MNRI
MCID: MNN042
MIFTS: 52

Meningioma, Radiation-Induced (MNRI)

Categories: Endocrine diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Meningioma, Radiation-Induced

MalaCards integrated aliases for Meningioma, Radiation-Induced:

Name: Meningioma, Radiation-Induced 57 13
Radiation Induced Meningioma 53 73
Meningioma 59 73
Mnri 57 53
Meningioma, Benign, No Icd-O Subtype 73

Characteristics:

Orphanet epidemiological data:

59
meningioma
Prevalence: 1-9/100000 (United States),1-9/1000000 (Europe),1-9/100000 (Europe); Age of onset: All ages;

Classifications:



Summaries for Meningioma, Radiation-Induced

MalaCards based summary : Meningioma, Radiation-Induced, also known as radiation induced meningioma, is related to secretory meningioma and meningioma, familial. An important gene associated with Meningioma, Radiation-Induced is NF2 (Neurofibromin 2), and among its related pathways/superpathways are MicroRNAs in cancer and Interleukin-4 and 13 signaling. Affiliated tissues include pituitary, brain and testes, and related phenotypes are obesity and hydrocephalus

Description from OMIM: 606190

Related Diseases for Meningioma, Radiation-Induced

Diseases related to Meningioma, Radiation-Induced via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 592)
# Related Disease Score Top Affiliating Genes
1 secretory meningioma 33.7 MUC1 VIM
2 meningioma, familial 33.7 EPB41L3 GFAP MKI67 MN1 NF2 PCNA
3 transitional meningioma 33.6 MUC1 NF2
4 olfactory groove meningioma 33.5 NF2 PGR
5 rhabdoid meningioma 33.5 GFAP NF2 VIM
6 intraventricular meningioma 33.4 GFAP NF2
7 fibrous meningioma 33.3 MUC1 NF2 S100B VIM
8 cerebral convexity meningioma 33.2 GFAP NF2
9 clear cell meningioma 33.2 GFAP MUC1 PGR VIM
10 chordoid meningioma 33.2 GFAP MUC1 S100B VIM
11 suprasellar meningioma 33.1 GFAP PGR
12 benign meningioma 33.1 EPB41L3 MKI67 NF2 PCNA PGR
13 hemangiopericytoma, malignant 32.9 MUC1 S100B VIM
14 neurofibromatosis, type ii 32.1 EPB41L3 EZR MSN NF2 RDX
15 endometriosis 30.6 H19 MIR200A PGR
16 cavernous hemangioma 30.4 MKI67 MUC1 VIM
17 neurofibroma 30.4 MUC1 NF2 S100B
18 neuroma 30.2 GFAP NF2 S100B
19 neurilemmoma 30.0 EZR GFAP MSN NF2 S100B VIM
20 ependymoma 29.9 GFAP MKI67 MUC1 NF2 S100B VIM
21 malignant fibroxanthoma 29.9 MKI67 MUC1 S100B VIM
22 hemangioblastoma 29.8 EZR GFAP MUC1 S100B
23 benign ependymoma 29.8 EPB41L3 GFAP NF2
24 optic nerve glioma 29.8 GFAP MUC1 S100B VIM
25 chordoma 29.8 GFAP MUC1 S100B VIM
26 perineurioma 29.8 MUC1 S100B VIM
27 spinal cord ependymoma 29.8 EPB41L3 NF2
28 oligodendroglioma 29.8 GFAP PCNA PDGFB S100B
29 papilloma of choroid plexus 29.7 GFAP MUC1 S100B
30 gliosarcoma 29.7 GFAP S100B VIM
31 non-functioning pituitary adenoma 29.7 MUC1 S100B
32 dermoid cyst 29.6 MUC1 PGR VIM
33 tuberous sclerosis 29.6 GFAP S100B VIM
34 myxopapillary ependymoma 29.6 GFAP MUC1 S100B VIM
35 dermatofibrosarcoma protuberans 29.6 PDGFB S100B VIM
36 anaplastic ependymoma 29.5 GFAP MUC1 NF2 S100B VIM
37 adenoid cystic carcinoma 29.3 MKI67 MUC1 PGR S100B VIM
38 ewing sarcoma 29.1 EZR GFAP PDGFB S100B VIM
39 spinal meningioma 12.5
40 optic nerve sheath meningioma 12.3
41 intraorbital meningioma 12.3
42 childhood brain meningioma 12.2
43 lung meningioma 12.1
44 brain meningioma 12.1
45 lymphoplasmacyte-rich meningioma 12.1
46 cerebral meningioma 12.1
47 tuberculum sellae meningioma 12.1
48 skull base meningioma 12.1
49 foramen magnum meningioma 12.1
50 cerebellopontine angle meningioma 12.1

