MPGN
MCID: MMB001
MIFTS: 51

Membranoproliferative Glomerulonephritis (MPGN)

Categories: Nephrological diseases, Rare diseases

Aliases & Classifications for Membranoproliferative Glomerulonephritis

MalaCards integrated aliases for Membranoproliferative Glomerulonephritis:

Name: Membranoproliferative Glomerulonephritis 12 53 37 15
Mesangiocapillary Glomerulonephritis 53 59 29
Primary Membranoproliferative Glomerulonephritis 53 59
Glomerulonephritis, Membranoproliferative 44 73
Mpgn 53 59
Glomerulonephritis Membranoproliferative 55
Chronic Glomerulonephritis, Lobular 12
Lobular Glomerulonephritis 12

Characteristics:

Orphanet epidemiological data:

59
primary membranoproliferative glomerulonephritis
Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 59  
Rare renal diseases


External Ids:

Disease Ontology 12 DOID:2920
MeSH 44 D015432
NCIt 50 C34644
SNOMED-CT 68 80321008
Orphanet 59 ORPHA54370
MESH via Orphanet 45 D015432
ICD10 via Orphanet 34 N00.5
UMLS via Orphanet 74 C0017662
KEGG 37 H01726
UMLS 73 C0017662

Summaries for Membranoproliferative Glomerulonephritis

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 54370Disease definitionMembranoproliferative glomerulonephritis (MPGN) is a chronic progressive kidney disorder characterized by glomerular capillary wall structural changes and mesangial cell proliferation leading to nephrotic syndrome, hypocomplementemia, hypertension, proteinuria and end-stage kidney disease. MPGN can be due to either idiopathic (type 1, 2 and 3 MPGN; see these terms) or secondary (associated with infectious and immune complex diseases) causes.Visit the Orphanet disease page for more resources.

MalaCards based summary : Membranoproliferative Glomerulonephritis, also known as mesangiocapillary glomerulonephritis, is related to dense deposit disease and complement factor h deficiency. An important gene associated with Membranoproliferative Glomerulonephritis is CFH (Complement Factor H), and among its related pathways/superpathways are Complement and coagulation cascades and Innate Immune System. The drugs rituximab and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and b cells, and related phenotypes are homeostasis/metabolism and normal

Wikipedia : 76 Membranoproliferative glomerulonephritis ("MPGN"), also known as mesangiocapillary glomerulonephritis,... more...

