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MCID: MLN009
MIFTS: 24

Melanotic Neurilemmoma

Categories: Cancer diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Melanotic Neurilemmoma

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MalaCards integrated aliases for Melanotic Neurilemmoma:

Name: Melanotic Neurilemmoma 12 15 72
Pigmented Neurilemmoma 12
Melanotic Schwannoma 12
Pigmented Schwannoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3205
NCIt 50 C6970
SNOMED-CT 68 985004
UMLS 72 C1306247
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Summaries for Melanotic Neurilemmoma

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MalaCards based summary : Melanotic Neurilemmoma, also known as pigmented neurilemmoma, is related to carney complex variant and neurilemmoma. An important gene associated with Melanotic Neurilemmoma is PRKAR1A (Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha), and among its related pathways/superpathways are Neuroscience and Tight junction. Affiliated tissues include brain, ovary and spinal cord.

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Related Diseases for Melanotic Neurilemmoma

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Diseases related to Melanotic Neurilemmoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 carney complex variant 32.2 PRKAR1A MYH8 F10
2 neurilemmoma 31.2 PRKAR1A NF2
3 neurilemmomatosis 29.1 PRKAR1A NF2
4 carney complex, type 1 11.7
5 mediastinal melanocytic neurilemmoma 11.4
6 rare tumor 10.5
7 neurofibromatosis, type iv, of riccardi 10.2
8 melanoma 10.2
9 tièche-jadassohn nevus 10.2
10 myositis 10.2
11 myositis ossificans 10.2
12 posttransplant acute limbic encephalitis 10.2
13 neurofibromatosis, type ii 10.0
14 lentigines 10.0
15 trigeminal neuralgia 10.0
16 yemenite deaf-blind hypopigmentation syndrome 10.0
17 carney triad 10.0
18 gastrointestinal stromal tumor 10.0
19 hydrocephalus 10.0
20 sarcoma 10.0
21 conn's syndrome 10.0
22 neutropenia 10.0
23 locked-in syndrome 10.0
24 leiomyoma 10.0
25 quadriplegia 10.0
26 neuroendocrine tumor 10.0
27 central nervous system cancer 10.0
28 clear cell sarcoma 10.0
29 spindle cell sarcoma 10.0
30 cervicomedullary junction neoplasm 10.0
31 paraplegia 10.0
32 malignant choroid melanoma 10.0
33 adenoma 10.0
34 intracranial hypertension 10.0
35 47,xyy 10.0
36 chromosomal triplication 10.0
37 chromosome 6p duplication 10.0
38 congenital hydrocephalus 10.0
39 ring chromosome 11 10.0
40 back pain 10.0
41 dysphagia 10.0
42 spasticity 10.0
43 nevus of ota 10.0
44 ring chromosome 10.0
45 melanoma of soft tissue 10.0
46 cellular schwannoma 10.0
47 cowden syndrome 1 9.8
48 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.8
49 meningioma, radiation-induced 9.8
50 meningioma, familial 9.8

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Symptoms & Phenotypes for Melanotic Neurilemmoma

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Drugs & Therapeutics for Melanotic Neurilemmoma

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Search Clinical Trials , NIH Clinical Center for Melanotic Neurilemmoma

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Genetic Tests for Melanotic Neurilemmoma

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Anatomical Context for Melanotic Neurilemmoma

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MalaCards organs/tissues related to Melanotic Neurilemmoma:

41
Brain, Ovary, Spinal Cord
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Publications for Melanotic Neurilemmoma

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Articles related to Melanotic Neurilemmoma:

(show all 15)
# Title Authors PMID Year
1
Pigmented tumors in fallow deer ( Dama dama): 11 cases. 38
28467283 2017
2
Clinicopathologic and molecular analysis of a choroidal pigmented schwannoma in the context of a PTEN hamartoma tumor syndrome. 38
22281088 2012
3
Benign Pigmented Schwannoma of the Great Omentum: Report of a Rare Case and Review of the Literature. 38
21103279 2009
4
[A rare primary tumor of the cerebellopontine angle: melanotic schwannoma, a pigmented tumor with unpredictable prognosis]. 38
18276040 2008
5
Scope of FNAC in the diagnosis of soft tissue tumors--a study from a tertiary cancer referral center in India. 38
17973999 2007
6
Plexiform pigmented schwannoma of the uvea. 38
16500216 2006
7
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors. 38
12088451 2002
8
Abnormal pigmentation of schwannoma attributed to excess production of neuromelanin-like pigment. 38
10792787 2000
9
Pigmented schwannoma of the ventral spinal cord. 38
10342906 1999
10
Coexistence of two different intraspinal tumors. Case report and review of the literature. 38
17031913 1999
11
Meningeal melanocytoma: a case report and literature review. 38
9805360 1998
12
Malignant melanoma arising in a dermoid cyst of the ovary. 38
2044057 1991
13
Malignant pigmented spinal nerve root schwannoma metastasizing in the brain and viscera. 38
2286020 1990
14
Melanotic schwannoma of the orbit. Immunohistochemical and ultrastructural study of a case and survey of the literature. 38
2206515 1990
15
Intraspinal pigmented schwannoma with malignant progression. 38
3228005 1988
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Variations for Melanotic Neurilemmoma

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Expression for Melanotic Neurilemmoma

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Search GEO for disease gene expression data for Melanotic Neurilemmoma.
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Pathways for Melanotic Neurilemmoma

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Pathways related to Melanotic Neurilemmoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
11.67 PRKAR1A NF2 GNAQ
2
Tight junction 37
11.63 NF2 MYH8
3
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 11.54 PRKAR1A MYH8 GNAQ
4
Ca, cAMP and Lipid Signaling 4
11.47 PRKAR1A GNAQ
5
Development A2B receptor- action via G-protein alpha s 22
Show member pathways
 11.42 PRKAR1A GNAQ
6
Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling 22
Show member pathways
 11.11 PRKAR1A GNAQ
7
Development_Hedgehog and PTH signaling pathways in bone and cartilage development 22
10.21 PRKAR1A GNAQ
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GO Terms for Melanotic Neurilemmoma

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Biological processes related to Melanotic Neurilemmoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mesoderm formation GO:0001707 9.16 PRKAR1A NF2
2 blood coagulation GO:0007596 9.13 PRKAR1A GNAQ F10
3 negative regulation of protein kinase activity GO:0006469 8.8 PRKAR1A NF2 GNAQ
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Sources for Melanotic Neurilemmoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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