MCID: MNN013
MIFTS: 69

Meningitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Meningitis

Summaries for Meningitis

NINDS : 55 Meningitis is an infection of the meninges, the membranes that surround the brain and spinal cord. Encephalitis is inflammation of the brain itself. Anyone can get encephalitis or meningitis. Causes of encephalitis and meningitis include viruses, bacteria, fungus, and parasites. Anyone experiencing symptoms of meningitis or encephalitis should see a doctor immediately. Symptoms of encephalitis that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia. Other symptoms include: sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, irritability. In more severe cases, people may have problems with speech or hearing, vision problems, and hallucinations. Symptoms of meningitis, which may appear suddenly, often include: high fever, severe and persistent headache, stiff neck, nausea, sensitivity to bright light, vomiting, and changes in behavior such as confusion, sleepiness, and difficulty waking up. In infants, symptoms of meningitis or encephalitis may include fever, vomiting, lethargy, body stiffness, unexplained irritability, and a full or bulging fontanel (the soft spot on the top of the head).

MalaCards based summary : Meningitis is related to viral meningitis and aseptic meningitis, and has symptoms including seizures, tremor and fever. An important gene associated with Meningitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Phenytoin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spinal cord, and related phenotypes are homeostasis/metabolism and immune system

Disease Ontology : 12 A central nervous system disease that is characterized by an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells.

MedlinePlus : 44 Meningitis is inflammation of the thin tissue that surrounds the brain and spinal cord, called the meninges. There are several types of meningitis. The most common is viral meningitis. You get it when a virus enters the body through the nose or mouth and travels to the brain. Bacterial meningitis is rare, but can be deadly. It usually starts with bacteria that cause a cold-like infection. It can cause stroke, hearing loss, and brain damage. It can also harm other organs. Pneumococcal infections and meningococcal infections are the most common causes of bacterial meningitis. Anyone can get meningitis, but it is more common in people with weak immune systems. Meningitis can get serious very quickly. You should get medical care right away if you have A sudden high fever A severe headache A stiff neck Nausea or vomiting Early treatment can help prevent serious problems, including death. Tests to diagnose meningitis include blood tests, imaging tests, and a spinal tap to test cerebrospinal fluid. Antibiotics can treat bacterial meningitis. Antiviral medicines may help some types of viral meningitis. Other medicines can help treat symptoms. There are vaccines to prevent some of the bacterial infections that cause meningitis. NIH: National Institute of Neurological Disorders and Stroke

CDC : 3 Meningitis is an inflammation (swelling) of the protective membranes covering the brain and spinal cord. A bacterial or viral infection of the fluid surrounding the brain and spinal cord usually causes the swelling. However, injuries, cancer, certain drugs, and other types of infections also can cause meningitis. It is important to know the specific cause of meningitis because the treatment differs depending on the cause.

Wikipedia : 77 Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord,... more...

