MCID: MNN001
MIFTS: 38

Meningeal Melanocytoma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Meningeal Melanocytoma

MalaCards integrated aliases for Meningeal Melanocytoma:

Name: Meningeal Melanocytoma 12 58 15 17 71
Leptomeningeal Melanocytoma 12
Melanocytoma of Meninges 12

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:5900
NCIt 50 C4662
SNOMED-CT 67 128730009
UMLS via Orphanet 72 C1266113
Orphanet 58 ORPHA252046
UMLS 71 C1266113

Summaries for Meningeal Melanocytoma

MalaCards based summary : Meningeal Melanocytoma, also known as leptomeningeal melanocytoma, is related to melanomatosis and neurilemmoma, and has symptoms including vomiting, headache and neurologic symptoms. An important gene associated with Meningeal Melanocytoma is GNAQ (G Protein Subunit Alpha Q), and among its related pathways/superpathways are Neuroscience and LPA receptor mediated events. The drugs Donepezil and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include liver, spinal cord and pituitary, and related phenotype is integument.

Related Diseases for Meningeal Melanocytoma

Diseases related to Meningeal Melanocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 199)
# Related Disease Score Top Affiliating Genes
1 melanomatosis 30.4 MLANA GNAQ
2 neurilemmoma 30.3 S100B MUC1 ENO2
3 meningeal melanoma 30.1 MLANA GNAQ GNA11
4 diffuse meningeal melanocytosis 30.1 MLANA MIB1
5 neurofibroma 29.9 S100B MUC1 MLANA
6 mongolian spot 29.7 MLANA GNAQ GNA11
7 meningeal melanomatosis 29.6 MLANA GNAQ GNA11
8 neuroma 29.6 S100B MUC1 ENO2
9 melanoma, uveal 29.5 S100B MLANA GNAQ GNA11
10 hemangioma 29.3 GNAQ GNA11 ENO2
11 skin melanoma 29.3 S100B MLANA GNAQ GNA11
12 meningioma, familial 10.6
13 spinal meningioma 10.6
14 secretory meningioma 10.6
15 lymphoplasmacyte-rich meningioma 10.6
16 nevus of ota 10.4
17 melanoma 10.4
18 rare tumor 10.4
19 siderosis 10.3
20 superficial siderosis 10.3
21 sclerosing perineurioma 10.2 S100B MUC1
22 perineurioma 10.2 S100B MUC1
23 localized hypertrophic neuropathy 10.2 S100B MUC1
24 reticular perineurioma 10.2 S100B MUC1
25 aggressive digital papillary adenocarcinoma 10.2 S100B MUC1
26 cerebral primitive neuroectodermal tumor 10.2 S100B MUC1
27 non-functioning pituitary adenoma 10.2 S100B MUC1
28 functioning pituitary adenoma 10.2 S100B MUC1
29 cutaneous leiomyosarcoma 10.2 S100B MUC1
30 syringocystadenoma papilliferum 10.2 S100B MUC1
31 intraneural perineurioma 10.2 S100B MUC1
32 dowling-degos disease 1 10.2
33 melanosis, neurocutaneous 10.2
34 pituitary adenoma 10.2
35 tièche-jadassohn nevus 10.2
36 chordoid meningioma 10.2 S100B MUC1
37 anaplastic ependymoma 10.2 S100B MUC1
38 polymorphous low-grade adenocarcinoma 10.2 S100B MUC1
39 eccrine porocarcinoma 10.2 S100B MUC1
40 chordoid glioma 10.2 S100B MUC1
41 dendritic cell tumor 10.2 S100B MUC1
42 fibrous meningioma 10.2 S100B MUC1
43 spiradenoma 10.2 S100B MUC1
44 spindle cell rhabdomyosarcoma 10.2 S100B MUC1
45 monophasic synovial sarcoma 10.2 S100B MUC1
46 clear cell meningioma 10.2 S100B MUC1
47 syringoma 10.2 S100B MUC1
48 cellular ependymoma 10.2 S100B MUC1
49 myxopapillary ependymoma 10.2 S100B MUC1
50 myxoid chondrosarcoma 10.2 S100B MUC1

Graphical network of the top 20 diseases related to Meningeal Melanocytoma:



Diseases related to Meningeal Melanocytoma

Symptoms & Phenotypes for Meningeal Melanocytoma

UMLS symptoms related to Meningeal Melanocytoma:


vomiting, headache, neurologic symptoms

MGI Mouse Phenotypes related to Meningeal Melanocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.02 GNA11 GNAQ MIB1 MLANA S100B

