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MCID: MLD001
MIFTS: 67

Melioidosis

Categories: Genetic diseases, Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Melioidosis

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MalaCards integrated aliases for Melioidosis:

Name: Melioidosis 57 12 74 20 58 54 3 44 15 71
Melioidosis, Susceptibility to 57 29 39
Burkholderia Pseudomallei Infection 20 3
Acute and Fulminating Melioidosis 12 32
Subacute and Chronic Melioidosis 12 32
Nightcliff Gardener's Disease 12 20
B Pseudomallei Infection 20
Epizootic Lymphangitis 71
Whitmore's Disease 12
Whitmore Disease 20
Pseudoglanders 12

Characteristics:

Orphanet epidemiological data:

58
melioidosis
Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:5052
OMIM® 57 615557
ICD9CM 34 025
MeSH 44 D008554
NCIt 50 C128336
SNOMED-CT 67 428111003
MESH via Orphanet 45 D008554
ICD10 via Orphanet 33 A24.1 A24.2 A24.3 more
UMLS via Orphanet 72 C0025229
Orphanet 58 ORPHA31202
UMLS 71 C0025229 C1998095
Sources

Summaries for Melioidosis

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GARD : 20 Melioidosis is an infectious disease caused by the bacteria Burkholderia pseudomallei that are commonly found in the soil and water. Melioidosis is a rare disease in the United States, but it is common in tropical or subtropical areas of the world, including Southeast Asia, Africa, and Australia. The signs and symptoms of the disease can vary greatly and may mimic those of tuberculosis or common forms of pneumonia. Signs and symptoms may include pain or swelling, fever, abscess, cough, high fever, headache, trouble breathing, and more. Although healthy people can also experience signs and symptoms of the disease, people with certain conditions like diabetes, liver disease, kidney disease, lung disease, thalassemia, cancer, or certain autoimmune diseases are more severely affected. Diagnosis is made by collecting blood, sputum, urine, or pus samples and growing the bacteria. Current treatment is divided into two stages: an intravenous (IV) antibiotic stage and oral antibiotic maintenance stage to prevent recurrence.

MalaCards based summary : Melioidosis, also known as melioidosis, susceptibility to, is related to septic arthritis and cellulitis, and has symptoms including fever, chest pain and respiratory distress. An important gene associated with Melioidosis is TLR5 (Toll Like Receptor 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Sulfamethoxazole and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and lung, and related phenotypes are fever and sepsis

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, has material basis in Burkholderia pseudomallei, which is transmitted by contact with the contaminated water or soil. The infection has symptom fever, has symptom respiratory distress, has symptom chest pain, and has symptom stomach pain.

OMIM® : 57 Melioidosis is infection caused by the gram-negative, flagellated soil saprophyte Burkholderia pseudomallei, which is endemic in parts of southeast Asia and northern Australia. Sepsis is a common clinical presentation of disease, and lung is the organ most commonly involved. In northern Thailand, where B. pseudomallei is the most common bloodstream isolate, the overall melioidosis mortality rate exceeds 40%, and pneumonia confers more than 2-fold increased risk of death (summary by West et al., 2013). (615557) (Updated 05-Mar-2021)

CDC : 3 Melioidosis, also called Whitmore's disease, is an infectious disease that can infect humans or animals. The disease is caused by the bacterium Burkholderia pseudomallei. It is predominately a disease of tropical climates, especially in Southeast Asia and northern Australia where it is widespread. The bacteria causing melioidosis are found in contaminated water and soil. It is spread to humans and animals through direct contact with the contaminated source.

Wikipedia : 74 Melioidosis is an infectious disease caused by a Gram-negative bacterium called Burkholderia... more...

