MCID: MLD001
MIFTS: 72

Melioidosis

Categories: Genetic diseases, Rare diseases, Infectious diseases, Immune diseases

Aliases & Classifications for Melioidosis

MalaCards integrated aliases for Melioidosis:

Name: Melioidosis 57 12 76 53 59 55 3 44 15 73
Melioidosis, Susceptibility to 57 29 40
Nightcliff Gardener's Disease 12 53
Whitmore's Disease 12 3
Burkholderia Pseudomallei Infection 53
Acute and Fulminating Melioidosis 12
Subacute and Chronic Melioidosis 12
B Pseudomallei Infection 53
Epizootic Lymphangitis 73
Whitmore Disease 53
Pseudoglanders 12

Characteristics:

Orphanet epidemiological data:

59
melioidosis
Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

OMIM 57 615557
Disease Ontology 12 DOID:5052
ICD9CM 35 025
MeSH 44 D008554
Orphanet 59 ORPHA31202
MESH via Orphanet 45 D008554
ICD10 via Orphanet 34 A24.1 A24.2 A24.3 more
UMLS via Orphanet 74 C0025229

Summaries for Melioidosis

NIH Rare Diseases : 53 Melioidosis is an infectious disease caused by the bacteriaBurkholderia pseudomallei that are commonly found in the soil and water. Melioidosis is a rare disease in the United States, but it is common in tropical or subtropical areas of the world, including Southeast Asia, Africa, and Australia. The signs and symptoms of the disease can vary greatly and may mimic those of tuberculosis or common forms of pneumonia. Signs and symptoms may include pain or swelling, fever, abscess, cough, high fever, headache, trouble breathing, and more. Although healthy people can also experience signs and symptoms of the disease, people with certain conditions like diabetes, liver disease, kidney disease, lung disease, thalassemia, cancer, or certain autoimmune diseases are more severely affected. Diagnosis is made by collecting blood, sputum, urine, or pus samples and growing the bacteria. Current treatment is divided into two stages: an intravenous (IV) antibiotic stage and oral antibiotic maintenance stage to prevent recurrence.

MalaCards based summary : Melioidosis, also known as melioidosis, susceptibility to, is related to septic arthritis and osteomyelitis, and has symptoms including fever, respiratory distress and chest pain. An important gene associated with Melioidosis is TLR5 (Toll Like Receptor 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Sulfamethoxazole and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and bone, and related phenotypes are Decreased viability in esophageal squamous lineage and hematopoietic system

OMIM : 57 Melioidosis is infection caused by the gram-negative, flagellated soil saprophyte Burkholderia pseudomallei, which is endemic in parts of southeast Asia and northern Australia. Sepsis is a common clinical presentation of disease, and lung is the organ most commonly involved. In northern Thailand, where B. pseudomallei is the most common bloodstream isolate, the overall melioidosis mortality rate exceeds 40%, and pneumonia confers more than 2-fold increased risk of death (summary by West et al., 2013). (615557)

CDC : 3 Melioidosis, also called Whitmore's disease, is an infectious disease that can infect humans or animals. The disease is caused by the bacterium Burkholderia pseudomallei.

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, has material basis in Burkholderia pseudomallei, which is transmitted by contact with the contaminated water or soil. The infection has symptom fever, has symptom respiratory distress, has symptom chest pain, and has symptom stomach pain.

Wikipedia : 76 Melioidosis is an infectious disease caused by a Gram-negative bacterium, Burkholderia pseudomallei,... more...

