MCID: MNN007
MIFTS: 50

Meningocele

Categories: Fetal diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Meningocele

MalaCards integrated aliases for Meningocele:

Name: Meningocele 11 19 75 28 53 43 14 71 75
Isolated Spina Bifida 19 58 28
Congenital Meningocele 71
Spinal Meningocele 71
Spinal Dysraphism 19
Spina Bifida 19
Rachischisis 19
Cleft Spine 19
Open Spine 19

Characteristics:


Inheritance:

Isolated Spina Bifida: Multigenic/multifactorial 58

Prevelance:

Isolated Spina Bifida: 1-5/10000 (Europe, Europe, France, United States, Belgium, Croatia, Denmark, France, Germany, Hungary, Ireland, Italy, Malta, Netherlands, Norway, Poland, Portugal, Switzerland, United Kingdom, Ukraine) 1-9/100000 (Austria, Spain) 58

Age Of Onset:

Isolated Spina Bifida: Infancy,Neonatal 58

Classifications:

Orphanet: 58  
Rare neurological diseases
Developmental anomalies during embryogenesis


External Ids:

Disease Ontology 11 DOID:1088
MeSH 43 D008588
SNOMED-CT 68 268308005
MESH via Orphanet 44 D016135
UMLS via Orphanet 72 C0080178
Orphanet 58 ORPHA823
UMLS 71 C0009730 C0025299 C1261470

Summaries for Meningocele

Orphanet: 58 A group of rare neural tube defect disorders characterized by improper closure of the spinal column during embryonal development, not associated with other major congenital malformations nor ventriculomegaly. The extent of the closure defect may vary, ranging from spina bifida occulta, in which the site of the lesion is not exposed (e.g. an isolated posterior vertebral arch defect), to spina bifida aperta, in which the lesion may be conformed of proturding spinal cord and meninges (myelomeningocele) or meninges exposure only (meningocele), with or without a proturding sac at the site of the lesion, to the most severe defect which includes total exposure of the spinal cord along its full length (rachischisis). Depending on the type, size and site of the defect, severe morbidity, typically inlcuding motor, sensory and sphincter dysfunction, and mortality may be associated. Spina bifida occulta may be asymptomatic.

MalaCards based summary: Meningocele, also known as isolated spina bifida, is related to lateral meningocele syndrome and cervical spina bifida aperta. An important gene associated with Meningocele is NOTCH3 (Notch Receptor 3), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Gene regulatory network modelling somitogenesis. The drugs Acetylcholine and Oxybutynin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and bone, and related phenotypes are nervous system and limbs/digits/tail

Disease Ontology: 11 A spina bifida that is characterized by herniation of the meninges between the vertebrae.

GARD: 19 Protrusion of the meninges through a defect of the vertebral column.

Wikipedia: 75 Spina bifida (Latin for 'split spine'; SB) is a birth defect in which there is incomplete closing of the... more...

Related Diseases for Meningocele

Diseases in the Meningocele family:

