MCID: MLN001
MIFTS: 36

Melanotic Neuroectodermal Tumor

Categories: Cancer diseases, Bone diseases, Neuronal diseases

Aliases & Classifications for Melanotic Neuroectodermal Tumor

MalaCards integrated aliases for Melanotic Neuroectodermal Tumor:

Name: Melanotic Neuroectodermal Tumor 12 15
Neuroectodermal Tumor, Melanotic 44 73
Infantile Melanotic Neuroectodermal Neoplasm 12
Pigmented Neuroectodermal Tumour of Infancy 12
Melanotic Neuroectodermal Tumor of Infancy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:166
MeSH 44 D017600
NCIt 50 C3717
UMLS 73 C0206094

Summaries for Melanotic Neuroectodermal Tumor

MalaCards based summary : Melanotic Neuroectodermal Tumor, also known as neuroectodermal tumor, melanotic, is related to epulis and epithelioid leiomyosarcoma. An important gene associated with Melanotic Neuroectodermal Tumor is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include bone, brain and pineal, and related phenotype is behavior/neurological.

Wikipedia : 76 Melanotic neuroectodermal tumor of infancy (MNTI) is a very rare oral cavity tumor that is seen in... more...

Related Diseases for Melanotic Neuroectodermal Tumor

Diseases related to Melanotic Neuroectodermal Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 219)
# Related Disease Score Top Affiliating Genes
1 epulis 30.9 ENO2 VIM
2 epithelioid leiomyosarcoma 10.6 ENO2 VIM
3 ureter small cell carcinoma 10.6 ENO2 SYP
4 malignant sertoli cell tumor 10.6 ENO2 SYP
5 urinary bladder small cell neuroendocrine carcinoma 10.6 ENO2 SYP
6 auditory system cancer 10.6 ENO2 SYP
7 sinonasal undifferentiated carcinoma 10.6 ENO2 SYP
8 sensory organ benign neoplasm 10.6 ENO2 SYP
9 gallbladder small cell carcinoma 10.6 ENO2 SYP
10 pancreatic somatostatinoma 10.6 ENO2 SYP
11 cutaneous ganglioneuroma 10.6 ENO2 SYP
12 extrahepatic bile duct adenocarcinoma 10.6 ENO2 SYP
13 small cell carcinoma of the bladder 10.6 ENO2 SYP
14 orbital cancer 10.6 ENO2 SYP
15 middle ear adenoma 10.6 ENO2 SYP
16 ovarian carcinosarcoma 10.6 ENO2 SYP
17 pulmonary large cell neuroendocrine carcinoma 10.6 ENO2 SYP
18 atypical follicular adenoma 10.6 ENO2 SYP
19 cerebellum cancer 10.6 ENO2 SYP
20 olfactory nerve neoplasm 10.6 ENO2 SYP
21 cauda equina neoplasm 10.6 ENO2 SYP
22 extraosseous chondrosarcoma 10.6 ENO2 SYP
23 chondroid chordoma 10.6 ENO2 VIM
24 malignant teratoma 10.6 ENO2 SYP
25 endometrial small cell carcinoma 10.6 ENO2 SYP
26 nodular ganglioneuroblastoma 10.6 ENO2 SYP
27 mucinous ovarian cystadenoma 10.6 ENO2 SYP
28 respiratory system benign neoplasm 10.6 ENO2 SYP
29 angiomyoma 10.6 ENO2 SYP
30 gastric squamous cell carcinoma 10.6 ENO2 SYP
31 congenital epulis 10.6 ENO2 VIM
32 gastric small cell carcinoma 10.6 ENO2 SYP
33 carcinoid tumors, intestinal 10.5 ENO2 SYP
34 bone benign neoplasm 10.5 ENO2 SYP
35 meningeal melanomatosis 10.5 ENO2 SYP
36 cervical clear cell adenocarcinoma 10.5 ENO2 SYP
37 liver angiosarcoma 10.5 ENO2 VIM
38 connective tissue benign neoplasm 10.5 ENO2 SYP
39 melanotic medulloblastoma 10.5 ENO2 GFAP
40 intraocular retinoblastoma 10.5 ENO2 SYP
41 sclerosing hemangioma 10.5 ENO2 SYP
42 mixed cell type cancer 10.5 ENO2 SYP
43 epithelioid malignant peripheral nerve sheath tumor 10.5 ENO2 S100B
44 cerebellar medulloblastoma 10.5 ENO2 GFAP
45 middle cerebral artery infarction 10.5 ENO2 S100B
46 carcinoid syndrome 10.5 ENO2 SYP
47 cranial nerve malignant neoplasm 10.5 ENO2 SYP
48 perivascular epithelioid cell tumor 10.5 SYP VIM
49 pineal parenchymal tumor of intermediate differentiation 10.5 ENO2 SYP
50 ovarian mucinous neoplasm 10.5 ENO2 SYP

