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MCID: MNN013
MIFTS: 71

Meningitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Meningitis

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MalaCards integrated aliases for Meningitis:

Name: Meningitis 12 76 54 29 55 43 3 44 15 73

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:9471
ICD10 33 G03 G03.9 G03.8
ICD9CM 35 322 322.9
MeSH 44 D008581
NCIt 50 C26828
SNOMED-CT 68 7180009
UMLS 73 C0025289
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Summaries for Meningitis

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NINDS : 54 Meningitis is an infection of the meninges, the membranes that surround the brain and spinal cord. Encephalitis is inflammation of the brain itself. Anyone can get encephalitis or meningitis. Causes of encephalitis and meningitis include viruses, bacteria, fungus, and parasites. Anyone experiencing symptoms of meningitis or encephalitis should see a doctor immediately. Symptoms of encephalitis that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia. Other symptoms include: sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, irritability. In more severe cases, people may have problems with speech or hearing, vision problems, and hallucinations. Symptoms of meningitis, which may appear suddenly, often include: high fever, severe and persistent headache, stiff neck, nausea, sensitivity to bright light, vomiting, and changes in behavior such as confusion, sleepiness, and difficulty waking up. In infants, symptoms of meningitis or encephalitis may include fever, vomiting, lethargy, body stiffness, unexplained irritability, and a full or bulging fontanel (the soft spot on the top of the head).

MalaCards based summary : Meningitis is related to viral meningitis and aseptic meningitis, and has symptoms including seizures, tremor and fever. An important gene associated with Meningitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Phenytoin and Amphotericin B have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related phenotypes are homeostasis/metabolism and immune system

Disease Ontology : 12 A central nervous system disease that is characterized by an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells.

MedlinePlus : 43 Meningitis is inflammation of the thin tissue that surrounds the brain and spinal cord, called the meninges. There are several types of meningitis. The most common is viral meningitis. You get it when a virus enters the body through the nose or mouth and travels to the brain. Bacterial meningitis is rare, but can be deadly. It usually starts with bacteria that cause a cold-like infection. It can cause stroke, hearing loss, and brain damage. It can also harm other organs. Pneumococcal infections and meningococcal infections are the most common causes of bacterial meningitis. Anyone can get meningitis, but it is more common in people with weak immune systems. Meningitis can get serious very quickly. You should get medical care right away if you have A sudden high fever A severe headache A stiff neck Nausea or vomiting Early treatment can help prevent serious problems, including death. Tests to diagnose meningitis include blood tests, imaging tests, and a spinal tap to test cerebrospinal fluid. Antibiotics can treat bacterial meningitis. Antiviral medicines may help some types of viral meningitis. Other medicines can help treat symptoms. There are vaccines to prevent some of the bacterial infections that cause meningitis. NIH: National Institute of Neurological Disorders and Stroke

CDC : 3 Meningitis is an inflammation (swelling) of the protective membranes covering the brain and spinal cord. A bacterial or viral infection of the fluid surrounding the brain and spinal cord usually causes the swelling. However, injuries, cancer, certain drugs, and other types of infections also can cause meningitis. It is important to know the specific cause of meningitis because the treatment differs depending on the cause.

Wikipedia : 76 Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord,... more...

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Related Diseases for Meningitis

