MCID: MNN008
MIFTS: 32

Meningeal Melanomatosis

Categories: Cancer diseases, Neuronal diseases, Skin diseases

Aliases & Classifications for Meningeal Melanomatosis

MalaCards integrated aliases for Meningeal Melanomatosis:

Name: Meningeal Melanomatosis 12 15 71
Leptomeningeal Melanomatosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8243
NCIt 50 C6891
SNOMED-CT 67 128731008
UMLS 71 C1266114

Summaries for Meningeal Melanomatosis

MalaCards based summary : Meningeal Melanomatosis, also known as leptomeningeal melanomatosis, is related to melanomatosis and meningeal melanoma, and has symptoms including vomiting, headache and neurologic symptoms. An important gene associated with Meningeal Melanomatosis is MLANA (Melan-A), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and IL-2 Pathway. Affiliated tissues include bone marrow and spinal cord, and related phenotypes are craniofacial and integument

Related Diseases for Meningeal Melanomatosis

Diseases related to Meningeal Melanomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 melanomatosis 30.8 NRAS MLANA GNAQ
2 meningeal melanoma 29.5 NRAS MLANA GNAQ GNA11
3 melanoma 29.1 NRAS MLANA HRAS GNAQ GNA11
4 skin melanoma 28.9 NRAS MLANA HRAS GNAQ GNA11
5 diffuse leptomeningeal melanocytosis 11.3
6 melanosis, neurocutaneous 10.4
7 hydrocephalus 10.3
8 meningitis 10.2
9 headache 10.2
10 ovarian melanoma 10.1 NRAS MLANA
11 sensory organ benign neoplasm 10.1 NRAS MLANA
12 nasal cavity adenocarcinoma 10.0 MLANA HRAS
13 acneiform dermatitis 10.0 NRAS HRAS
14 nasal cavity cancer 10.0 MLANA HRAS
15 core binding factor acute myeloid leukemia 10.0 NRAS HRAS
16 arachnoid cysts, intracranial 10.0
17 aspiration pneumonia 10.0
18 amnestic disorder 10.0
19 multiple cranial nerve palsy 10.0
20 communicating hydrocephalus 10.0
21 status epilepticus 10.0
22 paraplegia 10.0
23 subacute delirium 10.0
24 intracranial hypertension 10.0
25 new-onset refractory status epilepticus 10.0
26 tuberculous meningitis 10.0
27 dysphagia 10.0
28 oculoectodermal syndrome 10.0 NRAS HRAS
29 large intestine adenocarcinoma 10.0 NRAS HRAS
30 hair whorl 10.0
31 sarcoidosis 1 10.0
32 periodontitis, chronic 10.0
33 viral meningitis 10.0
34 neurosarcoidosis 10.0
35 obstructive hydrocephalus 10.0
36 papilledema 10.0
37 cranial nerve palsy 10.0
38 intracranial hypotension 10.0
39 acute disseminated encephalomyelitis 10.0
40 viral encephalitis 10.0
41 periodontitis 10.0
42 hypertensive encephalopathy 10.0
43 encephalopathy 10.0
44 melanocytic nevus syndrome, congenital 10.0 NRAS HRAS
45 respiratory system benign neoplasm 10.0 MLANA HRAS
46 benign struma ovarii 10.0 NRAS HRAS
47 epithelioid cell melanoma 10.0 MLANA GNA11
48 vulvar disease 10.0 NRAS HRAS
49 acral lentiginous melanoma 10.0 NRAS HRAS
50 myelodysplastic/myeloproliferative neoplasm 10.0 NRAS HRAS

Graphical network of the top 20 diseases related to Meningeal Melanomatosis:



