MCID: MLD001
MIFTS: 68

Melioidosis

Categories: Blood diseases, Genetic diseases, Immune diseases, Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Melioidosis

MalaCards integrated aliases for Melioidosis:

Name: Melioidosis 56 12 74 52 58 54 3 43 15 71
Melioidosis, Susceptibility to 56 29 39
Burkholderia Pseudomallei Infection 52 3
Acute and Fulminating Melioidosis 12 32
Subacute and Chronic Melioidosis 12 32
Nightcliff Gardener's Disease 12 52
B Pseudomallei Infection 52
Epizootic Lymphangitis 71
Whitmore's Disease 12
Whitmore Disease 52
Pseudoglanders 12

Characteristics:

Orphanet epidemiological data:

58
melioidosis
Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:5052
OMIM 56 615557
ICD9CM 34 025
MeSH 43 D008554
NCIt 49 C128336
SNOMED-CT 67 428111003
MESH via Orphanet 44 D008554
ICD10 via Orphanet 33 A24.1 A24.2 A24.3 more
UMLS via Orphanet 72 C0025229
Orphanet 58 ORPHA31202
UMLS 71 C0025229 C1998095

Summaries for Melioidosis

NIH Rare Diseases : 52 Melioidosis is an infectious disease caused by the bacteria Burkholderia pseudomallei that are commonly found in the soil and water. Melioidosis is a rare disease in the United States, but it is common in tropical or subtropical areas of the world, including Southeast Asia, Africa, and Australia. The signs and symptoms of the disease can vary greatly and may mimic those of tuberculosis or common forms of pneumonia. Signs and symptoms may include pain or swelling, fever, abscess, cough, high fever, headache, trouble breathing, and more. Although healthy people can also experience signs and symptoms of the disease, people with certain conditions like diabetes, liver disease, kidney disease , lung disease, thalassemia , cancer , or certain autoimmune diseases are more severely affected. Diagnosis is made by collecting blood, sputum , urine, or pus samples and growing the bacteria. Current treatment is divided into two stages: an intravenous (IV) antibiotic stage and oral antibiotic maintenance stage to prevent recurrence.

MalaCards based summary : Melioidosis, also known as melioidosis, susceptibility to, is related to cellulitis and pericarditis, and has symptoms including fever, chest pain and respiratory distress. An important gene associated with Melioidosis is TLR5 (Toll Like Receptor 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Trimethoprim and Sulfamethoxazole have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and liver, and related phenotypes are fever and sepsis

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, has material basis in Burkholderia pseudomallei, which is transmitted by contact with the contaminated water or soil. The infection has symptom fever, has symptom respiratory distress, has symptom chest pain, and has symptom stomach pain.

OMIM : 56 Melioidosis is infection caused by the gram-negative, flagellated soil saprophyte Burkholderia pseudomallei, which is endemic in parts of southeast Asia and northern Australia. Sepsis is a common clinical presentation of disease, and lung is the organ most commonly involved. In northern Thailand, where B. pseudomallei is the most common bloodstream isolate, the overall melioidosis mortality rate exceeds 40%, and pneumonia confers more than 2-fold increased risk of death (summary by West et al., 2013). (615557)

CDC : 3 Melioidosis, also called Whitmore's disease, is an infectious disease that can infect humans or animals. The disease is caused by the bacterium Burkholderia pseudomallei. It is predominately a disease of tropical climates, especially in Southeast Asia and northern Australia where it is widespread. The bacteria causing melioidosis are found in contaminated water and soil. It is spread to humans and animals through direct contact with the contaminated source.

Wikipedia : 74 Melioidosis is an infectious disease caused by a gram-negative bacterium called Burkholderia... more...

