MCID: MNN024
MIFTS: 29

Meningitis and Encephalitis

Categories: Neuronal diseases

Aliases & Classifications for Meningitis and Encephalitis

MalaCards integrated aliases for Meningitis and Encephalitis:

Name: Meningitis and Encephalitis 53

Classifications:



Summaries for Meningitis and Encephalitis

NINDS : 53 Meningitis is an infection of the meninges, the membranes that surround the brain and spinal cord. Encephalitis is inflammation of the brain itself. Anyone can get encephalitis or meningitis. Causes of encephalitis and meningitis include viruses, bacteria, fungus, and parasites. Anyone experiencing symptoms of meningitis or encephalitis should see a doctor immediately. Symptoms of encephalitis that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia. Other symptoms include: sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, irritability. In more severe cases, people may have problems with speech or hearing, vision problems, and hallucinations. Symptoms of meningitis, which may appear suddenly, often include: high fever, severe and persistent headache, stiff neck, nausea, sensitivity to bright light, vomiting, and changes in behavior such as confusion, sleepiness, and difficulty waking up. In infants, symptoms of meningitis or encephalitis may include fever, vomiting, lethargy, body stiffness, unexplained irritability, and a full or bulging fontanel (the soft spot on the top of the head).

MalaCards based summary : Meningitis and Encephalitis is related to meningitis and aseptic meningitis. An important gene associated with Meningitis and Encephalitis is ALB (Albumin), and among its related pathways/superpathways are Longevity regulating pathway and Amyotrophic lateral sclerosis (ALS). The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone, and related phenotype is neoplasm.

Related Diseases for Meningitis and Encephalitis

Diseases related to Meningitis and Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 meningitis 31.4 CAT ALB
2 aseptic meningitis 30.5 SOD1 CAT
3 gastroenteritis 28.7 CP CAT ALB
4 meningoencephalitis 11.6
5 encephalitis 10.9
6 bacterial meningitis 10.6
7 haemophilus influenzae 10.5
8 viral meningitis 10.4
9 tick-borne encephalitis 10.4
10 herpes simplex 10.4
11 mumps 10.3
12 viral encephalitis 10.3
13 chickenpox 10.3
14 tuberculous meningitis 10.3
15 japanese encephalitis 10.3
16 measles 10.2
17 west nile virus 10.2
18 meningococcal meningitis 10.2
19 herpes simplex encephalitis 10.2
20 lymphocytic choriomeningitis 10.1
21 poliomyelitis 10.1
22 bacterial infectious disease 10.0
23 meningococcal infection 10.0
24 infectious encephalitis 10.0
25 spinal cord disease 10.0 SOD1 ALB
26 extrinsic allergic alveolitis 10.0 SOD1 ALB
27 carbuncle 10.0 CAT ALB
28 prolapse of urethra 10.0 CAT ALB
29 brain edema 10.0 SOD1 ALB
30 erysipelas 10.0 SOD1 CAT
31 multidrug-resistant tuberculosis 10.0 CAT ALB
32 myocardial stunning 10.0 SOD1 CAT
33 actinomycosis 10.0 CAT ALB
34 ocular motor apraxia 10.0
35 exanthem 10.0
36 parotitis 10.0
37 rabies 10.0
38 rubella 10.0
39 intracranial hypertension 10.0
40 neisseria meningitidis infection 10.0
41 encephalopathy 10.0
42 pneumococcal meningitis 10.0
43 renovascular hypertension 10.0 SOD1 CAT
44 endocardium disease 10.0 CAT ALB
45 hyperphenylalaninemia 9.9 SOD1 CAT
46 social phobia 9.9 SOD1 CAT
47 retinal ischemia 9.9 SOD1 CAT
48 acute kidney failure 9.9 CAT ALB
49 peptic ulcer disease 9.9 CAT ALB
50 microvascular complications of diabetes 5 9.9 SOD1 ALB

Graphical network of the top 20 diseases related to Meningitis and Encephalitis:



Diseases related to Meningitis and Encephalitis

Symptoms & Phenotypes for Meningitis and Encephalitis

MGI Mouse Phenotypes related to Meningitis and Encephalitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.8 ALB CAT SOD1

Drugs & Therapeutics for Meningitis and Encephalitis

Drugs for Meningitis and Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 1
2 Immunologic Factors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3´Δ30 Chimeric Virus Vaccine (WN/DEN4Δ30), a Live Attenuated Vaccine for West Nile Encephalitis, in Flavivirus-naïve Adults 50-65 Years of Age Completed NCT02186626 Phase 1
2 Microbiome Translocation in Different Circulatory Compartments in Decompensated Cirrhosis Recruiting NCT04195724
3 Clinical Evaluation of the FilmArray® Meningitis/Encephalitis (ME) Panel Not yet recruiting NCT03895281
4 NIHR Global Health Research Group on Brain Infections Study: Establishing a Standard Care Package to Improve Diagnosis and Early Hospital Management of Patients With Suspected Acute Brain Infections in Low and Middle Income Countries Not yet recruiting NCT04190303