Related Diseases for Melioidosis

Diseases related to Melioidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 297)
# Related Disease Score Top Affiliating Genes
1 septic arthritis 30.2 IFNG TLR2 TLR4 TLR5
2 osteomyelitis 30.0 IFNG IL6 TNF
3 prostatitis 29.7 IL10 IL6 TNF
4 fasciitis 29.7 IL18 IL6 TNF
5 acute cholangitis 29.6 IL6 TREM1
6 laryngitis 29.5 IL6 TNF
7 penicilliosis 29.4 TLR1 TLR2 TLR4 TNF
8 cutaneous leishmaniasis 29.3 IFNG IL10 TLR2 TNF
9 transverse myelitis 29.3 IL10 IL6 TNF
10 leptospirosis 29.2 IL10 IL6 TLR2 TNF
11 leishmaniasis 29.0 IFNG IL10 TLR2 TLR4 TNF
12 pulmonary tuberculosis 29.0 IFNG IL10 IL18 TLR2 TNF
13 lymphadenitis 28.9 IFNG IL10 IL18 TLR4 TNF
14 endocarditis 28.9 IL10 IL6 TLR2 TNF
15 peritonitis 28.9 IL10 IL6 TLR2 TNF
16 bronchiolitis obliterans 28.9 IFNG IL10 IL6 TNF
17 arthritis 28.8 IFNG IL10 IL18 IL6 TNF
18 pyelonephritis 28.8 IL10 IL6 TLR4 TNF
19 brucellosis 28.6 IFNG IL10 IL6 TLR4 TNF
20 meningitis 28.2 IFNG IL10 IL6 TLR2 TNF
21 systemic lupus erythematosus 27.8 IFNG IL10 IL18 IL6 TLR5 TNF
22 pneumonia 27.8 IL10 IL6 TLR2 TLR4 TLR5 TNF
23 q fever 27.1 IFNG IL10 TLR1 TLR10 TLR2 TLR4
24 bronchiolitis 26.4 IFNG IL10 IL6 TLR1 TLR10 TLR4
25 variola major 10.9 IFNG TLR4
26 hyperlucent lung 10.8 IFNG IL10
27 glanders 10.7
28 ocular toxoplasmosis 10.7 TLR1 TLR5
29 prosthetic joint infection 10.7 TLR2 TLR4
30 staphylococcal toxic shock syndrome 10.7 IFNG TNF
31 pouchitis 10.7 IL10 TLR4
32 sporotrichosis 10.7 IFNG IL10
33 autoimmune myocarditis 10.7 IFNG TNF
34 punctate inner choroidopathy 10.7 IL10 TNF
35 baylisascariasis 10.6 IFNG IL10
36 tropical endomyocardial fibrosis 10.6 IL10 TNF
37 spondylarthropathy 10.6 TLR4 TNF
38 systemic onset juvenile idiopathic arthritis 10.6 IL18 TNF
39 trichosporonosis 10.6 IFNG TNF
40 necrotizing ulcerative gingivitis 10.6 IL10 IL18
41 chronic beryllium disease 10.6 IFNG TNF
42 campylobacteriosis 10.6 IFNG TLR4
43 microscopic polyangiitis 10.6 IL10 TNF
44 multifocal choroiditis 10.6 IL10 TNF
45 tungiasis 10.6 IL10 TNF
46 endomyocardial fibrosis 10.6 IL10 TNF
47 transient hypogammaglobulinemia 10.5 IL10 TNF
48 cow milk allergy 10.5 IL10 IL18
49 acute cervicitis 10.5 TLR2 TLR4
50 suppurative otitis media 10.5 TLR2 TLR4 TLR5

Graphical network of the top 20 diseases related to Melioidosis:



Diseases related to Melioidosis

Symptoms & Phenotypes for Melioidosis

Clinical features from OMIM:

615557

Symptoms:

12
  • fever
  • respiratory distress
  • chest pain
  • stomach pain

GenomeRNAi Phenotypes related to Melioidosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.23 IL18 IL6 IRAK3 LY96 TLR1 TLR4

MGI Mouse Phenotypes related to Melioidosis:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.23 TLR4 IRAK3 TREM1 IL18 LY96 IFNG
2 immune system MP:0005387 10.18 TLR4 IRAK3 TREM1 IL18 LY96 IFNG
3 cardiovascular system MP:0005385 10.13 IL6 TNF IL10 TLR4 IL18 TLR5
4 growth/size/body region MP:0005378 10.13 TLR2 IL6 TNF IL10 IRAK3 TLR4
5 homeostasis/metabolism MP:0005376 10.13 IL6 TNF IL10 IRAK3 TLR4 IL18
6 digestive/alimentary MP:0005381 10.11 IL10 TLR4 IL18 IFNG TLR5 TLR2
7 endocrine/exocrine gland MP:0005379 10.04 TLR2 IL6 TNF IL10 IRAK3 TLR5
8 adipose tissue MP:0005375 10.01 IL6 TNF TLR4 IL18 TLR5 TLR2
9 integument MP:0010771 9.91 IL6 TNF IL10 TLR4 IL18 IFNG
10 liver/biliary system MP:0005370 9.87 TNF IL10 TLR4 IFNG TLR5 TLR2
11 muscle MP:0005369 9.8 TNF IL10 TLR4 IL18 IFNG TLR2
12 neoplasm MP:0002006 9.7 TNF IL10 TLR4 IFNG TLR2 IL6
13 respiratory system MP:0005388 9.5 TNF IL10 TLR4 IFNG TLR5 TLR2
14 skeleton MP:0005390 9.23 TNF IL10 IRAK3 TLR4 IFNG TLR2