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Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1203)
# Related Disease Score Top Affiliating Genes
1 viral meningitis 34.3 CRP CXCL8 IL6
2 aseptic meningitis 34.3 CXCL8 IL10 IL1B NLRP3 TNF
3 meningococcal meningitis 34.1 CFP MBL2 TLR9
4 tuberculous meningitis 33.9 ADA CXCL8 LYZ MMP9 TLR2 TNF
5 streptococcal meningitis 33.9 CFP CRP MBL2 TNF
6 chronic meningitis 33.8 CRP MMP9 NLRP3
7 bacterial meningitis 33.2 ALB CFP CRP CXCL8 IL10 IL1B
8 listeriosis 32.8 IL6 MBL2 TNF
9 neurosyphilis 32.6 CXCL8 IL10 TLR2
10 meningoencephalitis 32.4 ALB IL6 TLR9
11 meningococcemia 32.3 CFP IL1B MBL2
12 neisseria meningitidis infection 31.9 CFP LACTB MBL2 TLR2
13 extrapulmonary tuberculosis 31.9 ADA IL10 IL1B MBL2 TLR2
14 leptospirosis 31.8 CRP CXCL8 IL10 IL1B IL6 TLR2
15 behcet syndrome 31.7 ADA CRP CXCL8 IL10 IL1B IL6
16 tuberculous peritonitis 31.5 ADA ALB CRP TNF
17 cerebral palsy 31.5 IL1B IL6 MBL2 TNF
18 haemophilus influenzae 31.1 CXCL8 IL1B TLR2 TNF
19 viral infectious disease 30.9 CCL4 CXCL8 IL10 IL1B IL6 TLR9
20 acquired immunodeficiency syndrome 30.5 ALB IL10 IL1B IL6 TNF
21 scrub typhus 30.4 CRP IL10 IL1B TLR2 TNF
22 arthritis 30.3 CXCL8 IL10 IL1B IL6 MMP9 TNF
23 lymphadenitis 30.3 CXCL8 IL10 IL1B TNF
24 purpura 30.3 CRP IL6 TNF
25 mixed connective tissue disease 30.3 IL10 IL6 TNF
26 osteomyelitis 30.2 CXCL8 IL10 IL1B IL6 TNF
27 brain edema 30.2 ALB IL1B IL6 MMP9
28 transverse myelitis 30.2 CXCL8 IL10 IL6 MMP9 TNF
29 crohn's disease 30.2 CRP IL10 TLR9 TNF
30 connective tissue disease 30.2 IL10 IL6 TLR9 TNF
31 adult-onset still's disease 30.2 CRP IL1B IL6 TNF
32 viral encephalitis 30.2 IL10 IL1B IL6 TNF
33 endocarditis 30.1 ALB CRP CXCL8 IL10 IL6 LACTB
34 human immunodeficiency virus infectious disease 30.1 CCL4 IL10 IL6 TLR9 TNF
35 suppurative otitis media 30.1 CRP IL1B TLR2 TLR9
36 infective endocarditis 30.1 CRP IL6 TLR2 TNF
37 pericarditis 30.1 ADA CRP IL1B IL6 IRAK4 TNF
38 mycobacterium fortuitum 30.1 CXCL8 LACTB
39 exanthem 30.1 CRP IL6 NLRP3 TLR9 TNF
40 genital herpes 30.0 IL10 TLR2 TLR9
41 brucellosis 30.0 CRP CXCL8 IL10 IL6 TNF
42 otitis media 29.9 ALB CXCL8 IL10 IL1B IL6 LACTB
43 toxoplasmosis 29.9 IL10 IL1B IL6 TLR2 TLR9 TNF
44 myeloma, multiple 29.9 ALB CRP CXCL8 IL6 TLR9 TNF
45 multiple sclerosis 29.9 CCL4 IL10 IL1B IL6 MMP9 PTGDS
46 temporal arteritis 29.9 CRP IL6 TNF
47 cystitis 29.9 CRP CXCL8 IL6 TNF
48 bacterial sepsis 29.9 CRP CXCL8 IL10 TNF
49 familial mediterranean fever 29.9 CRP IL1B NLRP3 TNF
50 colitis 29.9 CXCL8 IL10 IL1B IL6 TLR9 TNF

Comorbidity relations with Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis Chronic Meningitis
Deficiency Anemia Hypertension, Essential

Graphical network of the top 20 diseases related to Meningitis:



Diseases related to Meningitis
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Symptoms & Phenotypes for Meningitis

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UMLS symptoms related to Meningitis:


seizures, tremor, fever, pruritus, back pain, pain, headache, hemiplegia, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness, meningism, hyperexplexia

MGI Mouse Phenotypes related to Meningitis:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.34 ADA ALB CFP CRP IL10 IL1B
2 immune system MP:0005387 10.28 ADA CFP CRP IL10 IL1B IL6
3 hematopoietic system MP:0005397 10.27 ADA IL10 IL1B IL6 IRAK4 LYZ
4 cellular MP:0005384 10.24 ADA ALB IL10 IL6 IRAK4 LYZ
5 cardiovascular system MP:0005385 10.21 ADA CFP CRP IL10 IL1B IL6
6 digestive/alimentary MP:0005381 10.18 ADA ALB IL10 IL6 LYZ MMP9
7 mortality/aging MP:0010768 10.07 ADA ALB CFP IL10 IL1B IL6
8 integument MP:0010771 10.02 IL10 IL1B IL6 LYZ MMP9 NLRP3
9 liver/biliary system MP:0005370 9.92 ADA ALB IL10 IL6 LYZ NLRP3
10 neoplasm MP:0002006 9.81 ALB IL10 IL1B IL6 LYZ MMP9
11 renal/urinary system MP:0005367 9.61 ADA ALB IL6 LYZ MBL2 MMP9
12 skeleton MP:0005390 9.36 ADA CFP IL10 IL1B IL6 LYZ
Sources

