MCID: MNN001
MIFTS: 37

Meningeal Melanocytoma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Meningeal Melanocytoma

MalaCards integrated aliases for Meningeal Melanocytoma:

Name: Meningeal Melanocytoma 12 58 15 17 71
Leptomeningeal Melanocytoma 12
Melanocytoma of Meninges 12

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:5900
NCIt 49 C4662
UMLS via Orphanet 72 C1266113
Orphanet 58 ORPHA252046
UMLS 71 C1266113

Summaries for Meningeal Melanocytoma

MalaCards based summary : Meningeal Melanocytoma, also known as leptomeningeal melanocytoma, is related to meningioma, radiation-induced and meningeal melanoma, and has symptoms including vomiting, headache and neurologic symptoms. An important gene associated with Meningeal Melanocytoma is GNAQ (G Protein Subunit Alpha Q), and among its related pathways/superpathways are Neuroscience and Ca, cAMP and Lipid Signaling. The drugs Donepezil and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and liver.

Related Diseases for Meningeal Melanocytoma

Diseases related to Meningeal Melanocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 meningioma, radiation-induced 31.3 S100B MUC1
2 meningeal melanoma 30.4 MLANA GNAQ GNA11
3 melanotic neurilemmoma 30.4 MLANA GNAQ
4 neurilemmoma 30.3 S100B MUC1 ENO2
5 melanomatosis 30.1 MLANA GNAQ GNA11
6 neurofibroma 30.1 S100B MUC1 MLANA
7 mongolian spot 30.0 MLANA GNAQ GNA11
8 meningeal melanomatosis 29.9 MLANA GNAQ GNA11
9 skin melanoma 29.9 MLANA GNAQ GNA11
10 neuroma 29.6 S100B MUC1 ENO2
11 hemangioma 29.5 MUC1 GNAQ ENO2
12 melanoma, uveal 29.2 S100B MLANA GNAQ GNA11 EIF1AX
13 meningioma, familial 10.6
14 spinal meningioma 10.6
15 secretory meningioma 10.6
16 lymphoplasmacyte-rich meningioma 10.6
17 nevus of ota 10.5
18 sclerosing perineurioma 10.4 S100B MUC1
19 perineurioma 10.4 S100B MUC1
20 localized hypertrophic neuropathy 10.4 S100B MUC1
21 reticular perineurioma 10.4 S100B MUC1
22 non-functioning pituitary adenoma 10.4 S100B MUC1
23 aggressive digital papillary adenocarcinoma 10.4 S100B MUC1
24 cerebral primitive neuroectodermal tumor 10.4 S100B MUC1
25 rare tumor 10.4
26 cutaneous leiomyosarcoma 10.4 S100B MUC1
27 syringocystadenoma papilliferum 10.4 S100B MUC1
28 intraneural perineurioma 10.4 S100B MUC1
29 eccrine porocarcinoma 10.4 S100B MUC1
30 anaplastic ependymoma 10.4 S100B MUC1
31 chordoid meningioma 10.3 S100B MUC1
32 polymorphous low-grade adenocarcinoma 10.3 S100B MUC1
33 spindle cell rhabdomyosarcoma 10.3 S100B MUC1
34 fibrous meningioma 10.3 S100B MUC1
35 ovarian small cell carcinoma 10.3 S100B MUC1
36 dendritic cell tumor 10.3 S100B MUC1
37 spiradenoma 10.3 S100B MUC1
38 clear cell meningioma 10.3 S100B MUC1
39 melanoma in congenital melanocytic nevus 10.3 S100B MLANA
40 monophasic synovial sarcoma 10.3 S100B MUC1
41 lentigo maligna melanoma 10.3 S100B MLANA
42 chordoid glioma 10.3 S100B MUC1
43 microglandular adenosis 10.3 S100B MUC1
44 malignant anus melanoma 10.3 MLANA GNAQ
45 syringoma 10.3 S100B MUC1
46 siderosis 10.3
47 tièche-jadassohn nevus 10.3
48 superficial siderosis 10.3
49 myxopapillary ependymoma 10.3 S100B MUC1
50 epithelioid cell melanoma 10.3 MLANA GNAQ

Graphical network of the top 20 diseases related to Meningeal Melanocytoma:



Diseases related to Meningeal Melanocytoma

Symptoms & Phenotypes for Meningeal Melanocytoma

UMLS symptoms related to Meningeal Melanocytoma:


vomiting, headache, neurologic symptoms

Drugs & Therapeutics for Meningeal Melanocytoma

Drugs for Meningeal Melanocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Donepezil Approved Phase 3 120014-06-4 3152
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
3 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
4 Neurotransmitter Agents Phase 3
5 Nootropic Agents Phase 3
6 Cholinergic Agents Phase 3
7 Cholinesterase Inhibitors Phase 3
8 Narcotics Phase 3
9 Liver Extracts Phase 3
10 Anesthetics Phase 3
11 Anesthetics, General Phase 3
12 Analgesics, Opioid Phase 3
13 Adjuvants, Anesthesia Phase 3
14 Central Nervous System Depressants Phase 3
15 Anesthetics, Intravenous Phase 3
16 Cola Phase 3
17 Analgesics Phase 3
18
Verteporfin Approved, Investigational Phase 1 129497-78-5
19
Trioxsalen Approved Phase 1 3902-71-4 5585
20
Sirolimus Approved, Investigational Phase 1 53123-88-9 5284616 6436030 46835353
21
Everolimus Approved Phase 1 159351-69-6 6442177 70789204
22
Miconazole Approved, Investigational, Vet_approved Phase 1 22916-47-8 4189
23 Dermatologic Agents Phase 1
24 Photosensitizing Agents Phase 1
25 Dihematoporphyrin Ether Phase 1
26 Immunologic Factors Phase 1
27 Dialysis Solutions Phase 1
28 Anti-Infective Agents Phase 1
29 Mitogens Phase 1
30 Antibiotics, Antitubercular Phase 1
31 Anti-Bacterial Agents Phase 1
32 Antifungal Agents Phase 1
33 Immunosuppressive Agents Phase 1
34
Temozolomide Approved, Investigational 85622-93-1 5394
35 Alkylating Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Double Blind, Placebo Controlled Study of Donepezil in the Irradiated Brain Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
2 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Photodynamic Therapy For Childhood Brain Tumors, A Phase I Study Unknown status NCT00002647 Phase 1 verteporfin
4 A Pilot Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors Completed NCT00784914 Phase 1 temsirolimus
5 Identification of Genes Involved in the Pathogenesis of Gliomas by Transcriptome Analysis Completed NCT00967200
6 Temozolomide Induced Changes in Semen/Sperm Analysis in Men With Newly Diagnosed, Progressive or Recurrent Primary Malignant Brain Tumors Completed NCT00499798

Search NIH Clinical Center for Meningeal Melanocytoma

Genetic Tests for Meningeal Melanocytoma

Anatomical Context for Meningeal Melanocytoma

MalaCards organs/tissues related to Meningeal Melanocytoma:

40
Brain, Pituitary, Liver, Pineal, Skin, Spinal Cord, Temporal Lobe

Publications for Meningeal Melanocytoma

Articles related to Meningeal Melanocytoma:

(show top 50) (show all 142)
# Title Authors PMID Year
1
Primary pigmented meningeal melanocytoma originating in Meckel cave in a patient with carney complex: A case report. 61
32011473 2020
2
A Rapidly Growing Cervical Meningeal Melanocytoma with a Dumbbell-Shaped Extension. 61
31678313 2019
3
[Meningeal melanoma arising from a preexisting meningeal melanocytoma: A clinical, pathological and cytogenetic study about one case]. 61
30824318 2019
4
8-Year Follow-up for Woman with Spinal Meningeal Melanocytoma in S1 Nerve Root: Case Report and Literature Review. 61
31426249 2019
5
Meningeal Melanocytoma Associated with Nevus of Ota: Analysis of Twelve Reported Cases. 61
30904806 2019
6
Usefulness of Neuromelanin Sensitive MRI for En Plaque Meningeal Melanocytoma Involving the Cavernous Sinus: A Case Report. 61
31016099 2019
7
Intracranial meningeal melanocytoma diagnosed using an interdisciplinary approach: a case report and review of the literature. 61
29941032 2018
8
Primary Meningeal Melanocytoma in Sellar Region, Simulating a Nonfunctioning Pituitary Adenoma: Case Report and Literature Review. 61
29382618 2018
9
Primary meningeal melanocytoma of the cerebellopontine angle associated with ipsilateral nevus of Ota: A case report. 61
30613434 2018
10
Spinal meningeal melanocytoma in a 5-year-old child: a case report and review of literature. 61
29780233 2018
11
[Meningeal melanocytoma: aggressive evolution of a benign tumor: about 2 cases]. 61
30100965 2018
12
Amelanotic melanocytoma of the sella mimicking pituitary adenoma. 61
28853696 2017
13
[Melanocytoma and meningeal melanocytosis, similar but different lesions]. 61
28126183 2017
14
Diagnostic Clue of Meningeal Melanocytoma: Case Report and Review of Literature. 61
28120582 2017
15
Supratentorial intermediate grade meningeal melanocytoma with intratumoral bleed in the background of neurocutaneous melanosis: Report of an unusual case and review of literature. 61
28413547 2017
16
Orbital meningeal melanocytoma: Histological, immunohistochemical and molecular characterization of a case and review of the literature. 61
27499153 2016
17
Primary scattered multifocal melanocytomas in spinal canal mimicking neurofibromatosis. 61
26970601 2016
18
The GNAQ in the haystack: intramedullary meningeal melanocytoma of intermediate grade at T9-10 in a 58-year-old woman. 61
26544768 2016
19
Primary meningeal melanocytoma mimicking a nonfunctioning pituitary adenoma. 61
26857865 2016
20
Spinal meningeal melanocytomas: clinical manifestations, radiological and pathological characteristics, and surgical outcomes. 61
26940907 2016
21
Squash cytopathology of primary meningeal melanocytoma. 61
26755006 2016
22
Unusual lesions of the mediastinum. 61
26664161 2015
23
Primary meningeal melanocytoma of the sellar region: review of the literature and differential diagnosis with special reference to angiographical features. 61
25583147 2015
24
Sudden Death and Primary Leptomeningeal Melanocytosis: A Case Report With an Autopsy Diagnosis. 61
26266890 2015
25
Primary Meningeal Melanocytoma in the Left Temporal Lobe Associated with Nevus Ota: a Case Report and Review of the Literature. 61
25862111 2015
26
Intermediate-grade meningeal melanocytoma associated with nevus of Ota: a case report and review of the literature. 61
25933209 2015
27
Cerebellar meningeal melanocytoma associated with nevus of Ota: An extremely rare case. 61
26259856 2015
28
Meningeal melanocytoma of the middle cranial fossa (the Meckel's cave). 61
25947998 2015
29
A case report on intermediate-grade malignant meningeal melanocytoma with elevated cell proliferation index. 61
26617913 2015
30
Cervical Spinal Meningeal Melanocytoma Presenting as Intracranial Superficial Siderosis. 61
26770862 2015
31
[Multifocal meningeal melanocytoma with repeated recurrence: report of a case]. 61
25567599 2014
32
Primary ventral foramen magnum meningeal melanocytoma. 61
24823756 2014
33
Meningeal melanocytoma: case report and literature review. 61
24791361 2014
34
Intramedullary melanocytoma of thoracic spine: A rare case report. 61
24891889 2014
35
Spinal meningeal melanocytoma with benign histology showing leptomeningeal spread: case report. 61
23690716 2013
36
Unusual tonsillar herniation in meningeal melanocytoma: a case report. 61
23408465 2012
37
MR imaging findings of the intraspinal meningeal melanocytoma: correlation with histopathologic findings. 61
22442042 2012
38
Primary meningeal melanocytoma of the anterior cranial fossa: a case report and review of the literature. 61
22759717 2012
39
Primary meningeal melanocytoma located in foramen magnum: a case report and review of the literatures. 61
22770412 2012
40
Multifocal spinal meningeal melanocytoma: an illustrated case review. 61
23208918 2012
41
Multifocal meningeal melanocytoma of the conus medullaris. 61
21887493 2011
42
[Meningeal melanocytoma with malignant behaviour]. 61
21474212 2011
43
Meningeal melanocytoma of the cerebellopontine angle as the unusual cause of superficial siderosis. 61
21207224 2011
44
Intracranial meningeal melanocytoma associated with nevus of Ota. 61
21924617 2011
45
[A case of meningeal melanocytoma in the cerebellopontine angle]. 61
21873740 2011
46
Malignant transformation of intracranial meningeal melanocytoma. Case report and review of the literature. 61
21062362 2011
47
Spinal meningeal melanocytoma. 61
22347335 2011
48
[Meningeal melanocytoma with nevus fuscoceruleus ophthalmomaxillaris: report of a case]. 61
21575395 2011
49
Spinal meningeal melanocytoma in the S-1 nerve root sheath with paraspinal extension mimicking schwannoma. 61
21492734 2011
50
Spinal meningeal melanocytoma: A rare meningeal tumor. 61
21264144 2010

Variations for Meningeal Melanocytoma

Expression for Meningeal Melanocytoma

Search GEO for disease gene expression data for Meningeal Melanocytoma.

Pathways for Meningeal Melanocytoma

GO Terms for Meningeal Melanocytoma

Cellular components related to Meningeal Melanocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heterotrimeric G-protein complex GO:0005834 8.62 GNAQ GNA11

Biological processes related to Meningeal Melanocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 action potential GO:0001508 9.32 GNAQ GNA11
2 G protein-coupled acetylcholine receptor signaling pathway GO:0007213 9.26 GNAQ GNA11
3 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.16 GNAQ GNA11
4 phototransduction, visible light GO:0007603 8.96 GNAQ GNA11
5 entrainment of circadian clock GO:0009649 8.62 GNAQ GNA11

Molecular functions related to Meningeal Melanocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein beta/gamma-subunit complex binding GO:0031683 9.16 GNAQ GNA11
2 guanyl nucleotide binding GO:0019001 8.96 GNAQ GNA11
3 type 2A serotonin receptor binding GO:0031826 8.62 GNAQ GNA11

Sources for Meningeal Melanocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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