Diseases related to Meningeal Melanomatosis

Symptoms & Phenotypes for Meningeal Melanomatosis

UMLS symptoms related to Meningeal Melanomatosis:


vomiting, headache, neurologic symptoms

MGI Mouse Phenotypes related to Meningeal Melanomatosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.46 GNA11 GNAQ HRAS NRAS
2 integument MP:0010771 9.35 GNA11 GNAQ HRAS MLANA NRAS
3 pigmentation MP:0001186 8.92 GNA11 GNAQ MLANA NRAS

Drugs & Therapeutics for Meningeal Melanomatosis

Search Clinical Trials , NIH Clinical Center for Meningeal Melanomatosis

Genetic Tests for Meningeal Melanomatosis

Anatomical Context for Meningeal Melanomatosis

MalaCards organs/tissues related to Meningeal Melanomatosis:

40
Bone Marrow, Spinal Cord

Publications for Meningeal Melanomatosis

Articles related to Meningeal Melanomatosis:

(show top 50) (show all 66)
# Title Authors PMID Year
1
Primary leptomeningeal melanomatosis manifesting as new-onset refractory status epilepticus a case report - Where do you get the best cerebrospinal fluid sample? 61
33578258 2021
2
Diagnosis of meningeal melanomatosis in a dog using magnetic resonance imaging and cerebrospinal fluid findings. 61
33250483 2021
3
Letter to the Editor Regarding "Brain Atrophy Associated with Primary Diffuse Meningeal Melanomatosis". 61
33348519 2021
4
Primary leptomeningeal melanomatosis successfully treated with PD-1 inhibitor pembrolizumab: A case report. 61
33327228 2020
5
An Uncommon Case of Primary Leptomeningeal Melanoma in a 66-Year-Old White Caucasian Male. 61
33163297 2020
6
[A case of meningeal melanomatosis diagnosed by immunostaining of cerebrospinal fluid]. 61
32641630 2020
7
Brain Atrophy Associated with Primary Diffuse Meningeal Melanomatosis. 61
32004738 2020
8
Pediatric primary diffuse leptomeningeal melanomatosis: Case report and review of the literature. 61
32080099 2020
9
Primary diffuse meningeal melanomatosis - a rare form of meningeal melanoma: case report. 61
31690266 2019
10
Treating TB human neuroectodermal cell line with retinoic acid induces the appearance of neuron-like voltage-gated ionic currents. 61
30660613 2019
11
Primary Diffuse Leptomeningeal Melanomatosis: Case Report and Review of the Literature. 61
30496931 2019
12
Primary Diffuse Leptomeningeal Melanomatosis of Spine: 18F-FDG PET Findings. 61
30516687 2019
13
NRASQ61K mutated diffuse leptomeningeal melanomatosis in an adult patient with a brief review of the so-called "forme fruste" of neurocutaneous melanosis. 61
30145692 2018
14
Primary diffuse leptomeningeal melanomatosis: Description and recommendations. 61
29422361 2018
15
Two cases of primary leptomeningeal melanomatosis mimicking subacute meningitis. 61
28627959 2018
16
Diagnostic Difficulties in Primary Pauci-Melanotic Leptomeningeal Melanomatosis. 61
30231251 2018
17
Primary central nervous system malignant melanoma with leptomeningeal melanomatosis: a case report and review of the literature. 61
28986666 2018
18
[A case of leptomeningeal melanomatosis with acute paraplegia and multiple cranial nerve palsies]. 61
29187689 2017
19
Meningeal melanomatosis following discontinuation of dabrafenib: implications for the maintenance of long-term complete remission. 61
28723725 2017
20
CSF cytology diagnosis of NRAS-mutated primary leptomeningeal melanomatosis with neurocutaneous melanosis. 61
