MCID: MNN008
MIFTS: 38

Meningeal Melanomatosis

Categories: Cancer diseases, Neuronal diseases, Skin diseases

Aliases & Classifications for Meningeal Melanomatosis

MalaCards integrated aliases for Meningeal Melanomatosis:

Name: Meningeal Melanomatosis 12 15 73
Leptomeningeal Melanomatosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8243
NCIt 50 C6891
SNOMED-CT 68 128731008
UMLS 73 C1266114

Summaries for Meningeal Melanomatosis

MalaCards based summary : Meningeal Melanomatosis, also known as leptomeningeal melanomatosis, is related to melanomatosis and diffuse leptomeningeal melanocytosis, and has symptoms including headache, vomiting and neurologic symptoms. An important gene associated with Meningeal Melanomatosis is CWC22 (CWC22 Spliceosome Associated Protein Homolog), and among its related pathways/superpathways are DAG and IP3 signaling and Phospholipase-C Pathway. Affiliated tissues include bone, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Meningeal Melanomatosis

Diseases related to Meningeal Melanomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 melanomatosis 29.4 CDKN2A CWC22 GNA11 GNAQ HRAS NRAS
2 diffuse leptomeningeal melanocytosis 11.2
3 phakomatosis cesioflammea 10.8 GNA11 GNAQ
4 intraocular melanoma 10.8 GNA11 GNAQ
5 giant congenital nevus 10.8 HRAS NRAS
6 benign struma ovarii 10.8 HRAS NRAS
7 schimmelpenning-feuerstein-mims syndrome 10.8 HRAS NRAS
8 ovarian melanoma 10.7 HRAS NRAS
9 marcus gunn phenomenon 10.7 HRAS NRAS
10 syringomyelia 10.7 CWC22 NRAS
11 malignant struma ovarii 10.7 HRAS NRAS
12 mongolian spot 10.6 ENO2 GNAQ
13 myelodysplastic myeloproliferative cancer 10.5 HRAS NRAS
14 conjunctival cancer 10.5 GNA11 GNAQ NRAS
15 mucosal melanoma 10.5 GNA11 GNAQ NRAS
16 conventional fibrosarcoma 10.5 ENO2 NRAS
17 acral lentiginous melanoma 10.5 CDKN2A NRAS
18 nevus, epidermal 10.5 HRAS NRAS
19 malignant ectomesenchymoma 10.5 ENO2 HRAS
20 ectomesenchymoma 10.5 ENO2 HRAS
21 miliary tuberculosis 10.5 ENO2 PDCD1
22 ureter small cell carcinoma 10.5 ENO2 SYP
23 gallbladder adenoma 10.5 CDKN2A HRAS
24 malignant sertoli cell tumor 10.5 ENO2 SYP
25 urinary bladder small cell neuroendocrine carcinoma 10.5 ENO2 SYP
26 auditory system cancer 10.4 ENO2 SYP
27 sinonasal undifferentiated carcinoma 10.4 ENO2 SYP
28 sensory organ benign neoplasm 10.4 ENO2 SYP
29 gallbladder small cell carcinoma 10.4 ENO2 SYP
30 pancreatic somatostatinoma 10.4 ENO2 SYP
31 meningitis 10.4
32 cutaneous ganglioneuroma 10.4 ENO2 SYP
33 extrahepatic bile duct adenocarcinoma 10.4 ENO2 SYP
34 small cell carcinoma of the bladder 10.4 ENO2 SYP
35 papillary tumor of the pineal region 10.4 ENO2 SYP
36 orbital cancer 10.4 ENO2 SYP
37 middle ear adenoma 10.4 ENO2 SYP
38 ovarian carcinosarcoma 10.4 ENO2 SYP
39 pulmonary large cell neuroendocrine carcinoma 10.4 ENO2 SYP
40 subependymal glioma 10.4 ENO2 SYP
41 melanocytic nevus syndrome, congenital 10.4 HRAS NRAS
42 olfactory nerve neoplasm 10.4 ENO2 SYP
43 cauda equina neoplasm 10.4 ENO2 SYP
44 ampulla of vater neoplasm 10.4 HRAS SYP
45 extraosseous chondrosarcoma 10.4 ENO2 SYP
46 benign ependymoma 10.4 ENO2 SYP
47 malignant teratoma 10.4 ENO2 SYP
48 astroblastoma 10.4 ENO2 SYP
49 pineal gland cancer 10.4 ENO2 SYP
50 askin's tumor 10.4 ENO2 NGF

Graphical network of the top 20 diseases related to Meningeal Melanomatosis:



Diseases related to Meningeal Melanomatosis

Symptoms & Phenotypes for Meningeal Melanomatosis

UMLS symptoms related to Meningeal Melanomatosis:


headache, vomiting, neurologic symptoms

MGI Mouse Phenotypes related to Meningeal Melanomatosis:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.21 NGF SYP NRAS HRAS GNAQ ENO2
2 growth/size/body region MP:0005378 10.21 NGF TP53 NRAS HRAS PDCD1 ENO2
3 cardiovascular system MP:0005385 10.2 NGF TP53 NRAS HRAS PDCD1 GNA11
4 homeostasis/metabolism MP:0005376 10.15 PDCD1 NGF NRAS HRAS CDKN2A GNAQ
5 endocrine/exocrine gland MP:0005379 10.13 NRAS TP53 HRAS PDCD1 GNAQ B2M
6 mortality/aging MP:0010768 10.09 HRAS PDCD1 NGF GNAQ NRAS CDKN2A
7 integument MP:0010771 10.08 NGF TP53 NRAS HRAS GNA11 B2M
8 nervous system MP:0003631 10.02 NGF SYP TP53 HRAS PDCD1 ENO2
9 craniofacial MP:0005382 10.01 NRAS HRAS GNAQ ENO2 GNA11 TP53
10 liver/biliary system MP:0005370 9.93 PDCD1 NRAS B2M GNA11 CDKN2A TP53
11 muscle MP:0005369 9.88 PDCD1 NGF CDKN2A GNAQ GNA11 TP53
12 neoplasm MP:0002006 9.85 PDCD1 NRAS HRAS B2M CDKN2A TP53
13 normal MP:0002873 9.8 NGF SYP NRAS HRAS GNAQ GNA11
14 pigmentation MP:0001186 9.55 NRAS GNAQ GNA11 CDKN2A TP53
15 respiratory system MP:0005388 9.5 TP53 HRAS PDCD1 ENO2 GNA11 CDKN2A
16 skeleton MP:0005390 9.17 PDCD1 NRAS HRAS GNAQ GNA11 CDKN2A

Drugs & Therapeutics for Meningeal Melanomatosis

Search Clinical Trials , NIH Clinical Center for Meningeal Melanomatosis

Genetic Tests for Meningeal Melanomatosis

Anatomical Context for Meningeal Melanomatosis

MalaCards organs/tissues related to Meningeal Melanomatosis:

41
Bone

Publications for Meningeal Melanomatosis

Articles related to Meningeal Melanomatosis:

# Title Authors Year
1
Meningeal melanomatosis following discontinuation of dabrafenib: implications for the maintenance of long-term complete remission. ( 28723725 )
2017
2
Meningeal melanomatosis: a challenge for timely diagnosis. ( 25648721 )
2015
3
F-18 fluorodeoxyglucose PET/CT and post hoc PET/MRI in a case of primary meningeal melanomatosis. ( 23483049 )
2013
4
A patient with meningeal melanomatosis treated for periodontal disease with a bone regeneration procedure and dental implants: clinical and behavioral management to support medical compliance. ( 24772265 )
2013
5
Primary malignant meningeal melanomatosis: a clinical, radiological and pathologic case study. ( 22141290 )
2011
6
Primary diffuse meningeal melanomatosis. ( 20220448 )
2010
7
Primary diffuse meningeal melanomatosis: radiologic-pathologic correlation. ( 12533338 )
2003
8
MR imaging of experimental meningeal melanomatosis in nude rats. ( 1460485 )
1992
9
Experimental meningeal melanomatosis. ( 2749474 )
1989
10
Primary meningeal melanomatosis: limitations of current diagnostic techniques. ( 6619899 )
1983

Variations for Meningeal Melanomatosis

Expression for Meningeal Melanomatosis

Search GEO for disease gene expression data for Meningeal Melanomatosis.