Posterior Meningocele

Diseases related to Meningocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 786)
# Related Disease Score Top Affiliating Genes
1 lateral meningocele syndrome 33.0 NOTCH3 MESP2 HES7
2 cervical spina bifida aperta 32.4 VANGL1 MTHFR
3 spina bifida occulta 32.4 VANGL1 MTHFR HES7 CELSR1 C2CD3
4 lumbosacral spina bifida cystica 32.2 VANGL1 MTHFR
5 cervical spina bifida cystica 32.2 VANGL1 MTHFR
6 total spina bifida aperta 32.2 VANGL1 MTHFR
7 cervicothoracic spina bifida aperta 32.2 VANGL1 MTHFR
8 lumbosacral spina bifida aperta 32.2 VANGL1 MTHFR
9 thoracolumbosacral spina bifida aperta 32.2 VANGL1 MTHFR
10 upper thoracic spina bifida aperta 32.2 VANGL1 MTHFR
11 total spina bifida cystica 32.2 VANGL1 MTHFR
12 thoracolumbosacral spina bifida cystica 32.2 VANGL1 MTHFR
13 cervicothoracic spina bifida cystica 32.1 VANGL1 MTHFR
14 upper thoracic spina bifida cystica 32.1 VANGL1 MTHFR
15 cloacal exstrophy 31.9 SHH MNX1
16 currarino syndrome 31.7 VANGL1 SHH MNX1
17 sacral defect with anterior meningocele 31.4 VANGL1 TCTE1 SHH MNX1 MESP2 HES7
18 myelomeningocele 31.2 VANGL1 MTHFR GRHL3 CELSR1
19 tethered spinal cord syndrome 30.8 VANGL1 MNX1 CELSR1 AFP
20 intracranial hypotension 30.4 PTGDS MTHFR
21 neural tube defects 30.3 VANGL1 SHH NF1 MTHFR MNX1 MESP2
22 teratoma 30.2 SHH MNX1 AFP
23 pulsating exophthalmos 30.2 PTGDS NF1
24 hajdu-cheney syndrome 30.0 NOTCH3 MESP2 HES7
25 spondylocostal dysostosis, autosomal recessive 29.9 MESP2 HES7
26 spondylocostal dysostosis 1, autosomal recessive 29.9 MESP2 HES7
27 cystic teratoma 29.9 MNX1 AFP
28 obstructive hydrocephalus 29.8 SHH NF1 AFP
29 dysostosis 29.8 SHH MESP2 HES7
30 spondylocostal dysostosis 29.8 NOTCH3 MESP2 HES7
31 adams-oliver syndrome 29.8 NOTCH3 MESP2 HES7
32 spondylocostal dysostosis 5 29.7 MESP2 HES7
33 omphalocele 29.6 SHH MNX1 AFP
34 cleft lip 28.9 SHH MTHFR GRHL3
35 anencephaly 28.9 VANGL1 SHH MTHFR GRHL3 CELSR1 AFP
36 orofacial cleft 28.9 SHH MTHFR GRHL3 C2CD3
37 split-hand with obstructive uropathy, spina bifida, and diaphragmatic defects 11.8
38 spina bifida aperta 11.8
39 spina bifida hypospadias 11.8
40 anencephaly and spina bifida x-linked 11.4
41 kasznica carlson coppedge syndrome 11.4
42 schisis association 11.3
43 acrofacial dysostosis, catania type 11.3
44 blepharocheilodontic syndrome 1 11.3
45 hypertrichosis, congenital anterior cervical, with peripheral sensory and motor neuropathy 11.3
46 male pseudohermaphroditism/mental retardation syndrome, verloes type 11.3
47 camptodactyly syndrome, guadalajara, type iii 11.3
48 acrodysplasia scoliosis 11.3
49 thakker-donnai syndrome 11.3
50 medeira-dennis-donnai syndrome 11.3

Graphical network of the top 20 diseases related to Meningocele:



Diseases related to Meningocele

Symptoms & Phenotypes for Meningocele

MGI Mouse Phenotypes related to Meningocele:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.18 C2CD3 CELSR1 GRHL3 MESP2 MNX1 MTHFR
2 limbs/digits/tail MP:0005371 10.07 C2CD3 CELSR1 GRHL3 HES7 MESP2 MTHFR
3 embryo MP:0005380 10.02 C2CD3 CELSR1 GRHL3 HES7 MESP2 NF1
4 cellular MP:0005384 10 C2CD3 CELSR1 GRHL3 MESP2 MNX1 NF1
5 skeleton MP:0005390 10 C2CD3 CELSR1 GRHL3 HES7 MESP2 MNX1
6 neoplasm MP:0002006 9.91 AFP GRHL3 NF1 NOTCH3 PTGDS SHH
7 mortality/aging MP:0010768 9.77 C2CD3 CELSR1 GRHL3 HES7 MESP2 MNX1
8 integument MP:0010771 9.32 C2CD3 CELSR1 GRHL3 MESP2 MTHFR NF1