27696542 2017
21
[Melanocytoma and meningeal melanocytosis, similar but different lesions]. 61
28126183 2017
22
Brain 18F-choline PET/CT in primary diffuse leptomeningeal melanomatosis. 61
27085711 2016
23
Primary Amelanotic Leptomeningeal Melanomatosis in a Child: A Rare but Severe Disease. 61
27319310 2016
24
NRAS(Q61K) mutated primary leptomeningeal melanoma in a child: case presentation and discussion on clinical and diagnostic implications. 61
27439913 2016
25
Primary Intracranial Leptomeningeal Melanomatosis. 61
26819692 2015
26
Leptomeningeal melanomatosis associated with neurocutaneous melanosis: an autopsy case report. 61
25521302 2015
27
Meningeal melanomatosis: a challenge for timely diagnosis. 61
25648721 2015
28
Rare and challenging extra-axial brain lesions: CT and MRI findings with clinico-radiological differential diagnosis and pathological correlation. 61
25010368 2014
29
Primary melanocytic tumors of the central nervous system: Report of two cases and review of literature. 61
25371847 2014
30
[A case of leptomeningeal melanomatosis presenting with right abducens nerve palsy]. 61
25142543 2014
31
Vemurafenib for leptomeningeal melanomatosis. 61
23460716 2013
32
F-18 fluorodeoxyglucose PET/CT and post hoc PET/MRI in a case of primary meningeal melanomatosis. 61
23483049 2013
33
A patient with meningeal melanomatosis treated for periodontal disease with a bone regeneration procedure and dental implants: clinical and behavioral management to support medical compliance. 61
24772265 2013
34
[Primary amelanotic meningeal melanomatosis]. 61
22450762 2012
35
Leptomeningeal melanomatosis: stabilization of disease due to radiation, temozolomide and intrathecal liposomal cytarabine. 61
21736503 2011
36
Primary malignant meningeal melanomatosis: a clinical, radiological and pathologic case study. 61
22141290 2011
37
Primary melanocytic tumors of the central nervous system: a neuroradiological and clinicopathological study of five cases and brief review of literature. 61
21743173 2011
38
Neurological picture. Ascending paralysis from malignant leptomeningeal melanomatosis. 61
20360167 2010
39
Primary diffuse meningeal melanomatosis. 61
20220448 2010
40
Pigmented lesions of the central nervous system: radiologic-pathologic correlation. 61
19755608 2009
41
[Cerebellopontine angle meningeal melanocytoma: a benign tumor?]. 61
19688139 2009
42
Disseminated melanoma in a dog with involvement of leptomeninges and bone marrow. 61
19112120 2009
43
Prognostic factors and outcomes in patients with leptomeningeal melanomatosis. 61
18708343 2008
44
Case 134: primary leptomeningeal melanomatosis. 61
18487543 2008
45
[Primary diffuse meningeal melanomatosis. Case report]. 61
17330185 2007
46
Cognitive decline in an elderly hospitalized patient with primary leptomeningeal melanomatosis. 61
15586607 2004
47
Extensive metastatic leptomeningeal melanomatosis as the first clinical sign of a cutaneous melanoma: morphological correlations between magnetic resonance imaging and autopsy findings. A case report. 61
12827619 2003
48
Neurocutaneous melanomatosis with a rapidly deteriorating course. 61
12591651 2003
49
Primary diffuse meningeal melanomatosis: radiologic-pathologic correlation. 61
12533338 2003
50
Primary leptomeningeal melanoma. 61
12486366 2002