Sources

Related Diseases for Melioidosis

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Diseases related to Melioidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 642)
# Related Disease Score Top Affiliating Genes
1 septic arthritis 30.9 TREM1 TLR5 TLR4 TLR2 IFNG
2 cellulitis 30.8 TNF IL6 CSF3
3 pericarditis 30.6 TNF IL6 IFNG
4 meningoencephalitis 30.6 TNF IL6 IL10
5 tularemia 30.6 TNF TLR4 TLR2
6 disease by infectious agent 30.5 TNF TLR4 TLR2 NOD2 LY96 IL6
7 lung abscess 30.5 TNF IL6 IFNG
8 bronchopneumonia 30.5 TNF TLR4 IL6 IL10
9 prostatitis 30.4 TNF IL6 IL10
10 fasciitis 30.4 TNF IL6 IL18 IFNG
11 endocarditis 30.3 TNF TLR2 IL6 IL10 IFNG
12 osteomyelitis 30.3 TNF TLR4 TLR2 NOD2 IL6 IL10
13 myelitis 30.3 TNF IL6 IL10
14 endophthalmitis 30.2 TNF TLR2 IL6
15 toxic shock syndrome 30.2 TREM1 TNF TLR4 TLR2 IL6 IL10
16 infective endocarditis 30.2 TREM1 TNF TLR2 IL6
17 plague 30.2 TNF TLR4 TLR2 IL6 IL10
18 chorioamnionitis 30.2 TREM1 TNF TLR4 IL6 IL18 IL10
19 chronic kidney disease 30.2 TNF TLR4 IL6 IL18 IL10
20 lymphadenitis 30.1 TNF TLR4 NOD2 IL18 IL10 IFNG
21 pulmonary tuberculosis 30.1 TNF TLR2 IL6 IL18 IL10 IFNG
22 leptospirosis 30.1 TNF TLR2 TLR1 IL6 IL18 IL10
23 typhoid fever 30.1 TNF TLR5 TLR4 IL6 IFNG
24 suppurative otitis media 30.1 TLR5 TLR4 TLR2
25 encephalitis 30.1 TNF TLR2 IL6 IL10 CXCL9
26 dengue hemorrhagic fever 30.1 TNF IL6 IL10 IFNG
27 tetanus 30.0 TNF IL6 IL10 IFNG
28 miliary tuberculosis 30.0 TNF IFNG CSF3
29 orchitis 30.0 TNF IL6 IL10
30 endometritis 30.0 TNF TLR4 IL6
31 transverse myelitis 30.0 TNF IL6 IL10
32 dengue disease 30.0 TNF IL10 IFNG
33 neutropenia 30.0 TNF TLR4 IL6 IL10 IFNG CSF3
34 gastrointestinal tuberculosis 29.9 TNF NOD2 IFNG
35 spinal cord disease 29.9 TNF IL6 IL10
36 panniculitis 29.9 TNF IFNG CSF3
37 acquired immunodeficiency syndrome 29.9 TNF IL6 IL15 IL10 IFNG
38 extrapulmonary tuberculosis 29.9 TLR2 IL10 IFNG CXCL9
39 nocardiosis 29.9 TNF IFNG
40 pyelonephritis 29.9 TNF TLR4 IL6 IL10 IFNG CSF3
41 adult-onset still's disease 29.9 TNF IL6 IL18 IFNG
42 hemophagocytic lymphohistiocytosis 29.9 TNF IL18 IL10 IFNG
43 alcoholic liver cirrhosis 29.9 TNF TLR4 IL6 IL10
44 cystic fibrosis 29.9 TNF TLR5 TLR4 TLR2 IL6 IL10
45 rheumatic heart disease 29.9 TNF TLR2 IL6 IL10
46 purpura 29.9 TNF IL6 IL10 IFNG
47 exanthem 29.8 TNF IL6 IL18 IL10 IFNG CSF3
48 aseptic meningitis 29.8 TNF IL10 IFNG CSF3
49 cholangitis 29.8 TNF TLR4 NOD2 IL6 IL10
50 erythema nodosum 29.8 TNF NOD2 IL6 IL10 IFNG

Graphical network of the top 20 diseases related to Melioidosis:



Diseases related to Melioidosis
Sources

Symptoms & Phenotypes for Melioidosis

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Human phenotypes related to Melioidosis:

58 31 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
2 sepsis 58 31 frequent (33%) Frequent (79-30%) HP:0100806
3 pneumonia 58 31 frequent (33%) Frequent (79-30%) HP:0002090
4 acute infectious pneumonia 58 31 frequent (33%) Frequent (79-30%) HP:0011949
5 shock 58 31 frequent (33%) Frequent (79-30%) HP:0031273
6 lung abscess 58 31 frequent (33%) Frequent (79-30%) HP:0025044
7 bacteremia 58 31 frequent (33%) Frequent (79-30%) HP:0031864
8 hepatitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012115
9 cellulitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100658
10 osteoarthritis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002758
11 liver abscess 58 31 occasional (7.5%) Occasional (29-5%) HP:0100523
12 septic arthritis 58 31 occasional (7.5%) Occasional (29-5%) HP:0003095
13 brain abscess 58 31 occasional (7.5%) Occasional (29-5%) HP:0030049
14 splenic abscess 58 31 occasional (7.5%) Occasional (29-5%) HP:0025059
15 cutaneous abscess 58 31 occasional (7.5%) Occasional (29-5%) HP:0031292
16 unusual skin infection 58 31 occasional (7.5%) Occasional (29-5%) HP:0032162
17 prostatitis 58 31 very rare (1%) Very rare (<4-1%) HP:0000024
18 parotitis 58 31 very rare (1%) Very rare (<4-1%) HP:0011850
19 foot osteomyelitis 58 31 very rare (1%) Very rare (<4-1%) HP:0001886
20 abnormality of the spleen 58 Occasional (29-5%)
21 abnormality of the genitourinary system 58 Very rare (<4-1%)
22 respiratory tract infection 58 Frequent (79-30%)
23 abnormal parotid gland morphology 58 Very rare (<4-1%)

