MCID: MNN007
MIFTS: 37

Meningocele

Categories: Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Meningocele

MalaCards integrated aliases for Meningocele:

Name: Meningocele 12 75 53 29 55 44 15 72
Congenital Meningocele 72
Spinal Meningocele 72

Classifications:



External Ids:

Disease Ontology 12 DOID:1088
MeSH 44 D008588
SNOMED-CT 68 32941003
UMLS 72 C0009730 C0025299 C1261470

Summaries for Meningocele

MalaCards based summary : Meningocele, also known as congenital meningocele, is related to lipomatosis, multiple and lateral meningocele syndrome. An important gene associated with Meningocele is NOTCH3 (Notch Receptor 3). Affiliated tissues include spinal cord, brain and bone, and related phenotypes are Resistant to vaccinia virus (VACV-A4L) infection and cellular

Wikipedia : 75 Spina bifida is a birth defect in which there is incomplete closing of the spine and membranes around... more...

Related Diseases for Meningocele

Diseases in the Meningocele family:

Posterior Meningocele

Diseases related to Meningocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 271)
# Related Disease Score Top Affiliating Genes
1 lipomatosis, multiple 29.6 MNX1 ALX3
2 lateral meningocele syndrome 12.9
3 sacral defect with anterior meningocele 12.7
4 cranial meningocele 12.3
5 posterior meningocele 12.3
6 sacral meningocele conotruncal heart defects 12.3
7 neural tube defects 11.8
8 myelomeningocele 11.7
9 currarino syndrome 11.7
10 superficial siderosis 11.5
11 sacrococcygeal teratoma 11.5
12 caudal regression sequence 11.2
13 curry-jones syndrome 11.2
14 neurofibromatosis, type iv, of riccardi 10.8
15 meningitis 10.5
16 hydrocephalus 10.5
17 congenital hydrocephalus 10.5
18 constipation 10.4
19 encephalocele 10.4
20 meningoencephalocele 10.4
21 marfan syndrome 10.4
22 neurofibromatosis, type i 10.3
23 tethered cord syndrome 10.3
24 scoliosis 10.3
25 mollaret meningitis 10.3
26 back pain 10.3
27 cleft palate, isolated 10.3
28 cystic teratoma 10.3
29 meningioma, radiation-induced 10.3
30 meningioma, familial 10.3
31 spinal meningioma 10.3
32 dermoid cyst 10.3
33 teratoma 10.3
34 secretory meningioma 10.3
35 lymphoplasmacyte-rich meningioma 10.3
36 ovarian cyst 10.3
37 mature teratoma 10.3
38 bacterial meningitis 10.3
39 arachnoid cysts 10.3
40 cerebrospinal fluid leak 10.3
41 neurofibroma 10.2
42 chiari malformation 10.2
43 syringomyelia, noncommunicating isolated 10.2
44 dandy-walker syndrome 10.2
45 pleomorphic lipoma 10.2
46 syringomyelia 10.2
47 paraplegia 10.2
48 intracranial hypertension 10.2
49 dandy-walker complex 10.2
50 epidermoid cysts 10.2

Graphical network of the top 20 diseases related to Meningocele:



Diseases related to Meningocele

Symptoms & Phenotypes for Meningocele

GenomeRNAi Phenotypes related to Meningocele according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Resistant to vaccinia virus (VACV-A4L) infection GR00351-A-1 8.92 IRF6 NOTCH3 USP34 VANGL1

MGI Mouse Phenotypes related to Meningocele:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.93 ALX3 IRF6 MNX1 NF1 NOTCH3 VANGL1
2 growth/size/body region MP:0005378 9.85 ALX3 IRF6 MNX1 NF1 NOTCH3 VANGL1
3 embryo MP:0005380 9.8 ALX3 IRF6 NF1 NOTCH3 VANGL1
4 digestive/alimentary MP:0005381 9.73 ALX3 IRF6 MNX1 NF1
5 mortality/aging MP:0010768 9.63 ALX3 IRF6 MNX1 NF1 NOTCH3 VANGL1
6 hearing/vestibular/ear MP:0005377 9.62 IRF6 NF1 NOTCH3 VANGL1
7 limbs/digits/tail MP:0005371 9.56 ALX3 IRF6 NF1 VANGL1
8 respiratory system MP:0005388 9.35 ALX3 MNX1 NF1 NOTCH3 VANGL1
9 skeleton MP:0005390 9.1 ALX3 IRF6 MNX1 NF1 NOTCH3 VANGL1

