Meningitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MNN013 MIFTS: 66	Meningitis Categories: Infectious diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

Sources

Aliases & Classifications for Meningitis

MalaCards integrated aliases for Meningitis:

Name: Meningitis ¹¹ ⁷⁵ ⁵³ ⁴¹ ² ⁴³ ¹⁴ ⁷¹

Fungal Meningitis Due to Cryptococcus Neoformans ³³

Cryptococcal Meningoencephalitis ³³

Meningitis Due to H. Influenzae ³³

Acute Streptococcal Meningitis ³³

Meningitis Due to Cryptococcus ³³

Staphylococcal Meningitis ³³

Cryptococcosis Meningitis ³³

Streptococcal Meningitis ³³

Cryptococcal Meningitis ³³

Cryptococcus Meningitis ³³

Mumps Virus Meningitis ³³

Adenoviral Meningitis ³³

Influenzal Meningitis ³³

Influenza Meningitis ³³

Mumps Meningitis ³³

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Diseases of the nervous system

Inflammatory diseases of the central nervous system

Meningitis due to other and unspecified causes

Meningitis due to other specified causes

Meningitis, unspecified

External Ids:

Disease Ontology ¹¹ DOID:9471

ICD9CM ³⁴ 322.9

MeSH ⁴³ D008581

NCIt ⁴⁹ C26828

SNOMED-CT ⁶⁸ 154983000

ICD10 ³¹ G03 G03.8 G03.9

ICD11 ³³ 1005770900 1331660907 1727868245 more

UMLS ⁷¹ C0025289

Sources

Summaries for Meningitis

MedlinePlus: ⁴¹ Meningitis is inflammation of the thin tissue that surrounds the brain and spinal cord, called the meninges. There are several types of meningitis. The most common is viral meningitis. You get it when a virus enters the body through the nose or mouth and travels to the brain. Bacterial meningitis is rare, but can be deadly. It usually starts with bacteria that cause a cold-like infection. It can cause stroke, hearing loss, and brain damage. It can also harm other organs. Pneumococcal infections and meningococcal infections are the most common causes of bacterial meningitis. Anyone can get meningitis, but it is more common in people with weak immune systems. Meningitis can get serious very quickly. You should get medical care right away if you have: A sudden high fever A severe headache A stiff neck Nausea or vomiting Early treatment can help prevent serious problems, including death. Tests to diagnose meningitis include blood tests, imaging tests, and a spinal tap to test cerebrospinal fluid. Antibiotics can treat bacterial meningitis. Antiviral medicines may help some types of viral meningitis. Other medicines can help treat symptoms. There are vaccines to prevent some of the bacterial infections that cause meningitis. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary: Meningitis, also known as fungal meningitis due to cryptococcus neoformans, is related to meningococcal meningitis and tuberculous meningitis, and has symptoms including tremor, fever and back pain. An important gene associated with Meningitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are ERK Signaling and Innate Immune System. The drugs Phenytoin and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone marrow, and related phenotypes are homeostasis/metabolism and cardiovascular system

CDC: ² Meningitis is an inflammation (swelling) of the protective membranes covering the brain and spinal cord. A bacterial or viral infection of the fluid surrounding the brain and spinal cord usually causes the swelling. However, injuries, cancer, certain drugs, and other types of infections also can cause meningitis. It is important to know the specific cause of meningitis because the treatment differs depending on the cause.

Disease Ontology: ¹¹ A central nervous system disease that is characterized by an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells.

Wikipedia: ⁷⁵ Meningitis is acute or chronic inflammation of the protective membranes covering the brain and spinal... more...

Sources

Related Diseases for Meningitis

Diseases in the Meningitis family:

Viral Meningitis	Chronic Meningitis
Bacterial Meningitis

Diseases related to Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2054)

#	Related Disease	Score	Top Affiliating Genes
1	meningococcal meningitis	33.4	TLR2 MBL2 CFP
2	tuberculous meningitis	33.4	LYZ ADA
3	aseptic meningitis	33.2	TNF IL6 IL1B IL10 CXCL8 CRP
4	viral meningitis	33.1	TNF IL6 IFNG CXCL8 CRP CCL2
5	fungal meningitis	33.1	TNF IL6 IL10 IFNG CRP ALB
6	cryptococcal meningitis	33.0	TNF IL6 IL10 IFNG ALB ADA
7	lymphocytic choriomeningitis	32.9	TLR2 IL6 CXCL8
8	bacterial meningitis	32.7	TNF TLR2 LYZ LACTB IL1B IL10
9	chronic meningitis	32.7	IL1B CRP ALB
10	listeriosis	32.4	TNF TLR2 MBL2 IL6 IL1B IL10
11	meningoencephalitis	32.4	TNF IL6 IL1B IL10 CRP ALB
12	haemophilus influenzae	32.4	TNF TLR2 LACTB IL1B CXCL8
13	meningococcal infection	32.4	TLR2 MBL2 LACTB CFP CD46
14	cryptococcosis	32.3	TNF MBL2 IL10 IFNG
15	vogt-koyanagi-harada disease	32.2	TNF IL6 IL10
16	viral encephalitis	32.1	TNF IL6 IL1B IL10 CCL2
17	cysticercosis	32.1	IL6 IL1B IL10
18	neurosyphilis	32.1	TLR2 IL10 CXCL8
19	leptospirosis	32.1	TNF TLR2 IL6 IL1B IL10 IFNG
20	bacteremia 2	32.0	MBL2 LACTB CRP
21	spinal cord disease	32.0	TNF IL6 IL10 ALB
22	mannose-binding lectin deficiency	32.0	MBL2 IL6
23	tuberculous peritonitis	31.9	IFNG CRP ALB ADA
24	cerebral palsy	31.8	TNF MBL2 IL6 IL1B IL10 CXCL8
25	encephalitis	31.8	TNF TLR2 IL6 IL1B IL10 CXCL8
26	arachnoiditis	31.8	TNF IL1B IFNG CRP
27	behcet syndrome	31.8	TNF TLR2 MBL2 IL6 IL1B IL10
28	extrapulmonary tuberculosis	31.8	TNF TLR2 IL6 IL1B IL10 IFNG
29	herpes zoster	31.7	TLR2 IL10 IFNG
30	intracranial hypertension	31.7	TNF IL6 IL1B CRP ALB
31	west nile encephalitis	31.6	TNF IL6 IL1B IL10 IFNG CRP
32	acquired immunodeficiency syndrome	31.6	TNF IL6 IL1B IL10 IFNG CRP
33	human immunodeficiency virus type 1	31.6	IL10 IFNG CXCL1 CCL4 CCL2
34	headache	31.6	TNF CXCL8 ALB
35	myelitis	31.5	TNF IL6 IL10 CXCL8
36	exanthem	31.5	TNF IL6 IL1B IL10 IFNG CXCL8
37	mumps	31.5	TNF IL6 IL1B IL10 IFNG CXCL8
38	pleural empyema	31.5	IL6 CRP ALB ADA
39	chickenpox	31.5	TNF IL6 IL1B IL10 IFNG CRP
40	miliary tuberculosis	31.5	TNF IL10 IFNG CRP ALB ADA
41	vasculitis	31.5	TNF MBL2 IL6 IL1B IL10 CXCL8
42	toxic shock syndrome	31.5	TNF TLR2 IL6 IL1B IL10 IFNG
43	labyrinthitis	31.4	TNF IL1B CRP
44	bell's palsy	31.4	TNF IL6 CRP ALB
45	stroke, ischemic	31.4	TNF IL6 IL1B CXCL1 CRP ALB
46	cranial nerve palsy	31.4	TNF CRP ALB
47	papilledema	31.4	IL6 CRP ALB
48	inappropriate adh syndrome	31.4	IL6 CRP ALB
49	poliomyelitis	31.4	TNF IL6 IL10 IFNG ALB
50	intracranial abscess	31.3	LACTB CRP