Clinical features from OMIM®:

615557 (Updated 05-Mar-2021)

Symptoms:

12
  • • fever
  • • chest pain
  • • respiratory distress
  • • stomach pain

MGI Mouse Phenotypes related to Melioidosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.3 CD14 CSF3 IFNG IL10 IL15 IL18
2 immune system MP:0005387 10.19 CD14 CSF3 IFNG IL10 IL15 IL18
3 homeostasis/metabolism MP:0005376 10.17 CD14 IFNG IL10 IL18 IL6 IRAK3
4 digestive/alimentary MP:0005381 10.06 IFNG IL10 IL18 IL6 NOD2 TLR2
5 neoplasm MP:0002006 9.7 IFNG IL10 IL6 TLR2 TLR4 TNF
6 respiratory system MP:0005388 9.56 CD14 IFNG IL10 IL6 TLR2 TLR4
7 skeleton MP:0005390 9.32 CD14 IFNG IL10 IL6 IRAK3 NBR1
Sources

Drugs & Therapeutics for Melioidosis

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Drugs for Melioidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sulfamethoxazole Approved Phase 4 723-46-6 5329
2
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
3 Anti-Infective Agents Phase 4
4 Anti-Bacterial Agents Phase 4
5 Antiparasitic Agents Phase 4
6 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
7 Antiprotozoal Agents Phase 4
8 Antimalarials Phase 4
9
Meropenem Approved, Investigational 96036-03-2, 119478-56-7 64778 441130
10
Ceftazidime Approved 72558-82-8, 78439-06-2 5481173
11 Pharmaceutical Solutions
12 Immunologic Factors
13 Immunoglobulin G
14 Immunoglobulin M
15 Immunoglobulins
16 Immunoglobulins, Intravenous
17 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Comparison Between 12 vs. 20 Weeks of Co-trimoxazole as Maintenance Therapy for Melioidosis Completed NCT01420341 Phase 4 Co-trimoxazole 12;Co-trimoxazole 20
2 A Randomized Double Blinded Comparison of Ceftazidime and Meropenem in Severe Melioidosis Unknown status NCT00579956 Meropenem;Ceftazidime
3 Clinical Presentation of Melioidosis in Head and Neck Region Unknown status NCT03048513
4 A Cross-sectional Study Investigating the Causes of Pneumonia in Two Community Clinics in Two Yangon Townships, Myanmar Completed NCT03578133
5 Adapting a Rapid Lateral Flow Burkholderia Pseudomallei Immunoassay in Sarawak, Malaysia Completed NCT03528265
6 A Single-blind Stepped Wedge Cluster Randomized Controlled Behaviour Change Trial to Determine Effectiveness of Prevention Programme of Melioidosis in Diabetics in Ubon Ratchathani, Northeast Thailand Completed NCT02089152
7 Establishment of a Reference Clinical Sample Panel Allowing for the Development and Proof-of-concept Validation of an In-vitro Diagnostic Test for the Diagnosis of Melioidosis Completed NCT02668406
8 Evaluation of Rapid Diagnostic Tests (RDT) in Association With Clinical and Laboratory Predictors for the Diagnosis of Neglected Tropical Diseases (NTD) in Patients Presenting With Persistent Fever (≥1 Week) in Cambodia, Nepal, Democratic Republic of the Congo and Sudan Completed NCT01766830
9 Diagnostic Accuracy of the DPP Fever Panel II Asia and the DPP Micro Reader Recruiting NCT04299412

Search NIH Clinical Center for Melioidosis

Cochrane evidence based reviews: melioidosis

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Genetic Tests for Melioidosis

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Genetic tests related to Melioidosis:

# Genetic test Affiliating Genes
1 Melioidosis, Susceptibility to 29 TLR5
Sources

Anatomical Context for Melioidosis

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MalaCards organs/tissues related to Melioidosis:

40
Liver, Brain, Lung, Bone, Spleen, T Cells, Skin
Sources

Publications for Melioidosis

About this section

Articles related to Melioidosis:

(show top 50) (show all 2689)
# Title Authors PMID Year
1
Impaired TLR5 functionality is associated with survival in melioidosis. 61 57
23447684 2013
2
Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis). 54 61
17676990 2007
3
Induction of multiple chemokine and colony-stimulating factor genes in experimental Burkholderia pseudomallei infection. 61 54
11564157 2001
4
The CXC chemokines gamma interferon (IFN-gamma)-inducible protein 10 and monokine induced by IFN-gamma are released during severe melioidosis. 61 54
10858199 2000
5
Blood transcriptomics to characterize key biological pathways and identify biomarkers for predicting mortality in melioidosis. 61
33256556 2021
6
Antibiotic susceptibility of clinical Burkholderia pseudomallei isolates in northeast Thailand during 2015-2018 and the genomic characterization of β-lactam-resistant isolates. 61
33593842 2021
7
Evaluation of four sampling devices for Burkholderia pseudomallei laboratory aerosol studies. 61
33524051 2021
8
Genomic and RT-qPCR analysis of trimethoprim-sulfamethoxazole and meropenem resistance in Burkholderia pseudomallei clinical isolates. 61
33592059 2021
9
Whole-genome comparative analysis of Malaysian Burkholderia pseudomallei clinical isolates. 61
33565959 2021
10
Comparative virulence of three different strains of Burkholderia pseudomallei in an aerosol non-human primate model. 61
33571211 2021
11
Antimicrobial Susceptibility of Western Hemisphere Isolates of Burkholderia pseudomallei: Phenotypic and Genomic Analyses. 61
33570476 2021
12
Genomic Diversity of Burkholderia pseudomallei in Ceara, Brazil. 61
33536328 2021
13
In Vitro Antibacterial Activity and In Vivo Efficacy of Sulbactam-Durlobactam against Pathogenic Burkholderia Species. 61
33318017 2021
14
Identification of defective early immune responses to Burkholderia pseudomallei infection in a diet-induced murine model of type 2 diabetes. 61
33571673 2021
15
Identification and Characterization of Burkholderia pseudomallei from Localized Pyogenic Infections in Eastern India: A Clinico-Microbiological Study. 61
33534740 2021
16
Climate change and infectious diseases in Australia's Torres Strait Islands. 61
33522674 2021
17
Genomic Diversity of Burkholderia pseudomallei Isolates, Colombia. 61
33496648 2021
18
Diagnosis of melioidosis: the role of molecular techniques. 61
33595347 2021
19
Systematic review and meta-analysis of diagnostic tests for diagnosis of melioidosis. 61
33296681 2021
20
Isolated splenic abscess due to melioidosis in type 1 diabetes mellitus: laboratory diagnosis of Burkholderia pseudomallei in resource-restricted setting. 61
33541991 2021
21
Clinical characteristics and predictors of mortality in patients with melioidosis: the Kapit experience. 61
33590932 2021
22
Role of Burkholderia pseudomallei-Specific IgG2 in Adults with Acute Melioidosis, Thailand. 61
33496230 2021
23
Detection and differentiation of Burkholderia species with pathogenic potential in environmental soil samples. 61
33411797 2021
24
Whole-Genome Assemblies of 16 Burkholderia pseudomallei Isolates from Rivers in Laos. 61
33509986 2021
25
Inhibition of d-glycero-β-d-manno-heptose 1-phosphate adenylyltransferase from Burkholderia pseudomallei by epigallocatechin gallate and myricetin. 61
33346350 2021
26
Burkholderia pseudomallei OMVs derived from infection mimicking conditions elicit similar protection to a live-attenuated vaccine. 61
33514749 2021
27
Burkholderia pseudomallei Clinical Isolates Are Highly Susceptible In Vitro to Cefiderocol, a Siderophore Cephalosporin. 61
33168603 2021
28
Overview of the distribution of Burkholderia pseudomallei Sequence Types and the Emergence of Sequence Type 1342 in Malaysia. 61
33506647 2021
29
Melioidosis of the central nervous system; A potentially lethal impersonator. 61
33304815 2021
30
Case Report: Isolated Central Nervous System Melioidosis from a Non-Endemic Area. 61
33432911 2021
31
Cerebral melioidosis in an immunocompromised traveller: an argument for prevention. 61
33156336 2021
32
Acute kidney injury and its outcomes in melioidosis. 61
33515381 2021
33
Characteristic Honeycomb Sign in a Hepatic Abscess Secondary to Melioidosis. 61
33394028 2021
34
Current Advances in Burkholderia Vaccines Development. 61
33322641 2020
35
Burkholderia pseudomallei as an Enteric Pathogen: Identification of Virulence Factors Mediating Gastrointestinal Infection. 61
33106293 2020
36
A DUF4148 family protein produced inside RAW264.7 cells is a critical Burkholderia pseudomallei virulence factor. 61
32835600 2020
37
Multi locus sequence typing of clinical Burkholderia pseudomallei isolates from Malaysia. 61
33370273 2020
38
Intracranial Manifestation of Melioidosis: A Case Report and Long-Term Follow-Up. 61
33527048 2020
39
Investigation of Melioidosis Using Blood Culture and Indirect Hemagglutination Assay Serology among Patients with Fever, Northern Tanzania. 61
32996455 2020
40
Burkholderia pseudomallei sepsis with osteoarticular melioidosis of the hip in a patient with diabetes mellitus. 61
33370949 2020
41
A Persisting Nontropical Focus of Burkholderia pseudomallei with Limited Genome Evolution over Five Decades. 61
33172968 2020
42
Replicating bacterium-vectored vaccine expressing SARS-CoV-2 Membrane and Nucleocapsid proteins protects against severe COVID-19 disease in hamsters. 61
33236013 2020
43
Using Land Runoff to Survey the Distribution and Genetic Diversity of Burkholderia pseudomallei in Vientiane, Laos. 61
33257313 2020
44
A macrophage-targeted platform for extending drug dosing with polymer prodrugs for pulmonary infection prophylaxis. 61
33221351 2020
45
Mapping of the Denitrification Pathway in Burkholderia thailandensis by Genome-Wide Mutant Profiling. 61
32900830 2020
46
Cerebral abscess and calvarial osteomyelitis caused by Burkholderia pseudomallei in a renal transplant recipient. 61
33248011 2020
47
Functional redundancy of Burkholderia pseudomallei phospholipase C enzymes and their role in virulence. 61
33159122 2020
48
[Rare infections of the lungs not endemic in Germany]. 61
33162874 2020
49
Characterization of Burkholderia pseudomallei from spontaneous melioidosis in a Bornean orangutan. 61
33363342 2020
50
Safer In Vitro Drug Screening Models for Melioidosis Therapy Development. 61
32975176 2020
Sources

