Meningioma, Radiation-Induced disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MNN042 MIFTS: 36	Meningioma, Radiation-Induced Categories: Rare diseases, Neuronal diseases, Endocrine diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Download Expand all tables

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Aliases & Classifications for Meningioma, Radiation-Induced

MalaCards integrated aliases for Meningioma, Radiation-Induced:

Name: Meningioma, Radiation-Induced ⁵⁷ ¹³

Radiation Induced Meningioma ⁵³ ⁷³

Meningioma ⁵⁹ ⁷³

Mnri ⁵⁷ ⁵³

Meningioma, Benign, No Icd-O Subtype ⁷³

Characteristics:

Orphanet epidemiological data:

⁵⁹

meningioma
Prevalence: 1-9/100000 (United States),1-9/1000000 (Europe),1-9/100000 (Europe); Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Endocrine diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Neoplasms

Benign neoplasms

Benign neoplasm of meninges

Benign neoplasm: Meninges, unspecified

Orphanet: ⁵⁹

Rare neurological diseases

Rare endocrine diseases

External Ids:

OMIM ⁵⁷ 606190

Orphanet ⁵⁹ ORPHA2495

MESH via Orphanet ⁴⁵ D008579

UMLS via Orphanet ⁷⁴ C0025286

ICD10 via Orphanet ³⁴ D32.9

MedGen ⁴² C1853554

UMLS ⁷³ C1853554 C1762616

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Summaries for Meningioma, Radiation-Induced

MalaCards based summary : Meningioma, Radiation-Induced, also known as radiation induced meningioma, is related to meningioma, familial and spinal meningioma. An important gene associated with Meningioma, Radiation-Induced is PDGFB (Platelet Derived Growth Factor Subunit B), and among its related pathways/superpathways is Glioblastoma Multiforme. Affiliated tissues include pituitary, testes and brain, and related phenotypes are obesity and hydrocephalus

Description from OMIM: 606190

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Related Diseases for Meningioma, Radiation-Induced

Diseases related to Meningioma, Radiation-Induced via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 469)

#	Related Disease	Score	Top Affiliating Genes
1	meningioma, familial	32.5	NF2 PDGFB
2	spinal meningioma	12.3
3	optic nerve sheath meningioma	12.2
4	intraorbital meningioma	12.1
5	rhabdoid meningioma	12.0
6	lung meningioma	12.0
7	benign meningioma	12.0
8	secretory meningioma	12.0
9	lymphoplasmacyte-rich meningioma	11.9
10	cerebral meningioma	11.9
11	chordoid meningioma	11.9
12	fibrous meningioma	11.9
13	transitional meningioma	11.9
14	tuberculum sellae meningioma	11.9
15	skull base meningioma	11.9
16	olfactory groove meningioma	11.9
17	cerebellopontine angle meningioma	11.9
18	foramen magnum meningioma	11.9
19	cavernous sinus meningioma	11.9
20	meningothelial meningioma	11.9
21	clear cell meningioma	11.9
22	brain meningioma	11.9
23	pineal region meningioma	11.9
24	parasagittal meningioma	11.9
25	petrous apex meningioma	11.9
26	intraventricular meningioma	11.9
27	anterior cranial fossa meningioma	11.9
28	clivus meningioma	11.9
29	cerebral falx meningioma	11.9
30	petroclival meningioma	11.9
31	choroid plexus meningioma	11.9
32	middle cranial fossa meningioma	11.9
33	microcystic meningioma	11.9
34	suprasellar meningioma	11.9
35	angiomatous meningioma	11.9
36	jugular foramen meningioma	11.9
37	sphenoorbital meningioma	11.9
38	psammomatous meningioma	11.9
39	parapharyngeal meningioma	11.9
40	diaphragma sellae meningioma	11.9
41	lateral ventricle meningioma	11.9
42	brainstem intraparenchymal clear cell meningioma	11.9
43	anterior foramen magnum meningioma	11.9
44	frontal convexity meningioma	11.9
45	pituitary stalk meningioma	11.9
46	pediatric meningioma	11.8
47	intracerebral cystic meningioma	11.8
48	multiple skull base meningioma	11.8
49	cerebral convexity meningioma	11.8
50	internal auditory canal meningioma	11.7