Related Diseases for Melioidosis

Diseases related to Melioidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 627)
# Related Disease Score Top Affiliating Genes
1 cellulitis 31.0 TNF IL6 IL10 IFNG
2 pericarditis 30.8 TNF IL6 IFNG
3 meningoencephalitis 30.8 TNF IL6 IL10
4 lung abscess 30.8 TNF IL6 IFNG
5 bronchopneumonia 30.7 TNF TLR4 IL6 IL10
6 prostatitis 30.7 TNF IL6 IL10
7 fasciitis 30.7 TNF IL6 IL18 IFNG
8 tularemia 30.6 TNF TLR4 TLR2 IL18
9 legionnaire disease 30.6 TLR5 TLR4 TLR2
10 septic arthritis 30.6 TREM1 TNF TLR5 TLR4 TLR2 IL6
11 epidemic typhus 30.6 TLR5 TLR4 TLR2 IL10
12 suppurative otitis media 30.4 TLR5 TLR4 TLR2
13 endocarditis 30.4 TNF TLR2 IL6 IL10 IFNG
14 osteomyelitis 30.4 TNF TLR4 TLR2 NOD2 IL6 IL10
15 myelitis 30.4 TNF IL6 IL10
16 typhoid fever 30.4 TNF TLR5 TLR4 IL6 IFNG
17 lymphadenitis 30.3 TNF TLR4 NOD2 IL18 IL10 IFNG
18 infective endocarditis 30.3 TREM1 TNF TLR2 IL6
19 chronic kidney disease 30.3 TNF TLR4 IL6 IL10 HMGB1
20 transverse myelitis 30.3 TNF IL6 IL10
21 leptospirosis 30.3 TNF TLR2 TLR1 IL6 IL18 IL10
22 tetanus 30.3 TNF IL6 IL10 IFNG
23 pulmonary tuberculosis 30.3 TNF TLR4 TLR2 IL6 IL18 IL10
24 orchitis 30.3 TNF IL6 IL10
25 miliary tuberculosis 30.3 TNF IFNG CSF3
26 gastrointestinal tuberculosis 30.3 TNF NOD2 IFNG
27 encephalitis 30.3 TNF TLR2 IL6 IL10 CXCL9
28 exanthem 30.2 TNF IL6 IL10 IFNG CSF3
29 adult-onset still's disease 30.2 TNF IL6 IL18
30 neutropenia 30.2 TNF TLR4 IL6 IL10 IFNG CSF3
31 spinal cord disease 30.2 TNF IL6 IL10
32 dengue hemorrhagic fever 30.2 TNF IL6 IL18 IL10 IFNG
33 hemophagocytic lymphohistiocytosis 30.2 TNF IL18 IL10 IFNG
34 pleural disease 30.1 TNF IL6 IFNG
35 acquired immunodeficiency syndrome 30.1 TNF IL6 IL15 IL10 IFNG
36 purpura 30.1 TNF IL6 IL10 IFNG
37 rheumatic heart disease 30.1 TNF TLR2 IL6 IL10
38 aseptic meningitis 30.1 TNF IL10 IFNG CSF3
39 viral encephalitis 30.1 TNF IL6 IL10 CXCL9
40 endophthalmitis 30.1 TNF TLR2 IL6 HMGB1
41 acute pyelonephritis 30.1 IL6 IL10 IFNG CSF3
42 spondylitis 30.1 TNF NOD2 IL6 IL10 IFNG
43 cholangitis 30.1 TNF TLR4 NOD2 IL6 IL10
44 plague 30.1 TNF TLR5 TLR4 TLR2 TLR1 IL6
45 pyelonephritis 30.1 TNF TLR4 IL6 IL10 IFNG CSF3
46 intestinal perforation 30.1 TNF TLR4 NOD2 IL6
47 mastitis 30.0 TLR2 NOD2 IL6 IL18
48 lupus erythematosus 30.0 TNF TLR5 IL10 IFNG HMGB1
49 lepromatous leprosy 30.0 TNF TLR2 IL18 IL10 IFNG
50 endometritis 30.0 TNF TLR4 TLR2 TLR1 IL6

Graphical network of the top 20 diseases related to Melioidosis:



Diseases related to Melioidosis

Symptoms & Phenotypes for Melioidosis

Human phenotypes related to Melioidosis:

58 31 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
2 sepsis 58 31 frequent (33%) Frequent (79-30%) HP:0100806
3 pneumonia 58 31 frequent (33%) Frequent (79-30%) HP:0002090
4 acute infectious pneumonia 58 31 frequent (33%) Frequent (79-30%) HP:0011949
5 shock 58 31 frequent (33%) Frequent (79-30%) HP:0031273
6 lung abscess 58 31 frequent (33%) Frequent (79-30%) HP:0025044
7 bacteremia 58 31 frequent (33%) Frequent (79-30%) HP:0031864
8 hepatitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012115
9 cellulitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100658
10 osteoarthritis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002758
11 liver abscess 58 31 occasional (7.5%) Occasional (29-5%) HP:0100523
12 septic arthritis 58 31 occasional (7.5%) Occasional (29-5%) HP:0003095
13 brain abscess 58 31 occasional (7.5%) Occasional (29-5%) HP:0030049
14 splenic abscess 58 31 occasional (7.5%) Occasional (29-5%) HP:0025059
15 cutaneous abscess 58 31 occasional (7.5%) Occasional (29-5%) HP:0031292
16 unusual skin infection 58 31 occasional (7.5%) Occasional (29-5%) HP:0032162
17 prostatitis 58 31 very rare (1%) Very rare (<4-1%) HP:0000024
18 parotitis 58 31 very rare (1%) Very rare (<4-1%) HP:0011850
19 foot osteomyelitis 58 31 very rare (1%) Very rare (<4-1%) HP:0001886
20 abnormality of the spleen 58 Occasional (29-5%)
21 abnormality of the genitourinary system 58 Very rare (<4-1%)
22 respiratory tract infection 58 Frequent (79-30%)
23 abnormal parotid gland morphology 58 Very rare (<4-1%)