Variations for Melioidosis

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Expression for Melioidosis

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LifeMap Discovery
Genes differentially expressed in tissues of Melioidosis patients vs. healthy controls: 35 (show top 50) (show all 181)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 CD177 CD177 molecule Blood + 8.41 0.000
2 ZDHHC19 zinc finger DHHC-type palmitoyltransferase 19 Blood + 6.91 0.000
3 MMP8 matrix metallopeptidase 8 Blood + 6.49 0.000
4 SLC51A solute carrier family 51 subunit alpha Blood + 6.46 0.000
5 HP haptoglobin Blood + 6.23 0.000
6 FCER1A Fc fragment of IgE receptor Ia Blood - 6.00 0.000
7 GPR84 G protein-coupled receptor 84 Blood + 5.86 0.000
8 ANKRD22 ankyrin repeat domain 22 Blood + 5.72 0.000
9 OLAH oleoyl-ACP hydrolase Blood + 5.54 0.000
10 LRRN3 leucine rich repeat neuronal 3 Blood - 5.51 0.000
11 PCOLCE2 procollagen C-endopeptidase enhancer 2 Blood + 5.47 0.000
12 C1QC complement C1q C chain Blood + 5.42 0.000
13 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Blood + 5.39 0.000
14 CCNA1 cyclin A1 Blood + 5.14 0.000
15 C1QB complement C1q B chain Blood + 5.09 0.000
16 LINC00668 long intergenic non-protein coding RNA 668 Blood + 4.99 0.000
17 CACNA1E calcium voltage-gated channel subunit alpha1 E Blood + 4.98 0.000
18 FGF13 fibroblast growth factor 13 Blood + 4.96 0.000
19 CCN3 cellular communication network factor 3 Blood - 4.84 0.000
20 PLVAP plasmalemma vesicle associated protein Blood - 4.76 0.000
21 KL klotho Blood + 4.74 0.000
22 SLCO4A1 solute carrier organic anion transporter family member 4A1 Blood + 4.73 0.000
23 MYO10 myosin X Blood + 4.68 0.000
24 SLC1A3 solute carrier family 1 member 3 Blood + 4.68 0.000
25 RPGRIP1 RPGR interacting protein 1 Blood - 4.67 0.000
26 RETN resistin Blood + 4.65 0.000
27 CD274 CD274 molecule Blood + 4.44 0.000
28 MCEMP1 mast cell expressed membrane protein 1 Blood + 4.44 0.000
29 BMX BMX non-receptor tyrosine kinase Blood + 4.41 0.000
30 SERPINA1 serpin family A member 1 Blood + 4.38 0.000
31 CEACAM1 CEA cell adhesion molecule 1 Blood + 4.38 0.000
32 GRB10 growth factor receptor bound protein 10 Blood + 4.37 0.000
33 CACNA2D3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 Blood - 4.25 0.000
34 LINC01220 long intergenic non-protein coding RNA 1220 Blood + 4.20 0.000
35 LTF lactotransferrin Blood + 4.19 0.000
36 SLC26A8 solute carrier family 26 member 8 Blood + 4.18 0.000
37 ARG1 arginase 1 Blood + 4.17 0.000
38 IL18R1 interleukin 18 receptor 1 Blood + 4.17 0.000
39 IL1R2 interleukin 1 receptor type 2 Blood + 4.08 0.000
40 SLC2A11 solute carrier family 2 member 11 Blood + 4.06 0.000
41 CFH complement factor H Blood + 4.03 0.000
42 G0S2 G0/G1 switch 2 Blood + 4.02 0.000
43 MMP9 matrix metallopeptidase 9 Blood + 3.97 0.000
44 FCAR Fc fragment of IgA receptor Blood + 3.94 0.000
45 SCN9A sodium voltage-gated channel alpha subunit 9 Blood + 3.94 0.000
46 FAM20A FAM20A golgi associated secretory pathway pseudokinase Blood + 3.94 0.000
47 KRTAP19-6 keratin associated protein 19-6 Blood + 3.93 0.000
48 TDRD9 tudor domain containing 9 Blood + 3.92 0.000
49 KREMEN1 kringle containing transmembrane protein 1 Blood + 3.86 0.000
50 HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 Blood + 3.84 0.000
Search GEO for disease gene expression data for Melioidosis.
Sources

