MCID: MNN013
MIFTS: 70

Meningitis

Categories: Neuronal diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Meningitis

Summaries for Meningitis

NINDS : 54 Meningitis is an infection of the meninges, the membranes that surround the brain and spinal cord. Encephalitis is inflammation of the brain itself. Anyone can get encephalitis or meningitis. Causes of encephalitis and meningitis include viruses, bacteria, fungus, and parasites. Anyone experiencing symptoms of meningitis or encephalitis should see a doctor immediately. Symptoms of encephalitis that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia. Other symptoms include: sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, irritability. In more severe cases, people may have problems with speech or hearing, vision problems, and hallucinations. Symptoms of meningitis, which may appear suddenly, often include: high fever, severe and persistent headache, stiff neck, nausea, sensitivity to bright light, vomiting, and changes in behavior such as confusion, sleepiness, and difficulty waking up. In infants, symptoms of meningitis or encephalitis may include fever, vomiting, lethargy, body stiffness, unexplained irritability, and a full or bulging fontanel (the soft spot on the top of the head).

MalaCards based summary : Meningitis is related to aseptic meningitis and viral meningitis, and has symptoms including back pain, fever and headache. An important gene associated with Meningitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Lamivudine and Amphotericin B have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related phenotypes are homeostasis/metabolism and immune system

Disease Ontology : 12 A central nervous system disease that is characterized by an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells.

MedlinePlus : 43 Meningitis is inflammation of the thin tissue that surrounds the brain and spinal cord, called the meninges. There are several types of meningitis. The most common is viral meningitis. You get it when a virus enters the body through the nose or mouth and travels to the brain. Bacterial meningitis is rare, but can be deadly. It usually starts with bacteria that cause a cold-like infection. It can cause stroke, hearing loss, and brain damage. It can also harm other organs. Pneumococcal infections and meningococcal infections are the most common causes of bacterial meningitis. Anyone can get meningitis, but it is more common in people with weak immune systems. Meningitis can get serious very quickly. You should get medical care right away if you have A sudden high fever A severe headache A stiff neck Nausea or vomiting Early treatment can help prevent serious problems, including death. Tests to diagnose meningitis include blood tests, imaging tests, and a spinal tap to test cerebrospinal fluid. Antibiotics can treat bacterial meningitis. Antiviral medicines may help some types of viral meningitis. Other medicines can help treat symptoms. There are vaccines to prevent some of the bacterial infections that cause meningitis. NIH: National Institute of Neurological Disorders and Stroke

CDC : 3 Meningitis is an inflammation (swelling) of the protective membranes covering the brain and spinal cord. A bacterial or viral infection of the fluid surrounding the brain and spinal cord usually causes the swelling. However, injuries, cancer, certain drugs, and other types of infections also can cause meningitis. It is important to know the specific cause of meningitis because the treatment differs depending on the cause.

Wikipedia : 76 Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord,... more...

