MCID: MMB001
MIFTS: 51

Membranoproliferative Glomerulonephritis

Categories: Nephrological diseases, Rare diseases

Aliases & Classifications for Membranoproliferative Glomerulonephritis

MalaCards integrated aliases for Membranoproliferative Glomerulonephritis:

Name: Membranoproliferative Glomerulonephritis 12 54 38 15
Mesangiocapillary Glomerulonephritis 54 60 30
Primary Membranoproliferative Glomerulonephritis 54 60
Glomerulonephritis, Membranoproliferative 45 74
Mpgn 54 60
Glomerulonephritis Membranoproliferative 56
Chronic Glomerulonephritis, Lobular 12
Lobular Glomerulonephritis 12

Characteristics:

Orphanet epidemiological data:

60
primary membranoproliferative glomerulonephritis
Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 60  
Rare renal diseases


External Ids:

Disease Ontology 12 DOID:2920
KEGG 38 H01726
MeSH 45 D015432
NCIt 51 C34644
SNOMED-CT 69 80321008
MESH via Orphanet 46 D015432
ICD10 via Orphanet 35 N00.5
UMLS via Orphanet 75 C0017662
Orphanet 60 ORPHA54370
UMLS 74 C0017662

Summaries for Membranoproliferative Glomerulonephritis

NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 54370Disease definitionMembranoproliferative glomerulonephritis (MPGN) is a chronic progressive kidney disorder characterized by glomerular capillary wall structural changes and mesangial cell proliferation leading to nephrotic syndrome, hypocomplementemia, hypertension, proteinuria and end-stage kidney disease. MPGN can be due to either idiopathic (type 1, 2 and 3 MPGN; see these terms) or secondary (associated with infectious and immune complex diseases) causes.Visit the Orphanet disease page for more resources.

MalaCards based summary : Membranoproliferative Glomerulonephritis, also known as mesangiocapillary glomerulonephritis, is related to complement factor h deficiency and dense deposit disease. An important gene associated with Membranoproliferative Glomerulonephritis is CFH (Complement Factor H), and among its related pathways/superpathways are Complement and coagulation cascades and Innate Immune System. The drugs rituximab and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include kidney, b cells and liver, and related phenotypes are homeostasis/metabolism and normal

Wikipedia : 77 Membranoproliferative glomerulonephritis (MPGN) is a type of glomerulonephritis caused by deposits in... more...

Related Diseases for Membranoproliferative Glomerulonephritis

Diseases related to Membranoproliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 245)
# Related Disease Score Top Affiliating Genes
1 complement factor h deficiency 33.5 CD46 CFH
2 dense deposit disease 33.4 C3 CFB CFH CFHR5
3 c3 glomerulopathy 32.6 C3 CFB CFHR5 CFP
4 cryoglobulinemia 31.0 CD79A TSLP
5 proliferative glomerulonephritis 30.5 C3 CD79A CFH
6 meningococcal meningitis 30.4 CFH CFP
7 diffuse glomerulonephritis 30.4 ALB CFP
8 acute poststreptococcal glomerulonephritis 30.3 CD79A CFP
9 focal segmental glomerulosclerosis 1 30.3 ICAM1 NPHS1
10 microvascular complications of diabetes 3 30.2 ALB NPHS1
11 iga glomerulonephritis 30.2 ALB CD79A CFP NPHS1
12 membranous nephropathy 30.1 ALB C3 CD79A NPHS1
13 complement deficiency 30.1 C3 C4A CFH CFP
14 henoch-schoenlein purpura 29.8 C3 CD79A ICAM1
15 hemolytic-uremic syndrome 29.8 C3 CD46 CFB CFH CFHR5
16 kidney disease 29.7 ALB C3 CFH NPHS1
17 thrombotic thrombocytopenic purpura 29.5 CD46 CFH
18 hemolytic uremic syndrome, atypical 1 29.4 C3 CD46 CFB CFH CFHR5 CFP
19 systemic lupus erythematosus 29.3 ALB C3 C4A CD79A CFB ICAM1
20 glomerulonephritis 29.2 ALB C3 C4A CD46 CD79A CFH
21 macular degeneration, age-related, 1 29.2 C3 CD46 CFB CFH CFHR5
22 membranoproliferative glomerulonephritis, x-linked 12.6
23 non-immunoglobulin-mediated membranoproliferative glomerulonephritis 12.5
24 nephrotic syndrome, type 7 12.2
25 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 11.9
26 lipodystrophy, partial, acquired 11.5
27 complement component 3 deficiency, autosomal recessive 11.5
28 mesangial proliferative glomerulonephritis 11.4
29 glomerulopathy with fibronectin deposits 2 11.3
30 hypotrichosis-lymphedema-telangiectasia syndrome 11.3
31 lipodystrophy, partial, acquired, with low complement component c3, with or without glomerulonephritis 11.3
32 hepatitis 10.9
33 hepatitis c 10.9
34 hepatitis c virus 10.8
35 lymphoma 10.5
36 hepatitis b 10.5
37 nephrotic syndrome 10.4
38 leukemia 10.4
39 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 10.4
40 vasculitis 10.4
41 complement component 3 deficiency 10.3 C3 CFP
42 cryoglobulinemia, familial mixed 10.3
43 complement factor i deficiency 10.3 C3 CFP
44 multifocal choroiditis 10.3 CFB CFH
45 choroiditis 10.3 CFB CFH
46 arteriolosclerosis 10.3 C3 CD79A
47 leukemia, chronic lymphocytic 2 10.3
48 leukemia, chronic lymphocytic 10.3
49 lymphocytic leukemia 10.3
50 purpura 10.3

