Meningocele disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MNN007 MIFTS: 50	Meningocele Categories: Fetal diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Meningocele

MalaCards integrated aliases for Meningocele:

Name: Meningocele ¹¹ ¹⁹ ⁷⁵ ²⁸ ⁵³ ⁴³ ¹⁴ ⁷¹ ⁷⁵

Isolated Spina Bifida ¹⁹ ⁵⁸ ²⁸

Congenital Meningocele ⁷¹

Spinal Meningocele ⁷¹

Spinal Dysraphism ¹⁹

Spina Bifida ¹⁹

Rachischisis ¹⁹

Cleft Spine ¹⁹

Open Spine ¹⁹

Characteristics:

Inheritance:

Isolated Spina Bifida: Multigenic/multifactorial ⁵⁸

Prevelance:

Isolated Spina Bifida: 1-5/10000 (Europe, Europe, France, United States, Belgium, Croatia, Denmark, France, Germany, Hungary, Ireland, Italy, Malta, Netherlands, Norway, Poland, Portugal, Switzerland, United Kingdom, Ukraine) 1-9/100000 (Austria, Spain) ⁵⁸

Age Of Onset:

Isolated Spina Bifida: Infancy,Neonatal ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Congenital malformations, deformations and chromosomal abnormalities

Congenital malformations of the nervous system

Spina bifida

Cervical spina bifida with hydrocephalus

Cervical spina bifida without hydrocephalus

Lumbar spina bifida with hydrocephalus

Lumbar spina bifida without hydrocephalus

Sacral spina bifida with hydrocephalus

Sacral spina bifida without hydrocephalus

Spina bifida, unspecified

Thoracic spina bifida with hydrocephalus

Thoracic spina bifida without hydrocephalus

Unspecified spina bifida with hydrocephalus

Orphanet: ⁵⁸

Rare neurological diseases

Developmental anomalies during embryogenesis

External Ids:

Disease Ontology ¹¹ DOID:1088

MeSH ⁴³ D008588

SNOMED-CT ⁶⁸ 268308005

MESH via Orphanet ⁴⁴ D016135

ICD10 via Orphanet ³² Q05.0 Q05.1 Q05.2 more

UMLS via Orphanet ⁷² C0080178

Orphanet ⁵⁸ ORPHA823

UMLS ⁷¹ C0009730 C0025299 C1261470

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Summaries for Meningocele

Orphanet: ⁵⁸ A group of rare neural tube defect disorders characterized by improper closure of the spinal column during embryonal development, not associated with other major congenital malformations nor ventriculomegaly. The extent of the closure defect may vary, ranging from spina bifida occulta, in which the site of the lesion is not exposed (e.g. an isolated posterior vertebral arch defect), to spina bifida aperta, in which the lesion may be conformed of proturding spinal cord and meninges (myelomeningocele) or meninges exposure only (meningocele), with or without a proturding sac at the site of the lesion, to the most severe defect which includes total exposure of the spinal cord along its full length (rachischisis). Depending on the type, size and site of the defect, severe morbidity, typically inlcuding motor, sensory and sphincter dysfunction, and mortality may be associated. Spina bifida occulta may be asymptomatic.

MalaCards based summary: Meningocele, also known as isolated spina bifida, is related to lateral meningocele syndrome and cervical spina bifida aperta. An important gene associated with Meningocele is NOTCH3 (Notch Receptor 3), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Gene regulatory network modelling somitogenesis. The drugs Acetylcholine and Oxybutynin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and bone, and related phenotypes are nervous system and limbs/digits/tail

Disease Ontology: ¹¹ A spina bifida that is characterized by herniation of the meninges between the vertebrae.

GARD: ¹⁹ Protrusion of the meninges through a defect of the vertebral column.

Wikipedia: ⁷⁵ Spina bifida (Latin for 'split spine'; SB) is a birth defect in which there is incomplete closing of the... more...