Related Diseases for Meningitis

Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1045)
# Related Disease Score Top Affiliating Genes
1 aseptic meningitis 34.9 CXCL8 IL10 IL1B TNF
2 viral meningitis 34.7 ADA CRP CXCL8 IL6
3 meningococcal meningitis 34.3 CFP MBL2 TLR9
4 pneumococcal meningitis 33.7 MBL2 MMP9
5 tuberculous meningitis 33.5 ADA CXCL8 LYZ MMP9 TLR2 TNF
6 neurosyphilis 33.2 CXCL8 IL10 TLR2
7 listeriosis 33.0 IL10 IL6 MBL2 TNF
8 meningococcemia 32.6 CFP IL1B MBL2
9 streptococcal meningitis 32.6 ADA CD40LG CFP CRP MBL2 TNF
10 cerebral palsy 32.1 IL1B IL6 TNF
11 meningoencephalitis 32.0 ALB CD40LG IL6 TLR9
12 tuberculous peritonitis 31.9 ADA ALB CRP TNF
13 extrapulmonary tuberculosis 31.9 ADA IL10 IL1B MBL2 TLR2
14 neisseria meningitidis infection 31.9 CFP LACTB MBL2 TLR2
15 bacterial meningitis 31.3 ALB CFP CRP CXCL8 IL10 IL1B
16 haemophilus influenzae 31.3 CXCL8 IL1B TLR2 TNF
17 mycobacterium fortuitum 30.8 CXCL8 LACTB
18 osteomyelitis 30.8 CXCL8 IL1B IL6 TNF
19 lymphadenitis 30.8 CXCL8 IL10 IL1B TNF
20 hematopoietic stem cell transplantation 30.7 IL10 IL6 TNF
21 adult-onset still's disease 30.7 CRP IL1B IL6 TNF
22 pharyngitis 30.7 CRP CXCL8 IL1B
23 cellulitis 30.6 CRP LACTB TNF
24 leptospirosis 30.6 CD40LG CRP CXCL8 IL10 IL1B IL6
25 vaginitis 30.5 CXCL8 IL1B IL6
26 mycobacterium abscessus 30.5 CXCL8 TLR2 TNF
27 radiculopathy 30.5 CXCL8 IL10 IL6
28 brain edema 30.5 ALB IL1B IL6 MMP9
29 transverse myelitis 30.4 CXCL8 IL10 IL6 MMP9 TNF
30 rubella 30.4 CD40LG IL10 TNF
31 burns 30.4 ALB IL1B TNF
32 viral encephalitis 30.4 CXCL8 IL10 IL1B IL6 TNF
33 familial mediterranean fever 30.4 CRP IL1B TNF
34 pericardial effusion 30.4 ADA CRP IL6
35 mycobacterium chelonae 30.4 CXCL8 TLR2
36 infective endocarditis 30.4 CRP IL6 TLR2 TNF
37 purpura 30.3 CD40LG CRP TNF
38 diverticulitis 30.3 CRP MMP9 TNF
39 cystitis 30.3 CRP CXCL8 IL6 TNF
40 fasciitis 30.3 CXCL8 IL6 TNF
41 arthritis 30.2 CXCL8 IL10 IL1B IL6 MMP9 TNF
42 pertussis 30.2 IL10 IL1B IL6 TNF
43 duodenal ulcer 30.2 CXCL8 IL1B TNF
44 acute pancreatitis 30.2 CRP CXCL8 IL10 IL6
45 genital herpes 30.2 IL10 TLR2 TLR9
46 pyuria 30.2 ALB CRP CXCL8
47 psoriatic arthritis 30.2 CRP IL1B IL6 TNF
48 septic arthritis 30.2 CRP CXCL8 TLR2
49 prostatitis 30.1 CXCL8 IL10 IL1B IL6 TNF
50 louse-borne relapsing fever 30.1 CRP CXCL8 IL6 TNF

Comorbidity relations with Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis Chronic Meningitis
Deficiency Anemia Hypertension, Essential

Graphical network of the top 20 diseases related to Meningitis:



Diseases related to Meningitis

Symptoms & Phenotypes for Meningitis

UMLS symptoms related to Meningitis:


back pain, fever, headache, hemiplegia, meningism, pain, pruritus, sciatica, seizures, syncope, tremor, chronic pain, hyperexplexia, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to Meningitis:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.34 ADA CFP CRP IL10 ALB CD40LG
2 immune system MP:0005387 10.28 CFP CRP IL10 CD40LG IL1B ADA
3 hematopoietic system MP:0005397 10.27 ADA IL10 CD40LG IL1B TLR9 TNF
4 cardiovascular system MP:0005385 10.26 CFP ADA CRP IL10 CD40LG IL1B
5 cellular MP:0005384 10.25 ADA ALB IL10 CD40LG TLR2 TLR9
6 digestive/alimentary MP:0005381 10.15 ADA IL10 ALB TLR2 TLR9 TNF
7 endocrine/exocrine gland MP:0005379 10.13 ADA ALB IL10 CD40LG TLR2 TNF
8 mortality/aging MP:0010768 10.07 CFP ADA ALB IL10 CD40LG TLR2
9 integument MP:0010771 10.02 IL10 CD40LG IL1B TLR2 TNF IL6
10 liver/biliary system MP:0005370 9.87 ADA ALB IL10 TLR2 TNF IL6
11 neoplasm MP:0002006 9.81 IL10 ALB IL1B TNF TLR2 MMP9
12 renal/urinary system MP:0005367 9.61 ADA ALB CD40LG TLR2 TLR9 MBL2
13 skeleton MP:0005390 9.36 CFP ADA IL10 CD40LG IL1B TLR2