Comorbidity relations with Meningitis via Phenotypic Disease Network (PDN):

Acute Cystitis	Chronic Meningitis
Deficiency Anemia	Hypertension, Essential

Graphical network of the top 20 diseases related to Meningitis:

Sources

Symptoms & Phenotypes for Meningitis

UMLS symptoms related to Meningitis:

tremor; fever; back pain; headache; pruritus; syncope; hemiplegia; pain; chronic pain; sciatica; seizures; vertigo/dizziness; sleeplessness; meningism; hyperexplexia

GenomeRNAi Phenotypes related to Meningitis according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.17	ADA ALB CCL2 CCL4 CD46 CFI
2	no effect	GR00402-S-2	10.17	ADA ALB CCL2 CCL4 CD46 CFI

MGI Mouse Phenotypes related to Meningitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.3	ADA ALB CCL2 CFI CFP CRP
2	cardiovascular system	MP:0005385	10.13	ADA ALB CCL2 CD46 CFP CRP
3	neoplasm	MP:0002006	10.11	ALB CCL2 IFNG IL10 IL1B IL6
4	muscle	MP:0005369	10.09	ADA ALB CCL2 IFNG IL10 IL6
5	liver/biliary system	MP:0005370	10.06	ADA ALB CCL2 IFNG IL10 IL6
6	immune system	MP:0005387	10.06	ADA ALB CCL2 CFI CFP CRP
7	digestive/alimentary	MP:0005381	9.97	ADA ALB CCL2 IFNG IL10 IL6
8	skeleton	MP:0005390	9.77	ADA CCL2 CFP CXCL1 IFNG IL10
9	hematopoietic system	MP:0005397	9.44	ADA CCL2 CFI CXCL1 IFNG IL10

Sources

Drugs & Therapeutics for Meningitis

Drugs for Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 271)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Phenytoin

Approved, Vet_approved

Phase 4

57-41-0

1775

Acetaminophen

Approved

Phase 4

103-90-2

1983

Cefotaxime

Approved

Phase 4

63527-52-6

5742673 456256

Lactitol

Approved, Investigational

Phase 4

585-86-4

157355

Ceftriaxone

Approved

Phase 4

73384-59-5

5479530

Lamivudine

Approved, Investigational

Phase 4

134678-17-4

60825

Stavudine

Approved, Investigational

Phase 4

3056-17-5

18283

Efavirenz

Approved, Investigational

Phase 4

154598-52-4

64139

Zidovudine

Approved

Phase 4

30516-87-1

35370

Levoleucovorin

Approved, Experimental, Investigational

Phase 4

68538-85-2, 58-05-9, 73951-54-9

149436 6006

Methotrexate

Approved

Phase 4

1959-05-2, 59-05-2

4112 126941

Dimercaprol

Approved

Phase 4

59-52-9

3080

Acyclovir

Approved

Phase 4

59277-89-3

2022

Valaciclovir

Approved, Investigational

Phase 4

124832-27-5, 124832-26-4

60773 135398742

Medroxyprogesterone acetate

Approved, Investigational

Phase 4

520-85-4, 71-58-9

6279 10631

Folic acid

Approved, Nutraceutical, Vet_approved

Phase 4

59-30-3

6037

HIV Protease Inhibitors

Phase 4

protease inhibitors

Phase 4

BB 1101

Phase 4

Immunologic Factors

Phase 4

Vaccines

Phase 4

beta-Lactams

Phase 4

Lactams

Phase 4

Heptavalent Pneumococcal Conjugate Vaccine

Phase 4

Gastrointestinal Agents

Phase 4

Anti-Retroviral Agents

Phase 4

Cathartics

Phase 4

Laxatives

Phase 4

Anti-HIV Agents

Phase 4

Reverse Transcriptase Inhibitors

Phase 4

Penicillins

Phase 4

Gentamicins

Phase 4

Folic Acid Antagonists

Phase 4

Folate

Phase 4

Vitamin B9

Phase 4

Vitamin B Complex

Phase 4

Dermatologic Agents

Phase 4

Immunoglobulins, Intravenous

Phase 4

Neuromuscular Blocking Agents

Phase 4

Aluminum hydroxide

Approved, Investigational

Phase 2, Phase 3

21645-51-2

Sertraline

Approved

Phase 3

79617-96-2

68617

Vancomycin

Approved

Phase 3

1404-90-6

14969

Hydroxocobalamin

Approved

Phase 2, Phase 3

13422-51-0

15589840 44475014

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 2, Phase 3

1177-87-3

3680

Dexamethasone

Approved, Investigational, Vet_approved

Phase 2, Phase 3

50-02-2

3003 5743

Glycerin

Approved, Investigational

Phase 3

56-81-5

753

Meticillin

Approved, Investigational

Phase 3

61-32-5

6087

Trimethoprim

Approved, Vet_approved

Phase 3

738-70-5

5578

Sulfamethoxazole

Approved

Phase 3

723-46-6

5329

Zinc cation

Approved, Experimental, Investigational

Phase 3

7440-66-6, 23713-49-7

32051

Interventional clinical trials:

(show top 50) (show all 359)

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis Without Acquired Immune Deficiency Syndrome	Unknown status	NCT02686853	Phase 4	Liposomal amphotericin B
2	Evaluation of Safety and Immunogenicity of Meningococcal B and Meningococcal ACWY Vaccine in at Risk Population (ProPositive Study)	Unknown status	NCT03682939	Phase 4
3	A Phase IV, Single Center, Open-Label, Controlled, Randomized Study to Evaluate the Memory Response of Children Previously Vaccinated With Chiron Meningococcal C Conjugate Vaccine, Menjugate® and Describe the Kinetic of the Antibody Response and Maturation on Days 2-7 and 28 After Challenge With Pasteur Merieux Meningococcal A/C Polysaccharide Vaccine or Menjugate®	Unknown status	NCT00262015	Phase 4
4	Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. A Multi-center Comparative Randomized Double-blind and Placebo-controlled Clinical Trial	Unknown status	NCT01478035	Phase 4	Phenytoin;placebo
5	The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis	Unknown status	NCT02588196	Phase 4	Dexamethasone acetate
6	Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis, Especially of Pneumococcal Meningitis, in Angola.	Completed	NCT01540838	Phase 4	Infusion with paracetamol;Bolus without paracetamol
7	Persistence of Bactericidal Antibodies in Adults Who Received a Booster Dose of Menactra® Approximately Four Years Earlier	Completed	NCT02633787	Phase 4
8	Immunogenicity and Safety of Two-Dose Series of a Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine (SP284; Menactra®) in Japanese Healthy Adult Subjects	Completed	NCT02591290	Phase 4
9	A Phase III/IV Randomised Open-label Study and Comparison of the Immunogenicity and Safety of a Single Adolescent Booster Dose of a Meningococcal Group C Conjugate-containing Booster Vaccine (Meningitec™, OR NeisVac-C™ , OR Menitorix™), When Given Concurrently With an Acellular Pertussis-containing Booster Vaccine (Repevax™ or IPV-Boostrix™)	Completed	NCT02526394	Phase 4	Pertussis containing vaccine
10	Postmarketing Surveillance Study for Use of Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine (Menactra®) in the Republic of Korea	Completed	NCT02864927	Phase 4
11	Cluster-randomized Trial to Evaluate the Impact of Ciprofloxacin for Contacts of Cases of Meningococcal Meningitis as an Epidemic Response	Completed	NCT02724046	Phase 4	Ciprofloxacin
12	Trial for the Optimal Timing of HIV Therapy After Cryptococcal Meningitis	Completed	NCT01075152	Phase 4	efavirenz
13	A Randomized Clinical Trial of Immediate Versus Standard Antiretroviral Therapy for HIV-infected Adults Presenting With Cryptococcal Meningitis	Completed	NCT00976040	Phase 4
14	Assay of the Immunogenicity of Fractional Dose Tetravalent A, C, Y, W135 Meningococcal Polysaccharide Vaccine in Africa	Completed	NCT00271479	Phase 4
15	A Phase IV Randomized, Observer-blind, Controlled Study to Demonstrate Non-inferior Immunogenicity of Yuxi Walvax MPV ACYW® Vaccine as Compared to Sanofi Pasteur Menactra® Vaccine in Healthy Subjects Aged 2-10 Years	Completed	NCT04450498	Phase 4
16	An Open Randomised Trial of Ceftriaxone v Penicillin and Gentamicin in Infant Severe Sepsis and Bacterial Meningitis in Malawi	Completed	NCT01247909	Phase 4	Ceftriaxone v penicillin and gentamicin
17	A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of a Combined Tetanus, Reduced Diphtheria Toxoid, Acellular Pertussis Vaccine (Tdap, Boostrix®) and Quadrivalent Human Papillomavirus [Types 6, 11, 16, 18] Recombinant Vaccine (Gardasil®) in Healthy Adolescents When Administered With MenACWY Conjugate Vaccine	Completed	NCT01424644	Phase 4
18	Operational Research for Cryptococcal Antigen Screening to Improve ART Survival	Completed	NCT01535469	Phase 4	Fluconazole
19	A Sourcing Study to Collect Human Biological (Serum) Samples From Healthy Adults	Completed	NCT03493919	Phase 4
20	A Randomized Clinical Study to Determine the Patient Benefit and Safety of Depocyt (Cytarabine Liposome Injection) for the Treatment of Neoplastic Meningitis	Completed	NCT00029523	Phase 4	Intrathecal (injected into the spinal fluid) DepoCyt;Intrathecal methotrexate;Intrathecal cytarabine (also known as ara-C)
21	Therapeutic Monitoring of Ceftriaxone, Prescribed at High Doses, in the Treatment of Meningitis and Others Neurological Infections.	Completed	NCT01745679	Phase 4	Ceftriaxone treatment
22	A Randomised, Descriptive, Open Label, Study Exploring the Relationship Between Gene Expression Signatures With Reactogenicity and Immunogenicity Following Vaccination With Serogroup B Meningococcal Vaccine (4CMenB)	Completed	NCT02080559	Phase 4
23	Immunogenicity and Safety of Meningococcal (Groups A, C, Y, and W-135) Diphtheria Toxoid Conjugate Vaccine (Menactra®) in Adolescents in the US When Administered Concomitantly With Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed (Tdap Vaccine)	Completed	NCT00777257	Phase 4
24	Safety and Immunogenicity of Intradermal, and Low-dose Subcutaneous vs Subcutaneous Administration of Menomune® - A/C/Y/W-135	Completed	NCT00850603	Phase 4
