MCID: MLN009
MIFTS: 28

Melanotic Neurilemmoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Melanotic Neurilemmoma

MalaCards integrated aliases for Melanotic Neurilemmoma:

Name: Melanotic Neurilemmoma 12 15 73
Pigmented Neurilemmoma 12
Melanotic Schwannoma 12
Pigmented Schwannoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3205
NCIt 50 C6970
UMLS 73 C1306247

Summaries for Melanotic Neurilemmoma

MalaCards based summary : Melanotic Neurilemmoma, also known as pigmented neurilemmoma, is related to pten hamartoma tumor syndrome and melanoma. An important gene associated with Melanotic Neurilemmoma is PMEL (Premelanosome Protein), and among its related pathways/superpathways is C-MYB transcription factor network. Affiliated tissues include skin, and related phenotypes are integument and immune system

Related Diseases for Melanotic Neurilemmoma

Diseases related to Melanotic Neurilemmoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 pten hamartoma tumor syndrome 30.1 NF2 PTEN
2 melanoma 28.2 MLANA PMEL PTEN
3 carney complex variant 11.5
4 carney complex, type 1 11.3
5 mediastinal melanocytic neurilemmoma 11.1
6 malignant spindle cell melanoma 10.6 PMEL TYR
7 juvenile xanthogranuloma 10.5 LYZ PMEL
8 hermansky-pudlak syndrome 3 10.4 PMEL TYR
9 gallbladder melanoma 10.3 MLANA PMEL
10 central nervous system sarcoma 10.3 CD68 LYZ
11 malignant giant cell tumor of soft parts 10.3 CD68 LYZ
12 pigmented basal cell carcinoma 10.3 MLANA TYR
13 anaplastic ependymoma 10.3 NF2 PTEN
14 liver sarcoma 10.3 CD68 LYZ
15 granulomatous myositis 10.3 CD68 LYZ
16 epithelioid cell melanoma 10.3 MLANA TYR
17 vogt-koyanagi-harada disease 10.2 PMEL TYR
18 vulvar melanoma 10.2 MLANA TYR
19 ulcerative stomatitis 10.2 CD68 LYZ
20 xanthogranulomatous pyelonephritis 10.1 CD68 LYZ
21 small cell sarcoma 10.1 MLANA NF2
22 balloon cell malignant melanoma 10.1 CD68 MLANA
23 malignant skin fibrous histiocytoma 10.1 MLANA TYR
24 ovarian melanoma 10.1 MLANA PTEN
25 brain sarcoma 10.1 CD68 MLANA
26 xanthogranulomatous cholecystitis 10.1 CD68 LYZ
27 malignant dermis tumor 10.1 MLANA TYR
28 lung meningioma 10.0 CD34 NF2
29 deep angioma 10.0 CD34 TYR
30 psammomatous meningioma 10.0 CD34 NF2
31 meningeal melanocytoma 10.0 CD68 MLANA
32 myxosarcoma 10.0 CD68 MLANA
33 intramuscular hemangioma 10.0 CD34 TYR
34 plexiform schwannoma 10.0 CD34 NF2
35 atypical neurofibroma 9.9 CD34 NF2
36 integumentary system cancer 9.9 MLANA TYR
37 halo nevi 9.9 MLANA PMEL TYR
38 melanoacanthoma 9.9 MLANA PMEL TYR
39 vitiligo-associated multiple autoimmune disease susceptibility 1 9.9 MLANA PMEL TYR
40 retina lymphoma 9.9 CD34 CD68
41 melanoma, uveal 9.9 MLANA PMEL TYR
42 extracutaneous mastocytoma 9.9 CD34 CD68
43 sternum cancer 9.9 CD34 CD68
44 spleen angiosarcoma 9.9 CD34 PTEN
45 glomeruloid hemangioma 9.9 CD34 CD68
46 myositis 9.9
47 sarcoma 9.9
48 esophagitis 9.9
49 adrenal gland hyperfunction 9.9
50 clear cell sarcoma 9.9

Graphical network of the top 20 diseases related to Melanotic Neurilemmoma:



Diseases related to Melanotic Neurilemmoma

Symptoms & Phenotypes for Melanotic Neurilemmoma

MGI Mouse Phenotypes related to Melanotic Neurilemmoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.87 TYR CD34 LYZ MLANA NF2 PMEL
2 immune system MP:0005387 9.85 PTEN TYR CD34 CD68 LYZ NF2
3 neoplasm MP:0002006 9.65 TYR CD34 LYZ NF2 PTEN
4 no phenotypic analysis MP:0003012 9.55 TYR CD68 LYZ MLANA PMEL
5 pigmentation MP:0001186 9.26 TYR MLANA PMEL PTEN
6 skeleton MP:0005390 9.02 PTEN TYR CD68 LYZ NF2

Drugs & Therapeutics for Melanotic Neurilemmoma

Search Clinical Trials , NIH Clinical Center for Melanotic Neurilemmoma

Genetic Tests for Melanotic Neurilemmoma

Anatomical Context for Melanotic Neurilemmoma

MalaCards organs/tissues related to Melanotic Neurilemmoma:

41
Skin

Publications for Melanotic Neurilemmoma

Articles related to Melanotic Neurilemmoma:

(show all 21)
# Title Authors Year
1
Sporadic melanotic schwannoma with overlapping features of melanocytoma bearing a GNA11 mutation in an adolescent girl. ( 28012237 )
2017
2
Psammomatous melanotic schwannoma as a component of Carney complex. ( 26275268 )
2015
3
Malignant psammomatous melanotic schwannoma of the spine: A component of Carney complex. ( 22059131 )
2011
4
Trisomy 6p and ring chromosome 11 in a melanotic schwannoma suggest relation to malignant melanoma rather than conventional schwannoma. ( 21424748 )
2011
5
Melanotic schwannoma: a case with strong CD34 expression, with histogenetic implications. ( 20356686 )
2010
6
Improved discrimination of melanotic schwannoma from melanocytic lesions by combined morphological and GNAQ mutational analysis. ( 20865267 )
2010
7
Orbital and myocardial metastases of a primary pulmonary melanotic schwannoma. ( 20615829 )
2010
8
Intrathoracic psammomatous melanotic schwannoma associated with the Carney complex. ( 18640357 )
2008
9
Fine-needle aspiration cytologic diagnosis of metastatic melanotic schwannoma: familial case of a mother and daughter with Carney's complex and literature review. ( 17230569 )
2007
10
Is clear cell sarcoma a malignant form of psammomatous melanotic schwannoma? Case report. ( 17341045 )
2006
11
Primary intraosseous melanotic schwannoma of the fibula associated with the Carney complex. ( 16930334 )
2006
12
Clinicopathological, immunohistochemical, and ultrastructural study of 13 cases of melanotic schwannoma. ( 16157048 )
2005
13
Esophageal melanotic schwannoma presenting with superior vena caval obstruction. ( 11981713 )
2002
14
Removal of a lumbar melanotic schwannoma via the far-lateral approach in a patient with Carney complex. Case report. ( 10763702 )
2000
15
Melanotic schwannoma mimicking myositis ossificans. ( 10698421 )
2000
16
Epithelioid psammomatous melanotic schwannoma with osseous metaplasia. ( 9823871 )
1998
17
Epithelioid blue nevus and psammomatous melanotic schwannoma: the unusual pigmented skin tumors of the Carney complex. ( 9711672 )
1998
18
Melanotic schwannoma of the sympathetic ganglia: a histologic, immunohistochemical and ultrastructural study. ( 9266452 )
1997
19
Psammomatous melanotic schwannoma of a spinal nerve root. Relationship with the Carney complex. ( 9122034 )
1996
20
Malignant melanotic schwannoma or schwannian melanoma? ( 7571031 )
1995
21
Psammomatous melanotic schwannoma. A distinctive, heritable tumor with special associations, including cardiac myxoma and the Cushing syndrome. ( 2305928 )
1990

Variations for Melanotic Neurilemmoma

Expression for Melanotic Neurilemmoma

Search GEO for disease gene expression data for Melanotic Neurilemmoma.

Pathways for Melanotic Neurilemmoma

Pathways related to Melanotic Neurilemmoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 CD34 LYZ

GO Terms for Melanotic Neurilemmoma

Cellular components related to Melanotic Neurilemmoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome GO:0042470 8.8 MLANA PMEL TYR

Biological processes related to Melanotic Neurilemmoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of protein stability GO:0031647 9.16 NF2 PTEN
2 cell proliferation GO:0008283 9.13 CD34 PTEN TYR
3 melanin biosynthetic process GO:0042438 8.62 PMEL TYR

Sources for Melanotic Neurilemmoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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