Drugs & Therapeutics for Meningitis

Drugs for Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 407)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lamivudine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 134678-17-4 60825
2
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1397-89-3 14956 5280965
3
Methotrexate Approved Phase 4,Phase 2 1959-05-2, 59-05-2 126941
4
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
5
Fluconazole Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 86386-73-4 3365
6
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 147-94-4 6253
7
Zidovudine Approved Phase 4,Not Applicable 30516-87-1 35370
8
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 22916-47-8 4189
9
Efavirenz Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 154598-52-4 64139
10
Ceftriaxone Approved Phase 4,Phase 3,Phase 1,Not Applicable 73384-59-5 5479530 5361919
11
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
12
Ampicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 69-53-4 6249
13
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
14
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
15
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
16
Cefoxitin Approved Phase 4,Phase 2 35607-66-0 441199
17
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-02-2 5743
18
Stavudine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 3056-17-5 18283
19
Acetaminophen Approved Phase 4,Phase 3,Not Applicable 103-90-2 1983
20
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613
21
Azathioprine Approved Phase 4 446-86-6 2265
22
Cefotaxime Approved Phase 4,Phase 2 63527-52-6 456256 5742673
23
Cosyntropin Approved Phase 4 16960-16-0 16129617
24
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 143 6006
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 59-30-3 6037
26
Lactitol Investigational Phase 4,Phase 2,Phase 3 585-86-4 3871
27
BCG vaccine Investigational Phase 4,Phase 2
28 Analgesics Phase 4,Phase 3,Phase 1,Phase 2
29 Renal Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
30 Reverse Transcriptase Inhibitors Phase 4,Phase 2,Phase 3,Not Applicable
31 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
32 Sodium Channel Blockers Phase 4,Not Applicable
33 Steroid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
34 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 1,Phase 2
35 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3,Phase 2
36 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
37 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
38 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
39 Topoisomerase Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
40 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
41 Dermatologic Agents Phase 4,Phase 2,Not Applicable
42 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Diuretics, Potassium Sparing Phase 4,Not Applicable
45 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
47 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
49 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
50 Antibodies Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 537)
# Name Status NCT ID Phase Drugs
1 Study on the Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. Unknown status NCT01478035 Phase 4 Phenytoin;placebo
2 Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis Unknown status NCT02686853 Phase 4 Liposomal amphotericin B
3 Kinetic of Immune Memory Response After Re-Vaccination With Meningococcal Vaccine Unknown status NCT00262015 Phase 4
4 Duration of Antibiotic Therapy in Community - Acquired Pneumonia Unknown status NCT01492387 Phase 4
5 Ciprofloxacin for the Prevention of Meningococcal Meningitis Completed NCT02724046 Phase 4 Ciprofloxacin
6 Infant Severe Sepsis and Bacterial Meningitis in Malawi Completed NCT01247909 Phase 4 Ceftriaxone v penicillin and gentamicin
7 Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis Completed NCT01540838 Phase 4 Infusion with paracetamol;Bolus without paracetamol
8 Optimal Time to Start Antiretroviral Therapy in HIV-infected Adults With Cryptococcal Meningitis Completed NCT00976040 Phase 4
9 Cryptococcal Optimal ART Timing Trial Completed NCT01075152 Phase 4 efavirenz
10 Pharmacological Study of High Doses of Ceftriaxone in Meningitidis Completed NCT01745679 Phase 4 Ceftriaxone treatment
11 Understanding the Immune Response to Two Different Meningitis Vaccines Completed NCT01593514 Phase 4
12 DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor Completed NCT00029523 Phase 4 Intrathecal (injected into the spinal fluid) DepoCyt;Intrathecal methotrexate;Intrathecal cytarabine (also known as ara-C)
13 Pertussis and Meningitis C Concomitant Vaccination in Adolescents Completed NCT02526394 Phase 4 Pertussis containing vaccine