Graphical network of the top 20 diseases related to Meningioma, Radiation-Induced:

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Symptoms & Phenotypes for Meningioma, Radiation-Induced

Clinical features from OMIM:

606190

Human phenotypes related to Meningioma, Radiation-Induced:

⁵⁹ (show top 50) (show all 74)

#	Description	Orphanet Frequency
1	obesity ⁵⁹	Occasional (29-5%)
2	hydrocephalus ⁵⁹	Occasional (29-5%)
3	emotional lability ⁵⁹	Very rare (<4-1%)
4	seizures ⁵⁹	Frequent (79-30%)
5	ataxia ⁵⁹	Occasional (29-5%)
6	nausea and vomiting ⁵⁹	Frequent (79-30%)
7	neurological speech impairment ⁵⁹	Very rare (<4-1%)
8	facial palsy ⁵⁹	Occasional (29-5%)
9	increased intracranial pressure ⁵⁹	Occasional (29-5%)
10	blindness ⁵⁹	Very rare (<4-1%)
11	cognitive impairment ⁵⁹	Occasional (29-5%)
12	cranial nerve paralysis ⁵⁹	Occasional (29-5%)
13	hypogonadotrophic hypogonadism ⁵⁹	Frequent (79-30%)
14	memory impairment ⁵⁹	Occasional (29-5%)
15	neoplasm of the skin ⁵⁹	Very rare (<4-1%)
16	papilledema ⁵⁹	Occasional (29-5%)
17	difficulty walking ⁵⁹	Occasional (29-5%)
18	back pain ⁵⁹	Very rare (<4-1%)
19	proptosis ⁵⁹	Very rare (<4-1%)
20	slow decrease in visual acuity ⁵⁹	Occasional (29-5%)
21	headache ⁵⁹	Frequent (79-30%)
22	focal seizures ⁵⁹	Frequent (79-30%)
23	tinnitus ⁵⁹	Very rare (<4-1%)
24	abnormality of the sense of smell ⁵⁹	Occasional (29-5%)
25	cerebral hemorrhage ⁵⁹	Very rare (<4-1%)
26	abnormality of the cerebellum ⁵⁹	Occasional (29-5%)
27	urinary incontinence ⁵⁹	Very rare (<4-1%)
28	ophthalmoplegia ⁵⁹	Occasional (29-5%)
29	secondary growth hormone deficiency ⁵⁹	Frequent (79-30%)
30	syncope ⁵⁹	Very rare (<4-1%)
31	impotence ⁵⁹	Frequent (79-30%)
32	decreased circulating cortisol level ⁵⁹	Frequent (79-30%)
33	decreased serum estradiol ⁵⁹	Frequent (79-30%)
34	decreased testosterone in males ⁵⁹	Frequent (79-30%)
35	pituitary hypothyroidism ⁵⁹	Frequent (79-30%)
36	hemiparesis ⁵⁹	Occasional (29-5%)
37	excessive daytime somnolence ⁵⁹	Very rare (<4-1%)
38	functional motor problems ⁵⁹	Occasional (29-5%)
39	lower limb muscle weakness ⁵⁹	Occasional (29-5%)
40	decreased circulating acth level ⁵⁹	Frequent (79-30%)
41	bitemporal hemianopia ⁵⁹	Frequent (79-30%)
42	abnormal kinetic perimetry test ⁵⁹	Occasional (29-5%)
43	oculomotor nerve palsy ⁵⁹	Occasional (29-5%)
44	prolactin excess ⁵⁹	Frequent (79-30%)
45	abnormal brain fdg positron emission tomography ⁵⁹	Frequent (79-30%)
46	neurofibromas ⁵⁹	Occasional (29-5%)
47	chromosomal breakage induced by ionizing radiation ⁵⁹	Very frequent (99-80%)
48	increased sensitivity to ionizing radiation ⁵⁹	Very frequent (99-80%)
49	intracranial meningioma ⁵⁹	Very frequent (99-80%)
50	amenorrhea ⁵⁹	Frequent (79-30%)

