MCID: MNN010
MIFTS: 31

Meningeal Melanoma

Categories: Cancer diseases, Neuronal diseases, Skin diseases

Aliases & Classifications for Meningeal Melanoma

MalaCards integrated aliases for Meningeal Melanoma:

Name: Meningeal Melanoma 12 15
Melanoma of the Leptomeninges 12
Leptomeningeal Melanoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:6085
NCIt 50 C5317
SNOMED-CT 67 726420002
UMLS 70 C1334386

Summaries for Meningeal Melanoma

MalaCards based summary : Meningeal Melanoma, also known as melanoma of the leptomeninges, is related to meningeal melanocytoma and meningeal melanomatosis, and has symptoms including vomiting, headache and neurologic symptoms. An important gene associated with Meningeal Melanoma is GNAQ (G Protein Subunit Alpha Q), and among its related pathways/superpathways are CCR5 Pathway in Macrophages and Pathways in cancer. Affiliated tissues include spinal cord and pineal, and related phenotypes are integument and craniofacial

Related Diseases for Meningeal Melanoma

Diseases related to Meningeal Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 meningeal melanocytoma 29.6 MLANA GNAQ GNA11
2 meningeal melanomatosis 29.0 NRAS MLANA GNAQ GNA11
3 melanoma 29.0 TYR NRAS MLANA GNAQ GNA11
4 melanomatosis 28.4 TYR NRAS MLANA GTPBP4 GNAQ
5 primary melanoma of the central nervous system 11.1
6 phakomatosis cesioflammea 10.1 GNAQ GNA11
7 hypocalciuric hypercalcemia, familial, type ii 10.0 GNAQ GNA11
8 weber syndrome 10.0 GNAQ GNA11
9 sturge-weber syndrome 10.0 GNAQ GNA11
10 nevus of ota 10.0
11 familial hypocalciuric hypercalcemia 10.0 GNAQ GNA11
12 sensory organ benign neoplasm 10.0 NRAS MLANA
13 nevus, epidermal 10.0 NRAS GNAQ
14 dowling-degos disease 1 9.8
15 melanosis, neurocutaneous 9.8
16 chronic meningitis 9.8
17 lactic acidosis 9.8
18 neurofibromatosis 9.8
19 intracranial hypertension 9.8
20 meningitis 9.8
21 diffuse leptomeningeal melanocytosis 9.8
22 rare tumor 9.8
23 hypomelanosis of ito 9.8 NRAS GNAQ GNA11
24 melanocytic nevus syndrome, congenital 9.8 TYR NRAS
25 mucosal melanoma 9.8 NRAS GNAQ GNA11
26 ocular melanoma 9.8 NRAS GNAQ GNA11
27 ciliary body cancer 9.8 TYR MLANA
28 conjunctival nevus 9.8 NRAS MLANA GNAQ
29 melanoacanthoma 9.8 TYR MLANA
30 halo nevi 9.8 TYR MLANA
31 sarcomatoid transitional cell carcinoma 9.8 TYR MLANA
32 spinal cord melanoma 9.8 TYR MLANA
33 diffuse meningeal melanocytosis 9.8 TYR MLANA
34 orofacial cleft 8 9.7 TYR MLANA
35 mongolian spot 9.7 MLANA GNAQ GNA11
36 malignant anus melanoma 9.7 NRAS MLANA GNA11
37 amelanotic melanoma 9.7 TYR MLANA
38 keratosis, seborrheic 9.7 TYR MLANA
39 ocular cancer 9.7 MLANA GNAQ GNA11
40 angiomyolipoma 9.7 TYR MLANA
41 clear cell sarcoma 9.7 TYR MLANA
42 skin benign neoplasm 9.7 TYR MLANA
43 adrenal carcinoma 9.6 NRAS MLANA
44 neurofibroma 9.6 TYR MLANA
45 vitiligo-associated multiple autoimmune disease susceptibility 1 9.6 TYR MLANA
46 ocular albinism 9.5 TYR MLANA
47 malignant dermis tumor 9.5 NRAS MLANA GNAQ GNA11
48 malignant skin fibrous histiocytoma 9.5 NRAS MLANA GNAQ GNA11
49 epithelioid cell melanoma 9.5 TYR MLANA GNA11
50 vulvar melanoma 9.5 NRAS MLANA GNAQ GNA11

Graphical network of the top 20 diseases related to Meningeal Melanoma:



Diseases related to Meningeal Melanoma

Symptoms & Phenotypes for Meningeal Melanoma

UMLS symptoms related to Meningeal Melanoma:


vomiting; headache; neurologic symptoms

MGI Mouse Phenotypes related to Meningeal Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.63 GNA11 GNAQ GTPBP4 MLANA NRAS TYR
2 craniofacial MP:0005382 9.56 GNA11 GNAQ NRAS TYR
3 limbs/digits/tail MP:0005371 9.26 GNA11 GNAQ NRAS TYR
4 pigmentation MP:0001186 9.1 GNA11 GNAQ GTPBP4 MLANA NRAS TYR

Drugs & Therapeutics for Meningeal Melanoma

Search Clinical Trials , NIH Clinical Center for Meningeal Melanoma

Genetic Tests for Meningeal Melanoma

Anatomical Context for Meningeal Melanoma

MalaCards organs/tissues related to Meningeal Melanoma:

40
Spinal Cord, Pineal

Publications for Meningeal Melanoma

Articles related to Meningeal Melanoma:

(show top 50) (show all 63)
# Title Authors PMID Year
1
Multifocal primary amelanotic meningeal melanomas mimicking lymphoma: a case report and literature review. 61
33054413 2020
2
Bevacizumab treatment of meningeal melanoma metastases. 61
31915016 2020
3
Primary diffuse meningeal melanomatosis - a rare form of meningeal melanoma: case report. 61
31690266 2019
4
Primary intracranial meningeal melanoma mimicking chronic meningitis: A case report. 61
30497968 2019
5
[Meningeal melanoma arising from a preexisting meningeal melanocytoma: A clinical, pathological and cytogenetic study about one case]. 61
30824318 2019
6
Amelanotic Meningeal Melanoma with Leptomeningeal Dissemination: A Case Report and Systematic Literature Review. 61
30404049 2019
7
The role of next-generation sequencing in the differential diagnosis of composite neoplasms. 61
29958927 2018
8
[Supratentorial Meningeal Melanoma with Nevus of Ota:A Case Report]. 61
29449519 2018
9
[Melanocytoma and meningeal melanocytosis, similar but different lesions]. 61
28126183 2017
10
Primary Melanoma of the Leptomeninges with BAP1 Expression-Loss in the Setting of a Nevus of Ota: A Clinical, Morphological and Genetic Study of 2 Cases. 61
26834043 2016
11
Primary meningeal melanoma with cerebrospinal fluid dissemination mimicking neurofibromatosis type 2. 61
26200063 2015
12
A case report on intermediate-grade malignant meningeal melanocytoma with elevated cell proliferation index. 61
26617913 2015
13
Meningeal Melanocytes in the Mouse: Distribution and Dependence on Mitf. 61
26635543 2015
14
Liposomal cytarabine in neoplastic meningitis from primary brain tumors: a single institutional experience. 61
23525755 2013
15
Primitive cerebral melanoma: a diagnostic and management challenge. About 2 cases. 61
22169116 2012
16
[Primary amelanotic meningeal melanomatosis]. 61
22450762 2012
17
Clinical characteristics and risk of melanoma development from giant congenital melanocytic naevi in Korea: a nationwide retrospective study. 61
21923752 2012
18
Staged transcrusal and transsphenoidal endoscopic resection of an atypical clival melanoma: a case report and literature review. 61
21358999 2010
19
Central lactic acidosis, hyperventilation, and respiratory alkalosis: leading clinical features in a 3-year-old boy with malignant meningeal melanoma. 61
17534659 2008
20
[Clinical and pathologic features of melanocytic lesion of the central nervous system]. 61
17767073 2007
21
Large primary meningeal melanoma in an adult patient with neurocutaneous melanosis. 61
17382464 2007
22
Primary leptomeningeal melanoma in a child. 61
11516618 2001
23
Leptomeningeal melanoma and Creutzfeldt-Jakob disease in a patient with chronic lymphocytic leukaemia. 61
10476052 1999
24
Periorbital cellular blue nevus leading to orbitopalpebral and intracranial melanoma. 61
9818603 1998
25
Primary pineal and meningeal malignant melanomatosis. 61
18639049 1998
26
Malignant meningeal melanoma. 61
10935858 1998
27
Intracranial meningeal melanocytoma: CT and MRI. 61
9406208 1997
28
Melanocytoma of the cavernous sinus: CT and MR findings. 61
8791920 1996
29
[Late abdominal metastases of primary meningeal melanoma. Contribution of MRI]. 61
8151554 1994
30
Meningeal melanoma associated with nevus of Ota: case report and review. 61
8324963 1993
31
Primary leptomeningeal melanoma: an unusually aggressive tumor in childhood. 61
8492846 1993
32
[Malignant melanoma of the meninges--MR and CT diagnosis]. 61
2154016 1990
33
[Meningeal metastasis of malignant melanoma]. 61
2772537 1989
34
[Diffuse meningeal melanoma]. 61
2629900 1989
35
Primary meningeal melanoma. 61
2706127 1989
36
[Melanomatous meningitis. Apropos of 3 cases]. 61
2688521 1989
37
Primary meningeal melanoma. 61
3394553 1988
38
[Primary melanoma of the leptomeninges. An optical and ultrastructural study]. 61
3326541 1987
39
[Primary diffuse meningeal melanoma]. 61
3689092 1987
40
Congenital neurocutaneous melanosis with metastatic orbital malignant melanoma. 61
3808623 1986
41
Neurocutaneous melanosis with malignant melanoma of the leptomeninges. 61
21164250 1985
42
Computed tomography of primary melanoma of the leptomeninges: case reports. 61
4053661 1985
43
Meningeal melanocytoma of Meckel's cave associated with ipsilateral Ota's nevus. 61
6850510 1983
44
Primary melanoma of the leptomeninges. A report of two cases. 61
7173972 1982
45
Primary dural melanoma: a clinical and morphological study. 61
7322339 1981
46
Primary intracranial melanoma presenting as a suprasellar tumor. 61
7413039 1980
47
[Mélanose neuro-cutanée with malignant melanoma of the leptomeninges - an autopsy case]. 61
748616 1978
48
[Primary malignant melanoma of the leptomeninges of the spinal cord]. 61
726342 1978
49
Primary cerebral melanomas. Report of six cases and a review of the literature. 61
899787 1977
50
Neurocutaneous melanosis. Report of a case and review of the literature. 61
835391 1977