14 Study on the Impact of Vaccination With a Conjugate Vaccine on Meningococcal Carriage Completed NCT01119482 Phase 4
15 A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents Completed NCT01424644 Phase 4
16 Post-Marketing Safety Study of Menactra® in Healthy Children, Adolescents, and Adults in the Philippines Completed NCT01270503 Phase 4
17 Safety and Immunogenicity of Intradermal Versus Subcutaneous Doses of Menomune® Completed NCT00850603 Phase 4
18 Persistence of Bactericidal Antibodies in Adults Who Received a Booster Dose of Menactra® Approximately 4 Years Earlier Completed NCT02633787 Phase 4
19 Effect of Meningococcal Conjugate Vaccine on Meningococcal Carriage Completed NCT00119080 Phase 4
20 Study of Sanofi Pasteur and Lanzhou Institute's Meningococcal (Group A and C) Polysaccharide Vaccine in Children Completed NCT01430611 Phase 4
21 Immunogenicity and Safety of Two-Dose Series of Menactra® in Japanese Healthy Adult Subjects Completed NCT02591290 Phase 4
22 Operational Research for Cryptococcal Antigen Screening Completed NCT01535469 Phase 4 Fluconazole
23 Fractional Dose Tetravalent A, C, Y, W135 Meningococcal Polysaccharide Vaccine Completed NCT00271479 Phase 4
24 Immune Response to Rotavirus Vaccine After a Supplemental Dose Given at 9 Months of Age With Local EPI Vaccines in Mali Completed NCT02286895 Phase 4
25 Persistence of Immunogenicity of MenACWY Conjugate Vaccine 5 Years After Childhood Vaccination, and Immune Response to a Booster Dose Completed NCT01823536 Phase 4
26 A Phase IV Study to Evaluate the Immunogenicity and Safety in UK Laboratory Workers of Menitorix Completed NCT00503165 Phase 4
27 Immunogenicity of 7-Valent Pneumococcal Conjugate Vaccine in Lung Fluid of Adults With and Without HIV Infection Completed NCT00371878 Phase 4
28 Study of Menactra® in US Adolescents When Administered Concomitantly With Tdap Vaccine Completed NCT00777257 Phase 4
29 Study of Evaluating Safety and Immunogenicity of 23-Valent Pneumococcal Polysaccharide Vaccine With Influenza Vaccine in Children and Adults Completed NCT02062281 Phase 4
30 Study of Menactra® in Healthy Subjects at 9 Months and Concomitantly With Pentacel® at 15 to 18 Months of Age Completed NCT01659996 Phase 4
31 Immunogenicity of 13-valent Pneumococcal Conjugate Vaccine Compared to the Pneumococcal Polysaccharide Vaccine in Adult Kidney and Liver Transplant Patients Completed NCT01781871 Phase 4
32 Pneumococcal Vaccination of Crohn Patients Completed NCT01947010 Phase 4
33 Protection Against Pneumococcal Infection in Children With T1DM Completed NCT01939522 Phase 4
34 The Effect of Live Attenuated Inactivated Influenza Vaccine on Experimental Human Pneumococcal Carriage Study Completed NCT03502291 Phase 4
35 Induction of Immunity Against Streptococcus Pneumoniae in Adults With Inflammatory Bowel Disease Completed NCT01908283 Phase 4
36 A Trial Comparing Two Pertussis-containing Vaccines in Pregnancy and Vaccine Responses in UK Mothers and Their Infants Completed NCT02145624 Phase 4 Repevax;Boostrix-IPV
37 Immunogenicity of 3+1 Versus 2+1 Schedule for PCV7 Completed NCT02040402 Phase 4
38 Cosyntropin Versus Epidural Blood Patch (EBP) for Treatment of Treatment of Post Dural Puncture Headache Completed NCT02394457 Phase 4 Cosyntropin
39 Study Evaluating the Safety and Ability to Produce Immune Response of Prevenar and Meningitec Given at the Same Time Completed NCT00581035 Phase 4
40 Safety and Efficacy Study of Flebogamma 5% DIF IGIV in Pediatric Subjects Completed NCT00634569 Phase 4
41 Evaluation of Meningococcal C Vaccine Programmes in Canadian Children Completed NCT00936962 Phase 4
42 Determination of Gentamicin Dosing in Neonatal Patients Completed NCT00198601 Phase 4 Gentamicin in Uniject Pre-filled syringe
43 Persistence of Antibody Response to N. Meningitidis Group C in Children Completed NCT00316654 Phase 4
44 Kinetics of B Cell Response in Infants Menjugate Vaccination Completed NCT00310700 Phase 4
45 Persistence of Immune Response After Vaccination With MCC Completed NCT00310687 Phase 4
46 Persistence of Antibodies and Kinetics of B Cell Response in Healthy Children After Vaccination With MCC Vaccine Completed NCT00310713 Phase 4
47 A Sourcing Study to Collect Human Blood Samples From Healthy Adults Recruiting NCT03493919 Phase 4
48 Impact of Cotrimoxazole Use in Immunocompetent HIV Patients on Carriage of Antimicrobial Resistant Bacteria Recruiting NCT03087890 Phase 4 Cotrimoxazole;Placebo
49 Antibiotic Prophlaxis for High-risk Laboring Women in Low Income Countries Recruiting NCT03248297 Phase 4 Azithromycin;Azithromycin and amoxicillin;Placebo
50 Investigating the Immune Response to 4CMenB in Infants Active, not recruiting NCT02080559 Phase 4