Drugs & Therapeutics for Meningitis

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Drugs for Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 426)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
2
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1397-89-3 5280965 14956
3
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 22916-47-8 4189
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-02-2 5743
5
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 1177-87-3
6
Lamivudine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 134678-17-4 60825
7
Zidovudine Approved Phase 4,Not Applicable 30516-87-1 35370
8
Efavirenz Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 154598-52-4 64139
9
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 147-94-4 6253
10
Methotrexate Approved Phase 4,Phase 2 59-05-2, 1959-05-2 126941
11
Fluconazole Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 86386-73-4 3365
12
Ciprofloxacin Approved, Investigational Phase 4,Early Phase 1,Not Applicable 85721-33-1 2764
13
Ceftriaxone Approved Phase 4,Phase 3,Phase 1,Not Applicable 73384-59-5 5479530 5361919
14
Cefoxitin Approved Phase 4,Phase 2 35607-66-0 441199
15
Acetaminophen Approved Phase 4,Phase 3,Not Applicable 103-90-2 1983
16
Cefotaxime Approved Phase 4,Phase 2 63527-52-6 456256 5742673
17
Stavudine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 3056-17-5 18283
18
leucovorin Approved Phase 4,Phase 3,Phase 2 58-05-9 6006 143
19
Azathioprine Approved Phase 4 446-86-6 2265
20
Tetracycline Approved, Vet_approved Phase 4,Phase 3 60-54-8 5353990
21
Cosyntropin Approved Phase 4 16960-16-0 16129617
22
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
23
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
24
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
25
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613
26
Isoniazid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 54-85-3 3767
27
Nevirapine Approved Phase 4,Phase 2,Phase 3,Not Applicable 129618-40-2 4463
28
Ampicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 69-53-4 6249
29
Amikacin Approved, Investigational, Vet_approved Phase 4 37517-28-5 37768
30
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 59-30-3 6037
31
Glycine Approved, Nutraceutical, Vet_approved Phase 4 56-40-6 750
32
Lactitol Investigational Phase 4,Phase 2,Phase 3 585-86-4 3871
33
BCG vaccine Investigational Phase 4,Phase 2
34
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
35 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
36 Diuretics, Potassium Sparing Phase 4,Not Applicable
37 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
38 Sodium Channel Blockers Phase 4,Not Applicable
39 Anticonvulsants Phase 4
40 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
41 Liposomal amphotericin B Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Antifungal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
45 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
46 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
48 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1
49 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
50 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 566)
# Name Status NCT ID Phase Drugs
1 Study on the Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. Unknown status NCT01478035 Phase 4 Phenytoin;placebo
2 Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis Unknown status NCT02686853 Phase 4 Liposomal amphotericin B
3 The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Unknown status NCT02588196 Phase 4 Dexamethasone acetate
4 Kinetic of Immune Memory Response After Re-Vaccination With Meningococcal Vaccine Unknown status NCT00262015 Phase 4
5 Duration of Antibiotic Therapy in Community - Acquired Pneumonia Unknown status NCT01492387 Phase 4
6 Ciprofloxacin for the Prevention of Meningococcal Meningitis Completed NCT02724046 Phase 4 Ciprofloxacin
7 Infant Severe Sepsis and Bacterial Meningitis in Malawi Completed NCT01247909 Phase 4 Ceftriaxone v penicillin and gentamicin
8 Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis Completed NCT01540838 Phase 4 Infusion with paracetamol;Bolus without paracetamol
9 Optimal Time to Start Antiretroviral Therapy in HIV-infected Adults With Cryptococcal Meningitis Completed NCT00976040 Phase 4
10 Cryptococcal Optimal ART Timing Trial Completed NCT01075152 Phase 4 efavirenz
11 Pharmacological Study of High Doses of Ceftriaxone in Meningitidis Completed NCT01745679 Phase 4 Ceftriaxone treatment
12 Understanding the Immune Response to Two Different Meningitis Vaccines Completed NCT01593514 Phase 4
