MCID: MNN008
MIFTS: 40

Meningeal Melanomatosis

Categories: Cancer diseases, Neuronal diseases, Skin diseases

Aliases & Classifications for Meningeal Melanomatosis

MalaCards integrated aliases for Meningeal Melanomatosis:

Name: Meningeal Melanomatosis 12 15 73
Leptomeningeal Melanomatosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8243
NCIt 50 C6891
UMLS 73 C1266114

Summaries for Meningeal Melanomatosis

MalaCards based summary : Meningeal Melanomatosis, also known as leptomeningeal melanomatosis, is related to melanomatosis and skin melanoma, and has symptoms including vomiting, headache and neurologic symptoms. An important gene associated with Meningeal Melanomatosis is CWC22 (CWC22 Spliceosome Associated Protein Homolog), and among its related pathways/superpathways are DAG and IP3 signaling and Phospholipase-C Pathway. Affiliated tissues include skin, bone and lung, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Meningeal Melanomatosis

Diseases related to Meningeal Melanomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 melanomatosis 30.4 CDKN2A CWC22 GNA11 GNAQ HRAS NRAS
2 skin melanoma 30.0 CDKN2A NRAS TP53
3 diffuse leptomeningeal melanocytosis 11.3
4 melanosis, neurocutaneous 10.4
5 melanoma 10.3
6 meningitis 10.3
7 melanocytic nevus syndrome, congenital 10.3 HRAS NRAS
8 myelodysplastic myeloproliferative cancer 10.3 HRAS NRAS
9 acneiform dermatitis 10.3 HRAS NRAS
10 phakomatosis cesioflammea 10.3 GNA11 GNAQ
11 intraocular melanoma 10.2 GNA11 GNAQ
12 giant congenital nevus 10.2 HRAS NRAS
13 benign struma ovarii 10.2 HRAS NRAS
14 schimmelpenning-feuerstein-mims syndrome 10.2 HRAS NRAS
15 ovarian melanoma 10.2 HRAS NRAS
16 marcus gunn phenomenon 10.2 HRAS NRAS
17 malignant struma ovarii 10.2 HRAS NRAS
18 lymphoepithelioma-like carcinoma 10.2 ENO2 PDCD1
19 mongolian spot 10.2 ENO2 GNAQ
20 conjunctival cancer 10.2 GNA11 GNAQ NRAS
21 bone benign neoplasm 10.2 ENO2 SYP
22 papillary ependymoma 10.2 ENO2 SYP
23 gastric squamous cell carcinoma 10.2 ENO2 SYP
24 conventional fibrosarcoma 10.2 ENO2 NRAS
25 prostate small cell carcinoma 10.2 ENO2 SYP
26 extraskeletal ewing sarcoma 10.2 ENO2 SYP
27 mucosal melanoma 10.2 GNA11 GNAQ NRAS
28 acral lentiginous melanoma 10.1 CDKN2A NRAS
29 carotid body cancer 10.1 ENO2 SYP
30 nodular malignant melanoma 10.1 GNAQ HRAS NRAS
31 fetal adenoma 10.1 HRAS NRAS
32 malignant ectomesenchymoma 10.1 ENO2 HRAS
33 ectomesenchymoma 10.1 ENO2 HRAS
34 malignant sertoli cell tumor 10.1 ENO2 SYP
35 urinary bladder small cell neuroendocrine carcinoma 10.1 ENO2 SYP
36 gallbladder adenoma 10.1 CDKN2A HRAS
37 auditory system cancer 10.1 ENO2 SYP
38 sinonasal undifferentiated carcinoma 10.1 ENO2 SYP
39 gallbladder small cell carcinoma 10.1 ENO2 SYP
40 pancreatic somatostatinoma 10.1 ENO2 SYP
41 cutaneous ganglioneuroma 10.1 ENO2 SYP
42 extrahepatic bile duct adenocarcinoma 10.1 ENO2 SYP
43 small cell carcinoma of the bladder 10.1 ENO2 SYP
44 papillary tumor of the pineal region 10.1 ENO2 SYP
45 patulous eustachian tube 10.1
46 sensory organ benign neoplasm 10.1 ENO2 SYP
47 orbital cancer 10.1 ENO2 SYP
48 middle ear adenoma 10.1 ENO2 SYP
49 pulmonary large cell neuroendocrine carcinoma 10.1 ENO2 SYP
50 clear cell ependymoma 10.1 ENO2 SYP

Graphical network of the top 20 diseases related to Meningeal Melanomatosis:



Diseases related to Meningeal Melanomatosis

Symptoms & Phenotypes for Meningeal Melanomatosis

UMLS symptoms related to Meningeal Melanomatosis:


vomiting, headache, neurologic symptoms

MGI Mouse Phenotypes related to Meningeal Melanomatosis:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.21 CDKN2A ENO2 GNA11 GNAQ HRAS NGF
2 growth/size/body region MP:0005378 10.21 B2M CDKN2A ENO2 GNA11 GNAQ HRAS
3 cardiovascular system MP:0005385 10.2 B2M CDKN2A GNA11 GNAQ HRAS NGF
4 homeostasis/metabolism MP:0005376 10.15 B2M CDKN2A GNA11 GNAQ HRAS NGF
5 endocrine/exocrine gland MP:0005379 10.13 B2M CDKN2A GNA11 GNAQ HRAS NRAS
6 mortality/aging MP:0010768 10.09 B2M CDKN2A GNA11 GNAQ HRAS NGF
7 integument MP:0010771 10.08 B2M CDKN2A GNA11 GNAQ HRAS NGF
8 nervous system MP:0003631 10.02 B2M CDKN2A ENO2 GNA11 GNAQ HRAS
9 craniofacial MP:0005382 10.01 ENO2 GNA11 GNAQ HRAS NRAS TP53
10 liver/biliary system MP:0005370 9.93 B2M CDKN2A GNA11 NRAS PDCD1 TP53
11 muscle MP:0005369 9.88 CDKN2A GNA11 GNAQ NGF PDCD1 TP53
12 neoplasm MP:0002006 9.85 B2M CDKN2A HRAS NRAS PDCD1 TP53
13 normal MP:0002873 9.8 GNA11 GNAQ HRAS NGF NRAS SYP
14 pigmentation MP:0001186 9.55 CDKN2A GNA11 GNAQ NRAS TP53
15 respiratory system MP:0005388 9.5 CDKN2A ENO2 GNA11 GNAQ HRAS PDCD1
16 skeleton MP:0005390 9.17 CDKN2A GNA11 GNAQ HRAS NRAS PDCD1

Drugs & Therapeutics for Meningeal Melanomatosis

Search Clinical Trials , NIH Clinical Center for Meningeal Melanomatosis

Genetic Tests for Meningeal Melanomatosis

Anatomical Context for Meningeal Melanomatosis

MalaCards organs/tissues related to Meningeal Melanomatosis:

41
Skin, Bone, Lung, Brain, Prostate, Cervix, Pineal

Publications for Meningeal Melanomatosis

Articles related to Meningeal Melanomatosis:

(show all 14)
# Title Authors Year
1
Primary Diffuse Leptomeningeal Melanomatosis of Spine: 18F-FDG PET Findings. ( 30516687 )
2018
2
NRASQ61K mutated diffuse leptomeningeal melanomatosis in an adult patient with a brief review of the so-called "forme fruste" of neurocutaneous melanosis. ( 30145692 )
2018
3
Diagnostic Difficulties in Primary Pauci-Melanotic Leptomeningeal Melanomatosis. ( 30231251 )
2018
4
Primary Diffuse Leptomeningeal Melanomatosis: Case Report and Review of the Literature. ( 30496931 )
2018
5
Meningeal melanomatosis following discontinuation of dabrafenib: implications for the maintenance of long-term complete remission. ( 28723725 )
2017
6
Meningeal melanomatosis: a challenge for timely diagnosis. ( 25648721 )
2015
7
F-18 fluorodeoxyglucose PET/CT and post hoc PET/MRI in a case of primary meningeal melanomatosis. ( 23483049 )
2013
8
A patient with meningeal melanomatosis treated for periodontal disease with a bone regeneration procedure and dental implants: clinical and behavioral management to support medical compliance. ( 24772265 )
2013
9
Primary malignant meningeal melanomatosis: a clinical, radiological and pathologic case study. ( 22141290 )
2011
10
Primary diffuse meningeal melanomatosis. ( 20220448 )
2010
11
Primary diffuse meningeal melanomatosis: radiologic-pathologic correlation. ( 12533338 )
2003
12
MR imaging of experimental meningeal melanomatosis in nude rats. ( 1460485 )
1992
13
Experimental meningeal melanomatosis. ( 2749474 )
1989
14
Primary meningeal melanomatosis: limitations of current diagnostic techniques. ( 6619899 )
1983

Variations for Meningeal Melanomatosis

Expression for Meningeal Melanomatosis

Search GEO for disease gene expression data for Meningeal Melanomatosis.

