MCID: MLN002
MIFTS: 36

Melanomatosis

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Melanomatosis

MalaCards integrated aliases for Melanomatosis:

Name: Melanomatosis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7206
NCIt 50 C9499
UMLS 73 C1334691

Summaries for Melanomatosis

MalaCards based summary : Melanomatosis is related to meningeal melanomatosis and diffuse leptomeningeal melanocytosis. An important gene associated with Melanomatosis is NRAS (NRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are DAG and IP3 signaling and Circadian entrainment. Affiliated tissues include skin, brain and bone, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Melanomatosis

Diseases related to Melanomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 meningeal melanomatosis 32.5 CDKN2A CWC22 GNA11 GNAQ HRAS NRAS
2 diffuse leptomeningeal melanocytosis 11.6
3 melanosis, neurocutaneous 10.3
4 syringomyelia 10.2 CWC22 NRAS
5 phakomatosis cesioflammea 10.1 GNA11 GNAQ
6 intraocular melanoma 10.1 GNA11 GNAQ
7 melanoma 10.1
8 meningitis 10.1
9 conventional fibrosarcoma 10.1 CD68 NRAS
10 diffuse meningeal melanocytosis 10.1 CD68 CWC22
11 congenital mesoblastic nephroma 10.1 NRAS WT1
12 acral lentiginous melanoma 10.1 CDKN2A NRAS
13 uveal disease 10.0 GNA11 GNAQ
14 fallopian tube squamous cell carcinoma 10.0 CDKN2A WT1
15 lymphohistiocytoid mesothelioma 10.0 CD68 CDKN2A
16 giant congenital nevus 10.0 HRAS NRAS
17 pneumatosis cystoides intestinalis 10.0 CD68 WT1
18 bladder carcinoma in situ 10.0 CD68 CDKN2A
19 benign struma ovarii 10.0 HRAS NRAS
20 schimmelpenning-feuerstein-mims syndrome 10.0 HRAS NRAS
21 scrotal carcinoma 10.0 CD68 CDKN2A
22 ovarian melanoma 10.0 HRAS NRAS
23 conventional leiomyosarcoma 10.0 CD68 CDKN2A
24 conjunctival cancer 10.0 GNA11 GNAQ NRAS
25 sarcomatoid mesothelioma 10.0 CDKN2A WT1
26 mucosal melanoma 10.0 GNA11 GNAQ NRAS
27 marcus gunn phenomenon 10.0 HRAS NRAS
28 breast giant fibroadenoma 10.0 CDKN2A WT1
29 malignant struma ovarii 10.0 HRAS NRAS
30 ischemic fasciitis 10.0 CD68 CDKN2A
31 fetal adenoma 10.0 HRAS NRAS
32 myelodysplastic myeloproliferative cancer 10.0 HRAS NRAS
33 melanocytic nevus syndrome, congenital 10.0 HRAS NRAS
34 rabies 10.0
35 patulous eustachian tube 10.0
36 periodontal disease 10.0
37 skin melanoma 10.0
38 acneiform dermatitis 10.0 HRAS NRAS
39 vulvar melanoma 10.0 HRAS NRAS
40 peritoneal mesothelioma 10.0 CDKN2A WT1
41 pleural cancer 10.0 CDKN2A WT1
42 malignant skin fibrous histiocytoma 10.0 HRAS NRAS
43 liver angiosarcoma 10.0 HRAS NRAS
44 malignant dermis tumor 10.0 HRAS NRAS
45 adult fibrosarcoma 9.9 HRAS WT1
46 gallbladder adenoma 9.9 CDKN2A HRAS
47 spitz nevus 9.9 CDKN2A HRAS
48 ocular cancer 9.9 CDKN2A GNA11 GNAQ
49 nasal cavity adenocarcinoma 9.9 CDKN2A HRAS
50 nevus, epidermal 9.9 HRAS NRAS

Graphical network of the top 20 diseases related to Melanomatosis:



Diseases related to Melanomatosis

Symptoms & Phenotypes for Melanomatosis

GenomeRNAi Phenotypes related to Melanomatosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.4 HRAS
2 Decreased viability GR00221-A-1 9.4 CDKN2A HRAS NRAS
3 Decreased viability GR00221-A-2 9.4 HRAS
4 Decreased viability GR00221-A-3 9.4 CDKN2A HRAS NRAS
5 Decreased viability GR00221-A-4 9.4 CDKN2A
6 Decreased viability GR00402-S-2 9.4 CDKN2A HRAS NRAS

MGI Mouse Phenotypes related to Melanomatosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.93 CDKN2A GNA11 GNAQ HRAS NRAS WT1
2 endocrine/exocrine gland MP:0005379 9.91 CDKN2A GNA11 GNAQ HRAS NRAS WT1
3 hematopoietic system MP:0005397 9.88 CD68 CDKN2A GNA11 GNAQ NRAS WT1
4 immune system MP:0005387 9.85 CD68 CDKN2A GNA11 GNAQ NRAS WT1
5 integument MP:0010771 9.72 CDKN2A GNA11 GNAQ HRAS NRAS
6 no phenotypic analysis MP:0003012 9.65 CD68 CDKN2A HRAS NRAS WT1
7 pigmentation MP:0001186 9.46 CDKN2A GNA11 GNAQ NRAS
8 respiratory system MP:0005388 9.35 CDKN2A GNA11 GNAQ HRAS WT1
9 skeleton MP:0005390 9.1 CD68 CDKN2A GNA11 GNAQ HRAS NRAS

Drugs & Therapeutics for Melanomatosis

Search Clinical Trials , NIH Clinical Center for Melanomatosis

Genetic Tests for Melanomatosis

Anatomical Context for Melanomatosis

MalaCards organs/tissues related to Melanomatosis:

41
Skin, Brain, Bone, Lung, Liver, Ovary, Myeloid

Publications for Melanomatosis

Articles related to Melanomatosis:

(show all 49)
# Title Authors Year
1
Primary diffuse leptomeningeal melanomatosis: Description and recommendations. ( 29422361 )
2018
2
Primary central nervous system malignant melanoma with leptomeningeal melanomatosis: a case report and review of the literature. ( 28986666 )
2018
3
Primary Diffuse Leptomeningeal Melanomatosis of Spine: 18F-FDG PET Findings. ( 30516687 )
2018
4
NRASQ61K mutated diffuse leptomeningeal melanomatosis in an adult patient with a brief review of the so-called "forme fruste" of neurocutaneous melanosis. ( 30145692 )
2018
5
Diagnostic Difficulties in Primary Pauci-Melanotic Leptomeningeal Melanomatosis. ( 30231251 )
2018
6
Primary Diffuse Leptomeningeal Melanomatosis: Case Report and Review of the Literature. ( 30496931 )
2018
7
Meningeal melanomatosis following discontinuation of dabrafenib: implications for the maintenance of long-term complete remission. ( 28723725 )
2017
8
Two cases of primary leptomeningeal melanomatosis mimicking subacute meningitis. ( 28627959 )
2017
9
CSF cytology diagnosis of NRAS-mutated primary leptomeningeal melanomatosis with neurocutaneous melanosis. ( 27696542 )
2016
10
Brain 18F-choline PET/CT in primary diffuse leptomeningeal melanomatosis. ( 27085711 )
2016
11
Primary Amelanotic Leptomeningeal Melanomatosis in a Child: A Rare but Severe Disease. ( 27319310 )
2016
12
Meningeal melanomatosis: a challenge for timely diagnosis. ( 25648721 )
2015
13
Primary Intracranial Leptomeningeal Melanomatosis. ( 26819692 )
2015
14
Leptomeningeal melanomatosis associated with neurocutaneous melanosis: an autopsy case report. ( 25521302 )
2015
15
A case of leptomeningeal melanomatosis presenting with right abducens nerve palsy. ( 25142543 )
2014
16
F-18 fluorodeoxyglucose PET/CT and post hoc PET/MRI in a case of primary meningeal melanomatosis. ( 23483049 )
2013
17
Vemurafenib for leptomeningeal melanomatosis. ( 23460716 )
2013
18
A patient with meningeal melanomatosis treated for periodontal disease with a bone regeneration procedure and dental implants: clinical and behavioral management to support medical compliance. ( 24772265 )
2013
19
Unusual cases: melanomatosis and nephroblastomatosis treated with hyperthermic intraperitoneal chemotherapy. ( 22498396 )
2012
20
Leptomeningeal melanomatosis: stabilization of disease due to radiation, temozolomide and intrathecal liposomal cytarabine. ( 21736503 )
2011
21
Primary malignant meningeal melanomatosis: a clinical, radiological and pathologic case study. ( 22141290 )
2011
22
Neurological picture. Ascending paralysis from malignant leptomeningeal melanomatosis. ( 20360167 )
2010
23
Primary diffuse meningeal melanomatosis. ( 20220448 )
2010
24
Case 134: primary leptomeningeal melanomatosis. ( 18487543 )
2008
25
Prognostic factors and outcomes in patients with leptomeningeal melanomatosis. ( 18708343 )
2008
26
Excision as treatment of dermal melanomatosis in horses: 11 cases (1994-2000). ( 15239480 )
2004
27
Cognitive decline in an elderly hospitalized patient with primary leptomeningeal melanomatosis. ( 15586607 )
2004
28
Extensive metastatic leptomeningeal melanomatosis as the first clinical sign of a cutaneous melanoma: morphological correlations between magnetic resonance imaging and autopsy findings. A case report. ( 12827619 )
2003
29
Neurocutaneous melanomatosis with a rapidly deteriorating course. ( 12591651 )
2003
30
Primary diffuse meningeal melanomatosis: radiologic-pathologic correlation. ( 12533338 )
2003
31
Primary leptomeningeal melanomatosis: early leptomeningeal enhancement on MRI. ( 11912478 )
2001
32
Chemotherapy with hybrid liposomes for melanomatosis. ( 10513636 )
1999
33
Leptomeningeal melanomatosis with multiple cutaneous pigmented nevi: tumor cell proliferation and malignant transformation in an autopsy case. ( 10582667 )
1999
34
Primary pineal and meningeal malignant melanomatosis. ( 18639049 )
1998
35
Diffuse leptomeningeal melanomatosis of the spinal cord: a case report. ( 8512019 )
1993
36
MR imaging of experimental meningeal melanomatosis in nude rats. ( 1460485 )
1992
37
Experimental meningeal melanomatosis. ( 2749474 )
1989
38
Disseminated melanomatosis of the central nervous system and other organs: a case report. ( 2706839 )
1989
39
Primary meningeal melanomatosis: limitations of current diagnostic techniques. ( 6619899 )
1983
40
Primary malignant melanomatosis of the meninges. Clinical course and computed tomographic findings in a young child. ( 7247791 )
1981
41
A new coagulation defect associated with a case of melanomatosis. ( 874111 )
1977
42
Primary leptomeningeal melanomatosis presenting as carcinomatous meningitis. ( 4547822 )
1974
43
Neurocutaneous melanosis and leptomeningeal melanomatosis in children. ( 5800928 )
1969
44
Primary malignant melanomatosis of leptomeninges. ( 5912499 )
1966
45
GENERALISED MELANOMATOSIS. ( 14177739 )
1964
46
Melanomatosis involving the heart. ( 13637009 )
1959
47
Neurological findings in a case of melanomatosis. ( 13214491 )
1954
48
Note on the experimental use of rabies vaccine for melanomatosis. ( 14770525 )
1950
49
Primary melanomatosis of the leptomeninx. ( 14784904 )
1950

Variations for Melanomatosis

Expression for Melanomatosis

Search GEO for disease gene expression data for Melanomatosis.