Variations for Meningeal Melanomatosis

Expression for Meningeal Melanomatosis

Search GEO for disease gene expression data for Meningeal Melanomatosis.

Pathways for Meningeal Melanomatosis

Pathways related to Meningeal Melanomatosis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 NRAS HRAS GNAQ GNA11
2
Show member pathways
12.98 NRAS HRAS GNAQ GNA11
3
Show member pathways
12.86 NRAS HRAS GNAQ GNA11
4
Show member pathways
12.84 NRAS HRAS GNAQ GNA11
5
Show member pathways
12.82 NRAS HRAS GNAQ GNA11
6
Show member pathways
12.72 NRAS HRAS GNAQ GNA11
7
Show member pathways
12.68 NRAS HRAS GNAQ GNA11
8
Show member pathways
12.66 NRAS HRAS GNAQ GNA11
9 12.61 NRAS HRAS GNAQ GNA11
10
Show member pathways
12.59 NRAS HRAS GNA11
11
Show member pathways
12.54 NRAS HRAS GNAQ GNA11
12
Show member pathways
12.53 NRAS HRAS GNAQ
13
Show member pathways
12.5 NRAS HRAS GNAQ GNA11
14
Show member pathways
12.47 NRAS HRAS GNA11
15
Show member pathways
12.39 HRAS GNAQ GNA11
16
Show member pathways
12.39 NRAS HRAS GNAQ GNA11
17
Show member pathways
12.34 NRAS HRAS GNAQ GNA11
18
Show member pathways
12.13 HRAS GNAQ GNA11
19
Show member pathways
12.13 NRAS HRAS GNAQ GNA11
20 11.9 NRAS HRAS GNAQ
21
Show member pathways
11.85 HRAS GNAQ GNA11
22
Show member pathways
11.83 HRAS GNAQ GNA11
23 11.81 NRAS HRAS GNAQ
24 11.78 NRAS HRAS GNAQ
25 11.77 NRAS HRAS GNAQ
26
Show member pathways
11.73 NRAS HRAS GNAQ GNA11
27
Show member pathways
11.72 NRAS HRAS GNAQ
28 11.58 NRAS HRAS
29 11.57 NRAS HRAS
30 11.56 NRAS HRAS
31 11.54 NRAS HRAS
32 11.54 HRAS GNAQ
33
Show member pathways
11.52 NRAS HRAS
34 11.46 NRAS HRAS
35 11.42 NRAS HRAS GNAQ GNA11
36 11.4 GNAQ GNA11
37 11.4 NRAS HRAS GNAQ GNA11
38 11.39 HRAS GNAQ GNA11
39 11.37 NRAS HRAS
40 11.32 NRAS HRAS
41 11.27 GNAQ GNA11
42 11.26 NRAS HRAS
43 11.22 GNAQ GNA11
44 11.2 GNAQ GNA11
45 11.19 NRAS HRAS
46 11.14 NRAS HRAS
47 11.14 NRAS HRAS
48
Show member pathways
11.12 NRAS HRAS
49
Show member pathways
11.07 NRAS HRAS
50 11.06 NRAS HRAS GNAQ GNA11

GO Terms for Meningeal Melanomatosis

Cellular components related to Meningeal Melanomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi apparatus GO:0005794 9.26 NRAS MLANA HRAS GNAQ
2 photoreceptor outer segment GO:0001750 9.16 GNAQ GNA11
3 heterotrimeric G-protein complex GO:0005834 8.62 GNAQ GNA11

Biological processes related to Meningeal Melanomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras protein signal transduction GO:0007265 9.37 NRAS HRAS
2 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.32 GNAQ GNA11
3 action potential GO:0001508 9.26 GNAQ GNA11
4 G protein-coupled acetylcholine receptor signaling pathway GO:0007213 9.16 GNAQ GNA11
5 phototransduction, visible light GO:0007603 8.96 GNAQ GNA11
6 entrainment of circadian clock GO:0009649 8.62 GNAQ GNA11

Molecular functions related to Meningeal Melanomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTP binding GO:0005525 9.46 NRAS HRAS GNAQ GNA11
2 GDP binding GO:0019003 9.4 NRAS HRAS
3 G protein-coupled receptor binding GO:0001664 9.37 GNAQ GNA11
4 G-protein beta/gamma-subunit complex binding GO:0031683 9.32 GNAQ GNA11
5 guanyl nucleotide binding GO:0019001 9.26 GNAQ GNA11
6 type 2A serotonin receptor binding GO:0031826 8.96 GNAQ GNA11
7 GTPase activity GO:0003924 8.92 NRAS HRAS GNAQ GNA11

Sources for Meningeal Melanomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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