25	Open Label Study of Lung and Serum Immunoglobulin Responses to 7-Valent Pneumococcal Conjugate Vaccine in HIV Infected and Non-HIV Infected Malawian Adults	Completed	NCT00371878	Phase 4
26	An Immunogenicity and Safety Evaluation of Menactra® (Meningococcal [Groups A, C, Y and W-135] Polysaccharide Diphtheria Toxoid Conjugate Vaccine) When Administered to Healthy Subjects at 9 Months and Concomitantly With Pentacel® at 15 to 18 Months of Age.	Completed	NCT01659996	Phase 4
27	A Single Centre, Open-label, Randomised Clinical Study to Investigate Meningococcal Serogroup A and C Saccharide Specific B Cell Responses in Adult Volunteers to One of Three Regimens of Meningococcal ACWY Conjugate Vaccine or Meningococcal ACWY Polysaccharide Vaccine Priming Doses Followed by a Booster Dose of the Meningococcal ACWY Conjugate Vaccine	Completed	NCT01593514	Phase 4
28	The Impact of Vaccination With a Serogroup A Meningococcal Conjugate Vaccine on Carriage of Serogroup A Meningococci in Mali and Niger	Completed	NCT01119482	Phase 4
29	Evaluation of the Effect of Tetravalent (A, C, Y, W-135) Meningococcal Conjugate Vaccine on Serogroup-Specific Carriage of Neisseria Meningitidis	Completed	NCT00119080	Phase 4
30	Meningococcal (Groups A, C, Y, W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine (Menactra®) Post-Marketing Safety Study in Healthy Children (2-11 Years), Adolescents (12-17 Years) and Adults (18-55 Years) in the Philippines	Completed	NCT01270503	Phase 4
31	Safety and Immunogenicity of Sanofi Pasteur Meningococcal (Groups A and C) Polysaccharide Vaccine Versus Lanzhou Institute for Biological Products Meningococcal (Groups A and C) Polysaccharide Vaccine in Children 2-6 Years of Age in China	Completed	NCT01430611	Phase 4
32	Immunogenicity of Quadrivalent Meningococcal Conjugate Vaccine in Frequent Platelets Donors	Active, not recruiting	NCT04224311	Phase 4
33	Aciclovir for HSV-2 Meningitis: A Double-blind Randomised Controlled Trial (AMEN)	Not yet recruiting	NCT05452928	Phase 4	Acyclovir 50 MG/ML;Placebo
34	Mild Induced Hypothermia to Treat Severe Community Acquired Meningitis in Adults Admitted to Intensive Care Unit	Terminated	NCT00774631	Phase 4
35	Amikacin Penetration Into the Cerebrospinal Fluid: Pharmacokinetic/Pharmacodynamic Analysis in Adults With Hospital Acquired Gram-negative Meningitis Associated With Intracranial Pressure Monitoring and Draining Devices	Withdrawn	NCT00362245	Phase 4	Systemic and Intra-Thecal Amikacin Therapy
36	Cluster-randomized Trial to Evaluate the Impact of Ciprofloxacin Prophylaxis as a Response to a Meningococcal Meningitis Epidemic	Withdrawn	NCT03431675	Phase 4	Ciprofloxacin
37	Antifungal Treatment of Cryptococcal Meningitis	Unknown status	NCT04140461	Phase 3	Amphotericin B;Flucytosine
38	A Randomized, Double-Blind, Controlled, Non-inferiority Phase III Trial of a Group A Meningococcal Polysaccharide Vaccine in Healthy Infants Aged 6-15 Months	Unknown status	NCT04689165	Phase 3
39	A Randomized, Double-Blind, Controlled, Non-inferiority Phase III Trial of a Group A and C Meningococcal Polysaccharide Vaccine in Healthy Children Aged 2-6 Years	Unknown status	NCT04689191	Phase 3
40	Immunogenicity, Reactogenicity and Safety Assessment of the Meningococcal Serogroup C Vaccine Produced by Bio-Manguinhos / FIOCRUZ in Infants, Children and Adolescents	Unknown status	NCT02858570	Phase 2, Phase 3
41	Prospective Pilot Study to Evaluate a Standardized Management of Cryptococcal Meningitis in Patients Infected With HIV in Sub-Saharan Africa Involving an Initial Combination Therapy With Fluconazole and Flucytosine in High Doses, Complemented by Repeat Lumbar Punctures	Unknown status	NCT01715922	Phase 2, Phase 3	Fluconazole;Flucytosine
42	A Study of Safety and Immunogenicity of 10-valent and 13-valent Pneumococcal Conjugate Vaccines to Inform Policy Regarding Pneumococcal Vaccination of Papua New Guinean Children	Unknown status	NCT01619462	Phase 3
43	Rapid Diagnostic Tests in Association With Clinical and Laboratory Predictors for the Diagnosis of Neglected Tropical Diseases in Patients With Neurological Disorders in Rural Hospitals of Bandundu,Democratic Republic of Congo	Completed	NCT01589289	Phase 3
44	Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis	Completed	NCT01802385	Phase 3	Sertraline
45	Immunogenicity and Safety of a Booster Dose of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Adolescents and Adults	Completed	NCT02752906	Phase 3
46	Immunogenicity and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine Administered in Healthy Children 2 to 9 Years of Age	Completed	NCT03077438	Phase 3
47	Immunogenicity and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Toddlers 12 to 23 Months of Age.	Completed	NCT02955797	Phase 3
48	Immunogenicity and Safety of a Single Dose of a Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine (SP284) in Japanese Subjects	Completed	NCT01519713	Phase 3
49	Immunogenicity and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Adults Age 56 Years and Older	Completed	NCT02842866	Phase 3
50	Immune Lot Consistency, Immunogenicity, and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Adolescents and Adults Aged 10 to 55 Years	Completed	NCT02842853	Phase 3

