MCID: MLN064
MIFTS: 24

Melanoma of Soft Tissue

Categories: Cancer diseases, Muscle diseases, Rare diseases, Skin diseases

Aliases & Classifications for Melanoma of Soft Tissue

MalaCards integrated aliases for Melanoma of Soft Tissue:

Name: Melanoma of Soft Tissue 58
Clear Cell Sarcoma of the Tendons and Aponeuroses 58

Classifications:



External Ids:

UMLS via Orphanet 71 C0206651
Orphanet 58 ORPHA97338

Summaries for Melanoma of Soft Tissue

MalaCards based summary : Melanoma of Soft Tissue, also known as clear cell sarcoma of the tendons and aponeuroses, is related to ewing sarcoma and clear cell sarcoma. An important gene associated with Melanoma of Soft Tissue is ATF1 (Activating Transcription Factor 1), and among its related pathways/superpathways are Development Angiotensin activation of ERK and Myometrial Relaxation and Contraction Pathways. The drugs Melphalan and Dactinomycin have been mentioned in the context of this disorder. Affiliated tissues include lymph node.

Wikipedia : 73 Clear cell sarcoma is a rare form of cancer called a sarcoma. It is known to occur mainly in the soft... more...

Related Diseases for Melanoma of Soft Tissue

Diseases related to Melanoma of Soft Tissue via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 ewing sarcoma 30.1 EWSR1 ATF1
2 clear cell sarcoma 29.3 EWSR1 CREB1 ATF1
3 sarcoma 10.4
4 spindle cell sarcoma 10.4
5 biphasic synovial sarcoma 10.4
6 epithelioid sarcoma 10.4
7 rare soft tissue tumor 10.4
8 melanoma 10.1
9 sarcoma, synovial 10.0
10 connective tissue benign neoplasm 10.0
11 fibrosarcoma 10.0
12 liposarcoma 10.0
13 soft tissue sarcoma 10.0
14 posttransplant acute limbic encephalitis 10.0
15 rare tumor 10.0
16 sarcomatosis 9.8 EWSR1 ATF1
17 chondrosarcoma, extraskeletal myxoid 9.8 EWSR1 ATF1
18 myxoid liposarcoma 9.8 EWSR1 ATF1
19 neurofibromatosis, type i 9.6 EWSR1 CREB1
20 peripheral nervous system disease 9.5 EWSR1 CREB1
21 fibrous histiocytoma 9.4 EWSR1 CREB1 ATF1

Graphical network of the top 20 diseases related to Melanoma of Soft Tissue:



Diseases related to Melanoma of Soft Tissue

Symptoms & Phenotypes for Melanoma of Soft Tissue

Drugs & Therapeutics for Melanoma of Soft Tissue

Drugs for Melanoma of Soft Tissue (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melphalan Approved Phase 2 148-82-3 4053 460612
2
Dactinomycin Approved, Investigational Phase 2 50-76-0 2019 457193
3 Antibiotics, Antitubercular Phase 2
4 Anti-Infective Agents Phase 2
5 Alkylating Agents Phase 2
6 Immunosuppressive Agents Phase 2
7 Immunologic Factors Phase 2
8 Anti-Bacterial Agents Phase 2
9
Dacarbazine Approved, Investigational Phase 1 4342-03-4 5351166 2942
10
Bortezomib Approved, Investigational Phase 1 179324-69-7 93860 387447

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Trial of Isolated Limb Infusion With Melphalan and Dactinomycin for Regional Melanoma and Soft Tissue Sarcoma of the Extremity Completed NCT00004250 Phase 2 isolated limb perfusion;melphalan
2 Intratumoral Injection of IP-001 Following Thermal Ablation in Patients With Advanced Solid Tumors. A Multicenter Phase Ib/IIa Trial With Expansion Cohorts in Melanoma and Soft Tissue Sarcoma Patients. Recruiting NCT03993678 Phase 1, Phase 2 IP-001
3 Phase I Trial of Dacarbazine and Bortezomib in Melanoma and Soft Tissue Sarcoma Completed NCT00580320 Phase 1 Dacarbazine and bortezomib

Search NIH Clinical Center for Melanoma of Soft Tissue

Genetic Tests for Melanoma of Soft Tissue

Anatomical Context for Melanoma of Soft Tissue

MalaCards organs/tissues related to Melanoma of Soft Tissue:

40
Lymph Node

Publications for Melanoma of Soft Tissue

Articles related to Melanoma of Soft Tissue:

(show all 25)
# Title Authors PMID Year
1
Malignant gastrointestinal neuroectodermal tumor with BRAF mutation and a history of malignant melanoma: A case report. 61
33335731 2021
2
Intra-Extracranial Primary Clear Cell Sarcoma: The First Report and Review of the Literature. 61
30880192 2019
3
Presumed choroidal metastasis secondary to clear cell sarcoma of the right knee. 61
23053771 2013
4
[Primary clear cell sarcoma of the ileum]. 61
18185472 2007
5
Is clear cell sarcoma a malignant form of psammomatous melanotic schwannoma? Case report. 61
17341045 2006
6
Sentinel node biopsy for clear cell sarcoma. 61
16672185 2006
7
Sentinel lymph node biopsy reveals a positive popliteal node in clear cell sarcoma. 61
16334118 2005
8
Lessons to be learned: a case study approach. Malignant melanoma of soft tissue. 61
15712852 2005
9
Clear cell sarcoma (malignant melanoma of soft parts) and sentinel lymph node biopsy. 61
15701594 2005
10
Clear cell sarcoma in the era of sentinel lymph node mapping. 61
15334639 2004
11
Clear cell sarcoma: an institutional review. 61
15098780 2004
12
Malignant melanoma of the buttock presenting as a Buruli ulcer. 61
12126073 2002
13
Clear cell sarcoma of tendons and aponeuroses in pediatric patients: a report from the Italian and German Soft Tissue Sarcoma Cooperative Group. 61
12115360 2002
14
Clear cell sarcoma: the Roswell Park experience. 61
11344475 2001
15
Febrile arthritis as the first manifestation of clear cell sarcoma of the tendons and aponeuroses. 61
9809366 1998
16
Cytodiagnosis of malignant melanoma of soft tissue: report of a case with diagnosis by intraoperative cytology. 61
9755678 1998
17
[Clear-cell sarcoma of the tendons and aponeuroses. Immunohistochemical study of 2 cases]. 61
8532406 1995
18
[Clear-cell sarcoma of the tendons and aponeuroses]. 61
8531447 1995
19
Malignant melanoma of soft tissue. A report of three cases with diagnosis by fine needle aspiration cytology. 61
8147218 1994
20
[Clear cell sarcoma of the tendons and aponeuroses]. 61
8053772 1993
21
Clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft tissue). A case report. 61
2149419 1990
22
A monoclonal antibody specific for cells of the melanocyte lineage. 61
3276209 1988
23
Ultrastructural similarities and differences of synovial sarcoma, epithelioid sarcoma, and clear cell sarcoma of the tendons and aponeuroses. 61
6087526 1984
24
[Clear cell sarcoma of the tendons and aponeuroses. A study of 2 cases using electron microscopy]. 61
6261392 1981
25
[Clear-cell sarcoma of the tendons and aponeuroses (apropos of 6 cases)]. 61
5727104 1968

Variations for Melanoma of Soft Tissue

Expression for Melanoma of Soft Tissue

Search GEO for disease gene expression data for Melanoma of Soft Tissue.

Pathways for Melanoma of Soft Tissue

Pathways related to Melanoma of Soft Tissue according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.3 CREB1 ATF1
2
Show member pathways
12.01 CREB1 ATF1
3 11.85 CREB1 ATF1
4
Show member pathways
11.81 CREB1 ATF1
5 11.76 EWSR1 ATF1
6 11.67 CREB1 ATF1
7 11.62 CREB1 ATF1
8 11.41 CREB1 ATF1
9
Show member pathways
11.37 CREB1 ATF1
10
Show member pathways
11.31 CREB1 ATF1
11 11.24 CREB1 ATF1
12 10.8 CREB1 ATF1
13 10.5 CREB1 ATF1
14 9.9 CREB1 ATF1

GO Terms for Melanoma of Soft Tissue

Cellular components related to Melanoma of Soft Tissue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.96 CREB1 ATF1
2 ATF4-CREB1 transcription factor complex GO:1990589 8.62 CREB1 ATF1

Biological processes related to Melanoma of Soft Tissue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 8.8 EWSR1 CREB1 ATF1

Molecular functions related to Melanoma of Soft Tissue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 8.96 CREB1 ATF1
2 identical protein binding GO:0042802 8.8 EWSR1 CREB1 ATF1

Sources for Melanoma of Soft Tissue

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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