Meninges Sarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Meninges Sarcoma

MalaCards integrated aliases for Meninges Sarcoma:

Name: Meninges Sarcoma ¹² ¹⁵

Leptomeningeal Sarcoma ⁷³

Meningothelial Sarcoma ⁷³

Sarcoma of Meninges ¹²

Meningeal Sarcoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7614

NCIt ⁵⁰ C4073

SNOMED-CT ⁶⁸ 277996009 78303004

UMLS ⁷³ C0302327

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Summaries for Meninges Sarcoma

MalaCards based summary : Meninges Sarcoma, also known as leptomeningeal sarcoma, is related to pigmented villonodular synovitis and adenosarcoma. An important gene associated with Meninges Sarcoma is CSF1R (Colony Stimulating Factor 1 Receptor), and among its related pathways/superpathways are MAPK signaling pathway and PI3K-Akt signaling pathway. Related phenotypes are craniofacial and limbs/digits/tail

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Related Diseases for Meninges Sarcoma

Diseases related to Meninges Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)

#	Related Disease	Score	Top Affiliating Genes
1	pigmented villonodular synovitis	10.4	CSF1R TP53
2	adenosarcoma	10.4	MB TP53
3	pleuropulmonary blastoma	10.4	MB TP53
4	mixed cell type cancer	10.4	MB TP53
5	myxosarcoma	10.4	MB TP53
6	medullomyoblastoma	10.3	MB TP53
7	malignant mesenchymoma	10.3	MB TP53
8	cerebral neuroblastoma	10.3	IGF2 TP53
9	papilloma of choroid plexus	10.3	IGF2 TP53
10	embryonal rhabdomyosarcoma	10.2	IGF2 MB
11	skeletal muscle cancer	10.2	IGF2 MB
12	histiocytoma	10.2	MB TP53
13	atypical teratoid rhabdoid tumor	10.1	IGF2 TP53
14	endocrine pancreas disease	10.1	GCG IGF2
15	pancreas disease	10.1	GCG IGF2
16	angiomyoma	10.0	CD34 MB
17	cellular neurofibroma	10.0	CD34 TP53
18	intestinal disease	10.0	GCG TP53
19	spindle cell synovial sarcoma	9.9	CD34 MB
20	breast benign neoplasm	9.9	CD34 TP53
21	cardiovascular organ benign neoplasm	9.9	CD34 MB
22	thoracic benign neoplasm	9.9	CD34 TP53
23	benign perivascular tumor	9.9	CD34 MB
24	liver angiosarcoma	9.9	CD34 TP53
25	gastric leiomyosarcoma	9.9	CD34 IGF2
26	glomangioma	9.9	CD34 MB
27	gastroesophageal reflux	9.9	GCG TP53
28	sarcoma	9.9
29	meningitis	9.9
30	clear cell ependymoma	9.8	CD34 TP53
31	leiomyosarcoma	9.8	IGF2 MB TP53
32	cellular schwannoma	9.8	CD34 TP53
33	rhabdomyosarcoma	9.8	IGF2 MB TP53
34	organ system benign neoplasm	9.8	CD34 TP53
35	endocrine gland cancer	9.8	GCG TP53
36	gliosarcoma	9.8
37	deep angioma	9.8	CD34 CREB3L2
38	conventional fibrosarcoma	9.8	CD34 CREB3L2
39	intramuscular hemangioma	9.7	CD34 CREB3L2
40	synovium cancer	9.7	CD34 CREB3L2
41	spindle cell liposarcoma	9.7	CD34 CREB3L2
42	peripheral nervous system neoplasm	9.7	CD34 TP53
43	infiltrating lipoma	9.7	CD34 CREB3L2
44	pleomorphic lipoma	9.7	CD34 CREB3L2
45	cell type benign neoplasm	9.7	CD34 TP53
46	skin sarcoma	9.7	CD34 CREB3L2
47	dermatofibrosarcoma protuberans	9.6	CD34 TP53
48	nervous system cancer	9.6	CD34 TP53
49	endometrial stromal sarcoma	9.6	MB TP53
50	sarcomatoid squamous cell skin carcinoma	9.5	CD34 MB TP53

Graphical network of the top 20 diseases related to Meninges Sarcoma:

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Symptoms & Phenotypes for Meninges Sarcoma

MGI Mouse Phenotypes related to Meninges Sarcoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial	MP:0005382	9.26	CREB3L2 CSF1R IGF2 TP53
2	limbs/digits/tail	MP:0005371	8.92	CREB3L2 CSF1R IGF2 TP53

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Drugs & Therapeutics for Meninges Sarcoma

Search Clinical Trials , NIH Clinical Center for Meninges Sarcoma

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Genetic Tests for Meninges Sarcoma

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Anatomical Context for Meninges Sarcoma

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Publications for Meninges Sarcoma

Articles related to Meninges Sarcoma:

#	Title	Authors	Year
1	Long-term survival in gliosarcoma with radiation-induced meningeal sarcomas: Case report and molecular features. ( 26458625 )	Wang Z....Zhu X.X.	2015
2	Primary C1-2, intradural, extramedullary meningeal sarcoma with glial fibrillary acidic protein-immunoreactive components: a spinal gliosarcoma? Case report and review of the literature. ( 12450287 )	Barbagallo G.M....Albanese V.	2002
3	Meningeal sarcoma with rhabdomyoblastic differentiation: case report. ( 1584397 )	Ferracini R....Pileri S.	1992

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Genes for Meninges Sarcoma

Genes related to Meninges Sarcoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CSF1R	Colony Stimulating Factor 1 Receptor	Protein Coding	14.51	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	MB	Myoglobin	Protein Coding	14.33	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	TP53	Tumor Protein P53	Protein Coding	14	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	IGF2	Insulin Like Growth Factor 2	Protein Coding	13.85	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	CREB3L2	CAMP Responsive Element Binding Protein 3 Like 2	Protein Coding	5.38	DISEASES inferred ¹⁵
6	CD34	CD34 Molecule	Protein Coding	3.18	DISEASES inferred ¹⁵
7	GCG	Glucagon	Protein Coding	3.18	DISEASES inferred ¹⁵

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Variations for Meninges Sarcoma

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Expression for Meninges Sarcoma

Search GEO for disease gene expression data for Meninges Sarcoma.

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Pathways for Meninges Sarcoma

Pathways related to Meninges Sarcoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	MAPK signaling pathway ¹ ³⁷	12.17	CSF1R IGF2 TP53
2	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	11.75	CREB3L2 CSF1R IGF2 TP53
3	AKT Signaling Pathway ⁶⁷	11.29	CREB3L2 CSF1R TP53
4	C-MYB transcription factor network ¹	11.15	CD34 CSF1R
5	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.02	CD34 CSF1R

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GO Terms for Meninges Sarcoma

Biological processes related to Meninges Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	multicellular organism development	GO:0007275	9.56	CREB3L2 CSF1R IGF2 TP53
2	hemopoiesis	GO:0030097	9.32	CD34 CSF1R
3	negative regulation of apoptotic process	GO:0043066	9.26	CSF1R GCG IGF2 TP53
4	positive regulation of protein serine/threonine kinase activity	GO:0071902	9.16	CSF1R IGF2
5	cell proliferation	GO:0008283	8.92	CD34 CSF1R GCG TP53

Molecular functions related to Meninges Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein phosphatase binding	GO:0019903	8.62	CSF1R TP53

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Sources for Meninges Sarcoma

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⁷⁴ UMLS via Orphanet

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⁷⁶ Wikipedia