Search NIH Clinical Center for Meningitis

Cochrane evidence based reviews: meningitis

Genetic Tests for Meningitis

Genetic tests related to Meningitis:

# Genetic test Affiliating Genes
1 Meningitis 29

Anatomical Context for Meningitis

MalaCards organs/tissues related to Meningitis:

41
Brain, Spinal Cord, Testes, Bone, B Cells, Pituitary, T Cells

Publications for Meningitis

Articles related to Meningitis:

(show top 50) (show all 6188)
# Title Authors Year
1
Cryptococcal meningitis in a daily cannabis smoker without evidence of immunodeficiency. ( 29374632 )
2018
2
Spinal meningeal melanocytoma in a 5-year-old child: a case report and review of literature. ( 29780233 )
2018
3
A study on correlations of procalcitonin and interleukin-6 with viral meningitis. ( 29917201 )
2018
4
Draft Genome Sequences of Five Neonatal Meningitis-Causing Escherichia coli Isolates (SP-4, SP-5, SP-13, SP-46, and SP-65). ( 29674529 )
2018
5
Pulmonary alveolar proteinosis following cryptococcal meningitis: a possible cause? ( 29592982 )
2018
6
A refugee patient with meningococcal meningitis type B. ( 29757696 )
2018
7
Novel Treatment of Cryptococcal Meningitis via NeurapheresisTM Therapy. ( 29788431 )
2018
8
A Rare Case of<i>Sphingomonas paucimobilis</i>Meningitis in the Absence of Cerebrospinal Fluid Pleocytosis. ( 29435467 )
2018
9
The first report of human meningitis and pyogenic ventriculitis caused by Streptococcus suis: A case report. ( 29429850 )
2018
10
Cerebral tryptophan metabolism and outcome of tuberculous meningitis: an observational cohort study. ( 29395996 )
2018
11
Arachnoid diverticulum diagnosis following treatment of cryptococcal meningitis in a dog. ( 29636913 )
2018
12
Paradoxical Reaction in a Patient with Co-Occurring Tuberculous Meningitis and Pott's Disease. ( 29907737 )
2018
13
Tigecycline in the treatment of multidrug-resistant Acinetobacter baumannii meningitis: Results of the Ege study. ( 29960893 )
2018
14
Scrub Typhus Meningitis Versus Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396931 )
2018
15
The first case report of Enterococcus gallinarum meningitis in neonate: A literature review. ( 29443752 )
2018
16
Utility of magnetic resonance cisternography with intrathecal gadolinium in detection of cerebrospinal fluid fistula associated with Mondini dysplasia in a patient with recurrent meningitis: Case report and literature review. ( 29770252 )
2018
17
Duplex recombinase polymerase amplification assays incorporating competitive internal controls for bacterial meningitis detection. ( 29378166 )
2018
18
Cerebrospinal Fluid Lactate as a Prognostic Indicator in Postneurosurgical Bacterial Meningitis and Use of Intrathecal Colistin. ( 29743769 )
2018
19
Diagnosis of tuberculous meningitis with invasive pulmonary sampling. ( 29303733 )
2018
20
Antiphospholipid Syndrome Complicating Pneumococcal Meningitis. ( 29845960 )
2018
21
Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing. ( 29710329 )
2018
22
Delayed Cerebral Injury in Adults With Bacterial Meningitis: A Novel Complication of Adjunctive Steroids? ( 29746358 )
2018
23
A world without bacterial meningitis: how genomic epidemiology can inform vaccination strategy. ( 29636909 )
2018
24
