MCID: MMB001
MIFTS: 50

Membranoproliferative Glomerulonephritis

Categories: Rare diseases, Nephrological diseases

Aliases & Classifications for Membranoproliferative Glomerulonephritis

MalaCards integrated aliases for Membranoproliferative Glomerulonephritis:

Name: Membranoproliferative Glomerulonephritis 12 53 37 15
Mesangiocapillary Glomerulonephritis 53 59 29
Primary Membranoproliferative Glomerulonephritis 53 59
Glomerulonephritis, Membranoproliferative 44 73
Mpgn 53 59
Glomerulonephritis Membranoproliferative 55
Chronic Glomerulonephritis, Lobular 12
Lobular Glomerulonephritis 12

Characteristics:

Orphanet epidemiological data:

59
primary membranoproliferative glomerulonephritis
Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 59  
Rare renal diseases


External Ids:

Disease Ontology 12 DOID:2920
MeSH 44 D015432
NCIt 50 C34644
SNOMED-CT 68 80321008
Orphanet 59 ORPHA54370
MESH via Orphanet 45 D015432
ICD10 via Orphanet 34 N00.5
UMLS via Orphanet 74 C0017662
KEGG 37 H01726
UMLS 73 C0017662

Summaries for Membranoproliferative Glomerulonephritis

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 54370Disease definitionMembranoproliferative glomerulonephritis (MPGN) is a chronic progressive kidney disorder characterized by glomerular capillary wall structural changes and mesangial cell proliferation leading to nephrotic syndrome, hypocomplementemia, hypertension, proteinuria and end-stage kidney disease. MPGN can be due to either idiopathic (type 1, 2 and 3 MPGN; see these terms) or secondary (associated with infectious and immune complex diseases) causes.Visit the Orphanet disease page for more resources.

MalaCards based summary : Membranoproliferative Glomerulonephritis, also known as mesangiocapillary glomerulonephritis, is related to dense deposit disease and complement factor h deficiency. An important gene associated with Membranoproliferative Glomerulonephritis is CFH (Complement Factor H), and among its related pathways/superpathways are Complement and coagulation cascades and Innate Immune System. The drugs rituximab and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and b cells, and related phenotypes are homeostasis/metabolism and normal

Wikipedia : 76 Membranoproliferative glomerulonephritis (\"MPGN\"), also known as mesangiocapillary glomerulonephritis,... more...

