MCID: MLN002
MIFTS: 26

Melanomatosis

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Melanomatosis

MalaCards integrated aliases for Melanomatosis:

Name: Melanomatosis 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:7206
NCIt 50 C9499
UMLS 70 C1334691

Summaries for Melanomatosis

MalaCards based summary : Melanomatosis is related to meningeal melanomatosis and skin melanoma. An important gene associated with Melanomatosis is NRAS (NRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Gap junction and GnRH secretion. Affiliated tissues include skin, spinal cord and bone marrow, and related phenotypes are integument and pigmentation

Related Diseases for Melanomatosis

Diseases related to Melanomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 meningeal melanomatosis 31.9 NRAS MLANA GNAQ
2 skin melanoma 29.2 TYR NRAS MLANA GNAQ
3 meningeal melanoma 29.1 TYR NRAS MLANA GTPBP4 GNAQ
4 diffuse leptomeningeal melanocytosis 11.2
5 melanosis, neurocutaneous 10.2
6 hydrocephalus 10.2
7 melanoma 10.2
8 malignant anus melanoma 10.1 NRAS MLANA
9 hypomelanosis of ito 10.1 NRAS GNAQ
10 sensory organ benign neoplasm 10.1 NRAS MLANA
11 meningeal melanocytoma 10.1 MLANA GNAQ
12 mongolian spot 10.1 MLANA GNAQ
13 mucosal melanoma 10.1 NRAS GNAQ
14 ciliary body cancer 10.0 TYR MLANA
15 melanoacanthoma 10.0 TYR MLANA
16 halo nevi 10.0 TYR MLANA
17 sarcomatoid transitional cell carcinoma 10.0 TYR MLANA
18 spinal cord melanoma 10.0 TYR MLANA
19 diffuse meningeal melanocytosis 10.0 TYR MLANA
20 melanocytic nevus syndrome, congenital 10.0 TYR NRAS
21 epithelioid cell melanoma 10.0 TYR MLANA
22 nevus, epidermal 10.0 NRAS GNAQ
23 orofacial cleft 8 10.0 TYR MLANA
24 meningitis 10.0
25 headache 10.0
26 ocular melanoma 10.0 NRAS GNAQ
27 amelanotic melanoma 10.0 TYR MLANA
28 keratosis, seborrheic 10.0 TYR MLANA
29 mature teratoma of the ovary 10.0 PVR MLANA
30 ovarian cystic teratoma 10.0 PVR MLANA
31 angiomyolipoma 9.9 TYR MLANA
32 clear cell sarcoma 9.9 TYR MLANA
33 conjunctival nevus 9.9 NRAS MLANA GNAQ
34 malignant dermis tumor 9.9 NRAS MLANA GNAQ
35 malignant skin fibrous histiocytoma 9.9 NRAS MLANA GNAQ
36 vulvar melanoma 9.9 NRAS MLANA GNAQ
37 malignant conjunctival melanoma 9.9 NRAS MLANA GNAQ
38 spitzoid melanoma 9.9 NRAS MLANA GNAQ
39 conjunctival cancer 9.9 NRAS MLANA GNAQ
40 skin benign neoplasm 9.9 TYR MLANA
41 large congenital melanocytic nevus 9.9 NRAS MLANA GNAQ
42 uveal disease 9.9 TYR NRAS GNAQ
43 neurofibroma 9.8 TYR MLANA
44 hair whorl 9.8
45 sarcoidosis 1 9.8
46 periodontitis, chronic 9.8
47 aspiration pneumonia 9.8
48 viral meningitis 9.8
49 amnestic disorder 9.8
50 rabies 9.8

Graphical network of the top 20 diseases related to Melanomatosis:



Diseases related to Melanomatosis

Symptoms & Phenotypes for Melanomatosis

MGI Mouse Phenotypes related to Melanomatosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.35 GNAQ GTPBP4 MLANA NRAS TYR
2 pigmentation MP:0001186 9.02 GNAQ GTPBP4 MLANA NRAS TYR

Drugs & Therapeutics for Melanomatosis

Search Clinical Trials , NIH Clinical Center for Melanomatosis

Genetic Tests for Melanomatosis

Anatomical Context for Melanomatosis

MalaCards organs/tissues related to Melanomatosis:

40
Skin, Spinal Cord, Bone Marrow, Skeletal Muscle, Pineal, Ovary, Prostate

Publications for Melanomatosis

Articles related to Melanomatosis:

(show top 50) (show all 97)
# Title Authors PMID Year
1
[Melanocytic Tumors]. 61
33762462 2021
2
Primary leptomeningeal melanomatosis manifesting as new-onset refractory status epilepticus a case report - Where do you get the best cerebrospinal fluid sample? 61
33578258 2021
3
Diagnosis of meningeal melanomatosis in a dog using magnetic resonance imaging and cerebrospinal fluid findings. 61
33250483 2021
4
Letter to the Editor Regarding "Brain Atrophy Associated with Primary Diffuse Meningeal Melanomatosis". 61
33348519 2021
5
Primary leptomeningeal melanomatosis successfully treated with PD-1 inhibitor pembrolizumab: A case report. 61
33327228 2020
6
An Uncommon Case of Primary Leptomeningeal Melanoma in a 66-Year-Old White Caucasian Male. 61
33163297 2020
7
Surgical excision of a malignant metastatic melanoma located in a skeletal muscle of the lateral thorax of a horse. 61
32991055 2020
8
[A case of meningeal melanomatosis diagnosed by immunostaining of cerebrospinal fluid]. 61
32641630 2020
9
Brain Atrophy Associated with Primary Diffuse Meningeal Melanomatosis. 61
32004738 2020
10
Pediatric primary diffuse leptomeningeal melanomatosis: Case report and review of the literature. 61
32080099 2020
11
Primary diffuse meningeal melanomatosis - a rare form of meningeal melanoma: case report. 61
31690266 2019
12
Treating TB human neuroectodermal cell line with retinoic acid induces the appearance of neuron-like voltage-gated ionic currents. 61
30660613 2019
13
Primary Diffuse Leptomeningeal Melanomatosis: Case Report and Review of the Literature. 61
30496931 2019
14
Primary Diffuse Leptomeningeal Melanomatosis of Spine: 18F-FDG PET Findings. 61
30516687 2019
15
NRASQ61K mutated diffuse leptomeningeal melanomatosis in an adult patient with a brief review of the so-called "forme fruste" of neurocutaneous melanosis. 61
30145692 2018
16
Primary diffuse leptomeningeal melanomatosis: Description and recommendations. 61
29422361 2018
17
Two cases of primary leptomeningeal melanomatosis mimicking subacute meningitis. 61
28627959 2018
18
Diagnostic Difficulties in Primary Pauci-Melanotic Leptomeningeal Melanomatosis. 61
30231251 2018
19
Primary central nervous system malignant melanoma with leptomeningeal melanomatosis: a case report and review of the literature. 61
28986666 2018
20
[A case of leptomeningeal melanomatosis with acute paraplegia and multiple cranial nerve palsies]. 61
29187689 2017
21
Meningeal melanomatosis following discontinuation of dabrafenib: implications for the maintenance of long-term complete remission. 61
28723725 2017
22
CSF cytology diagnosis of NRAS-mutated primary leptomeningeal melanomatosis with neurocutaneous melanosis. 61
27696542 2017
23
[Melanocytoma and meningeal melanocytosis, similar but different lesions]. 61
28126183 2017
24
Supratentorial intermediate grade meningeal melanocytoma with intratumoral bleed in the background of neurocutaneous melanosis: Report of an unusual case and review of literature. 61
28413547 2017
25
Brain 18F-choline PET/CT in primary diffuse leptomeningeal melanomatosis. 61
27085711 2016
26
Primary Amelanotic Leptomeningeal Melanomatosis in a Child: A Rare but Severe Disease. 61
27319310 2016
27
NRAS(Q61K) mutated primary leptomeningeal melanoma in a child: case presentation and discussion on clinical and diagnostic implications. 61
27439913 2016
28
Primary Intracranial Leptomeningeal Melanomatosis. 61
26819692 2015
29
Leptomeningeal melanomatosis associated with neurocutaneous melanosis: an autopsy case report. 61
25521302 2015
30
Meningeal melanomatosis: a challenge for timely diagnosis. 61
25648721 2015
31
Rare and challenging extra-axial brain lesions: CT and MRI findings with clinico-radiological differential diagnosis and pathological correlation. 61
25010368 2014
32
Primary melanocytic tumors of the central nervous system: Report of two cases and review of literature. 61
25371847 2014
33
[A case of leptomeningeal melanomatosis presenting with right abducens nerve palsy]. 61
25142543 2014
34
Vemurafenib for leptomeningeal melanomatosis. 61
23460716 2013
35
F-18 fluorodeoxyglucose PET/CT and post hoc PET/MRI in a case of primary meningeal melanomatosis. 61
23483049 2013
36
A patient with meningeal melanomatosis treated for periodontal disease with a bone regeneration procedure and dental implants: clinical and behavioral management to support medical compliance. 61
24772265 2013
37
[A woman with a blue discolouration of the skin]. 61
23328018 2013
38
Toxicity of hyperthermic intraperitoneal chemotherapy (HIPEC) in pediatric patients with sarcomatosis/carcinomatosis: early experience and phase 1 results. 61
22492588 2012
39
[Primary amelanotic meningeal melanomatosis]. 61
22450762 2012
40
Unusual cases: melanomatosis and nephroblastomatosis treated with hyperthermic intraperitoneal chemotherapy. 61
22498396 2012
41
Leptomeningeal melanomatosis: stabilization of disease due to radiation, temozolomide and intrathecal liposomal cytarabine. 61
21736503 2011
42
Primary malignant meningeal melanomatosis: a clinical, radiological and pathologic case study. 61
22141290 2011
43
Primary melanocytic tumors of the central nervous system: a neuroradiological and clinicopathological study of five cases and brief review of literature. 61
21743173 2011
44
Primary melanocytic neoplasms of the central nervous system. 61
20558070 2010
45
Diffuse primary leptomeningeal melanocytosis in a patient receiving a novel cancer cell vaccine for prostate cancer. 61
22736604 2010
46
Neurological picture. Ascending paralysis from malignant leptomeningeal melanomatosis. 61
20360167 2010
47
Primary diffuse meningeal melanomatosis. 61
20220448 2010
48
Pigmented lesions of the central nervous system: radiologic-pathologic correlation. 61
19755608 2009
49
[Cerebellopontine angle meningeal melanocytoma: a benign tumor?]. 61
19688139 2009
50
Disseminated melanoma in a dog with involvement of leptomeninges and bone marrow. 61
19112120 2009

Variations for Melanomatosis

Expression for Melanomatosis

Search GEO for disease gene expression data for Melanomatosis.

Pathways for Melanomatosis

Pathways related to Melanomatosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.2 NRAS GNAQ
2 10.96 NRAS GNAQ
3 10.73 NRAS GNAQ
4 9.92 NRAS GNAQ

GO Terms for Melanomatosis

Cellular components related to Melanomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome GO:0042470 8.62 TYR MLANA

Molecular functions related to Melanomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTP binding GO:0005525 9.13 NRAS GTPBP4 GNAQ
2 GTPase activity GO:0003924 8.8 NRAS GTPBP4 GNAQ

Sources for Melanomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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