Related Diseases for Membranoproliferative Glomerulonephritis

Diseases related to Membranoproliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 224)
# Related Disease Score Top Affiliating Genes
1 dense deposit disease 33.3 C3 CFB CFH CFHR5
2 complement factor h deficiency 33.1 CD46 CFH
3 c3 glomerulopathy 32.6 C3 CFB CFHR5 CFP
4 cryoglobulinemia 30.9 CD79A TSLP
5 proliferative glomerulonephritis 30.4 C3 CD79A CFH
6 iga glomerulonephritis 30.3 ALB CD79A CFP NPHS1
7 focal segmental glomerulosclerosis 1 30.2 ICAM1 NPHS1
8 diffuse glomerulonephritis 30.2 ALB CFP
9 glomerulonephritis 30.2 ALB C3 C4A CD46 CD79A CFH
10 meningococcal meningitis 30.2 CFH CFP
11 microvascular complications of diabetes 3 30.2 ALB NPHS1
12 acute poststreptococcal glomerulonephritis 30.1 CD79A CFP
13 membranous nephropathy 30.1 ALB C3 CD79A NPHS1
14 hemolytic-uremic syndrome 30.0 C3 CD46 CFB CFH CFHR5
15 kidney disease 29.8 ALB C3 CFH NPHS1
16 hemolytic uremic syndrome, atypical 1 29.7 C3 CD46 CFB CFH CFHR5 CFP
17 complement deficiency 29.7 C3 C4A CD46 CFH CFP
18 thrombotic thrombocytopenic purpura 29.6 CD46 CFH
19 systemic lupus erythematosus 29.4 ALB C3 C4A CD79A CFB CFH
20 macular degeneration, age-related, 1 29.4 C3 CD46 CFB CFH CFHR5
21 membranoproliferative glomerulonephritis, x-linked 12.5
22 non-immunoglobulin-mediated membranoproliferative glomerulonephritis 12.5
23 nephrotic syndrome, type 7 12.1
24 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 11.5
25 lipodystrophy, partial, acquired 11.4
26 complement component 3 deficiency, autosomal recessive 11.4
27 mesangial proliferative glomerulonephritis 11.4
28 glomerulopathy with fibronectin deposits 2 11.3
29 lipodystrophy, partial, acquired, with low complement component c3, with or without glomerulonephritis 11.3
30 hypotrichosis-lymphedema-telangiectasia syndrome 11.3
31 hepatitis 10.9
32 hepatitis c 10.8
33 hepatitis c virus 10.8
34 viral infectious disease 10.6
35 lymphoma 10.5
36 hepatitis b 10.4
37 nephrotic syndrome 10.4
38 vasculitis 10.3
39 cryoglobulinemia, familial mixed 10.3
40 leukemia 10.3
41 leukemia, chronic lymphocytic 2 10.3
42 leukemia, chronic lymphocytic 10.3
43 lymphocytic leukemia 10.3
44 purpura 10.3
45 lupus erythematosus 10.3
46 leukemia, b-cell, chronic 10.3
47 complement component 3 deficiency 10.2 C3 CFP
48 diabetes mellitus 10.2
49 complement factor i deficiency 10.2 C3 CFP
50 multifocal choroiditis 10.2 CFB CFH

Graphical network of the top 20 diseases related to Membranoproliferative Glomerulonephritis:



Diseases related to Membranoproliferative Glomerulonephritis

Symptoms & Phenotypes for Membranoproliferative Glomerulonephritis

MGI Mouse Phenotypes related to Membranoproliferative Glomerulonephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.81 ALB C3 CD79A CFB CFH CFP
2 normal MP:0002873 9.5 ALB C3 CD79A CFB CFH CFP
3 renal/urinary system MP:0005367 9.1 ALB C3 CD79A CFB CFH NPHS1

Drugs & Therapeutics for Membranoproliferative Glomerulonephritis

Drugs for Membranoproliferative Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 3,Phase 1 174722-31-7 10201696
2
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
3 Antirheumatic Agents Phase 3,Phase 1
4 Immunologic Factors Phase 3,Phase 2,Phase 1,Not Applicable
5 Immunosuppressive Agents Phase 3
6 Cyclosporins Phase 3
7 Antifungal Agents Phase 3
8 Anti-Infective Agents Phase 3
9 Dermatologic Agents Phase 3
10 Calcineurin Inhibitors Phase 3
11
Daratumumab Approved Phase 2 945721-28-8
12 Complement System Proteins Phase 2
13 Antibodies Phase 2,Not Applicable
14 Immunoglobulins Phase 2,Not Applicable
15 Antigen-Antibody Complex Phase 2,Not Applicable
16 Antibodies, Monoclonal Phase 2
17
Aspirin Approved, Vet_approved Phase 1 50-78-2 2244
18 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1
19 Vaccines Phase 1
20 Angiotensin-Converting Enzyme Inhibitors Phase 1