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Related Diseases for Meningocele

Diseases in the Meningocele family:

Posterior Meningocele

Diseases related to Meningocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 786)

#	Related Disease	Score	Top Affiliating Genes
1	lateral meningocele syndrome	33.0	NOTCH3 MESP2 HES7
2	cervical spina bifida aperta	32.4	VANGL1 MTHFR
3	spina bifida occulta	32.4	VANGL1 MTHFR HES7 CELSR1 C2CD3
4	lumbosacral spina bifida cystica	32.2	VANGL1 MTHFR
5	cervical spina bifida cystica	32.2	VANGL1 MTHFR
6	total spina bifida aperta	32.2	VANGL1 MTHFR
7	cervicothoracic spina bifida aperta	32.2	VANGL1 MTHFR
8	lumbosacral spina bifida aperta	32.2	VANGL1 MTHFR
9	thoracolumbosacral spina bifida aperta	32.2	VANGL1 MTHFR
10	upper thoracic spina bifida aperta	32.2	VANGL1 MTHFR
11	total spina bifida cystica	32.2	VANGL1 MTHFR
12	thoracolumbosacral spina bifida cystica	32.2	VANGL1 MTHFR
13	cervicothoracic spina bifida cystica	32.1	VANGL1 MTHFR
14	upper thoracic spina bifida cystica	32.1	VANGL1 MTHFR
15	cloacal exstrophy	31.9	SHH MNX1
16	currarino syndrome	31.7	VANGL1 SHH MNX1
17	sacral defect with anterior meningocele	31.4	VANGL1 TCTE1 SHH MNX1 MESP2 HES7
18	myelomeningocele	31.2	VANGL1 MTHFR GRHL3 CELSR1
19	tethered spinal cord syndrome	30.8	VANGL1 MNX1 CELSR1 AFP
20	intracranial hypotension	30.4	PTGDS MTHFR
21	neural tube defects	30.3	VANGL1 SHH NF1 MTHFR MNX1 MESP2
22	teratoma	30.2	SHH MNX1 AFP
23	pulsating exophthalmos	30.2	PTGDS NF1
24	hajdu-cheney syndrome	30.0	NOTCH3 MESP2 HES7
25	spondylocostal dysostosis, autosomal recessive	29.9	MESP2 HES7
26	spondylocostal dysostosis 1, autosomal recessive	29.9	MESP2 HES7
27	cystic teratoma	29.9	MNX1 AFP
28	obstructive hydrocephalus	29.8	SHH NF1 AFP
29	dysostosis	29.8	SHH MESP2 HES7
30	spondylocostal dysostosis	29.8	NOTCH3 MESP2 HES7
31	adams-oliver syndrome	29.8	NOTCH3 MESP2 HES7
32	spondylocostal dysostosis 5	29.7	MESP2 HES7
33	omphalocele	29.6	SHH MNX1 AFP
34	cleft lip	28.9	SHH MTHFR GRHL3
35	anencephaly	28.9	VANGL1 SHH MTHFR GRHL3 CELSR1 AFP
36	orofacial cleft	28.9	SHH MTHFR GRHL3 C2CD3
37	split-hand with obstructive uropathy, spina bifida, and diaphragmatic defects	11.8
38	spina bifida aperta	11.8
39	spina bifida hypospadias	11.8
40	anencephaly and spina bifida x-linked	11.4
41	kasznica carlson coppedge syndrome	11.4
42	schisis association	11.3
43	acrofacial dysostosis, catania type	11.3
44	blepharocheilodontic syndrome 1	11.3
45	hypertrichosis, congenital anterior cervical, with peripheral sensory and motor neuropathy	11.3
46	male pseudohermaphroditism/mental retardation syndrome, verloes type	11.3
47	camptodactyly syndrome, guadalajara, type iii	11.3
48	acrodysplasia scoliosis	11.3
49	thakker-donnai syndrome	11.3
50	medeira-dennis-donnai syndrome	11.3

Graphical network of the top 20 diseases related to Meningocele:

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Symptoms & Phenotypes for Meningocele

MGI Mouse Phenotypes related to Meningocele:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	10.18	C2CD3 CELSR1 GRHL3 MESP2 MNX1 MTHFR
2	limbs/digits/tail	MP:0005371	10.07	C2CD3 CELSR1 GRHL3 HES7 MESP2 MTHFR
3	embryo	MP:0005380	10.02	C2CD3 CELSR1 GRHL3 HES7 MESP2 NF1
4	cellular	MP:0005384	10	C2CD3 CELSR1 GRHL3 MESP2 MNX1 NF1
5	skeleton	MP:0005390	10	C2CD3 CELSR1 GRHL3 HES7 MESP2 MNX1
6	neoplasm	MP:0002006	9.91	AFP GRHL3 NF1 NOTCH3 PTGDS SHH
7	mortality/aging	MP:0010768	9.77	C2CD3 CELSR1 GRHL3 HES7 MESP2 MNX1
8	integument	MP:0010771	9.32	C2CD3 CELSR1 GRHL3 MESP2 MTHFR NF1

