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MNRI
MCID: MNN042
MIFTS: 52

Meningioma, Radiation-Induced (MNRI)

Categories: Endocrine diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Meningioma, Radiation-Induced

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MalaCards integrated aliases for Meningioma, Radiation-Induced:

Name: Meningioma, Radiation-Induced 58 13
Radiation Induced Meningioma 54 74
Meningioma 60 74
Mnri 58 54
Meningioma, Benign, No Icd-O Subtype 74

Characteristics:

Orphanet epidemiological data:

60
meningioma
Prevalence: 1-9/100000 (United States),1-9/1000000 (Europe),1-9/100000 (Europe); Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 35
Orphanet: 60  
Rare neurological diseases
Rare endocrine diseases


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Summaries for Meningioma, Radiation-Induced

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MalaCards based summary : Meningioma, Radiation-Induced, also known as radiation induced meningioma, is related to secretory meningioma and transitional meningioma. An important gene associated with Meningioma, Radiation-Induced is NF2 (Neurofibromin 2), and among its related pathways/superpathways are MicroRNAs in cancer and Interleukin-4 and 13 signaling. Affiliated tissues include pituitary, testes and brain, and related phenotypes are chromosomal breakage induced by ionizing radiation and increased sensitivity to ionizing radiation

Description from OMIM: 606190
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Related Diseases for Meningioma, Radiation-Induced

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Diseases related to Meningioma, Radiation-Induced via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 633)
# Related Disease Score Top Affiliating Genes
1 secretory meningioma 34.0 MUC1 VIM
2 transitional meningioma 33.9 MUC1 NF2
3 olfactory groove meningioma 33.7 NF2 PGR
4 rhabdoid meningioma 33.7 GFAP NF2 VIM
5 intraventricular meningioma 33.7 GFAP NF2
6 cerebral convexity meningioma 33.5 GFAP NF2
7 fibrous meningioma 33.5 MUC1 NF2 S100B VIM
8 meningioma, familial 33.4 EPB41L3 GFAP MKI67 MN1 NF2 PCNA
9 clear cell meningioma 33.3 GFAP MUC1 PGR VIM
10 suprasellar meningioma 33.3 GFAP PGR
11 chordoid meningioma 33.3 GFAP MUC1 S100B VIM
12 hemangiopericytoma, malignant 33.1 MUC1 S100B VIM
13 benign meningioma 33.0 EPB41L3 MKI67 NF2 PCNA PGR
14 neurofibromatosis, type ii 32.1 EPB41L3 EZR MSN NF2 RDX
15 endometriosis 30.7 H19 MIR200A PGR
16 cavernous hemangioma 30.6 MKI67 MUC1 VIM
17 neurofibroma 30.5 MUC1 NF2 S100B
18 neuroma 30.4 GFAP NF2 S100B
19 benign ependymoma 30.3 EPB41L3 GFAP NF2
20 spinal cord ependymoma 30.1 EPB41L3 NF2
21 pituitary carcinoma 30.0 GFAP MEG3
22 perineurioma 29.9 MUC1 S100B VIM
23 malignant fibroxanthoma 29.9 MKI67 MUC1 S100B VIM
24 leiomyosarcoma 29.9 PGR S100B VIM
25 ependymoma 29.9 GFAP MKI67 MUC1 NF2 S100B VIM
26 non-functioning pituitary adenoma 29.9 MUC1 S100B
27 neurilemmoma 29.9 EZR GFAP MSN NF2 S100B VIM
28 optic nerve glioma 29.8 GFAP MUC1 S100B VIM
29 chordoma 29.8 GFAP MUC1 S100B VIM
30 papilloma of choroid plexus 29.8 GFAP MUC1 S100B
31 hemangioblastoma 29.8 EZR GFAP MUC1 S100B
32 tuberous sclerosis 29.8 GFAP S100B VIM
33 dermoid cyst 29.8 MUC1 PGR VIM
34 gliosarcoma 29.8 GFAP S100B VIM
35 dermatofibrosarcoma protuberans 29.7 PDGFB S100B VIM
36 oligodendroglioma 29.7 GFAP PCNA PDGFB S100B
37 myxopapillary ependymoma 29.6 GFAP MUC1 S100B VIM
38 spindle cell sarcoma 29.6 MUC1 NF2 S100B VIM
39 adenoid cystic carcinoma 29.6 MKI67 MUC1 PGR S100B VIM
40 anaplastic ependymoma 29.5 GFAP MUC1 NF2 S100B VIM
41 ewing sarcoma 28.9 EZR GFAP PDGFB S100B VIM
42 spinal meningioma 12.6
43 optic nerve sheath meningioma 12.4
44 intraorbital meningioma 12.3
45 childhood brain meningioma 12.2
46 lung meningioma 12.2
47 brain meningioma 12.2
48 lymphoplasmacyte-rich meningioma 12.1
49 meningothelial meningioma 12.1
50 cerebral meningioma 12.1