Related Diseases for Meningitis

Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1324)
# Related Disease Score Top Affiliating Genes
1 viral meningitis 34.5 CRP CXCL8 IFNG IL6
2 aseptic meningitis 34.4 CXCL8 IFNG IL10 IL1B NLRP3 TNF
3 cryptococcal meningitis 34.2 ADA IFNG MBL2
4 chronic meningitis 34.1 CRP MMP9 NLRP3
5 streptococcal meningitis 34.0 CFP CRP MBL2 TNF
6 tuberculous meningitis 33.9 ADA CXCL8 LYZ MMP9 TLR2 TNF
7 pneumococcal meningitis 33.8 IRAK4 MMP9
8 bacterial meningitis 33.2 ALB CFP CRP CXCL8 IL10 IL1B
9 listeriosis 33.0 IL6 MBL2 TNF
10 neurosyphilis 32.9 CXCL8 IL10 TLR2
11 meningococcemia 32.5 CFP IL1B MBL2
12 extrapulmonary tuberculosis 32.1 ADA IFNG IL10 IL1B TLR2
13 neisseria meningitidis infection 32.1 CFP LACTB MBL2 TLR2
14 cerebral palsy 31.7 IL1B IL6 MBL2 TNF
15 leptospirosis 31.7 CRP CXCL8 IFNG IL10 IL1B IL6
16 behcet syndrome 31.7 ADA CRP CXCL8 IFNG IL10 IL1B
17 tuberculous peritonitis 31.6 ADA ALB CRP IFNG TNF
18 haemophilus influenzae 31.5 CXCL8 IL1B TLR2 TNF
19 miliary tuberculosis 31.0 ADA IFNG TNF
20 poliomyelitis 30.8 IFNG IL10 TNF
21 neuritis 30.7 IFNG IL1B TNF
22 relapsing polychondritis 30.6 CRP IFNG IL6
23 purpura 30.6 CRP IL6 TNF
24 scrub typhus 30.5 CRP IL10 IL1B TLR2 TNF
25 acquired immunodeficiency syndrome 30.5 ALB IFNG IL10 IL1B IL6 TNF
26 candidiasis 30.5 IFNG IL10 MBL2
27 connective tissue disease 30.5 IFNG IL10 IL6 TNF
28 exanthem 30.5 CRP IL6 NLRP3 TNF
29 suppurative otitis media 30.5 CRP IL1B TLR2
30 arthritis 30.4 CXCL8 IFNG IL10 IL1B IL6 MMP9
31 brain edema 30.4 ALB IL1B IL6 MMP9
32 uveitis 30.4 IFNG IL10 TNF
33 mixed connective tissue disease 30.4 IFNG IL10 IL6 TNF
34 infective endocarditis 30.4 CRP IL6 TLR2 TNF
35 septic arthritis 30.4 CRP CXCL8 TLR2
36 adult-onset still's disease 30.4 CRP IL1B IL6 TNF
37 lymphadenitis 30.4 CXCL8 IFNG IL10 IL1B TNF
38 familial mediterranean fever 30.4 CRP IL1B NLRP3 TNF
39 mycobacterium fortuitum 30.4 CXCL8 LACTB
40 transverse myelitis 30.4 CXCL8 IL10 IL6 MMP9 TNF
41 multiple sclerosis 30.3 IFNG IL10 IL1B IL6 MMP9 PTGDS
42 radiculopathy 30.3 CXCL8 IL10 IL6
43 osteomyelitis 30.3 CXCL8 IFNG IL10 IL1B IL6 TNF
44 viral encephalitis 30.3 CXCL8 IL10 IL1B IL6 TNF
45 human immunodeficiency virus infectious disease 30.3 CCL4 IFNG IL10 IL6 TNF
46 spotted fever 30.3 IFNG IL10 TNF
47 conjunctivitis 30.3 CXCL8 IFNG IL6 NLRP3
48 myeloma, multiple 30.3 ALB CRP CXCL8 IL6 TNF
49 cystitis 30.2 CRP CXCL8 IL6 TNF
50 endocarditis 30.2 ALB CRP CXCL8 IL10 IL6 LACTB

Comorbidity relations with Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis Chronic Meningitis
Deficiency Anemia Hypertension, Essential

Graphical network of the top 20 diseases related to Meningitis:



Diseases related to Meningitis

Symptoms & Phenotypes for Meningitis

UMLS symptoms related to Meningitis:


seizures, tremor, fever, pruritus, back pain, pain, headache, hemiplegia, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness, meningism, hyperexplexia

MGI Mouse Phenotypes related to Meningitis:

47 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.38 ADA ALB CFP CRP IFNG IL10
2 immune system MP:0005387 10.33 ADA CFP CRP IFNG IL10 IL1B
3 hematopoietic system MP:0005397 10.31 ADA IFNG IL10 IL1B IL6 IRAK4
4 cardiovascular system MP:0005385 10.29 ADA CFP CRP IFNG IL10 IL1B
5 cellular MP:0005384 10.28 ADA ALB IFNG IL10 IL6 IRAK4
6 digestive/alimentary MP:0005381 10.22 ADA ALB IFNG IL10 IL6 LYZ
7 mortality/aging MP:0010768 10.18 ADA ALB CFP IFNG IL10 IL1B
8 endocrine/exocrine gland MP:0005379 10.16 ADA ALB IFNG IL10 IL6 LYZ
9 integument MP:0010771 10.13 IFNG IL10 IL1B IL6 LYZ MMP9
10 liver/biliary system MP:0005370 10.06 ADA ALB IFNG IL10 IL6 LYZ
11 neoplasm MP:0002006 9.96 ALB IFNG IL10 IL1B IL6 LYZ
12 muscle MP:0005369 9.92 ADA ALB IFNG IL10 IL6 MMP9
13 renal/urinary system MP:0005367 9.81 ADA ALB IFNG IL6 LYZ MBL2
14 respiratory system MP:0005388 9.56 ADA IFNG IL10 IL6 LYZ MMP9
15 skeleton MP:0005390 9.4 ADA CFP IFNG IL10 IL1B IL6

