MCID: MNN013
MIFTS: 66

Meningitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Meningitis

MalaCards integrated aliases for Meningitis:

Name: Meningitis 11 75 53 41 2 43 14 71
Fungal Meningitis Due to Cryptococcus Neoformans 33
Cryptococcal Meningoencephalitis 33
Meningitis Due to H. Influenzae 33
Acute Streptococcal Meningitis 33
Meningitis Due to Cryptococcus 33
Staphylococcal Meningitis 33
Cryptococcosis Meningitis 33
Streptococcal Meningitis 33
Cryptococcal Meningitis 33
Cryptococcus Meningitis 33
Mumps Virus Meningitis 33
Adenoviral Meningitis 33
Influenzal Meningitis 33
Influenza Meningitis 33
Mumps Meningitis 33

Classifications:



External Ids:

Disease Ontology 11 DOID:9471
ICD9CM 34 322.9
MeSH 43 D008581
NCIt 49 C26828
SNOMED-CT 68 154983000
ICD10 31 G03 G03.8 G03.9
UMLS 71 C0025289

Summaries for Meningitis

MedlinePlus: 41 Meningitis is inflammation of the thin tissue that surrounds the brain and spinal cord, called the meninges. There are several types of meningitis. The most common is viral meningitis. You get it when a virus enters the body through the nose or mouth and travels to the brain. Bacterial meningitis is rare, but can be deadly. It usually starts with bacteria that cause a cold-like infection. It can cause stroke, hearing loss, and brain damage. It can also harm other organs. Pneumococcal infections and meningococcal infections are the most common causes of bacterial meningitis. Anyone can get meningitis, but it is more common in people with weak immune systems. Meningitis can get serious very quickly. You should get medical care right away if you have: A sudden high fever A severe headache A stiff neck Nausea or vomiting Early treatment can help prevent serious problems, including death. Tests to diagnose meningitis include blood tests, imaging tests, and a spinal tap to test cerebrospinal fluid. Antibiotics can treat bacterial meningitis. Antiviral medicines may help some types of viral meningitis. Other medicines can help treat symptoms. There are vaccines to prevent some of the bacterial infections that cause meningitis. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary: Meningitis, also known as fungal meningitis due to cryptococcus neoformans, is related to meningococcal meningitis and tuberculous meningitis, and has symptoms including tremor, fever and back pain. An important gene associated with Meningitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are ERK Signaling and Innate Immune System. The drugs Phenytoin and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone marrow, and related phenotypes are homeostasis/metabolism and cardiovascular system

CDC: 2 Meningitis is an inflammation (swelling) of the protective membranes covering the brain and spinal cord. A bacterial or viral infection of the fluid surrounding the brain and spinal cord usually causes the swelling. However, injuries, cancer, certain drugs, and other types of infections also can cause meningitis. It is important to know the specific cause of meningitis because the treatment differs depending on the cause.

Disease Ontology: 11 A central nervous system disease that is characterized by an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells.

Wikipedia: 75 Meningitis is acute or chronic inflammation of the protective membranes covering the brain and spinal... more...