Variations for Meningeal Melanoma

Expression for Meningeal Melanoma

Search GEO for disease gene expression data for Meningeal Melanoma.

Pathways for Meningeal Melanoma

Pathways related to Meningeal Melanoma according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.53 NRAS GNAQ GNA11
2 12.49 NRAS GNAQ GNA11
3
Show member pathways
12.48 NRAS GNAQ GNA11
4
Show member pathways
12.42 NRAS GNAQ GNA11
5
Show member pathways
12.33 NRAS GNAQ GNA11
6
Show member pathways
12.33 TYR NRAS GNAQ GNA11
7
Show member pathways
12.29 NRAS GNAQ GNA11
8
Show member pathways
12.09 NRAS GNAQ GNA11
9 11.64 GNAQ GNA11
10 11.61 GNAQ GNA11
11
Show member pathways
11.61 NRAS GNAQ GNA11
12 11.56 GNAQ GNA11
13 11.38 GNAQ GNA11
14 11.38 NRAS GNAQ GNA11
15 11.28 NRAS GNAQ GNA11
16 11.24 GNAQ GNA11
17 11.09 GNAQ GNA11
18 11.02 GNAQ GNA11
19 10.96 GNAQ GNA11
20 10.94 NRAS GNAQ GNA11
21 10.71 NRAS GNAQ
22 10.58 NRAS GNAQ GNA11
23
Show member pathways
10.57 GNAQ GNA11

GO Terms for Meningeal Melanoma

Cellular components related to Meningeal Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome GO:0042470 9.16 TYR MLANA
2 photoreceptor outer segment GO:0001750 8.96 GNAQ GNA11
3 heterotrimeric G-protein complex GO:0005834 8.62 GNAQ GNA11

Biological processes related to Meningeal Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.32 GNAQ GNA11
2 action potential GO:0001508 9.26 GNAQ GNA11
3 G protein-coupled acetylcholine receptor signaling pathway GO:0007213 9.16 GNAQ GNA11
4 phototransduction, visible light GO:0007603 8.96 GNAQ GNA11
5 entrainment of circadian clock GO:0009649 8.62 GNAQ GNA11

Molecular functions related to Meningeal Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTP binding GO:0005525 9.46 NRAS GTPBP4 GNAQ GNA11
2 G protein-coupled receptor binding GO:0001664 9.37 GNAQ GNA11
3 G-protein beta/gamma-subunit complex binding GO:0031683 9.32 GNAQ GNA11
4 guanyl nucleotide binding GO:0019001 9.26 GNAQ GNA11
5 type 2A serotonin receptor binding GO:0031826 8.96 GNAQ GNA11
6 GTPase activity GO:0003924 8.92 NRAS GTPBP4 GNAQ GNA11

Sources for Meningeal Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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