MCID: MLN002
MIFTS: 35

Melanomatosis

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Melanomatosis

MalaCards integrated aliases for Melanomatosis:

Name: Melanomatosis 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:7206
NCIt 51 C9499
UMLS 74 C1334691

Summaries for Melanomatosis

MalaCards based summary : Melanomatosis is related to meningeal melanomatosis and skin melanoma. An important gene associated with Melanomatosis is NRAS (NRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are IL-2 Pathway and DAG and IP3 signaling. Affiliated tissues include skin, brain and bone, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Melanomatosis

Diseases related to Melanomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 meningeal melanomatosis 31.9 CDKN2A CWC22 GNA11 GNAQ HRAS NRAS
2 skin melanoma 29.9 CDKN2A NRAS
3 diffuse leptomeningeal melanocytosis 11.7
4 melanosis, neurocutaneous 10.3
5 syringomyelia 10.2 CWC22 NRAS
6 melanoma 10.2
7 meningitis 10.2
8 conventional fibrosarcoma 10.2 CD68 NRAS
9 diffuse meningeal melanocytosis 10.1 CD68 CWC22
10 phakomatosis cesioflammea 10.1 GNA11 GNAQ
11 acral lentiginous melanoma 10.1 CDKN2A NRAS
12 rabies 10.0
13 patulous eustachian tube 10.0
14 periodontal disease 10.0
15 lymphohistiocytoid mesothelioma 10.0 CD68 CDKN2A
16 bladder carcinoma in situ 10.0 CD68 CDKN2A
17 scrotal carcinoma 10.0 CD68 CDKN2A
18 uveal disease 10.0 GNA11 GNAQ
19 conventional leiomyosarcoma 10.0 CD68 CDKN2A
20 giant congenital nevus 10.0 HRAS NRAS
21 benign struma ovarii 10.0 HRAS NRAS
22 schimmelpenning-feuerstein-mims syndrome 10.0 HRAS NRAS
23 ovarian melanoma 10.0 HRAS NRAS
24 ischemic fasciitis 10.0 CD68 CDKN2A
25 marcus gunn phenomenon 10.0 HRAS NRAS
26 malignant struma ovarii 10.0 HRAS NRAS
27 fetal adenoma 10.0 HRAS NRAS
28 myelodysplastic myeloproliferative cancer 10.0 HRAS NRAS
29 melanocytic nevus syndrome, congenital 10.0 HRAS NRAS
30 acneiform dermatitis 9.9 HRAS NRAS
31 vulvar melanoma 9.9 HRAS NRAS
32 malignant skin fibrous histiocytoma 9.9 HRAS NRAS
33 core binding factor acute myeloid leukemia 9.9 HRAS NRAS
34 liver angiosarcoma 9.9 HRAS NRAS
35 conjunctival cancer 9.9 GNA11 GNAQ NRAS
36 mucosal melanoma 9.9 GNA11 GNAQ NRAS
37 malignant dermis tumor 9.9 HRAS NRAS
38 gallbladder adenoma 9.9 CDKN2A HRAS
39 spitz nevus 9.9 CDKN2A HRAS
40 nevus, epidermal 9.8 HRAS NRAS
41 nasal cavity adenocarcinoma 9.8 CDKN2A HRAS
42 ocular cancer 9.8 CDKN2A GNA11 GNAQ
43 nervous system cancer 9.8 CDKN2A GNA11 GNAQ
44 skin squamous cell carcinoma 9.8 CDKN2A HRAS
45 nodular malignant melanoma 9.8 GNAQ HRAS NRAS
46 ovarian serous cystadenocarcinoma 9.7 HRAS NRAS
47 cell type benign neoplasm 9.7 CDKN2A HRAS
48 myeloma, multiple 9.6 CDKN2A HRAS NRAS
49 leukemia, chronic lymphocytic 2 9.6 HRAS NRAS
50 melanoma, uveal 9.6 CDKN2A GNA11 GNAQ NRAS

Graphical network of the top 20 diseases related to Melanomatosis:



Diseases related to Melanomatosis

Symptoms & Phenotypes for Melanomatosis

GenomeRNAi Phenotypes related to Melanomatosis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.4 HRAS
2 Decreased viability GR00221-A-1 9.4 CDKN2A HRAS NRAS
3 Decreased viability GR00221-A-2 9.4 HRAS
4 Decreased viability GR00221-A-3 9.4 CDKN2A HRAS NRAS
5 Decreased viability GR00221-A-4 9.4 CDKN2A
6 Decreased viability GR00402-S-2 9.4 CDKN2A HRAS NRAS

MGI Mouse Phenotypes related to Melanomatosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.65 CDKN2A GNA11 GNAQ HRAS NRAS
2 craniofacial MP:0005382 9.62 GNA11 GNAQ HRAS NRAS
3 integument MP:0010771 9.55 CDKN2A GNA11 GNAQ HRAS NRAS
4 pigmentation MP:0001186 9.26 CDKN2A GNA11 GNAQ NRAS
5 skeleton MP:0005390 9.1 CD68 CDKN2A GNA11 GNAQ HRAS NRAS

Drugs & Therapeutics for Melanomatosis

Search Clinical Trials , NIH Clinical Center for Melanomatosis

Genetic Tests for Melanomatosis

Anatomical Context for Melanomatosis

MalaCards organs/tissues related to Melanomatosis:

42
Skin, Brain, Bone, Heart, Spinal Cord, Pineal, Liver

Publications for Melanomatosis

Articles related to Melanomatosis:

(show all 49)
# Title Authors Year
1
Primary Diffuse Leptomeningeal Melanomatosis: Case Report and Review of the Literature. ( 30496931 )
2019
2
Two cases of primary leptomeningeal melanomatosis mimicking subacute meningitis. ( 28627959 )
2018
3
Primary central nervous system malignant melanoma with leptomeningeal melanomatosis: a case report and review of the literature. ( 28986666 )
2018
4
Primary diffuse leptomeningeal melanomatosis: Description and recommendations. ( 29422361 )
2018
5
NRASQ61K mutated diffuse leptomeningeal melanomatosis in an adult patient with a brief review of the so-called "forme fruste" of neurocutaneous melanosis. ( 30145692 )
2018
6
Diagnostic Difficulties in Primary Pauci-Melanotic Leptomeningeal Melanomatosis. ( 30231251 )
2018
7
Primary Diffuse Leptomeningeal Melanomatosis of Spine: 18F-FDG PET Findings. ( 30516687 )
2018
8
CSF cytology diagnosis of NRAS-mutated primary leptomeningeal melanomatosis with neurocutaneous melanosis. ( 27696542 )
2017
9
Meningeal melanomatosis following discontinuation of dabrafenib: implications for the maintenance of long-term complete remission. ( 28723725 )
2017
10
Brain 18F-choline PET/CT in primary diffuse leptomeningeal melanomatosis. ( 27085711 )
2016
11
Primary Amelanotic Leptomeningeal Melanomatosis in a Child: A Rare but Severe Disease. ( 27319310 )
2016
12
Leptomeningeal melanomatosis associated with neurocutaneous melanosis: an autopsy case report. ( 25521302 )
2015
13
Meningeal melanomatosis: a challenge for timely diagnosis. ( 25648721 )
2015
14
Primary Intracranial Leptomeningeal Melanomatosis. ( 26819692 )
2015
15
[A case of leptomeningeal melanomatosis presenting with right abducens nerve palsy]. ( 25142543 )
2014
16
Vemurafenib for leptomeningeal melanomatosis. ( 23460716 )
2013
17
F-18 fluorodeoxyglucose PET/CT and post hoc PET/MRI in a case of primary meningeal melanomatosis. ( 23483049 )
2013
18
A patient with meningeal melanomatosis treated for periodontal disease with a bone regeneration procedure and dental implants: clinical and behavioral management to support medical compliance. ( 24772265 )
2013
19
Unusual cases: melanomatosis and nephroblastomatosis treated with hyperthermic intraperitoneal chemotherapy. ( 22498396 )
2012
20
Leptomeningeal melanomatosis: stabilization of disease due to radiation, temozolomide and intrathecal liposomal cytarabine. ( 21736503 )
2011
21
Primary malignant meningeal melanomatosis: a clinical, radiological and pathologic case study. ( 22141290 )
2011
22
Primary diffuse meningeal melanomatosis. ( 20220448 )
2010
23
Neurological picture. Ascending paralysis from malignant leptomeningeal melanomatosis. ( 20360167 )
2010
24
Case 134: primary leptomeningeal melanomatosis. ( 18487543 )
2008
25
Prognostic factors and outcomes in patients with leptomeningeal melanomatosis. ( 18708343 )
2008
26
Excision as treatment of dermal melanomatosis in horses: 11 cases (1994-2000). ( 15239480 )
2004
27
Cognitive decline in an elderly hospitalized patient with primary leptomeningeal melanomatosis. ( 15586607 )
2004
28
Primary diffuse meningeal melanomatosis: radiologic-pathologic correlation. ( 12533338 )
2003
29
Neurocutaneous melanomatosis with a rapidly deteriorating course. ( 12591651 )
2003
30
Extensive metastatic leptomeningeal melanomatosis as the first clinical sign of a cutaneous melanoma: morphological correlations between magnetic resonance imaging and autopsy findings. A case report. ( 12827619 )
2003
31
Primary leptomeningeal melanomatosis: early leptomeningeal enhancement on MRI. ( 11912478 )
2001
32
Chemotherapy with hybrid liposomes for melanomatosis. ( 10513636 )
1999
33
Leptomeningeal melanomatosis with multiple cutaneous pigmented nevi: tumor cell proliferation and malignant transformation in an autopsy case. ( 10582667 )
1999
34
Primary pineal and meningeal malignant melanomatosis. ( 18639049 )
1998
35
Diffuse leptomeningeal melanomatosis of the spinal cord: a case report. ( 8512019 )
1993
36
MR imaging of experimental meningeal melanomatosis in nude rats. ( 1460485 )
1992
37
Disseminated melanomatosis of the central nervous system and other organs: a case report. ( 2706839 )
1989
38
Experimental meningeal melanomatosis. ( 2749474 )
1989
39
Primary meningeal melanomatosis: limitations of current diagnostic techniques. ( 6619899 )
1983
40
Primary malignant melanomatosis of the meninges. Clinical course and computed tomographic findings in a young child. ( 7247791 )
1981
41
A new coagulation defect associated with a case of melanomatosis. ( 874111 )
1977
42
Primary leptomeningeal melanomatosis presenting as carcinomatous meningitis. ( 4547822 )
1974
43
Neurocutaneous melanosis and leptomeningeal melanomatosis in children. ( 5800928 )
1969
44
Primary malignant melanomatosis of leptomeninges. ( 5912499 )
1966
45
GENERALISED MELANOMATOSIS. ( 14177739 )
1964
46
Melanomatosis involving the heart. ( 13637009 )
1959
47
Neurological findings in a case of melanomatosis. ( 13214491 )
1954
48
Note on the experimental use of rabies vaccine for melanomatosis. ( 14770525 )
1950
49
Primary melanomatosis of the leptomeninx. ( 14784904 )
1950

Variations for Melanomatosis

Expression for Melanomatosis

Search GEO for disease gene expression data for Melanomatosis.