Drugs & Therapeutics for Meningitis

Drugs for Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 424)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 22916-47-8 4189
3
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1397-89-3 5280965 14956
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 1177-87-3
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-02-2 5743
6
Lamivudine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 134678-17-4 60825
7
Zidovudine Approved Phase 4,Not Applicable 30516-87-1 35370
8
Efavirenz Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 154598-52-4 64139
9
Cytarabine Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 147-94-4, 65-46-3 6253
10
Methotrexate Approved Phase 4,Phase 2 1959-05-2, 59-05-2 126941
11
Fluconazole Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 86386-73-4 3365
12
Ciprofloxacin Approved, Investigational Phase 4,Early Phase 1,Not Applicable 85721-33-1 2764
13
Ceftriaxone Approved Phase 4,Phase 3,Phase 1,Not Applicable 73384-59-5 5479530 5361919
14
Cefotaxime Approved Phase 4,Phase 2 63527-52-6 5742673 456256
15
Cefoxitin Approved Phase 4,Phase 2 35607-66-0 441199
16
Acetaminophen Approved Phase 4,Phase 3,Not Applicable 103-90-2 1983
17
Stavudine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 3056-17-5 18283
18
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 143 6006
19
Sodium Citrate Approved, Investigational Phase 4,Phase 2 68-04-2
20
Azathioprine Approved Phase 4 446-86-6 2265
21
Tetracycline Approved, Vet_approved Phase 4,Phase 3 60-54-8 5353990
22
Cosyntropin Approved Phase 4 16960-16-0 16129617
23
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
24
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
25
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613
26
Azithromycin Approved Phase 4,Phase 3 83905-01-5 447043 55185
27
Isoniazid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 54-85-3 3767
28
Nevirapine Approved Phase 4,Phase 2,Phase 3,Not Applicable 129618-40-2 4463
29
Ampicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 69-53-4 6249
30
Amikacin Approved, Investigational, Vet_approved Phase 4 37517-28-5 37768
31
Tenofovir Approved, Experimental, Investigational Phase 4 147127-20-6 464205
32
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 59-30-3 6037
33
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 77-92-9 311
34
Glycine Approved, Nutraceutical, Vet_approved Phase 4 56-40-6 750
35
Lactitol Investigational Phase 4,Phase 2,Phase 3 585-88-6, 585-86-4 493591
36
BCG vaccine Investigational Phase 4,Phase 2
37 Anticonvulsants Phase 4
38 Sodium Channel Blockers Phase 4,Not Applicable
39 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
40 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
41 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
42 Diuretics, Potassium Sparing Phase 4,Not Applicable
43 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Liposomal amphotericin B Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Antifungal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
47 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
48 BB 1101 Phase 4,Phase 2,Phase 3,Phase 1
49 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 593)
# Name Status NCT ID Phase Drugs
1 Study on the Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. Unknown status NCT01478035 Phase 4 Phenytoin;placebo
2 Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis Unknown status NCT02686853 Phase 4 Liposomal amphotericin B
3 The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Unknown status NCT02588196 Phase 4 Dexamethasone acetate
4 Kinetic of Immune Memory Response After Re-Vaccination With Meningococcal Vaccine Unknown status NCT00262015 Phase 4
5 Duration of Antibiotic Therapy in Community - Acquired Pneumonia Unknown status NCT01492387 Phase 4
6 Ciprofloxacin for the Prevention of Meningococcal Meningitis Completed NCT02724046 Phase 4 Ciprofloxacin
7 Infant Severe Sepsis and Bacterial Meningitis in Malawi Completed NCT01247909 Phase 4 Ceftriaxone v penicillin and gentamicin
8 Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis Completed NCT01540838 Phase 4 Infusion with paracetamol;Bolus without paracetamol
9 Optimal Time to Start Antiretroviral Therapy in HIV-infected Adults With Cryptococcal Meningitis Completed NCT00976040 Phase 4
10 Cryptococcal Optimal ART Timing Trial Completed NCT01075152 Phase 4 efavirenz
11 Pharmacological Study of High Doses of Ceftriaxone in Meningitidis Completed NCT01745679 Phase 4 Ceftriaxone treatment
12 Understanding the Immune Response to Two Different Meningitis Vaccines Completed NCT01593514 Phase 4