Graphical network of the top 20 diseases related to Meningioma, Radiation-Induced:



Diseases related to Meningioma, Radiation-Induced
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Symptoms & Phenotypes for Meningioma, Radiation-Induced

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Human phenotypes related to Meningioma, Radiation-Induced:

60 33 (show top 50) (show all 76)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 chromosomal breakage induced by ionizing radiation 60 33 hallmark (90%) Very frequent (99-80%) HP:0010997
2 increased sensitivity to ionizing radiation 60 33 hallmark (90%) Very frequent (99-80%) HP:0011133
3 intracranial meningioma 60 33 hallmark (90%) Very frequent (99-80%) HP:0100009
4 nausea and vomiting 60 33 frequent (33%) Frequent (79-30%) HP:0002017
5 hypogonadotrophic hypogonadism 60 33 frequent (33%) Frequent (79-30%) HP:0000044
6 headache 60 33 frequent (33%) Frequent (79-30%) HP:0002315
7 secondary growth hormone deficiency 60 33 frequent (33%) Frequent (79-30%) HP:0008240
8 impotence 60 33 frequent (33%) Frequent (79-30%) HP:0000802
9 decreased circulating cortisol level 60 33 frequent (33%) Frequent (79-30%) HP:0008163
10 decreased serum estradiol 60 33 frequent (33%) Frequent (79-30%) HP:0008214
11 decreased testosterone in males 60 33 frequent (33%) Frequent (79-30%) HP:0008230
12 pituitary hypothyroidism 60 33 frequent (33%) Frequent (79-30%) HP:0008245
13 decreased circulating acth level 60 33 frequent (33%) Frequent (79-30%) HP:0002920
14 bitemporal hemianopia 60 33 frequent (33%) Frequent (79-30%) HP:0030521
15 prolactin excess 60 33 frequent (33%) Frequent (79-30%) HP:0000870
16 abnormal brain fdg positron emission tomography 60 33 frequent (33%) Frequent (79-30%) HP:0012658
17 amenorrhea 60 33 frequent (33%) Frequent (79-30%) HP:0000141
18 focal t2 hypointense thalamic lesion 60 33 frequent (33%) Frequent (79-30%) HP:0012691
19 decreased circulating follicle stimulating hormone level 60 33 frequent (33%) Frequent (79-30%) HP:0030341
20 decreased circulating luteinizing hormone level 60 33 frequent (33%) Frequent (79-30%) HP:0030344
21 focal-onset seizure 33 frequent (33%) HP:0007359
22 obesity 60 33 occasional (7.5%) Occasional (29-5%) HP:0001513
23 hydrocephalus 60 33 occasional (7.5%) Occasional (29-5%) HP:0000238
24 ataxia 60 33 occasional (7.5%) Occasional (29-5%) HP:0001251
25 facial palsy 60 33 occasional (7.5%) Occasional (29-5%) HP:0010628
26 increased intracranial pressure 60 33 occasional (7.5%) Occasional (29-5%) HP:0002516
27 ophthalmoplegia 60 33 occasional (7.5%) Occasional (29-5%) HP:0000602
28 papilledema 60 33 occasional (7.5%) Occasional (29-5%) HP:0001085
29 difficulty walking 60 33 occasional (7.5%) Occasional (29-5%) HP:0002355
30 slow decrease in visual acuity 60 33 occasional (7.5%) Occasional (29-5%) HP:0007924
31 abnormality of the sense of smell 60 33 occasional (7.5%) Occasional (29-5%) HP:0004408
32 upper limb muscle weakness 60 33 occasional (7.5%) Occasional (29-5%) HP:0003484
33 lower limb muscle weakness 60 33 occasional (7.5%) Occasional (29-5%) HP:0007340
34 hemiparesis 60 33 occasional (7.5%) Occasional (29-5%) HP:0001269
35 abnormal kinetic perimetry test 60 33 occasional (7.5%) Occasional (29-5%) HP:0030591
36 oculomotor nerve palsy 60 33 occasional (7.5%) Occasional (29-5%) HP:0012246
37 neurofibromas 60 33 occasional (7.5%) Occasional (29-5%) HP:0001067
38 weak extraocular muscles 60 33 occasional (7.5%) Occasional (29-5%) HP:0007715
39 prolactin deficiency 60 33 occasional (7.5%) Occasional (29-5%) HP:0008202
40 hypothalamic hypothyroidism 60 33 occasional (7.5%) Occasional (29-5%) HP:0008237
41 abnormality of central sensory function 60 33 occasional (7.5%) Occasional (29-5%) HP:0011730
42 neoplasm of the anterior pituitary 60 33 occasional (7.5%) Occasional (29-5%) HP:0011750
43 enlarged pituitary gland 60 33 occasional (7.5%) Occasional (29-5%) HP:0012505
44 visual acuity test abnormality 60 33 occasional (7.5%) Occasional (29-5%) HP:0030532
45 spinal meningioma 60 33 occasional (7.5%) Occasional (29-5%) HP:0100010
46 trigeminal neuralgia 60 33 occasional (7.5%) Occasional (29-5%) HP:0100661
47 abnormal cerebellum morphology 33 occasional (7.5%) HP:0001317
48 emotional lability 60 33 very rare (1%) Very rare (<4-1%) HP:0000712
49 neurological speech impairment 60 33 very rare (1%) Very rare (<4-1%) HP:0002167
50 blindness 60 33 very rare (1%) Very rare (<4-1%) HP:0000618