Related Diseases for Membranoproliferative Glomerulonephritis

Diseases related to Membranoproliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 226)
# Related Disease Score Top Affiliating Genes
1 dense deposit disease 33.1 C3 CFB CFH CFHR5
2 complement factor h deficiency 33.1 CD46 CFH
3 c3 glomerulopathy 32.4 C3 CFB CFHR5 CFP
4 hemolytic uremic syndrome, atypical 1 31.3 CFH CFHR5
5 meningococcal meningitis 30.7 CFH CFP
6 cryoglobulinemia 30.7 CD79A TSLP
7 proliferative glomerulonephritis 30.6 C3 CD79A CFH
8 choroiditis 30.6 CFB CFH
9 acute poststreptococcal glomerulonephritis 30.6 CD79A CFP
10 rapidly progressive glomerulonephritis 30.0 CD79A ICAM1
11 membranous nephropathy 29.6 ALB C3 CD79A NPHS1
12 hemolytic-uremic syndrome 28.8 C3 CD46 CFB CFH CFHR5
13 iga glomerulonephritis 28.7 ALB C4A CD79A CFP NPHS1
14 systemic lupus erythematosus 28.3 ALB C3 C4A CD79A ICAM1
15 macular degeneration, age-related, 1 28.2 C3 CD46 CFB CFH CFHR5
16 glomerulonephritis 27.6 ALB C3 C4A CD79A CFH CFHR5
17 membranoproliferative glomerulonephritis, x-linked 12.4
18 non-immunoglobulin-mediated membranoproliferative glomerulonephritis 12.3
19 nephrotic syndrome, type 7 12.0
20 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 11.4
21 lipodystrophy, partial, acquired 11.3
22 complement component 3 deficiency, autosomal recessive 11.3
23 glomerulopathy with fibronectin deposits 2 11.1
24 lipodystrophy, partial, acquired, with low complement component c3, with or without glomerulonephritis 11.1
25 hypotrichosis-lymphedema-telangiectasia syndrome 11.1
26 complement factor i deficiency 10.7 C3 CFP
27 hepatitis 10.7
28 acute maxillary sinusitis 10.7 C3 CD79A
29 arteriolosclerosis 10.7 C3 CD79A
30 multifocal choroiditis 10.7 CFB CFH
31 hepatitis c 10.7
32 type i 10.6
33 hepatitis c virus 10.6
34 anemia, autoimmune hemolytic 10.6 C3 CD79A
35 kuhnt-junius degeneration 10.6 CFB CFH
36 autoimmune disease of blood 10.6 C3 CD79A
37 cork-handlers' disease 10.5 ALB CD79A
38 ostertagiasis 10.5 ALB CD79A
39 dermatitis, atopic, 3 10.5 ALB CD79A
40 gastrointestinal allergy 10.5 CD79A TSLP
41 root caries 10.5 ALB CD79A
42 parotitis 10.5 ALB CD79A
43 yellow nail syndrome 10.5 ALB CD79A
44 marasmus 10.5 ALB CD79A
45 chronic graft versus host disease 10.5 ALB CD79A
46 chronic maxillary sinusitis 10.5 C3 CD79A
47 occupational dermatitis 10.5 ALB C3
48 focal dermal hypoplasia 10.5 ALB CD79A
49 pediatric systemic lupus erythematosus 10.5 C3 C4A
50 ascending cholangitis 10.5 ALB C3

Graphical network of the top 20 diseases related to Membranoproliferative Glomerulonephritis:



Diseases related to Membranoproliferative Glomerulonephritis

Symptoms & Phenotypes for Membranoproliferative Glomerulonephritis

MGI Mouse Phenotypes related to Membranoproliferative Glomerulonephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.81 CFB CFH CFP ICAM1 NPHS1 TSLP
2 normal MP:0002873 9.5 CFH CFP NPHS1 ALB C3 CD79A
3 renal/urinary system MP:0005367 9.1 CFH NPHS1 ALB C3 CD79A CFB

Drugs & Therapeutics for Membranoproliferative Glomerulonephritis

Drugs for Membranoproliferative Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 3,Phase 1 174722-31-7 10201696
2
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
3 Antirheumatic Agents Phase 3,Phase 1
4 Antifungal Agents Phase 3
5 Anti-Infective Agents Phase 3
6 Calcineurin Inhibitors Phase 3
7 Cyclosporins Phase 3
8 Dermatologic Agents Phase 3
9 Immunosuppressive Agents Phase 3
10
Daratumumab Approved Phase 2 945721-28-8
11 Complement System Proteins Phase 2
12 Antigen-Antibody Complex Phase 2
13 Antibodies Phase 2
14 Antibodies, Monoclonal Phase 2
15 Immunoglobulins Phase 2
16
Aspirin Approved, Vet_approved Phase 1 50-78-2 2244
17 Angiotensin-Converting Enzyme Inhibitors Phase 1
18 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1
19 Vaccines Phase 1