Meningococcal meningitis with neurological complications and meningococcemia due to serogroup W sequence type 11 complex. ( 29373268 )
2018
25
Acral-accentuated exanthem in an infant with parechovirus meningitis. ( 29205494 )
2018
26
Adult-Onset Recurrent Bacterial Meningitis: Immunological Red Herrings. ( 29401276 )
2018
27
Development of a clinical prediction rule for tuberculous meningitis in adults in Lima, Peru. ( 29446860 )
2018
28
Neonatal meningitis and recurrent bacteremia with group B Streptococcus transmitted by own mother's milk: A case report and review of previous cases. ( 29959094 )
2018
29
Acute streptococcal meningitis presenting as bilateral conductive hearing loss. ( 29655501 )
2018
30
A Child With Intermittent Headaches and Eosinophilic Meningitis. ( 29438532 )
2018
31
Cystic Encephalomalacia following Vasculopathy and Vasospasm of Proximal Intracranial Arteries Due to Pneumococcal Meningitis in a Infant. ( 29523004 )
2018
32
Using Predictive Model for Screening Bacterial Meningitis in National Surveillance System in Iran. ( 29968622 )
2018
33
Invasive Pomacea snails as important intermediate hosts of Angiostrongylus cantonensis in Laos, Cambodia and Vietnam: Implications for outbreaks of eosinophilic meningitis. ( 29574000 )
2018
34
Cryptococcal meningitis: an unusual presentation of primary HIV infection. ( 29966507 )
2018
35
Community acquired <i>Klebsiella pneumoniae</i> meningitis: a case report. ( 29951382 )
2018
36
Cerebrospinal fluid monocytes in bacterial meningitis, viral meningitis, and neuroborreliosis. ( 29628177 )
2018
37
Adjuvant non-bacteriolytic and anti-inflammatory combination therapy in pneumococcal meningitis: an investigation in a mouse model. ( 29649601 )
2018
38
The novel fungal CYP51 inhibitor VT-1598 is efficacious alone and in combination with liposomal amphotericin B in a murine model of cryptococcal meningitis. ( 29947783 )
2018
39
Listeria Meningitis during Infliximab-based Treatment for Ulcerative Colitis. ( 29607962 )
2018
40
Miliary Tuberculosis Presenting With Meningitis in a Patient Treated With Mycophenolate for Lupus Nephritis: Challenges in Diagnosis and Review of the Literature. ( 29707591 )
2018
41
Diagnosis of Meningitis Caused by Pathogenic Microorganisms Using Magnetic Resonance Imaging: A Systematic Review. ( 29967667 )
2018
42
Detection of Bacterial Meningitis Pathogens by PCR-Mass Spectrometry in Cerebrospinal Fluid. ( 29945321 )
2018
43
<i>Burkholderia multivorans:</i> A rare yet emerging cause of bacterial meningitis. ( 29619322 )
2018
44
A Fatal Case of Undiagnosed Candida Meningitis: Role of Computer-assisted Diagnosis. ( 29953039 )
2018
45
Use of Linezolid in a Child With Tuberculous Meningitis. ( 29652742 )
2018
46
Meningoencephalocele causing recurrent meningitis. ( 29744093 )
2018
47
Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States. ( 29244019 )
2018
48
Community-Acquired Meningitis in HIV-Infected Patients in the United States. ( 29432047 )
2018
49
Absence of cerebrospinal fluid pleocytosis in tuberculous meningitis is a common occurrence in HIV co-infection and a predictor of poor outcomes. ( 29391245 )
2018
50
Current status of cerebrospinal meningitis and impact of the 2015 meningococcal C vaccination in Kebbi, Northwest Nigeria. ( 29426659 )
2018

