MCID: MNN024
MIFTS: 31

Meningitis and Encephalitis

Categories: Neuronal diseases

Aliases & Classifications for Meningitis and Encephalitis

MalaCards integrated aliases for Meningitis and Encephalitis:

Name: Meningitis and Encephalitis 54

Classifications:



Summaries for Meningitis and Encephalitis

NINDS : 54 Meningitis is an infection of the meninges, the membranes that surround the brain and spinal cord. Encephalitis is inflammation of the brain itself. Anyone can get encephalitis or meningitis. Causes of encephalitis and meningitis include viruses, bacteria, fungus, and parasites. Anyone experiencing symptoms of meningitis or encephalitis should see a doctor immediately. Symptoms of encephalitis that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia. Other symptoms include: sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, irritability. In more severe cases, people may have problems with speech or hearing, vision problems, and hallucinations. Symptoms of meningitis, which may appear suddenly, often include: high fever, severe and persistent headache, stiff neck, nausea, sensitivity to bright light, vomiting, and changes in behavior such as confusion, sleepiness, and difficulty waking up. In infants, symptoms of meningitis or encephalitis may include fever, vomiting, lethargy, body stiffness, unexplained irritability, and a full or bulging fontanel (the soft spot on the top of the head).

MalaCards based summary : Meningitis and Encephalitis is related to meningoencephalitis and meningitis. An important gene associated with Meningitis and Encephalitis is CP (Ceruloplasmin), and among its related pathways/superpathways are Longevity regulating pathway and Amyotrophic lateral sclerosis (ALS). Affiliated tissues include brain, spinal cord and testes, and related phenotypes are cellular and neoplasm

Related Diseases for Meningitis and Encephalitis

Graphical network of the top 20 diseases related to Meningitis and Encephalitis:



Diseases related to Meningitis and Encephalitis

Symptoms & Phenotypes for Meningitis and Encephalitis

MGI Mouse Phenotypes related to Meningitis and Encephalitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.26 ALB CAT CP SOD1
2 neoplasm MP:0002006 8.8 ALB CAT SOD1

Drugs & Therapeutics for Meningitis and Encephalitis

Search Clinical Trials , NIH Clinical Center for Meningitis and Encephalitis

Genetic Tests for Meningitis and Encephalitis

Anatomical Context for Meningitis and Encephalitis

MalaCards organs/tissues related to Meningitis and Encephalitis:

41
Brain, Spinal Cord, Testes, B Cells, Kidney, Liver

Publications for Meningitis and Encephalitis

Articles related to Meningitis and Encephalitis:

(show all 39)
# Title Authors Year
1
Epidemiology of Meningitis and Encephalitis in Infants and Children in the United States, 2011-2014. ( 30531527 )
2019
2
Evaluation of a Commercial Multiplex Molecular Panel For the Diagnosis of Infectious Meningitis and Encephalitis. ( 29436421 )
2018
3
Cost of managing meningitis and encephalitis among infants and children in the United States. ( 30442508 )
2018
4
Viral Meningitis and Encephalitis. ( 30273240 )
2018
5
Community-acquired acute meningitis and encephalitis: a narrative review. ( 30309300 )
2018
6
Cost of managing meningitis and encephalitis among adult patients in the United States of America. ( 29702265 )
2018
7
Analytical validation of viral CNS Flow Chip kit for detection of acute meningitis and encephalitis. ( 29902492 )
2018
8
Infectious meningitis and encephalitis in adults in Denmark: a prospective nationwide observational cohort study (DASGIB). ( 29409994 )
2018
9
Outcome of Patients with Meningitis and Encephalitis at Tertiary Care Hospital in Eastern Nepal. ( 29446361 )
2017
10
Emergency Neurologic Life Support: Meningitis and Encephalitis. ( 28916998 )
2017
11
Meningitis and encephalitis in Poland in 2015 ( 29415527 )
2017
12
Epidemiology of Meningitis and Encephalitis in the United States, 2011-2014. ( 28419350 )
2017
13
Autoimmune meningitis and encephalitis in adult-onset still disease - Case report. ( 28720215 )
2017
14
Infectious Meningitis and Encephalitis. ( 27643906 )
2016
15
Mumps-associated meningitis and encephalitis in patients with no suspected mumps infection. ( 24674094 )
2014
16
Viral meningitis and encephalitis. ( 23981453 )
2013
17
Establishing surveillance for acute meningitis and encephalitis syndromes through expansion of poliomyelitis and measles surveillance networks in Bangladesh,China and India, 2006a892008. ( 23311008 )
2012
18
Completeness of West Nile virus testing in patients with meningitis and encephalitis during an outbreak in Arizona, USA. ( 22123531 )
2012
19
Expanding poliomyelitis and measles surveillance networks to establish surveillance for acute meningitis and encephalitis syndromes--Bangladesh, China, and India, 2006-2008. ( 23235298 )
2012
20
Relapsing polychondritis-associated meningitis and encephalitis: response to infliximab. ( 21622521 )
2011
21
Review of the etiologies of viral meningitis and encephalitis in a dengue endemic region. ( 21292281 )
2011
22
Aseptic meningitis and encephalitis because of herpesviruses and enteroviruses in an immunocompetent adult population. ( 18637823 )
2008
23
Etiology of aseptic meningitis and encephalitis in an adult population. ( 16401850 )
2006
24
Evaluation of antioxidant status in children with acute bacterial meningitis and encephalitis. ( 14585750 )
2003
25
Viral meningitis and encephalitis: traditional and emerging viral agents. ( 12881794 )
2003
26
Polymerase chain reaction for the laboratory diagnosis of aseptic meningitis and encephalitis. ( 11018820 )
2000
27
Multicenter evaluation of the Amplicor Enterovirus PCR test with cerebrospinal fluid from patients with aseptic meningitis. The European Union Concerted Action on Viral Meningitis and Encephalitis. ( 9705409 )
1998
28
Polymerase chain reaction for detection of JC virus DNA in cerebrospinal fluid: a quality control study. European Union Concerted Action on Viral Meningitis and Encephalitis. ( 9504768 )
1997
29
[Evaluation of tumor necrosis factor and C-reactive protein level determination in cerebrospinal fluid of meningitis and encephalitis]. ( 9424322 )
1997
30
Aseptic meningitis and encephalitis: the role of PCR in the diagnostic laboratory. ( 9041414 )
1997
31
The role of laboratory investigation in the diagnosis and management of patients with suspected herpes simplex encephalitis: a consensus report. The EU Concerted Action on Virus Meningitis and Encephalitis. ( 8890768 )
1996
32
Viral meningitis and encephalitis. ( 1455104 )
1992
33
Viral meningitis and encephalitis in Saudi Arabia. ( 2585577 )
1989
34
Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients. ( 3135367 )
1988
35
Mumps virus meningitis and encephalitis without parotitis. ( 750438 )
1978
36
Cerebritis, aseptic meningitis and encephalitis. Individual and community implications. ( 5410113 )
1970
37
A study of viral etiology of aseptic meningitis and encephalitis in Cairo. ( 4313988 )
1969
38
An etiologic study of seasonal aseptic meningitis and encephalitis in the Central Valley of California. ( 14464001 )
1961
39
Acute serous meningitis and encephalitis complicating scarlet fever. ( 18118945 )
1949

Variations for Meningitis and Encephalitis

Expression for Meningitis and Encephalitis

Search GEO for disease gene expression data for Meningitis and Encephalitis.

Pathways for Meningitis and Encephalitis

GO Terms for Meningitis and Encephalitis

Cellular components related to Meningitis and Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 ALB CAT CP SOD1
2 myelin sheath GO:0043209 9.4 ALB SOD1
3 blood microparticle GO:0072562 9.37 ALB CP
4 peroxisome GO:0005777 9.32 CAT SOD1
5 extracellular exosome GO:0070062 9.26 ALB CAT CP SOD1
6 mitochondrial intermembrane space GO:0005758 9.16 CAT SOD1
7 extracellular space GO:0005615 8.92 ALB CAT CP SOD1

Biological processes related to Meningitis and Encephalitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.61 CAT CP SOD1
2 cellular protein metabolic process GO:0044267 9.52 ALB CP
3 aging GO:0007568 9.51 CAT SOD1
4 negative regulation of apoptotic process GO:0043066 9.5 ALB CAT SOD1
5 response to oxidative stress GO:0006979 9.49 CAT SOD1
6 platelet degranulation GO:0002576 9.48 ALB SOD1
7 response to ethanol GO:0045471 9.46 CAT SOD1
8 cellular response to oxidative stress GO:0034599 9.4 CAT SOD1
9 cellular oxidant detoxification GO:0098869 9.37 ALB CAT
10 cellular iron ion homeostasis GO:0006879 9.26 CP SOD1
11 response to hydrogen peroxide GO:0042542 9.16 CAT SOD1
12 retina homeostasis GO:0001895 8.96 ALB SOD1
13 response to reactive oxygen species GO:0000302 8.62 CAT SOD1

Molecular functions related to Meningitis and Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.67 ALB CAT CP SOD1
2 identical protein binding GO:0042802 9.5 ALB CAT SOD1
3 oxidoreductase activity GO:0016491 9.43 CAT CP SOD1
4 chaperone binding GO:0051087 9.33 ALB CP SOD1
5 copper ion binding GO:0005507 9.13 ALB CP SOD1
6 antioxidant activity GO:0016209 8.8 ALB CAT SOD1

Sources for Meningitis and Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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