MCID: MNN007
MIFTS: 37

Meningocele

Categories: Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Meningocele

MalaCards integrated aliases for Meningocele:

Name: Meningocele 12 74 52 29 54 43 15 71
Congenital Meningocele 71
Spinal Meningocele 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1088
MeSH 43 D008588
SNOMED-CT 67 32941003
UMLS 71 C0009730 C0025299 C1261470

Summaries for Meningocele

MalaCards based summary : Meningocele, also known as congenital meningocele, is related to sacrococcygeal teratoma and neural tube defects. An important gene associated with Meningocele is NOTCH3 (Notch Receptor 3), and among its related pathways/superpathways is Gene regulatory network modelling somitogenesis. Affiliated tissues include spinal cord, brain and bone, and related phenotypes are cellular and embryo

Wikipedia : 74 Spina bifida is a birth defect in which there is incomplete closing of the spine and membranes around... more...

Related Diseases for Meningocele

Diseases in the Meningocele family:

Posterior Meningocele

Diseases related to Meningocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 289)
# Related Disease Score Top Affiliating Genes
1 sacrococcygeal teratoma 32.9 MNX1 AFP
2 neural tube defects 31.5 VANGL1 RPL34 NF1 MNX1 MESP2 ALX3
3 intracranial hypotension 30.4 RPL34 CRLF1
4 arachnoiditis 30.0 RPL34 CRLF1
5 tethered spinal cord syndrome 29.9 VANGL1 RPL34 MNX1 AFP
6 obstructive hydrocephalus 29.9 NF1 CRLF1 AFP
7 scoliosis 29.6 VANGL1 NF1 MESP2 HES7
8 hajdu-cheney syndrome 29.6 MESP2 HES7
9 spondylocostal dysostosis 1, autosomal recessive 29.5 MESP2 HES7
10 spondylocostal dysostosis, autosomal recessive 29.5 MESP2 HES7
11 adams-oliver syndrome 29.0 XXYLT1 NOTCH3 MESP2 HES7
12 lateral meningocele syndrome 12.9
13 sacral defect with anterior meningocele 12.7
14 cranial meningocele 12.3
15 posterior meningocele 12.3
16 sacral meningocele conotruncal heart defects 12.3
17 myelomeningocele 11.7
18 currarino syndrome 11.7
19 superficial siderosis 11.5
20 curry-jones syndrome 11.2
21 neurofibromatosis, type iv, of riccardi 10.8
22 hydrocephalus 10.5
23 meningitis 10.5
24 constipation 10.4
25 encephalocele 10.4
26 marfan syndrome 10.4
27 meningoencephalocele 10.4
28 urachal adenocarcinoma 10.4 NF1 AFP
29 epididymal neoplasm 10.4 NF1 AFP
30 neurilemmoma of the fifth cranial nerve 10.3 NF1 CRLF1
31 neurofibromatosis, type i 10.3
32 central nervous system hemangioma 10.3 RPL34 NF1
33 trigeminal nerve neoplasm 10.3 NF1 CRLF1
34 mollaret meningitis 10.3
35 corpus callosum lipoma 10.3 NF1 ALX3
36 back pain 10.3
37 chromosome 2p16.1-p15 deletion syndrome 10.3 USP34 SNORA70B
38 cerebral hemisphere lipoma 10.3 NF1 ALX3
39 hematocele of tunica vaginalis testis 10.3 CRLF1 AFP
40 cleft palate, isolated 10.3
41 dandy-walker syndrome 10.3
42 cystic teratoma 10.3
43 meningioma, radiation-induced 10.3
44 meningioma, familial 10.3
45 spinal meningioma 10.3
46 dermoid cyst 10.3
47 teratoma 10.3
48 secretory meningioma 10.3
49 lymphoplasmacyte-rich meningioma 10.3
50 ovarian cyst 10.3

Graphical network of the top 20 diseases related to Meningocele:



Diseases related to Meningocele

Symptoms & Phenotypes for Meningocele

MGI Mouse Phenotypes related to Meningocele:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 ALX3 C2CD3 MESP2 MNX1 NF1 NOTCH3
2 embryo MP:0005380 9.86 ALX3 C2CD3 HES7 MESP2 NF1 NOTCH3
3 mortality/aging MP:0010768 9.73 AFP ALX3 C2CD3 CRLF1 HES7 MESP2
4 limbs/digits/tail MP:0005371 9.7 ALX3 C2CD3 HES7 MESP2 NF1 TMEM67
5 skeleton MP:0005390 9.32 ALX3 HES7 MESP2 MNX1 NF1 NOTCH3

Drugs & Therapeutics for Meningocele

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long Term Assessment and Outcome of Adult Patients With Congenital Genitourinary Abnormalities. Recruiting NCT03061084
2 Study of Fetoscopic Repair of Myelomeningocele in Fetuses With Isolated Spina Bifida Recruiting NCT03090633

Search NIH Clinical Center for Meningocele

Cochrane evidence based reviews: meningocele

Genetic Tests for Meningocele

Genetic tests related to Meningocele:

# Genetic test Affiliating Genes
1 Meningocele 29

Anatomical Context for Meningocele

MalaCards organs/tissues related to Meningocele:

40
Spinal Cord, Brain, Bone, Skin, Eye, Heart, Colon

Publications for Meningocele

Articles related to Meningocele:

(show top 50) (show all 1526)
# Title Authors PMID Year
1
Prenatal diagnosis of sacrococcygeal teratoma with constitutional partial monosomy 7q/trisomy 2p. 54 61
14663834 2003
2
An antibody to Notch3 reverses the skeletal phenotype of lateral meningocele syndrome in male mice. 61
31188489 2020
3
Neurosurgical Management of Lateral Meningocele Syndrome: A Clinical Update for the Pediatric Neurosurgeon. 61
31838470 2019
4
Occipital teratoma in a neonate with CHARGE syndrome: a case report. 61
31797071 2019
5
Syringomyelia in children with closed spinal dysraphism: long-term outcomes after surgical intervention. 61
31835253 2019
6
One-Stage Anteroposterior Extensive Atlantoaxial Osteotomy Correction With 16 Months Follow-up: Technical Case Report. 61
31828342 2019
7
Meningocele Manqué Discovered During Filum Terminale Resection in Occult Tethered Cord Syndrome. 61
31430540 2019
8
Unilateral vagus nerve lesion revealing clival meningocele. 61
31221588 2019
9
Congenital meningocele associated with corpus callosum agenesis and midline superior labial cleft due to Tessier 0-14 facial fissure: A case report. 61
31706112 2019
10
Giant Symptomatic Meningocele as a Delayed, Adult Complication of Lipomyelomeningocele. 61
31760189 2019
11
Surgical outcomes of six bulldogs with spinal lumbosacral meningomyelocele or meningocele. 61
31758707 2019
12
[What's New in Papilloedema, Pseudotumor Cerebri and Idiopathic Intracranial Hypertension]. 61
31600818 2019
13
Neuropathic Pain due to Neurofibromatosis Treated With Transcutaneous Electrical Nerve Stimulation in a Pregnant Patient: A Case Report. 61
31361663 2019
14
Predictors of surgical treatment in children with tethered fibrofatty filum terminale. 61
31675690 2019
15
The reconstruction of skull base defects in infants using pedicled nasoseptal flap-a review of four cases. 61
30968177 2019
16
Anterior Sacral Meningocele: A New Classification and Treatment using the Dorsal Transsacral Approach. 61
31651686 2019
17
Surgical Repair of an Occipital Meningocele in a Foal. 61
31668304 2019
18
Anatomo-radiological study supporting the use of ipsilateral nasoseptal flap for the transpterygoid management of temporo-sphenoidal meningoceles. A review of 21 cases. 61
31631054 2019
19
Treatment of a sacral fracture associated with an intrasacral meningocele: A case report. 61
31315523 2019
20
A New Technique Using Modified Dehaan's Method for Median Cleft Lip Closure: A Case Report. 61
31448395 2019
21
Thoracic Meningocele and Cervical Syringomyelia Treated with Ventriculoperitoneal Shunt. 61
31152885 2019
22
Successful Management of a Giant Anterior Sacral Meningocele Associated with Low-Dysplastic Spondylolisthesis from a Single Posterior Approach: Case Report. 61
31009790 2019
23
Dural ectasia in Marfan syndrome and other hereditary connective tissue disorders: a 10-year follow-up study. 61
30998996 2019
24
Prevalence of Spontaneous Asymptomatic Facial Nerve Canal Meningoceles: A Retrospective Review. 61
31296524 2019
25
Retained medullary cord with sacral subcutaneous meningocele and congenital dermal sinus. 61
31297584 2019
26
Terminal syringomyelia associated with lumbar limited dorsal myeloschisis. 61
31317225 2019
27
Severe bacterial meningitis due to an enterothecal fistula in a 6-year-old child with Currarino syndrome: evaluation of surgical strategy with review of the literature. 61
30968178 2019
28
"Cable Suturing Technique" a Dural Obliteration Method for the Prevention of Cerebellar Herniation through a Large Occipital Meningocele. 61
31497162 2019
29
Prevalence of temporal bone tegmen defects among patients with Marfan syndrome. 61
30861355 2019
30
Optic Nerve Sheath Meningocele With Optic Disc Pit: A Rare Finding. 61
30664128 2019
31
Dural Ectasia of the Optic Nerve: A Rare Presentation in Neurofibromatosis Type I. 61
31001034 2019
32
Chiari malformations in adults: A single center surgical experience with special emphasis on the kinetics of clinical improvement. 61
30744958 2019
33
Neural Tube Defects: A Retrospective Study of 69 Cases. 61
31143270 2019
34
Short-term results of patients with neural tube defects followed-up in the Konya region, Turkey. 61
30708397 2019
35
Reconstructions With Different and New Techniques of Large and Extensive Myelomeningocele Defects. 61
30394972 2019
36
Assessment of Dural Ectasia Using Computed Tomodensitometry as a Criterion in Marfan Syndrome. 61
30371622 2019
37
Repair of a Transclival Meningocele Through a Transoral Approach: Case Report and Literature Review. 61
30579031 2019
38
Fallopian Canal Meningocele with Spontaneous Cerebrospinal Fluid Otorrhea: Case Report and Systematic Review of the Literature. 61
30321684 2019
39
An Unusual Presentation as Recurrent Abortions in a Case of Giant Presacral Epidermoid Cyst Mimicking an Anterior Sacral Meningocele. 61
31108068 2019
40
Spondylocostal Dysostosis Associated with Split Spinal Cord and Other Malformations. 61
31597143 2019
41
A Case Report of a 4-Year-Old Boy with Intradural Spinal Cord Abscess Successfully Treated with Adjuvant Hyperbaric Oxygen Therapy. 61
29757450 2019
42
Atypical presentation of currarino syndrome: A case report. 61
30933899 2019
43
Untreated meningomyelocele and squamous cell carcinoma: a case report and literature review. 61
30652927 2019
44
Rectothecal fistula complicating anterior sacral meningocele repair. 61
30386449 2019
45
Slender Stalk with Combined Features of Saccular Limited Dorsal Myeloschisis and Congenital Dermal Sinus in a Neonate. 61
30654374 2019
46
Late onset meningocele in a case of meningocele manqué. 61
30218141 2018
47
Optic nerve sheath meningocele associated with coloboma. 61
30270035 2018
48
Currarino syndrome: repair of the dysraphic anomalies and resection of the presacral mass in a combined neurosurgical and general surgical approach. 61
30095346 2018
49
Rupture of Giant Anterior Sacral Meningocele in a Patient with Marfan Syndrome: Diagnosis and Management. 61
30092475 2018
50
Caudal cell mass developmental aberrations: an imaging approach. 61
30138861 2018

Variations for Meningocele

Expression for Meningocele

Search GEO for disease gene expression data for Meningocele.

Pathways for Meningocele

Pathways related to Meningocele according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.66 MESP2 HES7

GO Terms for Meningocele

Biological processes related to Meningocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 artery morphogenesis GO:0048844 8.96 NOTCH3 NF1
2 Notch signaling pathway GO:0007219 8.8 NOTCH3 MESP2 HES7

Sources for Meningocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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