MCID: MLN013
MIFTS: 40

Melanoma Metastasis

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Melanoma Metastasis

MalaCards integrated aliases for Melanoma Metastasis:

Name: Melanoma Metastasis 38

Classifications:



Summaries for Melanoma Metastasis

MalaCards based summary : Melanoma Metastasis is related to melanoma and melanoma, uveal. An important gene associated with Melanoma Metastasis is TRPM1 (Transient Receptor Potential Cation Channel Subfamily M Member 1), and among its related pathways/superpathways are PI3K-Akt signaling pathway and HIF1Alpha Pathway. The drugs Imiquimod and Nivolumab have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and lung, and related phenotypes are cardiovascular system and cellular

Related Diseases for Melanoma Metastasis

Diseases related to Melanoma Metastasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
# Related Disease Score Top Affiliating Genes
1 melanoma 11.0
2 melanoma, uveal 10.2
3 skin melanoma 10.2
4 intraocular melanoma 10.1
5 ocular melanoma 10.1
6 drug-induced lupus erythematosus 10.0 MCAM VEGFA
7 bleeding disorder, platelet-type, 11 9.9 F2R ITGA2
8 retinal vein occlusion 9.8 ITGA2 VEGFA
9 obstructive jaundice 9.8
10 amelanotic melanoma 9.8
11 hypoxia 9.8
12 opiate dependence 9.8 CREB1 VEGFA
13 breast cancer 9.7
14 colorectal cancer 9.7
15 intussusception 9.7
16 aging 9.7
17 sleep apnea 9.7
18 thrombosis 9.7
19 microphthalmia 9.7
20 spinal cord melanoma 9.7
21 panniculitis 9.7
22 breast fibroadenoma 9.7
23 giant cell tumor 9.7
24 pseudosarcomatous fibromatosis 9.7
25 fasciitis 9.7
26 tièche-jadassohn nevus 9.7
27 nevus of ota 9.7

Graphical network of the top 20 diseases related to Melanoma Metastasis:



Diseases related to Melanoma Metastasis

Symptoms & Phenotypes for Melanoma Metastasis

MGI Mouse Phenotypes related to Melanoma Metastasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 ADAM10 CREB1 F2R IL18 MCAM PHIP
2 cellular MP:0005384 9.8 ADAM10 CREB1 F2R IL18 ITGA2 PHIP
3 homeostasis/metabolism MP:0005376 9.61 ADAM10 CREB1 F2R IL18 ITGA2 KISS1
4 digestive/alimentary MP:0005381 9.55 ADAM10 F2R IL18 KISS1 VEGFA
5 nervous system MP:0003631 9.23 ADAM10 CREB1 F2R IL18 KISS1 PTAFR