GenomeRNAi Phenotypes related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00221-A-2	9.1	PDGFB
2	Decreased viability	GR00221-A-3	9.1	NF2 PDGFB
3	Decreased viability	GR00240-S-1	9.1	PDGFB
4	Decreased viability	GR00402-S-2	9.1	NF2 PDGFB

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Drugs & Therapeutics for Meningioma, Radiation-Induced

Search Clinical Trials , NIH Clinical Center for Meningioma, Radiation-Induced

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Genetic Tests for Meningioma, Radiation-Induced

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Anatomical Context for Meningioma, Radiation-Induced

MalaCards organs/tissues related to Meningioma, Radiation-Induced:

⁴¹

Pituitary, Testes, Brain, Skin, Tongue, Hypothalamus, Cerebellum

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Publications for Meningioma, Radiation-Induced

Articles related to Meningioma, Radiation-Induced:

(show all 31)

#	Title	Authors	Year
1	Radiation-induced meningiomas after BNCT in patients with malignant glioma. ( 26122975 )	Kageji T....Nakagawa Y.	2015
2	Tumor-to-tumor metastasis from pituitary carcinoma to radiation-induced meningioma. ( 22989053 )	Zhou Q....Cui L.	2013
3	A radiation-induced meningioma &quot;cures&quot; a complex dural arteriovenous fistula. ( 23765916 )	Copeland W.R....Link M.J.	2013
4	Metastatic olfactory neuroblastoma invading a radiation-induced meningioma. ( 21752653 )	Dimou J....Kaye A.H.	2011
5	[Exacerbation of radiation induced meningioma due to hemorrhage after cerebral angiography: a case report]. ( 21270478 )	Yamaguchi S....Iwaki T.	2011
6	Radiation-induced meningiomas: a shadow in the success story of childhood leukemia. ( 19179425 )	Banerjee J....Harila-Saari A.	2009
7	Radiation-induced meningioma concealed by shunt valve artifact: case report. ( 18424999 )	Singleton R.H....Lunsford L.D.	2008
8	Radiation-induced meningiomas: clinical, cytogenetic, and microarray features. ( 18604545 )	Lillehei K.O....Kleinschmidt-DeMasters B.K.	2008
9	Radiation-induced meningioma. ( 18447746 )	Umansky F....Spektor S.	2008
10	Radiation-induced meningioma following prophylactic radiotherapy for acute lymphoblastic leukemia in childhood. ( 17190987 )	Kawahara I....Hayashi T.	2007
11	Radiation induced meningioma with a short latent period following high dose cranial irradiation - case report and literature review. ( 16292489 )	Choudhary A....Kumar M.	2006
12	High-dose radiation-induced meningioma in children - case report and critical review of the literature. ( 15744628 )	Caroli E....Ferrante L.	2005
13	High dose radiation induced meningioma. ( 15799195 )	Shenoy S.N....Raja A.	2004
14	Radiation-induced meningiomas: clinical, pathological, cytokinetic, and cytogenetic characteristics. ( 15200115 )	Al-Mefty O....Harrison M.J.	2004
15	Radiation-induced meningioma: a descriptive study of 253 cases. ( 12450029 )	Sadetzki S....Nass D.	2002
16	Radiation-induced meningioma with a long latency period: a case report. ( 11511997 )	BoljesA-kovA! E....BA-zik I.	2001
17	Radiation-induced meningioma: a distinct molecular genetic pattern? ( 10901233 )	Shoshan Y....Cowell J.K.	2000
18	Radiation-induced meningioma evaluated with positron emission tomography with fludeoxyglucose F 18. ( 8733970 )	Kado H....Uemura K.	1996
19	Advanced nasopharyngeal carcinoma and radiation-induced meningioma in dizygotic twins--a rare case report. ( 8938229 )	Stein M.E....Kuten A.	1996
20	Radiation-induced meningioma in children: report of two cases and review of the literature. ( 8753667 )	Starshak R.J.	1996
21	Radiation-induced meningioma following radiation therapy for pituitary adenoma. Case report. ( 15096001 )	Lyons M.K....Nelson K.D.	1996
22	Radiation-induced meningioma. ( 8608584 )	Dweik A....Jan M.	1995
23	Radiation-induced meningioma with a 63-year latency period. Case report. ( 7861229 )	Kleinschmidt-DeMasters B.K....Lillehei K.O.	1995
24	[A juvenile case of radiation-induced meningioma two years after radiation for craniopharyngioma]. ( 8164804 )	Kano T....Nakazato Y.	1994
25	Radiation-induced meningioma. ( 8166832 )	Findlay J.M....McDonald S.	1994
26	Chromosome 22 monosomy in a radiation-induced meningioma. ( 8354634 )	Pagni C.A....Ponzio G.	1993
27	A scalp lesion over an extracerebral mass: a sign of a radiation-induced meningioma. ( 1407528 )	GarcA-a Santos J.M....Climent V.	1992
28	Radiation-induced meningioma. ( 2011241 )	Sridhar K.	1991
29	Radiation-induced meningioma after treatment for pituitary adenoma: case report and literature review. ( 2407971 )	Partington M.D....Davis D.H.	1990
30	Radiation induced meningioma. A case report. ( 3716900 )	Mariotti E....Boccardo M.	1986
31	Radiation-induced meningioma: with review of literature. ( 817405 )	Waga S....Handa H.	1976