Drugs & Therapeutics for Melioidosis

Drugs for Melioidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sulfamethoxazole Approved Phase 4 723-46-6 5329
2
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
3 Anti-Bacterial Agents Phase 4,Not Applicable
4 Anti-Infective Agents Phase 4,Not Applicable
5 Renal Agents Phase 4
6 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
7 Antiparasitic Agents Phase 4
8 Antiprotozoal Agents Phase 4
9 Antimalarials Phase 4
10
Meropenem Approved, Investigational Not Applicable 119478-56-7 64778 441130
11
Ceftazidime Approved Not Applicable 78439-06-2, 72558-82-8 5481173
12 Thienamycins Not Applicable
13 Pharmaceutical Solutions Not Applicable
14 Antibodies Not Applicable
15 Immunoglobulins Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Co-trimoxazole as Maintenance Therapy for Meliodosis Active, not recruiting NCT01420341 Phase 4 Co-trimoxazole 12;Co-trimoxazole 20
2 A Randomized Double Blinded Comparison of Ceftazidime and Meropenem in Severe Melioidosis Unknown status NCT00579956 Not Applicable Meropenem;Ceftazidime
3 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830 Not Applicable
4 A Single-blind Stepped Wedge Cluster Randomized Controlled Behaviour Change Trial to Determine Effectiveness of Prevention Programme of Melioidosis in Diabetics in Ubon Ratchathani, Northeast Thailand Recruiting NCT02089152 Not Applicable
5 Clinical Presentation of Melioidosis in Head and Neck Region Recruiting NCT03048513
6 Study to Obtain Blood and Voided Urine Samples to Improve the Diagnosis of Melioidosis Recruiting NCT02668406
7 Adapting LFI for Melioidosis Recruiting NCT03528265
8 Causes of Pneumonia in Yangon Not yet recruiting NCT03578133

Search NIH Clinical Center for Melioidosis

Cochrane evidence based reviews: melioidosis

Genetic Tests for Melioidosis

Genetic tests related to Melioidosis:

# Genetic test Affiliating Genes
1 Melioidosis, Susceptibility to 29 TLR5

Anatomical Context for Melioidosis

MalaCards organs/tissues related to Melioidosis:

41
Lung, Liver, Bone, Skin, Kidney, Testes, T Cells

Publications for Melioidosis

Articles related to Melioidosis:

(show top 50) (show all 713)
# Title Authors Year
1
Melioidosis: the great mimicker presenting as spondylodiscitis. ( 29437812 )
2018
2
Hospitalized Bacteremic Melioidosis in Rural Thailand: 2009-2013. ( 29611505 )
2018
3
Neurological melioidosis (Burkholderia pseudomallei) in a chronic psychotic patient treated with antipsychotics: A case report. ( 29901631 )
2018
4
Melioidosis: a neglected tropical disease ( 29754477 )
2018
5
Imported melioidosis in Japan: a review of cases. ( 29416361 )
2018
6
A rapid immunochromatography test based on Hcp1 is a potential point-of-care test for serological diagnosis of melioidosis. ( 29848565 )
2018
7
Pulmonary Delivery of Ceftazidime for the Treatment of Melioidosis in a Murine Model. ( 29363975 )
2018
8
Melioidosis. ( 29388564 )
2018
9
Retrospective Analysis of Fever and Sepsis Patients from Cambodia Reveals Serological Evidence of Melioidosis. ( 29436341 )
2018
10
A Case of Constrictive Pericarditis Associated with Melioidosis in an Immunocompetent Patient Treated by Pericardiectomy. ( 29551765 )
2018
11
Clinical, Bacteriologic, and Geographic Stratification of Melioidosis Emerges from the Sri Lankan National Surveillance Program. ( 29313474 )
2018
12
Ocular involvement in melioidosis: a 23-year retrospective review. ( 29589220 )
2018
13
Performance evaluation of Active Melioidosis Detect-Lateral Flow Assay (AMD-LFA) for diagnosis of melioidosis in endemic settings with limited resources. ( 29579128 )
2018
14
Melioidosis in Mexico, Central America, and the Caribbean. ( 29780897 )
2018
15
Melioidosis in Thailand: Present and Future. ( 29725623 )
2018
16
Gastrointestinal: Splenic abscesses-related gastrosplenic fistula: Unusual complication of melioidosis. ( 29603361 )
2018
17
Genitourinary melioidosis in a Bangladeshi farmer with IgA nephropathy complicated by steroid-induced diabetes mellitus. ( 29970750 )
2018
18
Trimethoprim+Sulfamethoxazole Reduces Rates of Melioidosis in High-Risk Hemodialysis Patients. ( 29340327 )
2018
19
Epidemiological and Clinical Features of Melioidosis: A Report of Seven Cases from Southern Inland China. ( 29611506 )
2018
20
Isolated septic arthritis of hip joint: a rare presentation of melioidosis. A case report. ( 29351806 )
2018
21
VALIDATE: Exploiting the synergy between complex intracellular pathogens to expedite vaccine research and development for tuberculosis, leishmaniasis, melioidosis and leprosy. ( 29904595 )
2018
22
Developing Inclusivity and Exclusivity Panels for Testing Diagnostic and Detection Tools Targeting <i>Burkholderia pseudomallei</i>, the Causative Agent of Melioidosis. ( 29678218 )
2018
23
Melioidosis, Singapore, 2003-2014. ( 29260679 )
2018
24
Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18. ( 29791511 )
2018
25
Melioidosis: a neglected tropical disease ( 29724090 )
2018
26
De novo subgaleal abscess - a rare presentation of melioidosis: aA case report. ( 29706135 )
2018
27
Clinical features and outcome of patients with cutaneous melioidosis during a nosocomial outbreak in a temperate region of Australia. ( 29623994 )
2018
28
Soil characteristics influencing the spatial distribution of melioidosis in Far North Queensland, Australia. ( 29970213 )
2018
29
Pulmonary melioidosis with laryngeal involvement: an unusual site of infection. ( 29374089 )
2018
30
Splenic granuloma: Melioidosis or Tuberculosis? ( 29915776 )
2018
31
Public health response to an imported case of canine melioidosis. ( 29451368 )
2018
32
Cutaneous melioidosis: two cases of chronic primary forms. ( 29356200 )
2018
33
Virulence of the melioidosis pathogen<i>Burkholderia pseudomallei</i>requires the oxidoreductase membrane protein DsbB. ( 29440370 )
2018
34
Melioidosis. ( 29388572 )
2018
35
Septicemic Melioidosis with Ruptured Splenic Abscess in a Patient with Thalassemia Intermedia. ( 28250624 )
2017
36
DNA vaccination resurfaces in the struggle against melioidosis. ( 28481716 )
2017
37
Gastrointestinal manifestations of melioidosis: A single center experience. ( 28353081 )
2017
38
Pediatric melioidosis in Sarawak, Malaysia: Epidemiological, clinical and microbiological characteristics. ( 28599008 )
2017
39
Children with melioidosis in Far North Queensland are commonly bacteraemic and have a high case fatality rate. ( 29864385 )
2017
40
Gastrointestinal tract involvement in melioidosis. ( 28673019 )
2017
41
The epidemiology and clinical features of melioidosis in Far North Queensland: Implications for patient management. ( 28264029 )
2017
42
A simple laboratory algorithm for diagnosis of melioidosis in resource-constrained areas: a study from north-central Vietnam. ( 28780059 )
2017
43
Acute disseminated melioidosis giving rise to pneumonia and renal abscesses complicated with thrombotic thrombocytopenic purpura in a post partum woman: a case report. ( 29187254 )
2017
44
Anion inhibition profiles of the I^-carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei responsible of melioidosis and highly drug resistant to common antibiotics. ( 27914949 )
2017
45
Calprotectin as a Biomarker for Melioidosis Disease Progression and Management. ( 28179407 )
2017
46
Melioidosis with possible Haemophagocytic lymphohistiocytosis. ( 28571052 )
2017
47
Type III Secretion in the Melioidosis Pathogen Burkholderia pseudomallei. ( 28664152 )
2017
48
Imported Case of Melioidosis in Oman: Case Report. ( 28042405 )
2017
49
Cavitary lung lesions: Melioidosis and pulmonary embolism causing necrotizing pneumonia. ( 28791214 )
2017
50
Non-healing chest wall ulcer caused by cutaneous melioidosis. ( 28232013 )
2017