Graphical network of the top 20 diseases related to Melanotic Neuroectodermal Tumor:



Diseases related to Melanotic Neuroectodermal Tumor

Symptoms & Phenotypes for Melanotic Neuroectodermal Tumor

MGI Mouse Phenotypes related to Melanotic Neuroectodermal Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.1 VIM DBH ENO2 GFAP S100B SYP

Drugs & Therapeutics for Melanotic Neuroectodermal Tumor

Search Clinical Trials , NIH Clinical Center for Melanotic Neuroectodermal Tumor

Cochrane evidence based reviews: neuroectodermal tumor, melanotic

Genetic Tests for Melanotic Neuroectodermal Tumor

Anatomical Context for Melanotic Neuroectodermal Tumor

MalaCards organs/tissues related to Melanotic Neuroectodermal Tumor:

41
Bone, Brain, Pineal, Lymph Node

Publications for Melanotic Neuroectodermal Tumor

Articles related to Melanotic Neuroectodermal Tumor:

(show top 50) (show all 187)
# Title Authors Year
1
Clinical and immunohistochemical study of melanotic neuroectodermal tumor of infancy in the maxilla. ( 29768520 )
2018
2
Melanotic neuroectodermal tumor of infancy: A rare case report. ( 29491604 )
2018
3
Melanotic neuroectodermal tumor of infancy (MNTI) of the head and neck: A French multicenter study. ( 29275074 )
2018
4
Melanotic Neuroectodermal Tumor of Infancy in the Maxilla. ( 28968318 )
2018
5
Spontaneous Regression of Diffuse Periosteal Melanotic Neuroectodermal Tumor of Infancy in the Tibia, With 13-Year Follow-up. ( 29621061 )
2018
6
Melanotic neuroectodermal tumor of infancy: a rare presentation of an extremely rare neoplasm and diagnostic implications in Gombe, Nigeria. ( 29138651 )
2017
7
Melanotic Neuroectodermal Tumor of Infancy of the Upper Arm: A Case Report. ( 29179213 )
2017
8
Giant melanotic neuroectodermal tumor of infancy (melanotic progonoma) of the head and neck: report of a malignant case. ( 28291424 )
2017
9
Prenatal Diagnosis of a Melanotic Neuroectodermal Tumor of Infancy (MNTI): A Case Report With a Favorable Outcome After Chemotherapy Failure and Incomplete Resection. ( 29016414 )
2017
10
Melanotic Neuroectodermal Tumor of Infancy Presenting With Fast-Growing Scrotal Swelling: A Case Report and Literature Review. ( 28812465 )
2017
11
Metastatic Melanotic Neuroectodermal Tumor of Infancy: Report of a Case and Review of the Literature. ( 27393580 )
2016
12
Mandibular melanotic neuroectodermal tumor of infancy: a role for neoadjuvant chemotherapy. ( 27107579 )
2016
13
A germline mutation of CDKN2A and a novel RPLP1-C19MC fusion detected in a rare melanotic neuroectodermal tumor of infancy: a case report. ( 27519597 )
2016
14
Melanotic Neuroectodermal Tumor of Infancy in the Epididymis: A Brief Report and Review of the Role of Chemotherapy in Management. ( 26886373 )
2016
15
Obturator Prostheses for Melanotic Neuroectodermal Tumor of Infancy in the Maxilla. ( 26703043 )
2016
16
Melanotic Neuroectodermal Tumor of Infancy. ( 27504436 )
2016
17
Melanotic Neuroectodermal Tumor of Infancy with Involvement of the Superior Sagittal Sinus. ( 27595482 )
2016
18
Clinicopathological features of melanotic neuroectodermal tumor of infancy: Report of two cases. ( 26602435 )
2016
19
Protumorigenic M2-like phenotype cell infiltration in the melanotic neuroectodermal tumor of infancy. ( 26686956 )
2016
20
Melanotic neuroectodermal tumor of infancy: Cytology and histopathology of a rare lesion at an uncommon site. ( 28051837 )
2016
21
Melanotic neuroectodermal tumor of infancy. ( 27095686 )
2016
22
Melanotic Neuroectodermal Tumor of Infancy Presenting with Fast Growing Scrotal Swelling: A Case Report and Literature Review. ( 26669807 )
2015
23
Melanotic Neuroectodermal Tumor of Infancy: A Systematic Review. ( 25936939 )
2015
24
Extensive Melanotic Neuroectodermal Tumor of Infancy. ( 26581397 )
2015
25
Reconstruction of anterior maxillary defect with buccal pad fat after excision of melanotic neuroectodermal tumor of infancy. ( 26981478 )
2015
26