Clinical features from OMIM:

615557

Symptoms:

12
  • fever
  • chest pain
  • respiratory distress
  • stomach pain

MGI Mouse Phenotypes related to Melioidosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.22 CD14 CSF3 IFNG IL10 IL15 IL18
2 growth/size/body region MP:0005378 10.15 CD14 IFNG IL10 IL15 IL18 IL6
3 homeostasis/metabolism MP:0005376 10.07 CD14 IFNG IL10 IL18 IL6 IRAK3
4 digestive/alimentary MP:0005381 10.06 IFNG IL10 IL18 IL6 NOD2 TLR2
5 immune system MP:0005387 10.06 CD14 CSF3 IFNG IL10 IL15 IL18
6 adipose tissue MP:0005375 9.98 CD14 IL18 IL6 TLR2 TLR4 TLR5
7 neoplasm MP:0002006 9.5 IFNG IL10 IL6 TLR2 TLR4 TNF
8 respiratory system MP:0005388 9.23 CD14 IFNG IL10 IL6 TLR2 TLR4

Drugs & Therapeutics for Melioidosis

Drugs for Melioidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
2
Sulfamethoxazole Approved Phase 4 723-46-6 5329
3 Anti-Infective Agents Phase 4
4 Antiprotozoal Agents Phase 4
5 Anti-Bacterial Agents Phase 4
6 Antiparasitic Agents Phase 4
7 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
8 Antimalarials Phase 4
9
Ceftazidime Approved 72558-82-8, 78439-06-2 5481173
10
Meropenem Approved, Investigational 96036-03-2, 119478-56-7 441130 64778
11 Pharmaceutical Solutions
12 Immunoglobulins
13 Antibodies
14 Immunoglobulins, Intravenous
15 Immunologic Factors
16 Immunoglobulin M
17 Immunoglobulin G

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Comparison Between 12 vs. 20 Weeks of Co-trimoxazole as Maintenance Therapy for Melioidosis Completed NCT01420341 Phase 4 Co-trimoxazole 12;Co-trimoxazole 20
2 Clinical Presentation of Melioidosis in Head and Neck Region Unknown status NCT03048513
3 A Randomized Double Blinded Comparison of Ceftazidime and Meropenem in Severe Melioidosis Unknown status NCT00579956 Meropenem;Ceftazidime
4 A Single-blind Stepped Wedge Cluster Randomized Controlled Behaviour Change Trial to Determine Effectiveness of Prevention Programme of Melioidosis in Diabetics in Ubon Ratchathani, Northeast Thailand Completed NCT02089152
5 Adapting a Rapid Lateral Flow Burkholderia Pseudomallei Immunoassay in Sarawak, Malaysia Completed NCT03528265
6 A Cross-sectional Study Investigating the Causes of Pneumonia in Two Community Clinics in Two Yangon Townships, Myanmar Completed NCT03578133
7 Establishment of a Reference Clinical Sample Panel Allowing for the Development and Proof-of-concept Validation of an In-vitro Diagnostic Test for the Diagnosis of Melioidosis Completed NCT02668406
8 Evaluation of Rapid Diagnostic Tests (RDT) in Association With Clinical and Laboratory Predictors for the Diagnosis of Neglected Tropical Diseases (NTD) in Patients Presenting With Persistent Fever (≥1 Week) in Cambodia, Nepal, Democratic Republic of the Congo and Sudan Completed NCT01766830
9 Diagnostic Accuracy of the DPP Fever Panel II Asia and the DPP Micro Reader Recruiting NCT04299412