Search NIH Clinical Center for Meningitis

Cochrane evidence based reviews: meningitis

Sources

Genetic Tests for Meningitis

Sources

Anatomical Context for Meningitis

Organs/tissues related to Meningitis:

MalaCards : Spinal Cord, Brain, Bone Marrow, Breast, Lung, Bone, Liver

Sources

Publications for Meningitis

Articles related to Meningitis:

(show top 50) (show all 31572)

#	Title	Authors	PMID	Year
1	Current state and practice variation in the use of Meningitis/Encephalitis (ME) FilmArray panel in children. ⁶² ⁴¹	Rajbhandari P...Snowden J	36316633	2022
2	Comparisons in the changes of clinical characteristics and cerebrospinal fluid cytokine profiles between varicella-zoster virus meningitis/encephalitis and other central nervous system infections. ⁶² ⁴¹	Ma C...Liu D	36411685	2022
3	Hypervirulent carbapenem-resistant Klebsiella pneumoniae causing highly fatal meningitis in southeastern China. ⁶² ⁴¹	Huang N...Ye J	36324461	2022
4	Comparative analysis of cerebrospinal fluid adenosine deaminase in tuberculous and non-tuberculous meningitis. ⁵³ ⁶²	Moghtaderi A...Narouie B	20399005	2010
5	Adenosine deaminase and tuberculous meningitis--a systematic review with meta-analysis. ⁵³ ⁶²	Tuon FF...Leite OM	20001225	2010
6	HLA-DRB1*01 allele and low plasma immunoglobulin G1 concentration may predispose to herpes-associated recurrent lymphocytic meningitis. ⁵³ ⁶²	Kallio-Laine K...Lokki ML	19879913	2010
7	Very late-onset group B Streptococcus meningitis, sepsis, and systemic shigellosis due to interleukin-1 receptor-associated kinase-4 deficiency. ⁵³ ⁶²	Krause JC...Creech CB	19814626	2009
8	[A case of listeria meningitis showed high levels of adenosine deaminase in cerebrospinal fluid]. ⁵³ ⁶²	Nakae Y...Kuroiwa Y	19928691	2009
9	Bacterial meningitis: rapid diagnosis and microbial profile: a multicentered study. ⁵³ ⁶²	Shameem S...Neelagund YF	19301695	2008
10	C-reactive protein as an indicator of aqueductal gliosis and hydrocephaly in neonatal meningitis. ⁵³ ⁶²	Hemmati F...Pishva N	18581011	2008
11	Comparative study of cerebrospinal fluid adenosine deaminase activity in patients with meningitis. ⁵³ ⁶²	Gautam N...Lamsal M	17899959	2007
12	A case of Listeria meningitis associated with increased adenosine deaminase in cerebrospinal fluid. ⁵³ ⁶²	Nishida Y...Mizusawa H	17141462	2007
13	Activin A concentrations in human cerebrospinal fluid are age-dependent and elevated in meningitis. ⁵³ ⁶²	Ebert S...Michel U	16920154	2006
14	Serum concentrations of interleukin-1 alpha, interleukin-6 and tumor necrosis factor-alpha in neonatal sepsis and meningitis. ⁵³ ⁶²	Fida NM...Fadelallah MF	17013473	2006
15	Expression of innate immune complement regulators on brain epithelial cells during human bacterial meningitis. ⁵³ ⁶²	Canova C...Gasque P	16948860	2006
16	Cerebrospinal fluid adenosine deaminase activity for the diagnosis of tuberculous meningitis in adults. ⁵³ ⁶²	Chotmongkol V...Yodwut C	17333738	2006
17	Interleukin-1alpha, interleukin-6 and tumor necrosis factor-alpha levels in children with sepsis and meningitis. ⁵³ ⁶²	Fida NM...Farouq M	16635168	2006
18	[Lymphocytis meningitis: Listeria monocytogenes is a potential risk in a immunocompetent child]. ⁵³ ⁶²	Flodrops H...Comoy J	16185855	2005
19	Shigella sonnei meningitis due to interleukin-1 receptor-associated kinase-4 deficiency: first association with a primary immune deficiency. ⁵³ ⁶²	Chapel H...Casanova JL	15825022	2005
20	Antibiotic susceptibility in relation to penicillin-binding protein genes and serotype distribution of Streptococcus pneumoniae strains responsible for meningitis in Japan, 1999 to 2002. ⁵³ ⁶²	Ubukata K...Sunakawa K	15105095	2004
21	[Concentration of proinflammatory cytokines (TNF-alpha, IL-8) in the cerebrospinal fluid and the course of bacterial meningitis]. ⁵³ ⁶²	Bociaga-Jasik M...Mach T	15230146	2004
22	Group B streptococcal beta-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis. ⁵³ ⁶²	Doran KS...Nizet V	12952922	2003
23	Expression of matrix metalloproteinases, sICAM-1 and IL-8 in CSF from children with meningitis. ⁵³ ⁶²	Shapiro S...Lerner A	12480084	2003
24	Neurotrophin-4 and glial cell line-derived neurotrophic factor in cerebrospinal fluid from meningitis/encephalitis patients. ⁵³ ⁶²	Tokunaga Y...Hara T	12213609	2002
25	Interleukin-8 levels in children with bacterial, tuberculous and aseptic meningitis. ⁵³ ⁶²	Yilmaz E...Aydinoglu H	12003295	2002
26	Worldwide variation in the incidence of Haemophilus influenzae type b meningitis and its association with ampicillin resistance. ⁵³ ⁶²	Gessner BD	11939404	2002
27	[Does the estimation of acute phase protein concentrations in cerebrospinal fluid and/or in serum in patients with viral meningitis carry diagnostic importance? Part I. Lymphocytic meningitis caused by epidemic parotitis]. ⁵³ ⁶²	Lobos M...Piatas S	12666587	2002
28	The possible role of cerebrospinal fluid adenosine deaminase activity in the diagnosis of tuberculous meningitis in adults. ⁵³ ⁶²	Choi SH...Woo JH	11792470	2002
29	Complement factor I deficiency associated with recurrent meningitis coinciding with menstruation. ⁵³ ⁶²	Gonzalez-Rubio C...Lopez-Trascasa M	11709004	2001
30	[Chemokines in meningitis of different etiologies]. ⁵³ ⁶²	Grygorczuk S...Hermanowska-Szpakowicz T	11320578	2001
31	Levels of three inflammation markers, C-reactive protein, serum amyloid A protein and procalcitonin, in the serum and cerebrospinal fluid of patients with meningitis. ⁵³ ⁶²	Shimetani N...Mori M	11763415	2001
32	Follistatin (FS) in human cerebrospinal fluid and regulation of FS expression in a mouse model of meningitis. ⁵³ ⁶²	Michel U...Nau R	11124865	2000
33	Adenosine deaminase levels in cerebrospinal fluid and serum in the diagnosis of tubercular meningitis. ⁵³ ⁶²	Chaturvedi P...Pramanick B	11191154	2000
34	Systemic neutralization of interleukin-8 markedly reduces neutrophilic pleocytosis during experimental lipopolysaccharide-induced meningitis in rabbits. ⁵³ ⁶²	Dumont RA...O'Reilly T	10992482	2000
35	[Serial measurement of anti-interleukin-8 IgG autoantibody in cerebrospinal fluid of infants with bacterial meningitis]. ⁵³ ⁶²	Takasaki J...Ogawa Y	11109762	2000
36	Serum C-reactive protein in the differential diagnosis of childhood meningitis. ⁵³ ⁶²	Tatara R...Imai H	11059546	2000
37	Fc gamma receptor allotypes in children with bacterial meningitis. A preliminary study. ⁵³ ⁶²	Tezcan I...Kanra G	10028861	1998
38	[Quantitative levels of serum amyloid A protein and other proteins in cerebrospinal fluid and serum of patients with meningitis]. ⁵³ ⁶²	Shimetani N...Ohtani H	9800479	1998
39	The production of macrophage inflammatory protein-1alpha in the cerebrospinal fluid at the initial stage of meningitis in children. ⁵³ ⁶²	Inaba Y...Shimbo T	9396559	1997
40	[Bacterial meningitis and CSF cytokines]. ⁵³ ⁶²	Ticca F...Vullo V	15034315	1997
41	[Evaluation of tumor necrosis factor and C-reactive protein level determination in cerebrospinal fluid of meningitis and encephalitis]. ⁵³ ⁶²	Kepa L...Adamek B	9424322	1997
42	[Detection of Neisseria meningitidis group B antigens by MB-Dot-Elisa test in patients with meningitis]. ⁵³ ⁶²	Alkmin MG...Shimizu SH	9162589	1997
43	[Nitric oxide, TNF-alpha and IL-8 in cerebrospinal fluids of tuberculous and cryptococcic meningitis]. ⁵³ ⁶²	Chen L...Wei C	10072993	1997
44	Detection of N. meningitidis group B antigens by MB-Dot-ELISA in patients with meningitis. ⁵³ ⁶²	Alkmin M das G...Shimizu SH	8897721	1996
45	Chemokines in the cerebrospinal fluid of patients with meningitis. ⁵³ ⁶²	Sprenger H...Gemsa D	8764560	1996
46	Interleukin-8 in cerebrospinal fluid from patients with septic and aseptic meningitis. ⁵³ ⁶²	Ostergaard C...Lundgren JD	8801091	1996
47	The use of adenosine deaminase activity as a biochemical marker for the diagnosis of tuberculous meningitis. ⁵³ ⁶²	Rohani MY...Rani JM	8935128	1995
48	Interleukin-8 in cerebrospinal fluid from patients with meningitis of different etiologies: its possible role as neutrophil chemotactic factor. ⁵³ ⁶²	Lopez-Cortes LF...Pachon J	7622911	1995
49	Adenosine deaminase in cerebrospinal fluid during brucella meningitis. ⁵³ ⁶²	da Cunha S	8522847	1995
50	Adenosine deaminase activity in the CSF of patients with aseptic meningitis: utility in the diagnosis of tuberculous meningitis or neurobrucellosis. ⁵³ ⁶²	Lopez-Cortes LF...Castillo J	7756471	1995

