MCID: MLP008
MIFTS: 19

Melphalan Allergy

Categories: Immune diseases

Aliases & Classifications for Melphalan Allergy

MalaCards integrated aliases for Melphalan Allergy:

Name: Melphalan Allergy 12 15
Alkeran Allergy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0040066
SNOMED-CT 67 293751001
UMLS 70 C0570673

Summaries for Melphalan Allergy

Disease Ontology : 12 A drug allergy that has allergic trigger melphalan.

MalaCards based summary : Melphalan Allergy, also known as alkeran allergy, is related to malignant anus melanoma and acneiform dermatitis. An important gene associated with Melphalan Allergy is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Phospholipase-C Pathway.

Related Diseases for Melphalan Allergy

Diseases related to Melphalan Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 malignant anus melanoma 10.0 NRAS IL2
2 acneiform dermatitis 10.0 NRAS BRAF
3 spitzoid melanoma 10.0 NRAS BRAF
4 benign struma ovarii 10.0 NRAS BRAF
5 erdheim-chester disease 10.0 NRAS BRAF
6 nodular malignant melanoma 10.0 NRAS BRAF
7 melanoma in congenital melanocytic nevus 10.0 NRAS BRAF
8 thyroid cancer, nonmedullary, 2 10.0 NRAS BRAF
9 hairy cell leukemia 10.0 IL2 BRAF
10 langerhans cell histiocytosis 10.0 NRAS BRAF
11 histiocytosis 10.0 NRAS BRAF
12 childhood acute myeloid leukemia 10.0 NRAS IL2
13 differentiated thyroid carcinoma 10.0 NRAS BRAF
14 serous cystadenocarcinoma 10.0 NRAS BRAF
15 cystadenocarcinoma 10.0 NRAS BRAF
16 ocular melanoma 9.9 NRAS IL2
17 uveal disease 9.9 NRAS IL2
18 cardiofaciocutaneous syndrome 1 9.9 NRAS BRAF
19 ovarian serous cystadenocarcinoma 9.9 NRAS BRAF
20 giant cell glioblastoma 9.9 NRAS BRAF
21 adrenal carcinoma 9.9 NRAS BRAF
22 adrenal cortical carcinoma 9.9 NRAS BRAF
23 bladder urothelial carcinoma 9.9 NRAS BRAF
24 thyroid gland follicular carcinoma 9.9 NRAS BRAF
25 thyroid gland anaplastic carcinoma 9.9 NRAS BRAF
26 hashimoto thyroiditis 9.9 NRAS BRAF
27 thymus gland disease 9.9 IL2 CD274
28 pilocytic astrocytoma 9.9 NRAS BRAF
29 thymus cancer 9.9 IL2 CD274
30 exanthem 9.9 IL2 CD274
31 central nervous system lymphoma 9.9 IL2 CD274
32 extrinsic cardiomyopathy 9.8 IL2 CD274
33 melanoma, cutaneous malignant 1 9.8 NRAS BRAF
34 vitiligo-associated multiple autoimmune disease susceptibility 1 9.8 IL2 CD274
35 adult t-cell leukemia 9.8 IL2 CD274
36 malignant spindle cell melanoma 9.8 NRAS CD274
37 craniopharyngioma 9.8 CD274 BRAF
38 lymphoproliferative syndrome 9.8 NRAS IL2
39 vulvar disease 9.8 NRAS CD274
40 peripartum cardiomyopathy 9.8 NRAS CD274
41 renal cell carcinoma, papillary, 1 9.8 NRAS BRAF
42 peripheral t-cell lymphoma 9.8 IL2 CD274
43 myocarditis 9.8 IL2 CD274
44 plasma cell neoplasm 9.8 NRAS BRAF
45 thymoma 9.7 IL2 CD274
46 bone marrow cancer 9.7 NRAS IL2
47 leukemia 9.7 NRAS IL2 BRAF
48 gliosarcoma 9.7 NRAS IL2 BRAF
49 rasopathy 9.7 NRAS IL2 BRAF
50 lymphoma, non-hodgkin, familial 9.7 NRAS IL2 BRAF

Graphical network of the top 20 diseases related to Melphalan Allergy:



Diseases related to Melphalan Allergy

Symptoms & Phenotypes for Melphalan Allergy

Drugs & Therapeutics for Melphalan Allergy

Search Clinical Trials , NIH Clinical Center for Melphalan Allergy

Genetic Tests for Melphalan Allergy

Anatomical Context for Melphalan Allergy

Publications for Melphalan Allergy

Articles related to Melphalan Allergy:

# Title Authors PMID Year
1
INTRAVITREOUS CHEMOTHERAPY FOR ACTIVE VITREOUS SEEDING FROM RETINOBLASTOMA: Outcomes After 192 Consecutive Injections. The 2015 Howard Naquin Lecture. 61
26630319 2016

Variations for Melphalan Allergy

Expression for Melphalan Allergy

Search GEO for disease gene expression data for Melphalan Allergy.

Pathways for Melphalan Allergy

Pathways related to Melphalan Allergy according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.8 NRAS IL2 BRAF
2
Show member pathways
12.64 NRAS IL2 BRAF
3 12.38 NRAS IL2 BRAF
4
Show member pathways
11.97 NRAS IL2 CD274
5
Show member pathways
11.91 NRAS IL2 BRAF
6
Show member pathways
11.8 NRAS BRAF
7
Show member pathways
11.75 NRAS BRAF
8
Show member pathways
11.74 NRAS BRAF
9
Show member pathways
11.69 IL2 BRAF
10 11.65 NRAS BRAF
11 11.64 NRAS BRAF
12 11.62 NRAS BRAF
13
Show member pathways
11.61 NRAS IL2 BRAF
14 11.6 NRAS BRAF
15
Show member pathways
11.6 NRAS BRAF
16 11.52 IL2 BRAF
17
Show member pathways
11.46 NRAS BRAF
18 11.39 NRAS BRAF
19
Show member pathways
11.32 NRAS BRAF
20
Show member pathways
11.28 IL2 BRAF
21 11.23 NRAS BRAF
22 11.04 NRAS BRAF
23 11.02 NRAS IL2 BRAF
24 10.95 NRAS BRAF
25 10.84 NRAS BRAF
26 10.66 NRAS IL2 BRAF

GO Terms for Melphalan Allergy

Biological processes related to Melphalan Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell proliferation GO:0042102 8.96 IL2 CD274
2 MAPK cascade GO:0000165 8.8 NRAS IL2 BRAF

Sources for Melphalan Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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