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Drugs & Therapeutics for Meningocele

Drugs for Meningocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Acetylcholine

Approved, Investigational

Phase 4

51-84-3

187

Oxybutynin

Approved, Investigational

Phase 4

5633-20-5

4634

abobotulinumtoxinA

Phase 4

Botulinum Toxins, Type A

Phase 4

Botulinum Toxins

Phase 4

Cholinergic Agents

Phase 4

Drospirenone

Approved

Phase 3

67392-87-4

68873

Calcium, Dietary

Phase 3

Drospirenone and ethinyl estradiol combination

Phase 3

Diuretics, Potassium Sparing

Phase 3

diuretics

Phase 3

Mineralocorticoids

Phase 3

Mineralocorticoid Receptor Antagonists

Phase 3

Calcium

Nutraceutical

Phase 3

7440-70-2

271

Acetazolamide

Approved, Vet_approved

Phase 2

59-66-5, 1424-27-7

1986

Mycophenolic acid

Approved, Investigational

Phase 2

24280-93-1

446541

Miconazole

Approved, Investigational, Vet_approved

Phase 2

22916-47-8

4189

Clotrimazole

Approved, Vet_approved

Phase 2

23593-75-1

2812

Carbonic Anhydrase Inhibitors

Phase 2

Anticonvulsants

Phase 2

Antirheumatic Agents

Phase 2

Calcineurin Inhibitors

Phase 2

Cyclosporins

Phase 2

Antifungal Agents

Phase 2

Antilymphocyte Serum

Phase 2

Thymoglobulin

Phase 2

Antitubercular Agents

Phase 2

Immunosuppressive Agents

Phase 2

Dermatologic Agents

Phase 2

Immunologic Factors

Phase 2

Antibiotics, Antitubercular

Phase 1, Phase 2

Analgesics

Phase 1, Phase 2

Inositol

Approved, Investigational, Withdrawn

Phase 1

87-89-8

Cefoxitin

Approved

35607-66-0

441199

Cefotaxime

Approved

63527-52-6

5742673 456256

Rifampicin

Approved

13292-46-1

135512673 5381226 135900090

Nitrous oxide

Approved, Vet_approved

10024-97-2

948

Pamidronic acid

Approved

40391-99-9

4674

Metformin

Approved

1115-70-4, 657-24-9

4091

Mometasone furoate

Approved, Investigational, Vet_approved

83919-23-7

4240 441336

Caffeine

Approved

58-08-2

2519

Atosiban

Approved, Investigational

90779-69-4

21183636 5311010

Terbutaline

Approved

23031-25-6

5403

Benzocaine

Approved, Investigational

1994-09-7, 94-09-7

2337

Tannic acid

Approved

1401-55-4

16129878 16129778

Pyrantel

Approved, Vet_approved

15686-83-6

Cholecalciferol

Approved, Nutraceutical, Vet_approved

67-97-0, 1406-16-2

5280795 10883523

Bisphenol A

Experimental

80-05-7

6623

Imidacloprid

Vet_approved

105827-78-9

86418

Insulin, Globin Zinc

Interventional clinical trials:

(show top 50) (show all 132)

