MCID: MNN007
MIFTS: 37

Meningocele

Categories: Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Meningocele

MalaCards integrated aliases for Meningocele:

Name: Meningocele 12 74 52 29 54 43 15 71
Congenital Meningocele 71
Spinal Meningocele 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1088
MeSH 43 D008588
SNOMED-CT 67 32941003
UMLS 71 C0009730 C0025299 C1261470

Summaries for Meningocele

MalaCards based summary : Meningocele, also known as congenital meningocele, is related to sacrococcygeal teratoma and neural tube defects. An important gene associated with Meningocele is NOTCH3 (Notch Receptor 3), and among its related pathways/superpathways is Gene regulatory network modelling somitogenesis. Affiliated tissues include spinal cord, brain and bone, and related phenotypes are cellular and embryo

Wikipedia : 74 Spina bifida is a birth defect in which there is incomplete closing of the spine and membranes around... more...

Related Diseases for Meningocele

Diseases in the Meningocele family:

Posterior Meningocele

Diseases related to Meningocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 291)
# Related Disease Score Top Affiliating Genes
1 sacrococcygeal teratoma 32.9 MNX1 AFP
2 neural tube defects 31.5 VANGL1 RPL34 NF1 MNX1 MESP2 ALX3
3 benign teratoma 30.8 MNX1 AFP
4 intracranial hypotension 30.5 RPL34 CRLF1
5 arachnoiditis 30.0 RPL34 CRLF1
6 tethered spinal cord syndrome 29.9 VANGL1 RPL34 MNX1 AFP
7 obstructive hydrocephalus 29.9 NF1 CRLF1 AFP
8 scoliosis 29.6 VANGL1 NF1 MESP2 HES7
9 hajdu-cheney syndrome 29.6 MESP2 HES7
10 spondylocostal dysostosis, autosomal recessive 29.5 MESP2 HES7
11 spondylocostal dysostosis 1, autosomal recessive 29.5 MESP2 HES7
12 adams-oliver syndrome 29.0 XXYLT1 NOTCH3 MESP2 HES7
13 lateral meningocele syndrome 12.9
14 sacral defect with anterior meningocele 12.7
15 cranial meningocele 12.3
16 posterior meningocele 12.3
17 sacral meningocele conotruncal heart defects 12.3
18 myelomeningocele 11.7
19 currarino syndrome 11.7
20 superficial siderosis 11.5
21 curry-jones syndrome 11.2
22 neurofibromatosis, type iv, of riccardi 10.8
23 hydrocephalus 10.5
24 meningitis 10.5
25 constipation 10.4
26 encephalocele 10.4
27 marfan syndrome 10.4
28 meningoencephalocele 10.4
29 urachal adenocarcinoma 10.4 NF1 AFP
30 epididymal neoplasm 10.4 NF1 AFP
31 neurilemmoma of the fifth cranial nerve 10.3 NF1 CRLF1
32 neurofibromatosis, type i 10.3
33 central nervous system hemangioma 10.3 RPL34 NF1
34 trigeminal nerve neoplasm 10.3 NF1 CRLF1
35 corpus callosum lipoma 10.3 NF1 ALX3
36 mollaret meningitis 10.3
37 cerebral hemisphere lipoma 10.3 NF1 ALX3
38 chromosome 2p16.1-p15 deletion syndrome 10.3 USP34 SNORA70B
39 hematocele of tunica vaginalis testis 10.3 CRLF1 AFP
40 dandy-walker syndrome 10.3
41 back pain 10.3
42 cleft palate, isolated 10.3
43 cystic teratoma 10.3
44 meningioma, radiation-induced 10.3
45 meningioma, familial 10.3
46 spinal meningioma 10.3
47 teratoma 10.3
48 secretory meningioma 10.3
49 lymphoplasmacyte-rich meningioma 10.3
50 ovarian cyst 10.3

Graphical network of the top 20 diseases related to Meningocele:



Diseases related to Meningocele

Symptoms & Phenotypes for Meningocele

MGI Mouse Phenotypes related to Meningocele:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 ALX3 C2CD3 MESP2 MNX1 NF1 NOTCH3
2 embryo MP:0005380 9.86 ALX3 C2CD3 HES7 MESP2 NF1 NOTCH3
3 mortality/aging MP:0010768 9.73 AFP ALX3 C2CD3 CRLF1 HES7 MESP2
4 limbs/digits/tail MP:0005371 9.7 ALX3 C2CD3 HES7 MESP2 NF1 TMEM67
5 skeleton MP:0005390 9.32 ALX3 HES7 MESP2 MNX1 NF1 NOTCH3

Drugs & Therapeutics for Meningocele

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long Term Assessment and Outcome of Adult Patients With Congenital Genitourinary Abnormalities. Recruiting NCT03061084
2 Study of Fetoscopic Repair of Myelomeningocele in Fetuses With Isolated Spina Bifida Recruiting NCT03090633

Search NIH Clinical Center for Meningocele

Cochrane evidence based reviews: meningocele

Genetic Tests for Meningocele

Genetic tests related to Meningocele:

# Genetic test Affiliating Genes
1 Meningocele 29

Anatomical Context for Meningocele

MalaCards organs/tissues related to Meningocele:

40
Spinal Cord, Brain, Bone, Heart, Skin, Kidney, Thyroid

Publications for Meningocele

Articles related to Meningocele:

(show top 50) (show all 1534)
# Title Authors PMID Year
1
Prenatal diagnosis of sacrococcygeal teratoma with constitutional partial monosomy 7q/trisomy 2p. 54 61
14663834 2003
2
Prenatal diagnosis of closed spina bifida: multicenter case series and review of the literature. 61
30001658 2020
3
Retained medullary cord with sacral subcutaneous meningocele and congenital dermal sinus. 61
31297584 2020
4
Congenital meningocele associated with corpus callosum agenesis and midline superior labial cleft due to Tessier 0-14 facial fissure: A case report. 61
31706112 2020
5
Spontaneous closure of myelomeningocele. 61
32025870 2020
6
Recurrent Pneumococcal Meningitis Secondary to Nasoethmoidal Meningocele. 61
31876613 2020
7
Approaching the Sella through the Nonpneumatized Sphenoid in Pediatric Patients. 61
32021750 2020
8
Filum Terminale Ependymoma in an Infant with Meningocele. 61
31962322 2020
9
An antibody to Notch3 reverses the skeletal phenotype of lateral meningocele syndrome in male mice. 61
31188489 2020
10
Surgical outcomes of six bulldogs with spinal lumbosacral meningomyelocele or meningocele. 61
31758707 2020
11
Dynamic mapping of the corticospinal tract in open cordotomy and myelomeningocele surgery. 61
31973921 2020
12
[Repair of Spontaneous Cerebrospinal Fluid Leakage due to Multiple Defects in the Skull Base:A Case Report]. 61
31983689 2020
13
Dural Tears in Percutaneous Biportal Endoscopic Spine Surgery: Anatomical Location and Management. 61
31958589 2020
14
Anatomo-radiological study supporting the use of ipsilateral nasoseptal flap for the transpterygoid management of temporo-sphenoidal meningoceles. A review of 21 cases. 61
31631054 2020
15
One-Stage Anteroposterior Extensive Atlantoaxial Osteotomy Correction With 16 Months Follow-up: Technical Case Report. 61
31828342 2019
16
Occipital teratoma in a neonate with CHARGE syndrome: a case report. 61
31797071 2019
17
Neurosurgical Management of Lateral Meningocele Syndrome: A Clinical Update for the Pediatric Neurosurgeon. 61
31838470 2019
18
Syringomyelia in children with closed spinal dysraphism: long-term outcomes after surgical intervention. 61
31835253 2019
19
Rare Association of Dandy-Walker Malformation With a Giant Occipital Meningocele. 61
32035712 2019
20
Meningocele Manqué Discovered During Filum Terminale Resection in Occult Tethered Cord Syndrome. 61
31430540 2019
21
Unilateral vagus nerve lesion revealing clival meningocele. 61
31221588 2019
22
Neuropathic Pain due to Neurofibromatosis Treated With Transcutaneous Electrical Nerve Stimulation in a Pregnant Patient: A Case Report. 61
31361663 2019
23
Predictors of surgical treatment in children with tethered fibrofatty filum terminale. 61
31675690 2019
24
Giant Symptomatic Meningocele as a Delayed, Adult Complication of Lipomyelomeningocele. 61
31760189 2019
25
[What's New in Papilloedema, Pseudotumor Cerebri and Idiopathic Intracranial Hypertension]. 61
31600818 2019
26
The reconstruction of skull base defects in infants using pedicled nasoseptal flap-a review of four cases. 61
30968177 2019
27
Anterior Sacral Meningocele: A New Classification and Treatment using the Dorsal Transsacral Approach. 61
31651686 2019
28
Surgical Repair of an Occipital Meningocele in a Foal. 61
31668304 2019
29
A New Technique Using Modified Dehaan's Method for Median Cleft Lip Closure: A Case Report. 61
31448395 2019
30
Thoracic Meningocele and Cervical Syringomyelia Treated with Ventriculoperitoneal Shunt. 61
31152885 2019
31
Successful Management of a Giant Anterior Sacral Meningocele Associated with Low-Dysplastic Spondylolisthesis from a Single Posterior Approach: Case Report. 61
31009790 2019
32
Treatment of a sacral fracture associated with an intrasacral meningocele: A case report. 61
31315523 2019
33
Dural ectasia in Marfan syndrome and other hereditary connective tissue disorders: a 10-year follow-up study. 61
30998996 2019
34
Prevalence of Spontaneous Asymptomatic Facial Nerve Canal Meningoceles: A Retrospective Review. 61
31296524 2019
35
Terminal syringomyelia associated with lumbar limited dorsal myeloschisis. 61
31317225 2019
36
Severe bacterial meningitis due to an enterothecal fistula in a 6-year-old child with Currarino syndrome: evaluation of surgical strategy with review of the literature. 61
30968178 2019
37
"Cable Suturing Technique" a Dural Obliteration Method for the Prevention of Cerebellar Herniation through a Large Occipital Meningocele. 61
31497162 2019
38
Optic Nerve Sheath Meningocele With Optic Disc Pit: A Rare Finding. 61
30664128 2019
39
Prevalence of temporal bone tegmen defects among patients with Marfan syndrome. 61
30861355 2019
40
Dural Ectasia of the Optic Nerve: A Rare Presentation in Neurofibromatosis Type I. 61
31001034 2019
41
Chiari malformations in adults: A single center surgical experience with special emphasis on the kinetics of clinical improvement. 61
30744958 2019
42
Neural Tube Defects: A Retrospective Study of 69 Cases. 61
31143270 2019
43
Short-term results of patients with neural tube defects followed-up in the Konya region, Turkey. 61
30708397 2019
44
Reconstructions With Different and New Techniques of Large and Extensive Myelomeningocele Defects. 61
30394972 2019
45
Assessment of Dural Ectasia Using Computed Tomodensitometry as a Criterion in Marfan Syndrome. 61
30371622 2019
46
Repair of a Transclival Meningocele Through a Transoral Approach: Case Report and Literature Review. 61
30579031 2019
47
An Unusual Presentation as Recurrent Abortions in a Case of Giant Presacral Epidermoid Cyst Mimicking an Anterior Sacral Meningocele. 61
31108068 2019
48
Fallopian Canal Meningocele with Spontaneous Cerebrospinal Fluid Otorrhea: Case Report and Systematic Review of the Literature. 61
30321684 2019
49
Untreated meningomyelocele and squamous cell carcinoma: a case report and literature review. 61
30652927 2019
50
Slender Stalk with Combined Features of Saccular Limited Dorsal Myeloschisis and Congenital Dermal Sinus in a Neonate. 61
30654374 2019

Variations for Meningocele

Expression for Meningocele

Search GEO for disease gene expression data for Meningocele.

Pathways for Meningocele

Pathways related to Meningocele according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.66 MESP2 HES7

GO Terms for Meningocele

Biological processes related to Meningocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 artery morphogenesis GO:0048844 8.96 NOTCH3 NF1
2 Notch signaling pathway GO:0007219 8.8 NOTCH3 MESP2 HES7

Sources for Meningocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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