13 DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor Completed NCT00029523 Phase 4 Intrathecal (injected into the spinal fluid) DepoCyt;Intrathecal methotrexate;Intrathecal cytarabine (also known as ara-C)
14 Pertussis and Meningitis C Concomitant Vaccination in Adolescents Completed NCT02526394 Phase 4 Pertussis containing vaccine
15 Study on the Impact of Vaccination With a Conjugate Vaccine on Meningococcal Carriage Completed NCT01119482 Phase 4
16 A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents Completed NCT01424644 Phase 4
17 Post-Marketing Safety Study of Menactra® in Healthy Children, Adolescents, and Adults in the Philippines Completed NCT01270503 Phase 4
18 Investigating the Immune Response to 4CMenB in Infants Completed NCT02080559 Phase 4
19 Safety and Immunogenicity of Intradermal Versus Subcutaneous Doses of Menomune® Completed NCT00850603 Phase 4
20 Persistence of Bactericidal Antibodies in Adults Who Received a Booster Dose of Menactra® Approximately 4 Years Earlier Completed NCT02633787 Phase 4
21 Effect of Meningococcal Conjugate Vaccine on Meningococcal Carriage Completed NCT00119080 Phase 4
22 Study of Sanofi Pasteur and Lanzhou Institute's Meningococcal (Group A and C) Polysaccharide Vaccine in Children Completed NCT01430611 Phase 4
23 Immunogenicity and Safety of Two-Dose Series of Menactra® in Japanese Healthy Adult Subjects Completed NCT02591290 Phase 4
24 Operational Research for Cryptococcal Antigen Screening Completed NCT01535469 Phase 4 Fluconazole
25 Fractional Dose Tetravalent A, C, Y, W135 Meningococcal Polysaccharide Vaccine Completed NCT00271479 Phase 4
26 Immune Response to Rotavirus Vaccine After a Supplemental Dose Given at 9 Months of Age With Local EPI Vaccines in Mali Completed NCT02286895 Phase 4
27 Persistence of Immunogenicity of MenACWY Conjugate Vaccine 5 Years After Childhood Vaccination, and Immune Response to a Booster Dose Completed NCT01823536 Phase 4
28 A Phase IV Study to Evaluate the Immunogenicity and Safety in UK Laboratory Workers of Menitorix Completed NCT00503165 Phase 4
29 Immunogenicity of 7-Valent Pneumococcal Conjugate Vaccine in Lung Fluid of Adults With and Without HIV Infection Completed NCT00371878 Phase 4
30 Study of Menactra® in US Adolescents When Administered Concomitantly With Tdap Vaccine Completed NCT00777257 Phase 4
31 Study of Evaluating Safety and Immunogenicity of 23-Valent Pneumococcal Polysaccharide Vaccine With Influenza Vaccine in Children and Adults Completed NCT02062281 Phase 4
32 Study of Menactra® in Healthy Subjects at 9 Months and Concomitantly With Pentacel® at 15 to 18 Months of Age Completed NCT01659996 Phase 4
33 Immunogenicity of 13-valent Pneumococcal Conjugate Vaccine Compared to the Pneumococcal Polysaccharide Vaccine in Adult Kidney and Liver Transplant Patients Completed NCT01781871 Phase 4
34 Pneumococcal Vaccination of Crohn Patients Completed NCT01947010 Phase 4
35 Protection Against Pneumococcal Infection in Children With T1DM Completed NCT01939522 Phase 4
36 The Effect of Live Attenuated Inactivated Influenza Vaccine on Experimental Human Pneumococcal Carriage Study Completed NCT03502291 Phase 4
37 Induction of Immunity Against Streptococcus Pneumoniae in Adults With Inflammatory Bowel Disease Completed NCT01908283 Phase 4
38 A Study of the Interaction Between BCG And MenC Immunisation: BAM Completed NCT02002156 Phase 4
39 A Trial Comparing Two Pertussis-containing Vaccines in Pregnancy and Vaccine Responses in UK Mothers and Their Infants Completed NCT02145624 Phase 4 Repevax;Boostrix-IPV
40 Immunogenicity of 3+1 Versus 2+1 Schedule for PCV7 Completed NCT02040402 Phase 4
41 Cosyntropin Versus Epidural Blood Patch (EBP) for Treatment of Treatment of Post Dural Puncture Headache Completed NCT02394457 Phase 4 Cosyntropin
42 Study Evaluating the Safety and Ability to Produce Immune Response of Prevenar and Meningitec Given at the Same Time Completed NCT00581035 Phase 4
43 Safety and Efficacy Study of Flebogamma 5% DIF IGIV in Pediatric Subjects Completed NCT00634569 Phase 4
44 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Completed NCT03226119 Phase 4
45 Evaluation of Meningococcal C Vaccine Programmes in Canadian Children Completed NCT00936962 Phase 4
46 Determination of Gentamicin Dosing in Neonatal Patients Completed NCT00198601 Phase 4 Gentamicin in Uniject Pre-filled syringe
47 Persistence of Antibody Response to N. Meningitidis Group C in Children Completed NCT00316654 Phase 4
48 Kinetics of B Cell Response in Infants Menjugate Vaccination Completed NCT00310700 Phase 4
49 Persistence of Immune Response After Vaccination With MCC Completed NCT00310687 Phase 4
50 Persistence of Antibodies and Kinetics of B Cell Response in Healthy Children After Vaccination With MCC Vaccine Completed NCT00310713 Phase 4