Graphical network of the top 20 diseases related to Meningioma, Radiation-Induced:



Diseases related to Meningioma, Radiation-Induced

Symptoms & Phenotypes for Meningioma, Radiation-Induced

Clinical features from OMIM:

606190

Human phenotypes related to Meningioma, Radiation-Induced:

59 32 (show top 50) (show all 76)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 obesity 59 32 occasional (7.5%) Occasional (29-5%) HP:0001513
2 hydrocephalus 59 32 occasional (7.5%) Occasional (29-5%) HP:0000238
3 emotional lability 59 32 very rare (1%) Very rare (<4-1%) HP:0000712
4 ataxia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001251
5 nausea and vomiting 59 32 frequent (33%) Frequent (79-30%) HP:0002017
6 neurological speech impairment 59 32 very rare (1%) Very rare (<4-1%) HP:0002167
7 facial palsy 59 32 occasional (7.5%) Occasional (29-5%) HP:0010628
8 increased intracranial pressure 59 32 occasional (7.5%) Occasional (29-5%) HP:0002516
9 blindness 59 32 very rare (1%) Very rare (<4-1%) HP:0000618
10 hypogonadotrophic hypogonadism 59 32 frequent (33%) Frequent (79-30%) HP:0000044
11 back pain 59 32 very rare (1%) Very rare (<4-1%) HP:0003418
12 papilledema 59 32 occasional (7.5%) Occasional (29-5%) HP:0001085
13 difficulty walking 59 32 occasional (7.5%) Occasional (29-5%) HP:0002355
14 proptosis 59 32 very rare (1%) Very rare (<4-1%) HP:0000520
15 slow decrease in visual acuity 59 32 occasional (7.5%) Occasional (29-5%) HP:0007924
16 headache 59 32 frequent (33%) Frequent (79-30%) HP:0002315
17 tinnitus 59 32 very rare (1%) Very rare (<4-1%) HP:0000360
18 abnormality of the sense of smell 59 32 occasional (7.5%) Occasional (29-5%) HP:0004408
19 cerebral hemorrhage 59 32 very rare (1%) Very rare (<4-1%) HP:0001342
20 ophthalmoplegia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000602
21 upper limb muscle weakness 59 32 occasional (7.5%) Occasional (29-5%) HP:0003484
22 lower limb muscle weakness 59 32 occasional (7.5%) Occasional (29-5%) HP:0007340
23 urinary incontinence 59 32 very rare (1%) Very rare (<4-1%) HP:0000020
24 secondary growth hormone deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0008240
25 syncope 59 32 very rare (1%) Very rare (<4-1%) HP:0001279
26 impotence 59 32 frequent (33%) Frequent (79-30%) HP:0000802
27 decreased circulating cortisol level 59 32 frequent (33%) Frequent (79-30%) HP:0008163
28 decreased serum estradiol 59 32 frequent (33%) Frequent (79-30%) HP:0008214
29 decreased testosterone in males 59 32 frequent (33%) Frequent (79-30%) HP:0008230
30 pituitary hypothyroidism 59 32 frequent (33%) Frequent (79-30%) HP:0008245
31 hemiparesis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001269
32 excessive daytime somnolence 59 32 very rare (1%) Very rare (<4-1%) HP:0001262
33 decreased circulating acth level 59 32 frequent (33%) Frequent (79-30%) HP:0002920
34 bitemporal hemianopia 59 32 frequent (33%) Frequent (79-30%) HP:0030521
35 abnormal kinetic perimetry test 59 32 occasional (7.5%) Occasional (29-5%) HP:0030591
36 oculomotor nerve palsy 59 32 occasional (7.5%) Occasional (29-5%) HP:0012246
37 prolactin excess 59 32 frequent (33%) Frequent (79-30%) HP:0000870
38 abnormal brain fdg positron emission tomography 59 32 frequent (33%) Frequent (79-30%) HP:0012658
39 neurofibromas 59 32 occasional (7.5%) Occasional (29-5%) HP:0001067
40 chromosomal breakage induced by ionizing radiation 59 32 hallmark (90%) Very frequent (99-80%) HP:0010997
41 increased sensitivity to ionizing radiation 59 32 hallmark (90%) Very frequent (99-80%) HP:0011133
42 intracranial meningioma 59 32 hallmark (90%) Very frequent (99-80%) HP:0100009
43 amenorrhea 59 32 frequent (33%) Frequent (79-30%) HP:0000141
44 focal t2 hypointense thalamic lesion 59 32 frequent (33%) Frequent (79-30%) HP:0012691
45 decreased circulating follicle stimulating hormone level 59 32 frequent (33%) Frequent (79-30%) HP:0030341
46 decreased circulating luteinizing hormone level 59 32 frequent (33%) Frequent (79-30%) HP:0030344
47 weak extraocular muscles 59 32 occasional (7.5%) Occasional (29-5%) HP:0007715
48 prolactin deficiency 59 32 occasional (7.5%) Occasional (29-5%) HP:0008202
49 hypothalamic hypothyroidism 59 32 occasional (7.5%) Occasional (29-5%) HP:0008237
50 abnormality of central sensory function 59 32 occasional (7.5%) Occasional (29-5%) HP:0011730