Clinical features from OMIM:

606190

GenomeRNAi Phenotypes related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 9.02 ALPL MUC1 NF2 RDX VIM

MGI Mouse Phenotypes related to Meningioma, Radiation-Induced:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.85 ALPL EPB41L3 GFAP MN1 NF2 NOS2
2 mortality/aging MP:0010768 9.73 ALPL EPB41L3 EZR GFAP MN1 NF2
3 reproductive system MP:0005389 9.28 ALPL EPB41L3 NF2 NOS2 PCNA PDGFB
Sources

Drugs & Therapeutics for Meningioma, Radiation-Induced

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Search Clinical Trials , NIH Clinical Center for Meningioma, Radiation-Induced

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Genetic Tests for Meningioma, Radiation-Induced

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Anatomical Context for Meningioma, Radiation-Induced

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MalaCards organs/tissues related to Meningioma, Radiation-Induced:

42
Pituitary, Testes, Brain, Cerebellum, Skin, Tongue, Hypothalamus
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Publications for Meningioma, Radiation-Induced

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Articles related to Meningioma, Radiation-Induced:

(show all 28)
# Title Authors Year
1
Coexistence of Radiation-Induced Meningioma and Moyamoya Syndrome 10 Years after Irradiation against Medulloblastoma: a Case Report. ( 28960048 )
2017
2
Tumor-to-tumor metastasis from pituitary carcinoma to radiation-induced meningioma. ( 22989053 )
2013
3
A radiation-induced meningioma &amp;quot;cures&amp;quot; a complex dural arteriovenous fistula. ( 23765916 )
2013
4
Metastatic olfactory neuroblastoma invading a radiation-induced meningioma. ( 21752653 )
2011
5
[Exacerbation of radiation induced meningioma due to hemorrhage after cerebral angiography: a case report]. ( 21270478 )
2011
6
Radiation-induced meningioma concealed by shunt valve artifact: case report. ( 18424999 )
2008
7
Radiation-induced meningioma. ( 18447746 )
2008
8
Radiation-induced meningioma following prophylactic radiotherapy for acute lymphoblastic leukemia in childhood. ( 17190987 )
2007
9
Radiation induced meningioma with a short latent period following high dose cranial irradiation - case report and literature review. ( 16292489 )
2006
10
High-dose radiation-induced meningioma in children - case report and critical review of the literature. ( 15744628 )
2005
11
High dose radiation induced meningioma. ( 15799195 )
2004
12
Radiation-induced meningioma: a descriptive study of 253 cases. ( 12450029 )
2002
13
Radiation-induced meningioma with a long latency period: a case report. ( 11511997 )
2001
14
Radiation-induced meningioma: a distinct molecular genetic pattern? ( 10901233 )
2000
15
Radiation-induced meningioma evaluated with positron emission tomography with fludeoxyglucose F 18. ( 8733970 )
1996
16