Search NIH Clinical Center for Meningitis and Encephalitis

Genetic Tests for Meningitis and Encephalitis

Anatomical Context for Meningitis and Encephalitis

MalaCards organs/tissues related to Meningitis and Encephalitis:

40
Brain, Spinal Cord, Bone, Kidney, Testes, Bone Marrow, Myeloid

Publications for Meningitis and Encephalitis

Articles related to Meningitis and Encephalitis:

(show top 50) (show all 436)
# Title Authors PMID Year
1
An update on Toscana virus distribution, genetics, medical and diagnostic aspects. 61
31904562 2020
2
Acute Kidney Injury with Neurological Features: Beware of the Star Fruit and its Caramboxin. 61
32015601 2020
3
Critical care management of infectious meningitis and encephalitis. 61
31938828 2020
4
Antifungal triazole posaconazole targets an early stage of the parechovirus A3 life cycle. 61
31818821 2019
5
Diagnostic challenges of central nervous system infection: extensive multiplex panels versus stepwise guided approach. 61
31899336 2019
6
Analysis of emergency department prediction tools in evaluating febrile young infants at risk for serious infections. 61
31653694 2019
7
Optic nerve sheath diameter: present and future perspectives for neurologists and critical care physicians. 61
31367861 2019
8
A prospective study on the clinical profile and outcome of meningoencephalitis in adults in a South Indian tertiary care centre. 61
31808453 2019
9
Usutu virus disease: a potential problem for North America? 61
31858483 2019
10
West Nile Virus Induced Cell Death in the Central Nervous System. 61
31683807 2019
11
Hypoxia and therapeutic treatment of EV-A71 with an immune modulator TLR7 agonist in a new immunocompetent mouse model. 61
31711481 2019
12
Impact of a multiplex PCR assay (FilmArray®) on the management of patients with suspected central nervous system infections. 61
31720944 2019
13
Meningitis and encephalitis management in the ICU. 61
31306182 2019
14
Usefulness of the FilmArray meningitis/encephalitis (M/E) panel for the diagnosis of infectious meningitis and encephalitis in Taiwan. 61
31085115 2019
15
Donor-derived infections: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. 61
30903670 2019
16
Evaluation of the BioFire FilmArray meningitis/encephalitis panel for the detection of bacteria and yeast in Chinese children. 61
31700873 2019
17
Varicella zoster virus infection of the central nervous system in a tertiary care center in Lebanon. 61
31526545 2019
18
Molecular Mechanism of the Flexible Glycan Receptor Recognition by Mumps Virus. 61
31118251 2019
19
New and novel rapid diagnostics that are impacting infection prevention and antimicrobial stewardship. 61
31135388 2019
20
Invasive Cryptococcal Meningitis Presenting as a Skull Base Mass in An Immunocompetent Host: A Case Report. 61
31328082 2019
21
The role of CNS macrophages in streptococcal meningoencephalitis. 61
30762892 2019
22
JC Virus Infection: A Clinical Conundrum. 61
31142409 2019
23
Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis. 61
31189036 2019
24
Diagnostic accuracy of a commercial multiplex PCR for the diagnosis of meningitis and encephalitis in an Italian general hospital. 61
31205036 2019
25
The etiology of acute meningitis and encephalitis syndromes in a sentinel pediatric hospital, Shenzhen, China. 61
31242869 2019
26
Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. 61
30879893 2019
27
Meningitis with cranial polyneuritis and cavernous sinus thrombosis by Borrelia crocidurae: First autochthonous case in Europe. 61
30818047 2019
28
Laboratory validation of a clinical metagenomic sequencing assay for pathogen detection in cerebrospinal fluid. 61
30992304 2019
29
[Trends on the epidemics of acute meningitis and encephalitis among population under 18 years-old in Shijiazhuang city, 2007-2017]. 61
31006201 2019
30
Cost of managing meningitis and encephalitis among infants and children in the United States. 61
30442508 2019
31
Development and validation of an advanced fragment analysis-based assay for the detection of 22 pathogens in the cerebrospinal fluid of patients with meningitis and encephalitis. 61
30666716 2019
32
A Challenge between Central Nervous System Infection and Lead Toxicity: Opioid Case Reports from Iran. 61
30936604 2019
33
Protean Neurologic Manifestations of Two Rare Dermatologic Disorders: Sweet Disease and Localized Craniofacial Scleroderma. 61
30747288 2019
34
The neonatal Fc receptor is a pan-echovirus receptor. 61
30808762 2019
35
[Acute meningitis and encephalitis syndrome surveillance disease burden in four China prefectures]. 61
30744290 2019
36
[Etiologic surveillance and analysis of acute meningitis and encephalitis syndrome in Jinan city in 2013-2016]. 61
30744292 2019
37
Interactions Between Enteroviruses and the Inflammasome: New Insights Into Viral Pathogenesis. 61
30858838 2019
38
Understanding parental perspectives on outcomes following paediatric encephalitis: A qualitative study. 61
31525232 2019
39
A review of a 13-month period of FilmArray Meningitis/Encephalitis panel implementation as a first-line diagnosis tool at a university hospital. 61
31647847 2019
40
Epidemiology of Meningitis and Encephalitis in Infants and Children in the United States, 2011-2014. 61
30531527 2019
41
FilmArray® meningitis/encephalitis (ME) panel, a rapid molecular platform for diagnosis of CNS infections in a tertiary care hospital in North India: one-and-half-year review. 61
30255486 2019
42
Rapidly progressive encephalopathy caused by Coxsackie meningoencephalitis in an elderly male. 61
30291563 2018
43
Community-acquired acute meningitis and encephalitis: a narrative review. 61
30309300 2018
44
Viral Meningitis and Encephalitis. 61
30273240 2018
45
Infectious meningitis and encephalitis in adults in Denmark: a prospective nationwide observational cohort study (DASGIB). 61
29409994 2018
46
An unusual case of inflammatory meningitis in a young man with systemic lupus erythematosus. 61
30092733 2018
47
Myocardial infarction in a patient with multiple sclerosis after receiving natalizumab. 61
30025371 2018
48
Listeria monocytogenes Infection of the Brain. 61
30346400 2018
49
Analytical validation of viral CNS Flow Chip kit for detection of acute meningitis and encephalitis. 61
29902492 2018
50
Evaluation of the Luminex ARIES HSV 1&2 Assay and Comparison with the FTD Neuro 9 and In-house Real-Time PCR Assays for Detecting Herpes Simplex Viruses. 61
29797814 2018