13 DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor Completed NCT00029523 Phase 4 Intrathecal (injected into the spinal fluid) DepoCyt;Intrathecal methotrexate;Intrathecal cytarabine (also known as ara-C)
14 Pertussis and Meningitis C Concomitant Vaccination in Adolescents Completed NCT02526394 Phase 4 Pertussis containing vaccine
15 Study on the Impact of Vaccination With a Conjugate Vaccine on Meningococcal Carriage Completed NCT01119482 Phase 4
16 A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents Completed NCT01424644 Phase 4
17 Post-Marketing Safety Study of Menactra® in Healthy Children, Adolescents, and Adults in the Philippines Completed NCT01270503 Phase 4
18 Investigating the Immune Response to 4CMenB in Infants Completed NCT02080559 Phase 4
19 Safety and Immunogenicity of Intradermal Versus Subcutaneous Doses of Menomune® Completed NCT00850603 Phase 4
20 Persistence of Bactericidal Antibodies in Adults Who Received a Booster Dose of Menactra® Approximately 4 Years Earlier Completed NCT02633787 Phase 4
21 Effect of Meningococcal Conjugate Vaccine on Meningococcal Carriage Completed NCT00119080 Phase 4
22 Study of Sanofi Pasteur and Lanzhou Institute's Meningococcal (Group A and C) Polysaccharide Vaccine in Children Completed NCT01430611 Phase 4
23 Immunogenicity and Safety of Two-Dose Series of Menactra® in Japanese Healthy Adult Subjects Completed NCT02591290 Phase 4
24 Operational Research for Cryptococcal Antigen Screening Completed NCT01535469 Phase 4 Fluconazole
25 Fractional Dose Tetravalent A, C, Y, W135 Meningococcal Polysaccharide Vaccine Completed NCT00271479 Phase 4
26 Immune Response to Rotavirus Vaccine After a Supplemental Dose Given at 9 Months of Age With Local EPI Vaccines in Mali Completed NCT02286895 Phase 4
27 Persistence of Immunogenicity of MenACWY Conjugate Vaccine 5 Years After Childhood Vaccination, and Immune Response to a Booster Dose Completed NCT01823536 Phase 4
28 A Phase IV Study to Evaluate the Immunogenicity and Safety in UK Laboratory Workers of Menitorix Completed NCT00503165 Phase 4
29 Immunogenicity of 7-Valent Pneumococcal Conjugate Vaccine in Lung Fluid of Adults With and Without HIV Infection Completed NCT00371878 Phase 4
30 Study of Menactra® in US Adolescents When Administered Concomitantly With Tdap Vaccine Completed NCT00777257 Phase 4
31 Study of Evaluating Safety and Immunogenicity of 23-Valent Pneumococcal Polysaccharide Vaccine With Influenza Vaccine in Children and Adults Completed NCT02062281 Phase 4
32 Study of Menactra® in Healthy Subjects at 9 Months and Concomitantly With Pentacel® at 15 to 18 Months of Age Completed NCT01659996 Phase 4
33 Immunogenicity of 13-valent Pneumococcal Conjugate Vaccine Compared to the Pneumococcal Polysaccharide Vaccine in Adult Kidney and Liver Transplant Patients Completed NCT01781871 Phase 4
34 Pneumococcal Vaccination of Crohn Patients Completed NCT01947010 Phase 4
35 Protection Against Pneumococcal Infection in Children With T1DM Completed NCT01939522 Phase 4
36 The Effect of Live Attenuated Inactivated Influenza Vaccine on Experimental Human Pneumococcal Carriage Study Completed NCT03502291 Phase 4
37 Induction of Immunity Against Streptococcus Pneumoniae in Adults With Inflammatory Bowel Disease Completed NCT01908283 Phase 4
38 A Study of the Interaction Between BCG And MenC Immunisation: BAM Completed NCT02002156 Phase 4
39 A Trial Comparing Two Pertussis-containing Vaccines in Pregnancy and Vaccine Responses in UK Mothers and Their Infants Completed NCT02145624 Phase 4 Repevax;Boostrix-IPV
40 Immunogenicity of 3+1 Versus 2+1 Schedule for PCV7 Completed NCT02040402 Phase 4
41 Cosyntropin Versus Epidural Blood Patch (EBP) for Treatment of Treatment of Post Dural Puncture Headache Completed NCT02394457 Phase 4 Cosyntropin
42 Study Evaluating the Safety and Ability to Produce Immune Response of Prevenar and Meningitec Given at the Same Time Completed NCT00581035 Phase 4
43 Safety and Efficacy Study of Flebogamma 5% DIF IGIV in Pediatric Subjects Completed NCT00634569 Phase 4
44 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Completed NCT03226119 Phase 4
45 Evaluation of Meningococcal C Vaccine Programmes in Canadian Children Completed NCT00936962 Phase 4
46 Determination of Gentamicin Dosing in Neonatal Patients Completed NCT00198601 Phase 4 Gentamicin in Uniject Pre-filled syringe
47 Persistence of Antibody Response to N. Meningitidis Group C in Children Completed NCT00316654 Phase 4
48 Kinetics of B Cell Response in Infants Menjugate Vaccination Completed NCT00310700 Phase 4
49 Persistence of Immune Response After Vaccination With MCC Completed NCT00310687 Phase 4
50 Persistence of Antibodies and Kinetics of B Cell Response in Healthy Children After Vaccination With MCC Vaccine Completed NCT00310713 Phase 4

