MCID: MLN009
MIFTS: 31

Melanotic Neurilemmoma

Categories: Cancer diseases

Aliases & Classifications for Melanotic Neurilemmoma

MalaCards integrated aliases for Melanotic Neurilemmoma:

Name: Melanotic Neurilemmoma 12 15 71
Pigmented Neurilemmoma 12
Melanotic Schwannoma 12
Pigmented Schwannoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3205
NCIt 49 C6970
SNOMED-CT 67 985004
UMLS 71 C1306247

Summaries for Melanotic Neurilemmoma

MalaCards based summary : Melanotic Neurilemmoma, also known as pigmented neurilemmoma, is related to neurilemmoma and carney complex variant. An important gene associated with Melanotic Neurilemmoma is PRKAR1A (Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and DAG and IP3 signaling. Affiliated tissues include pituitary, breast and spinal cord, and related phenotypes are Increased proliferation and integument

Related Diseases for Melanotic Neurilemmoma

Diseases related to Melanotic Neurilemmoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 neurilemmoma 31.2 SMARCB1 PRKAR1A NF2 CD34
2 carney complex variant 31.0 PRKAR2A PRKAR1A PRKACG POMC PDE11A MLANA
3 cellular schwannoma 30.3 NF2 CD34
4 plexiform schwannoma 30.1 NF2 CD34
5 spindle cell sarcoma 30.0 NF2 CD34
6 spinal meningioma 30.0 SMARCB1 NF2
7 neurilemmomatosis 29.8 SMARCB1 PRKAR1A NF2
8 conn's syndrome 29.7 PRKAR1A POMC PDE11A
9 meningioma, radiation-induced 29.6 SMARCB1 NF2
10 meningioma, familial 28.3 SMARCB1 PRKAR1A POMC NF2 MLANA CD34
11 carney complex, type 1 11.7
12 mediastinal melanocytic neurilemmoma 11.4
13 rare tumor 10.5
14 breast adenoma 10.4 PRKAR1A PDE11A
15 acth-independent cushing syndrome 10.4 PRKAR1A PDE11A
16 penis sarcoma 10.3 MLANA CD34
17 glomangiosarcoma 10.3 MLANA CD34
18 benign perivascular tumor 10.3 MLANA CD34
19 intravascular fasciitis 10.3 MLANA CD34
20 sarcomatoid squamous cell skin carcinoma 10.3 MLANA CD34
21 jejunal neoplasm 10.3 MLANA CD34
22 dermis tumor 10.3 MLANA CD34
23 vaginal endometrial stromal sarcoma 10.3 MLANA CD34
24 angiolipoma 10.3 MLANA CD34
25 malignant leptomeningeal tumor 10.3 MLANA GNAQ
26 meningeal melanoma 10.3 MLANA GNAQ
27 meningeal melanomatosis 10.3 MLANA GNAQ
28 lung meningioma 10.3 NF2 CD34
29 melanomatosis 10.3 MLANA GNAQ
30 epithelioid neurofibroma 10.3 NF2 CD34
31 parasagittal meningioma 10.3 NF2 CD34
32 cerebral convexity meningioma 10.3 NF2 CD34
33 malignant anus melanoma 10.3 MLANA GNAQ
34 infiltrating angiolipoma 10.3 MLANA CD34
35 vagina sarcoma 10.3 MLANA CD34
36 meningeal melanocytoma 10.3 MLANA GNAQ
37 glomangiomatosis 10.3 MLANA CD34
38 conjunctival nevus 10.2 MLANA GNAQ
39 uterus leiomyosarcoma 10.2 MLANA CD34
40 central nervous system melanocytic neoplasm 10.2 MLANA GNAQ
41 neurofibromatosis, type iv, of riccardi 10.2
42 melanoma 10.2
43 47,xyy 10.2
44 tièche-jadassohn nevus 10.2
45 sensory organ benign neoplasm 10.2 MLANA GNAQ
46 malignant dermis tumor 10.2 MLANA GNAQ
47 epithelioid cell melanoma 10.2 MLANA GNAQ
48 malignant skin fibrous histiocytoma 10.2 MLANA GNAQ
49 vulvar melanoma 10.2 MLANA GNAQ
50 orbital cancer 10.2 NF2 CD34

Graphical network of the top 20 diseases related to Melanotic Neurilemmoma:



Diseases related to Melanotic Neurilemmoma

Symptoms & Phenotypes for Melanotic Neurilemmoma

GenomeRNAi Phenotypes related to Melanotic Neurilemmoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

MGI Mouse Phenotypes related to Melanotic Neurilemmoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.7 CD34 GNAQ MLANA NF2 POMC PRKAR1A
2 neoplasm MP:0002006 9.35 CD34 NF2 POMC PRKAR1A SMARCB1
3 pigmentation MP:0001186 8.92 GNAQ MLANA POMC PRKAR1A

Drugs & Therapeutics for Melanotic Neurilemmoma

Search Clinical Trials , NIH Clinical Center for Melanotic Neurilemmoma

Genetic Tests for Melanotic Neurilemmoma

Anatomical Context for Melanotic Neurilemmoma

MalaCards organs/tissues related to Melanotic Neurilemmoma:

40
Pituitary, Breast, Spinal Cord, Heart, Skin, Brain, Ovary

Publications for Melanotic Neurilemmoma

Articles related to Melanotic Neurilemmoma:

(show all 15)
# Title Authors PMID Year
1
Pigmented tumors in fallow deer ( Dama dama): 11 cases. 61
28467283 2017
2
Clinicopathologic and molecular analysis of a choroidal pigmented schwannoma in the context of a PTEN hamartoma tumor syndrome. 61
22281088 2012
3
Benign Pigmented Schwannoma of the Great Omentum: Report of a Rare Case and Review of the Literature. 61
21103279 2009
4
[A rare primary tumor of the cerebellopontine angle: melanotic schwannoma, a pigmented tumor with unpredictable prognosis]. 61
18276040 2008
5
Scope of FNAC in the diagnosis of soft tissue tumors--a study from a tertiary cancer referral center in India. 61
17973999 2007
6
Plexiform pigmented schwannoma of the uvea. 61
16500216 2006
7
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors. 61
12088451 2002
8
Abnormal pigmentation of schwannoma attributed to excess production of neuromelanin-like pigment. 61
10792787 2000
9
Pigmented schwannoma of the ventral spinal cord. 61
10342906 1999
10
Coexistence of two different intraspinal tumors. Case report and review of the literature. 61
17031913 1999
11
Meningeal melanocytoma: a case report and literature review. 61
9805360 1998
12
Malignant melanoma arising in a dermoid cyst of the ovary. 61
2044057 1991
13
Malignant pigmented spinal nerve root schwannoma metastasizing in the brain and viscera. 61
2286020 1990
14
Melanotic schwannoma of the orbit. Immunohistochemical and ultrastructural study of a case and survey of the literature. 61
2206515 1990
15
Intraspinal pigmented schwannoma with malignant progression. 61
3228005 1988

Variations for Melanotic Neurilemmoma

Expression for Melanotic Neurilemmoma

Search GEO for disease gene expression data for Melanotic Neurilemmoma.

Pathways for Melanotic Neurilemmoma

Pathways related to Melanotic Neurilemmoma according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.1 PRKAR2A PRKAR1A PRKACG PDE11A GNAQ F10
2
Show member pathways
12.91 PRKAR2A PRKAR1A PRKACG POMC GNAQ
3
Show member pathways
12.71 PRKAR2A PRKAR1A PRKACG NF2
4
Show member pathways
12.7 PRKACG POMC PDE11A GNAQ
5 12.43 PRKAR1A POMC NF2 GNAQ
6
Show member pathways
12.42 PRKAR2A PRKAR1A PRKACG GNAQ
7
Show member pathways
12.37 PRKAR2A PRKAR1A PRKACG POMC
8
Show member pathways
12.19 PRKAR2A PRKAR1A PRKACG GNAQ
9
Show member pathways
12.14 PRKAR2A PRKAR1A PRKACG GNAQ
10
Show member pathways
12.12 PRKAR2A PRKAR1A PRKACG
11
Show member pathways
12.01 PRKAR2A PRKAR1A PRKACG
12 12 PRKAR2A PRKAR1A PRKACG
13 11.98 PRKAR2A PRKAR1A PRKACG
14
Show member pathways
11.97 SMARCB1 PRKAR2A PRKAR1A PRKACG
15
Show member pathways
11.72 PRKAR2A PRKAR1A PRKACG GNAQ
16 11.68 PRKAR2A PRKAR1A PRKACG
17 11.58 PRKAR2A PRKAR1A PRKACG
18 11.57 PRKAR2A PRKAR1A PRKACG GNAQ
19
Show member pathways
11.42 PRKAR2A PRKAR1A PRKACG GNAQ
20 11.39 PRKAR2A PRKAR1A PRKACG
21 11.34 PRKAR2A PRKAR1A PRKACG
22 11.3 PRKAR2A PRKAR1A PRKACG
23 11.14 PRKAR2A PRKAR1A PRKACG
24 11.05 PRKAR2A PRKAR1A PRKACG
25 10.87 PRKAR2A PRKAR1A PRKACG POMC
26 10.79 PRKAR2A PRKAR1A PRKACG
27 10.52 PRKAR2A PRKAR1A PRKACG GNAQ

GO Terms for Melanotic Neurilemmoma

Cellular components related to Melanotic Neurilemmoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane raft GO:0044853 9.26 PRKAR2A PRKAR1A
2 cAMP-dependent protein kinase complex GO:0005952 9.16 PRKAR2A PRKAR1A
3 nucleotide-activated protein kinase complex GO:0031588 8.96 PRKAR2A PRKAR1A
4 ciliary base GO:0097546 8.8 PRKAR2A PRKAR1A PRKACG

Biological processes related to Melanotic Neurilemmoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of protein kinase activity GO:0006469 9.5 PRKAR1A NF2 GNAQ
2 regulation of protein kinase activity GO:0045859 9.43 PRKAR2A PRKAR1A
3 renal water homeostasis GO:0003091 9.43 PRKAR2A PRKAR1A PRKACG
4 cGMP-mediated signaling GO:0019934 9.4 PRKAR2A PRKAR1A
5 negative regulation of cAMP-dependent protein kinase activity GO:2000480 9.37 PRKAR2A PRKAR1A
6 cellular response to glucagon stimulus GO:0071377 9.33 PRKAR2A PRKAR1A PRKACG
7 activation of protein kinase A activity GO:0034199 9.13 PRKAR2A PRKAR1A PRKACG
8 blood coagulation GO:0007596 9.02 PRKAR2A PRKAR1A PRKACG GNAQ F10

Molecular functions related to Melanotic Neurilemmoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cAMP binding GO:0030552 9.32 PRKAR2A PRKAR1A
2 protein kinase A catalytic subunit binding GO:0034236 9.26 PRKAR2A PRKAR1A
3 cAMP-dependent protein kinase inhibitor activity GO:0004862 9.16 PRKAR2A PRKAR1A
4 cAMP-dependent protein kinase regulator activity GO:0008603 8.96 PRKAR2A PRKAR1A
5 3',5'-cyclic-GMP phosphodiesterase activity GO:0047555 8.8 PRKAR2A PRKAR1A PDE11A

Sources for Melanotic Neurilemmoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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