Drugs & Therapeutics for Meningocele

Drugs for Meningocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
2
Oxybutynin Approved, Investigational Phase 4 5633-20-5 4634
3
abobotulinumtoxinA Phase 4
4 Botulinum Toxins, Type A Phase 4
5 Botulinum Toxins Phase 4
6 Cholinergic Agents Phase 4
7
Drospirenone Approved Phase 3 67392-87-4 68873
8 Calcium, Dietary Phase 3
9 Drospirenone and ethinyl estradiol combination Phase 3
10 Diuretics, Potassium Sparing Phase 3
11 diuretics Phase 3
12 Mineralocorticoids Phase 3
13 Mineralocorticoid Receptor Antagonists Phase 3
14
Calcium Nutraceutical Phase 3 7440-70-2 271
15
Acetazolamide Approved, Vet_approved Phase 2 59-66-5, 1424-27-7 1986
16
Mycophenolic acid Approved, Investigational Phase 2 24280-93-1 446541
17
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
18
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
19 Carbonic Anhydrase Inhibitors Phase 2
20 Anticonvulsants Phase 2
21 Antirheumatic Agents Phase 2
22 Calcineurin Inhibitors Phase 2
23 Cyclosporins Phase 2
24 Antifungal Agents Phase 2
25 Antilymphocyte Serum Phase 2
26 Thymoglobulin Phase 2
27 Antitubercular Agents Phase 2
28 Immunosuppressive Agents Phase 2
29 Dermatologic Agents Phase 2
30 Immunologic Factors Phase 2
31 Antibiotics, Antitubercular Phase 1, Phase 2
32 Analgesics Phase 1, Phase 2
33
Inositol Approved, Investigational, Withdrawn Phase 1 87-89-8
34
Cefoxitin Approved 35607-66-0 441199
35
Cefotaxime Approved 63527-52-6 5742673 456256
36
Rifampicin Approved 13292-46-1 135512673 5381226 135900090
37
Nitrous oxide Approved, Vet_approved 10024-97-2 948
38
Pamidronic acid Approved 40391-99-9 4674
39
Metformin Approved 1115-70-4, 657-24-9 4091
40
Mometasone furoate Approved, Investigational, Vet_approved 83919-23-7 4240 441336
41
Caffeine Approved 58-08-2 2519
42
Atosiban Approved, Investigational 90779-69-4 21183636 5311010
43
Terbutaline Approved 23031-25-6 5403
44
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
45
Tannic acid Approved 1401-55-4 16129878 16129778
46
Pyrantel Approved, Vet_approved 15686-83-6
47
Cholecalciferol Approved, Nutraceutical, Vet_approved 67-97-0, 1406-16-2 5280795 10883523
48
Bisphenol A Experimental 80-05-7 6623
49
Imidacloprid Vet_approved 105827-78-9 86418
50 Insulin, Globin Zinc

Interventional clinical trials:

(show top 50) (show all 132)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study of the Effect of Botulinum-A Toxin Injected in Neurogenic Overactive Bladders of Children Born With Myelomeningocele Unknown status NCT00175123 Phase 4 Botulinum A toxin
2 Multi-Center, Randomized, Double-Blind Active-Controlled, Parallel Group Study to Investigate Plasma Folate, Red Blood Cell Folate and Homocysteine Levels During a 24 Week Oral Administration of an OC Containing Folate Compared to OC Alone Completed NCT00468481 Phase 3 Drospirenone/Ethinylestradiol/Methyltetrahydrofolate;Drospirenone/Ethinylestradiol (Yaz)
3 A Randomized, Double-Blind, Two-Part, Parallel-Group, Comparative Study to Evaluate Blood Folate Levels in Women Taking an Oral Contraceptive With and Without Folic Acid Withdrawn NCT00301587 Phase 3 Norgestimate-ethinyl estradiol, with or without folic acid
4 Evaluating the Effect of Acetazolamide Administration and Prone Positioning Following Lumbosacral Spinal Surgery in Preventing Cerebro Spinal Fluid Leakage and Collection and Wound Dehiscence in Children. Unknown status NCT01867268 Phase 2 Acetazolamide
5 Lumbar to Sacral Ventral Nerve Re-Routing Completed NCT00378664 Phase 2
6 Coping Skills Training (CST) for Children With Chronic Health Conditions: An Extension From Children With Diabetes to Children With Rheumatologic Conditions, Epilepsy, Spina Bifida, and Asthma Completed NCT00359775 Phase 2
7 Post Transplant Infusion of Allogeneic Cytokine Induced Killer Cells as Consolidative Therapy After Non-Myeloablative Allogeneic Transplantation in Patients With Myelodysplasia or Myeloproliferative Disorders Completed NCT01392989 Phase 2 CIK cells;Cyclosporine;Mycophenolate Mofetil;Thymoglobulin
8 The Impact of Self-Management With Probiotics on Urinary Symptoms and the Urine Microbiome in Individuals With Spinal Cord Injury (SCI) and Spina Bifida (SB)" Completed NCT02748317 Phase 2 Lactobacillus rhamnosus GG
9 The Impact of Self-Management With Probiotics on Urinary Symptoms and the Urine Microbiome in Individuals With Spinal Cord Injury (SCI) and Spina Bifida (SB) Completed NCT02748356 Phase 2 Lactobacillus
10 Phase II Pilot Randomized-Controlled Trial for the Investigation of the Preliminary Efficacy of Surgical Sectioning of the Filum Terminale in Treating Occult Tethered Cord Syndrome Patients Recruiting NCT05163899 Phase 2
11 Phase 1/2a Trial of Placental Mesenchymal Stem Cells for Repair of Fetal Myelomeningocele Recruiting NCT04652908 Phase 1, Phase 2
12 An Open-Label Multicenter Study of Augmentation Cystoplasty Using an Autologous Neo-Bladder Construct in Subjects With Spina Bifida Terminated NCT00419120 Phase 2
13 Probiotics Improvement of Gastrointestinal and Genitourinary Health in Girls With Spina Bifida (H-23245) Withdrawn NCT00767988 Phase 2
14 Prevention of Neural Tube Defects by Inositol in Conjunction With Folic Acid (PONTI Study) Completed NCT00452829 Phase 1 Folic Acid and inositol;Folic acid and placebo
15 Autologous Bone Marrow Mononuclear Cell Administration in the Treatment of Neurologic Sequela in Children With Spina Bifida Completed NCT05472428 Phase 1
16 Study to Compare 2 Minimally Invasive Fetal Neural Tube Defect Repair Techniques: Repair Using Durepair Patch vs. Repair Without Durepair Patch Active, not recruiting NCT03794011 Phase 1
17 Minimally Invasive Fetal Neural Tube Defect Repair Study Active, not recruiting NCT02230072 Phase 1
18 Knowledge and Follow-up of Vitamin B9 Supplementation Recommendations for Women in the Periconceptional Period to Prevent Neural Tube Closure Defects: a Study Conducted With Health Professionnals and Women Who Have Just Given Birth in Rennes CHU. Unknown status NCT04195542
19 Assessment of Functional Independence and Quality of Life in Italian Population of Adolescents With Spina Bifid Unknown status NCT00966927