Search NIH Clinical Center for Meningitis

Cochrane evidence based reviews: meningitis

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Genetic Tests for Meningitis

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Genetic tests related to Meningitis:

# Genetic test Affiliating Genes
1 Meningitis 29
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Anatomical Context for Meningitis

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MalaCards organs/tissues related to Meningitis:

41
Brain, Spinal Cord, Testes, Pituitary, T Cells, Colon, Liver
Sources

Publications for Meningitis

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Articles related to Meningitis:

(show top 50) (show all 8555)
# Title Authors Year
1
Epidemiology of Meningitis and Encephalitis in Infants and Children in the United States, 2011-2014. ( 30531527 )
2019
2
A qualitative exploration of facilitators and barriers to meningitis vaccination uptake among men who have sex with men. ( 30505652 )
2019
3
Utility of OTOPLAN Reconstructed Images for Surgical Planning of Cochlear Implantation in a Case of Post-meningitis Ossification. ( 30531645 )
2019
4
Global shortages of BCG vaccine and tuberculous meningitis in children. ( 30554756 )
2019
5
Cryptococcal meningitis in a daily cannabis smoker without evidence of immunodeficiency. ( 29374632 )
2018
6
A study on correlations of procalcitonin and interleukin-6 with viral meningitis. ( 29917201 )
2018
7
Draft Genome Sequences of Five Neonatal Meningitis-Causing Escherichia coli Isolates (SP-4, SP-5, SP-13, SP-46, and SP-65). ( 29674529 )
2018
8
Pulmonary alveolar proteinosis following cryptococcal meningitis: a possible cause? ( 29592982 )
2018
9
A refugee patient with meningococcal meningitis type B. ( 29757696 )
2018
10
Novel Treatment of Cryptococcal Meningitis via NeurapheresisTM Therapy. ( 29788431 )
2018
11
A Rare Case of<i>Sphingomonas paucimobilis</i>Meningitis in the Absence of Cerebrospinal Fluid Pleocytosis. ( 29435467 )
2018
12
The first report of human meningitis and pyogenic ventriculitis caused by Streptococcus suis: A case report. ( 29429850 )
2018
13
Cerebral tryptophan metabolism and outcome of tuberculous meningitis: an observational cohort study. ( 29395996 )
2018
14
Arachnoid diverticulum diagnosis following treatment of cryptococcal meningitis in a dog. ( 29636913 )
2018
15
Paradoxical Reaction in a Patient with Co-Occurring Tuberculous Meningitis and Pott's Disease. ( 29907737 )
2018
16
Tigecycline in the treatment of multidrug-resistant Acinetobacter baumannii meningitis: Results of the Ege study. ( 29960893 )
2018
17
Scrub Typhus Meningitis Versus Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396931 )
2018
18
The first case report of Enterococcus gallinarum meningitis in neonate: A literature review. ( 29443752 )
2018
19
Utility of magnetic resonance cisternography with intrathecal gadolinium in detection of cerebrospinal fluid fistula associated with Mondini dysplasia in a patient with recurrent meningitis: Case report and literature review. ( 29770252 )
2018
20
Duplex recombinase polymerase amplification assays incorporating competitive internal controls for bacterial meningitis detection. ( 29378166 )
2018
21
Cerebrospinal Fluid Lactate as a Prognostic Indicator in Postneurosurgical Bacterial Meningitis and Use of Intrathecal Colistin. ( 29743769 )
2018
22
