MCID: MLN002
MIFTS: 35

Melanomatosis

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Melanomatosis

MalaCards integrated aliases for Melanomatosis:

Name: Melanomatosis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7206
NCIt 50 C9499
UMLS 73 C1334691

Summaries for Melanomatosis

MalaCards based summary : Melanomatosis is related to meningeal melanomatosis and skin melanoma. An important gene associated with Melanomatosis is NRAS (NRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are DAG and IP3 signaling and Circadian entrainment. Affiliated tissues include pineal, heart and spinal cord, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Melanomatosis

Diseases related to Melanomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 meningeal melanomatosis 30.1 CDKN2A CWC22 GNA11 GNAQ HRAS NRAS
2 skin melanoma 27.3 CDKN2A GNA11 GNAQ HRAS NRAS
3 diffuse leptomeningeal melanocytosis 11.1
4 syringomyelia 10.5 CWC22 NRAS
5 phakomatosis cesioflammea 10.5 GNA11 GNAQ
6 intraocular melanoma 10.4 GNA11 GNAQ
7 meningitis 10.4
8 conventional fibrosarcoma 10.4 CD68 NRAS
9 congenital mesoblastic nephroma 10.3 NRAS WT1
10 acral lentiginous melanoma 10.3 CDKN2A NRAS
11 fallopian tube squamous cell carcinoma 10.1 CDKN2A WT1
12 pneumatosis cystoides intestinalis 10.1 CD68 WT1
13 giant congenital nevus 10.1 HRAS NRAS
14 lymphohistiocytoid mesothelioma 10.1 CD68 CDKN2A
15 bladder carcinoma in situ 10.1 CD68 CDKN2A
16 conventional leiomyosarcoma 10.1 CD68 CDKN2A
17 benign struma ovarii 10.1 HRAS NRAS
18 schimmelpenning-feuerstein-mims syndrome 10.1 HRAS NRAS
19 melanosis, neurocutaneous 10.1
20 ovarian melanoma 10.1 HRAS NRAS
21 conjunctival cancer 10.1 GNA11 GNAQ NRAS
22 scrotal carcinoma 10.1 CD68 CDKN2A
23 mucosal melanoma 10.1 GNA11 GNAQ NRAS
24 marcus gunn phenomenon 10.1 HRAS NRAS
25 sarcomatoid mesothelioma 10.1 CDKN2A WT1
26 malignant struma ovarii 10.0 HRAS NRAS
27 ischemic fasciitis 10.0 CD68 CDKN2A
28 breast giant fibroadenoma 10.0 CDKN2A WT1
29 myelodysplastic myeloproliferative cancer 10.0 HRAS NRAS
30 melanoma 10.0
31 nevus, epidermal 10.0 HRAS NRAS
32 melanocytic nevus syndrome, congenital 10.0 HRAS NRAS
33 vulvar melanoma 10.0 HRAS NRAS
34 acneiform dermatitis 10.0 HRAS NRAS
35 pleural cancer 10.0 CDKN2A WT1
36 malignant skin fibrous histiocytoma 9.9 HRAS NRAS
37 peritoneal mesothelioma 9.9 CDKN2A WT1
38 liver angiosarcoma 9.9 HRAS NRAS
39 malignant dermis tumor 9.9 HRAS NRAS
40 rabies 9.8
41 periodontal disease 9.8
42 periodontitis 9.8
43 adult fibrosarcoma 9.8 HRAS WT1
44 gallbladder adenoma 9.7 CDKN2A HRAS
45 spitz nevus 9.7 CDKN2A HRAS
46 hereditary wilms' tumor 9.7 HRAS WT1
47 sensory system cancer 9.7 CDKN2A GNA11 GNAQ
48 ocular cancer 9.7 CDKN2A GNA11 GNAQ
49 nasal cavity adenocarcinoma 9.7 CDKN2A HRAS
50 nervous system cancer 9.7 CDKN2A GNA11 GNAQ