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Genes for Meningioma, Radiation-Induced

Genes related to Meningioma, Radiation-Induced (3 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	400	Pathogenic ⁶
2	NF2	Neurofibromin 2	Protein Coding	400	Pathogenic ⁶
3	MNRI	Meningioma, Radiation-Induced	Genetic Locus	58.58	Genetic linkage ⁵⁷ GeneCards inferred via : Gene name (show sections)

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Variations for Meningioma, Radiation-Induced

ClinVar genetic disease variations for Meningioma, Radiation-Induced:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	NF2	NM_000268.3(NF2): c.995delA (p.Lys332Serfs)	deletion	Pathogenic	rs587776563	GRCh37	Chromosome 22, 30064431: 30064431
2	NF2	NM_000268.3(NF2): c.995delA (p.Lys332Serfs)	deletion	Pathogenic	rs587776563	GRCh38	Chromosome 22, 29668442: 29668442
3	NF2	NM_000268.3(NF2): c.169C> T (p.Arg57Ter)	single nucleotide variant	Pathogenic	rs121434259	GRCh37	Chromosome 22, 30032794: 30032794
4	NF2	NM_000268.3(NF2): c.169C> T (p.Arg57Ter)	single nucleotide variant	Pathogenic	rs121434259	GRCh38	Chromosome 22, 29636805: 29636805
5	PDGFB	PDGFB, 135-BP DEL, IVS5	deletion	Pathogenic

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Expression for Meningioma, Radiation-Induced

Search GEO for disease gene expression data for Meningioma, Radiation-Induced.

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Pathways for Meningioma, Radiation-Induced

Pathways related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Glioblastoma Multiforme ⁶⁴	10.67	NF2 PDGFB

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GO Terms for Meningioma, Radiation-Induced

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Sources for Meningioma, Radiation-Induced

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⁷⁶ Wikipedia