Diagnosis of tuberculous meningitis with invasive pulmonary sampling. ( 29303733 )
2018
23
Antiphospholipid Syndrome Complicating Pneumococcal Meningitis. ( 29845960 )
2018
24
Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing. ( 29710329 )
2018
25
Delayed Cerebral Injury in Adults With Bacterial Meningitis: A Novel Complication of Adjunctive Steroids? ( 29746358 )
2018
26
A world without bacterial meningitis: how genomic epidemiology can inform vaccination strategy. ( 29636909 )
2018
27
Meningococcal meningitis with neurological complications and meningococcemia due to serogroup W sequence type 11 complex. ( 29373268 )
2018
28
Acral-accentuated exanthem in an infant with parechovirus meningitis. ( 29205494 )
2018
29
Adult-Onset Recurrent Bacterial Meningitis: Immunological Red Herrings. ( 29401276 )
2018
30
Development of a clinical prediction rule for tuberculous meningitis in adults in Lima, Peru. ( 29446860 )
2018
31
Neonatal meningitis and recurrent bacteremia with group B Streptococcus transmitted by own mother's milk: A case report and review of previous cases. ( 29959094 )
2018
32
Acute streptococcal meningitis presenting as bilateral conductive hearing loss. ( 29655501 )
2018
33
A Child With Intermittent Headaches and Eosinophilic Meningitis. ( 29438532 )
2018
34
Cystic Encephalomalacia following Vasculopathy and Vasospasm of Proximal Intracranial Arteries Due to Pneumococcal Meningitis in a Infant. ( 29523004 )
2018
35
Using Predictive Model for Screening Bacterial Meningitis in National Surveillance System in Iran. ( 29968622 )
2018
36
Invasive Pomacea snails as important intermediate hosts of Angiostrongylus cantonensis in Laos, Cambodia and Vietnam: Implications for outbreaks of eosinophilic meningitis. ( 29574000 )
2018
37
Cryptococcal meningitis: an unusual presentation of primary HIV infection. ( 29966507 )
2018
38
Community acquired <i>Klebsiella pneumoniae</i> meningitis: a case report. ( 29951382 )
2018
39
Cerebrospinal fluid monocytes in bacterial meningitis, viral meningitis, and neuroborreliosis. ( 29628177 )
2018
40
Adjuvant non-bacteriolytic and anti-inflammatory combination therapy in pneumococcal meningitis: an investigation in a mouse model. ( 29649601 )
2018
41
The novel fungal CYP51 inhibitor VT-1598 is efficacious alone and in combination with liposomal amphotericin B in a murine model of cryptococcal meningitis. ( 29947783 )
2018
42
Listeria Meningitis during Infliximab-based Treatment for Ulcerative Colitis. ( 29607962 )
2018
43
Miliary Tuberculosis Presenting With Meningitis in a Patient Treated With Mycophenolate for Lupus Nephritis: Challenges in Diagnosis and Review of the Literature. ( 29707591 )
2018
44
Diagnosis of Meningitis Caused by Pathogenic Microorganisms Using Magnetic Resonance Imaging: A Systematic Review. ( 29967667 )
2018
45
Detection of Bacterial Meningitis Pathogens by PCR-Mass Spectrometry in Cerebrospinal Fluid. ( 29945321 )
2018
46
<i>Burkholderia multivorans:</i> A rare yet emerging cause of bacterial meningitis. ( 29619322 )
2018
47
A Fatal Case of Undiagnosed Candida Meningitis: Role of Computer-assisted Diagnosis. ( 29953039 )
2018
48
Use of Linezolid in a Child With Tuberculous Meningitis. ( 29652742 )
2018
49
Meningoencephalocele causing recurrent meningitis. ( 29744093 )
2018
50
Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States. ( 29244019 )
2018
Sources