Pathways for Melanomatosis

Pathways related to Melanomatosis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13 GNA11 GNAQ HRAS NRAS
2
Show member pathways
12.89 GNA11 GNAQ HRAS NRAS
3
Show member pathways
12.82 GNA11 GNAQ HRAS NRAS
4
Show member pathways
12.82 CDKN2A GNA11 HRAS NRAS
5
Show member pathways
12.81 GNA11 GNAQ HRAS NRAS
6
Show member pathways
12.76 GNA11 GNAQ HRAS NRAS
7
Show member pathways
12.72 GNA11 GNAQ HRAS NRAS
8
Show member pathways
12.6 CDKN2A GNA11 GNAQ HRAS NRAS
9 12.49 CDKN2A GNA11 GNAQ HRAS NRAS
10
Show member pathways
12.48 GNA11 HRAS NRAS
11
Show member pathways
12.47 GNA11 GNAQ HRAS NRAS
12
Show member pathways
12.38 GNA11 GNAQ HRAS NRAS
13 12.35 CDKN2A HRAS NRAS
14 12.2 CDKN2A HRAS NRAS
15
Show member pathways
12.14 GNA11 GNAQ HRAS
16 12.11 CDKN2A HRAS NRAS
17
Show member pathways
12.01 GNAQ HRAS NRAS
18
Show member pathways
12.01 GNA11 GNAQ HRAS NRAS
19 11.99 CDKN2A HRAS NRAS
20 11.9 GNAQ HRAS NRAS
21
Show member pathways
11.85 GNA11 GNAQ HRAS
22
Show member pathways
11.83 GNA11 GNAQ HRAS
23 11.82 GNAQ HRAS NRAS
24 11.79 CDKN2A HRAS NRAS
25 11.78 GNAQ HRAS NRAS
26 11.77 GNAQ HRAS NRAS
27 11.75 CDKN2A HRAS NRAS
28
Show member pathways
11.72 GNA11 GNAQ HRAS NRAS
29 11.53 HRAS NRAS
30 11.53 HRAS NRAS
31
Show member pathways
11.52 HRAS NRAS
32 11.52 CDKN2A HRAS NRAS
33 11.46 HRAS NRAS
34 11.45 GNA11 GNAQ HRAS NRAS
35 11.42 GNA11 GNAQ HRAS
36 11.41 GNA11 GNAQ
37 11.38 HRAS NRAS
38 11.33 HRAS NRAS
39 11.28 GNA11 GNAQ
40 11.24 GNA11 HRAS NRAS
41 11.23 GNA11 GNAQ
42 11.22 GNA11 GNAQ
43 11.22 HRAS NRAS
44 11.2 GNA11 GNAQ HRAS NRAS
45 11.15 HRAS NRAS
46 11.14 HRAS NRAS
47
Show member pathways
11.12 HRAS NRAS
48
Show member pathways
11.06 HRAS NRAS
49 10.99 HRAS NRAS
50 10.97 HRAS NRAS

GO Terms for Melanomatosis

Cellular components related to Melanomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 photoreceptor outer segment GO:0001750 9.16 GNA11 GNAQ
2 lysosomal membrane GO:0005765 9.13 CD68 GNA11 GNAQ
3 heterotrimeric G-protein complex GO:0005834 8.62 GNA11 GNAQ

Biological processes related to Melanomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.43 HRAS NRAS
2 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.4 GNA11 GNAQ
3 cellular senescence GO:0090398 9.37 CDKN2A HRAS
4 action potential GO:0001508 9.32 GNA11 GNAQ
5 G protein-coupled acetylcholine receptor signaling pathway GO:0007213 9.26 GNA11 GNAQ
6 phototransduction, visible light GO:0007603 9.16 GNA11 GNAQ
7 entrainment of circadian clock GO:0009649 8.96 GNA11 GNAQ
8 Ras protein signal transduction GO:0007265 8.8 CDKN2A HRAS NRAS

Molecular functions related to Melanomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTP binding GO:0005525 9.46 GNA11 GNAQ HRAS NRAS
2 G protein-coupled receptor binding GO:0001664 9.37 GNA11 GNAQ
3 G-protein beta/gamma-subunit complex binding GO:0031683 9.32 GNA11 GNAQ
4 guanyl nucleotide binding GO:0019001 9.26 GNA11 GNAQ
5 GTPase activity GO:0003924 9.26 GNA11 GNAQ HRAS NRAS
6 type 2A serotonin receptor binding GO:0031826 8.62 GNA11 GNAQ

Sources for Melanomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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