Related Diseases for Meningitis

Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2054)
# Related Disease Score Top Affiliating Genes
1 meningococcal meningitis 33.4 TLR2 MBL2 CFP
2 tuberculous meningitis 33.4 LYZ ADA
3 aseptic meningitis 33.2 TNF IL6 IL1B IL10 CXCL8 CRP
4 viral meningitis 33.1 TNF IL6 IFNG CXCL8 CRP CCL2
5 fungal meningitis 33.1 TNF IL6 IL10 IFNG CRP ALB
6 cryptococcal meningitis 33.0 TNF IL6 IL10 IFNG ALB ADA
7 lymphocytic choriomeningitis 32.9 TLR2 IL6 CXCL8
8 bacterial meningitis 32.7 TNF TLR2 LYZ LACTB IL1B IL10
9 chronic meningitis 32.7 IL1B CRP ALB
10 listeriosis 32.4 TNF TLR2 MBL2 IL6 IL1B IL10
11 meningoencephalitis 32.4 TNF IL6 IL1B IL10 CRP ALB
12 haemophilus influenzae 32.4 TNF TLR2 LACTB IL1B CXCL8
13 meningococcal infection 32.4 TLR2 MBL2 LACTB CFP CD46
14 cryptococcosis 32.3 TNF MBL2 IL10 IFNG
15 vogt-koyanagi-harada disease 32.2 TNF IL6 IL10
16 viral encephalitis 32.1 TNF IL6 IL1B IL10 CCL2
17 cysticercosis 32.1 IL6 IL1B IL10
18 neurosyphilis 32.1 TLR2 IL10 CXCL8
19 leptospirosis 32.1 TNF TLR2 IL6 IL1B IL10 IFNG
20 bacteremia 2 32.0 MBL2 LACTB CRP
21 spinal cord disease 32.0 TNF IL6 IL10 ALB
22 mannose-binding lectin deficiency 32.0 MBL2 IL6
23 tuberculous peritonitis 31.9 IFNG CRP ALB ADA
24 cerebral palsy 31.8 TNF MBL2 IL6 IL1B IL10 CXCL8
25 encephalitis 31.8 TNF TLR2 IL6 IL1B IL10 CXCL8
26 arachnoiditis 31.8 TNF IL1B IFNG CRP
27 behcet syndrome 31.8 TNF TLR2 MBL2 IL6 IL1B IL10
28 extrapulmonary tuberculosis 31.8 TNF TLR2 IL6 IL1B IL10 IFNG
29 herpes zoster 31.7 TLR2 IL10 IFNG
30 intracranial hypertension 31.7 TNF IL6 IL1B CRP ALB
31 west nile encephalitis 31.6 TNF IL6 IL1B IL10 IFNG CRP
32 acquired immunodeficiency syndrome 31.6 TNF IL6 IL1B IL10 IFNG CRP
33 human immunodeficiency virus type 1 31.6 IL10 IFNG CXCL1 CCL4 CCL2
34 headache 31.6 TNF CXCL8 ALB
35 myelitis 31.5 TNF IL6 IL10 CXCL8
36 exanthem 31.5 TNF IL6 IL1B IL10 IFNG CXCL8
37 mumps 31.5 TNF IL6 IL1B IL10 IFNG CXCL8
38 pleural empyema 31.5 IL6 CRP ALB ADA
39 chickenpox 31.5 TNF IL6 IL1B IL10 IFNG CRP
40 miliary tuberculosis 31.5 TNF IL10 IFNG CRP ALB ADA
41 vasculitis 31.5 TNF MBL2 IL6 IL1B IL10 CXCL8
42 toxic shock syndrome 31.5 TNF TLR2 IL6 IL1B IL10 IFNG
43 labyrinthitis 31.4 TNF IL1B CRP
44 bell's palsy 31.4 TNF IL6 CRP ALB
45 stroke, ischemic 31.4 TNF IL6 IL1B CXCL1 CRP ALB
46 cranial nerve palsy 31.4 TNF CRP ALB
47 papilledema 31.4 IL6 CRP ALB
48 inappropriate adh syndrome 31.4 IL6 CRP ALB
49 poliomyelitis 31.4 TNF IL6 IL10 IFNG ALB
50 intracranial abscess 31.3 LACTB CRP

Comorbidity relations with Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis Chronic Meningitis
Deficiency Anemia Hypertension, Essential

Graphical network of the top 20 diseases related to Meningitis:



Diseases related to Meningitis

Symptoms & Phenotypes for Meningitis

UMLS symptoms related to Meningitis:


tremor; fever; back pain; headache; pruritus; syncope; hemiplegia; pain; chronic pain; sciatica; seizures; vertigo/dizziness; sleeplessness; meningism; hyperexplexia

GenomeRNAi Phenotypes related to Meningitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.17 ADA ALB CCL2 CCL4 CD46 CFI
2 no effect GR00402-S-2 10.17 ADA ALB CCL2 CCL4 CD46 CFI

MGI Mouse Phenotypes related to Meningitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.3 ADA ALB CCL2 CFI CFP CRP
2 cardiovascular system MP:0005385 10.13 ADA ALB CCL2 CD46 CFP CRP
3 neoplasm MP:0002006 10.11 ALB CCL2 IFNG IL10 IL1B IL6
4 muscle MP:0005369 10.09 ADA ALB CCL2 IFNG IL10 IL6
5 liver/biliary system MP:0005370 10.06 ADA ALB CCL2 IFNG IL10 IL6
6 immune system MP:0005387 10.06 ADA ALB CCL2 CFI CFP CRP
7 digestive/alimentary MP:0005381 9.97 ADA ALB CCL2 IFNG IL10 IL6
8 skeleton MP:0005390 9.77 ADA CCL2 CFP CXCL1 IFNG IL10
9 hematopoietic system MP:0005397 9.44 ADA CCL2 CFI CXCL1 IFNG IL10

