MCID: MNN006
MIFTS: 26

Meninges Hemangiopericytoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Meninges Hemangiopericytoma

MalaCards integrated aliases for Meninges Hemangiopericytoma:

Name: Meninges Hemangiopericytoma 12 15
Hemangiopericytoma of Meninges 12 71
Meningeal Hemangiopericytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4957
NCIt 49 C4660
UMLS 71 C0349622

Summaries for Meninges Hemangiopericytoma

MalaCards based summary : Meninges Hemangiopericytoma, also known as hemangiopericytoma of meninges, is related to fibrous meningioma and hemangiopericytoma, malignant. An important gene associated with Meninges Hemangiopericytoma is NAB2 (NGFI-A Binding Protein 2), and among its related pathways/superpathways are Development IGF-1 receptor signaling and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Donepezil and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and t cells.

Related Diseases for Meninges Hemangiopericytoma

Diseases related to Meninges Hemangiopericytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 fibrous meningioma 30.1 UBE2D1 NAB2 CD34
2 hemangiopericytoma, malignant 29.5 UBE2D1 STAT6 NAB2 IGF2 CD99 CD34
3 insulin-like growth factor i 29.1 IGFBP3 IGF2
4 meningioma, familial 28.9 UBE2D1 STAT6 NAB2 IGF2 EPB41L3 CD34
5 meningioma, radiation-induced 10.7
6 spinal meningioma 10.7
7 secretory meningioma 10.7
8 lymphoplasmacyte-rich meningioma 10.7
9 hypoglycemia 10.3
10 rare tumor 10.3
11 mesenchymal cell neoplasm 10.2
12 sarcomatous intrahepatic cholangiocarcinoma 10.2 STAT6 CD34
13 glomangiomatosis 10.2 STAT6 CD34
14 nasal cavity neoplasm 10.1 UBE2D1 CD34
15 parasagittal meningioma 10.1 UBE2D1 CD34
16 spindle cell liposarcoma 10.1 UBE2D1 CD34
17 angiomatous meningioma 10.1 UBE2D1 CD34
18 cerebral convexity meningioma 10.1 UBE2D1 CD34
19 spindle cell thymoma 10.1 UBE2D1 CD34
20 pseudosarcomatous fibromatosis 10.1 NAB2 CD34
21 pleomorphic lipoma 10.1 UBE2D1 CD34
22 chondrosarcoma 10.1
23 mesenchymal chondrosarcoma 10.1
24 benign meningioma 10.1
25 orbital cancer 10.1 UBE2D1 CD34
26 kidney hemangiopericytoma 10.1 IGF2 CD34
27 extraskeletal mesenchymal chondrosarcoma 10.1 NAB2 CD99
28 benign fibrous mesothelioma 10.1 IGF2 CD34
29 liver fibroma 10.0 UBE2D1 IGF2
30 pulmonary vein leiomyosarcoma 10.0 CD99 CD34
31 fibroma 10.0 CD99 CD34
32 epidural neoplasm 10.0 CD99 CD34
33 testicular fibroma 10.0 CD99 CD34
34 smooth muscle tumor 10.0 IGF2 CD34
35 gliofibroma 9.9 CD99 CD34
36 kaposi sarcoma 9.9
37 retinoblastoma 9.9
38 ocular motor apraxia 9.9
39 3-methylglutaconic aciduria, type iii 9.9
40 ataxia and polyneuropathy, adult-onset 9.9
41 cholangiocarcinoma 9.9
42 hydrops, lactic acidosis, and sideroblastic anemia 9.9
43 connective tissue benign neoplasm 9.9
44 sarcoma 9.9
45 arteriovenous malformation 9.9
46 obstructive jaundice 9.9
47 amenorrhea 9.9
48 hypoglycemic coma 9.9
49 hyperostosis 9.9
50 neurilemmoma 9.9

Graphical network of the top 20 diseases related to Meninges Hemangiopericytoma:



Diseases related to Meninges Hemangiopericytoma

Symptoms & Phenotypes for Meninges Hemangiopericytoma

Drugs & Therapeutics for Meninges Hemangiopericytoma

Drugs for Meninges Hemangiopericytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Donepezil Approved Phase 3 120014-06-4 3152
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
3 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
4 Neurotransmitter Agents Phase 3
5 Nootropic Agents Phase 3
6 Cholinergic Agents Phase 3
7 Cholinesterase Inhibitors Phase 3
8 Analgesics Phase 3
9 Liver Extracts Phase 3
10 Cola Phase 3
11 Narcotics Phase 3
12 Anesthetics Phase 3
13 Anesthetics, General Phase 3
14 Analgesics, Opioid Phase 3
15 Adjuvants, Anesthesia Phase 3
16 Central Nervous System Depressants Phase 3
17 Anesthetics, Intravenous Phase 3
18
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
19
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
20 Alkylating Agents Phase 2
21 Ginkgo Phase 2
22 Protein Kinase Inhibitors Phase 2
23
Verteporfin Approved, Investigational Phase 1 129497-78-5
24
Trioxsalen Approved Phase 1 3902-71-4 5585
25
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
26
Lenalidomide Approved Phase 1 191732-72-6 216326
27
Aldesleukin Approved Phase 1 110942-02-4, 85898-30-2
28
Bortezomib Approved, Investigational Phase 1 179324-69-7 387447 93860
29
Sirolimus Approved, Investigational Phase 1 53123-88-9 5284616 6436030 46835353
30
Everolimus Approved Phase 1 159351-69-6 6442177 70789204
31
Miconazole Approved, Investigational, Vet_approved Phase 1 22916-47-8 4189
32
Carboplatin Approved Phase 1 41575-94-4 10339178 498142 38904
33
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
34
Somatostatin Approved, Investigational Phase 1 51110-01-1, 38916-34-6 53481605
35
Docetaxel Approved, Investigational Phase 1 114977-28-5 148124
36
Parathyroid hormone Approved, Investigational Phase 1 9002-64-6
37
Calcitriol Approved, Nutraceutical Phase 1 32222-06-3 134070 5280453
38
Calcium Approved, Nutraceutical Phase 1 7440-70-2 271
39
Entinostat Investigational Phase 1 209783-80-2
40 Dermatologic Agents Phase 1
41 Photosensitizing Agents Phase 1
42 Dihematoporphyrin Ether Phase 1
43 Hormones Phase 1
44 Angiogenesis Inhibitors Phase 1
45 Immunologic Factors Phase 1
46 Interleukin-2 Phase 1
47 Analgesics, Non-Narcotic Phase 1
48 Anti-Infective Agents Phase 1
49 Anti-Retroviral Agents Phase 1
50 Hormone Antagonists Phase 1