Graphical network of the top 20 diseases related to Membranoproliferative Glomerulonephritis:



Diseases related to Membranoproliferative Glomerulonephritis

Symptoms & Phenotypes for Membranoproliferative Glomerulonephritis

MGI Mouse Phenotypes related to Membranoproliferative Glomerulonephritis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.81 ALB C3 CD79A CFB CFH CFP
2 normal MP:0002873 9.5 ALB C3 CD79A CFB CFH CFP
3 renal/urinary system MP:0005367 9.1 ALB C3 CD79A CFB CFH NPHS1

Drugs & Therapeutics for Membranoproliferative Glomerulonephritis

Drugs for Membranoproliferative Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 3,Phase 2,Phase 1 174722-31-7 10201696
2
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
3 Immunologic Factors Phase 3,Phase 2,Phase 1,Not Applicable
4 Antirheumatic Agents Phase 3,Phase 2,Phase 1
5 Antineoplastic Agents, Immunological Phase 3,Phase 2,Phase 1
6 Immunosuppressive Agents Phase 3,Phase 2
7 Anti-Infective Agents Phase 3,Phase 2
8 Dermatologic Agents Phase 3
9 Cyclosporins Phase 3
10 Antifungal Agents Phase 3
11 Calcineurin Inhibitors Phase 3
12 Daratumumab Approved Phase 2 945721-28-8
13
Mycophenolic acid Approved Phase 2 24280-93-1 446541
14
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
15
belimumab Approved Phase 2 356547-88-1 5957 10451420
16
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
17
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
18
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
19
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
20 Complement System Proteins Phase 2
21 Antibodies Phase 2,Not Applicable
22 Antigen-Antibody Complex Phase 2,Not Applicable
23 Immunoglobulins Phase 2,Not Applicable
24 Antibodies, Monoclonal Phase 2
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
26 Hormones Phase 2
27 Peripheral Nervous System Agents Phase 2
28 Antitubercular Agents Phase 2
29 Antibiotics, Antitubercular Phase 2
30 Gastrointestinal Agents Phase 2
31 Antiemetics Phase 2
32 Anti-Inflammatory Agents Phase 2
33 Autonomic Agents Phase 2
34 glucocorticoids Phase 2
35 Anti-Bacterial Agents Phase 2
36 Methylprednisolone Acetate Phase 2
37 Protective Agents Phase 2
38 Neuroprotective Agents Phase 2
39 Prednisolone acetate Phase 2
40 Hormone Antagonists Phase 2
41
Aspirin Approved, Vet_approved Phase 1 50-78-2 2244
42 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1
43 Vaccines Phase 1
44 Angiotensin-Converting Enzyme Inhibitors Phase 1