Variations for Melioidosis

Expression for Melioidosis

LifeMap Discovery
Genes differentially expressed in tissues of Melioidosis patients vs. healthy controls: 35 (show top 50) (show all 181)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 CD177 CD177 molecule Blood + 8.41 0.000
2 ZDHHC19 zinc finger, DHHC-type containing 19 Blood + 6.91 0.000
3 MMP8 matrix metallopeptidase 8 Blood + 6.49 0.000
4 SLC51A solute carrier family 51, alpha subunit Blood + 6.46 0.000
5 HP haptoglobin Blood + 6.23 0.000
6 FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide Blood - 6.00 0.000
7 GPR84 G protein-coupled receptor 84 Blood + 5.86 0.000
8 ANKRD22 ankyrin repeat domain 22 Blood + 5.72 0.000
9 OLAH oleoyl-ACP hydrolase Blood + 5.54 0.000
10 LRRN3 leucine rich repeat neuronal 3 Blood - 5.51 0.000
11 PCOLCE2 procollagen C-endopeptidase enhancer 2 Blood + 5.47 0.000
12 C1QC complement component 1, q subcomponent, C chain Blood + 5.42 0.000
13 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Blood + 5.39 0.000
14 CCNA1 cyclin A1 Blood + 5.14 0.000
15 C1QB complement component 1, q subcomponent, B chain Blood + 5.09 0.000
16 LINC00668 long intergenic non-protein coding RNA 668 Blood + 4.99 0.000
17 CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit Blood + 4.98 0.000
18 FGF13 fibroblast growth factor 13 Blood + 4.96 0.000
19 NOV nephroblastoma overexpressed Blood - 4.84 0.000
20 PLVAP plasmalemma vesicle associated protein Blood - 4.76 0.000
21 KL klotho Blood + 4.74 0.000
22 SLCO4A1 solute carrier organic anion transporter family, member 4A1 Blood + 4.73 0.000
23 MYO10 myosin X Blood + 4.68 0.000
24 SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 Blood + 4.68 0.000
25 RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 Blood - 4.67 0.000
26 RETN resistin Blood + 4.65 0.000
27 CD274 CD274 molecule Blood + 4.44 0.000
28 MCEMP1 mast cell-expressed membrane protein 1 Blood + 4.44 0.000
29 BMX BMX non-receptor tyrosine kinase Blood + 4.41 0.000
30 SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 Blood + 4.38 0.000
31 CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) Blood + 4.38 0.000
32 GRB10 growth factor receptor-bound protein 10 Blood + 4.37 0.000
33 CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 Blood - 4.25 0.000
34 LINC01220 long intergenic non-protein coding RNA 1220 Blood + 4.20 0.000
35 LTF lactotransferrin Blood + 4.19 0.000
36 SLC26A8 solute carrier family 26 (anion exchanger), member 8 Blood + 4.18 0.000
37 ARG1 arginase 1 Blood + 4.17 0.000
38 IL18R1 interleukin 18 receptor 1 Blood + 4.17 0.000
39 IL1R2 interleukin 1 receptor, type II Blood + 4.08 0.000
40 SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 Blood + 4.06 0.000
41 CFH complement factor H Blood + 4.03 0.000
42 G0S2 G0/G1 switch 2 Blood + 4.02 0.000
43 MMP9 matrix metallopeptidase 9 Blood + 3.97 0.000
44 FCAR Fc fragment of IgA receptor Blood + 3.94 0.000
45 SCN9A sodium channel, voltage gated, type IX alpha subunit Blood + 3.94 0.000
46 FAM20A family with sequence similarity 20, member A Blood + 3.94 0.000
47 KRTAP19-6 keratin associated protein 19-6 Blood + 3.93 0.000
48 TDRD9 tudor domain containing 9 Blood + 3.92 0.000
49 KREMEN1 kringle containing transmembrane protein 1 Blood + 3.86 0.000
50 HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 Blood + 3.84 0.000
Search GEO for disease gene expression data for Melioidosis.