Drugs & Therapeutics for Meningitis

Drugs for Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 271)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
2
Acetaminophen Approved Phase 4 103-90-2 1983
3
Cefotaxime Approved Phase 4 63527-52-6 5742673 456256
4
Lactitol Approved, Investigational Phase 4 585-86-4 157355
5
Ceftriaxone Approved Phase 4 73384-59-5 5479530
6
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
7
Stavudine Approved, Investigational Phase 4 3056-17-5 18283
8
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
9
Zidovudine Approved Phase 4 30516-87-1 35370
10
Levoleucovorin Approved, Experimental, Investigational Phase 4 68538-85-2, 58-05-9, 73951-54-9 149436 6006
11
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 4112 126941
12
Dimercaprol Approved Phase 4 59-52-9 3080
13
Acyclovir Approved Phase 4 59277-89-3 2022
14
Valaciclovir Approved, Investigational Phase 4 124832-27-5, 124832-26-4 60773 135398742
15
Medroxyprogesterone acetate Approved, Investigational Phase 4 520-85-4, 71-58-9 6279 10631
16
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
17 HIV Protease Inhibitors Phase 4
18
protease inhibitors Phase 4
19 BB 1101 Phase 4
20 Immunologic Factors Phase 4
21 Vaccines Phase 4
22 beta-Lactams Phase 4
23 Lactams Phase 4
24 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
25 Gastrointestinal Agents Phase 4
26 Anti-Retroviral Agents Phase 4
27 Cathartics Phase 4
28 Laxatives Phase 4
29 Anti-HIV Agents Phase 4
30 Reverse Transcriptase Inhibitors Phase 4
31 Penicillins Phase 4
32 Gentamicins Phase 4
33 Folic Acid Antagonists Phase 4
34 Folate Phase 4
35 Vitamin B9 Phase 4
36 Vitamin B Complex Phase 4
37 Dermatologic Agents Phase 4
38 Immunoglobulins, Intravenous Phase 4
39 Neuromuscular Blocking Agents Phase 4
40
Aluminum hydroxide Approved, Investigational Phase 2, Phase 3 21645-51-2
41
Sertraline Approved Phase 3 79617-96-2 68617
42
Vancomycin Approved Phase 3 1404-90-6 14969
43
Hydroxocobalamin Approved Phase 2, Phase 3 13422-51-0 15589840 44475014
44
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2, Phase 3 1177-87-3 3680
45
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 3003 5743
46
Glycerin Approved, Investigational Phase 3 56-81-5 753
47
Meticillin Approved, Investigational Phase 3 61-32-5 6087
48
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
49
Sulfamethoxazole Approved Phase 3 723-46-6 5329
50
Zinc cation Approved, Experimental, Investigational Phase 3 7440-66-6, 23713-49-7 32051

Interventional clinical trials:

(show top 50) (show all 359)
# Name Status NCT ID Phase Drugs
1 Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis Without Acquired Immune Deficiency Syndrome Unknown status NCT02686853 Phase 4 Liposomal amphotericin B
2 Evaluation of Safety and Immunogenicity of Meningococcal B and Meningococcal ACWY Vaccine in at Risk Population (ProPositive Study) Unknown status NCT03682939 Phase 4
3 A Phase IV, Single Center, Open-Label, Controlled, Randomized Study to Evaluate the Memory Response of Children Previously Vaccinated With Chiron Meningococcal C Conjugate Vaccine, Menjugate® and Describe the Kinetic of the Antibody Response and Maturation on Days 2-7 and 28 After Challenge With Pasteur Merieux Meningococcal A/C Polysaccharide Vaccine or Menjugate® Unknown status NCT00262015 Phase 4
4 Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. A Multi-center Comparative Randomized Double-blind and Placebo-controlled Clinical Trial Unknown status NCT01478035 Phase 4 Phenytoin;placebo
5 The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Unknown status NCT02588196 Phase 4 Dexamethasone acetate
6 Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis, Especially of Pneumococcal Meningitis, in Angola. Completed NCT01540838 Phase 4 Infusion with paracetamol;Bolus without paracetamol
7 Persistence of Bactericidal Antibodies in Adults Who Received a Booster Dose of Menactra® Approximately Four Years Earlier Completed NCT02633787 Phase 4
8 Immunogenicity and Safety of Two-Dose Series of a Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine (SP284; Menactra®) in Japanese Healthy Adult Subjects Completed NCT02591290 Phase 4
9 A Phase III/IV Randomised Open-label Study and Comparison of the Immunogenicity and Safety of a Single Adolescent Booster Dose of a Meningococcal Group C Conjugate-containing Booster Vaccine (Meningitec™, OR NeisVac-C™ , OR Menitorix™), When Given Concurrently With an Acellular Pertussis-containing Booster Vaccine (Repevax™ or IPV-Boostrix™) Completed NCT02526394 Phase 4 Pertussis containing vaccine
10 Postmarketing Surveillance Study for Use of Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine (Menactra®) in the Republic of Korea Completed NCT02864927 Phase 4
11 Cluster-randomized Trial to Evaluate the Impact of Ciprofloxacin for Contacts of Cases of Meningococcal Meningitis as an Epidemic Response Completed NCT02724046 Phase 4 Ciprofloxacin
12 Trial for the Optimal Timing of HIV Therapy After Cryptococcal Meningitis Completed NCT01075152 Phase 4 efavirenz
13 A Randomized Clinical Trial of Immediate Versus Standard Antiretroviral Therapy for HIV-infected Adults Presenting With Cryptococcal Meningitis Completed NCT00976040 Phase 4
14 Assay of the Immunogenicity of Fractional Dose Tetravalent A, C, Y, W135 Meningococcal Polysaccharide Vaccine in Africa Completed NCT00271479 Phase 4
15 A Phase IV Randomized, Observer-blind, Controlled Study to Demonstrate Non-inferior Immunogenicity of Yuxi Walvax MPV ACYW® Vaccine as Compared to Sanofi Pasteur Menactra® Vaccine in Healthy Subjects Aged 2-10 Years Completed NCT04450498 Phase 4
16 An Open Randomised Trial of Ceftriaxone v Penicillin and Gentamicin in Infant Severe Sepsis and Bacterial Meningitis in Malawi Completed NCT01247909 Phase 4 Ceftriaxone v penicillin and gentamicin
17 A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of a Combined Tetanus, Reduced Diphtheria Toxoid, Acellular Pertussis Vaccine (Tdap, Boostrix®) and Quadrivalent Human Papillomavirus [Types 6, 11, 16, 18] Recombinant Vaccine (Gardasil®) in Healthy Adolescents When Administered With MenACWY Conjugate Vaccine Completed NCT01424644 Phase 4
18 Operational Research for Cryptococcal Antigen Screening to Improve ART Survival Completed NCT01535469 Phase 4 Fluconazole
19 A Sourcing Study to Collect Human Biological (Serum) Samples From Healthy Adults Completed NCT03493919 Phase 4
20 A Randomized Clinical Study to Determine the Patient Benefit and Safety of Depocyt (Cytarabine Liposome Injection) for the Treatment of Neoplastic Meningitis Completed NCT00029523 Phase 4 Intrathecal (injected into the spinal fluid) DepoCyt;Intrathecal methotrexate;Intrathecal cytarabine (also known as ara-C)
21 Therapeutic Monitoring of Ceftriaxone, Prescribed at High Doses, in the Treatment of Meningitis and Others Neurological Infections. Completed NCT01745679 Phase 4 Ceftriaxone treatment
22 A Randomised, Descriptive, Open Label, Study Exploring the Relationship Between Gene Expression Signatures With Reactogenicity and Immunogenicity Following Vaccination With Serogroup B Meningococcal Vaccine (4CMenB) Completed NCT02080559 Phase 4
23 Immunogenicity and Safety of Meningococcal (Groups A, C, Y, and W-135) Diphtheria Toxoid Conjugate Vaccine (Menactra®) in Adolescents in the US When Administered Concomitantly With Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed (Tdap Vaccine) Completed NCT00777257 Phase 4
24 Safety and Immunogenicity of Intradermal, and Low-dose Subcutaneous vs Subcutaneous Administration of Menomune® - A/C/Y/W-135 Completed NCT00850603 Phase 4