Drugs & Therapeutics for Meningocele

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long Term Assessment and Outcome of Adult Patients With Congenital Genitourinary Abnormalities. Recruiting NCT03061084
2 Study of Fetoscopic Repair of Myelomeningocele in Fetuses With Isolated Spina Bifida Recruiting NCT03090633

Search NIH Clinical Center for Meningocele

Cochrane evidence based reviews: meningocele

Genetic Tests for Meningocele

Genetic tests related to Meningocele:

# Genetic test Affiliating Genes
1 Meningocele 29

Anatomical Context for Meningocele

MalaCards organs/tissues related to Meningocele:

41
Spinal Cord, Brain, Bone, Skin, Eye, Heart, Colon

Publications for Meningocele

Articles related to Meningocele:

(show top 50) (show all 1511)
# Title Authors PMID Year
1
Prenatal diagnosis of sacrococcygeal teratoma with constitutional partial monosomy 7q/trisomy 2p. 9 38
14663834 2003
2
Successful Management of a Giant Anterior Sacral Meningocele Associated with Low-Dysplastic Spondylolisthesis from a Single Posterior Approach: Case Report. 38
31009790 2019
3
Thoracic Meningocele and Cervical Syringomyelia Treated with Ventriculoperitoneal Shunt. 38
31152885 2019
4
Treatment of a sacral fracture associated with an intrasacral meningocele: A case report. 38
31315523 2019
5
Meningocele Manqué Discovered During Filum Terminale Resection in Occult Tethered Cord Syndrome. 38
31430540 2019
6
Dural ectasia in Marfan syndrome and other hereditary connective tissue disorders: a 10-year follow-up study. 38
30998996 2019
7
Prevalence of Spontaneous Asymptomatic Facial Nerve Canal Meningoceles: A Retrospective Review. 38
31296524 2019
8
Neuropathic Pain due to Neurofibromatosis Treated With Transcutaneous Electrical Nerve Stimulation in a Pregnant Patient: A Case Report. 38
31361663 2019
9
Retained medullary cord with sacral subcutaneous meningocele and congenital dermal sinus. 38
31297584 2019
10
Terminal syringomyelia associated with lumbar limited dorsal myeloschisis. 38
31317225 2019
11
Severe bacterial meningitis due to an enterothecal fistula in a 6-year-old child with Currarino syndrome: evaluation of surgical strategy with review of the literature. 38
30968178 2019
12
An antibody to Notch3 reverses the skeletal phenotype of lateral meningocele syndrome in male mice. 38
31188489 2019
13
Unilateral vagus nerve lesion revealing clival meningocele. 38
31221588 2019
14
Prevalence of temporal bone tegmen defects among patients with Marfan syndrome. 38
30861355 2019
15
Dural Ectasia of the Optic Nerve: A Rare Presentation in Neurofibromatosis Type I. 38
31001034 2019
16
Chiari malformations in adults: A single center surgical experience with special emphasis on the kinetics of clinical improvement. 38
30744958 2019
17
Neural Tube Defects: A Retrospective Study of 69 Cases. 38
31143270 2019
18
The reconstruction of skull base defects in infants using pedicled nasoseptal flap-a review of four cases. 38
30968177 2019
19
Short-term results of patients with neural tube defects followed-up in the Konya region, Turkey. 38
30708397 2019
20
Reconstructions With Different and New Techniques of Large and Extensive Myelomeningocele Defects. 38
30394972 2019
21
Assessment of Dural Ectasia Using Computed Tomodensitometry as a Criterion in Marfan Syndrome. 38
30371622 2019
22
Repair of a Transclival Meningocele Through a Transoral Approach: Case Report and Literature Review. 38
30579031 2019
23
An Unusual Presentation as Recurrent Abortions in a Case of Giant Presacral Epidermoid Cyst Mimicking an Anterior Sacral Meningocele. 38