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Effect of Rituximab in Treatment of Membranoproliferative Glomerulonephritis Not yet recruiting NCT03180723 Phase 3 Rituximab;Cyclosporin
2 Eculizumab in Primary MPGN Completed NCT02093533 Phase 2 Eculizumab
3 A Proof of Concept Study for a 12 Month Treatment in Patients With C3 Glomerulopathy (C3G) or Immune-Complex Membranoproliferative Glomerulonephritis (IC-MPGN) Recruiting NCT03459443 Phase 2 ACH-0144471
4 A Proof-of-Mechanism Study to Determine the Effect of ACH-0144471 on C3 Levels in Patients With C3G or IC-MPGN Recruiting NCT03124368 Phase 2 ACH-0144471
5 Daratumumab in Treatment of PGNMID and C3 GN Recruiting NCT03095118 Phase 2 Daratumumab
6 A Proof of Concept Study for 6 Month Treatment in Patients With C3 Glomerulopathy (C3G) Recruiting NCT03369236 Phase 2 ACH-0144471;Placebo
7 Controlled Trial Evaluating Avacopan in C3 Glomerulopathy Recruiting NCT03301467 Phase 2 Avacopan;Avacopan Matching Placebo
8 Eculizumab Therapy for Dense Deposit Disease and C3 Nephropathy Unknown status NCT01221181 Phase 1 Eculizumab
9 Pilot Study of Rituximab for Membranoproliferative Glomerulonephritis Completed NCT00275613 Phase 1 Rituximab
10 Clinical Trial of CDX-1135 in Pediatric and Adult Patients With Dense Deposit Disease Terminated NCT01791686 Phase 1 CDX-1135
11 Sulodexide Treatment in Patients With Dense Deposit Disease Withdrawn NCT00583427 Phase 1 Sulodexide
12 Retrospective Analysis of Renal Prognosis in Patients With Chronic Kidney Disease Recruiting NCT03201406

Search NIH Clinical Center for Membranoproliferative Glomerulonephritis

Cochrane evidence based reviews: glomerulonephritis, membranoproliferative

Genetic Tests for Membranoproliferative Glomerulonephritis

Genetic tests related to Membranoproliferative Glomerulonephritis:

# Genetic test Affiliating Genes
1 Mesangiocapillary Glomerulonephritis 29

Anatomical Context for Membranoproliferative Glomerulonephritis

MalaCards organs/tissues related to Membranoproliferative Glomerulonephritis:

41
Kidney, Liver, B Cells, Lymph Node, Thyroid, Myeloid, Endothelial

Publications for Membranoproliferative Glomerulonephritis

Articles related to Membranoproliferative Glomerulonephritis:

(show top 50) (show all 584)
# Title Authors Year
1
Membranoproliferative glomerulonephritis with unusual deposits of parallel arrangement striated structure: a new pathological entity?a8c. ( 29057733 )
2018
2
Modified scanning electron microscopy reveals pathological crosstalk between endothelial cells and podocytes in a murine model of membranoproliferative glomerulonephritis. ( 29980767 )
2018
3
Membranoproliferative glomerulonephritis-like findings for TAFRO syndrome, associated with an anterior mediastinal tumor: A case report. ( 29901607 )
2018
4
Membranoproliferative glomerulonephritis and interstitial nephritis in the setting of Epstein-Barr virus-related hemophagocytic syndromea8c. ( 29350173 )
2018
5
Autoimmune abnormalities of the alternative complement pathway in membranoproliferative glomerulonephritis and C3 glomerulopathy. ( 29948306 )
2018
6
Fundus changes in type III membranoproliferative glomerulonephritis: a case report. ( 29510686 )
2018
7
WaldenstrAPm macroglobulinemia presenting as cryoglobulinemic type II membranoproliferative glomerulonephritis. ( 29571917 )
2018
8
Long-term Eculizumab Therapy in a Child With Refractory Immune Complex-Mediated Membranoproliferative Glomerulonephritis. ( 29725653 )
2018
9
Rituximab therapy for hepatitis C virus-associated cryoglobulinemic membranoproliferative glomerulonephritis. ( 29445495 )
2018
10
Thrombotic microangiopathy mimicking membranoproliferative glomerulonephritis. ( 28168280 )
2017
11
Daclatasvir/asunaprevir based direct-acting antiviral therapy ameliorate hepatitis C virus-associated cryoglobulinemic membranoproliferative glomerulonephritis: a case report. ( 28356063 )
2017
12
A case of rapid amelioration of hepatitis C virus-associated cryoglobulinemic membranoproliferative glomerulonephritis treated by interferon-free directly acting antivirals for HCV in the absence of immunosuppressant. ( 28509128 )
2017
13
Membranoproliferative glomerulonephritis associated with Rosai-Dorfman disease. ( 29043148 )
2017
14
Clinical and histological features of patients with membranoproliferative glomerulonephritis classified by immunofluorescence findings. ( 29319772 )
2017
15
Membranoproliferative Glomerulonephritis Associated with a Human Immunodeficiency Virus Infection. ( 28761237 )
2017
16
Membranoproliferative Glomerulonephritis in Pregnancy. ( 28317619 )
2017
17
Hepatosplenic T-cell lymphoma associated with membranoproliferative glomerulonephritis. ( 28351190 )
2017
18
A 61-Year-Old Man With Membranoproliferative Glomerulonephritis. ( 29169517 )
2017
19
Retinal findings in membranoproliferative glomerulonephritis. ( 29260086 )
2017
20
Case Report of Spontaneous Remission of Biopsy-Proven Idiopathic Immune Complex-Mediated Membranoproliferative Glomerulonephritis. ( 28868298 )
2017
21
Rare genetic variant in the CFB gene presenting as atypical hemolytic uremic syndrome and immune complex diffuse membranoproliferative glomerulonephritis, with crescents, successfully treated with eculizumab. ( 28210841 )
2017
22
Atypical antiglomerular basement membranes disease with nephrotic-range proteinuria, mesangial proliferation, and membranoproliferative glomerulonephritis pattern of injury. ( 29265053 )
2017
23
Immune Complex Membranoproliferative Glomerulonephritis Associated with Transjugular Intrahepatic Portosystemic Shunts in Alcoholic Cirrhosis: Two Case Reports. ( 28226323 )
2017
24
Atypical haemolytic uremic syndrome (aHUS) and membranoproliferative glomerulonephritis (MPGN), different diseases or a spectrum of complement-mediated glomerular diseases? ( 28798244 )
2017
25
Unusual presentation of secondary syphilis: membranoproliferative glomerulonephritis andmuco-cutaneous lesions. ( 28950764 )
2017
26
Rituximab for Treatment of Membranoproliferative Glomerulonephritis and C3 Glomerulopathies. ( 28573137 )
2017
27
Clinical features and pathogenesis of membranoproliferative glomerulonephritis: a nationwide analysis of the Japan renal biopsy registry from 2007 to 2015. ( 29214407 )
2017
28
Association of membranoproliferative glomerulonephritis with renal cell carcinoma. ( 28004485 )
2017
29
SjAPgren Syndrome-Related Membranous Glomerulonephritis Progressing to Membranoproliferative Glomerulonephritis. ( 27904866 )
2016
30
Manifestations of Complement-Mediated and Immune Complex-Mediated Membranoproliferative Glomerulonephritis: A Comparative Consecutive Series. ( 26996341 )
2016
31
Membranoproliferative glomerulonephritis recurrence after kidney transplantation: using the new classification. ( 26754737 )
2016
32
Understanding the complement-mediated glomerular diseases: focus on membranoproliferative glomerulonephritis and C3 glomerulopathies. ( 27356907 )
2016
33
Anaerococcus urinomassiliensis sp. nov., isolated from a urine sample of a 17-year-old boy affected by autoimmune hepatitis and membranoproliferative glomerulonephritis. ( 27408746 )
2016
34
Reclassification of membranoproliferative glomerulonephritis: Identification of a new GN: C3GN. ( 27458560 )
2016
35
An unusual case of idiopathic crescentic membranoproliferative glomerulonephritis with posterior reversible encephalopathy syndrome. ( 27424710 )
2016
36
Successful Recovery of Acute Renal Transplant Failure in Recurrent Hepatitis C Virus-Associated Membranoproliferative Glomerulonephritis. ( 27778453 )
2016
37
Membranoproliferative glomerulonephritis and acute renal failure in a patient with chronic lymphocytic leukemia: Response to obinutuzumab. ( 27352257 )
2016
38
Membranoproliferative Glomerulonephritis Secondary to a Low-Grade Lymphoproliferative Disorder: A Rare Cause of Renal Dysfunction. ( 27812262 )
2016
39
Use of C4d as a diagnostic tool to classify membranoproliferative glomerulonephritis. ( 27595516 )
2016
40
Streptococcal Infection-related Nephritis (SIRN) Manifesting Membranoproliferative Glomerulonephritis Type I. ( 26984084 )
2016
41
Coexistence of atypical hemolytic uremic syndrome with membranoproliferative glomerulonephritis and antineutrophil cytoplasmic antibodies-associated vasculitis. ( 27424702 )
2016
42
Multimodal imaging of membranoproliferative glomerulonephritis type II. ( 28003788 )
2016
43
Differences in clinical findings, pathology, and outcomes between C3 glomerulonephritis and membranoproliferative glomerulonephritis. ( 26846787 )
2016
44
An association between membranoproliferative glomerulonephritis and metastatic colorectal carcinoma: a case report. ( 27439394 )
2016
45
Intravascular large B-cell lymphoma: masquerade as membranoproliferative glomerulonephritis. ( 27312458 )
2016
46
Intestinal Intravascular Large B-cell Lymphoma Mimicking Ulcerative Colitis with Secondary Membranoproliferative Glomerulonephritis. ( 27580553 )
2016
47
Morphological changes in membranoproliferative glomerulonephritis - a quantitative approach. ( 26743276 )
2015
48
Glomerular Diseases Dependent on Complement Activation, Including Atypical Hemolytic Uremic Syndrome, Membranoproliferative Glomerulonephritis, and C3 Glomerulopathy: Core Curriculum 2015. ( 26032627 )
2015
49
Membranoproliferative glomerulonephritis with masked monotypic immunoglobulin deposits. ( 26154922 )
2015
50
Successful treatment of hepatitis E virus-associated cryoglobulinemic membranoproliferative glomerulonephritis with ribavirin. ( 25708383 )
2015