Search NIH Clinical Center for Meningitis

Cochrane evidence based reviews: meningitis

Genetic Tests for Meningitis

Anatomical Context for Meningitis

MalaCards organs/tissues related to Meningitis:

42
Brain, Testes, Spinal Cord, Pituitary, Liver, Lung, T Cells

Publications for Meningitis

Articles related to Meningitis:

(show top 50) (show all 12503)
# Title Authors Year
1
A case of acute posterior multifocal placoid pigment epitheliopathy with aseptic meningitis and cerebral infarction. ( 30928157 )
2019
2
Rheumatoid arthritis presenting as rheumatoid meningitis. ( 30635304 )
2019
3
Combined testing for herpes simplex virus and Mycobacterium tuberculosis DNA in cerebrospinal fluid of patients with aseptic meningitis in Burkina Faso, West Africa. ( 30474140 )
2019
4
Aseptic meningitis as onset of Kawasaki disease. ( 30654606 )
2019
5
Viral (aseptic) meningitis: A review. ( 30731305 )
2019
6
Zika Virus-Associated Aseptic Meningitis and Guillain-Barre Syndrome in a Traveler Returning from Latin America: a Case Report and Mini-Review. ( 30767073 )
2019
7
Atypical spinal endodermal cyst presenting with contralateral C2 neuralgia and aseptic meningitis. ( 30847014 )
2019
8
Intrathecal Trastuzumab as a Potential Cause of Drug-Induced Aseptic Meningitis. ( 30905325 )
2019
9
The missing link between familial Mediterranean fever and recurrent aseptic meningitis. ( 30954407 )
2019
10
Outbreak of aseptic meningitis caused by echovirus 30 in Kushiro, Japan in 2017. ( 31082730 )
2019
11
MOG antibody seropositive aseptic meningitis: A new clinical phenotype. ( 31108402 )
2019
12
Acute aseptic meningitis during isotretinoin treatment for nodular acne solely presenting with headache: case report and brief review of the literature. ( 30160569 )
2019
13
Polymicrobial Anaerobic Meningitis Caused By Bacteroides Fragilis, Bacteroides Thetaiotaomicron, Fusobacterium Necrophorum And Slackia Exigua In A Patient With Mastoiditis Following Otitis Media. ( 30772448 )
2019
14
Plurihormonal Pit-1 lineage adenoma presenting as meningitis with recurrence after somatostatin analogue. ( 30897548 )
2019
15
Novel Mutation in GALT Gene in Galactosemia Patient with Group B Streptococcus Meningitis and Acute Liver Failure. ( 30987402 )
2019
16
Patterns of cerebral tissue oxygen tension and cytoplasmic redox state in bacterial meningitis. ( 30328110 )
2019
17
Diagnostic Value of Procalcitonin for Bacterial Meningitis in Children: A Comparison Analysis Between Serum and Cerebrospinal Fluid Procalcitonin Levels. ( 30371098 )
2019
18
Clinical Features of and Risk Factors for Hydrocephalus in Childhood Bacterial Meningitis. ( 30373442 )
2019
19
Nuchal Rigidity in Infantile Bacterial Meningitis. ( 30384970 )
2019
20
Outcomes of adjunctive steroid therapy in adult patients with bacterial meningitis in Taiwan: A nationwide population-based epidemiologic study. ( 30467052 )
2019
21
Managing the risk of bacterial meningitis among healthcare workers. ( 30496490 )
2019
22
Vancomycin Should Be Part of Empiric Therapy for Suspected Bacterial Meningitis. ( 30496558 )
2019
23
Not So Novel Complication of Adjunctive Steroids in Patients With Bacterial Meningitis. ( 30653071 )
2019
24
Diagnosis of bacterial meningitis in Ghana: Polymerase chain reaction versus latex agglutination methods. ( 30653582 )
2019
25