#	Name	Status	NCT ID	Phase	Drugs
1	Phase 4 Study of the Effect of Botulinum-A Toxin Injected in Neurogenic Overactive Bladders of Children Born With Myelomeningocele	Unknown status	NCT00175123	Phase 4	Botulinum A toxin
2	Multi-Center, Randomized, Double-Blind Active-Controlled, Parallel Group Study to Investigate Plasma Folate, Red Blood Cell Folate and Homocysteine Levels During a 24 Week Oral Administration of an OC Containing Folate Compared to OC Alone	Completed	NCT00468481	Phase 3	Drospirenone/Ethinylestradiol/Methyltetrahydrofolate;Drospirenone/Ethinylestradiol (Yaz)
3	A Randomized, Double-Blind, Two-Part, Parallel-Group, Comparative Study to Evaluate Blood Folate Levels in Women Taking an Oral Contraceptive With and Without Folic Acid	Withdrawn	NCT00301587	Phase 3	Norgestimate-ethinyl estradiol, with or without folic acid
4	Evaluating the Effect of Acetazolamide Administration and Prone Positioning Following Lumbosacral Spinal Surgery in Preventing Cerebro Spinal Fluid Leakage and Collection and Wound Dehiscence in Children.	Unknown status	NCT01867268	Phase 2	Acetazolamide
5	Lumbar to Sacral Ventral Nerve Re-Routing	Completed	NCT00378664	Phase 2
6	Coping Skills Training (CST) for Children With Chronic Health Conditions: An Extension From Children With Diabetes to Children With Rheumatologic Conditions, Epilepsy, Spina Bifida, and Asthma	Completed	NCT00359775	Phase 2
7	Post Transplant Infusion of Allogeneic Cytokine Induced Killer Cells as Consolidative Therapy After Non-Myeloablative Allogeneic Transplantation in Patients With Myelodysplasia or Myeloproliferative Disorders	Completed	NCT01392989	Phase 2	CIK cells;Cyclosporine;Mycophenolate Mofetil;Thymoglobulin
8	The Impact of Self-Management With Probiotics on Urinary Symptoms and the Urine Microbiome in Individuals With Spinal Cord Injury (SCI) and Spina Bifida (SB)"	Completed	NCT02748317	Phase 2	Lactobacillus rhamnosus GG
9	The Impact of Self-Management With Probiotics on Urinary Symptoms and the Urine Microbiome in Individuals With Spinal Cord Injury (SCI) and Spina Bifida (SB)	Completed	NCT02748356	Phase 2	Lactobacillus
10	Phase II Pilot Randomized-Controlled Trial for the Investigation of the Preliminary Efficacy of Surgical Sectioning of the Filum Terminale in Treating Occult Tethered Cord Syndrome Patients	Recruiting	NCT05163899	Phase 2
11	Phase 1/2a Trial of Placental Mesenchymal Stem Cells for Repair of Fetal Myelomeningocele	Recruiting	NCT04652908	Phase 1, Phase 2
12	An Open-Label Multicenter Study of Augmentation Cystoplasty Using an Autologous Neo-Bladder Construct in Subjects With Spina Bifida	Terminated	NCT00419120	Phase 2
13	Probiotics Improvement of Gastrointestinal and Genitourinary Health in Girls With Spina Bifida (H-23245)	Withdrawn	NCT00767988	Phase 2
14	Prevention of Neural Tube Defects by Inositol in Conjunction With Folic Acid (PONTI Study)	Completed	NCT00452829	Phase 1	Folic Acid and inositol;Folic acid and placebo
15	Autologous Bone Marrow Mononuclear Cell Administration in the Treatment of Neurologic Sequela in Children With Spina Bifida	Completed	NCT05472428	Phase 1
16	Study to Compare 2 Minimally Invasive Fetal Neural Tube Defect Repair Techniques: Repair Using Durepair Patch vs. Repair Without Durepair Patch	Active, not recruiting	NCT03794011	Phase 1
17	Minimally Invasive Fetal Neural Tube Defect Repair Study	Active, not recruiting	NCT02230072	Phase 1
18	Knowledge and Follow-up of Vitamin B9 Supplementation Recommendations for Women in the Periconceptional Period to Prevent Neural Tube Closure Defects: a Study Conducted With Health Professionnals and Women Who Have Just Given Birth in Rennes CHU.	Unknown status	NCT04195542
19	Assessment of Functional Independence and Quality of Life in Italian Population of Adolescents With Spina Bifid	Unknown status	NCT00966927