Advanced nasopharyngeal carcinoma and radiation-induced meningioma in dizygotic twins--a rare case report. ( 8938229 )
1996
17
Radiation-induced meningioma in children: report of two cases and review of the literature. ( 8753667 )
1996
18
Radiation-induced meningioma following radiation therapy for pituitary adenoma. Case report. ( 15096001 )
1996
19
Radiation-induced meningioma. ( 8608584 )
1995
20
Radiation-induced meningioma with a 63-year latency period. Case report. ( 7861229 )
1995
21
[A juvenile case of radiation-induced meningioma two years after radiation for craniopharyngioma]. ( 8164804 )
1994
22
Radiation-induced meningioma. ( 8166832 )
1994
23
Chromosome 22 monosomy in a radiation-induced meningioma. ( 8354634 )
1993
24
A scalp lesion over an extracerebral mass: a sign of a radiation-induced meningioma. ( 1407528 )
1992
25
Radiation-induced meningioma. ( 2011241 )
1991
26
Radiation-induced meningioma after treatment for pituitary adenoma: case report and literature review. ( 2407971 )
1990
27
Radiation induced meningioma. A case report. ( 3716900 )
1986
28
Radiation-induced meningioma: with review of literature. ( 817405 )
1976
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Variations for Meningioma, Radiation-Induced

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ClinVar genetic disease variations for Meningioma, Radiation-Induced:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 NF2 NM_000268.3(NF2): c.995delA (p.Lys332Serfs) deletion Pathogenic rs587776563 GRCh37 Chromosome 22, 30064431: 30064431
2 NF2 NM_000268.3(NF2): c.995delA (p.Lys332Serfs) deletion Pathogenic rs587776563 GRCh38 Chromosome 22, 29668442: 29668442
3 NF2 NM_000268.3(NF2): c.169C> T (p.Arg57Ter) single nucleotide variant Pathogenic rs121434259 GRCh37 Chromosome 22, 30032794: 30032794
4 NF2 NM_000268.3(NF2): c.169C> T (p.Arg57Ter) single nucleotide variant Pathogenic rs121434259 GRCh38 Chromosome 22, 29636805: 29636805
5 PTEN NM_000314.6(PTEN): c.701G> A (p.Arg234Gln) single nucleotide variant Uncertain significance rs121909235 GRCh37 Chromosome 10, 89717676: 89717676
6 PTEN NM_000314.6(PTEN): c.701G> A (p.Arg234Gln) single nucleotide variant Uncertain significance rs121909235 GRCh38 Chromosome 10, 87957919: 87957919
7 PDGFB PDGFB, 135-BP DEL, IVS5 deletion Pathogenic

Copy number variations for Meningioma, Radiation-Induced from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 81307 14 101400000 103200000 Loss Meningioma
2 109410 17 25800000 38100000 Copy number HER-2 Meningioma
3 116388 17 6500000 10700000 Copy number TP53 Meningioma
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Expression for Meningioma, Radiation-Induced

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Search GEO for disease gene expression data for Meningioma, Radiation-Induced.
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Pathways for Meningioma, Radiation-Induced