Cerebrospinal fluid procalcitonin predicts Gram-negative bacterial meningitis in patients with empiric antibiotic pretreatment. ( 30674333 )
2019
26
MiR-301a-3p in the pathogenesis of bacterial meningitis by targeting Cx43. ( 30703072 )
2019
27
MicroRNA-135a participates in the development of astrocytes derived from bacterial meningitis by downregulating HIF-1α. ( 30726113 )
2019
28
Comparing Single vs. Combined Cerebrospinal Fluid Parameters for Diagnosing Full-Term Neonatal Bacterial Meningitis. ( 30728800 )
2019
29
Multiplex-PCR for diagnosis of bacterial meningitis. ( 30796713 )
2019
30
Cerebrospinal fluid/blood glucose point-of-care testing ratio for diagnosing bacterial meningitis in a limited medical resource setting. ( 30801430 )
2019
31
Etiology and Clinical Features of Full-Term Neonatal Bacterial Meningitis: A Multicenter Retrospective Cohort Study. ( 30815433 )
2019
32
Bacterial meningitis and cauda equina syndrome after trans-sacral epiduroscopic laser decompression: A case report. ( 30882691 )
2019
33
Prevalence of Bacteremia and Bacterial Meningitis in Febrile Neonates and Infants in the Second Month of Life: A Systematic Review and Meta-analysis. ( 30901044 )
2019
34
Intracranial Hemorrhage Caused by Bacterial Meningitis: Case Report and Review of the Literature. ( 30937042 )
2019
35
The Role of Microglia in Bacterial Meningitis: Inflammatory Response, Experimental Models and New Neuroprotective Therapeutic Strategies. ( 30967852 )
2019
36
Severe bacterial meningitis due to an enterothecal fistula in a 6-year-old child with Currarino syndrome: evaluation of surgical strategy with review of the literature. ( 30968178 )
2019
37
Acute Community-Acquired Bacterial Meningitis: Update on Clinical Presentation and Prognostic factors. ( 30994177 )
2019
38
Immediate Neutrophil-Variable-T Cell Receptor Host Response in Bacterial Meningitis. ( 31001192 )
2019
39
The clinical characteristics of spontaneous Gram-negative bacterial meningitis in adults: A hospital-based study. ( 31005474 )
2019
40
Performance of lactate in discriminating bacterial meningitis from enteroviral meningitis. ( 31017185 )
2019
41
Update and advances in community acquired bacterial meningitis. ( 31021955 )
2019
42
The FOUR score as predictor of outcome in adults with bacterial meningitis. ( 31053662 )
2019
43
"Time is brain" also for bacterial meningitis. ( 31090801 )
2019
44
Validation of multiplex PCR for the diagnosis of acute bacterial meningitis in culture negative cerebrospinal fluid. ( 31090802 )
2019
45
Cerebrospinal Fluid Lactate as an Indicator for Post-neurosurgical Bacterial Meningitis. ( 31097888 )
2019
46
Rapid detection of bacterial meningitis using a point-of-care glucometer. ( 28799985 )
2019
47
Neonatal bacterial meningitis: a systematic review of European available data. ( 29160642 )
2019
48
The combination of cerebrospinal fluid procalcitonin, lactate, interleukin-8 and interleukin-10 concentrations for the diagnosis of postneurosurgical bacterial meningitis: A prospective study. ( 30056757 )
2019
49
Lumbar Puncture Is Safe in Bacterial Meningitis: Impaired Mental Status Alone Does Not Motivate Cranial Computed Tomography Before Lumbar Puncture. ( 30084922 )
2019
50
Bacterial Meningitis Caused by β-lactamase Non-producing Ampicillin-resistant Haemophilus influenzae Type f in an Immunocompetent Woman. ( 30146561 )
2019