Search NIH Clinical Center for Melioidosis

Cochrane evidence based reviews: melioidosis

Genetic Tests for Melioidosis

Genetic tests related to Melioidosis:

# Genetic test Affiliating Genes
1 Melioidosis, Susceptibility to 29 TLR5

Anatomical Context for Melioidosis

MalaCards organs/tissues related to Melioidosis:

40
Lung, Testes, Liver, Brain, Skin, Kidney, Prostate

Publications for Melioidosis

Articles related to Melioidosis:

(show top 50) (show all 2594)
# Title Authors PMID Year
1
Impaired TLR5 functionality is associated with survival in melioidosis. 56 61
23447684 2013
2
Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis). 54 61
17676990 2007
3
Induction of multiple chemokine and colony-stimulating factor genes in experimental Burkholderia pseudomallei infection. 54 61
11564157 2001
4
The CXC chemokines gamma interferon (IFN-gamma)-inducible protein 10 and monokine induced by IFN-gamma are released during severe melioidosis. 61 54
10858199 2000
5
Talus osteomyelitis: An uncommon manifestation of melioidosis. 61
32504801 2020
6
Melioidosis in Gujarat: a neglected tropical disease. 61
32529910 2020
7
MELIOIDOSIS IN A BOTTLENOSE DOLPHIN (TURSIOPS TRUNCATUS) AFTER A HURRICANE IN THE CARIBBEAN ISLANDS. 61
32549577 2020
8
Point-of-Care Ultrasound in the Diagnosis of Melioidosis in Laos. 61
32484153 2020
9
Detection of spleen abscesses facilitates diagnosis of melioidosis in Malaysian children. 61
32535300 2020
10
Melioidosis in a Resident of Texas with No Recent Travel History, United States. 61
32442394 2020
11
Longitudinal profiling of plasma cytokines in melioidosis and their association with mortality: a prospective cohort study. 61
31705997 2020
12
Bacterial-induced cell fusion is a danger signal triggering cGAS-STING pathway via micronuclei formation. 61
32571920 2020
13
Mapping the probability of detecting Burkholderia pseudomallei in rural rice paddy soil based on indicator kriging and spatial soil factor analysis. 61
32484871 2020
14
Regulation of Virulence by Two-Component Systems in Pathogenic Burkholderia. 61
32284365 2020
15
ScmR, a Global Regulator of Gene Expression, Quorum Sensing, pH Homeostasis, and Virulence in Burkholderia thailandensis. 61
32312745 2020
16
Melioidosis: Case reports of confirmed Burkholderia pseudomallei in Saudi Arabia. 61
32156532 2020
17
Melioidosis Presenting with Membranous Tonsillitis and Erythema Nodosum. 61
32444527 2020
18
Systemic Melioidosis With Ruptured Splenic Abscess. 61
32509481 2020
19
Is GSK3β a molecular target of chloroquine treatment against COVID-19? 61
32321878 2020
20
Suppurative cervical lymphadenitis in adult: An analysis of predictors for surgical drainage. 61
32370913 2020
21
A Young Diabetic Patient With Sepsis After Gardening. 61
32494583 2020
22
In silico prediction of host-pathogen protein interactions in melioidosis pathogen Burkholderia pseudomallei and human reveals novel virulence factors and their targets. 61
32444871 2020
23
Indirect Detection of Burkholderia pseudomallei Infection in a US Marine After Training in Australia. 61
32391401 2020
24
Septic arthritis of knee due to Burkholderia pseudomallei: a case report. 61
32437295 2020
25
Revisiting aminocoumarins for the treatment of melioidosis. 61
32361027 2020
26