Variations for Meningitis

Expression for Meningitis

Search GEO for disease gene expression data for Meningitis.

Pathways for Meningitis

Pathways related to Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 CCL4 CD40LG CFP CRP CXCL1 CXCL8
2
Show member pathways
13.48 CCL4 CD40LG CXCL1 CXCL8 IL10 IL1B
3
Show member pathways
13.46 CCL4 CD40LG CXCL1 CXCL8 IL10 IL1B
4
Show member pathways
13.36 CCL4 CD40LG CXCL1 CXCL8 IL10 IL1B
5
Show member pathways
12.93 CD40LG CXCL8 IL10 IL1B IL6 TNF
6
Show member pathways
12.89 CFP CXCL8 IL1B IL6 IRAK4 TLR2
7
Show member pathways
12.85 CCL4 CXCL1 CXCL8 IL10 IL1B IL6
8
Show member pathways
12.82 CD40LG IL1B IL6 IRAK4 TLR2 TLR9
9
Show member pathways
12.79 CCL4 CXCL8 IL1B IL6 TNF
10
Show member pathways
12.7 CXCL8 IL10 IL1B IL6 TNF
11 12.68 CD40LG IL10 IL1B IRAK4 TLR2 TLR9
12
Show member pathways
12.66 CXCL1 CXCL8 IL6 MMP9 TLR2 TNF
13
Show member pathways
12.64 CXCL1 IL10 IL1B IL6 TNF
14
Show member pathways
12.62 CD40LG IL1B IRAK4 TLR2 TLR9 TNF
15
Show member pathways
12.51 IL10 IL1B IL6 TLR2 TNF
16
Show member pathways
12.5 CD40LG IL10 IL1B IL6 TNF
17
Show member pathways
12.42 CXCL1 CXCL8 IL1B IL6 MMP9 TLR2
18
Show member pathways
12.41 ALB CRP IL1B IL6 TNF
19
Show member pathways
12.39 CXCL8 IL6 IRAK4 TLR2 TLR9 TNF
20
Show member pathways
12.38 IL10 IL1B IL6 TLR2 TLR9 TNF
21
Show member pathways
12.38 CD40LG IL10 IL1B IRAK4 TLR2 TNF
22
Show member pathways
12.37 CXCL8 IL1B IL6 IRAK4 TNF
23
Show member pathways
12.34 CXCL8 IL1B IL6 IRAK4 TLR2 TNF
24
Show member pathways
12.31 IL10 IL1B IL6 TLR9 TNF
25 12.29 IL10 IL1B IL6 IRAK4 TLR2 TLR9
26 12.28 IL6 MMP9 TLR2 TLR9 TNF
27 12.27 CXCL8 IL10 IL1B IL6 TNF
28
Show member pathways
12.24 CXCL8 IL1B IL6 IRAK4 TLR2 TLR9
29
Show member pathways
12.13 CCL4 CXCL8 IL10 IL1B IL6
30 12.13 CXCL1 CXCL8 IL1B IL6 MMP9 TNF
31 12.09 CXCL1 IL1B IL6 MMP9 TNF
32 12.09 CXCL8 IL10 IL1B IL6 MMP9 TNF
33 12.01 CXCL1 CXCL8 IL1B IL6
34 11.99 CCL4 CD40LG CXCL8 IL1B IRAK4 TNF
35 11.98 CXCL8 IL1B IL6 TNF
36 11.97 CCL4 CXCL1 CXCL8 IL1B IL6
37 11.94 CXCL1 CXCL8 IL1B IL6 TLR2 TNF
38 11.87 IL10 IL1B IL6 TLR9 TNF
39 11.8 IL10 IL1B TNF
40 11.79 CXCL8 IL10 IL1B IL6 IRAK4 TNF
41
Show member pathways
11.78 CD40LG CXCL8 TNF
42 11.71 CXCL8 IL6 MMP9
43 11.68 CCL4 CXCL8 IL1B IL6 MMP9 TNF
44 11.68 CXCL1 CXCL8 IL10 IL1B IL6 TLR2
45
Show member pathways
11.64 CD40LG CXCL8 IL1B IL6 MMP9 TNF
46 11.57 IL6 MMP9 TNF
47 11.57 IL1B TLR2 TNF
48 11.54 IL1B IL6 TNF
49 11.54 CXCL1 CXCL8 IL1B IL6 TLR2 TNF
50 11.5 IL10 IL1B IL6 TNF

GO Terms for Meningitis

Cellular components related to Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 ALB CCL4 CD40LG CFP CRP CXCL1
2 extracellular space GO:0005615 9.58 ADA ALB CCL4 CD40LG CFP CRP
3 tertiary granule lumen GO:1904724 9.46 CFP CXCL1 LYZ MMP9
4 specific granule lumen GO:0035580 9.43 CFP CXCL1 LYZ