Sources

Genes for Meningitis

Genes related to Meningitis (0 elite genes):

(show top 50) (show all 54)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CRP	C-Reactive Protein	Protein Coding	22.64	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17013473 18581011 9350334 (more) 9271034 16635168 8493225 10829968 9800479 15602206 8577354 12666587 14514149 1293215 19664100 16185855 11059546 10595891 1878962 18399643 11763415 2283691 15735988 9424322 11806134 18341874 19301695 1560489 1766708
2	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	20.63	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10992482 10072993 7622911 (more) 1305908 12003295 9396559 8801091 16932228 8764560 15597225 9469457 8936005 15034315 19016627 11320578 15230146 10809261 11109762 12480084 15688294
3	CFP	Complement Factor Properdin	Protein Coding	20.36	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17062484
4	ADA	Adenosine Deaminase	Protein Coding	19.9	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17899959 7963633 17266837 (more) 8403061 11792470 17333738 9015506 19928691 8935128 8522847 7756471 20399005 20001225 11191154 17141462
5	IRAK4	Interleukin 1 Receptor Associated Kinase 4	Protein Coding	18.61	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15825022 19814626 18174872
6	TLR2	Toll Like Receptor 2	Protein Coding	18.51	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18837779
7	MBL2	Mannose Binding Lectin 2	Protein Coding	17.73	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10509505 19879913 20504205 (more) 18494378
8	CXCL1	C-X-C Motif Chemokine Ligand 1	Protein Coding	17.36	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8764560
9	TNF	Tumor Necrosis Factor	Protein Coding	16.54	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
10	CFI	Complement Factor I	Protein Coding	16.3	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11709004 9476132 18374984 (more) 16138437 16412054
11	IL6	Interleukin 6	Protein Coding	16.16	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
12	IL1B	Interleukin 1 Beta	Protein Coding	16.03	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
13	CCL4	C-C Motif Chemokine Ligand 4	Protein Coding	15.95	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10950803
14	IL10	Interleukin 10	Protein Coding	15.83	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
15	LYZ	Lysozyme	Protein Coding	15.77	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8403061 1560489
16	IFNG	Interferon Gamma	Protein Coding	15.35	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
17	ALB	Albumin	Protein Coding	15.33	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
18	CD46	CD46 Molecule	Protein Coding	15.28	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16948860
19	LACTB	Lactamase Beta	Protein Coding	15.26	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1889874 2203306 1398808 (more) 11939404 9410075
20	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	15.13	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
21	TLR4	Toll Like Receptor 4	Protein Coding	14.99	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
22	TLR9	Toll Like Receptor 9	Protein Coding	14.85	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
23	IL17A	Interleukin 17A	Protein Coding	14.84	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
24	CCL3	C-C Motif Chemokine Ligand 3	Protein Coding	14.78	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
25	FCGR2A	Fc Gamma Receptor IIa	Protein Coding	14.75	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11740730 10028861
26	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	14.66	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
27	MMP9	Matrix Metallopeptidase 9	Protein Coding	14.6	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
28	IL2	Interleukin 2	Protein Coding	14.58	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
29	CSF2	Colony Stimulating Factor 2	Protein Coding	14.4	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
30	CSF3	Colony Stimulating Factor 3	Protein Coding	14.39	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
31	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	14.3	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
32	IL4	Interleukin 4	Protein Coding	14.29	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
33	CD55	CD55 Molecule (Cromer Blood Group)	Protein Coding	14.25	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16948860
34	C3	Complement C3	Protein Coding	14.16	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
35	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	14.14	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
36	AQP4	Aquaporin 4	Protein Coding	14.11	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
37	IL18	Interleukin 18	Protein Coding	14	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
38	IL1A	Interleukin 1 Alpha	Protein Coding	13.89	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
39	IL5	Interleukin 5	Protein Coding	13.88	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
40	HLA-B	Major Histocompatibility Complex, Class I, B	Protein Coding	13.83	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8897721 9162589 11851955
41	GDNF	Glial Cell Derived Neurotrophic Factor	Protein Coding	13.82	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12213609
42	SAA4	Serum Amyloid A4, Constitutive	Protein Coding	13.8	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9800479 11763415
43	IL13	Interleukin 13	Protein Coding	13.77	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
44	LBP	Lipopolysaccharide Binding Protein	Protein Coding	13.68	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12932360
45	CASP1	Caspase 1	Protein Coding	13.63	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
46	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	13.59	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
47	CXCL2	C-X-C Motif Chemokine Ligand 2	Protein Coding	13.53	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
48	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	13.5	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
49	FN1	Fibronectin 1	Protein Coding	13.47	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
50	ENO2	Enolase 2	Protein Coding	13.47	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)

Sources

Variations for Meningitis

Sources

Expression for Meningitis

Search GEO for disease gene expression data for Meningitis.