Graphical network of the top 20 diseases related to Melanomatosis:



Diseases related to Melanomatosis

Symptoms & Phenotypes for Melanomatosis

GenomeRNAi Phenotypes related to Melanomatosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.4 HRAS
2 Decreased viability GR00221-A-1 9.4 CDKN2A HRAS NRAS
3 Decreased viability GR00221-A-2 9.4 HRAS
4 Decreased viability GR00221-A-3 9.4 CDKN2A HRAS NRAS
5 Decreased viability GR00221-A-4 9.4 CDKN2A
6 Decreased viability GR00402-S-2 9.4 CDKN2A HRAS NRAS

MGI Mouse Phenotypes related to Melanomatosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 GNAQ HRAS NRAS CDKN2A WT1 GNA11
2 endocrine/exocrine gland MP:0005379 9.88 GNAQ HRAS NRAS CDKN2A WT1 GNA11
3 hematopoietic system MP:0005397 9.85 GNAQ CD68 NRAS CDKN2A WT1 GNA11
4 integument MP:0010771 9.72 GNAQ HRAS NRAS CDKN2A GNA11
5 no phenotypic analysis MP:0003012 9.65 HRAS CD68 NRAS CDKN2A WT1
6 pigmentation MP:0001186 9.46 GNAQ NRAS CDKN2A GNA11
7 respiratory system MP:0005388 9.35 GNAQ HRAS CDKN2A WT1 GNA11
8 skeleton MP:0005390 9.1 GNAQ HRAS CD68 NRAS CDKN2A GNA11

Drugs & Therapeutics for Melanomatosis

Search Clinical Trials , NIH Clinical Center for Melanomatosis

Genetic Tests for Melanomatosis

Anatomical Context for Melanomatosis

MalaCards organs/tissues related to Melanomatosis:

41
Pineal, Heart, Spinal Cord, Brain, Bone

Publications for Melanomatosis

Articles related to Melanomatosis:

(show all 45)
# Title Authors Year
1
Primary diffuse leptomeningeal melanomatosis: Description and recommendations. ( 29422361 )
2018
2
Primary central nervous system malignant melanoma with leptomeningeal melanomatosis: a case report and review of the literature. ( 28986666 )
2018
3
Meningeal melanomatosis following discontinuation of dabrafenib: implications for the maintenance of long-term complete remission. ( 28723725 )
2017
4
Two cases of primary leptomeningeal melanomatosis mimicking subacute meningitis. ( 28627959 )
2017
5
CSF cytology diagnosis of NRAS-mutated primary leptomeningeal melanomatosis with neurocutaneous melanosis. ( 27696542 )
2016
6
Brain 18F-choline PET/CT in primary diffuse leptomeningeal melanomatosis. ( 27085711 )
2016
7
Primary Amelanotic Leptomeningeal Melanomatosis in a Child: A Rare but Severe Disease. ( 27319310 )
2016
8
Meningeal melanomatosis: a challenge for timely diagnosis. ( 25648721 )
2015
9
Primary Intracranial Leptomeningeal Melanomatosis. ( 26819692 )
2015
10
Leptomeningeal melanomatosis associated with neurocutaneous melanosis: an autopsy case report. ( 25521302 )
2015
11
A case of leptomeningeal melanomatosis presenting with right abducens nerve palsy. ( 25142543 )
2014
12
F-18 fluorodeoxyglucose PET/CT and post hoc PET/MRI in a case of primary meningeal melanomatosis. ( 23483049 )
2013
13
Vemurafenib for leptomeningeal melanomatosis. ( 23460716 )
2013
14
A patient with meningeal melanomatosis treated for periodontal disease with a bone regeneration procedure and dental implants: clinical and behavioral management to support medical compliance. ( 24772265 )
2013
15
Unusual cases: melanomatosis and nephroblastomatosis treated with hyperthermic intraperitoneal chemotherapy. ( 22498396 )
2012
16
Leptomeningeal melanomatosis: stabilization of disease due to radiation, temozolomide and intrathecal liposomal cytarabine. ( 21736503 )
2011
17
Primary malignant meningeal melanomatosis: a clinical, radiological and pathologic case study. ( 22141290 )
2011
18
Neurological picture. Ascending paralysis from malignant leptomeningeal melanomatosis. ( 20360167 )
2010
19
Primary diffuse meningeal melanomatosis. ( 20220448 )
2010
20
Case 134: primary leptomeningeal melanomatosis. ( 18487543 )
2008
21
Prognostic factors and outcomes in patients with leptomeningeal melanomatosis. ( 18708343 )
2008
22
Excision as treatment of dermal melanomatosis in horses: 11 cases (1994-2000). ( 15239480 )
2004
23
Cognitive decline in an elderly hospitalized patient with primary leptomeningeal melanomatosis. ( 15586607 )
2004
24
Extensive metastatic leptomeningeal melanomatosis as the first clinical sign of a cutaneous melanoma: morphological correlations between magnetic resonance imaging and autopsy findings. A case report. ( 12827619 )
2003
25
Neurocutaneous melanomatosis with a rapidly deteriorating course. ( 12591651 )
2003
26
Primary diffuse meningeal melanomatosis: radiologic-pathologic correlation. ( 12533338 )
2003
27
Primary leptomeningeal melanomatosis: early leptomeningeal enhancement on MRI. ( 11912478 )
2001
28
Chemotherapy with hybrid liposomes for melanomatosis. ( 10513636 )
1999
29
Leptomeningeal melanomatosis with multiple cutaneous pigmented nevi: tumor cell proliferation and malignant transformation in an autopsy case. ( 10582667 )
1999
30
Primary pineal and meningeal malignant melanomatosis. ( 18639049 )
1998
31
Diffuse leptomeningeal melanomatosis of the spinal cord: a case report. ( 8512019 )
1993
32
MR imaging of experimental meningeal melanomatosis in nude rats. ( 1460485 )
1992
33
Experimental meningeal melanomatosis. ( 2749474 )
1989
34
Disseminated melanomatosis of the central nervous system and other organs: a case report. ( 2706839 )
1989
35
Primary meningeal melanomatosis: limitations of current diagnostic techniques. ( 6619899 )
1983
36
Primary malignant melanomatosis of the meninges. Clinical course and computed tomographic findings in a young child. ( 7247791 )
1981
37
A new coagulation defect associated with a case of melanomatosis. ( 874111 )
1977
38
Primary leptomeningeal melanomatosis presenting as carcinomatous meningitis. ( 4547822 )
1974
39
Neurocutaneous melanosis and leptomeningeal melanomatosis in children. ( 5800928 )
1969
40
Primary malignant melanomatosis of leptomeninges. ( 5912499 )
1966
41
GENERALISED MELANOMATOSIS. ( 14177739 )
1964
42
Melanomatosis involving the heart. ( 13637009 )
1959
43
Neurological findings in a case of melanomatosis. ( 13214491 )
1954
44
Note on the experimental use of rabies vaccine for melanomatosis. ( 14770525 )
1950
45
Primary melanomatosis of the leptomeninx. ( 14784904 )
1950

Variations for Melanomatosis

Expression for Melanomatosis

Search GEO for disease gene expression data for Melanomatosis.