25 Open Label Study of Lung and Serum Immunoglobulin Responses to 7-Valent Pneumococcal Conjugate Vaccine in HIV Infected and Non-HIV Infected Malawian Adults Completed NCT00371878 Phase 4
26 An Immunogenicity and Safety Evaluation of Menactra® (Meningococcal [Groups A, C, Y and W-135] Polysaccharide Diphtheria Toxoid Conjugate Vaccine) When Administered to Healthy Subjects at 9 Months and Concomitantly With Pentacel® at 15 to 18 Months of Age. Completed NCT01659996 Phase 4
27 A Single Centre, Open-label, Randomised Clinical Study to Investigate Meningococcal Serogroup A and C Saccharide Specific B Cell Responses in Adult Volunteers to One of Three Regimens of Meningococcal ACWY Conjugate Vaccine or Meningococcal ACWY Polysaccharide Vaccine Priming Doses Followed by a Booster Dose of the Meningococcal ACWY Conjugate Vaccine Completed NCT01593514 Phase 4
28 The Impact of Vaccination With a Serogroup A Meningococcal Conjugate Vaccine on Carriage of Serogroup A Meningococci in Mali and Niger Completed NCT01119482 Phase 4
29 Evaluation of the Effect of Tetravalent (A, C, Y, W-135) Meningococcal Conjugate Vaccine on Serogroup-Specific Carriage of Neisseria Meningitidis Completed NCT00119080 Phase 4
30 Meningococcal (Groups A, C, Y, W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine (Menactra®) Post-Marketing Safety Study in Healthy Children (2-11 Years), Adolescents (12-17 Years) and Adults (18-55 Years) in the Philippines Completed NCT01270503 Phase 4
31 Safety and Immunogenicity of Sanofi Pasteur Meningococcal (Groups A and C) Polysaccharide Vaccine Versus Lanzhou Institute for Biological Products Meningococcal (Groups A and C) Polysaccharide Vaccine in Children 2-6 Years of Age in China Completed NCT01430611 Phase 4
32 Immunogenicity of Quadrivalent Meningococcal Conjugate Vaccine in Frequent Platelets Donors Active, not recruiting NCT04224311 Phase 4
33 Aciclovir for HSV-2 Meningitis: A Double-blind Randomised Controlled Trial (AMEN) Not yet recruiting NCT05452928 Phase 4 Acyclovir 50 MG/ML;Placebo
34 Mild Induced Hypothermia to Treat Severe Community Acquired Meningitis in Adults Admitted to Intensive Care Unit Terminated NCT00774631 Phase 4
35 Amikacin Penetration Into the Cerebrospinal Fluid: Pharmacokinetic/Pharmacodynamic Analysis in Adults With Hospital Acquired Gram-negative Meningitis Associated With Intracranial Pressure Monitoring and Draining Devices Withdrawn NCT00362245 Phase 4 Systemic and Intra-Thecal Amikacin Therapy
36 Cluster-randomized Trial to Evaluate the Impact of Ciprofloxacin Prophylaxis as a Response to a Meningococcal Meningitis Epidemic Withdrawn NCT03431675 Phase 4 Ciprofloxacin
37 Antifungal Treatment of Cryptococcal Meningitis Unknown status NCT04140461 Phase 3 Amphotericin B;Flucytosine
38 A Randomized, Double-Blind, Controlled, Non-inferiority Phase III Trial of a Group A Meningococcal Polysaccharide Vaccine in Healthy Infants Aged 6-15 Months Unknown status NCT04689165 Phase 3
39 A Randomized, Double-Blind, Controlled, Non-inferiority Phase III Trial of a Group A and C Meningococcal Polysaccharide Vaccine in Healthy Children Aged 2-6 Years Unknown status NCT04689191 Phase 3
40 Immunogenicity, Reactogenicity and Safety Assessment of the Meningococcal Serogroup C Vaccine Produced by Bio-Manguinhos / FIOCRUZ in Infants, Children and Adolescents Unknown status NCT02858570 Phase 2, Phase 3
41 Prospective Pilot Study to Evaluate a Standardized Management of Cryptococcal Meningitis in Patients Infected With HIV in Sub-Saharan Africa Involving an Initial Combination Therapy With Fluconazole and Flucytosine in High Doses, Complemented by Repeat Lumbar Punctures Unknown status NCT01715922 Phase 2, Phase 3 Fluconazole;Flucytosine
42 A Study of Safety and Immunogenicity of 10-valent and 13-valent Pneumococcal Conjugate Vaccines to Inform Policy Regarding Pneumococcal Vaccination of Papua New Guinean Children Unknown status NCT01619462 Phase 3
43 Rapid Diagnostic Tests in Association With Clinical and Laboratory Predictors for the Diagnosis of Neglected Tropical Diseases in Patients With Neurological Disorders in Rural Hospitals of Bandundu,Democratic Republic of Congo Completed NCT01589289 Phase 3
44 Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis Completed NCT01802385 Phase 3 Sertraline
45 Immunogenicity and Safety of a Booster Dose of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Adolescents and Adults Completed NCT02752906 Phase 3
46 Immunogenicity and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine Administered in Healthy Children 2 to 9 Years of Age Completed NCT03077438 Phase 3
47 Immunogenicity and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Toddlers 12 to 23 Months of Age. Completed NCT02955797 Phase 3
48 Immunogenicity and Safety of a Single Dose of a Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine (SP284) in Japanese Subjects Completed NCT01519713 Phase 3
49 Immunogenicity and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Adults Age 56 Years and Older Completed NCT02842866 Phase 3
50 Immune Lot Consistency, Immunogenicity, and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Adolescents and Adults Aged 10 to 55 Years Completed NCT02842853 Phase 3