Pathways for Melioidosis

Pathways related to Melioidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 IFNG IL10 IL18 IL6 IRAK3 LY96
2
Show member pathways
13.61 IFNG IL10 IL18 IL6 LY96 TLR4
3
Show member pathways
13.54 IRAK3 LY96 TLR1 TLR10 TLR2 TLR4
4
Show member pathways
13.43 IL10 IL18 IL6 IRAK3 TLR1 TLR10
5
Show member pathways
13.31 IFNG IL10 IL18 IL6 IRAK3 TNF
6
Show member pathways
12.85 IFNG IL10 IL18 IL6 TNF
7
Show member pathways
12.84 IFNG IL18 IL6 TLR2 TLR4 TNF
8
Show member pathways
12.82 IFNG IL10 IL18 IL6 IRAK3 LY96
9
Show member pathways
12.81 IFNG IL18 IL6 LY96 TLR4 TNF
10
Show member pathways
12.81 IFNG IRAK3 TLR1 TLR10 TLR2 TLR4
11
Show member pathways
12.76 IL6 IRAK3 TLR1 TLR10 TLR2 TLR4
12
Show member pathways
12.67 IFNG IL10 IL18 IL6 TNF
13 12.64 IFNG IL10 IRAK3 TLR1 TLR2 TNF
14
Show member pathways
12.62 IFNG IL10 IL18 IL6 TNF
15
Show member pathways
12.57 IRAK3 TLR1 TLR10 TLR2 TLR4 TLR5
16
Show member pathways
12.54 IL6 TLR2 TLR4 TNF
17
Show member pathways
12.49 IRAK3 LY96 TLR1 TLR10 TLR2 TLR4
18
Show member pathways
12.46 IFNG IL10 IL18 IL6 TLR2 TLR4
19
Show member pathways
12.45 LY96 TLR1 TLR2 TLR4
20
Show member pathways
12.41 IFNG IL10 IL6 TNF
21
Show member pathways
12.4 IFNG IL6 TLR2 TLR5 TNF
22
Show member pathways
12.37 IFNG IL6 IRAK3 LY96 TLR4 TNF
23
Show member pathways
12.35 IFNG IL10 LY96 TLR2 TLR4 TNF
24
Show member pathways
12.3 IL18 IL6 TLR2 TLR5 TNF
25 12.26 IFNG IL10 IL18 IL6 TLR1 TLR2
26 12.19 IFNG IL6 TLR1 TLR10 TLR2 TLR4
27
Show member pathways
12.19 IL6 IRAK3 LY96 TLR1 TLR10 TLR2
28
Show member pathways
12.13 TLR1 TLR10 TLR2 TLR4 TLR5
29 12.07 IFNG IL6 TLR4 TNF
30 12.05 IFNG IL10 IL6 TNF
31
Show member pathways
12.04 IFNG IL10 IL18 IL6
32 12.04 IL10 IL18 IL6 TNF
33 11.98 IFNG IL10 IL6 TLR2 TLR4 TNF
34 11.95 IFNG IL18 IL6 TLR4 TLR5
35 11.94 TLR1 TLR10 TLR2 TLR4 TLR5
36 11.94 IFNG IL18 IL6 TLR2 TLR4 TNF
37
Show member pathways
11.93 IFNG IL10 IL18 IL6 TLR1 TLR10
38 11.89 IFNG IL6 TLR4
39 11.88 IFNG IL10 IL18 TNF
40 11.88 IL10 IL6 LY96 TLR4 TNF
41 11.87 LY96 TLR4 TNF
42 11.85 IFNG IL10 IL6
43
Show member pathways
11.85 IL6 LY96 TLR4
44 11.83 IFNG IL10 IL6 TNF
45 11.73 LY96 TLR4 TNF
46 11.69 IRAK3 LY96 TLR4 TNF
47
Show member pathways
11.67 IFNG IL6 TNF
48 11.67 IL18 IL6 TLR2 TLR4 TLR5 TNF
49 11.64 IL10 IL18 IL6 TNF
50 11.64 IFNG IL18 TLR2 TLR4 TNF

GO Terms for Melioidosis

Cellular components related to Melioidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide receptor complex GO:0046696 9.16 LY96 TLR4
2 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.96 TLR1 TLR2
3 intrinsic component of plasma membrane GO:0031226 8.8 LY96 TLR2 TLR4

