MCID: MLN001
MIFTS: 33

Melanotic Neuroectodermal Tumor

Categories: Bone diseases, Cancer diseases, Neuronal diseases, Oral diseases

Aliases & Classifications for Melanotic Neuroectodermal Tumor

MalaCards integrated aliases for Melanotic Neuroectodermal Tumor:

Name: Melanotic Neuroectodermal Tumor 12 15 17
Neuroectodermal Tumor, Melanotic 44 70
Infantile Melanotic Neuroectodermal Neoplasm 12
Melanotic Neuroectodermal Tumour of Infancy 12
Pigmented Neuroectodermal Tumour of Infancy 12
Melanotic Neuroectodermal Tumor of Infancy 12
Melanotic Neuroectodermal Tumour 12

Classifications:



External Ids:

Disease Ontology 12 DOID:166
MeSH 44 D017600
NCIt 50 C3717
SNOMED-CT 67 1513001
UMLS 70 C0206094

Summaries for Melanotic Neuroectodermal Tumor

MalaCards based summary : Melanotic Neuroectodermal Tumor, also known as neuroectodermal tumor, melanotic, is related to epulis and teratoma. An important gene associated with Melanotic Neuroectodermal Tumor is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include bone, pineal and brain, and related phenotypes are behavior/neurological and normal

Wikipedia : 73 Melanotic neuroectodermal tumor of infancy is a very rare oral cavity tumor that is seen in patients... more...

Related Diseases for Melanotic Neuroectodermal Tumor

Diseases related to Melanotic Neuroectodermal Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 271)
# Related Disease Score Top Affiliating Genes
1 epulis 30.6 VIM ENO2
2 teratoma 30.5 SYP GFAP ENO2
3 hydrocephalus 30.3 SYP GFAP ENO2
4 desmoplastic small round cell tumor 30.2 VIM SYP MYOG ENO2
5 medulloblastoma 29.8 VIM SYP MDM2 GFAP ENO2
6 rhabdomyosarcoma 29.7 VIM SYP MYOG MDM2 GFAP ENO2
7 neuroblastoma 29.7 SYP MDM2 ENO2 DBH CCNA2
8 ewing sarcoma 29.5 VIM SYP MYOG MDM2 ENO2
9 rare tumor 10.8
10 bednar tumor 10.3 VIM ENO2
11 malignant melanocytic neoplasm of the peripheral nerve sheath 10.3 SYP ENO2
12 congenital epulis 10.3 VIM ENO2
13 anal neuroendocrine tumor 10.3 SYP ENO2
14 optic nerve astrocytoma 10.3 SYP ENO2
15 neuronal intestinal dysplasia, type b 10.3 SYP ENO2
16 ewing sarcoma of bone 10.3 VIM ENO2
17 lung meningioma 10.3 SYP ENO2
18 sinonasal undifferentiated carcinoma 10.3 SYP ENO2
19 auditory system benign neoplasm 10.3 SYP ENO2
20 auditory system cancer 10.3 SYP ENO2
21 cloacogenic carcinoma 10.3 SYP ENO2
22 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.3 SYP ENO2
23 cauda equina neoplasm 10.3 SYP ENO2
24 intracranial primitive neuroectodermal tumor 10.3 SYP ENO2
25 bile duct mucinous adenocarcinoma 10.3 SYP ENO2
26 nodular prostate 10.3 SYP ENO2
27 ampulla of vater benign neoplasm 10.3 SYP ENO2
28 appendix carcinoid tumor 10.3 SYP ENO2
29 carotid body cancer 10.3 SYP ENO2
30 gallbladder small cell carcinoma 10.3 SYP ENO2
31 ureter small cell carcinoma 10.3 SYP ENO2
32 cerebellar liponeurocytoma 10.3 SYP ENO2
33 middle ear adenoma 10.3 SYP ENO2
34 primary hepatic neuroendocrine carcinoma 10.3 VIM SYP
35 glomangiomyoma 10.3 VIM SYP
36 urinary bladder small cell neuroendocrine carcinoma 10.3 SYP ENO2
37 gastric small cell carcinoma 10.3 SYP ENO2
38 intracranial cysts 10.3 GFAP ENO2
39 jejunal neoplasm 10.3 SYP ENO2
40 frontal lobe neoplasm 10.3 SYP ENO2
41 sensory organ benign neoplasm 10.3 SYP ENO2
42 melanoma 10.3
43 ovarian large-cell neuroendocrine carcinoma 10.3 SYP ENO2
44 gastric hemangioma 10.3 SYP ENO2
45 pineal parenchymal tumor of intermediate differentiation 10.3 SYP ENO2
46 cutaneous ganglioneuroma 10.3 SYP ENO2
47 kidney rhabdoid cancer 10.3 SYP ENO2
48 cervix small cell carcinoma 10.3 SYP ENO2
49 adrenal neuroblastoma 10.3 SYP ENO2
50 esophageal adenoid cystic carcinoma 10.3 VIM SYP