20	Fecal Microbium Change in Pediatric Patients With Spina Bifida: Prospective Case-control Study	Unknown status	NCT04186130
21	Incidence of Pregnancies and Births With Spina Bifida in Denmark in 2008-2014	Unknown status	NCT02685813
22	Powder Topical Rifampicin on Reducing Infections After Neural Tube Defect Surgery in Infants	Unknown status	NCT03198819		Local Rifampisin and İnrtravenous cefotaxime
23	Open Spina Bifida Fetoscopic Repair Project	Unknown status	NCT03562286
24	Interrater and Intrarater Reliability of Infant Motor Profile: Assessing Motor Profiles of Risky Infants	Unknown status	NCT03188107
25	The Spina Bifida Research Resource	Unknown status	NCT00031122
26	Spina Bifida in Daily Life: an Exploratory Study	Unknown status	NCT03148301
27	Anorectal Dysfunction in Patients Suffering From Spina Bifida : From Clinic to Neuro-epithelial Function	Unknown status	NCT02440984
28	Genetics of Neural Tubes Defects	Unknown status	NCT01253746
29	Changes in the Cuff Pressure in Infants in the Absence of Nitrous Oxide	Unknown status	NCT03088761
30	Qualitative In-depth Interviews With Women and Their Partners Concerning the Acceptability of Fetal Surgery	Unknown status	NCT03788122
31	The Effects of Physical Therapy Associated With Photobiomodulation on Functional Performance in Children With Low Lumbar and Sacral Myelomeningocele - A Randomized, Blinded Clinical Trial.	Unknown status	NCT04425330
32	EVALUATION OF THE SENSORY-MOTOR RESPONSE IN PATIENTS WITH MYELOMENINGOCELE FOLLOWING TREATMENT WITH PHOTOBIOMODULATION	Unknown status	NCT04035863
33	NSC Assistive Technology Research: Reciprocating Gait Orthoses for Paraplegia Patients	Unknown status	NCT02227407
34	Free Style Pedicled Perforators Propellers Flaps for Meningomylocele Defects Reconstruction With Sequential Advance in Perforators Dissection	Completed	NCT05188300
35	An Audit of the Posterior Fossa Characterization in Open Spina Bifida Based on Tertiary Center Experience	Completed	NCT03544970
36	The LETS Study: A Longitudinal Evaluation of Transition Services	Completed	NCT00975338
37	Myelomeningocele Repair Randomized Trial	Completed	NCT00060606
38	Prevention of Post Operative Bone Loss in Children	Completed	NCT00655681		pamidronate
39	The Effectiveness of Participation-focused Interventions on Body Functions of Youth With Physical Disabilities: An Interrupted Time Series Design	Completed	NCT03851107
40	Impact of Prenatal Correction of Spina Bifida Using Fetoscopy and the SAFER Technique on Long-term Neurodevelopment.	Completed	NCT04356703
41	Parental Perspectives of Using Modified Toy Cars on the Social Interactions of Preschool Children With Mobility Impairments.	Completed	NCT02682043
42	Urological and Renal Disease Engaging Adolescents in Adherence Collaborative Trial	Completed	NCT03045276
43	Is Neutrophil to Lymphocyte Ratio a Prognostic Factor of Sepsis in Newborns With Operated Neural Tube Defects?	Completed	NCT04135274
44	Metformin in Children With Motor Deficit	Completed	NCT00720161		Metformin;placebo
45	3D-printed Module-assisted Minimally Invasive Lumbar Pedicle Screw Placement: a Retrospective, Self-controlled, Open-label Clinical Trial	Completed	NCT02970578
46	A Randomized Exercise Trial for Wheelchair Users	Completed	NCT00866112
47	Efficacy of Weekly Versus Daily Folic Acid Supplementation	Completed	NCT00394862		multivitamin
48	Retrograde Colonic Irrigation to Manage Spina Bifida Functional Digestive Sequelae: a Multicenter, Prospective, Randomized Controlled Trial	Completed	NCT02361450
49	Medication Management Among Individuals With Neurodevelopmental Disabilities	Completed	NCT03121651
50	A Peer E-mentoring Intervention to Improve Transition to Employment for Youth With Physical Disabilities	Completed	NCT02522507

