MCID: MLP008
MIFTS: 19

Melphalan Allergy

Categories: Immune diseases

Aliases & Classifications for Melphalan Allergy

MalaCards integrated aliases for Melphalan Allergy:

Name: Melphalan Allergy 12 15
Alkeran Allergy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0040066
UMLS 71 C0570673

Summaries for Melphalan Allergy

Disease Ontology : 12 A drug allergy that has allergic trigger melphalan.

MalaCards based summary : Melphalan Allergy, also known as alkeran allergy, is related to thyroid carcinoma and selection of therapeutic option in melanoma. An important gene associated with Melphalan Allergy is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Phospholipase-C Pathway.

Related Diseases for Melphalan Allergy

Diseases related to Melphalan Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 thyroid carcinoma 10.0 NRAS BRAF
2 selection of therapeutic option in melanoma 10.0 NRAS BRAF
3 selection of therapeutic option in colorectal cancer 10.0 NRAS BRAF
4 melanoma in congenital melanocytic nevus 10.0 NRAS BRAF
5 benign struma ovarii 10.0 NRAS BRAF
6 nodular malignant melanoma 9.9 NRAS BRAF
7 erdheim-chester disease 9.9 NRAS BRAF
8 acral lentiginous melanoma 9.9 NRAS BRAF
9 thyroiditis 9.9 IL2 BRAF
10 adrenocortical carcinoma, hereditary 9.9 NRAS BRAF
11 rasopathy 9.9 NRAS BRAF
12 thyroid tumor 9.9 NRAS BRAF
13 thyroid cancer, nonmedullary, 2 9.9 NRAS BRAF
14 langerhans cell histiocytosis 9.9 NRAS BRAF
15 histiocytosis 9.9 NRAS BRAF
16 cardiofaciocutaneous syndrome 1 9.9 NRAS BRAF
17 ocular melanoma 9.9 NRAS IL2
18 uveal disease 9.9 NRAS IL2
19 skin squamous cell carcinoma 9.9 NRAS BRAF
20 hairy cell leukemia 9.9 IL2 BRAF
21 serous cystadenocarcinoma 9.9 NRAS BRAF
22 cystadenocarcinoma 9.9 NRAS BRAF
23 skin melanoma 9.8 NRAS BRAF
24 rare cancer of corpus uteri 9.8 NRAS BRAF
25 recurrent respiratory papillomatosis 9.8 IL2 CD274
26 autoimmune disease of cardiovascular system 9.8 IL2 CD274
27 hashimoto thyroiditis 9.8 IL2 BRAF
28 thymus gland disease 9.8 IL2 CD274
29 thymus cancer 9.8 IL2 CD274
30 ovarian serous cystadenocarcinoma 9.8 NRAS BRAF
31 exanthem 9.8 IL2 CD274
32 central nervous system lymphoma 9.8 IL2 CD274
33 lymphoproliferative syndrome 9.8 NRAS IL2
34 malignant dermis tumor 9.7 NRAS CD274
35 malignant skin fibrous histiocytoma 9.7 NRAS CD274
36 peripartum cardiomyopathy 9.7 NRAS CD274
37 vitiligo-associated multiple autoimmune disease susceptibility 1 9.7 IL2 CD274
38 adult t-cell leukemia 9.7 IL2 CD274
39 renal cell carcinoma, papillary, 1 9.7 NRAS BRAF
40 peripheral t-cell lymphoma 9.6 IL2 CD274
41 melanoma, cutaneous malignant 1 9.6 NRAS BRAF
42 mucosal melanoma 9.6 NRAS IL2 BRAF
43 leukemia 9.6 NRAS IL2 BRAF
44 lymphoma, non-hodgkin, familial 9.5 NRAS IL2 BRAF
45 autoimmune lymphoproliferative syndrome 9.4 NRAS IL2
46 thymoma 9.4 IL2 CD274
47 differentiated thyroid carcinoma 9.4 NRAS CD274 BRAF
48 melanoma, uveal 9.3 NRAS CD274 BRAF
49 lynch syndrome 9.3 NRAS CD274 BRAF
50 bladder urothelial carcinoma 9.3 NRAS CD274 BRAF

Graphical network of the top 20 diseases related to Melphalan Allergy:



Diseases related to Melphalan Allergy

Symptoms & Phenotypes for Melphalan Allergy

Drugs & Therapeutics for Melphalan Allergy

Search Clinical Trials , NIH Clinical Center for Melphalan Allergy

Genetic Tests for Melphalan Allergy

Anatomical Context for Melphalan Allergy

Publications for Melphalan Allergy

Articles related to Melphalan Allergy:

# Title Authors PMID Year
1
INTRAVITREOUS CHEMOTHERAPY FOR ACTIVE VITREOUS SEEDING FROM RETINOBLASTOMA: Outcomes After 192 Consecutive Injections. The 2015 Howard Naquin Lecture. 61
26630319 2016

Variations for Melphalan Allergy

Expression for Melphalan Allergy

Search GEO for disease gene expression data for Melphalan Allergy.

Pathways for Melphalan Allergy

Pathways related to Melphalan Allergy according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 NRAS IL2 BRAF
2
Show member pathways
12.62 NRAS IL2 BRAF
3 12.38 NRAS IL2 BRAF
4
Show member pathways
11.88 NRAS IL2 BRAF
5
Show member pathways
11.87 NRAS BRAF
6
Show member pathways
11.87 NRAS IL2 CD274
7
Show member pathways
11.81 NRAS BRAF
8
Show member pathways
11.74 NRAS BRAF
9
Show member pathways
11.73 NRAS BRAF
10
Show member pathways
11.68 IL2 BRAF
11 11.64 NRAS BRAF
12 11.62 NRAS BRAF
13 11.6 NRAS BRAF
14 11.6 NRAS BRAF
15 11.56 NRAS IL2
16 11.5 IL2 BRAF
17
Show member pathways
11.44 NRAS BRAF
18 11.37 NRAS BRAF
19
Show member pathways
11.31 NRAS BRAF
20
Show member pathways
11.28 NRAS IL2 BRAF
21
Show member pathways
11.24 IL2 BRAF
22 11.21 NRAS BRAF
23 11 NRAS BRAF
24 10.9 NRAS BRAF
25 10.82 NRAS IL2 BRAF
26 10.78 NRAS BRAF

GO Terms for Melphalan Allergy

Biological processes related to Melphalan Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell proliferation GO:0042102 8.96 IL2 CD274
2 MAPK cascade GO:0000165 8.8 NRAS IL2 BRAF

Sources for Melphalan Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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