Search NIH Clinical Center for Meningitis

Cochrane evidence based reviews: meningitis

Genetic Tests for Meningitis

Anatomical Context for Meningitis

Organs/tissues related to Meningitis:

MalaCards : Spinal Cord, Brain, Bone Marrow, Breast, Lung, Bone, Liver

Publications for Meningitis

Articles related to Meningitis:

(show top 50) (show all 31572)
# Title Authors PMID Year
1
Current state and practice variation in the use of Meningitis/Encephalitis (ME) FilmArray panel in children. 62 41
36316633 2022
2
Comparisons in the changes of clinical characteristics and cerebrospinal fluid cytokine profiles between varicella-zoster virus meningitis/encephalitis and other central nervous system infections. 62 41
36411685 2022
3
Hypervirulent carbapenem-resistant Klebsiella pneumoniae causing highly fatal meningitis in southeastern China. 62 41
36324461 2022
4
Comparative analysis of cerebrospinal fluid adenosine deaminase in tuberculous and non-tuberculous meningitis. 53 62
20399005 2010
5
Adenosine deaminase and tuberculous meningitis--a systematic review with meta-analysis. 53 62
20001225 2010
6
HLA-DRB1*01 allele and low plasma immunoglobulin G1 concentration may predispose to herpes-associated recurrent lymphocytic meningitis. 53 62
19879913 2010
7
Very late-onset group B Streptococcus meningitis, sepsis, and systemic shigellosis due to interleukin-1 receptor-associated kinase-4 deficiency. 53 62
19814626 2009
8
[A case of listeria meningitis showed high levels of adenosine deaminase in cerebrospinal fluid]. 53 62
19928691 2009
9
Bacterial meningitis: rapid diagnosis and microbial profile: a multicentered study. 53 62
19301695 2008
10
C-reactive protein as an indicator of aqueductal gliosis and hydrocephaly in neonatal meningitis. 53 62
18581011 2008
11
Comparative study of cerebrospinal fluid adenosine deaminase activity in patients with meningitis. 53 62
17899959 2007
12
A case of Listeria meningitis associated with increased adenosine deaminase in cerebrospinal fluid. 53 62
17141462 2007
13
Activin A concentrations in human cerebrospinal fluid are age-dependent and elevated in meningitis. 53 62
16920154 2006
14
Serum concentrations of interleukin-1 alpha, interleukin-6 and tumor necrosis factor-alpha in neonatal sepsis and meningitis. 53 62
17013473 2006
15
Expression of innate immune complement regulators on brain epithelial cells during human bacterial meningitis. 53 62
16948860 2006
16
Cerebrospinal fluid adenosine deaminase activity for the diagnosis of tuberculous meningitis in adults. 53 62
17333738 2006
17
Interleukin-1alpha, interleukin-6 and tumor necrosis factor-alpha levels in children with sepsis and meningitis. 53 62
16635168 2006
18
[Lymphocytis meningitis: Listeria monocytogenes is a potential risk in a immunocompetent child]. 53 62
16185855 2005
19
Shigella sonnei meningitis due to interleukin-1 receptor-associated kinase-4 deficiency: first association with a primary immune deficiency. 53 62
15825022 2005
20
Antibiotic susceptibility in relation to penicillin-binding protein genes and serotype distribution of Streptococcus pneumoniae strains responsible for meningitis in Japan, 1999 to 2002. 53 62
15105095 2004
21
[Concentration of proinflammatory cytokines (TNF-alpha, IL-8) in the cerebrospinal fluid and the course of bacterial meningitis]. 53 62
15230146 2004
22
Group B streptococcal beta-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis. 53 62
12952922 2003
23
Expression of matrix metalloproteinases, sICAM-1 and IL-8 in CSF from children with meningitis. 53 62
12480084 2003
24
Neurotrophin-4 and glial cell line-derived neurotrophic factor in cerebrospinal fluid from meningitis/encephalitis patients. 53 62
12213609 2002
25
Interleukin-8 levels in children with bacterial, tuberculous and aseptic meningitis. 53 62
12003295 2002
26
Worldwide variation in the incidence of Haemophilus influenzae type b meningitis and its association with ampicillin resistance. 53 62
11939404 2002
27
[Does the estimation of acute phase protein concentrations in cerebrospinal fluid and/or in serum in patients with viral meningitis carry diagnostic importance? Part I. Lymphocytic meningitis caused by epidemic parotitis]. 53 62
12666587 2002
28
The possible role of cerebrospinal fluid adenosine deaminase activity in the diagnosis of tuberculous meningitis in adults. 53 62
11792470 2002
29
Complement factor I deficiency associated with recurrent meningitis coinciding with menstruation. 53 62
11709004 2001
30
[Chemokines in meningitis of different etiologies]. 53 62
11320578 2001
31
Levels of three inflammation markers, C-reactive protein, serum amyloid A protein and procalcitonin, in the serum and cerebrospinal fluid of patients with meningitis. 53 62
11763415 2001
32
Follistatin (FS) in human cerebrospinal fluid and regulation of FS expression in a mouse model of meningitis. 53 62
11124865 2000
33
Adenosine deaminase levels in cerebrospinal fluid and serum in the diagnosis of tubercular meningitis. 53 62
11191154 2000
34
Systemic neutralization of interleukin-8 markedly reduces neutrophilic pleocytosis during experimental lipopolysaccharide-induced meningitis in rabbits. 53 62
10992482 2000
35
[Serial measurement of anti-interleukin-8 IgG autoantibody in cerebrospinal fluid of infants with bacterial meningitis]. 53 62
11109762 2000
36
Serum C-reactive protein in the differential diagnosis of childhood meningitis. 53 62
11059546 2000
37
Fc gamma receptor allotypes in children with bacterial meningitis. A preliminary study. 53 62
10028861 1998
38
[Quantitative levels of serum amyloid A protein and other proteins in cerebrospinal fluid and serum of patients with meningitis]. 53 62
9800479 1998
39
The production of macrophage inflammatory protein-1alpha in the cerebrospinal fluid at the initial stage of meningitis in children. 53 62
9396559 1997
40
[Bacterial meningitis and CSF cytokines]. 53 62
15034315 1997
41
[Evaluation of tumor necrosis factor and C-reactive protein level determination in cerebrospinal fluid of meningitis and encephalitis]. 53 62
9424322 1997
42
[Detection of Neisseria meningitidis group B antigens by MB-Dot-Elisa test in patients with meningitis]. 53 62
9162589 1997
43
[Nitric oxide, TNF-alpha and IL-8 in cerebrospinal fluids of tuberculous and cryptococcic meningitis]. 53 62
10072993 1997
44
Detection of N. meningitidis group B antigens by MB-Dot-ELISA in patients with meningitis. 53 62
8897721 1996
45
Chemokines in the cerebrospinal fluid of patients with meningitis. 53 62
8764560 1996
46
Interleukin-8 in cerebrospinal fluid from patients with septic and aseptic meningitis. 53 62
8801091 1996
47
The use of adenosine deaminase activity as a biochemical marker for the diagnosis of tuberculous meningitis. 53 62
8935128 1995
48
Interleukin-8 in cerebrospinal fluid from patients with meningitis of different etiologies: its possible role as neutrophil chemotactic factor. 53 62
7622911 1995
49
Adenosine deaminase in cerebrospinal fluid during brucella meningitis. 53 62
8522847 1995
50
Adenosine deaminase activity in the CSF of patients with aseptic meningitis: utility in the diagnosis of tuberculous meningitis or neurobrucellosis. 53 62
7756471 1995

Variations for Meningitis

Expression for Meningitis

Search GEO for disease gene expression data for Meningitis.