20 Fecal Microbium Change in Pediatric Patients With Spina Bifida: Prospective Case-control Study Unknown status NCT04186130
21 Incidence of Pregnancies and Births With Spina Bifida in Denmark in 2008-2014 Unknown status NCT02685813
22 Powder Topical Rifampicin on Reducing Infections After Neural Tube Defect Surgery in Infants Unknown status NCT03198819 Local Rifampisin and İnrtravenous cefotaxime
23 Open Spina Bifida Fetoscopic Repair Project Unknown status NCT03562286
24 Interrater and Intrarater Reliability of Infant Motor Profile: Assessing Motor Profiles of Risky Infants Unknown status NCT03188107
25 The Spina Bifida Research Resource Unknown status NCT00031122
26 Spina Bifida in Daily Life: an Exploratory Study Unknown status NCT03148301
27 Anorectal Dysfunction in Patients Suffering From Spina Bifida : From Clinic to Neuro-epithelial Function Unknown status NCT02440984
28 Genetics of Neural Tubes Defects Unknown status NCT01253746
29 Changes in the Cuff Pressure in Infants in the Absence of Nitrous Oxide Unknown status NCT03088761
30 Qualitative In-depth Interviews With Women and Their Partners Concerning the Acceptability of Fetal Surgery Unknown status NCT03788122
31 The Effects of Physical Therapy Associated With Photobiomodulation on Functional Performance in Children With Low Lumbar and Sacral Myelomeningocele - A Randomized, Blinded Clinical Trial. Unknown status NCT04425330
32 EVALUATION OF THE SENSORY-MOTOR RESPONSE IN PATIENTS WITH MYELOMENINGOCELE FOLLOWING TREATMENT WITH PHOTOBIOMODULATION Unknown status NCT04035863
33 NSC Assistive Technology Research: Reciprocating Gait Orthoses for Paraplegia Patients Unknown status NCT02227407
34 Free Style Pedicled Perforators Propellers Flaps for Meningomylocele Defects Reconstruction With Sequential Advance in Perforators Dissection Completed NCT05188300
35 An Audit of the Posterior Fossa Characterization in Open Spina Bifida Based on Tertiary Center Experience Completed NCT03544970
36 The LETS Study: A Longitudinal Evaluation of Transition Services Completed NCT00975338
37 Myelomeningocele Repair Randomized Trial Completed NCT00060606
38 Prevention of Post Operative Bone Loss in Children Completed NCT00655681 pamidronate
39 The Effectiveness of Participation-focused Interventions on Body Functions of Youth With Physical Disabilities: An Interrupted Time Series Design Completed NCT03851107
40 Impact of Prenatal Correction of Spina Bifida Using Fetoscopy and the SAFER Technique on Long-term Neurodevelopment. Completed NCT04356703
41 Parental Perspectives of Using Modified Toy Cars on the Social Interactions of Preschool Children With Mobility Impairments. Completed NCT02682043
42 Urological and Renal Disease Engaging Adolescents in Adherence Collaborative Trial Completed NCT03045276
43 Is Neutrophil to Lymphocyte Ratio a Prognostic Factor of Sepsis in Newborns With Operated Neural Tube Defects? Completed NCT04135274
44 Metformin in Children With Motor Deficit Completed NCT00720161 Metformin;placebo
45 3D-printed Module-assisted Minimally Invasive Lumbar Pedicle Screw Placement: a Retrospective, Self-controlled, Open-label Clinical Trial Completed NCT02970578
46 A Randomized Exercise Trial for Wheelchair Users Completed NCT00866112
47 Efficacy of Weekly Versus Daily Folic Acid Supplementation Completed NCT00394862 multivitamin
48 Retrograde Colonic Irrigation to Manage Spina Bifida Functional Digestive Sequelae: a Multicenter, Prospective, Randomized Controlled Trial Completed NCT02361450
49 Medication Management Among Individuals With Neurodevelopmental Disabilities Completed NCT03121651
50 A Peer E-mentoring Intervention to Improve Transition to Employment for Youth With Physical Disabilities Completed NCT02522507