Biological processes related to Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.99 IL1B IRAK4 TLR9 TNF
2 defense response to bacterium GO:0042742 9.97 CFP IL10 LYZ MBL2 TLR9 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.96 CXCL8 IL10 IL6 TNF
4 response to lipopolysaccharide GO:0032496 9.96 CXCL1 CXCL8 IL10 IL1B TLR2
5 positive regulation of DNA binding transcription factor activity GO:0051091 9.92 IL10 IL1B IL6 TNF
6 positive regulation of inflammatory response GO:0050729 9.9 CCL4 TLR2 TLR9
7 chemokine-mediated signaling pathway GO:0070098 9.89 CCL4 CXCL1 CXCL8
8 positive regulation of JNK cascade GO:0046330 9.89 IL1B TLR9 TNF
9 neutrophil chemotaxis GO:0030593 9.89 CCL4 CXCL8 IL1B
10 response to glucocorticoid GO:0051384 9.89 IL10 IL6 TNF
11 positive regulation of T cell proliferation GO:0042102 9.88 CD40LG IL1B IL6
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.87 IL6 IRAK4 TNF
13 toll-like receptor signaling pathway GO:0002224 9.85 IRAK4 TLR2 TLR9
14 immune response GO:0006955 9.85 CCL4 CD40LG CFP CXCL1 CXCL8 IL10
15 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.84 IL10 MMP9 TNF
16 acute-phase response GO:0006953 9.83 CRP IL6 MBL2
17 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.83 IL1B TLR2 TLR9 TNF
18 positive regulation of phagocytosis GO:0050766 9.82 IL1B MBL2 TNF
19 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.8 IRAK4 TLR2 TLR9
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 IL1B TLR2 TNF
21 positive regulation of interleukin-6 production GO:0032755 9.8 IL1B IL6 TLR2 TLR9 TNF
22 defense response to Gram-positive bacterium GO:0050830 9.8 CRP IL6 LYZ MBL2 TLR2 TNF
23 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 CD40LG IL1B IL6 IRAK4 TLR2 TLR9
24 negative regulation of interleukin-6 production GO:0032715 9.79 IL10 TLR9 TNF
25 positive regulation of interleukin-12 production GO:0032735 9.78 CD40LG TLR2 TLR9
26 positive regulation of interleukin-8 production GO:0032757 9.78 IL1B TLR2 TLR9 TNF
27 positive regulation of leukocyte chemotaxis GO:0002690 9.77 CXCL1 CXCL8 IL6
28 positive regulation of interleukin-10 production GO:0032733 9.77 CD40LG TLR2 TLR9
29 positive regulation of chemokine production GO:0032722 9.76 IL6 TLR2 TLR9 TNF
30 embryonic digestive tract development GO:0048566 9.74 ADA CXCL8 TNF
31 I-kappaB phosphorylation GO:0007252 9.73 TLR2 TLR9
32 regulation of cytokine secretion GO:0050707 9.73 TLR2 TLR9
33 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.73 IL1B TLR9
34 neutrophil mediated immunity GO:0002446 9.72 IL6 IRAK4
35 negative regulation of growth of symbiont in host GO:0044130 9.72 IL10 MBL2 TNF
36 opsonization GO:0008228 9.71 CRP MBL2
37 positive regulation of chemokine biosynthetic process GO:0045080 9.71 IL1B TNF
38 regulation of circadian sleep/wake cycle, sleep GO:0045187 9.71 ADA PTGDS
39 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL10 IL1B TNF
40 endothelial cell apoptotic process GO:0072577 9.7 IL10 TNF
41 regulation of establishment of endothelial barrier GO:1903140 9.7 IL1B TNF
42 negative regulation of cytokine secretion involved in immune response GO:0002740 9.69 IL10 TNF
43 negative regulation of interleukin-8 production GO:0032717 9.69 IL10 TLR9
44 negative regulation of lipid storage GO:0010888 9.69 CRP IL6 TNF
45 positive regulation of fever generation GO:0031622 9.68 IL1B TNF
46 regulation of immunoglobulin secretion GO:0051023 9.68 CD40LG TNF
47 positive regulation of toll-like receptor signaling pathway GO:0034123 9.68 TLR2 TLR9
48 tumor necrosis factor production GO:0032640 9.67 TLR2 TLR9
49 sequestering of triglyceride GO:0030730 9.67 IL1B TNF
50 positive regulation of interleukin-18 production GO:0032741 9.67 TLR2 TLR9

Molecular functions related to Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 ALB CCL4 CRP LACTB LYZ MMP9
2 chemokine activity GO:0008009 9.33 CCL4 CXCL1 CXCL8
3 cytokine activity GO:0005125 9.23 CCL4 CD40LG CXCL1 CXCL8 IL10 IL1B
4 interleukin-1 receptor binding GO:0005149 9.13 IL1B IRAK4 TLR9

Sources for Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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