Burkholderia pseudomallei was Identified in a Melioidosis Aneurysm using Polymerase Chain Reaction Targeting 23S rRNA. 61
32339680 2020
27
Adapting microarray gene expression signatures for early melioidosis diagnosis. 61
32350042 2020
28
Sulfonium Acids Loaded onto an Unusual Thiotemplate Assembly Line Construct the Cyclopropanol Warhead of a Burkholderia Virulence Factor. 61
32314848 2020
29
A role for tetraspanin proteins in regulating fusion induced by Burkholderia thailandensis. 61
32253503 2020
30
Survival of Burkholderia pseudomallei and Pathogenic Leptospira in Cola, Beer, Energy Drinks, and Sports Drinks. 61
32274989 2020
31
Laser Scanning Confocal Microscopy Was Used to Validate the Presence of Burkholderia Pseudomallei or B. Mallei in Formalin-Fixed Paraffin Embedded Tissues. 61
32365605 2020
32
Burkholderia ubonensis Meropenem Resistance: Insights into Distinct Properties of Class A β-Lactamases in Burkholderia cepacia Complex and Burkholderia pseudomallei Complex Bacteria. 61
32291300 2020
33
Melioidosis after a long silence in Sri Lanka: an environmental hazard and dilemma in diagnosis, with recovery and longitudinal follow-up for 13 years: a case report. 61
32303247 2020
34
Burkholderia pseudomallei pathogenesis and survival in different niches. 61
32167134 2020
35
Melioidosis In Suspected Recurrent Tuberculosis: A disease in disguise. 61
32235093 2020
36
Three New Cases of Melioidosis, Guadeloupe, French West Indies. 61
32091384 2020
37
Human Immune Responses to Melioidosis and Cross-Reactivity to Low-Virulence Burkholderia Species, Thailand1. 61
32091359 2020
38
Disseminated melioidosis in early pregnancy - an unproven cause of foetal loss. 61
32143598 2020
39
Medical Devices for Low- and Middle-Income Countries: A Review and Directions for Development. 61
32328210 2020
40
Human Melioidosis. 61
32161067 2020
41
Functional and structural analysis of trehalose-6-phosphate phosphatase from Burkholderia pseudomallei: Insights into the catalytic mechanism. 61
31973820 2020
42
Pathogen to commensal? Longitudinal within-host population dynamics, evolution, and adaptation during a chronic >16-year Burkholderia pseudomallei infection. 61
32134991 2020
43
Disruption of the Burkholderia pseudomallei two-component signal transduction system BbeR-BbeS leads to increased extracellular DNA secretion and altered biofilm formation. 61
32122607 2020
44
Burkholderia pseudomallei peri-prosthetic infection following medial malleolar internal fixation: a case report. 61
32192457 2020
45
Whole-genome sequencing of Burkholderia pseudomallei from an urban melioidosis hot spot reveals a fine-scale population structure and localised spatial clustering in the environment. 61
32214186 2020
46
Development of an immunoassay using recombinant outer membrane protein A and flagellin for diagnosis of goats with melioidosis. 61
31996495 2020
47
Cranial Melioidosis Presenting as Osteomyelitis and/or Extra-Axial Abscess: Literature Review. 61
31629141 2020
48
Systemic Melioidosis with Acute Osteomyelitis and Septic Arthritis Misdiagnosed as Tuberculosis: A Case Report. 61
32211247 2020
49
The Impact of Age and Sex on Mouse Models of Melioidosis. 61
32054106 2020
50
A Two Biomarker Model Augments Clinical Prediction of Mortality in Melioidosis. 61
32034914 2020