31108068 2019
24
Fallopian Canal Meningocele with Spontaneous Cerebrospinal Fluid Otorrhea: Case Report and Systematic Review of the Literature. 38
30321684 2019
25
Untreated meningomyelocele and squamous cell carcinoma: a case report and literature review. 38
30652927 2019
26
Rectothecal fistula complicating anterior sacral meningocele repair. 38
30386449 2019
27
Atypical presentation of currarino syndrome: A case report. 38
30933899 2019
28
Optic Nerve Sheath Meningocele With Optic Disc Pit: A Rare Finding. 38
30664128 2019
29
Slender Stalk with Combined Features of Saccular Limited Dorsal Myeloschisis and Congenital Dermal Sinus in a Neonate. 38
30654374 2019
30
Optic nerve sheath meningocele associated with coloboma. 38
30270035 2018
31
Late onset meningocele in a case of meningocele manqué. 38
30218141 2018
32
Rupture of Giant Anterior Sacral Meningocele in a Patient with Marfan Syndrome: Diagnosis and Management. 38
30092475 2018
33
Currarino syndrome: repair of the dysraphic anomalies and resection of the presacral mass in a combined neurosurgical and general surgical approach. 38
30095346 2018
34
Caudal cell mass developmental aberrations: an imaging approach. 38
30138861 2018
35
The lateral meningocele syndrome mutation causes marked osteopenia in mice. 38
30042232 2018
36
Prenatal diagnosis of closed spina bifida: multicenter case series and review of the literature. 38
30001658 2018
37
Ear and Temporal Bone Pathology: Neural, Sclerosing and Myofibroblastic Lesions. 38
30069839 2018
38
Enlargement of sacral subcutaneous meningocele associated with retained medullary cord. 38
29704125 2018
39
Leukocyte- and platelet-rich fibrin: a new graft material in endoscopic repair of spontaneous CSF leaks. 38
29982939 2018
40
Closure of a giant anterior sacral meningocele with an omental flap in a patient with Marfan syndrome: case report. 38
29799321 2018
41
Melanotic neuroectodermal tumour of infancy: A case report and differential diagnosis. 38
29125038 2018
42
Anterior sacral meningocele presenting as intracystic bleeding. 38
28523383 2018
43
Pharmacological resources, diagnostic approach and coordination of care in joint hypermobility-related disorders. 38
29979900 2018
44
Optic Nerve Sheath Meningocele Simulating an Optic Nerve Pit. 38
28746249 2018
45
Temporal Bone Meningocele Associated With Superior Canal Dehiscence. 38
29889793 2018
46
Rare Case of Tricompartmental Arachnoid Cyst Spanning Infratentorial, Supratentorial, and Extracranial Compartment and Presenting as Posterior Parietal Meningocele. 38
29698795 2018
47
[Dandy-Walker malformation]. 38
29797040 2018
48
Rare Case of Cerebrospinal Fluid Proctorrhea Caused by Anterior Sacral Meningocele with Rectothecal Fistula. 38
29572171 2018
49
Multiple neurosurgical treatments for different members of the same family with Currarino syndrome. 38
29731315 2018
50
Surgical Outcomes of Pediatric Patients with Asymptomatic Tethered Cord Syndrome. 38
29879784 2018

Variations for Meningocele

Expression for Meningocele

Search GEO for disease gene expression data for Meningocele.

Pathways for Meningocele

GO Terms for Meningocele

Biological processes related to Meningocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.46 NOTCH3 MNX1 IRF6 ALX3
2 pigmentation GO:0043473 8.96 VANGL1 NF1
3 artery morphogenesis GO:0048844 8.62 NOTCH3 NF1

Molecular functions related to Meningocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 8.8 MNX1 IRF6 ALX3

Sources for Meningocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....