Graphical network of the top 20 diseases related to Melanotic Neuroectodermal Tumor:



Diseases related to Melanotic Neuroectodermal Tumor

Symptoms & Phenotypes for Melanotic Neuroectodermal Tumor

MGI Mouse Phenotypes related to Melanotic Neuroectodermal Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.56 BRAF DBH ENO2 GFAP MDM2 MYOG
2 normal MP:0002873 9.17 BRAF DBH GFAP MDM2 MYOG SYP

Drugs & Therapeutics for Melanotic Neuroectodermal Tumor

Search Clinical Trials , NIH Clinical Center for Melanotic Neuroectodermal Tumor

Cochrane evidence based reviews: neuroectodermal tumor, melanotic

Genetic Tests for Melanotic Neuroectodermal Tumor

Anatomical Context for Melanotic Neuroectodermal Tumor

MalaCards organs/tissues related to Melanotic Neuroectodermal Tumor:

40
Bone, Pineal, Brain, Cerebellum, Testis, Eye, Lymph Node

Publications for Melanotic Neuroectodermal Tumor

Articles related to Melanotic Neuroectodermal Tumor:

(show top 50) (show all 264)
# Title Authors PMID Year
1
Odontogenic and Developmental Oral Lesions in Pediatric Patients. 61
33723756 2021
2
Melanotic Neuroectodermal Tumor of Infancy in the Ulna of an Infant: A Very Rare Tumor: A Case Report. 61
33684079 2021
3
[Melanotic neuroectodermal tumor of infancy: a clinicopathological study of three cases]. 61
33535309 2021
4
Melanotic Neuroectodermal Tumor of Infancy (MNTI) and Pineal Anlage Tumor (PAT) Harbor A Medulloblastoma Signature by DNA Methylation Profiling. 61
33572349 2021
5
Calvarial Melanotic Neuroectodermal Tumor of Infancy with Rhabdomyosarcomatous differentiation-A Rare Case. 61
32891846 2021
6
Melanotic neuroectodermal tumor of infancy successfully treated with metformin: A case report. 61
33157911 2020
7
Vascularized Composite Parietal Bone Flap for Immediate Reconstruction of a Hemi-Maxillectomy Defect in an Infant. 61
33136885 2020
8
Appendageal tumors and tumor-like lesions of the testis and paratestis: a 32-year experience at a single institution. 61
32619438 2020
9
Oral pigmented lesions: a retrospective analysis from Brazil. 61
32856618 2020
10
Oral melanotic neuroectodermal tumor of infancy: Management of a case affecting the maxilla. 61
33004733 2020
11
Vascularized Composite Parietal Bone Flap for Immediate Reconstruction of a Hemi-Maxillectomy Defect in an Infant. 61
32675770 2020
12
Ototoxicity after platinum-based chemotherapy in the treatment of melanotic neuroectodermal tumour of infancy. 61
32269613 2020
13
Melanotic neuroectodermal tumor of infancy to the skull: case-based review. 61
31953575 2020
14
Melanotic Neuroectodermal Tumor of Infancy: A Rare Case Report. 61
33110332 2020
15
Melanotic Neuroectodermal Tumor of Infancy, a Rapidly Growing Maxillary Alveolar Mass: A Case Report. 61
32158789 2020
16
Congenital Granular Cell Epulis: Classic Presentation and Its Differential Diagnosis. 61
30888637 2020
17
Melanotic neuroectodermal tumor of infancy arising from the skull: report of an unusual case, review of the literature, and a diagnostic approach. 61
31897638 2020
18
Melanotic neuroectodermal tumor of infancy in ovary: A rare case report. 61
31804335 2019
19
Melanotic Neuroectodermal Tumor of Infancy: A Rare Case Report. 61
32025440 2019
20
Melanotic Neuroectodermal Tumor of Infancy Arising in the Skull and Brain: A Systematic Review. 61
31295620 2019
21
Melanotic Neuroectodermal Tumor Presenting as Endolymphatic Sac Tumor. 61
30955377 2019
22
Spontaneous Regression of Diffuse Periosteal Melanotic Neuroectodermal Tumor of Infancy in the Tibia, With 13-Year Follow-up. 61
29621061 2019
23
Melanotic neuroectodermal tumor of infancy: A rare entity. 61
30967743 2019
24
Epididymal melanotic neuroectodermal tumor of infancy: A rare cause of scrotal mass in an infant. 61
30393869 2019
25
Melanotic Neuroectodermal Tumor of Infancy: Case Report and Review of Management. 61
30392845 2019
26
Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence. 61
30390348 2018
27