Pathways for Melioidosis

About this section

Pathways related to Melioidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.09 TREM1 TNF TLR5 TLR4 TLR2 TLR10
2
PEDF Induced Signaling 63
Show member pathways
 13.77 TNF TLR4 LY96 IL6 IL18 IL15
3
Activated TLR4 signalling 65
Show member pathways
 13.67 TLR5 TLR4 TLR2 TLR10 TLR1 NOD2
4
Akt Signaling 63
Show member pathways
 13.5 TNF TLR5 TLR4 TLR2 TLR10 TLR1
5
Cytokine Signaling in Immune system 65
Show member pathways
 13.47 TNF NOD2 IRAK3 IL6 IL18 IL15
6
PAK Pathway 63
Show member pathways
 13.35 TNF IL6 IL18 IL15 IL10 CXCL9
7
IL-2 Pathway 63
Show member pathways
 13.33 TREM1 TNF TLR5 TLR4 TLR2 TLR10
8
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.07 TREM1 TNF TLR5 TLR4 TLR2 TLR1
9
Allograft rejection 36 1
Show member pathways
 12.94 TNF IL6 IL15 IL10 IFNG CXCL9
10
Measles 36
Show member pathways
 12.91 TNF TLR4 TLR2 IL6 IL18 IFNG
11
Salmonella infection (KEGG) 36
Show member pathways
 12.89 TNF TLR5 TLR4 TLR2 LY96 IL6
12
NF-KappaB Family Pathway 63
Show member pathways
 12.85 TNF TLR5 TLR4 TLR2 TLR10 TLR1
13
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.78 TNF TLR5 TLR4 TLR2 TLR10 TLR1
14
Immune response IL-23 signaling pathway 23
Show member pathways
 12.74 TNF IL6 IL18 IL10 IFNG CXCL9
15
Th17 cell differentiation 36
Show member pathways
 12.74 TNF TLR5 TLR4 TLR2 NOD2 IL6
16
TRAF Pathway 63
Show member pathways
 12.73 TNF TLR5 TLR4 TLR2 TLR10 TLR1
17
T cell receptor signaling pathway 36
Show member pathways
 12.72 TNF TLR4 TLR2 IL6 IL10 IFNG
18
NF-kappaB Signaling 4
12.69 TNF TLR2 TLR1 IRAK3 IL10 IFNG
19
Antigen processing-Cross presentation 65
Show member pathways
 12.57 TLR4 TLR2 TLR1 LY96 CD14
20
VEGF Pathway (Qiagen) 63
Show member pathways
 12.57 TLR5 TLR4 TLR2 TLR10 TLR1 LY96
21
JAK-STAT signaling pathway 36
Show member pathways
 12.51 IL6 IL15 IL10 IFNG CSF3
22
Shigellosis 36
12.5 TNF TLR5 TLR4 IL18 CD14
23
IL-17 Family Signaling Pathways 64
Show member pathways
 12.49 TNF TLR5 TLR2 IL6 IFNG CSF3
24
Toll Comparative Pathway 63
Show member pathways
 12.48 TNF TLR4 LY96 IRAK3 IL6 IFNG
25
Development Slit-Robo signaling 23
Show member pathways
 12.45 TLR5 TLR4 LY96 CD14
26
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.44 TNF IL6 IL18 IL10 CXCL9
27
Toxoplasmosis 36
Show member pathways
 12.42 TNF TLR4 TLR2 LY96 IL10 IFNG
28
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.39 TNF IL6 IL18 IL15 IL10 IFNG
29
NOD-like receptor signaling pathway 36
12.36 TNF TLR4 NOD2 IL6 IL18
30
Colorectal Cancer Metastasis 63
12.3 TNF TLR5 TLR4 TLR2 TLR10 TLR1
31
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.3 TNF TLR5 TLR4 TLR2 TLR10 TLR1
32
Yersinia infection 36
12.22 TNF TLR4 IL6 IL18 IL10
33
MAPK Pathway 70
Show member pathways
 12.18 TLR5 TLR4 TLR2 TLR10 TLR1
34
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
12.17 TNF IL6 IL15 IL10 IFNG CSF3
35
Spinal Cord Injury 1
12.11 TNF TLR4 IL6 IFNG
36
Tuberculosis 36
12.11 TNF TLR4 TLR2 TLR1 NOD2 IL6
37
Interleukin-4 and 13 signaling 65
12.08 TNF IL6 IL18 IL10
38
Amoebiasis 36
12.08 TNF TLR4 TLR2 IL6 IL10 IFNG
39
TNF signaling pathway 36
12.07 TNF NOD2 IL6 IL15
40
NF-kappa B signaling pathway 36
12.04 TNF TLR4 LY96 CD14
41
Cytokine production by Th17 cells in CF (Mouse model) 23
Show member pathways
 12.04 TLR4 LY96 IL6 CSF3 CD14
42
Rheumatoid arthritis 36
12.02 TNF TLR4 TLR2 IL6 IL18 IL15
43
Hematopoietic cell lineage 36
12.01 TNF IL6 CSF3 CD14
44
Phagocytosis of Microbes 63
12 TLR5 TLR4 TLR2 TLR10 TLR1
45
Th17 Differentiation Pathway 64
Show member pathways
 12 TLR5 TLR4 TLR2 TLR10 TLR1 IL6
46
Innate Lymphoid Cell Differentiation Pathways 64
11.96 TNF IL18 IL15 IL10 IFNG
47
Pertussis 36
11.94 TNF TLR4 LY96 IL6 IL10 CD14
48
Dendritic Cells Developmental Lineage Pathway 64
11.92 TNF IL6 IL10 IFNG CD14
49
IgA-Producing B Cells in the Intestine 64
11.87 TNF TLR5 TLR4 TLR2 IL6 IL10
50
Transcription_NF-kB signaling pathway 23
11.76 TNF TLR4 LY96 IRAK3 CD14
Sources