Variations for Meningitis

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Expression for Meningitis

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Search GEO for disease gene expression data for Meningitis.
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Pathways for Meningitis

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Pathways related to Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14.06 CCL4 CFP CRP CXCL1 CXCL8 IL10
2
Akt Signaling 64
Show member pathways
 13.51 CCL4 CXCL1 CXCL8 IL10 IL1B IL6
3
Cytokine Signaling in Immune system 66
Show member pathways
 13.44 CCL4 CXCL1 CXCL8 IL10 IL1B IL6
4
PAK Pathway 64
Show member pathways
 13.33 CCL4 CXCL1 CXCL8 IL10 IL1B IL6
5
Human cytomegalovirus infection 37
Show member pathways
 13.15 CCL4 CXCL1 CXCL8 IL1B IL6 IRAK4
6
Influenza A 37
Show member pathways
 12.84 CFP CXCL8 IL1B IL6 IRAK4 NLRP3
7
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.79 CCL4 CXCL8 IL1B IL6 TNF
8
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.79 CCL4 CXCL1 CXCL8 IL10 IL1B IL6
9
NF-KappaB Family Pathway 64
Show member pathways
 12.78 IL1B IL6 IRAK4 TLR2 TLR9 TNF
10
NF-kappaB Signaling 4
12.66 IL10 IL1B IRAK4 TLR2 TLR9 TNF
11
TRAF Pathway 64
Show member pathways
 12.65 IL1B IRAK4 TLR2 TLR9 TNF
12
Th17 cell differentiation 37
Show member pathways
 12.65 IL10 IL1B IL6 TLR2 TNF
13
Immune response IL-23 signaling pathway 22
Show member pathways
 12.64 CXCL1 IL10 IL1B IL6 TNF
14
T cell receptor signaling pathway 37
Show member pathways
 12.44 IL10 IL1B IL6 TNF
15
IL-17 Family Signaling Pathways 65
Show member pathways
 12.43 CXCL1 CXCL8 IL1B IL6 MMP9 TLR2
16
Selenium Micronutrient Network 1
Show member pathways
 12.42 ALB CRP IL1B IL6 TNF
17
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.4 CXCL8 IL6 IRAK4 TLR2 TLR9 TNF
18
Toll Comparative Pathway 64
Show member pathways
 12.39 CXCL8 IL1B IL6 IRAK4 TNF
19
Toxoplasmosis 37
Show member pathways
 12.35 IL10 IL1B IRAK4 TLR2 TNF
20
IL-1 Family Signaling Pathways 65
Show member pathways
 12.35 CXCL8 IL1B IL6 IRAK4 TLR2 TNF
21
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 12.34 CCL4 CXCL1 CXCL8 IL1B IRAK4 MMP9
22
C-type lectin receptor signaling pathway 37
Show member pathways
 12.34 IL10 IL1B IL6 NLRP3 TLR9 TNF
23
Epstein-Barr virus infection 37
12.33 IL6 IRAK4 TLR2 TNF
24
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.32 CXCL8 IL10 IL1B IL6 TNF
25
Tuberculosis 37
12.31 IL10 IL1B IL6 IRAK4 TLR2 TLR9
26
Colorectal Cancer Metastasis 64
12.29 IL6 MMP9 TLR2 TLR9 TNF
27
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.29 CXCL8 IL10 IL1B IL6 TNF
28
Bacterial infections in CF airways 22
Show member pathways
 12.24 CXCL8 IL1B IL6 IRAK4 TLR2 TLR9
29
Th1 Differentiation Pathway 65
Show member pathways
 12.18 IL10 IL1B IL6 TLR2 TLR9 TNF
30
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 12.16 IL1B IL6 MMP9 TLR2 TNF
31
Spinal Cord Injury 1
12.14 CXCL1 CXCL8 IL1B IL6 MMP9 TNF
32
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.13 CCL4 CXCL8 IL10 IL1B IL6
33
Interleukin-4 and 13 signaling 66
12.11 CXCL8 IL10 IL1B IL6 MMP9 TNF
34
TNF signaling pathway 37
12.1 CXCL1 IL1B IL6 MMP9 TNF
35
NF-kappa B signaling pathway 37
12.03 CCL4 CXCL8 IL1B IRAK4 TNF
36
Senescence and Autophagy in Cancer 1
12.02 CXCL1 CXCL8 IL1B IL6
37
AGE-RAGE signaling pathway in diabetic complications 37
11.99 CXCL8 IL1B IL6 TNF
38
Salmonella infection (KEGG) 37
11.98 CCL4 CXCL1 CXCL8 IL1B IL6
39
Rheumatoid arthritis 37
11.96 CXCL1 CXCL8 IL1B IL6 TLR2 TNF
40
Amoebiasis 37
11.89 CXCL1 CXCL8 IL10 IL1B IL6 TLR2
41
Dendritic Cells Developmental Lineage Pathway 65
11.88 IL10 IL1B IL6 TLR9 TNF
42
Innate Lymphoid Cell Differentiation Pathways 65
11.81 IL10 IL1B TNF
43
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.8 CXCL8 IL1B IL6 MMP9 TNF
44
Pertussis 37
11.75 CXCL8 IL10 IL1B IL6 IRAK4 NLRP3
45
LPA receptor mediated events 1
11.72 CXCL8 IL6 MMP9
46
Lung fibrosis 1
11.71 CCL4 CXCL8 IL1B IL6 MMP9 TNF
47
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.65 CCL4 CXCL1 IL10 IL1B IL6 MMP9
48
Legionellosis 37
11.62 CXCL1 CXCL8 IL1B IL6 TLR2 TNF
49
amb2 Integrin signaling 1
11.58 IL6 MMP9 TNF
50
MSP-RON Signaling 64
11.57 IL1B TLR2 TNF
Sources