GenomeRNAi Phenotypes related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 9.02 ALPL MUC1 NF2 RDX VIM

MGI Mouse Phenotypes related to Meningioma, Radiation-Induced:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.85 ALPL EPB41L3 GFAP MN1 NF2 NOS2
2 mortality/aging MP:0010768 9.73 ALPL EPB41L3 EZR GFAP MN1 NF2
3 reproductive system MP:0005389 9.28 ALPL EPB41L3 NF2 NOS2 PCNA PDGFB

Drugs & Therapeutics for Meningioma, Radiation-Induced

Search Clinical Trials , NIH Clinical Center for Meningioma, Radiation-Induced

Genetic Tests for Meningioma, Radiation-Induced

Anatomical Context for Meningioma, Radiation-Induced

MalaCards organs/tissues related to Meningioma, Radiation-Induced:

41
Pituitary, Brain, Testes, Cerebellum, Lung, Spinal Cord, Thyroid

Publications for Meningioma, Radiation-Induced

Articles related to Meningioma, Radiation-Induced:

(show all 28)
# Title Authors Year
1
Coexistence of Radiation-Induced Meningioma and Moyamoya Syndrome 10 Years after Irradiation against Medulloblastoma: a Case Report. ( 28960048 )
2017
2
Tumor-to-tumor metastasis from pituitary carcinoma to radiation-induced meningioma. ( 22989053 )
2013
3
A radiation-induced meningioma &amp;quot;cures&amp;quot; a complex dural arteriovenous fistula. ( 23765916 )
2013
4
Metastatic olfactory neuroblastoma invading a radiation-induced meningioma. ( 21752653 )
2011
5
[Exacerbation of radiation induced meningioma due to hemorrhage after cerebral angiography: a case report]. ( 21270478 )
2011
6
Radiation-induced meningioma concealed by shunt valve artifact: case report. ( 18424999 )
2008
7
Radiation-induced meningioma. ( 18447746 )
2008
8
Radiation-induced meningioma following prophylactic radiotherapy for acute lymphoblastic leukemia in childhood. ( 17190987 )
2007
9
Radiation induced meningioma with a short latent period following high dose cranial irradiation - case report and literature review. ( 16292489 )
2006
10
High-dose radiation-induced meningioma in children - case report and critical review of the literature. ( 15744628 )
2005
11
High dose radiation induced meningioma. ( 15799195 )
2004
12
Radiation-induced meningioma: a descriptive study of 253 cases. ( 12450029 )
2002
13
Radiation-induced meningioma with a long latency period: a case report. ( 11511997 )
2001
14
Radiation-induced meningioma: a distinct molecular genetic pattern? ( 10901233 )
2000
15
Radiation-induced meningioma evaluated with positron emission tomography with fludeoxyglucose F 18. ( 8733970 )
1996
16
Advanced nasopharyngeal carcinoma and radiation-induced meningioma in dizygotic twins--a rare case report. ( 8938229 )
1996
17
Radiation-induced meningioma in children: report of two cases and review of the literature. ( 8753667 )
1996
18
Radiation-induced meningioma following radiation therapy for pituitary adenoma. Case report. ( 15096001 )
1996
19
Radiation-induced meningioma. ( 8608584 )
1995
20
Radiation-induced meningioma with a 63-year latency period. Case report. ( 7861229 )
1995
21
[A juvenile case of radiation-induced meningioma two years after radiation for craniopharyngioma]. ( 8164804 )
1994
22
Radiation-induced meningioma. ( 8166832 )
1994
23
Chromosome 22 monosomy in a radiation-induced meningioma. ( 8354634 )
1993
24
A scalp lesion over an extracerebral mass: a sign of a radiation-induced meningioma. ( 1407528 )
1992
25
Radiation-induced meningioma. ( 2011241 )
1991
26
Radiation-induced meningioma after treatment for pituitary adenoma: case report and literature review. ( 2407971 )
1990
27
Radiation induced meningioma. A case report. ( 3716900 )
1986
28
Radiation-induced meningioma: with review of literature. ( 817405 )
1976