Variations for Meningitis

Expression for Meningitis

Search GEO for disease gene expression data for Meningitis.

Pathways for Meningitis

Pathways related to Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.09 CCL4 CFP CRP CXCL1 CXCL8 IFNG
2
Show member pathways
13.51 CCL4 CXCL1 CXCL8 IL10 IL1B IL6
3
Show member pathways
13.46 CCL4 CXCL1 CXCL8 IFNG IL10 IL1B
4
Show member pathways
13.35 CCL4 CXCL1 CXCL8 IL10 IL1B IL6
5
Show member pathways
13.07 CCL4 CXCL1 CXCL8 IL1B IL6 IRAK4
6
Show member pathways
13.04 CCL4 CXCL1 CXCL8 IFNG IL10 IL1B
7
Show member pathways
12.94 CXCL8 IFNG IL10 IL1B IL6 TNF
8
Show member pathways
12.86 CCL4 CXCL8 IFNG IL1B IL6 TNF
9
Show member pathways
12.75 IL1B IL6 IRAK4 TLR2 TNF
10
Show member pathways
12.71 IFNG IL10 IL1B IL6 TLR2 TNF
11
Show member pathways
12.7 CXCL1 IFNG IL10 IL1B IL6 TNF
12 12.67 IFNG IL10 IL1B IRAK4 TLR2 TNF
13
Show member pathways
12.65 IFNG IL10 IL1B IL6 TNF
14
Show member pathways
12.47 ALB CRP IFNG IL1B IL6 TNF
15
Show member pathways
12.44 CXCL8 IFNG IL1B IL6 IRAK4 TNF
16
Show member pathways
12.39 IFNG IL10 IL1B IRAK4 TLR2 TNF
17
Show member pathways
12.39 CXCL1 CXCL8 IFNG IL1B IL6 MMP9
18
Show member pathways
12.38 CXCL8 IL6 IRAK4 TLR2 TNF
19
Show member pathways
12.38 CXCL8 IFNG IL10 IL1B IL6 TNF
20
Show member pathways
12.36 CXCL8 IL1B IL6 IRAK4 TLR2 TNF
21 12.36 IFNG IL10 IL1B IL6 IRAK4 TLR2
22
Show member pathways
12.34 IL10 IL1B IL6 NLRP3 TNF
23
Show member pathways
12.34 CCL4 CXCL1 CXCL8 IL1B IRAK4 MMP9
24 12.31 IFNG IL6 MMP9 TLR2 TNF
25
Show member pathways
12.31 CXCL8 IFNG IL1B IL6 IRAK4 TLR2
26 12.29 CXCL8 IL10 IL1B IL6 TNF
27
Show member pathways
12.27 IFNG IL1B NLRP3 TNF
28
Show member pathways
12.2 IFNG IL10 IL1B IL6 TLR2 TNF
29
Show member pathways
12.19 CCL4 CXCL8 IFNG IL10 IL1B IL6
30
Show member pathways
12.18 IFNG IL1B IL6 MMP9 TLR2 TNF
31 12.17 IFNG IL1B MMP9 TNF
32 12.13 CXCL8 IL10 IL1B IL6 MMP9 TNF
33 12.11 CXCL1 IL1B IL6 MMP9 TNF
34 12.1 CXCL1 CXCL8 IFNG IL1B IL6 MMP9
35 12.09 CXCL1 CXCL8 IFNG IL1B IL6
36 12.08 IFNG IL10 IL6 TNF
37 12.04 CCL4 CXCL8 IL1B IRAK4 TNF
38 12.01 CXCL8 IL1B IL6 TNF
39 11.97 CCL4 CXCL1 CXCL8 IFNG IL1B IL6
40 11.94 CXCL1 CXCL8 IFNG IL1B IL6 TLR2
41 11.91 IFNG IL10 IL1B TNF
42 11.9 IFNG IL10 IL1B IL6 TNF
43 11.83 CXCL8 IFNG IL6
44 11.83 CXCL8 IL10 IL1B IL6 IRAK4 NLRP3
45
Show member pathways
11.8 CXCL8 IFNG TNF
46 11.8 CCL4 CXCL8 IL1B IL6 MMP9 TNF
47
Show member pathways
11.79 CXCL8 IFNG IL1B IL6 MMP9 TNF
48 11.73 CXCL8 IL6 MMP9
49 11.71 CXCL1 CXCL8 IL1B IL6 TLR2 TNF
50 11.66 IFNG IL1B TLR2 TNF