Search NIH Clinical Center for Meningocele

Cochrane evidence based reviews: meningocele

Genetic Tests for Meningocele

Genetic tests related to Meningocele:

# Genetic test Affiliating Genes
1 Meningocele 28
2 Isolated Spina Bifida 28

Anatomical Context for Meningocele

Organs/tissues related to Meningocele:

MalaCards : Spinal Cord, Bone Marrow, Bone, Brain, Prostate, Neutrophil, Skin

Publications for Meningocele

Articles related to Meningocele:

(show top 50) (show all 10331)
# Title Authors PMID Year
1
Prenatal diagnosis of sacrococcygeal teratoma with constitutional partial monosomy 7q/trisomy 2p. 53 62
14663834 2003
2
Perspective on inflammatory cytokines in open spinal dysraphism. 62
35900420 2023
3
Evaluating the role for regional analgesia in children with spina bifida: a retrospective observational study comparing the efficacy of regional versus systemic analgesia protocols following major urological surgery. 62
36167478 2023
4
Detection rates of a national fetal anomaly screening programme: A national cohort study. 62
36054171 2023
5
Aetiology and diagnostics of paediatric hydrocephalus across Africa: a systematic review and meta-analysis. 62
36400085 2022
6
Importance of urodynamic evaluation of bladder function after secondary untethering in spina bifida patients: single center experience of 30 years. 62
36454325 2022
7
Risk of neural tube defects according to maternal body mass index: a systematic review and meta-analysis. 62
34219595 2022
8
Folic acid fortification of flour to prevent neural tube defects in Europe - A position statement by the European Board and college of obstetrics and gynaecology (EBCOG). 62
36332537 2022
9
A global update on the status of prevention of folic acid-preventable spina bifida and anencephaly in year 2020: 30-Year anniversary of gaining knowledge about folic acid's prevention potential for neural tube defects. 62
36345648 2022
10
Analysis of DNMT1 gene variants in progression of neural tube defects-an in silico to in vitro approach. 62
36394275 2022
11
Inhibition of retinoic acid signaling impairs cranial and spinal neural tube closure in mice lacking the Grainyhead-like 3 transcription factor. 62
36283337 2022
12
Brain Doppler abnormalities in fetuses with open spina bifida. 62
34470130 2022
13
Prevalence and risk factors for scoliosis in adults with closed and open spina bifida: A large, cross-sectional study. 62
35717001 2022
14
Weight Status of Children Participating in the National Spina Bifida Patient Registry. 62
36416007 2022
15
Health Care for Adults With Cerebral Palsy and Spina Bifida-Must It Be so Difficult? 62
36464460 2022
16
Subsequent pregnancy outcomes after open in utero spina bifida repair. 62
36455544 2022
17
Solo and Partnered Sexual Behavior Among an International Sample of Adults With Spina Bifida. 62
36216747 2022
18
Neurodevelopmental Implications on Urological Self-Management Among People Living with Spina Bifida: A Practical Guide for Urology Providers. 62
36473589 2022
19
The Association of Health Literacy with Health-Related Quality of Life in Youth and Young Adults with Spina Bifida: A Cross-Sectional Study. 62
35970239 2022
20
Late diagnosis of dorsolumbar lipomyelomeningocele with tethered cord in a middle aged adult: A case report from Nepal. 62
36189164 2022
21
Prenatal intracranial hypotension syndrome: new insights into the mechanisms of fenestration of septi pellucidi and ventriculomegaly in fetuses with open spinal dysraphism. 62
34074204 2022
22
A rare incidental finding of an isolated S1 butterfly vertebra: A case report. 62
36212764 2022
23
Sonographic spectrum and postnatal outcomes of early-onset versus late-onset fetal cerebral ventriculomegaly. 62
33292033 2022
24
[Analysis of anorectal manometry data in central and peripheral neurological deseases: Review of the literature]. 62
36030152 2022
25
Potentially Preventable Hospitalizations Among Adults With Pediatric-Onset Disabilities. 62
36336517 2022
26
Developing clinical algorithm for identifying acute lumbar spondylolysis in elementary school children - Classification and regression tree analysis. 62