Pathways for Meningitis

Pathways related to Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 CCL2 CCL4 CXCL1 CXCL8 IL10 IL1B
2
Show member pathways
13.8 CCL2 CCL4 CD46 CFI CFP CRP
3
Show member pathways
13.69 TNF IL6 IL1B IL10 IFNG CXCL8
4
Show member pathways
13.58 TNF IL6 IL1B IL10 IFNG CXCL8
5
Show member pathways
13.52 TNF TLR2 IRAK4 IL6 IL1B IL10
6
Show member pathways
13.41 CCL2 CCL4 CXCL1 CXCL8 IFNG IL10
7
Show member pathways
13.39 TNF IL6 IL1B IL10 CXCL8 CXCL1
8
Show member pathways
12.91 TNF TLR2 MBL2 IRAK4 IL6 IL1B
9 12.8 IL6 IL1B IL10 CXCL1 CCL4 CCL2
10
Show member pathways
12.76 TNF TLR2 IRAK4 IL6 IL1B
11
Show member pathways
12.73 CXCL8 IL1B IL6 IRAK4 TLR2 TNF
12
Show member pathways
12.72 TNF IL6 IL1B IL10 IFNG CXCL1
13
Show member pathways
12.71 TNF IL6 IL1B IL10 IFNG CXCL8
14
Show member pathways
12.69 ALB CD46 CFI CFP CRP IFNG
15
Show member pathways
12.66 TNF TLR2 IRAK4 IL6 IL1B CXCL8
16 12.63 TNF TLR2 IRAK4 IL1B IL10 IFNG
17
Show member pathways
12.52 CXCL8 IFNG IL1B IL6 IRAK4 TLR2
18
Show member pathways
12.46 CXCL8 IFNG IL1B IL6 IRAK4 TNF
19
Show member pathways
12.42 TNF TLR2 IL6 CXCL8 CXCL1 CCL2
20 12.3 TNF IL6 IL1B IL10 CXCL8
21 12.25 TNF TLR2 IL6 IFNG
22 12.24 TNF IL6 IL1B IL10 IFNG
23
Show member pathways
12.13 CXCL8 CXCL1 CCL4 CCL2
24
Show member pathways
12.11 MBL2 CRP CFP CFI CD46
25 12.09 IFNG IL10 IL6 TNF
26
Show member pathways
12.09 MBL2 CRP CFP CD46
27 12.09 CXCL1 CXCL8 IFNG IL1B IL6
28 12.07 TNF IL6 IL1B IL10 CXCL8 CCL2
29 12.02 TNF IL1B IL10 IFNG CXCL8
30
Show member pathways
12.02 TNF TLR2 IL6 IL1B IL10 IFNG
31 12.01 CCL2 CXCL1 CXCL8 IFNG IL1B IL6
32 12 IL6 IL10 CXCL8 CCL2
33
Show member pathways
11.98 TLR2 IL6 IL1B IFNG
34 11.92 TNF IL1B IL10 IFNG
35 11.9 TNF IL6 IL1B IL10 IFNG
36
Show member pathways
11.89 IL6 CXCL8 CRP CCL2
37 11.87 TNF IL6 IL10 IFNG CRP
38 11.85 IL6 IL10 IFNG CXCL8 CCL2
39
Show member pathways
11.83 TNF IL1B IFNG
40 11.83 TNF IL6 IL1B CXCL8 CXCL1 CCL2
41 11.81 IL6 IFNG CXCL8
42 11.8 IL6 IL10 IFNG
43
Show member pathways
11.8 TNF IL6 IL1B IFNG CXCL8
44 11.79 TNF IRAK4 IL6 IL1B IL10
45 11.76 IL6 IL1B IFNG
46
Show member pathways
11.76 TNF TLR2 IL6 IL10 IFNG
47
Show member pathways
11.75 TNF IFNG CXCL8
48 11.73 TNF IL6 IL1B CXCL8 CCL4 CCL2
49 11.7 TNF IRAK4 IL6 IL10 CXCL8 CCL4
50 11.69 TNF IL6 IFNG CXCL8 CCL2

GO Terms for Meningitis

Cellular components related to Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.13 ALB CCL2 CCL4 CFI CFP CRP
2 extracellular space GO:0005615 9.83 ALB CCL2 CCL4 CFI CFP CRP

Biological processes related to Meningitis according to GeneCards Suite gene sharing:

(show all 50)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.6 TNF TLR2 IRAK4 IL6 IL1B IL10
2 innate immune response GO:0045087 10.48 TLR2 MBL2 IRAK4 CRP CFP CFI
3 negative regulation of cell population proliferation GO:0008285 10.38 CXCL1 CXCL8 IL10 IL1B IL6 TLR2
4 positive regulation of gene expression GO:0010628 10.36 CD46 CRP CXCL8 IFNG IL1B IL6
5 defense response to bacterium GO:0042742 10.34 TNF MBL2 LYZ IL10 CFP
6 positive regulation of DNA-binding transcription factor activity GO:0051091 10.29 TNF IL6 IL1B IL10
7 positive regulation of inflammatory response GO:0050729 10.28 TNF TLR2 IL1B IFNG
8 cellular response to type II interferon GO:0071346 10.26 TNF TLR2 CCL4 CCL2
9 chemokine-mediated signaling pathway GO:0070098 10.24 CCL2 CCL4 CXCL1 CXCL8
10 positive regulation of interleukin-8 production GO:0032757 10.21 TNF TLR2 IL6 IL1B
11 humoral immune response GO:0006959 10.2 CCL2 IFNG IL6 TNF
12 positive regulation of nitric oxide biosynthetic process GO:0045429 10.18 TNF IL1B IFNG
13 positive regulation of interleukin-10 production GO:0032733 10.18 TLR2 IL6 CD46
14 positive regulation of cytokine production GO:0001819 10.18 TNF IL1B IL10 IFNG
15 positive regulation of interleukin-6 production GO:0032755 10.18 TNF TLR2 IL6 IL1B IFNG
16 immune system process GO:0002376 10.17 TLR2 MBL2 IRAK4 CFP CFI CD46
17 acute-phase response GO:0006953 10.17 MBL2 IL6 CRP
18 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.16 IL10 IL6 TNF
19 liver regeneration GO:0097421 10.15 TNF IL6 IL10
20 regulation of insulin secretion GO:0050796 10.15 IFNG IL1B IL6 TNF
21 microglial cell activation GO:0001774 10.14 TNF TLR2 IFNG
22 negative regulation of neurogenesis GO:0050768 10.13 TNF IL6 IL1B
23 positive regulation of glial cell proliferation GO:0060252 10.1 TNF IL6 IL1B
24 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 10.1 TLR2 IFNG CCL2
25 positive regulation of phagocytosis GO:0050766 10.1 TNF MBL2 IL1B IFNG
26 lipopolysaccharide-mediated signaling pathway GO:0031663 10.1 CCL2 IL1B TLR2 TNF
27 neutrophil chemotaxis GO:0030593 10.1 CCL2 CCL4 CXCL1 CXCL8 IL1B
28 embryonic digestive tract development GO:0048566 10.09 ADA CXCL8 TNF
29 positive regulation of membrane protein ectodomain proteolysis GO:0051044 10.08 TNF IL1B IFNG
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 10.07 TNF IL1B IL10
31 cellular response to lipopolysaccharide GO:0071222 10.07 CCL2 CXCL1 CXCL8 IL10 IL1B IL6
32 astrocyte activation GO:0048143 10.06 TNF IL1B IFNG
33 positive regulation of NMDA glutamate receptor activity GO:1904783 10.01 IFNG CCL2
34 negative regulation of cytokine production involved in immune response GO:0002719 10.01 TNF IL10
35 positive regulation of fever generation GO:0031622 10 IL1B TNF
36 positive regulation of neuroinflammatory response GO:0150078 10 TNF IL6 IL1B
37 defense response to Gram-positive bacterium GO:0050830 10 TNF TLR2 MBL2 LYZ IL6 IL1B
38 sequestering of triglyceride GO:0030730 9.99 TNF IL1B
39 negative regulation of lipid storage GO:0010888 9.99 TNF IL6 CRP
40 leukocyte migration GO:0050900 9.98 ADA IL1B TNF
41 positive regulation of nitrogen compound metabolic process GO:0051173 9.97 IFNG TNF
42 positive regulation of chemokine production GO:0032722 9.97 TNF TLR2 IL6 IL1B IFNG
43 inflammatory response GO:0006954 9.96 CCL2 CCL4 CRP CXCL1 CXCL8 IL1B
44 chronic inflammatory response to antigenic stimulus GO:0002439 9.95 IL10 TNF
45 positive regulation of vitamin D biosynthetic process GO:0060557 9.95 IFNG TNF
46 response to molecule of bacterial origin GO:0002237 9.93 TLR2 IL10 CXCL8
47 vascular endothelial growth factor production GO:0010573 9.91 TNF IL6 IL1B
48 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.85 TNF IL1B IFNG
49 response to external stimulus GO:0009605 9.75 TLR2 CXCL8 CXCL1
50 immune response GO:0006955 9.5 TNF TLR2 IL6 IL1B IL10 IFNG

Molecular functions related to Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.56 CXCL8 CXCL1 CCL4 CCL2
2 cytokine activity GO:0005125 9.5 TNF IL6 IL1B IL10 IFNG CXCL8

Sources for Meningitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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