Variations for Meningioma, Radiation-Induced

ClinVar genetic disease variations for Meningioma, Radiation-Induced:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 NF2 NM_000268.3(NF2): c.995delA (p.Lys332Serfs) deletion Pathogenic rs587776563 GRCh37 Chromosome 22, 30064431: 30064431
2 NF2 NM_000268.3(NF2): c.995delA (p.Lys332Serfs) deletion Pathogenic rs587776563 GRCh38 Chromosome 22, 29668442: 29668442
3 NF2 NM_000268.3(NF2): c.169C> T (p.Arg57Ter) single nucleotide variant Pathogenic rs121434259 GRCh37 Chromosome 22, 30032794: 30032794
4 NF2 NM_000268.3(NF2): c.169C> T (p.Arg57Ter) single nucleotide variant Pathogenic rs121434259 GRCh38 Chromosome 22, 29636805: 29636805
5 PTEN NM_000314.6(PTEN): c.701G> A (p.Arg234Gln) single nucleotide variant Uncertain significance rs121909235 GRCh37 Chromosome 10, 89717676: 89717676
6 PTEN NM_000314.6(PTEN): c.701G> A (p.Arg234Gln) single nucleotide variant Uncertain significance rs121909235 GRCh38 Chromosome 10, 87957919: 87957919
7 PDGFB PDGFB, 135-BP DEL, IVS5 deletion Pathogenic

Copy number variations for Meningioma, Radiation-Induced from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 81307 14 101400000 103200000 Loss Meningioma
2 109410 17 25800000 38100000 Copy number HER-2 Meningioma
3 116388 17 6500000 10700000 Copy number TP53 Meningioma

Expression for Meningioma, Radiation-Induced

Search GEO for disease gene expression data for Meningioma, Radiation-Induced.

Pathways for Meningioma, Radiation-Induced

GO Terms for Meningioma, Radiation-Induced

Cellular components related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.99 EZR GFAP MSN NF2 RDX VIM
2 apical plasma membrane GO:0016324 9.83 EZR MSN MUC1 RDX
3 cell body GO:0044297 9.65 EZR GFAP NF2
4 myelin sheath GO:0043209 9.62 EZR GFAP MSN RDX
5 microvillus GO:0005902 9.58 EZR MSN RDX
6 cell periphery GO:0071944 9.54 EZR MSN RDX
7 uropod GO:0001931 9.49 EZR MSN
8 astrocyte projection GO:0097449 9.46 EZR GFAP
9 ruffle GO:0001726 9.46 EZR NF2 RDX S100B
10 invadopodium GO:0071437 9.43 EZR MSN
11 cell tip GO:0051286 9.26 EZR RDX
12 apical part of cell GO:0045177 9.26 EZR MSN NF2 RDX
13 filopodium GO:0030175 8.92 EZR MSN NF2 RDX

Biological processes related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.89 EZR MSN PDGFB RDX VIM
2 regulation of cell shape GO:0008360 9.65 EPB41L3 EZR MSN RDX S100B
3 intermediate filament organization GO:0045109 9.58 GFAP VIM
4 astrocyte development GO:0014002 9.58 GFAP VIM
5 regulation of cell size GO:0008361 9.58 EZR MSN RDX
6 microvillus assembly GO:0030033 9.57 EZR RDX
7 establishment of epithelial cell apical/basal polarity GO:0045198 9.56 EZR MSN
8 protein kinase A signaling GO:0010737 9.55 EZR RDX
9 cytoskeletal anchoring at plasma membrane GO:0007016 9.54 EPB41L3 EZR
10 establishment of endothelial barrier GO:0061028 9.54 EZR MSN RDX
11 gland morphogenesis GO:0022612 9.52 EZR MSN
12 Bergmann glial cell differentiation GO:0060020 9.51 GFAP VIM
13 positive regulation of cellular protein catabolic process GO:1903364 9.5 EZR MSN RDX
14 paracrine signaling GO:0038001 9.48 PDGFB PGR
15 membrane to membrane docking GO:0022614 9.46 EZR MSN
16 intermediate filament-based process GO:0045103 9.43 GFAP VIM
17 positive regulation of early endosome to late endosome transport GO:2000643 9.33 EZR MSN RDX
18 positive regulation of protein localization to early endosome GO:1902966 9.13 EZR MSN RDX
19 regulation of organelle assembly GO:1902115 8.8 EZR MSN RDX

Molecular functions related to Meningioma, Radiation-Induced according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 EZR GFAP PCNA PDGFB PGR S100B
2 actin binding GO:0003779 9.55 EPB41L3 EZR MSN NF2 RDX
3 ATPase binding GO:0051117 9.5 EZR PGR RDX
4 S100 protein binding GO:0044548 9.37 EZR S100B
5 structural constituent of cytoskeleton GO:0005200 9.26 EPB41L3 GFAP MSN VIM
6 cytoskeletal protein binding GO:0008092 9.02 EPB41L3 EZR MSN NF2 RDX

Sources for Meningioma, Radiation-Induced

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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