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Effect of Rituximab in Treatment of Membranoproliferative Glomerulonephritis Not yet recruiting NCT03180723 Phase 3 Rituximab;Cyclosporin
2 Eculizumab in Primary MPGN Completed NCT02093533 Phase 2 Eculizumab
3 A Proof of Concept Study for a 12 Month Treatment in Patients With C3 Glomerulopathy (C3G) or Immune-Complex Membranoproliferative Glomerulonephritis (IC-MPGN) Recruiting NCT03459443 Phase 2 ACH-0144471
4 A Proof-of-Mechanism Study to Determine the Effect of ACH-0144471 on C3 Levels in Patients With C3G or IC-MPGN Recruiting NCT03124368 Phase 2 ACH-0144471
5 Daratumumab in Treatment of PGNMID and C3 GN Recruiting NCT03095118 Phase 2 Daratumumab
6 A Proof of Concept Study for 6 Month Treatment in Patients With C3 Glomerulopathy (C3G) Recruiting NCT03369236 Phase 2 ACH-0144471;Placebo
7 Synergetic B-cell Immunomodulation in SLE - 2nd Study. Recruiting NCT03747159 Phase 2 Belimumab Injection
8 Controlled Trial Evaluating Avacopan in C3 Glomerulopathy Recruiting NCT03301467 Phase 2 Avacopan;Avacopan Matching Placebo
9 Pilot Study of Rituximab for Membranoproliferative Glomerulonephritis Completed NCT00275613 Phase 1 Rituximab
10 Eculizumab Therapy for Dense Deposit Disease and C3 Nephropathy Completed NCT01221181 Phase 1 Eculizumab
11 Clinical Trial of CDX-1135 in Pediatric and Adult Patients With Dense Deposit Disease Terminated NCT01791686 Phase 1 CDX-1135
12 Sulodexide Treatment in Patients With Dense Deposit Disease Withdrawn NCT00583427 Phase 1 Sulodexide
13 Retrospective Analysis of Renal Prognosis in Patients With Chronic Kidney Disease Recruiting NCT03201406
14 Non-contrast Enhanced MRI in Patients With C3 Glomerulopathy (C3G) or Immune-complex Membranoproliferative Glomerulonephritis (IC-MPGN) Enrolled in the ACH471-205 Study Not yet recruiting NCT03723512 Not Applicable

Search NIH Clinical Center for Membranoproliferative Glomerulonephritis

Cochrane evidence based reviews: glomerulonephritis, membranoproliferative

Genetic Tests for Membranoproliferative Glomerulonephritis

Genetic tests related to Membranoproliferative Glomerulonephritis:

# Genetic test Affiliating Genes
1 Mesangiocapillary Glomerulonephritis 30

Anatomical Context for Membranoproliferative Glomerulonephritis

MalaCards organs/tissues related to Membranoproliferative Glomerulonephritis:

42
Kidney, B Cells, Liver, Thyroid, T Cells, Lymph Node, Endothelial

Publications for Membranoproliferative Glomerulonephritis

Articles related to Membranoproliferative Glomerulonephritis:

(show top 50) (show all 788)
# Title Authors Year
1
Effectiveness of cryofiltration and mizoribine combination with oral steroid therapy in a patient with membranoproliferative glomerulonephritis due to essential cryoglobulinemia. ( 30927247 )
2019
2
Treatment of recurrent, post-kidney transplant membranoproliferative glomerulonephritis with plasmapheresis and rituximab: A case report and literature review
. ( 30431428 )
2019
3
Successful entecavir plus prednisolone treatment for hepatitis B virus-associated membranoproliferative glomerulonephritis: A case report. ( 30633192 )
2019
4
Characteristics of membranoproliferative glomerulonephritis based on a new classification at a single center. ( 30854618 )
2019
5
Kimura's disease with membranoproliferative glomerulonephritis: a case report with literature review. ( 30912457 )
2019
6
C5 Convertase Blockade in Membranoproliferative Glomerulonephritis: A Single-Arm Clinical Trial. ( 30929851 )
2019
7
Regression of hepatitis C virus-associated membranoproliferative glomerulonephritis with direct-acting antiviral therapy after liver transplantation. ( 31033081 )
2019
8
Retinal manifestations in patients with complement-mediated membranoproliferative glomerulonephritis. ( 30078750 )
2019
9
Management and outcome of multifetal gestation in a 35-year-old woman with childhood-onset membranoproliferative glomerulonephritis type I. ( 30101365 )
2019
10
An autopsy case of TAFRO syndrome with membranoproliferative glomerulonephritis-like lesions. ( 30244358 )
2019
11
Membranoproliferative glomerulonephritis in a patient with chronic brucellosis. ( 30254855 )
2018
12
Autoimmune abnormalities of the alternative complement pathway in membranoproliferative glomerulonephritis and C3 glomerulopathy. ( 29948306 )
2018
13
Membranoproliferative glomerulonephritis and C3 glomerulopathy in children: change in treatment modality? A report of a case series. ( 30094012 )
2018
14
Outcome of membranoproliferative glomerulonephritis and C3-glomerulopathy in children and adolescents. ( 30238151 )
2018
15
Sofosbuvir and Daclatsvir in Treatment of Hepatitis C Virus-related Membranoproliferative Glomerulonephritis With Cryoglobulinemia in a Patient With Hepatitis C Genotype 4. ( 30595569 )
2018
16
Idiopathic membranoproliferative glomerulonephritis treated with mycophenolate mofetil. ( 30455941 )
2018
17
Overexpression of toll-like receptor 9 correlates with podocyte injury in a murine model of autoimmune membranoproliferative glomerulonephritis. ( 30592438 )
2018
18
Hepatitis C Virus-associated Membranoproliferative Glomerulonephritis Treated with Directly Acting Antiviral Therapy. ( 30647501 )
2018
19
Membranoproliferative glomerulonephritis in Russian population. ( 30701832 )
2018
20
Long-term Eculizumab Therapy in a Child With Refractory Immune Complex-Mediated Membranoproliferative Glomerulonephritis. ( 29725653 )
2018
21
Membranoproliferative glomerulonephritis-like findings for TAFRO syndrome, associated with an anterior mediastinal tumor: A case report. ( 29901607 )
2018
22
Modified scanning electron microscopy reveals pathological crosstalk between endothelial cells and podocytes in a murine model of membranoproliferative glomerulonephritis. ( 29980767 )
2018
23
Evaluation of cases of membranoproliferative glomerulonephritis according to newer classification: A retrospective record-based study. ( 30093770 )
2018
24
Short-term outcome of clinical and histopathologic variants of mesangiocapillary glomerulonephritis in children: A retrospective analysis from a tertiary care center. ( 30108386 )
2018
25
Rituximab treatment for immune-complex-mediated membranoproliferative glomerulonephritis. ( 30185139 )
2018
26
Mixed cryoglobulinemic membranoproliferative glomerulonephritis due to monoclonal gammopathy of undetermined significance: A case report. ( 30213019 )
2018
27
Successful Renal Outcome in Membranoproliferative Glomerulonephritis Following Treatment of the Underlying Subtle Clone: A Case Report. ( 30225464 )
2018
28
A case of Graves' disease associated with membranoproliferative glomerulonephritis and leukocytoclastic vasculitis. ( 30226207 )
2018
29
Development of membranoproliferative glomerulonephritis-like glomerulopathy in a patient with neutrophilia resulting from endogenous granulocyte-colony stimulating factor overproduction: a case report. ( 30286731 )
2018
30
Unusual presentation of secondary syphilis: membranoproliferative glomerulonephritis andmuco-cutaneous lesions. ( 28950764 )
2018
31
Membranoproliferative glomerulonephritis with unusual deposits of parallel arrangement striated structure: a new pathological entity?
. ( 29057733 )
2018
32
Clinical features and pathogenesis of membranoproliferative glomerulonephritis: a nationwide analysis of the Japan renal biopsy registry from 2007 to 2015. ( 29214407 )
2018
33
Membranoproliferative glomerulonephritis and interstitial nephritis in the setting of Epstein-Barr virus-related hemophagocytic syndrome
. ( 29350173 )
2018
34
Rituximab therapy for hepatitis C virus-associated cryoglobulinemic membranoproliferative glomerulonephritis. ( 29445495 )
2018
35
Fundus changes in type III membranoproliferative glomerulonephritis: a case report. ( 29510686 )
2018
36
Waldenström macroglobulinemia presenting as cryoglobulinemic type II membranoproliferative glomerulonephritis. ( 29571917 )
2018
37
Case Report of Spontaneous Remission of Biopsy-Proven Idiopathic Immune Complex-Mediated Membranoproliferative Glomerulonephritis. ( 28868298 )
2017
38
Membranoproliferative glomerulonephritis associated with Rosai-Dorfman disease. ( 29043148 )
2017
39
A 61-Year-Old Man With Membranoproliferative Glomerulonephritis. ( 29169517 )
2017
40
Retinal findings in membranoproliferative glomerulonephritis. ( 29260086 )
2017
41
Atypical antiglomerular basement membranes disease with nephrotic-range proteinuria, mesangial proliferation, and membranoproliferative glomerulonephritis pattern of injury. ( 29265053 )
2017
42
Clinical and histological features of patients with membranoproliferative glomerulonephritis classified by immunofluorescence findings. ( 29319772 )
2017
43
Association of membranoproliferative glomerulonephritis with renal cell carcinoma. ( 28004485 )
2017
44
Thrombotic microangiopathy mimicking membranoproliferative glomerulonephritis. ( 28168280 )
2017
45
Rare genetic variant in the CFB gene presenting as atypical hemolytic uremic syndrome and immune complex diffuse membranoproliferative glomerulonephritis, with crescents, successfully treated with eculizumab. ( 28210841 )
2017
46
Immune Complex Membranoproliferative Glomerulonephritis Associated with Transjugular Intrahepatic Portosystemic Shunts in Alcoholic Cirrhosis: Two Case Reports. ( 28226323 )
2017
47
Membranoproliferative Glomerulonephritis in Pregnancy. ( 28317619 )
2017
48
Hepatosplenic T-cell lymphoma associated with membranoproliferative glomerulonephritis. ( 28351190 )
2017
49
Daclatasvir/asunaprevir based direct-acting antiviral therapy ameliorate hepatitis C virus-associated cryoglobulinemic membranoproliferative glomerulonephritis: a case report. ( 28356063 )
2017
50
A case of rapid amelioration of hepatitis C virus-associated cryoglobulinemic membranoproliferative glomerulonephritis treated by interferon-free directly acting antivirals for HCV in the absence of immunosuppressant. ( 28509128 )
2017