35343399 2022
27
Association of ethnicity and adaptive functioning with health-related quality of life in pediatric myelomeningocele. 62
36442218 2022
28
The art of introducing clean intermittent catheterization: How families respond and adapt: A qualitative study. 62
36352775 2022
29
[Repair Surgery of Myelomeningocele]. 62
36426520 2022
30
The incidence of congenital lumbosacral malformations in young male Turkish military school candidates population. 62
34391615 2022
31
Wnt/planar cell polarity signaling controls morphogenetic movements of gastrulation and neural tube closure. 62
36369349 2022
32
Postnatal Surgical Correction of Myelomeningoceles: Pre- and Intraoperative Risk Factors Associated with Postoperative Neurological Outcomes. 62
36410703 2022
33
Long-term Reoperation Rates After Open Versus Minimally Invasive Spine Surgery for Degenerative Lumbar Disease: Five Year Follow-Up of 2,130 Patients. 62
36442783 2022
34
Long-term results of artificial urinary sphincter implantation for urinary incontinence due to intrinsic sphincter deficiency in children. 62
36434815 2022
35
Tethered cord release in patients after open fetal myelomeningocele closure: intraoperative neuromonitoring data and patient outcomes. 62
36380051 2022
36
Electrodiagnosis has a potential to identify neural damage in asymptomatic infants with closed spinal dysraphism. 62
36445470 2022
37
Association between ambulatory skills and diffusion tensor imaging of corpus callosal white matter in infants with spina bifida. 62
35638229 2022
38
Nurse-led eHealth transition care program for adolescents with spina bifida: A feasibility and acceptability study. 62
35939952 2022
39
Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida. 62
36401747 2022
40
The role of neurosurgeons in global public health: the case of folic acid fortification of staple foods to prevent spina bifida. 62
36334286 2022
41
Follow-up of brace-treated scoliosis in children with cerebral palsy and spina bifida. 62
36442215 2022
42
Exploratory study of the provision of academic and health-related accommodations to transition-age adolescents and emerging adults with spina bifida. 62
36442216 2022
43
Primary vs patch-based skin closure for in-utero spina bifida repair. 62
35751885 2022
44
Working memory and cognitive flexibility predict growth trajectories of sluggish cognitive tempo in youth with spina bifida. 62
35196965 2022
45
Impact of AREDF-UA during and after fetal spina bifida repair on postoperative, neonatal and 2-year neurodevelopmental outcome. 62
36357943 2022
46
Information needs of parents of children with congenital anomalies across Europe: a EUROlinkCAT survey. 62
36368959 2022
47
Conservative treatment of non-healing plantar skin ulcer complicated by infection and fistula in congenital clubfoot. A case report. 62
36448360 2022
48
Cannabidiol impairs neural tube closure in mouse whole embryo culture. 62
35416425 2022
49
Prenatal diagnosis and pregnancy outcome of major structural anomalies detectable in the first trimester: A population-based cohort study in the Netherlands. 62
35821640 2022
50
Education and employment as young adults living with spina bifida transition to adulthood in the USA: A study of the National Spina Bifida Patient Registry. 62
36385606 2022

Variations for Meningocele

Expression for Meningocele

Search GEO for disease gene expression data for Meningocele.

Pathways for Meningocele

Pathways related to Meningocele according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.18 VANGL1 SHH NOTCH3 AFP
2
Show member pathways
10.26 MESP2 HES7

GO Terms for Meningocele

Biological processes related to Meningocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of proteolysis GO:0030162 9.56 SHH C2CD3
2 central nervous system development GO:0007417 9.56 SHH MNX1 GRHL3 CELSR1
3 planar cell polarity pathway involved in neural tube closure GO:0090179 9.33 GRHL3 CELSR1
4 pattern specification process GO:0007389 9.02 SHH GRHL3 C2CD3

Sources for Meningocele

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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