Pathways for Meningeal Melanomatosis

Pathways related to Meningeal Melanomatosis according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.97 GNA11 GNAQ HRAS NGF NRAS
2
Show member pathways
12.93 GNA11 HRAS NGF NRAS TP53
3
Show member pathways
12.88 GNA11 GNAQ HRAS NRAS TP53
4
Show member pathways
12.83 GNA11 GNAQ HRAS NGF NRAS TP53
5
Show member pathways
12.79 GNA11 GNAQ HRAS NGF NRAS TP53
6
Show member pathways
12.71 GNA11 HRAS NGF NRAS
7
Show member pathways
12.7 CDKN2A HRAS NGF NRAS TP53
8
Show member pathways
12.68 CDKN2A HRAS NRAS TP53
9 12.67 HRAS NGF NRAS TP53
10
Show member pathways
12.66 CDKN2A HRAS NRAS TP53
11
Show member pathways
12.63 GNAQ HRAS NGF NRAS
12
Show member pathways
12.63 GNA11 GNAQ HRAS NRAS
13
Show member pathways
12.61 HRAS NGF NRAS TP53
14
Show member pathways
12.58 B2M CDKN2A GNA11 GNAQ HRAS NRAS
15
Show member pathways
12.57 GNA11 GNAQ HRAS NGF NRAS
16 12.57 CDKN2A GNA11 GNAQ HRAS NRAS TP53
17
Show member pathways
12.52 GNA11 GNAQ HRAS NGF
18 12.47 ENO2 GNA11 GNAQ NGF SYP
19 12.4 CDKN2A HRAS NRAS TP53
20 12.33 CDKN2A HRAS NRAS TP53
21
Show member pathways
12.24 CDKN2A GNA11 GNAQ HRAS NRAS
22 12.2 CDKN2A HRAS NRAS TP53
23
Show member pathways
12.11 GNAQ HRAS NRAS
24
Show member pathways
12.08 HRAS NRAS TP53
25 12.08 CDKN2A HRAS NRAS TP53
26
Show member pathways
12.05 HRAS NRAS TP53
27
Show member pathways
12.04 HRAS NGF NRAS TP53
28 11.99 GNAQ HRAS NRAS
29 11.97 HRAS NRAS TP53
30
Show member pathways
11.94 GNA11 GNAQ HRAS
31
Show member pathways
11.92 GNA11 GNAQ HRAS
32 11.9 HRAS NRAS TP53
33 11.9 GNAQ HRAS NRAS TP53
34 11.89 GNAQ HRAS NRAS
35 11.88 GNAQ HRAS NRAS
36 11.87 CDKN2A HRAS NRAS TP53
37 11.84 CDKN2A HRAS TP53
38 11.82 CDKN2A HRAS NRAS TP53
39 11.65 GNA11 GNAQ HRAS NRAS
40 11.61 HRAS NRAS TP53
41 11.6 GNA11 GNAQ HRAS
42 11.59 HRAS NRAS TP53
43 11.58 GNA11 GNAQ HRAS NGF NRAS
44 11.49 CDKN2A HRAS NRAS TP53
45
Show member pathways
11.45 GNA11 GNAQ HRAS NRAS TP53
46 11.34 GNA11 GNAQ HRAS NRAS
47
Show member pathways
11.13 HRAS NRAS
48 11.07 HRAS NRAS
49 11.05 HRAS NRAS
50 11.05 CDKN2A TP53

GO Terms for Meningeal Melanomatosis

Biological processes related to Meningeal Melanomatosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.78 CDKN2A HRAS NGF TP53
2 positive regulation of gene expression GO:0010628 9.76 CDKN2A HRAS NGF TP53
3 cell cycle arrest GO:0007050 9.61 CDKN2A HRAS TP53
4 positive regulation of apoptotic process GO:0043065 9.56 CDKN2A NGF PDCD1 TP53
5 cellular senescence GO:0090398 9.52 CDKN2A HRAS
6 regulation of long-term neuronal synaptic plasticity GO:0048169 9.51 HRAS SYP
7 positive regulation of Ras protein signal transduction GO:0046579 9.49 HRAS NGF
8 action potential GO:0001508 9.4 GNA11 GNAQ
9 G protein-coupled acetylcholine receptor signaling pathway GO:0007213 9.37 GNA11 GNAQ
10 replicative senescence GO:0090399 9.32 CDKN2A TP53
11 phototransduction, visible light GO:0007603 9.16 GNA11 GNAQ
12 entrainment of circadian clock GO:0009649 8.96 GNA11 GNAQ
13 Ras protein signal transduction GO:0007265 8.92 CDKN2A HRAS NRAS TP53

Molecular functions related to Meningeal Melanomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTP binding GO:0005525 9.46 GNA11 GNAQ HRAS NRAS
2 G-protein beta/gamma-subunit complex binding GO:0031683 9.32 GNA11 GNAQ
3 guanyl nucleotide binding GO:0019001 9.26 GNA11 GNAQ
4 GTPase activity GO:0003924 9.26 GNA11 GNAQ HRAS NRAS
5 type 2A serotonin receptor binding GO:0031826 8.62 GNA11 GNAQ

Sources for Meningeal Melanomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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