Search NIH Clinical Center for Meningocele

Cochrane evidence based reviews: meningocele

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Genetic Tests for Meningocele

Genetic tests related to Meningocele:

#	Genetic test	Affiliating Genes
1	Meningocele ²⁸
2	Isolated Spina Bifida ²⁸

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Anatomical Context for Meningocele

Organs/tissues related to Meningocele:

MalaCards : Spinal Cord, Bone Marrow, Bone, Brain, Prostate, Neutrophil, Skin

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Publications for Meningocele

Articles related to Meningocele:

(show top 50) (show all 10331)

#	Title	Authors	PMID	Year
1	Prenatal diagnosis of sacrococcygeal teratoma with constitutional partial monosomy 7q/trisomy 2p. ⁵³ ⁶²	Le Caignec C...Rival JM	14663834	2003
2	Perspective on inflammatory cytokines in open spinal dysraphism. ⁶²	Knerlich-Lukoschus F	35900420	2023
3	Evaluating the role for regional analgesia in children with spina bifida: a retrospective observational study comparing the efficacy of regional versus systemic analgesia protocols following major urological surgery. ⁶²	Moore RP...PURSUE Study Group	36167478	2023
4	Detection rates of a national fetal anomaly screening programme: A national cohort study. ⁶²	Aldridge N...Stevens S	36054171	2023
5	Aetiology and diagnostics of paediatric hydrocephalus across Africa: a systematic review and meta-analysis. ⁶²	Aukrust CG...Eide PK	36400085	2022
6	Importance of urodynamic evaluation of bladder function after secondary untethering in spina bifida patients: single center experience of 30 years. ⁶²	Ciesla L...Lingnau A	36454325	2022
7	Risk of neural tube defects according to maternal body mass index: a systematic review and meta-analysis. ⁶²	Vena F...Giancotti A	34219595	2022
8	Folic acid fortification of flour to prevent neural tube defects in Europe - A position statement by the European Board and college of obstetrics and gynaecology (EBCOG). ⁶²	Petch S...Mahmood T	36332537	2022
9	A global update on the status of prevention of folic acid-preventable spina bifida and anencephaly in year 2020: 30-Year anniversary of gaining knowledge about folic acid's prevention potential for neural tube defects. ⁶²	Kancherla V...Oakley GP	36345648	2022
10	Analysis of DNMT1 gene variants in progression of neural tube defects-an in silico to in vitro approach. ⁶²	Sadhukhan S...Das M	36394275	2022
11	Inhibition of retinoic acid signaling impairs cranial and spinal neural tube closure in mice lacking the Grainyhead-like 3 transcription factor. ⁶²	Deng Z...Jane SM	36283337	2022
12	Brain Doppler abnormalities in fetuses with open spina bifida. ⁶²	Martinez-Rodriguez M...Cruz-Martinez R	34470130	2022
13	Prevalence and risk factors for scoliosis in adults with closed and open spina bifida: A large, cross-sectional study. ⁶²	Cacioppo M...Bonan I	35717001	2022
14	Weight Status of Children Participating in the National Spina Bifida Patient Registry. ⁶²	Polfuss M...Sawin KJ	36416007	2022
15	Health Care for Adults With Cerebral Palsy and Spina Bifida-Must It Be so Difficult? ⁶²	Brandenburg JE	36464460	2022
16	Subsequent pregnancy outcomes after open in utero spina bifida repair. ⁶²	Zepf J...Ochsenbein-Kolble N	36455544	2022
17	Solo and Partnered Sexual Behavior Among an International Sample of Adults With Spina Bifida. ⁶²	Hensel DJ...Szymanski KM	36216747	2022
18	Neurodevelopmental Implications on Urological Self-Management Among People Living with Spina Bifida: A Practical Guide for Urology Providers. ⁶²	Gandy K...Castillo J	36473589	2022
19	The Association of Health Literacy with Health-Related Quality of Life in Youth and Young Adults with Spina Bifida: A Cross-Sectional Study. ⁶²	Rague JT...Chu DI	35970239	2022
20	Late diagnosis of dorsolumbar lipomyelomeningocele with tethered cord in a middle aged adult: A case report from Nepal. ⁶²	Aryal S...Deo S	36189164	2022
21	Prenatal intracranial hypotension syndrome: new insights into the mechanisms of fenestration of septi pellucidi and ventriculomegaly in fetuses with open spinal dysraphism. ⁶²	Sepulveda F...Sepulveda W	34074204	2022
22	A rare incidental finding of an isolated S1 butterfly vertebra: A case report. ⁶²	Bhattarai V...Acharya S	36212764	2022
23	Sonographic spectrum and postnatal outcomes of early-onset versus late-onset fetal cerebral ventriculomegaly. ⁶²	Bhatia A...Yeo GSH	33292033	2022