Sources

Pathways for Meningitis

Pathways related to Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 76)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.87	CCL2 CCL4 CXCL1 CXCL8 IL10 IL1B
2	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.8	CCL2 CCL4 CD46 CFI CFP CRP
3	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.69	TNF IL6 IL1B IL10 IFNG CXCL8
4	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.58	TNF IL6 IL1B IL10 IFNG CXCL8
5	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.52	TNF TLR2 IRAK4 IL6 IL1B IL10
6	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.41	CCL2 CCL4 CXCL1 CXCL8 IFNG IL10
7	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.39	TNF IL6 IL1B IL10 CXCL8 CXCL1
8	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.91	TNF TLR2 MBL2 IRAK4 IL6 IL1B
9	Malignant pleural mesothelioma ⁷⁴	12.8	IL6 IL1B IL10 CXCL1 CCL4 CCL2
10	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.76	TNF TLR2 IRAK4 IL6 IL1B
11	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways IL1 signaling pathway ⁶⁷ Immune response IL-1 signaling pathway ²² Interleukin-1 (IL-1) structural pathway ⁷⁴ Interleukin-33 signaling ⁶⁶ Interleukin-36 pathway ⁶⁶ Mucin expression in CF via TLRs, EGFR signaling pathways ²² Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.73	CXCL8 IL1B IL6 IRAK4 TLR2 TNF
12	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.72	TNF IL6 IL1B IL10 IFNG CXCL1
13	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.71	TNF IL6 IL1B IL10 IFNG CXCL8
14	Complement cascade ⁶⁶ Show member pathways Activation of C3 and C5 ⁶⁶ Classical Complement Pathway ⁶⁴ Complement Pathway ⁶⁴ Complement system ⁷⁴ Complement system in neuronal development and plasticity ⁷⁴ Lectin Induced Complement Pathway ⁶⁴ Regulation of Complement cascade ⁶⁶	12.69	ALB CD46 CFI CFP CRP IFNG
15	Toll-Like receptor Signaling Pathways ⁶⁵ Show member pathways Inflammasome Activation Pathways ⁶⁵ Nanomaterial-induced inflammasome activation ⁷⁴ NOD-like Receptor Signaling Pathways ⁶⁵ TLR4 signaling and tolerance ⁷⁴ Toll-Like Receptors Pathway ⁶⁴	12.66	TNF TLR2 IRAK4 IL6 IL1B CXCL8
16	NF-kappaB Signaling ³	12.63	TNF TLR2 IRAK4 IL1B IL10 IFNG
17	Bacterial infections in CF airways ²² Show member pathways Altered glycosylation of MUC1 in tumor microenvironment ⁷⁴ IL-1 beta-dependent CFTR expression ²² IL1-mediated signaling events ⁶¹ Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²² NTHi-Induced Signaling ⁶⁴ Signal transduction through IL1R ⁷⁴	12.52	CXCL8 IFNG IL1B IL6 IRAK4 TLR2
18	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.46	CXCL8 IFNG IL1B IL6 IRAK4 TNF
19	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ⁶⁷ IL-17 signaling pathway ⁷⁴ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.42	TNF TLR2 IL6 CXCL8 CXCL1 CCL2
20	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12.3	TNF IL6 IL1B IL10 CXCL8
21	Colorectal Cancer Metastasis ⁶⁴	12.25	TNF TLR2 IL6 IFNG
22	Neuroinflammation and glutamatergic signaling ⁷⁴	12.24	TNF IL6 IL1B IL10 IFNG
23	Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions ⁶⁵ Show member pathways Chemokine receptors bind chemokines ⁶⁶	12.13	CXCL8 CXCL1 CCL4 CCL2
24	Immune response Lectin induced complement pathway ²² Show member pathways Immune response Alternative complement pathway ²² Immune response Classical complement pathway ²² Terminal pathway of complement ⁶⁶	12.11	MBL2 CRP CFP CFI CD46
25	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	12.09	IFNG IL10 IL6 TNF
26	Initial triggering of complement ⁶⁶ Show member pathways Alternative complement activation ⁶⁶ Alternative Complement Pathway ⁶⁴ Classical antibody-mediated complement activation ⁶⁶ Complement activation ⁷⁴ Complement Activation Pathways ⁶⁷ Creation of C4 and C2 activators ⁶⁶ Ficolins bind to repetitive carbohydrate structures on the target cell surface ⁶⁶ Lectin pathway of complement activation ⁶⁶	12.09	MBL2 CRP CFP CD46
27	Senescence and autophagy in cancer ⁷⁴	12.09	CXCL1 CXCL8 IFNG IL1B IL6
28	Interleukin-4 and Interleukin-13 signaling ⁶⁶	12.07	TNF IL6 IL1B IL10 CXCL8 CCL2
29	Allograft rejection ⁷⁴	12.02	TNF IL1B IL10 IFNG CXCL8
30	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	12.02	TNF TLR2 IL6 IL1B IL10 IFNG
31	Spinal cord injury ⁷⁴	12.01	CCL2 CXCL1 CXCL8 IFNG IL1B IL6
32	CCL18 signaling pathway ⁷⁴	12	IL6 IL10 CXCL8 CCL2
33	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.98	TLR2 IL6 IL1B IFNG
34	Innate Lymphoid Cells Differentiation ⁶⁵	11.92	TNF IL1B IL10 IFNG
35	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.9	TNF IL6 IL1B IL10 IFNG
36	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.89	IL6 CXCL8 CRP CCL2
37	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.87	TNF IL6 IL10 IFNG CRP
38	AP-1 transcription factor network ⁶¹	11.85	IL6 IL10 IFNG CXCL8 CCL2
39	Activation of NF-KappaB by PKR ⁶⁴ Show member pathways Canonical NF-kB pathway ⁷⁴ Cellular Transformation by HTLV1 ⁶⁴ Inhibition of PKR ⁶⁶ STING pathway in Kawasaki-like disease and COVID-19 ⁷⁴	11.83	TNF IL1B IFNG
40	Burn wound healing ⁷⁴	11.83	TNF IL6 IL1B CXCL8 CXCL1 CCL2
41	Glucocorticoid receptor regulatory network ⁶¹	11.81	IL6 IFNG CXCL8
42	Acute viral myocarditis ⁷⁴	11.8	IL6 IL10 IFNG
43	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.8	TNF IL6 IL1B IFNG CXCL8
44	IL 10 signaling pathway ⁶⁷	11.79	TNF IRAK4 IL6 IL1B IL10
45	Th17 cell differentiation pathway ⁷⁴	11.76	IL6 IL1B IFNG
46	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.76	TNF TLR2 IL6 IL10 IFNG
47	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ⁶¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ⁶¹	11.75	TNF IFNG CXCL8
48	Lung fibrosis ⁷⁴	11.73	TNF IL6 IL1B CXCL8 CCL4 CCL2
49	miRNAs involvement in the immune response in sepsis ⁷⁴	11.7	TNF IRAK4 IL6 IL10 CXCL8 CCL4
50	Non-genomic actions of 1,25 dihydroxyvitamin D3 ⁷⁴	11.69	TNF IL6 IFNG CXCL8 CCL2

