MCID: MNN042
MIFTS: 36

Meningioma, Radiation-Induced

Categories: Rare diseases, Neuronal diseases, Endocrine diseases

Aliases & Classifications for Meningioma, Radiation-Induced

MalaCards integrated aliases for Meningioma, Radiation-Induced:

Name: Meningioma, Radiation-Induced 57 13
Radiation Induced Meningioma 53 73
Meningioma 59 73
Mnri 57 53
Meningioma, Benign, No Icd-O Subtype 73

Characteristics:

Orphanet epidemiological data:

59
meningioma
Prevalence: 1-9/100000 (United States),1-9/1000000 (Europe),1-9/100000 (Europe); Age of onset: All ages;

Classifications:



External Ids:

OMIM 57 606190
Orphanet 59 ORPHA2495
MESH via Orphanet 45 D008579
UMLS via Orphanet 74 C0025286
ICD10 via Orphanet 34 D32.9
MedGen 42 C1853554

Summaries for Meningioma, Radiation-Induced

MalaCards based summary : Meningioma, Radiation-Induced, also known as radiation induced meningioma, is related to meningioma, familial and spinal meningioma. An important gene associated with Meningioma, Radiation-Induced is PDGFB (Platelet Derived Growth Factor Subunit B), and among its related pathways/superpathways is Glioblastoma Multiforme. Affiliated tissues include pituitary, testes and brain, and related phenotypes are obesity and hydrocephalus

Description from OMIM: 606190

Related Diseases for Meningioma, Radiation-Induced

Diseases related to Meningioma, Radiation-Induced via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 469)
# Related Disease Score Top Affiliating Genes
1 meningioma, familial 32.5 NF2 PDGFB
2 spinal meningioma 12.3
3 optic nerve sheath meningioma 12.2
4 intraorbital meningioma 12.1
5 rhabdoid meningioma 12.0
6 lung meningioma 12.0
7 benign meningioma 12.0
8 secretory meningioma 12.0
9 lymphoplasmacyte-rich meningioma 11.9
10 cerebral meningioma 11.9
11 chordoid meningioma 11.9
12 fibrous meningioma 11.9
13 transitional meningioma 11.9
14 tuberculum sellae meningioma 11.9
15 skull base meningioma 11.9
16 olfactory groove meningioma 11.9
17 cerebellopontine angle meningioma 11.9
18 foramen magnum meningioma 11.9
19 cavernous sinus meningioma 11.9
20 meningothelial meningioma 11.9
21 clear cell meningioma 11.9
22 brain meningioma 11.9
23 pineal region meningioma 11.9
24 parasagittal meningioma 11.9
25 petrous apex meningioma 11.9
26 intraventricular meningioma 11.9
27 anterior cranial fossa meningioma 11.9
28 clivus meningioma 11.9
29 cerebral falx meningioma 11.9
30 petroclival meningioma 11.9
31 choroid plexus meningioma 11.9
32 middle cranial fossa meningioma 11.9
33 microcystic meningioma 11.9
34 suprasellar meningioma 11.9
35 angiomatous meningioma 11.9
36 jugular foramen meningioma 11.9
37 sphenoorbital meningioma 11.9
38 psammomatous meningioma 11.9
39 parapharyngeal meningioma 11.9
40 diaphragma sellae meningioma 11.9
41 lateral ventricle meningioma 11.9
42 brainstem intraparenchymal clear cell meningioma 11.9
43 anterior foramen magnum meningioma 11.9
44 frontal convexity meningioma 11.9
45 pituitary stalk meningioma 11.9
46 pediatric meningioma 11.8
47 intracerebral cystic meningioma 11.8
48 multiple skull base meningioma 11.8
49 cerebral convexity meningioma 11.8
50 internal auditory canal meningioma 11.7

Graphical network of the top 20 diseases related to Meningioma, Radiation-Induced:



Diseases related to Meningioma, Radiation-Induced

Symptoms & Phenotypes for Meningioma, Radiation-Induced

Clinical features from OMIM:

606190

Human phenotypes related to Meningioma, Radiation-Induced:

59 (show top 50) (show all 74)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 obesity 59 Occasional (29-5%)
2 hydrocephalus 59 Occasional (29-5%)
3 emotional lability 59 Very rare (<4-1%)
4 seizures 59 Frequent (79-30%)
5 ataxia 59 Occasional (29-5%)
6 nausea and vomiting 59 Frequent (79-30%)
7 neurological speech impairment 59 Very rare (<4-1%)
8 facial palsy 59 Occasional (29-5%)
9 increased intracranial pressure 59 Occasional (29-5%)
10 blindness 59 Very rare (<4-1%)
11 cognitive impairment 59 Occasional (29-5%)
12 cranial nerve paralysis 59 Occasional (29-5%)
13 hypogonadotrophic hypogonadism 59 Frequent (79-30%)
14 memory impairment 59 Occasional (29-5%)
15 neoplasm of the skin 59 Very rare (<4-1%)
16 papilledema 59 Occasional (29-5%)
17 difficulty walking 59 Occasional (29-5%)
18 back pain 59 Very rare (<4-1%)
19 proptosis 59 Very rare (<4-1%)
20 slow decrease in visual acuity 59 Occasional (29-5%)
21 headache 59 Frequent (79-30%)
22 focal seizures 59 Frequent (79-30%)
23 tinnitus 59 Very rare (<4-1%)
24 abnormality of the sense of smell 59 Occasional (29-5%)
25 cerebral hemorrhage 59 Very rare (<4-1%)
26 abnormality of the cerebellum 59 Occasional (29-5%)
27 urinary incontinence 59 Very rare (<4-1%)
28 ophthalmoplegia 59 Occasional (29-5%)
29 secondary growth hormone deficiency 59 Frequent (79-30%)
30 syncope 59 Very rare (<4-1%)
31 impotence 59 Frequent (79-30%)
32 decreased circulating cortisol level 59 Frequent (79-30%)
33 decreased serum estradiol 59 Frequent (79-30%)
34 decreased testosterone in males 59 Frequent (79-30%)
35 pituitary hypothyroidism 59 Frequent (79-30%)
36 hemiparesis 59 Occasional (29-5%)
37 excessive daytime somnolence 59 Very rare (<4-1%)
38 functional motor problems 59 Occasional (29-5%)
39 lower limb muscle weakness 59 Occasional (29-5%)
40 decreased circulating acth level 59 Frequent (79-30%)
41 bitemporal hemianopia 59 Frequent (79-30%)
42 abnormal kinetic perimetry test 59 Occasional (29-5%)
43 oculomotor nerve palsy 59 Occasional (29-5%)
44 prolactin excess 59 Frequent (79-30%)
45 abnormal brain fdg positron emission tomography 59 Frequent (79-30%)
46 neurofibromas 59 Occasional (29-5%)
47 chromosomal breakage induced by ionizing radiation 59 Very frequent (99-80%)
48 increased sensitivity to ionizing radiation 59 Very frequent (99-80%)
49 intracranial meningioma 59 Very frequent (99-80%)
50 amenorrhea 59 Frequent (79-30%)

GenomeRNAi Phenotypes related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-2 9.1 PDGFB
2 Decreased viability GR00221-A-3 9.1 NF2 PDGFB
3 Decreased viability GR00240-S-1 9.1 PDGFB
4 Decreased viability GR00402-S-2 9.1 NF2 PDGFB

Drugs & Therapeutics for Meningioma, Radiation-Induced

Search Clinical Trials , NIH Clinical Center for Meningioma, Radiation-Induced

Genetic Tests for Meningioma, Radiation-Induced

Anatomical Context for Meningioma, Radiation-Induced

MalaCards organs/tissues related to Meningioma, Radiation-Induced:

41
Pituitary, Testes, Brain, Skin, Tongue, Hypothalamus, Cerebellum

Publications for Meningioma, Radiation-Induced

Articles related to Meningioma, Radiation-Induced:

(show all 31)
# Title Authors Year
1
Radiation-induced meningiomas after BNCT in patients with malignant glioma. ( 26122975 )
2015
2
Tumor-to-tumor metastasis from pituitary carcinoma to radiation-induced meningioma. ( 22989053 )
2013
3
A radiation-induced meningioma &amp;quot;cures&amp;quot; a complex dural arteriovenous fistula. ( 23765916 )
2013
4
Metastatic olfactory neuroblastoma invading a radiation-induced meningioma. ( 21752653 )
2011
5
[Exacerbation of radiation induced meningioma due to hemorrhage after cerebral angiography: a case report]. ( 21270478 )
2011
6
Radiation-induced meningiomas: a shadow in the success story of childhood leukemia. ( 19179425 )
2009
7
Radiation-induced meningioma concealed by shunt valve artifact: case report. ( 18424999 )
2008
8
Radiation-induced meningiomas: clinical, cytogenetic, and microarray features. ( 18604545 )
2008
9
Radiation-induced meningioma. ( 18447746 )
2008
10
Radiation-induced meningioma following prophylactic radiotherapy for acute lymphoblastic leukemia in childhood. ( 17190987 )
2007
11
Radiation induced meningioma with a short latent period following high dose cranial irradiation - case report and literature review. ( 16292489 )
2006
12
High-dose radiation-induced meningioma in children - case report and critical review of the literature. ( 15744628 )
2005
13
High dose radiation induced meningioma. ( 15799195 )
2004
14
Radiation-induced meningiomas: clinical, pathological, cytokinetic, and cytogenetic characteristics. ( 15200115 )
2004
15
Radiation-induced meningioma: a descriptive study of 253 cases. ( 12450029 )
2002
16
Radiation-induced meningioma with a long latency period: a case report. ( 11511997 )
2001
17
Radiation-induced meningioma: a distinct molecular genetic pattern? ( 10901233 )
2000
18
Radiation-induced meningioma evaluated with positron emission tomography with fludeoxyglucose F 18. ( 8733970 )
1996
19
Advanced nasopharyngeal carcinoma and radiation-induced meningioma in dizygotic twins--a rare case report. ( 8938229 )
1996
20
Radiation-induced meningioma in children: report of two cases and review of the literature. ( 8753667 )
1996
21
Radiation-induced meningioma following radiation therapy for pituitary adenoma. Case report. ( 15096001 )
1996
22
Radiation-induced meningioma. ( 8608584 )
1995
23
Radiation-induced meningioma with a 63-year latency period. Case report. ( 7861229 )
1995
24
[A juvenile case of radiation-induced meningioma two years after radiation for craniopharyngioma]. ( 8164804 )
1994
25
Radiation-induced meningioma. ( 8166832 )
1994
26
Chromosome 22 monosomy in a radiation-induced meningioma. ( 8354634 )
1993
27
A scalp lesion over an extracerebral mass: a sign of a radiation-induced meningioma. ( 1407528 )
1992
28
Radiation-induced meningioma. ( 2011241 )
1991
29
Radiation-induced meningioma after treatment for pituitary adenoma: case report and literature review. ( 2407971 )
1990
30
Radiation induced meningioma. A case report. ( 3716900 )
1986
31
Radiation-induced meningioma: with review of literature. ( 817405 )
1976

Variations for Meningioma, Radiation-Induced

ClinVar genetic disease variations for Meningioma, Radiation-Induced:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 NF2 NM_000268.3(NF2): c.995delA (p.Lys332Serfs) deletion Pathogenic rs587776563 GRCh37 Chromosome 22, 30064431: 30064431
2 NF2 NM_000268.3(NF2): c.995delA (p.Lys332Serfs) deletion Pathogenic rs587776563 GRCh38 Chromosome 22, 29668442: 29668442
3 NF2 NM_000268.3(NF2): c.169C> T (p.Arg57Ter) single nucleotide variant Pathogenic rs121434259 GRCh37 Chromosome 22, 30032794: 30032794
4 NF2 NM_000268.3(NF2): c.169C> T (p.Arg57Ter) single nucleotide variant Pathogenic rs121434259 GRCh38 Chromosome 22, 29636805: 29636805
5 PDGFB PDGFB, 135-BP DEL, IVS5 deletion Pathogenic

Expression for Meningioma, Radiation-Induced

Search GEO for disease gene expression data for Meningioma, Radiation-Induced.

Pathways for Meningioma, Radiation-Induced

Pathways related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.67 NF2 PDGFB

GO Terms for Meningioma, Radiation-Induced

Sources for Meningioma, Radiation-Induced

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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