Variations for Meningitis and Encephalitis

Expression for Meningitis and Encephalitis

Search GEO for disease gene expression data for Meningitis and Encephalitis.

Pathways for Meningitis and Encephalitis

Pathways related to Meningitis and Encephalitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.61 SOD1 CAT
2
Show member pathways
11.46 SOD1 CAT
3 11.29 SOD1 CAT
4
Show member pathways
11.13 SOD1 CAT ALB
5
Show member pathways
11.09 SOD1 CP
6
Show member pathways
11 SOD1 CAT
7
Show member pathways
10.76 SOD1 CAT
8 10.45 SOD1 CAT

GO Terms for Meningitis and Encephalitis

Cellular components related to Meningitis and Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 SOD1 CP CAT ALB
2 blood microparticle GO:0072562 9.37 CP ALB
3 peroxisome GO:0005777 9.32 SOD1 CAT
4 extracellular exosome GO:0070062 9.26 SOD1 CP CAT ALB
5 mitochondrial intermembrane space GO:0005758 9.16 SOD1 CAT
6 extracellular space GO:0005615 8.92 SOD1 CP CAT ALB

Biological processes related to Meningitis and Encephalitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.61 SOD1 CP CAT
2 negative regulation of apoptotic process GO:0043066 9.5 SOD1 CAT ALB
3 response to oxidative stress GO:0006979 9.49 SOD1 CAT
4 platelet degranulation GO:0002576 9.48 SOD1 ALB
5 response to ethanol GO:0045471 9.46 SOD1 CAT
6 cellular response to oxidative stress GO:0034599 9.4 SOD1 CAT
7 cellular oxidant detoxification GO:0098869 9.37 CAT ALB
8 cellular iron ion homeostasis GO:0006879 9.26 SOD1 CP
9 response to hydrogen peroxide GO:0042542 9.16 SOD1 CAT
10 retina homeostasis GO:0001895 8.96 SOD1 ALB
11 response to reactive oxygen species GO:0000302 8.62 SOD1 CAT

Molecular functions related to Meningitis and Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.43 SOD1 CP CAT
2 chaperone binding GO:0051087 9.33 SOD1 CP ALB
3 copper ion binding GO:0005507 9.13 SOD1 CP ALB
4 antioxidant activity GO:0016209 8.8 SOD1 CAT ALB

Sources for Meningitis and Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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