Variations for Melioidosis

Expression for Melioidosis

LifeMap Discovery
Genes differentially expressed in tissues of Melioidosis patients vs. healthy controls: 35 (show top 50) (show all 181)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 CD177 CD177 molecule Blood + 8.41 0.000
2 ZDHHC19 zinc finger, DHHC-type containing 19 Blood + 6.91 0.000
3 MMP8 matrix metallopeptidase 8 Blood + 6.49 0.000
4 SLC51A solute carrier family 51, alpha subunit Blood + 6.46 0.000
5 HP haptoglobin Blood + 6.23 0.000
6 FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide Blood - 6.00 0.000
7 GPR84 G protein-coupled receptor 84 Blood + 5.86 0.000
8 ANKRD22 ankyrin repeat domain 22 Blood + 5.72 0.000
9 OLAH oleoyl-ACP hydrolase Blood + 5.54 0.000
10 LRRN3 leucine rich repeat neuronal 3 Blood - 5.51 0.000
11 PCOLCE2 procollagen C-endopeptidase enhancer 2 Blood + 5.47 0.000
12 C1QC complement component 1, q subcomponent, C chain Blood + 5.42 0.000
13 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Blood + 5.39 0.000
14 CCNA1 cyclin A1 Blood + 5.14 0.000
15 C1QB complement component 1, q subcomponent, B chain Blood + 5.09 0.000
16 LINC00668 long intergenic non-protein coding RNA 668 Blood + 4.99 0.000
17 CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit Blood + 4.98 0.000
18 FGF13 fibroblast growth factor 13 Blood + 4.96 0.000
19 NOV nephroblastoma overexpressed Blood - 4.84 0.000
20 PLVAP plasmalemma vesicle associated protein Blood - 4.76 0.000
21 KL klotho Blood + 4.74 0.000
22 SLCO4A1 solute carrier organic anion transporter family, member 4A1 Blood + 4.73 0.000
23 MYO10 myosin X Blood + 4.68 0.000
24 SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 Blood + 4.68 0.000
25 RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 Blood - 4.67 0.000
26 RETN resistin Blood + 4.65 0.000
27 CD274 CD274 molecule Blood + 4.44 0.000
28 MCEMP1 mast cell-expressed membrane protein 1 Blood + 4.44 0.000
29 BMX BMX non-receptor tyrosine kinase Blood + 4.41 0.000
30 SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 Blood + 4.38 0.000
31 CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) Blood + 4.38 0.000
32 GRB10 growth factor receptor-bound protein 10 Blood + 4.37 0.000
33 CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 Blood - 4.25 0.000
34 LINC01220 long intergenic non-protein coding RNA 1220 Blood + 4.20 0.000
35 LTF lactotransferrin Blood + 4.19 0.000
36 SLC26A8 solute carrier family 26 (anion exchanger), member 8 Blood + 4.18 0.000
37 ARG1 arginase 1 Blood + 4.17 0.000
38 IL18R1 interleukin 18 receptor 1 Blood + 4.17 0.000
39 IL1R2 interleukin 1 receptor, type II Blood + 4.08 0.000
40 SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 Blood + 4.06 0.000
41 CFH complement factor H Blood + 4.03 0.000
42 G0S2 G0/G1 switch 2 Blood + 4.02 0.000
43 MMP9 matrix metallopeptidase 9 Blood + 3.97 0.000
44 FCAR Fc fragment of IgA receptor Blood + 3.94 0.000