Pathways for Melanomatosis

Pathways related to Melanomatosis according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.9 GNA11 GNAQ HRAS NRAS
2
Show member pathways
12.83 GNA11 GNAQ HRAS NRAS
3
Show member pathways
12.82 CDKN2A GNA11 HRAS NRAS
4
Show member pathways
12.81 GNA11 GNAQ HRAS NRAS
5
Show member pathways
12.74 GNA11 GNAQ HRAS NRAS
6
Show member pathways
12.66 CDKN2A GNA11 GNAQ HRAS NRAS
7
Show member pathways
12.59 GNA11 GNAQ HRAS NRAS
8
Show member pathways
12.49 GNA11 GNAQ HRAS NRAS
9 12.44 CDKN2A GNA11 GNAQ HRAS NRAS
10
Show member pathways
12.4 GNA11 GNAQ HRAS NRAS
11 12.34 CDKN2A HRAS NRAS
12 12.26 CDKN2A HRAS NRAS
13
Show member pathways
12.14 GNA11 GNAQ HRAS
14 12.11 CDKN2A HRAS NRAS
15
Show member pathways
12.01 GNAQ HRAS NRAS
16 11.98 CDKN2A HRAS NRAS
17 11.9 GNAQ HRAS NRAS
18
Show member pathways
11.84 GNA11 GNAQ HRAS
19
Show member pathways
11.82 GNA11 GNAQ HRAS
20 11.78 GNAQ HRAS NRAS
21 11.76 CDKN2A HRAS NRAS
22 11.72 GNAQ HRAS NRAS
23 11.71 GNAQ HRAS NRAS
24 11.68 CDKN2A HRAS NRAS
25 11.47 CDKN2A HRAS NRAS
26 11.4 GNA11 GNAQ
27 11.37 HRAS NRAS
28 11.36 GNA11 GNAQ HRAS
29 11.31 HRAS NRAS
30 11.27 GNA11 GNAQ
31 11.22 GNA11 GNAQ
32 11.2 GNA11 GNAQ
33 11.2 HRAS NRAS
34 11.2 GNA11 GNAQ HRAS NRAS
35 11.13 HRAS NRAS
36 11.12 HRAS NRAS
37
Show member pathways
11.1 HRAS NRAS
38
Show member pathways
11.05 HRAS NRAS
39 10.98 HRAS NRAS
40 10.96 HRAS NRAS
41 10.87 GNA11 GNAQ HRAS NRAS
42
Show member pathways
10.8 GNA11 GNAQ
43 10.73 GNAQ HRAS NRAS
44 10.7 GNA11 GNAQ HRAS NRAS
45 10.69 HRAS NRAS

GO Terms for Melanomatosis

Cellular components related to Melanomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosomal membrane GO:0005765 9.13 CD68 GNA11 GNAQ
2 heterotrimeric G-protein complex GO:0005834 8.62 GNA11 GNAQ

Biological processes related to Melanomatosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.65 GNA11 GNAQ WT1
2 ERBB2 signaling pathway GO:0038128 9.49 HRAS NRAS
3 cellular senescence GO:0090398 9.46 CDKN2A HRAS
4 action potential GO:0001508 9.43 GNA11 GNAQ
5 G-protein coupled acetylcholine receptor signaling pathway GO:0007213 9.4 GNA11 GNAQ
6 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.37 GNA11 GNAQ
7 developmental pigmentation GO:0048066 9.32 GNA11 GNAQ
8 phototransduction, visible light GO:0007603 9.26 GNA11 GNAQ
9 entrainment of circadian clock GO:0009649 9.16 GNA11 GNAQ
10 Ras protein signal transduction GO:0007265 9.13 CDKN2A HRAS NRAS
11 regulation of melanocyte differentiation GO:0045634 8.62 GNA11 GNAQ

Molecular functions related to Melanomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTP binding GO:0005525 9.46 GNA11 GNAQ HRAS NRAS
2 G-protein beta/gamma-subunit complex binding GO:0031683 9.32 GNA11 GNAQ
3 guanyl nucleotide binding GO:0019001 9.26 GNA11 GNAQ
4 GTPase activity GO:0003924 9.26 GNA11 GNAQ HRAS NRAS
5 type 2A serotonin receptor binding GO:0031826 8.62 GNA11 GNAQ

Sources for Melanomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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