Drugs & Therapeutics for Melanoma Metastasis

Drugs for Melanoma Metastasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 1, Phase 2 99011-02-6 57469
2
Nivolumab Approved Phase 2,Phase 1,Not Applicable 946414-94-4
3
Pembrolizumab Approved Phase 2,Not Applicable 1374853-91-4
4
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
5
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
6
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
7
Nicotinamide Approved, Investigational Phase 2 98-92-0 936
8
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
9
Trametinib Approved Phase 1, Phase 2 871700-17-3 11707110
10
Dabrafenib Approved, Investigational Phase 1, Phase 2,Not Applicable 1195765-45-7 44462760 44516822
11
Fludarabine Approved Phase 2 75607-67-9, 21679-14-1 30751
12
Cyclophosphamide Approved, Investigational Phase 2 6055-19-2, 50-18-0 2907
13
Melphalan Approved Phase 1, Phase 2 148-82-3 4053 460612
14
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
15
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
16 interferons Phase 1, Phase 2
17 Interferon Inducers Phase 1, Phase 2
18 Vaccines Phase 1, Phase 2,Phase 2
19 Adjuvants, Immunologic Phase 1, Phase 2
20 Interferon-alpha Phase 1, Phase 2
21 Immunologic Factors Phase 1, Phase 2,Phase 2
22 Antibodies Phase 2,Phase 1
23 Antibodies, Monoclonal Phase 2,Phase 1
24 Immunoglobulins Phase 2,Phase 1
25 Peripheral Nervous System Agents Phase 2,Not Applicable
26 Antiviral Agents Phase 2,Phase 1
27 Anti-Infective Agents Phase 2,Phase 1
28 Analgesics Phase 2,Not Applicable
29 Anti-Retroviral Agents Phase 2
30 Interleukin-2 Phase 2,Not Applicable
31 Analgesics, Non-Narcotic Phase 2,Not Applicable
32 Anti-HIV Agents Phase 2
33 Vitamin B3 Phase 2
34 Folate Phase 2
35 Vitamin B9 Phase 2
36 Micronutrients Phase 2
37 Vitamin B Complex Phase 2
38 Nicotinic Acids Phase 2
39 Trace Elements Phase 2
40 Vitamins Phase 2
41 Protein Kinase Inhibitors Phase 2,Phase 1,Not Applicable
42 Albumin-Bound Paclitaxel Phase 2
43 Antimitotic Agents Phase 2
44 Antineoplastic Agents, Phytogenic Phase 2
45 Pharmaceutical Solutions Phase 1, Phase 2
46 Anesthetics Phase 1, Phase 2
47
Vemurafenib Approved Phase 1 918504-65-1 23252090 42611257
48 Liver Extracts
49 Immunosuppressive Agents
50 Antineoplastic Agents, Alkylating