GO Terms for Meningitis

About this section

Cellular components related to Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 ALB CCL4 CFP CRP CXCL1 CXCL8
2 extracellular space GO:0005615 9.53 ADA ALB CCL4 CFP CRP CXCL1
3 tertiary granule lumen GO:1904724 9.46 CFP CXCL1 LYZ MMP9
4 specific granule lumen GO:0035580 9.43 CFP CXCL1 LYZ

Biological processes related to Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.99 CFP IL10 LYZ MBL2 TLR9 TNF
2 defense response GO:0006952 9.98 CXCL1 CXCL8 NLRP3 TNF
3 immune response GO:0006955 9.96 CCL4 CFP CXCL1 CXCL8 IL10 IL1B
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.94 IL10 IL1B IL6 TNF
5 defense response to Gram-negative bacterium GO:0050829 9.91 IL6 LYZ TLR9
6 positive regulation of JNK cascade GO:0046330 9.91 IL1B TLR9 TNF
7 positive regulation of inflammatory response GO:0050729 9.91 TLR2 TLR9 TNF
8 neutrophil chemotaxis GO:0030593 9.91 CCL4 CXCL1 CXCL8 IL1B
9 cellular response to lipopolysaccharide GO:0071222 9.91 CXCL1 CXCL8 IL10 IL1B IL6 NLRP3
10 chemokine-mediated signaling pathway GO:0070098 9.9 CCL4 CXCL1 CXCL8
11 positive regulation of smooth muscle cell proliferation GO:0048661 9.89 IL6 IRAK4 TNF
12 response to glucocorticoid GO:0051384 9.88 IL10 IL1B IL6 TNF
13 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.87 IL10 MMP9 TNF
14 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.87 IL1B IL6 IRAK4 NLRP3 TLR2 TLR9
15 positive regulation of JUN kinase activity GO:0043507 9.85 IL1B TLR9 TNF
16 positive regulation of phagocytosis GO:0050766 9.85 IL1B MBL2 TNF
17 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 IL1B TLR2 TLR9 TNF
18 toll-like receptor signaling pathway GO:0002224 9.84 IRAK4 TLR2 TLR9
19 acute-phase response GO:0006953 9.84 CRP IL6 MBL2
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.83 IL1B TLR2 TNF
21 positive regulation of interleukin-6 production GO:0032755 9.83 IL1B IL6 TLR2 TLR9 TNF
22 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.82 IRAK4 TLR2 TLR9
23 negative regulation of interleukin-6 production GO:0032715 9.81 IL10 TLR9 TNF
24 negative regulation of neurogenesis GO:0050768 9.8 IL1B IL6 TNF
25 leukocyte chemotaxis GO:0030595 9.8 CXCL1 CXCL8 IL10
26 positive regulation of interleukin-8 production GO:0032757 9.78 IL1B TLR2 TLR9 TNF
27 embryonic digestive tract development GO:0048566 9.77 ADA CXCL8 TNF
28 positive regulation of glial cell proliferation GO:0060252 9.77 IL1B IL6 TNF
29 positive regulation of chemokine production GO:0032722 9.76 IL6 TLR2 TLR9 TNF
30 negative regulation of growth of symbiont in host GO:0044130 9.75 IL10 MBL2 TNF
31 regulation of cytokine secretion GO:0050707 9.74 TLR2 TLR9
32 I-kappaB phosphorylation GO:0007252 9.74 TLR2 TLR9
33 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.74 IL10 IL1B TNF
34 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.73 IL1B TLR9
35 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.73 TLR9 TNF
36 opsonization GO:0008228 9.72 CRP MBL2
37 endothelial cell apoptotic process GO:0072577 9.72 IL10 TNF
38 neutrophil mediated immunity GO:0002446 9.72 IL6 IRAK4
39 positive regulation of chemokine biosynthetic process GO:0045080 9.72 IL1B TNF
40 negative regulation of interleukin-8 production GO:0032717 9.71 IL10 TLR9
41 regulation of establishment of endothelial barrier GO:1903140 9.71 IL1B TNF
42 negative regulation of cytokine secretion involved in immune response GO:0002740 9.71 IL10 TNF
43 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.71 IL6 NLRP3
44 negative regulation of lipid storage GO:0010888 9.71 CRP IL6 TNF
45 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 IL10 TLR2 TLR9
46 regulation of circadian sleep/wake cycle, sleep GO:0045187 9.7 ADA PTGDS
47 interleukin-1 beta production GO:0032611 9.7 IL1B