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Effect of Rituximab in Treatment of Membranoproliferative Glomerulonephritis Not yet recruiting NCT03180723 Phase 3 Rituximab;Cyclosporin
2 Eculizumab in Primary MPGN Completed NCT02093533 Phase 2 Eculizumab
3 A Proof of Concept Study for a 12 Month Treatment in Patients With C3 Glomerulopathy (C3G) or Immune-Complex Membranoproliferative Glomerulonephritis (IC-MPGN) Recruiting NCT03459443 Phase 2 ACH-0144471
4 A Proof-of-Mechanism Study to Determine the Effect of ACH-0144471 on C3 Levels in Patients With C3G or IC-MPGN Recruiting NCT03124368 Phase 2 ACH-0144471
5 Daratumumab in Treatment of PGNMID and C3 GN Recruiting NCT03095118 Phase 2 Daratumumab
6 A Proof of Concept Study for 6 Month Treatment in Patients With C3 Glomerulopathy (C3G) Recruiting NCT03369236 Phase 2 ACH-0144471;Placebo
7 Synergetic B-cell Immunomodulation in SLE - 2nd Study. Recruiting NCT03747159 Phase 2 Belimumab Injection
8 Controlled Trial Evaluating Avacopan in C3 Glomerulopathy Recruiting NCT03301467 Phase 2 Avacopan;Avacopan Matching Placebo
9 Eculizumab Therapy for Dense Deposit Disease and C3 Nephropathy Unknown status NCT01221181 Phase 1 Eculizumab
10 Pilot Study of Rituximab for Membranoproliferative Glomerulonephritis Completed NCT00275613 Phase 1 Rituximab
11 Clinical Trial of CDX-1135 in Pediatric and Adult Patients With Dense Deposit Disease Terminated NCT01791686 Phase 1 CDX-1135
12 Sulodexide Treatment in Patients With Dense Deposit Disease Withdrawn NCT00583427 Phase 1 Sulodexide
13 Retrospective Analysis of Renal Prognosis in Patients With Chronic Kidney Disease Recruiting NCT03201406
14 Non-contrast Enhanced MRI in Patients With C3 Glomerulopathy (C3G) or Immune-complex Membranoproliferative Glomerulonephritis (IC-MPGN) Enrolled in the ACH471-205 Study Not yet recruiting NCT03723512 Not Applicable

Search NIH Clinical Center for Membranoproliferative Glomerulonephritis

Cochrane evidence based reviews: glomerulonephritis, membranoproliferative

Genetic Tests for Membranoproliferative Glomerulonephritis

Genetic tests related to Membranoproliferative Glomerulonephritis:

# Genetic test Affiliating Genes
1 Mesangiocapillary Glomerulonephritis 29

Anatomical Context for Membranoproliferative Glomerulonephritis

MalaCards organs/tissues related to Membranoproliferative Glomerulonephritis:

41
Kidney, Liver, B Cells, Lymph Node, Thyroid, T Cells, Myeloid

Publications for Membranoproliferative Glomerulonephritis

Articles related to Membranoproliferative Glomerulonephritis:

(show top 50) (show all 765)
# Title Authors Year
1
Treatment of recurrent, post-kidney transplant membranoproliferative glomerulonephritis with plasmapheresis and rituximab: A case report and literature review
. ( 30431428 )
2019
2
Membranoproliferative glomerulonephritis with unusual deposits of parallel arrangement striated structure: a new pathological entity?a8c. ( 29057733 )
2018
3
Modified scanning electron microscopy reveals pathological crosstalk between endothelial cells and podocytes in a murine model of membranoproliferative glomerulonephritis. ( 29980767 )
2018
4
Membranoproliferative glomerulonephritis-like findings for TAFRO syndrome, associated with an anterior mediastinal tumor: A case report. ( 29901607 )
2018
5
Membranoproliferative glomerulonephritis and interstitial nephritis in the setting of Epstein-Barr virus-related hemophagocytic syndromea8c. ( 29350173 )
2018
6
Autoimmune abnormalities of the alternative complement pathway in membranoproliferative glomerulonephritis and C3 glomerulopathy. ( 29948306 )
2018
7
Fundus changes in type III membranoproliferative glomerulonephritis: a case report. ( 29510686 )
2018
8
WaldenstrAPm macroglobulinemia presenting as cryoglobulinemic type II membranoproliferative glomerulonephritis. ( 29571917 )
2018
9
Long-term Eculizumab Therapy in a Child With Refractory Immune Complex-Mediated Membranoproliferative Glomerulonephritis. ( 29725653 )
2018
10
Membranoproliferative glomerulonephritis in a patient with chronic brucellosis. ( 30254855 )
2018
11
Membranoproliferative glomerulonephritis and C3 glomerulopathy in children: change in treatment modality? A report of a case series. ( 30094012 )
2018
12
Outcome of membranoproliferative glomerulonephritis and C3-glomerulopathy in children and adolescents. ( 30238151 )
2018
13
Short-term outcome of clinical and histopathologic variants of mesangiocapillary glomerulonephritis in children: A retrospective analysis from a tertiary care center. ( 30108386 )
2018
14
Rituximab treatment for immune-complex-mediated membranoproliferative glomerulonephritis. ( 30185139 )
2018
15
Mixed cryoglobulinemic membranoproliferative glomerulonephritis due to monoclonal gammopathy of undetermined significance: A case report. ( 30213019 )
2018
16
Successful Renal Outcome in Membranoproliferative Glomerulonephritis Following Treatment of the Underlying Subtle Clone: A Case Report. ( 30225464 )
2018
17
A case of Graves' disease associated with membranoproliferative glomerulonephritis and leukocytoclastic vasculitis. ( 30226207 )
2018
18
An autopsy case of TAFRO syndrome with membranoproliferative glomerulonephritis-like lesions. ( 30244358 )
2018
19
Development of membranoproliferative glomerulonephritis-like glomerulopathy in a patient with neutrophilia resulting from endogenous granulocyte-colony stimulating factor overproduction: a case report. ( 30286731 )
2018
20
Idiopathic membranoproliferative glomerulonephritis treated with mycophenolate mofetil. ( 30455941 )
2018
21
Clinical features and pathogenesis of membranoproliferative glomerulonephritis: a nationwide analysis of the Japan renal biopsy registry from 2007 to 2015. ( 29214407 )
2018
22
Rituximab therapy for hepatitis C virus-associated cryoglobulinemic membranoproliferative glomerulonephritis. ( 29445495 )
2018
23
Retinal manifestations in patients with complement-mediated membranoproliferative glomerulonephritis. ( 30078750 )
2018
24
Evaluation of cases of membranoproliferative glomerulonephritis according to newer classification: A retrospective record-based study. ( 30093770 )
2018
25
Management and outcome of multifetal gestation in a 35-year-old woman with childhood-onset membranoproliferative glomerulonephritis type I. ( 30101365 )
2018
26
Thrombotic microangiopathy mimicking membranoproliferative glomerulonephritis. ( 28168280 )
2017
27
Daclatasvir/asunaprevir based direct-acting antiviral therapy ameliorate hepatitis C virus-associated cryoglobulinemic membranoproliferative glomerulonephritis: a case report. ( 28356063 )
2017
28
A case of rapid amelioration of hepatitis C virus-associated cryoglobulinemic membranoproliferative glomerulonephritis treated by interferon-free directly acting antivirals for HCV in the absence of immunosuppressant. ( 28509128 )
2017
29
Membranoproliferative glomerulonephritis associated with Rosai-Dorfman disease. ( 29043148 )
2017
30
Clinical and histological features of patients with membranoproliferative glomerulonephritis classified by immunofluorescence findings. ( 29319772 )
2017
31
Membranoproliferative Glomerulonephritis Associated with a Human Immunodeficiency Virus Infection. ( 28761237 )
2017
32
Membranoproliferative Glomerulonephritis in Pregnancy. ( 28317619 )
2017
33
Hepatosplenic T-cell lymphoma associated with membranoproliferative glomerulonephritis. ( 28351190 )
2017
34
A 61-Year-Old Man With Membranoproliferative Glomerulonephritis. ( 29169517 )
2017
35
Retinal findings in membranoproliferative glomerulonephritis. ( 29260086 )
2017
36
Case Report of Spontaneous Remission of Biopsy-Proven Idiopathic Immune Complex-Mediated Membranoproliferative Glomerulonephritis. ( 28868298 )
2017
37
Rare genetic variant in the CFB gene presenting as atypical hemolytic uremic syndrome and immune complex diffuse membranoproliferative glomerulonephritis, with crescents, successfully treated with eculizumab. ( 28210841 )
2017
38
Atypical antiglomerular basement membranes disease with nephrotic-range proteinuria, mesangial proliferation, and membranoproliferative glomerulonephritis pattern of injury. ( 29265053 )
2017
39
Immune Complex Membranoproliferative Glomerulonephritis Associated with Transjugular Intrahepatic Portosystemic Shunts in Alcoholic Cirrhosis: Two Case Reports. ( 28226323 )
2017
40
Atypical haemolytic uremic syndrome (aHUS) and membranoproliferative glomerulonephritis (MPGN), different diseases or a spectrum of complement-mediated glomerular diseases? ( 28798244 )
2017
41
Unusual presentation of secondary syphilis: membranoproliferative glomerulonephritis andmuco-cutaneous lesions. ( 28950764 )
2017
42
Rituximab for Treatment of Membranoproliferative Glomerulonephritis and C3 Glomerulopathies. ( 28573137 )
2017
43
Association of membranoproliferative glomerulonephritis with renal cell carcinoma. ( 28004485 )
2017
44
SjAPgren Syndrome-Related Membranous Glomerulonephritis Progressing to Membranoproliferative Glomerulonephritis. ( 27904866 )
2016
45
Manifestations of Complement-Mediated and Immune Complex-Mediated Membranoproliferative Glomerulonephritis: A Comparative Consecutive Series. ( 26996341 )
2016
46
Membranoproliferative glomerulonephritis recurrence after kidney transplantation: using the new classification. ( 26754737 )
2016
47
Understanding the complement-mediated glomerular diseases: focus on membranoproliferative glomerulonephritis and C3 glomerulopathies. ( 27356907 )
2016
48
Anaerococcus urinomassiliensis sp. nov., isolated from a urine sample of a 17-year-old boy affected by autoimmune hepatitis and membranoproliferative glomerulonephritis. ( 27408746 )
2016
49
Reclassification of membranoproliferative glomerulonephritis: Identification of a new GN: C3GN. ( 27458560 )
2016
50
An unusual case of idiopathic crescentic membranoproliferative glomerulonephritis with posterior reversible encephalopathy syndrome. ( 27424710 )
2016