Pathways for Meningeal Melanomatosis

Pathways related to Meningeal Melanomatosis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.96 GNA11 GNAQ HRAS NGF NRAS
2
Show member pathways
12.92 GNA11 HRAS NGF NRAS TP53
3
Show member pathways
12.86 GNA11 GNAQ HRAS NRAS TP53
4
Show member pathways
12.86 CDKN2A GNA11 GNAQ HRAS NRAS
5
Show member pathways
12.79 HRAS NGF NRAS TP53
6
Show member pathways
12.75 GNA11 GNAQ HRAS NGF NRAS TP53
7
Show member pathways
12.71 GNA11 HRAS NGF NRAS
8
Show member pathways
12.67 CDKN2A HRAS NRAS TP53
9 12.66 HRAS NGF NRAS TP53
10
Show member pathways
12.66 CDKN2A HRAS NRAS TP53
11
Show member pathways
12.66 CDKN2A HRAS NGF NRAS TP53
12
Show member pathways
12.62 GNAQ HRAS NGF NRAS
13
Show member pathways
12.61 GNA11 GNAQ HRAS NRAS
14
Show member pathways
12.6 HRAS NGF NRAS TP53
15
Show member pathways
12.52 GNA11 GNAQ HRAS NGF NRAS
16 12.45 CDKN2A GNA11 GNAQ HRAS NRAS TP53
17 12.41 ENO2 GNA11 GNAQ NGF SYP
18 12.38 CDKN2A HRAS NRAS TP53
19 12.3 CDKN2A HRAS NRAS TP53
20 12.15 CDKN2A HRAS NRAS TP53
21
Show member pathways
12.11 HRAS NRAS TP53
22
Show member pathways
12.1 GNAQ HRAS NRAS
23
Show member pathways
12.09 HRAS NRAS TP53
24
Show member pathways
12.04 HRAS NRAS TP53
25 12.03 CDKN2A HRAS NRAS TP53
26 11.98 GNAQ HRAS NRAS
27
Show member pathways
11.98 HRAS NGF NRAS TP53
28 11.96 HRAS NRAS TP53
29
Show member pathways
11.92 GNA11 GNAQ HRAS
30
Show member pathways
11.91 GNA11 GNAQ HRAS
31 11.88 HRAS NRAS TP53
32 11.87 GNAQ HRAS NRAS
33 11.86 GNAQ HRAS NRAS
34 11.83 GNAQ HRAS NRAS TP53
35 11.82 CDKN2A HRAS TP53
36 11.79 CDKN2A HRAS NRAS TP53
37 11.75 CDKN2A HRAS NRAS TP53
38 11.57 HRAS NRAS TP53
39 11.57 GNA11 GNAQ HRAS NRAS
40 11.56 GNA11 GNAQ HRAS
41 11.56 HRAS NRAS TP53
42 11.32 CDKN2A HRAS NRAS TP53
43
Show member pathways
11.13 HRAS NRAS
44 11.06 HRAS NRAS
45 11.03 HRAS NRAS
46 11.03 CDKN2A TP53
47
Show member pathways
11.03 CDKN2A TP53
48 11.03 GNA11 GNAQ HRAS NRAS
49
Show member pathways
10.86 GNA11 GNAQ
50 10.85 GNAQ HRAS NRAS

GO Terms for Meningeal Melanomatosis

Biological processes related to Meningeal Melanomatosis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.83 CDKN2A HRAS NGF TP53
2 positive regulation of gene expression GO:0010628 9.78 CDKN2A HRAS NGF TP53
3 positive regulation of apoptotic process GO:0043065 9.71 CDKN2A NGF PDCD1 TP53
4 cell cycle arrest GO:0007050 9.69 CDKN2A HRAS TP53
5 cellular senescence GO:0090398 9.56 CDKN2A HRAS
6 regulation of long-term neuronal synaptic plasticity GO:0048169 9.55 HRAS SYP
7 positive regulation of Ras protein signal transduction GO:0046579 9.54 HRAS NGF
8 action potential GO:0001508 9.49 GNA11 GNAQ
9 G-protein coupled acetylcholine receptor signaling pathway GO:0007213 9.46 GNA11 GNAQ
10 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.43 GNA11 GNAQ
11 replicative senescence GO:0090399 9.37 CDKN2A TP53
12 developmental pigmentation GO:0048066 9.32 GNA11 GNAQ
13 phototransduction, visible light GO:0007603 9.26 GNA11 GNAQ
14 entrainment of circadian clock GO:0009649 9.16 GNA11 GNAQ
15 regulation of melanocyte differentiation GO:0045634 8.96 GNA11 GNAQ
16 Ras protein signal transduction GO:0007265 8.92 CDKN2A HRAS NRAS TP53

Molecular functions related to Meningeal Melanomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTP binding GO:0005525 9.46 GNA11 GNAQ HRAS NRAS
2 G-protein beta/gamma-subunit complex binding GO:0031683 9.32 GNA11 GNAQ
3 guanyl nucleotide binding GO:0019001 9.26 GNA11 GNAQ
4 GTPase activity GO:0003924 9.26 GNA11 GNAQ HRAS NRAS
5 type 2A serotonin receptor binding GO:0031826 8.62 GNA11 GNAQ

Sources for Meningeal Melanomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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