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Pathways related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
MicroRNAs in cancer 38
12.2 EZR MIR200A PDGFB RDX VIM
2
Interleukin-4 and 13 signaling 67
11.73 MUC1 NOS2 VIM
3
Signaling by ERBB4 67
Show member pathways
 11.69 GFAP PGR S100B
4
Cytoskeletal Signaling 4
11.59 EZR MSN MUC1 NF2 RDX VIM
5
Tight junction 38
11.58 EZR MSN NF2 PCNA RDX
6
Endocytic Trafficking of EGFR 65
Show member pathways
 11.52 EZR MSN RDX
7
Primary Focal Segmental Glomerulosclerosis FSGS 1
11.48 MKI67 PCNA VIM
8
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.46 GFAP PDGFB S100B VIM
9
AGE/RAGE pathway 1
11.28 ALPL EZR MSN NOS2
10
RhoA signaling pathway 1
11.19 EZR MSN RDX
11
G-protein signaling_Rap2B regulation pathway 23
10.75 EZR GFAP MSN PDGFB RDX VIM
Sources

GO Terms for Meningioma, Radiation-Induced

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Cellular components related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.99 EZR GFAP MSN NF2 RDX VIM
2 apical plasma membrane GO:0016324 9.83 EZR MSN MUC1 RDX
3 cell body GO:0044297 9.65 EZR GFAP NF2
4 myelin sheath GO:0043209 9.62 EZR GFAP MSN RDX
5 microvillus GO:0005902 9.58 EZR MSN RDX
6 cell periphery GO:0071944 9.54 EZR MSN RDX
7 uropod GO:0001931 9.49 EZR MSN
8 astrocyte projection GO:0097449 9.46 EZR GFAP
9 ruffle GO:0001726 9.46 EZR NF2 RDX S100B
10 invadopodium GO:0071437 9.43 EZR MSN
11 cell tip GO:0051286 9.26 EZR RDX
12 apical part of cell GO:0045177 9.26 EZR MSN NF2 RDX
13 filopodium GO:0030175 8.92 EZR MSN NF2 RDX

Biological processes related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.89 EZR MSN PDGFB RDX VIM
2 regulation of cell shape GO:0008360 9.65 EPB41L3 EZR MSN RDX S100B
3 intermediate filament organization GO:0045109 9.58 GFAP VIM
4 astrocyte development GO:0014002 9.58 GFAP VIM
5 regulation of cell size GO:0008361 9.58 EZR MSN RDX
6 microvillus assembly GO:0030033 9.57 EZR RDX
7 establishment of epithelial cell apical/basal polarity GO:0045198 9.56 EZR MSN
8 protein kinase A signaling GO:0010737 9.55 EZR RDX
9 cytoskeletal anchoring at plasma membrane GO:0007016 9.54 EPB41L3 EZR
10 establishment of endothelial barrier GO:0061028 9.54 EZR MSN RDX
11 gland morphogenesis GO:0022612 9.52 EZR MSN
12 Bergmann glial cell differentiation GO:0060020 9.51 GFAP VIM
13 positive regulation of cellular protein catabolic process GO:1903364 9.5 EZR MSN RDX
14 paracrine signaling GO:0038001 9.48 PDGFB PGR
15 membrane to membrane docking GO:0022614 9.46 EZR MSN
16 intermediate filament-based process GO:0045103 9.43 GFAP VIM
17 positive regulation of early endosome to late endosome transport GO:2000643 9.33 EZR MSN RDX
18 positive regulation of protein localization to early endosome GO:1902966 9.13 EZR MSN RDX
19 regulation of organelle assembly GO:1902115 8.8 EZR MSN RDX

Molecular functions related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 EZR GFAP PCNA PDGFB PGR S100B
2 actin binding GO:0003779 9.55 EPB41L3 EZR MSN NF2 RDX
3 ATPase binding GO:0051117 9.5 EZR PGR RDX
4 S100 protein binding GO:0044548 9.37 EZR S100B
5 structural constituent of cytoskeleton GO:0005200 9.26 EPB41L3 GFAP MSN VIM
6 cytoskeletal protein binding GO:0008092 9.02 EPB41L3 EZR MSN NF2 RDX
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Sources for Meningioma, Radiation-Induced

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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