Melanotic neuroectodermal tumor of infancy in the soft tissue of the forearm: report of a case. ( 26722579 )
2015
27
Melanotic neuroectodermal tumor of infancy: review of literature, report of a case and follow up at 7 years. ( 25579681 )
2015
28
Melanotic neuroectodermal tumor of infancy: A case report and review of the surgical treatment. ( 25435930 )
2015
29
Melanotic neuroectodermal tumor of infancy in the skull: a case report. ( 26690602 )
2015
30
Prenatal Diagnosis Of Orbital Melanotic Neuroectodermal Tumor Of Infancy. ( 25594399 )
2015
31
Fine-needle aspiration cytology of melanotic neuroectodermal tumor of infancy. ( 26173836 )
2015
32
BRAFV600E Mutation in Melanotic Neuroectodermal Tumor of Infancy: Toward Personalized Medicine? ( 26122804 )
2015
33
Oral melanotic neuroectodermal tumor of infancy. ( 24531607 )
2014
34
Melanotic Neuroectodermal Tumor of Infancy: A Wolf in Sheep's Clothing. ( 25030945 )
2014
35
Melanotic neuroectodermal tumor of infancy disseminated by a ventriculoperitoneal shunt and diagnosed from the inguinal sac. ( 23823108 )
2014
36
Maxillary melanotic neuroectodermal tumor of infancy management: is conservative surgery the best approach? ( 23851860 )
2013
37
Melanotic Neuroectodermal Tumor of Infancy Arising in the Temporal Bone. ( 23965399 )
2013
38
Melanotic neuroectodermal tumor of infancy in an African-indigenous patient from the Amazon: a case report. ( 24274360 )
2013
39
Melanotic neuroectodermal tumor of infancy in the maxilla. ( 24083035 )
2013
40
Melanotic neuroectodermal tumor of infancy: A rare case report. ( 24403811 )
2013
41
Melanotic neuroectodermal tumor of infancy: A rare case report with differential diagnosis and review of the literature. ( 22557910 )
2012
42
Cigar-shaped melanin granules in melanotic neuroectodermal tumor of infancy. ( 21563320 )
2012
43
Melanotic neuroectodermal tumor of infancy. ( 22092370 )
2012
44
Melanotic neuroectodermal tumor of infancy: a histopathological and immunohistochemical study. ( 22298524 )
2012
45
Melanotic neuroectodermal tumor of infancy: case report and review of the literature. ( 22533073 )
2011
46
Melanotic neuroectodermal tumor of infancy of the maxilla: a case report with review of literature. ( 20619949 )
2011
47
Melanotic neuroectodermal tumor of infancy in thigh of an infant--a rare case report with diagnostic implications. ( 21318270 )
2011
48
Malignant melanotic neuroectodermal tumor of infancy arising in the mandible. ( 22044830 )
2011
49
Melanotic neuroectodermal tumor of infancy: Report of a case associated with high urinary excretion of Vanilmandelic acid. ( 22346163 )
2011
50
Melanotic neuroectodermal tumor of the calvarium. ( 20574653 )
2010

Variations for Melanotic Neuroectodermal Tumor

Expression for Melanotic Neuroectodermal Tumor

Search GEO for disease gene expression data for Melanotic Neuroectodermal Tumor.

Pathways for Melanotic Neuroectodermal Tumor

Pathways related to Melanotic Neuroectodermal Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.89 DBH ENO2 GFAP S100B SYP
2 10.82 GFAP S100B SYP VIM

GO Terms for Melanotic Neuroectodermal Tumor

Biological processes related to Melanotic Neuroectodermal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron projection development GO:0010977 9.4 GFAP VIM
2 long-term synaptic potentiation GO:0060291 9.37 GFAP S100B
3 regulation of neuronal synaptic plasticity GO:0048168 9.32 S100B SYP
4 astrocyte development GO:0014002 9.26 GFAP VIM
5 intermediate filament organization GO:0045109 9.16 GFAP VIM
6 Bergmann glial cell differentiation GO:0060020 8.96 GFAP VIM
7 intermediate filament-based process GO:0045103 8.62 GFAP VIM

Molecular functions related to Melanotic Neuroectodermal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.92 GFAP S100B SYP VIM

Sources for Melanotic Neuroectodermal Tumor

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74 UMLS via Orphanet
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