128 )
2016
47
Androgen receptor promotes melanoma metastasis via altering the miRNA-539-3p/USP13/MITF/AXL signals. ( 27869170 )
2016
48
C-myc overexpression drives melanoma metastasis by promoting vasculogenic mimicry via c-myc/snail/Bax signaling. ( 27543492 )
2016
49
Antibody Therapy Targeting CD47 and CD271 Effectively Suppresses Melanoma Metastasis in Patient-Derived Xenografts. ( 27477289 )
2016
50
A PGC1I+-mediated transcriptional axis suppresses melanoma metastasis. ( 27580028 )
2016

Variations for Melanoma Metastasis

Expression for Melanoma Metastasis

Search GEO for disease gene expression data for Melanoma Metastasis.

Pathways for Melanoma Metastasis

GO Terms for Melanoma Metastasis

Biological processes related to Melanoma Metastasis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.65 IL18 ITGA5 MCAM
2 positive regulation of cell migration GO:0030335 9.54 F2R ITGA5 MCAM
3 positive regulation of smooth muscle cell proliferation GO:0048661 9.51 IL18 PTAFR
4 lactation GO:0007595 9.49 CREB1 NME1
5 positive regulation of vasoconstriction GO:0045907 9.46 F2R PTAFR
6 mammary gland development GO:0030879 9.43 CREB1 NME1
7 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482 9.4 F2R KISS1
8 positive regulation of cytosolic calcium ion concentration GO:0007204 9.33 CXCR4 F2R KISS1
9 lipopolysaccharide-mediated signaling pathway GO:0031663 9.32 IL18 PTAFR
10 positive regulation of smooth muscle contraction GO:0045987 9.26 F2R PTAFR
11 inflammatory response GO:0006954 9.26 CXCR4 F2R IL18 PTAFR
12 cellular response to fatty acid GO:0071398 8.8 CREB1 NME1 PTAFR

Sources for Melanoma Metastasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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