GO Terms for Meningitis

Cellular components related to Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 ALB CCL4 CFP CRP CXCL1 CXCL8
2 extracellular space GO:0005615 9.55 ADA ALB CCL4 CFP CRP CXCL1
3 tertiary granule lumen GO:1904724 9.46 CFP CXCL1 LYZ MMP9
4 specific granule lumen GO:0035580 9.43 CFP CXCL1 LYZ

Biological processes related to Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 defense response GO:0006952 9.97 CXCL1 CXCL8 NLRP3 TNF
2 regulation of signaling receptor activity GO:0010469 9.97 CCL4 CXCL1 CXCL8 IFNG IL10 IL1B
3 immune response GO:0006955 9.96 CCL4 CFP CXCL1 CXCL8 IFNG IL10
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.94 IL10 IL1B IL6 TNF
5 chemokine-mediated signaling pathway GO:0070098 9.89 CCL4 CXCL1 CXCL8
6 regulation of insulin secretion GO:0050796 9.89 IFNG IL1B TNF
7 neutrophil chemotaxis GO:0030593 9.89 CCL4 CXCL1 CXCL8 IL1B
8 humoral immune response GO:0006959 9.88 IFNG IL6 TNF
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.88 IL6 IRAK4 TNF
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 IL1B IL6 IRAK4 NLRP3 TLR2 TNF
11 cellular response to lipopolysaccharide GO:0071222 9.87 CXCL1 CXCL8 IL10 IL1B IL6 NLRP3
12 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.86 IL1B TLR2 TNF
13 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.86 IL10 MMP9 TNF
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.85 IFNG IL1B TNF
15 positive regulation of phagocytosis GO:0050766 9.84 IL1B MBL2 TNF
16 acute-phase response GO:0006953 9.83 CRP IL6 MBL2
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.83 IL1B TLR2 TNF
18 positive regulation of interleukin-8 production GO:0032757 9.81 IL1B TLR2 TNF
19 positive regulation of interleukin-6 production GO:0032755 9.81 IL1B IL6 TLR2 TNF
20 negative regulation of neurogenesis GO:0050768 9.79 IL1B IL6 TNF
21 leukocyte chemotaxis GO:0030595 9.79 CXCL1 CXCL8 IL10
22 positive regulation of chemokine production GO:0032722 9.76 IL6 TLR2 TNF
23 embryonic digestive tract development GO:0048566 9.75 ADA CXCL8 TNF
24 positive regulation of glial cell proliferation GO:0060252 9.74 IL1B IL6 TNF
25 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IFNG IL1B TNF
26 opsonization GO:0008228 9.72 CRP MBL2
27 response to glucocorticoid GO:0051384 9.72 IL10 IL6 TNF
28 endothelial cell apoptotic process GO:0072577 9.71 IL10 TNF
29 neutrophil mediated immunity GO:0002446 9.71 IL6 IRAK4
30 positive regulation of chemokine biosynthetic process GO:0045080 9.71 IL1B