GO Terms for Melioidosis

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Cellular components related to Melioidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 TREM1 TNF SERPINF2 LY96 IL6 IL18
2 cell surface GO:0009986 9.8 TNF TLR4 TLR2 SERPINF2 NOD2 IL15
3 membrane raft GO:0045121 9.71 TNF TLR2 TLR1 CD14
4 extracellular space GO:0005615 9.7 TNF SERPINF2 LY96 IL6 IL18 IL15
5 intrinsic component of plasma membrane GO:0031226 9.54 TLR4 TLR2 LY96
6 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.32 TLR2 TLR1
7 lipopolysaccharide receptor complex GO:0046696 8.8 TLR4 LY96 CD14

Biological processes related to Melioidosis according to GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.4 TLR5 TLR4 TLR2 TLR10 TLR1 IRAK3
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.32 TNF TLR4 TLR2 SERPINF2 NOD2 IL6
3 immune system process GO:0002376 10.27 TLR5 TLR4 TLR2 TLR10 TLR1 NOD2
4 innate immune response GO:0045087 10.22 TREM1 TLR5 TLR4 TLR2 TLR10 TLR1
5 positive regulation of gene expression GO:0010628 10.2 TNF TLR4 TLR2 IL6 IL18 IFNG
6 cytokine-mediated signaling pathway GO:0019221 10.14 TNF IRAK3 IL6 IL18 IL10 CSF3
7 defense response to bacterium GO:0042742 10.12 TNF TLR5 TLR4 NOD2 IL10
8 response to lipopolysaccharide GO:0032496 10.09 TLR4 TLR2 NOD2 LY96 IRAK3 IL10
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.07 TNF TLR4 TLR2 NOD2 IRAK3 IL6
10 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.06 TNF TLR4 SERPINF2 NOD2
11 defense response GO:0006952 10.05 TNF TLR1 NOD2 CXCL9
12 positive regulation of DNA-binding transcription factor activity GO:0051091 10.03 TNF IL6 IL10 CSF3
13 defense response to Gram-positive bacterium GO:0050830 10.02 TNF TLR2 NOD2 IL6
14 positive regulation of inflammatory response GO:0050729 10.02 TNF TLR4 TLR2 TLR10 IL18 IL15
15 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 10.01 NOD2 IL6 IL15 CSF3
16 positive regulation of JNK cascade GO:0046330 10.01 TNF TLR4 SERPINF2 NOD2
17 negative regulation of tumor necrosis factor production GO:0032720 10 TLR4 NOD2 IRAK3 IL10
18 negative regulation of interleukin-6 production GO:0032715 10 TNF TLR4 IRAK3 IL10
19 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10 TNF IL6 IL18 IL15 IFNG
20 positive regulation of interleukin-6 production GO:0032755 10 TNF TLR4 TLR2 TLR1 NOD2 IL6
21 apoptotic signaling pathway GO:0097190 9.99 TNF TLR4 LY96 CD14
22 positive regulation of interferon-gamma production GO:0032729 9.99 TNF TLR4 IL18 CD14
23 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.99 TNF TLR4 LY96 CD14
24 positive regulation of smooth muscle cell proliferation GO:0048661 9.99 TNF SERPINF2 IL6 IL18
25 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.99 TNF TLR4 TLR2 NOD2 IL18 CD14
26 humoral immune response GO:0006959 9.98 TREM1 TNF IL6 IFNG