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 Peptide Vaccination Associated With Tumoral Immunomodulation in Patients With Advanced Metastatic Melanoma Unknown status NCT01191034 Phase 1, Phase 2 Vaccine MAGE-3.A1 peptide, or the NA17.A2 peptide + IL-2, IFN-α and GMCSF, Imiquimod.
2 Immunotherapy Study for Patients With Stage IV Melanoma Unknown status NCT02054520 Phase 2 HyperAcute®-Melanoma (HAM) Immunotherapy;Ipilimumab;Pembrolizumab;Nivolumab
3 Intralesional Treatment With Interleukin-2 (Proleukin) in Soft Tissue Melanoma Metastases Completed NCT00204581 Phase 2 Interleukin-2 (Proleukin)
4 Monocentric Pilot Study Investigating the Metabolic Activity of Melanoma in Vivo During Sorafenib and Dacarbazine Completed NCT00794235 Phase 2 Sorafenib (Nexavar), Dacarbazine (DTIC)
5 Pilot Study Investigating the Metabolic Activity and Transcriptional Profiling in Vivo in Tumor Biopsies in Melanoma Patients During Treatment With Pazopanib Alone and in Combination With Paclitaxel Completed NCT01666418 Phase 2 Pazopanib/Paclitaxel
6 A Clinical Trial to Evaluate a Melanoma Helper Peptide Vaccine Plus Dabrafenib and Trametinib Recruiting NCT02382549 Phase 1, Phase 2 dabrafenib;Trametinib
7 Treatment of Metastatic Melanoma With Tumor Infiltrating Lymphocytes and IL-2 Following Lympho-depleting Chemotherapy Recruiting NCT00604136 Phase 2
8 Intralesional Sclerosant for in Transit and Cutaneous Melanoma Metastases Not yet recruiting NCT03754140 Phase 2 Polidocanol Injection
9 Evaluating the Effect of Nivolumab for Patients With In-transit Metastases Treated With Isolated Limb Perfusion Not yet recruiting NCT03685890 Phase 1, Phase 2 Nivolumab
10 A Study Using Tumor-Reactive Autologous Tumor Infiltrating Lymphocytes (TIL) in Metastatic Melanomas Terminated NCT02375984 Phase 2
11 Biomarker Correlates of Hypoxia in Metastatic Melanoma Withdrawn NCT02061007 Phase 2 Pimonidazole hydrochloride (Hypoxyprobe™-1);Optional 18F-FMISO PET scan (18F-fluoromisonidazole)
12 Combination Therapy of Topical Imiquimod Plus Multipeptide Vaccination for Cutaneous Metastases of Melanoma Completed NCT01264731 Phase 1 Imiquimod
13 Intratumoral Injection Of Alpha-Gal Glycosphingolipids Completed NCT00668512 Phase 1
14 Immunotherapy of Melanoma Patients Completed NCT00112216 Phase 1
15 Safety and Efficacy Study of Vemurafenib and High-dose Interferon Alfa-2b in Melanoma Completed NCT01943422 Phase 1 High-dose Interferon alfa-2b;Vemurafenib
16 SRS and Nivolumab in Treating Patients With Newly Diagnosed Melanoma Metastases in the Brain or Spine Recruiting NCT02716948 Phase 1
17 SRS (Stereotactic Radiosurgery) Plus Ipilimumab Terminated NCT01950195 Phase 1
18 miRNA Machinery in Melanoma, Melanoma Metastases and Benign Melanocytic Naevi Completed NCT01444560
19 Comparative Microarray Analysis in Primary Cutaneous Malignant Melanoma Completed NCT01482260
20 Pilot Study of Infrared Imaging of Cutaneous Melanoma Completed NCT00937690
21 Combined PET/CT Imaging for the Early Detection of Ocular Melanoma Metastasis Compared to CT Scanning Alone Completed NCT00351728
22 Videoscopic Ilioinguinal Lymphadenectomy for Melanoma Completed NCT02508909 Not Applicable
23 S9431: Studying Genes and Immune Response in Tumor Samples From Patients With Locally Advanced or Metastatic Melanoma Completed NCT00898183
24 An Analysis of the Response of Human Tumor Microvascular Endothelium to Ionizing Radiation Completed NCT00132704
25 Biomarkers for the Activity of Immune Checkpoint Inhibitor Therapy in Patients With Advanced Melanoma Recruiting NCT02673970
26 New Tumor Models in Three Dimensions and in a Human Skin Environment for Personalized Melanoma Therapy Recruiting NCT03136783 Not Applicable
27 Isolated Limb Perfusion of Melphalan for Melanoma and Sarcoma Treatment Recruiting NCT01920516 Melphalan
28 PD-L1 PET Imaging in Melanoma Patients Recruiting NCT03520634 Not Applicable
29 CNS and Extracranial Tumor Tissues, CSF, and Blood From Patients With Melanoma Brain Metastases Recruiting NCT02058953
30 IL2 Imaging in Metastatic Melanoma Recruiting NCT02922283 Not Applicable
31 [18F]Dabrafenib Molecular Imaging in Melanoma Brain Metastasis Recruiting NCT02700763 Not Applicable

Search NIH Clinical Center for Melanoma Metastasis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Melanoma Metastasis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Melanoma Metastasis:
Tumor infiltrating lymphocytes (TILs) for solid tumors
Embryonic/Adult Cultured Cells Related to Melanoma Metastasis:
Tumor infiltrating lymphocytes PMIDs: 24329789 19342963 23904171 21498393 22996367 19304471 22555974 15800326 23650429 21325070 24218514 8170938 12242449

Genetic Tests for Melanoma Metastasis

Anatomical Context for Melanoma Metastasis

MalaCards organs/tissues related to Melanoma Metastasis:

41
Skin, Lymph Node, Lung, Brain, T Cells, Liver, Spinal Cord

Publications for Melanoma Metastasis

Articles related to Melanoma Metastasis:

(show top 50) (show all 359)
# Title Authors Year
1
Genome-Wide Screen for MicroRNAs Reveals a Role for miR-203 in Melanoma Metastasis. ( 29104160 )
2018
2
Computed tomography-guided minimally invasive selective approach of an isolated retroperitoneal melanoma metastasis. ( 29154516 )
2018
3
Inhibition of p38 and ERK1/2 pathways by Sparstolonin B suppresses inflammation-induced melanoma metastasis. ( 29276966 )
2018
4
Comparative genomics reveals that loss of lunatic fringe (LFNG) promotes melanoma metastasis. ( 29193607 )
2018
5
Genome-Wide Analysis of Uveal Melanoma Metastasis-Associated LncRNAs and Their Functional Network. ( 29240458 )
2018
6
Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and I^1-integrin activation. ( 29712618 )
2018
7
Conjunctival Melanoma Metastasis to the Contralateral Orbit. ( 29894459 )
2018
8
PHLPP1 mediates melanoma metastasis suppression through repressing AKT2 activation. ( 29391600 )
2018
9
Prolonged survival of a patient with brain melanoma metastasis treated with BRAF and MEK inhibitors combination therapy. ( 29747484 )
2018
10
A Targeted Proteomic Approach for Heat Shock Proteins Reveals DNAJB4 as a Suppressor for Melanoma Metastasis. ( 29722524 )
2018
11
Gold nanoparticles as tracking devices to shed light on the role of caveolin-1 in early stages of melanoma metastasis. ( 29972676 )
2018
12
Get with the Program! Stemness and Reprogramming in Melanoma Metastasis. ( 29273143 )
2018
13
Remodeling of the collagen matrix in aging skin promotes melanoma metastasis and affects immune cell motility. ( 30279173 )
2018
14
Management of sentinel node melanoma metastasis in the popliteal fossa. ( 30554596 )
2018
15
An 11-gene-based prognostic signature for uveal melanoma metastasis based on gene expression and DNA methylation profile. ( 30556166 )
2018
16
STAM-binding protein regulates melanoma metastasis through SLUG stabilization. ( 30454887 )
2018
17
Nevus of Ota associated with a primary uveal melanoma and intracranial melanoma metastasis. ( 30372724 )
2018
18
Positive margins after surgical excision of locoregional cutaneous melanoma metastasis and their impact on patient outcome. ( 30378546 )
2018
19
Early Diagnosis of Skin Melanoma Metastasis by Means of Dermoscopy and Confocal Microscopy. ( 30383118 )
2018
20
Morphological classification of melanoma metastasis with reflectance confocal microscopy. ( 30394598 )
2018
21
Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis. ( 30279172 )
2018
22
NFAT5 promotes in vivo development of murine melanoma metastasis. ( 30293684 )
2018
23
Cysteine Proteases from V. cundinamarcensis (C. candamarcensis) Inhibit Melanoma Metastasis and Modulate Expression of Proteins Related to Proliferation, Migration and Differentiation. ( 30241282 )
2018
24
The Role of PPARβ/δ in Melanoma Metastasis. ( 30241392 )
2018
25
EnABLing Cathepsin-Driven Melanoma Metastasis. ( 30250913 )
2018
26
An omega-3 polyunsaturated fatty acid derivative, 18-HEPE, protects against CXCR4-associated melanoma metastasis. ( 30184109 )
2018
27
Comparative profiling of analog targets: a case study on resveratrol for mouse melanoma metastasis suppression. ( 30026862 )
2018
28
A Targeted Quantitative Proteomic Approach Assesses the Reprogramming of Small GTPases during Melanoma Metastasis. ( 30072397 )
2018
29
CEACAM1 promotes melanoma metastasis and is involved in the regulation of the EMT associated gene network in melanoma cells. ( 30089785 )
2018
30
5-Aminolevulinic acid fluorescence-guided surgery for spinal cord melanoma metastasis: a technical note. ( 30091052 )
2018
31
Methylation marks melanoma metastasis. ( 30141547 )
2018
32
Functional expression of olfactory receptors in human primary melanoma and melanoma metastasis. ( 28191688 )
2017
33
A Systems Biology Approach Identifies FUT8 as a Driver of Melanoma Metastasis. ( 28609658 )
2017
34
Cranial subarachnoid and subdural haemorrhage caused by spinal melanoma metastasis. ( 28283001 )
2017
35
Midkine and Melanoma Metastasis: A Malevolent Mix. ( 28787586 )
2017
36
Mass spectrometry based identification of galectin-3 interacting proteins potentially involved in lung melanoma metastasis. ( 28875213 )
2017
37
Intra-articular Melanoma Metastasis in the Ankle Joint. ( 28806255 )
2017
38
Selumetinib Inhibits Melanoma Metastasis to Mouse Liver via Suppression of EMT-targeted Genes. ( 28179307 )
2017
39
Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review. ( 28789341 )
2017
40
Codonopsis lanceolata polysaccharide CLPS inhibits melanoma metastasis via regulating integrin signaling. ( 28527988 )
2017
41
Balloon cell melanoma metastasis to the temporal lobe. ( 29323097 )
2017
42
PET Scan Misses Cutaneous Melanoma Metastasis with Significant Tumour Size and Tumour Thickness. ( 29362627 )
2017
43
Combination therapy of PKCIP and COX-2 inhibitors synergistically suppress melanoma metastasis. ( 28865485 )
2017
44
Progressive visual disturbance and enlarging prolactinoma caused by melanoma metastasis: A case report and literature review. ( 28383413 )
2017
45
Giant cell tumor mimicking melanoma metastasis: radioguided surgery of a lesion detected on PET/CT. ( 28613000 )
2017
46
The Tail and the String Sign: New Sonographic Features of Subcutaneous Melanoma Metastasis. ( 27743725 )
2017
47
Melanoma Metastasis to the Mandible-Case Report and Comprehensive Literature Review. ( 28654767 )
2017
48
Sox2 is not required for melanomagenesis, melanoma growth and melanoma metastasis in vivo. ( 28368402 )
2017
49
Inhibition of melanoma metastasis by dual-peptide PLGA NPS. ( 28547860 )
2017
50
ABCB5 promotes melanoma metastasis through enhancing NF-I_B p65 protein stability. ( 28821433 )
2017