Variations for Membranoproliferative Glomerulonephritis

Expression for Membranoproliferative Glomerulonephritis

Search GEO for disease gene expression data for Membranoproliferative Glomerulonephritis.

Pathways for Membranoproliferative Glomerulonephritis

Pathways related to Membranoproliferative Glomerulonephritis according to KEGG:

38
# Name Kegg Source Accession
1 Complement and coagulation cascades hsa04610

GO Terms for Membranoproliferative Glomerulonephritis

Cellular components related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 ALB C3 C4A CFB CFH CFHR5
2 extracellular exosome GO:0070062 9.76 ALB C3 C4A CD46 CFB CFH
3 endoplasmic reticulum lumen GO:0005788 9.62 ALB C3 C4A CFP
4 extracellular space GO:0005615 9.56 ALB C3 C4A CFB CFH CFP
5 blood microparticle GO:0072562 9.02 ALB C3 C4A CFB CFH

Biological processes related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.77 C3 C4A CD46 CD79A CFB
2 innate immune response GO:0045087 9.73 C3 C4A CD46 CFB CFH CFP
3 cellular protein metabolic process GO:0044267 9.63 ALB C3 C4A
4 complement activation, classical pathway GO:0006958 9.58 C3 C4A CD46
5 complement activation GO:0006956 9.55 C3 C4A CFB CFH CFP
6 positive regulation of interleukin-10 production GO:0032733 9.43 CD46 TSLP
7 complement activation, alternative pathway GO:0006957 9.35 C3 CFB CFH CFHR5 CFP
8 positive regulation of apoptotic cell clearance GO:2000427 9.32 C3 C4A
9 regulation of complement activation GO:0030449 9.17 C3 C4A CD46 CFB CFH CFHR5

Molecular functions related to Membranoproliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 8.96 C3 C4A
2 serine-type endopeptidase activity GO:0004252 8.32 CFB

Sources for Membranoproliferative Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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