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Phase III Double Blind, Placebo Controlled Study of Donepezil in the Irradiated Brain Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
2 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Phase II Study on ET-743 in Advanced Soft Tissue Sarcomas of the Adult Completed NCT00003939 Phase 2 trabectedin
4 Donepezil and EGb761 in Improving Neurocognitive Function in Patients Who Have Previously Undergone Radiation Therapy for Primary Brain Tumor or Brain Metastases Completed NCT00070161 Phase 2 donepezil hydrochloride
5 ZD1839 FOR Treatment Of Recurrent Or Progressive Malignant Astrocytoma Or Glioblastoma And Recurrent Or Progressive Meningioma: A Phase II Study With A Phase I Component For Patients Receiving EIAEDs Completed NCT00025675 Phase 2 gefitinib
6 Photodynamic Therapy For Childhood Brain Tumors, A Phase I Study Unknown status NCT00002647 Phase 1 verteporfin
7 A Phase I Trial Of A Thalidomide Analog, CC-5013, For The Treatment Of Patients With Recurrent High-Grade Gliomas Completed NCT00036894 Phase 1 lenalidomide
8 Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2 Completed NCT01082926 Phase 1
9 A Phase I Study of Bortezomib and Temozolomide in Patients With Refractory Solid Tumors Completed NCT00544284 Phase 1 bortezomib;temozolomide
10 A Pilot Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors Completed NCT00784914 Phase 1 temsirolimus
11 A Phase I Trial of Subcutaneous And/Or Oral Calcitriol [(1,25-COH)2D3] and Carboplatin in Advanced Solid Tumors Completed NCT00008086 Phase 1 carboplatin
12 A PHASE I STUDY OF THE COMBINATION OF CAI AND PACLITAXEL IN ADULT PATIENTS WITH REFRACTORY CANCERS OR LYMPHOMA Completed NCT00019019 Phase 1 carboxyamidotriazole;paclitaxel
13 A Phase I, Open-Label, Maximum Tolerated Single-Cycle and Four-Cycle Dose-Finding Study to Evaluation the Safety and Tolerability of 90Y-SMT 487 Administered by Intravenous Infusion to Subjects With Refractory Somatostatin-Receptor Positive Tumors Completed NCT00006368 Phase 1
14 Phase I Pharmacokinetic Trial of Thalidomide and Docetaxel: A Regimen Based on Anti-Angiogenic Therapeutic Principles Completed NCT00049296 Phase 1 docetaxel;thalidomide
15 A Phase I Study of an Oral Histone Deacetylase Inhibitor, MS-275, in Refractory Solid Tumors and Lymphomas Completed NCT00020579 Phase 1 entinostat
16 Identification of Genes Involved in the Pathogenesis of Gliomas by Transcriptome Analysis Completed NCT00967200
17 Temozolomide Induced Changes in Semen/Sperm Analysis in Men With Newly Diagnosed, Progressive or Recurrent Primary Malignant Brain Tumors Completed NCT00499798
18 Prospective Study on the Short-Term Adverse Effects From Gamma Knife Radiosurgery Completed NCT00255671
19 Perfusion Magnetic Resonance Imaging of Brain Tumors: Correlation With Indicators of Angiogenesis Withdrawn NCT00005790

Search NIH Clinical Center for Meninges Hemangiopericytoma

Genetic Tests for Meninges Hemangiopericytoma

Anatomical Context for Meninges Hemangiopericytoma

MalaCards organs/tissues related to Meninges Hemangiopericytoma:

40
Brain, Liver, T Cells, Smooth Muscle, Skeletal Muscle, Kidney, B Cells

Publications for Meninges Hemangiopericytoma

Articles related to Meninges Hemangiopericytoma:

# Title Authors PMID Year
1
Hemangiopericytoma of meninges--a "malignant" challenge. 61
24631649 2015
2
Hemangiopericytoma of meninges. I. Histopathological variability and differential diagnosis. 61
3811681 1986
3
Hemangiopericytoma of meninges. II. General and clinical data. 61
3811682 1986

Variations for Meninges Hemangiopericytoma

Expression for Meninges Hemangiopericytoma

Search GEO for disease gene expression data for Meninges Hemangiopericytoma.

Pathways for Meninges Hemangiopericytoma

Pathways related to Meninges Hemangiopericytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.52 STAT6 IGFBP3 IGF2
2 9.95 IGFBP3 IGF2

GO Terms for Meninges Hemangiopericytoma

Biological processes related to Meninges Hemangiopericytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell growth GO:0001558 8.62 IGFBP3 EPB41L3

Sources for Meninges Hemangiopericytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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