Melanotic neuroectodermal tumor of infancy: A rare pediatric head and neck lesion. 61
30178566 2018
28
Melanotic Neuroectodermal Tumor of Infancy. 61
30407852 2018
29
Pigmented lesions of the oral mucosa: A cross-sectional study of 458 histopathological specimens. 61
29945290 2018
30
Use of Technological Aids in the Resection of a Rare Maxillofacial Tumor of Infancy. 61
29846085 2018
31
Melanotic Neuroectodermal Tumor of Infancy: a Clinicopathological Case Report. 61
30462768 2018
32
Aggressive histologic features do not predict biologic behavior in melanotic neuroectodermal tumor of infancy. 61
30158782 2018
33
Prenatal Diagnosis of a Melanotic Neuroectodermal Tumor of Infancy (MNTI): A Case Report With a Favorable Outcome After Chemotherapy Failure and Incomplete Resection. 61
29016414 2018
34
Clinical and immunohistochemical study of melanotic neuroectodermal tumor of infancy in the maxilla. 61
29768520 2018
35
Melanotic neuroectodermal tumor of infancy (MNTI) of the head and neck: A French multicenter study. 61
29275074 2018
36
Melanotic neuroectodermal tumor of infancy: A rare case report. 61
29491604 2018
37
Melanotic Neuroectodermal Tumor of Infancy in the Maxilla. 61
28968318 2018
38
Difficult Nasal Intubation Using Airway Scope® for a Child With Large Tumor. 61
30715950 2018
39
Melanotic Neuroectodermal Tumor of Infancy Presenting With Fast-Growing Scrotal Swelling: A Case Report and Literature Review. 61
28812465 2017
40
Giant melanotic neuroectodermal tumor of infancy (melanotic progonoma) of the head and neck: report of a malignant case. 61
28291424 2017
41
Melanotic neuroectodermal tumor of infancy: Cytology and histopathology of a rare lesion at an uncommon site. 61
28051837 2017
42
Melanotic neuroectodermal tumor of infancy: a rare presentation of an extremely rare neoplasm and diagnostic implications in Gombe, Nigeria. 61
29138651 2017
43
Melanotic Neuroectodermal Tumor of Infancy of the Upper Arm. 61
29179213 2017
44
Anaesthetic Management of a Neuroectodermal Tumor of Infancy: A Rare Case Report. 61
28298796 2017
45
Melanotic Neuroectodermal Tumor of Infancy with Involvement of the Superior Sagittal Sinus. 61
27595482 2017
46
Metastatic Melanotic Neuroectodermal Tumor of Infancy: Report of a Case and Review of the Literature. 61
27393580 2016
47
Mandibular melanotic neuroectodermal tumor of infancy: a role for neoadjuvant chemotherapy. 61
27107579 2016
48
Extensive Melanotic Neuroectodermal Tumor of Infancy. 61
26581397 2016
49
Melanotic neuroectodermal tumor of infancy. 61
27095686 2016
50
Clinicopathological features of melanotic neuroectodermal tumor of infancy: Report of two cases. 61
26602435 2016

Variations for Melanotic Neuroectodermal Tumor

Expression for Melanotic Neuroectodermal Tumor

Search GEO for disease gene expression data for Melanotic Neuroectodermal Tumor.

Pathways for Melanotic Neuroectodermal Tumor

Pathways related to Melanotic Neuroectodermal Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 SYP GFAP ENO2 DBH
2 10.7 VIM SYP GFAP

GO Terms for Melanotic Neuroectodermal Tumor

Biological processes related to Melanotic Neuroectodermal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.61 MELTF DBH BRAF
2 cellular response to estradiol stimulus GO:0071392 9.48 MYOG CCNA2
3 blood vessel remodeling GO:0001974 9.46 MDM2 DBH
4 cellular response to organic substance GO:0071310 9.4 SYP MDM2
5 positive regulation of muscle cell differentiation GO:0051149 9.37 MYOG MDM2
6 intermediate filament organization GO:0045109 9.32 VIM GFAP
7 astrocyte development GO:0014002 9.26 VIM GFAP
8 Bergmann glial cell differentiation GO:0060020 9.16 VIM GFAP
9 negative regulation of neuron projection development GO:0010977 9.13 VIM MDM2 GFAP
10 intermediate filament-based process GO:0045103 8.62 VIM GFAP

Sources for Melanotic Neuroectodermal Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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