Variations for Membranoproliferative Glomerulonephritis

Expression for Membranoproliferative Glomerulonephritis

Search GEO for disease gene expression data for Membranoproliferative Glomerulonephritis.

Pathways for Membranoproliferative Glomerulonephritis

Pathways related to Membranoproliferative Glomerulonephritis according to KEGG:

37
# Name Kegg Source Accession
1 Complement and coagulation cascades hsa04610

GO Terms for Membranoproliferative Glomerulonephritis

Cellular components related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 ALB C3 C4A CFB CFH CFHR5
2 extracellular exosome GO:0070062 9.76 ALB C3 C4A CD46 CFB CFH
3 endoplasmic reticulum lumen GO:0005788 9.62 ALB C3 C4A CFP
4 extracellular space GO:0005615 9.56 ALB C3 C4A CFB CFH CFP
5 blood microparticle GO:0072562 9.02 ALB C3 C4A CFB CFH

Biological processes related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.77 C3 C4A CD46 CD79A CFB
2 innate immune response GO:0045087 9.73 C3 C4A CD46 CFB CFH CFP
3 cellular protein metabolic process GO:0044267 9.63 ALB C3 C4A
4 complement activation, classical pathway GO:0006958 9.58 C3 C4A CD46
5 complement activation GO:0006956 9.55 C3 C4A CFB CFH CFP
6 positive regulation of interleukin-10 production GO:0032733 9.43 CD46 TSLP
7 complement activation, alternative pathway GO:0006957 9.35 C3 CFB CFH CFHR5 CFP
8 positive regulation of apoptotic cell clearance GO:2000427 9.32 C3 C4A
9 regulation of complement activation GO:0030449 9.17 C3 C4A CD46 CFB CFH CFHR5

Molecular functions related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 8.96 C3 C4A
2 serine-type endopeptidase activity GO:0004252 8.92 C3 C4A CFB CFP

Sources for Membranoproliferative Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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