Biological processes related to Melioidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.99 IL10 TLR1 TLR4 TLR5 TNF
2 response to lipopolysaccharide GO:0032496 9.97 IL10 IRAK3 LY96 TLR2 TLR4
3 immune response GO:0006955 9.97 IFNG IL10 IL18 IL6 TLR1 TLR10
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.92 IL6 IRAK3 TLR2 TLR4 TNF
5 positive regulation of DNA binding transcription factor activity GO:0051091 9.91 IL10 IL6 TNF
6 response to virus GO:0009615 9.91 IFNG IRAK3 TNF
7 defense response to Gram-positive bacterium GO:0050830 9.9 IL6 TLR2 TNF
8 apoptotic signaling pathway GO:0097190 9.88 LY96 TLR4 TNF
9 positive regulation of inflammatory response GO:0050729 9.88 IL18 TLR10 TLR2 TLR4
10 cellular response to lipopolysaccharide GO:0071222 9.88 IL10 IL6 LY96 TLR4 TLR5 TNF
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.87 IFNG IL18 IL6
12 response to glucocorticoid GO:0051384 9.86 IL10 IL6 TNF
13 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.86 LY96 TLR4 TNF
14 humoral immune response GO:0006959 9.86 IFNG IL6 TNF TREM1
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.85 IL18 IL6 TNF
16 positive regulation of interleukin-6 production GO:0032755 9.85 IL6 TLR2 TLR4 TNF
17 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.84 IL18 TLR2 TLR4 TNF
18 positive regulation of tumor necrosis factor production GO:0032760 9.83 LY96 TLR2 TLR4
19 positive regulation of interferon-gamma production GO:0032729 9.83 IL18 TLR4 TNF
20 negative regulation of tumor necrosis factor production GO:0032720 9.82 IL10 IRAK3 TLR4
21 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 IFNG TLR4 TLR5 TNF
22 positive regulation of interleukin-12 production GO:0032735 9.78 IFNG TLR2 TLR4
23 positive regulation of interleukin-8 production GO:0032757 9.78 TLR2 TLR4 TLR5 TNF
24 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 IL18 LY96 TLR2 TLR4 TNF
25 negative regulation of interleukin-6 production GO:0032715 9.76 IL10 IRAK3 TLR4 TNF
26 negative regulation of myoblast differentiation GO:0045662 9.75 IL18 TNF
27 positive regulation of osteoclast differentiation GO:0045672 9.75 IFNG TNF
28 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.75 LY96 TLR4
29 cell activation GO:0001775 9.75 TLR1 TLR2
30 necroptotic process GO:0070266 9.74 LY96 TLR4
31 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.74 IFNG TNF
32 positive regulation of macrophage activation GO:0043032 9.74 IL10 TLR4
33 toll-like receptor 4 signaling pathway GO:0034142 9.74 LY96 TLR4
34 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.74 TLR2 TLR4
35 negative regulation of growth of symbiont in host GO:0044130 9.74 IL10 TNF
36 positive regulation of interleukin-8 secretion GO:2000484 9.74 TLR1 TLR2
37 response to molecule of bacterial origin GO:0002237 9.73 IL10 TLR2
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.73 IL10 TNF
39 interferon-gamma production GO:0032609 9.73 IL18 TLR4
40 positive regulation of chemokine production GO:0032722 9.73 IL6 TLR2 TLR4 TNF
41 toll-like receptor signaling pathway GO:0002224 9.73 IRAK3 LY96 TLR1 TLR10 TLR2 TLR4
42 negative regulation of interleukin-12 production GO:0032695 9.72 IL10 IRAK3
43 I-kappaB phosphorylation GO:0007252 9.72 TLR2 TLR4
44 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.72 TLR1 TLR4
45 cellular response to lipoteichoic acid GO:0071223 9.72 TLR2 TLR4
46 negative regulation of interleukin-17 production GO:0032700 9.72 IFNG TLR4
47 T-helper 1 type immune response GO:0042088 9.71 IL18 TLR4
48 macrophage activation GO:0042116 9.71 TLR1 TLR4
49 negative regulation of lipid storage GO:0010888 9.71 IL6 TNF
50 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.7 TLR4 TNF

Molecular functions related to Melioidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.62 TLR1 TLR10 TLR4 TLR5
2 signaling receptor activity GO:0038023 9.46 TLR1 TLR2 TLR4 TREM1
3 cytokine activity GO:0005125 9.35 IFNG IL10 IL18 IL6 TNF
4 lipopeptide binding GO:0071723 9.26 TLR1 TLR2
5 lipopolysaccharide receptor activity GO:0001875 8.8 LY96 TLR2 TLR4

Sources for Melioidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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