45 SCN9A sodium channel, voltage gated, type IX alpha subunit Blood + 3.94 0.000
46 FAM20A family with sequence similarity 20, member A Blood + 3.94 0.000
47 KRTAP19-6 keratin associated protein 19-6 Blood + 3.93 0.000
48 TDRD9 tudor domain containing 9 Blood + 3.92 0.000
49 KREMEN1 kringle containing transmembrane protein 1 Blood + 3.86 0.000
50 HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 Blood + 3.84 0.000
Search GEO for disease gene expression data for Melioidosis.

Pathways for Melioidosis

Pathways related to Melioidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 TREM1 TNF TLR5 TLR4 TLR2 TLR10
2
Show member pathways
13.78 TNF TLR4 LY96 IL6 IL18 IL15
3
Show member pathways
13.69 TLR5 TLR4 TLR2 TLR10 TLR1 NOD2
4
Show member pathways
13.51 TNF TLR5 TLR4 TLR2 TLR10 TLR1
5
Show member pathways
13.47 TNF NOD2 IRAK3 IL6 IL18 IL15
6
Show member pathways
13.36 TNF IL6 IL18 IL15 IL10 CXCL9
7
Show member pathways
13.35 TREM1 TNF TLR5 TLR4 TLR2 TLR10
8
Show member pathways
13.07 TREM1 TNF TLR5 TLR4 TLR2 TLR1
9
Show member pathways
12.95 TNF IL6 IL15 IL10 IFNG CXCL9
10
Show member pathways
12.91 TNF TLR4 TLR2 IL6 IL18 IFNG
11
Show member pathways
12.86 TNF TLR5 TLR4 TLR2 TLR10 TLR1
12
Show member pathways
12.78 TNF TLR5 TLR4 TLR2 TLR10 TLR1
13
Show member pathways
12.76 TNF TLR5 TLR4 TLR2 NOD2 IL6
14
Show member pathways
12.74 TNF IL6 IL18 IL10 IFNG CXCL9
15
Show member pathways
12.73 TNF TLR5 TLR4 TLR2 TLR10 TLR1
16
Show member pathways
12.72 TNF TLR4 TLR2 IL6 IL10 IFNG
17 12.69 TNF TLR2 TLR1 IRAK3 IL10 IFNG
18
Show member pathways
12.58 TLR4 TLR2 TLR1 LY96 CD14
19
Show member pathways
12.57 TLR5 TLR4 TLR2 TLR10 TLR1 LY96
20
Show member pathways
12.53 IL6 IL15 IL10 IFNG CSF3
21 12.5 TNF TLR5 TLR4 IL18 CD14
22
Show member pathways
12.49 TNF TLR5 TLR2 IL6 IFNG CSF3
23
Show member pathways
12.48 TNF TLR4 LY96 IRAK3 IL6 IFNG
24 12.47 TNF TLR5 TLR4 TLR2 LY96 IL6
25
Show member pathways
12.45 TLR5 TLR4 LY96 CD14
26
Show member pathways
12.45 TNF IL6 IL18 IL10 CXCL9
27
Show member pathways
12.42 TNF TLR4 TLR2 LY96 IL10 IFNG
28 12.39 TNF TLR5 TLR4 IL6 IL18
29
Show member pathways
12.39 TNF IL6 IL18 IL15 IL10 IFNG
30 12.36 TNF TLR4 NOD2 IL6 IL18
31 12.31 TNF TLR5 TLR4 TLR2 TLR10 TLR1
32
Show member pathways
12.3 TNF TLR5 TLR4 TLR2 TLR10 TLR1
33
Show member pathways
12.27 TNF TLR4 IFNG HMGB1
34
Show member pathways
12.18 TLR5 TLR4 TLR2 TLR10 TLR1
35 12.18 TNF IL6 IL15 IL10 IFNG CSF3
36 12.16 TNF TLR4 IL6 IL18 IL10
37 12.11 TNF TLR4 IL6 IFNG
38 12.11 TNF TLR4 TLR2 TLR1 NOD2 IL6
39 12.09 TNF IL6 IL18 IL10
40 12.09 TNF TLR4 TLR2 IL6 IL10 IFNG
41 12.08 TNF TLR4 LY96 IRAK3 CD14
42 12.07 TNF NOD2 IL6 IL15
43 12.04 TNF TLR4 LY96 CD14
44
Show member pathways
12.04 TLR4 LY96 IL6 CSF3 CD14
45 12.04 TNF TLR4 TLR2 IL6 IL18 IL15
46 12.02 TNF IL6 CSF3 CD14
47
Show member pathways
12.01 TLR5 TLR4 TLR2 TLR10 TLR1 IL6
48 12 TLR5 TLR4 TLR2 TLR10 TLR1
49 11.96 TNF IL18 IL15 IL10 IFNG
50 11.94 TNF TLR4 LY96 IL6 IL10 CD14