27 positive regulation of interleukin-1 beta production GO:0032731 9.97 TNF TLR4 NOD2 IL6 IFNG
28 positive regulation of cytokine production GO:0001819 9.97 TNF TLR5 IL15 IL10 IFNG CD14
29 positive regulation of tumor necrosis factor production GO:0032760 9.97 TLR4 TLR2 TLR1 NOD2 LY96 IL6
30 positive regulation of phagocytosis GO:0050766 9.96 TNF NOD2 IL15 IFNG
31 positive regulation of chemokine production GO:0032722 9.96 TNF TLR4 TLR2 IL6 IFNG
32 positive regulation of nitric oxide biosynthetic process GO:0045429 9.95 TNF TLR5 TLR4 IFNG
33 toll-like receptor signaling pathway GO:0002224 9.95 TLR5 TLR4 TLR2 TLR10 TLR1 LY96
34 regulation of insulin secretion GO:0050796 9.94 TNF IL6 IFNG
35 cellular response to organic cyclic compound GO:0071407 9.94 TNF NOD2 IL18
36 response to glucocorticoid GO:0051384 9.94 TNF IL6 IL10
37 positive regulation of interleukin-12 production GO:0032735 9.94 TLR4 TLR2 NOD2 IFNG
38 positive regulation of interleukin-10 production GO:0032733 9.93 TLR4 TLR2 NOD2 IL6
39 microglial cell activation GO:0001774 9.93 TNF TLR2 TLR1 IFNG
40 negative regulation of interferon-gamma production GO:0032689 9.92 TLR4 NOD2 IL10
41 positive regulation of interleukin-8 production GO:0032757 9.92 TNF TLR5 TLR4 TLR2 TLR1 NOD2
42 positive regulation of JAK-STAT cascade GO:0046427 9.91 TNF IL6 IL10
43 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.91 TNF TLR4 NOD2 IL6
44 lipopolysaccharide-mediated signaling pathway GO:0031663 9.91 TNF TLR4 TLR2 LY96 IL18 CD14
45 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.9 TLR4 LY96 CD14
46 necroptotic process GO:0070266 9.89 TLR4 LY96 CD14
47 positive regulation of interleukin-17 production GO:0032740 9.89 NOD2 IL6 IL18 IL15
48 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.88 TLR4 LY96 CD14
49 toll-like receptor 4 signaling pathway GO:0034142 9.88 TLR4 LY96 CD14
50 negative regulation of interleukin-12 production GO:0032695 9.88 NOD2 IRAK3 IL10

Molecular functions related to Melioidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.43 TNF TLR5 TLR4 TLR2 TLR10 TLR1
2 signaling receptor activity GO:0038023 9.85 TREM1 TLR5 TLR4 TLR2 TLR10 TLR1
3 transmembrane signaling receptor activity GO:0004888 9.83 TLR5 TLR4 TLR2 TLR10 TLR1
4 lipopolysaccharide binding GO:0001530 9.62 TLR4 TLR2 LY96 CD14
5 lipopeptide binding GO:0071723 9.58 TLR2 TLR1 CD14
6 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.46 TLR4 TLR2 TLR10 TLR1
7 lipopolysaccharide receptor activity GO:0001875 9.43 TLR4 TLR2 LY96
8 NAD(P)+ nucleosidase activity GO:0050135 9.26 TLR4 TLR2 TLR10 TLR1
9 cytokine activity GO:0005125 9.23 TNF IL6 IL18 IL15 IL10 IFNG
Sources

Sources for Melioidosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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