Pathways for Melanomatosis

Pathways related to Melanomatosis according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 GNA11 GNAQ HRAS NRAS
2
Show member pathways
12.84 GNA11 GNAQ HRAS NRAS
3
Show member pathways
12.84 CDKN2A GNA11 HRAS NRAS
4
Show member pathways
12.83 GNA11 GNAQ HRAS NRAS
5
Show member pathways
12.78 GNA11 GNAQ HRAS NRAS
6
Show member pathways
12.74 CDKN2A GNA11 GNAQ HRAS NRAS
7
Show member pathways
12.73 GNA11 GNAQ HRAS NRAS
8
Show member pathways
12.52 GNA11 GNAQ HRAS NRAS
9 12.52 CDKN2A GNA11 GNAQ HRAS NRAS
10
Show member pathways
12.43 GNA11 GNAQ HRAS NRAS
11 12.35 CDKN2A HRAS NRAS
12 12.27 CDKN2A HRAS NRAS
13
Show member pathways
12.16 GNA11 GNAQ HRAS
14 12.12 CDKN2A HRAS NRAS
15
Show member pathways
12.03 GNA11 GNAQ HRAS NRAS
16
Show member pathways
12.02 GNAQ HRAS NRAS
17 12 CDKN2A HRAS NRAS
18 11.92 GNAQ HRAS NRAS
19
Show member pathways
11.86 GNA11 GNAQ HRAS
20
Show member pathways
11.84 GNA11 GNAQ HRAS
21 11.82 GNAQ HRAS NRAS
22 11.79 CDKN2A HRAS NRAS
23 11.78 GNAQ HRAS NRAS
24
Show member pathways
11.77 GNA11 GNAQ HRAS NRAS
25
Show member pathways
11.76 CDKN2A GNA11 GNAQ HRAS NRAS
26 11.75 GNAQ HRAS NRAS
27 11.73 CDKN2A HRAS NRAS
28 11.52 CDKN2A HRAS NRAS
29 11.49 GNA11 GNAQ HRAS NRAS
30 11.42 GNA11 GNAQ HRAS
31 11.41 GNA11 GNAQ
32 11.4 GNA11 GNAQ HRAS NRAS
33 11.39 HRAS NRAS
34 11.32 HRAS NRAS
35 11.29 GNA11 GNAQ
36 11.25 GNA11 HRAS NRAS
37 11.23 GNA11 GNAQ
38 11.21 GNA11 GNAQ
39 11.21 HRAS NRAS
40 11.14 HRAS NRAS
41 11.14 HRAS NRAS
42
Show member pathways
11.12 HRAS NRAS
43
Show member pathways
11.06 HRAS NRAS
44 11 HRAS NRAS
45 10.98 HRAS NRAS
46 10.97 GNA11 GNAQ HRAS NRAS
47
Show member pathways
10.82 GNA11 GNAQ
48 10.8 GNAQ HRAS NRAS
49 10.71 HRAS NRAS
50 10.7 GNA11 GNAQ HRAS NRAS

GO Terms for Melanomatosis

Cellular components related to Melanomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosomal membrane GO:0005765 9.13 CD68 GNA11 GNAQ
2 heterotrimeric G-protein complex GO:0005834 8.62 GNA11 GNAQ

Biological processes related to Melanomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular senescence GO:0090398 9.37 CDKN2A HRAS
2 action potential GO:0001508 9.32 GNA11 GNAQ
3 G protein-coupled acetylcholine receptor signaling pathway GO:0007213 9.26 GNA11 GNAQ
4 phototransduction, visible light GO:0007603 9.16 GNA11 GNAQ
5 entrainment of circadian clock GO:0009649 8.96 GNA11 GNAQ
6 Ras protein signal transduction GO:0007265 8.8 CDKN2A HRAS NRAS

Molecular functions related to Melanomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTP binding GO:0005525 9.46 GNA11 GNAQ HRAS NRAS
2 G-protein beta/gamma-subunit complex binding GO:0031683 9.32 GNA11 GNAQ
3 guanyl nucleotide binding GO:0019001 9.26 GNA11 GNAQ
4 GTPase activity GO:0003924 9.26 GNA11 GNAQ HRAS NRAS
5 type 2A serotonin receptor binding GO:0031826 8.62 GNA11 GNAQ

Sources for Melanomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....