GO Terms for Melioidosis

Cellular components related to Melioidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.86 TNF TLR4 TLR2 SERPINF2 NOD2 IL15
2 extracellular region GO:0005576 9.77 TREM1 TNF SERPINF2 LY96 IL6 IL18
3 membrane raft GO:0045121 9.71 TNF TLR2 TLR1 CD14
4 intrinsic component of plasma membrane GO:0031226 9.54 TLR4 TLR2 LY96
5 extracellular space GO:0005615 9.4 TNF SERPINF2 LY96 IL6 IL18 IL15
6 lipopolysaccharide receptor complex GO:0046696 9.33 TLR4 LY96 CD14
7 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.32 TLR2 TLR1

Biological processes related to Melioidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.4 TLR5 TLR4 TLR2 TLR10 TLR1 IRAK3
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.34 TNF TLR4 TLR2 SERPINF2 NOD2 IL6
3 immune system process GO:0002376 10.24 TLR5 TLR4 TLR2 TLR10 TLR1 NOD2
4 innate immune response GO:0045087 10.22 TREM1 TLR5 TLR4 TLR2 TLR10 TLR1
5 positive regulation of gene expression GO:0010628 10.2 TNF TLR4 TLR2 IL6 IL18 IFNG
6 cytokine-mediated signaling pathway GO:0019221 10.15 TNF IRAK3 IL6 IL18 IL10 CSF3
7 defense response to bacterium GO:0042742 10.12 TNF TLR5 TLR4 NOD2 IL10
8 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.1 TNF TLR4 SERPINF2 NOD2 HMGB1
9 immune response GO:0006955 10.1 TNF TLR4 TLR2 TLR10 TLR1 IL6
10 response to lipopolysaccharide GO:0032496 10.09 TLR4 TLR2 LY96 IRAK3 IL10 CD14
11 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.08 TNF TLR4 TLR2 NOD2 IRAK3 IL6
12 defense response GO:0006952 10.05 TNF TLR1 NOD2 CXCL9
13 positive regulation of JNK cascade GO:0046330 10.04 TNF TLR4 SERPINF2 NOD2 HMGB1
14 positive regulation of DNA-binding transcription factor activity GO:0051091 10.03 TNF IL6 IL10 CSF3
15 apoptotic signaling pathway GO:0097190 10 TNF TLR4 LY96 CD14
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10 TNF IL6 IL18 IL15 IFNG
17 positive regulation of inflammatory response GO:0050729 10 TNF TLR4 TLR2 TLR10 IL18 IL15
18 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.99 TNF TLR4 LY96 CD14
19 positive regulation of smooth muscle cell proliferation GO:0048661 9.99 TNF SERPINF2 IL6 IL18
20 humoral immune response GO:0006959 9.99 TREM1 TNF IL6 IFNG
21 positive regulation of interleukin-6 production GO:0032755 9.99 TNF TLR4 TLR2 NOD2 IL6 HMGB1
22 positive regulation of tumor necrosis factor production GO:0032760 9.97 TLR4 TLR2 NOD2 LY96 HMGB1 CD14
23 positive regulation of interferon-gamma production GO:0032729 9.96 TNF TLR4 IL18 CD14
24 positive regulation of nitric oxide biosynthetic process GO:0045429 9.96 TNF TLR5 TLR4 IFNG
25 negative regulation of interleukin-6 production GO:0032715 9.95 TNF TLR4 IRAK3 IL10
26 positive regulation of cytokine secretion GO:0050715 9.95 TNF IL10 IFNG CD14
27 positive regulation of interleukin-6 secretion GO:2000778 9.95 TNF TLR4 TLR2 IFNG HMGB1
28 cellular response to organic cyclic compound GO:0071407 9.94 TNF NOD2 IL18
29 response to glucocorticoid GO:0051384 9.94 TNF IL6 IL10
30 negative regulation of tumor necrosis factor production GO:0032720 9.93 TLR4 IRAK3 IL10
31 positive regulation of interleukin-12 production GO:0032735 9.93 TLR4 TLR2 IFNG HMGB1
32 positive regulation of interleukin-10 production GO:0032733 9.93 TLR4 TLR2 NOD2 HMGB1
33 positive regulation of phagocytosis GO:0050766 9.92 TNF IL15 IFNG
34 positive regulation of interleukin-1 beta secretion GO:0050718 9.91 TLR4 NOD2 HMGB1
35 positive regulation of cytokine production GO:0001819 9.91 TNF TLR5 IL15
36 positive regulation of JAK-STAT cascade GO:0046427 9.91 TNF IL6 IL10
37 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.91 TNF TLR4 NOD2 IL6
38 lipopolysaccharide-mediated signaling pathway GO:0031663 9.91 TNF TLR4 TLR2 LY96 IL18 CD14
39 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.91 TNF TLR4 TLR2 NOD2 IL18 HMGB1
40 negative regulation of interferon-gamma production GO:0032689 9.9 TLR4 IL10 HMGB1
41 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.9 TLR4 LY96 CD14
42 microglial cell activation GO:0001774 9.9 TNF TLR2 IFNG
43 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.88 TLR4 TLR1 IFNG
44 necroptotic process GO:0070266 9.88 TLR4 LY96 CD14
45 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.88 TLR4 LY96 CD14
46 positive regulation of chemokine production GO:0032722 9.88 TNF TLR4 TLR2 IL6
47 positive regulation of interleukin-8 secretion GO:2000484 9.88 TNF TLR4 TLR2 TLR1 CD14
48 positive regulation of interleukin-8 production GO:0032757 9.88 TNF TLR5 TLR4 TLR2 NOD2 HMGB1
49 toll-like receptor 4 signaling pathway GO:0034142 9.87 TLR4 LY96 CD14
50 positive regulation of interleukin-17 production GO:0032740 9.87 NOD2 IL18 IL15

Molecular functions related to Melioidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.39 TNF TLR5 TLR4 TLR2 TLR10 TLR1
2 signaling receptor activity GO:0038023 9.85 TREM1 TLR5 TLR4 TLR2 TLR10 TLR1
3 lipopeptide binding GO:0071723 9.58 TLR2 TLR1 CD14
4 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.56 TLR4 TLR2 TLR10 TLR1
5 lipopolysaccharide receptor activity GO:0001875 9.5 TLR4 TLR2 LY96
6 NAD(P)+ nucleosidase activity GO:0050135 9.46 TLR4 TLR2 TLR10 TLR1
7 lipopolysaccharide binding GO:0001530 9.35 TLR4 TLR2 LY96 HMGB1 CD14
8 cytokine activity GO:0005125 9.28 TNF IL6 IL18 IL15 IL10 IFNG

Sources for Melioidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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