Sources

GO Terms for Meningitis

Cellular components related to Meningitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10.13	ALB CCL2 CCL4 CFI CFP CRP
2	extracellular space	GO:0005615	9.83	ALB CCL2 CCL4 CFI CFP CRP

Biological processes related to Meningitis according to GeneCards Suite gene sharing:

(show all 50)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.6	TNF TLR2 IRAK4 IL6 IL1B IL10
2	innate immune response	GO:0045087	10.48	TLR2 MBL2 IRAK4 CRP CFP CFI
3	negative regulation of cell population proliferation	GO:0008285	10.38	CXCL1 CXCL8 IL10 IL1B IL6 TLR2
4	positive regulation of gene expression	GO:0010628	10.36	CD46 CRP CXCL8 IFNG IL1B IL6
5	defense response to bacterium	GO:0042742	10.34	TNF MBL2 LYZ IL10 CFP
6	positive regulation of DNA-binding transcription factor activity	GO:0051091	10.29	TNF IL6 IL1B IL10
7	positive regulation of inflammatory response	GO:0050729	10.28	TNF TLR2 IL1B IFNG
8	cellular response to type II interferon	GO:0071346	10.26	TNF TLR2 CCL4 CCL2
9	chemokine-mediated signaling pathway	GO:0070098	10.24	CCL2 CCL4 CXCL1 CXCL8
10	positive regulation of interleukin-8 production	GO:0032757	10.21	TNF TLR2 IL6 IL1B
11	humoral immune response	GO:0006959	10.2	CCL2 IFNG IL6 TNF
12	positive regulation of nitric oxide biosynthetic process	GO:0045429	10.18	TNF IL1B IFNG
13	positive regulation of interleukin-10 production	GO:0032733	10.18	TLR2 IL6 CD46
14	positive regulation of cytokine production	GO:0001819	10.18	TNF IL1B IL10 IFNG
15	positive regulation of interleukin-6 production	GO:0032755	10.18	TNF TLR2 IL6 IL1B IFNG
16	immune system process	GO:0002376	10.17	TLR2 MBL2 IRAK4 CFP CFI CD46
17	acute-phase response	GO:0006953	10.17	MBL2 IL6 CRP
18	positive regulation of receptor signaling pathway via JAK-STAT	GO:0046427	10.16	IL10 IL6 TNF
19	liver regeneration	GO:0097421	10.15	TNF IL6 IL10
20	regulation of insulin secretion	GO:0050796	10.15	IFNG IL1B IL6 TNF
21	microglial cell activation	GO:0001774	10.14	TNF TLR2 IFNG
22	negative regulation of neurogenesis	GO:0050768	10.13	TNF IL6 IL1B
23	positive regulation of glial cell proliferation	GO:0060252	10.1	TNF IL6 IL1B
24	positive regulation of nitric-oxide synthase biosynthetic process	GO:0051770	10.1	TLR2 IFNG CCL2
25	positive regulation of phagocytosis	GO:0050766	10.1	TNF MBL2 IL1B IFNG
26	lipopolysaccharide-mediated signaling pathway	GO:0031663	10.1	CCL2 IL1B TLR2 TNF
27	neutrophil chemotaxis	GO:0030593	10.1	CCL2 CCL4 CXCL1 CXCL8 IL1B
28	embryonic digestive tract development	GO:0048566	10.09	ADA CXCL8 TNF
29	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	10.08	TNF IL1B IFNG
30	positive regulation of heterotypic cell-cell adhesion	GO:0034116	10.07	TNF IL1B IL10
31	cellular response to lipopolysaccharide	GO:0071222	10.07	CCL2 CXCL1 CXCL8 IL10 IL1B IL6
32	astrocyte activation	GO:0048143	10.06	TNF IL1B IFNG
33	positive regulation of NMDA glutamate receptor activity	GO:1904783	10.01	IFNG CCL2
34	negative regulation of cytokine production involved in immune response	GO:0002719	10.01	TNF IL10
35	positive regulation of fever generation	GO:0031622	10	IL1B TNF
36	positive regulation of neuroinflammatory response	GO:0150078	10	TNF IL6 IL1B
37	defense response to Gram-positive bacterium	GO:0050830	10	TNF TLR2 MBL2 LYZ IL6 IL1B
38	sequestering of triglyceride	GO:0030730	9.99	TNF IL1B
39	negative regulation of lipid storage	GO:0010888	9.99	TNF IL6 CRP
40	leukocyte migration	GO:0050900	9.98	ADA IL1B TNF
41	positive regulation of nitrogen compound metabolic process	GO:0051173	9.97	IFNG TNF
42	positive regulation of chemokine production	GO:0032722	9.97	TNF TLR2 IL6 IL1B IFNG
43	inflammatory response	GO:0006954	9.96	CCL2 CCL4 CRP CXCL1 CXCL8 IL1B
44	chronic inflammatory response to antigenic stimulus	GO:0002439	9.95	IL10 TNF
45	positive regulation of vitamin D biosynthetic process	GO:0060557	9.95	IFNG TNF
46	response to molecule of bacterial origin	GO:0002237	9.93	TLR2 IL10 CXCL8
47	vascular endothelial growth factor production	GO:0010573	9.91	TNF IL6 IL1B
48	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.85	TNF IL1B IFNG
49	response to external stimulus	GO:0009605	9.75	TLR2 CXCL8 CXCL1
50	immune response	GO:0006955	9.5	TNF TLR2 IL6 IL1B IL10 IFNG