24	[Analysis of anorectal manometry data in central and peripheral neurological deseases: Review of the literature]. ⁶²	Essid D...Amarenco G	36030152	2022
25	Potentially Preventable Hospitalizations Among Adults With Pediatric-Onset Disabilities. ⁶²	Mahmoudi E...Peterson MD	36336517	2022
26	Developing clinical algorithm for identifying acute lumbar spondylolysis in elementary school children - Classification and regression tree analysis. ⁶²	Aoyagi M...Tumilty S	35343399	2022
27	Association of ethnicity and adaptive functioning with health-related quality of life in pediatric myelomeningocele. ⁶²	Kamath NN...Treble-Barna A	36442218	2022
28	The art of introducing clean intermittent catheterization: How families respond and adapt: A qualitative study. ⁶²	Bauer SB...Shimmel A	36352775	2022
29	[Repair Surgery of Myelomeningocele]. ⁶²	Kurihara J	36426520	2022
30	The incidence of congenital lumbosacral malformations in young male Turkish military school candidates population. ⁶²	Fidan F...Veizi E	34391615	2022
31	Wnt/planar cell polarity signaling controls morphogenetic movements of gastrulation and neural tube closure. ⁶²	Shi DL	36369349	2022
32	Postnatal Surgical Correction of Myelomeningoceles: Pre- and Intraoperative Risk Factors Associated with Postoperative Neurological Outcomes. ⁶²	Acosta-Medina E...Ordonez-Rubiano EG	36410703	2022
33	Long-term Reoperation Rates After Open Versus Minimally Invasive Spine Surgery for Degenerative Lumbar Disease: Five Year Follow-Up of 2,130 Patients. ⁶²	Ramanathan S...Fahim DK	36442783	2022
34	Long-term results of artificial urinary sphincter implantation for urinary incontinence due to intrinsic sphincter deficiency in children. ⁶²	Paret F...Perrouin-Verbe MA	36434815	2022
35	Tethered cord release in patients after open fetal myelomeningocele closure: intraoperative neuromonitoring data and patient outcomes. ⁶²	Flanders TM...Heuer GG	36380051	2022
36	Electrodiagnosis has a potential to identify neural damage in asymptomatic infants with closed spinal dysraphism. ⁶²	Park M...Shin HI	36445470	2022
37	Association between ambulatory skills and diffusion tensor imaging of corpus callosal white matter in infants with spina bifida. ⁶²	Sanz Cortes M...Meoded A	35638229	2022
38	Nurse-led eHealth transition care program for adolescents with spina bifida: A feasibility and acceptability study. ⁶²	Choi EK...Yun H	35939952	2022
39	Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida. ⁶²	Haug U...Onken M	36401747	2022
40	The role of neurosurgeons in global public health: the case of folic acid fortification of staple foods to prevent spina bifida. ⁶²	Shlobin NA...Global Alliance for the Prevention of Spina Bifida-F (GAPSBiF)	36334286	2022
41	Follow-up of brace-treated scoliosis in children with cerebral palsy and spina bifida. ⁶²	Eek MN...Romberg K	36442215	2022
42	Exploratory study of the provision of academic and health-related accommodations to transition-age adolescents and emerging adults with spina bifida. ⁶²	Betz CL...Van Speybroeck A	36442216	2022
43	Primary vs patch-based skin closure for in-utero spina bifida repair. ⁶²	Fishel Bartal M...Papanna R	35751885	2022
44	Working memory and cognitive flexibility predict growth trajectories of sluggish cognitive tempo in youth with spina bifida. ⁶²	Smith ZR...Holmbeck GN	35196965	2022
45	Impact of AREDF-UA during and after fetal spina bifida repair on postoperative, neonatal and 2-year neurodevelopmental outcome. ⁶²	Ruegg L...Ochsenbein-Kolble N	36357943	2022
46	Information needs of parents of children with congenital anomalies across Europe: a EUROlinkCAT survey. ⁶²	Marcus E...Morris JK	36368959	2022
47	Conservative treatment of non-healing plantar skin ulcer complicated by infection and fistula in congenital clubfoot. A case report. ⁶²	Palombi L...Palombi M	36448360	2022
48	Cannabidiol impairs neural tube closure in mouse whole embryo culture. ⁶²	Gheasuddin Y...Galea GL	35416425	2022
49	Prenatal diagnosis and pregnancy outcome of major structural anomalies detectable in the first trimester: A population-based cohort study in the Netherlands. ⁶²	Bardi F...Bakker MK	35821640	2022
50	Education and employment as young adults living with spina bifida transition to adulthood in the USA: A study of the National Spina Bifida Patient Registry. ⁶²	Liu T...Riley C	36385606	2022