Variations for Membranoproliferative Glomerulonephritis

Expression for Membranoproliferative Glomerulonephritis

Search GEO for disease gene expression data for Membranoproliferative Glomerulonephritis.

Pathways for Membranoproliferative Glomerulonephritis

Pathways related to Membranoproliferative Glomerulonephritis according to KEGG:

37
# Name Kegg Source Accession
1 Complement and coagulation cascades hsa04610

GO Terms for Membranoproliferative Glomerulonephritis

Cellular components related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.86 ALB C3 C4A CD46 CFB CFH
2 extracellular region GO:0005576 9.76 ALB C3 C4A CFB CFH CFHR5
3 endoplasmic reticulum lumen GO:0005788 9.62 ALB C3 C4A CFP
4 extracellular space GO:0005615 9.56 ALB C3 C4A CFB CFH CFP
5 blood microparticle GO:0072562 9.02 ALB C3 C4A CFB CFH

Biological processes related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.77 C3 C4A CD46 CD79A CFB
2 innate immune response GO:0045087 9.73 C3 C4A CD46 CFB CFH CFP
3 cellular protein metabolic process GO:0044267 9.63 ALB C3 C4A
4 complement activation, classical pathway GO:0006958 9.58 C3 C4A CD46
5 complement activation GO:0006956 9.55 C3 C4A CFB CFH CFP
6 positive regulation of interleukin-10 production GO:0032733 9.43 CD46 TSLP
7 complement activation, alternative pathway GO:0006957 9.35 C3 CFB CFH CFHR5 CFP
8 positive regulation of apoptotic cell clearance GO:2000427 9.32 C3 C4A
9 regulation of complement activation GO:0030449 9.17 C3 C4A CD46 CFB CFH CFHR5

Molecular functions related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 8.62 C3 C4A

Sources for Membranoproliferative Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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