Variations for Melanoma Metastasis

Expression for Melanoma Metastasis

Search GEO for disease gene expression data for Melanoma Metastasis.

Pathways for Melanoma Metastasis

GO Terms for Melanoma Metastasis

Cellular components related to Melanoma Metastasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.92 ADAM10 F2R ITGA2 VEGFA

Biological processes related to Melanoma Metastasis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.76 ADAM10 F2R PHIP VEGFA
2 cytokine-mediated signaling pathway GO:0019221 9.74 IL18 PTAFR VEGFA
3 angiogenesis GO:0001525 9.71 IL18 MCAM VEGFA
4 positive regulation of cell adhesion GO:0045785 9.56 ITGA2 VEGFA
5 lactation GO:0007595 9.55 CREB1 VEGFA
6 response to hypoxia GO:0001666 9.54 CREB1 ITGA2 VEGFA
7 lipopolysaccharide-mediated signaling pathway GO:0031663 9.52 IL18 PTAFR
8 mammary gland development GO:0030879 9.51 CREB1 ITGA2
9 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482 9.49 F2R KISS1
10 positive regulation of vasoconstriction GO:0045907 9.48 F2R PTAFR
11 positive regulation of cell migration GO:0030335 9.46 ADAM10 F2R MCAM VEGFA
12 cellular response to fatty acid GO:0071398 9.43 CREB1 PTAFR
13 positive regulation of collagen biosynthetic process GO:0032967 9.4 F2R ITGA2
14 positive regulation of leukocyte migration GO:0002687 9.32 ITGA2 VEGFA
15 positive regulation of positive chemotaxis GO:0050927 9.26 ITGA2 VEGFA
16 positive regulation of smooth muscle cell proliferation GO:0048661 9.13 IL18 ITGA2 PTAFR
17 positive regulation of smooth muscle contraction GO:0045987 8.8 F2R ITGA2 PTAFR

Sources for Melanoma Metastasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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