Drugs & Therapeutics for Meningeal Melanocytoma

Drugs for Meningeal Melanocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Donepezil Approved Phase 3 120014-06-4 3152
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
3 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
4 Neurotransmitter Agents Phase 3
5 Cholinesterase Inhibitors Phase 3
6 Cholinergic Agents Phase 3
7 Anesthetics Phase 3
8 Narcotics Phase 3
9 Liver Extracts Phase 3
10 Cola Phase 3
11 Analgesics, Opioid Phase 3
12 Analgesics Phase 3
13 Anesthetics, Intravenous Phase 3
14 Anesthetics, General Phase 3
15
Verteporfin Approved, Investigational Phase 1 129497-78-5
16
Trioxsalen Approved Phase 1 3902-71-4 5585
17
Miconazole Approved, Investigational, Vet_approved Phase 1 22916-47-8 4189
18
Sirolimus Approved, Investigational Phase 1 53123-88-9 5284616 6436030
19
Clotrimazole Approved, Vet_approved Phase 1 23593-75-1 2812
20 Dihematoporphyrin Ether Phase 1
21 Dermatologic Agents Phase 1
22 Photosensitizing Agents Phase 1
23 Antifungal Agents Phase 1
24 Antibiotics, Antitubercular Phase 1
25 Immunosuppressive Agents Phase 1
26 Dialysis Solutions Phase 1
27 Anti-Infective Agents Phase 1
28 Immunologic Factors Phase 1
29 Anti-Bacterial Agents Phase 1
30 Mitogens Phase 1
31
Temozolomide Approved, Investigational 85622-93-1 5394

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Double Blind, Placebo Controlled Study of Donepezil in the Irradiated Brain Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
2 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Photodynamic Therapy For Childhood Brain Tumors, A Phase I Study Unknown status NCT00002647 Phase 1 verteporfin
4 A Pilot Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors Completed NCT00784914 Phase 1 temsirolimus
5 Temozolomide Induced Changes in Semen/Sperm Analysis in Men With Newly Diagnosed, Progressive or Recurrent Primary Malignant Brain Tumors Completed NCT00499798
6 Identification of Genes Involved in the Pathogenesis of Gliomas by Transcriptome Analysis Completed NCT00967200

Search NIH Clinical Center for Meningeal Melanocytoma

Genetic Tests for Meningeal Melanocytoma

Anatomical Context for Meningeal Melanocytoma

MalaCards organs/tissues related to Meningeal Melanocytoma:

40
Liver, Spinal Cord, Pituitary, Temporal Lobe, Pineal

Publications for Meningeal Melanocytoma

Articles related to Meningeal Melanocytoma:

(show top 50) (show all 148)
# Title Authors PMID Year
1
Recurrent spinal meningeal melanocytoma at lumbar spine level: a case report. 61
33410365 2021
2
Definitive radiotherapy for meningeal brainstem melanocytoma: a case report. 61
33356599 2020
3
Identification of a Novel BRCA1 Alteration in Recurrent Melanocytoma Resulting in Increased Proliferation. 61
32974655 2020
4
Parietal Convexity Meningeal Melanocytoma: Radiologic-Pathologic Correlation. 61
33213533 2020
5
C6-T1 Intradural Extramedullary Ventral Meningeal Melanocytoma Resected Via Anterior Corpectomy with Reconstruction. 61
32251820 2020
6
A Rapidly Growing Cervical Meningeal Melanocytoma with a Dumbbell-Shaped Extension. 61
31678313 2020
7
Meningeal Melanocytoma Occurring at Epidural Region of the Cervical Spine. 61
33195866 2020
8
Primary pigmented meningeal melanocytoma originating in Meckel cave in a patient with carney complex: A case report. 61
32011473 2020
9
8-Year Follow-up for Woman with Spinal Meningeal Melanocytoma in S1 Nerve Root: Case Report and Literature Review. 61
31426249 2019
10
[Meningeal melanoma arising from a preexisting meningeal melanocytoma: A clinical, pathological and cytogenetic study about one case]. 61
30824318 2019
11
Meningeal Melanocytoma Associated with Nevus of Ota: Analysis of Twelve Reported Cases. 61
30904806 2019
12
Usefulness of Neuromelanin Sensitive MRI for En Plaque Meningeal Melanocytoma Involving the Cavernous Sinus: A Case Report. 61
31016099 2019
13
Intracranial meningeal melanocytoma diagnosed using an interdisciplinary approach: a case report and review of the literature. 61
29941032 2018
14
Primary Meningeal Melanocytoma in Sellar Region, Simulating a Nonfunctioning Pituitary Adenoma: Case Report and Literature Review. 61
29382618 2018
15
Primary meningeal melanocytoma of the cerebellopontine angle associated with ipsilateral nevus of Ota: A case report. 61
30613434 2018
16
Spinal meningeal melanocytoma in a 5-year-old child: a case report and review of literature. 61
29780233 2018
17
[Meningeal melanocytoma: aggressive evolution of a benign tumor: about 2 cases]. 61
30100965 2018
18
Amelanotic melanocytoma of the sella mimicking pituitary adenoma. 61
28853696 2017
19
[Melanocytoma and meningeal melanocytosis, similar but different lesions]. 61
28126183 2017
20
Diagnostic Clue of Meningeal Melanocytoma: Case Report and Review of Literature. 61
28120582 2017
21
Supratentorial intermediate grade meningeal melanocytoma with intratumoral bleed in the background of neurocutaneous melanosis: Report of an unusual case and review of literature. 61
28413547 2017
22
Orbital meningeal melanocytoma: Histological, immunohistochemical and molecular characterization of a case and review of the literature. 61
27499153 2016
23
Primary scattered multifocal melanocytomas in spinal canal mimicking neurofibromatosis. 61
26970601 2016
24
The GNAQ in the haystack: intramedullary meningeal melanocytoma of intermediate grade at T9-10 in a 58-year-old woman. 61
26544768 2016
25
Primary meningeal melanocytoma mimicking a nonfunctioning pituitary adenoma. 61
26857865 2016
26
Spinal meningeal melanocytomas: clinical manifestations, radiological and pathological characteristics, and surgical outcomes. 61
26940907 2016
27
Squash cytopathology of primary meningeal melanocytoma. 61
26755006 2016
28
Unusual lesions of the mediastinum. 61
26664161 2015
29
Primary meningeal melanocytoma of the sellar region: review of the literature and differential diagnosis with special reference to angiographical features. 61
25583147 2015
30
Sudden Death and Primary Leptomeningeal Melanocytosis: A Case Report With an Autopsy Diagnosis. 61
26266890 2015
31
Primary Meningeal Melanocytoma in the Left Temporal Lobe Associated with Nevus Ota: a Case Report and Review of the Literature. 61
25862111 2015
32
Intermediate-grade meningeal melanocytoma associated with nevus of Ota: a case report and review of the literature. 61
25933209 2015
33
Cerebellar meningeal melanocytoma associated with nevus of Ota: An extremely rare case. 61
26259856 2015
34
Meningeal melanocytoma of the middle cranial fossa (the Meckel's cave). 61
25947998 2015
35
A case report on intermediate-grade malignant meningeal melanocytoma with elevated cell proliferation index. 61
26617913 2015
36
Cervical Spinal Meningeal Melanocytoma Presenting as Intracranial Superficial Siderosis. 61
26770862 2015
37
[Multifocal meningeal melanocytoma with repeated recurrence: report of a case]. 61
25567599 2014
38
Primary ventral foramen magnum meningeal melanocytoma. 61
24823756 2014
39
Meningeal melanocytoma: case report and literature review. 61
24791361 2014
40
Intramedullary melanocytoma of thoracic spine: A rare case report. 61
24891889 2014
41
Spinal meningeal melanocytoma with benign histology showing leptomeningeal spread: case report. 61
23690716 2013
42
Unusual tonsillar herniation in meningeal melanocytoma: a case report. 61
23408465 2012
43
MR imaging findings of the intraspinal meningeal melanocytoma: correlation with histopathologic findings. 61
22442042 2012
44
Primary meningeal melanocytoma of the anterior cranial fossa: a case report and review of the literature. 61
22759717 2012
45
Primary meningeal melanocytoma located in foramen magnum: a case report and review of the literatures. 61
22770412 2012
46
Multifocal spinal meningeal melanocytoma: an illustrated case review. 61
23208918 2012
47
[Meningeal melanocytoma with malignant behaviour]. 61
21474212 2011
48
Multifocal meningeal melanocytoma of the conus medullaris. 61
21887493 2011
49
Meningeal melanocytoma of the cerebellopontine angle as the unusual cause of superficial siderosis. 61
21207224 2011
50
Intracranial meningeal melanocytoma associated with nevus of Ota. 61
21924617 2011

Variations for Meningeal Melanocytoma

Expression for Meningeal Melanocytoma

Search GEO for disease gene expression data for Meningeal Melanocytoma.

Pathways for Meningeal Melanocytoma

GO Terms for Meningeal Melanocytoma

Cellular components related to Meningeal Melanocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heterotrimeric G-protein complex GO:0005834 8.62 GNAQ GNA11

Biological processes related to Meningeal Melanocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.32 GNAQ GNA11
2 action potential GO:0001508 9.26 GNAQ GNA11
3 G protein-coupled acetylcholine receptor signaling pathway GO:0007213 9.16 GNAQ GNA11
4 phototransduction, visible light GO:0007603 8.96 GNAQ GNA11
5 entrainment of circadian clock GO:0009649 8.62 GNAQ GNA11

Molecular functions related to Meningeal Melanocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor binding GO:0001664 9.26 GNAQ GNA11
2 G-protein beta/gamma-subunit complex binding GO:0031683 9.16 GNAQ GNA11
3 guanyl nucleotide binding GO:0019001 8.96 GNAQ GNA11
4 type 2A serotonin receptor binding GO:0031826 8.62 GNAQ GNA11

Sources for Meningeal Melanocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....