Sources

Genes for Meningocele

Genes related to Meningocele (0 elite genes):

(show all 21)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	NOTCH3	Notch Receptor 3	Protein Coding	22.76	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
2	MNX1	Motor Neuron And Pancreas Homeobox 1	Protein Coding	17.22	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	14663834
3	VANGL1	VANGL Planar Cell Polarity Protein 1	Protein Coding	12.73	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
4	NF1	Neurofibromin 1	Protein Coding	6.92	DISEASES inferred ¹⁴
5	SEL1L2	SEL1L2 Adaptor Subunit Of ERAD E3 Ligase	Protein Coding	6.13	DISEASES inferred ¹⁴
6	C14orf119	Chromosome 14 Open Reading Frame 119	Protein Coding	5.66	DISEASES inferred ¹⁴
7	AFP	Alpha Fetoprotein	Protein Coding	5.63	DISEASES inferred ¹⁴
8	SNORA70B	Small Nucleolar RNA, H/ACA Box 70B	RNA Gene	5.5	DISEASES inferred ¹⁴
9	HES7	Hes Family BHLH Transcription Factor 7	Protein Coding	5.37	DISEASES inferred ¹⁴
10	TMEM67	Transmembrane Protein 67	Protein Coding	5.3	DISEASES inferred ¹⁴
11	PTGDS	Prostaglandin D2 Synthase	Protein Coding	5.28	DISEASES inferred ¹⁴
12	MESP2	Mesoderm Posterior BHLH Transcription Factor 2	Protein Coding	5.16	DISEASES inferred ¹⁴
13	SMCO1	Single-Pass Membrane Protein With Coiled-Coil Domains 1	Protein Coding	5.13	DISEASES inferred ¹⁴
14	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	5.08	DISEASES inferred ¹⁴
15	CELSR1	Cadherin EGF LAG Seven-Pass G-Type Receptor 1	Protein Coding	5.02	DISEASES inferred ¹⁴
16	TCTE1	T-Complex-Associated-Testis-Expressed 1	Protein Coding	5.01	DISEASES inferred ¹⁴
17	USP34	Ubiquitin Specific Peptidase 34	Protein Coding	4.93	DISEASES inferred ¹⁴
18	C2CD3	C2 Domain Containing 3 Centriole Elongation Regulator	Protein Coding	4.89	DISEASES inferred ¹⁴
19	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	4.89	DISEASES inferred ¹⁴
20	GRHL3	Grainyhead Like Transcription Factor 3	Protein Coding	4.83	DISEASES inferred ¹⁴
21	FZD6	Frizzled Class Receptor 6	Protein Coding	4.82	DISEASES inferred ¹⁴

Sources

Variations for Meningocele

Sources

Expression for Meningocele

Search GEO for disease gene expression data for Meningocele.

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Pathways for Meningocele

Pathways related to Meningocele according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Wnt / Hedgehog / Notch ³	11.18	VANGL1 SHH NOTCH3 AFP
2	Gene regulatory network modelling somitogenesis ⁷⁴ Show member pathways Somitogenesis in the context of spondylocostal dysostosis ⁷⁴	10.26	MESP2 HES7

Sources

GO Terms for Meningocele

Biological processes related to Meningocele according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of proteolysis	GO:0030162	9.56	SHH C2CD3
2	central nervous system development	GO:0007417	9.56	SHH MNX1 GRHL3 CELSR1
3	planar cell polarity pathway involved in neural tube closure	GO:0090179	9.33	GRHL3 CELSR1
4	pattern specification process	GO:0007389	9.02	SHH GRHL3 C2CD3