MCID: MNN007
MIFTS: 38

Meningocele

Categories: Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Meningocele

MalaCards integrated aliases for Meningocele:

Name: Meningocele 12 77 54 30 56 45 15 74
Congenital Meningocele 74
Spinal Meningocele 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1088
MeSH 45 D008588
SNOMED-CT 69 32941003

Summaries for Meningocele

MalaCards based summary : Meningocele, also known as congenital meningocele, is related to lateral meningocele syndrome and sacral defect with anterior meningocele. An important gene associated with Meningocele is NOTCH3 (Notch Receptor 3). Affiliated tissues include spinal cord, brain and bone, and related phenotypes are respiratory system and skeleton

Wikipedia : 77 Spina bifida is a birth defect where there is incomplete closing of the backbone and membranes around... more...

Related Diseases for Meningocele

Diseases in the Meningocele family:

Posterior Meningocele

Diseases related to Meningocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 lateral meningocele syndrome 12.7
2 sacral defect with anterior meningocele 12.6
3 cranial meningocele 12.2
4 posterior meningocele 12.2
5 sacral meningocele conotruncal heart defects 12.2
6 neural tube defects 11.6
7 currarino syndrome 11.5
8 myelomeningocele 11.5
9 sacrococcygeal teratoma 11.4
10 curry-jones syndrome 11.1
11 neurofibromatosis, type i 10.4
12 neurofibromatosis, type iv, of riccardi 10.4
13 meningitis 10.4
14 marfan syndrome 10.3
15 meningoencephalocele 10.2
16 ovarian cyst 10.2
17 cleft palate, isolated 10.2
18 dandy-walker syndrome 10.2
19 dermoid cyst 10.2
20 hydrocephalus 10.1
21 teratoma 10.1
22 arachnoid cysts 10.1
23 dandy-walker complex 10.1
24 encephalocele 10.1
25 diastematomyelia 10.0
26 syringomyelia 10.0
27 intracranial hypertension 10.0
28 bacterial meningitis 10.0
29 neurofibroma 10.0
30 tethered cord syndrome 10.0
31 epidermoid cysts 9.9
32 anencephaly 9.9
33 anus, imperforate 9.9
34 siderosis 9.9
35 klippel-feil syndrome 9.9
36 cauda equina syndrome 9.9
37 squamous cell carcinoma 9.9
38 constipation 9.9
39 intracranial hypotension 9.9
40 amniotic band syndrome 9.9
41 chiari malformation 9.9
42 superficial siderosis of the central nervous system 9.9
43 syncope 9.9
44 superficial siderosis 9.9
45 lipomatosis, multiple 9.8 ALX3 MNX1
46 hajdu-cheney syndrome 9.8
47 breast cancer 9.8
48 coloboma of macula 9.8
49 frontonasal dysplasia 1 9.8
50 pilonidal sinus 9.8

Graphical network of the top 20 diseases related to Meningocele:



Diseases related to Meningocele

Symptoms & Phenotypes for Meningocele

MGI Mouse Phenotypes related to Meningocele:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.55 ALX3 MNX1 NF1 NOTCH3 VANGL1
2 skeleton MP:0005390 9.35 ALX3 MNX1 NF1 NOTCH3 VANGL1
3 vision/eye MP:0005391 8.92 ALX3 HSF4 NF1 NOTCH3

Drugs & Therapeutics for Meningocele

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective Cohort of Transitional Urology Patients Recruiting NCT03061084
2 Primary Tumor Research and Outcome Network Recruiting NCT02790983

Search NIH Clinical Center for Meningocele

Cochrane evidence based reviews: meningocele

Genetic Tests for Meningocele

Genetic tests related to Meningocele:

# Genetic test Affiliating Genes
1 Meningocele 30

Anatomical Context for Meningocele

MalaCards organs/tissues related to Meningocele:

42
Spinal Cord, Brain, Bone, Skin, Eye, Colon, Heart

Publications for Meningocele

Articles related to Meningocele:

(show top 50) (show all 619)
# Title Authors Year
1
Rectothecal fistula complicating anterior sacral meningocele repair. ( 30386449 )
2019
2
Optic Nerve Sheath Meningocele With Optic Disc Pit: A Rare Finding. ( 30664128 )
2019
3
Closure of a giant anterior sacral meningocele with an omental flap in a patient with Marfan syndrome: case report. ( 29799321 )
2018
4
Temporal Bone Meningocele Associated With Superior Canal Dehiscence. ( 29889793 )
2018
5
Rare Case of Cerebrospinal Fluid Proctorrhea Caused by Anterior Sacral Meningocele with Rectothecal Fistula. ( 29572171 )
2018
6
Clival meningocele causing bilateral hearing loss in a child due to superficial siderosis of the central nervous system: case report. ( 29451456 )
2018
7
Retained medullary cord extending to a sacral subcutaneous meningocele. ( 29101613 )
2018
8
Rare Case of Tricompartmental Arachnoid Cyst Spanning Infratentorial, Supratentorial, and Extracranial Compartment and Presenting as Posterior Parietal Meningocele. ( 29698795 )
2018
9
Surgical management for a huge presacral teratoma and a meningocele in an adult with Currarino triad: a case report. ( 29352751 )
2018
10
Fungating Growth of Squamous Cell Carcinoma in Long-Standing Meningocele. ( 29393254 )
2018
11
Analysis of petrous apex meningocele associated with meningioma: is there any relation with chronic intracranial hypertension? ( 29188303 )
2018
12
Enlargement of sacral subcutaneous meningocele associated with retained medullary cord. ( 29704125 )
2018
13
Fetal meningocele manquAc. ( 29766970 )
2018
14
Association of syringomyelia with lower urinary tract dysfunction in anterior sacral meningocele with a tethered spinal cord: A case report and literature summary. ( 29682854 )
2018
15
The lateral meningocele syndrome mutation causes marked osteopenia in mice. ( 30042232 )
2018
16
Rupture of Giant Anterior Sacral Meningocele in a Patient with Marfan Syndrome: Diagnosis and Management. ( 30092475 )
2018
17
Late onset meningocele in a case of meningocele manqué. ( 30218141 )
2018
18
Optic nerve sheath meningocele. ( 30237744 )
2018
19
Optic nerve sheath meningocele associated with coloboma. ( 30270035 )
2018
20
Fallopian Canal Meningocele with Spontaneous Cerebrospinal Fluid Otorrhea: Case Report and Systematic Review of the Literature. ( 30321684 )
2018
21
Repair of a transclival meningocele through a transoral approach: Case report and literature review. ( 30579031 )
2018
22
Rudimentary Meningocele of the Scalp: A Pitfall in the Diagnosis of Vascular Neoplasms. ( 30687556 )
2018
23
Meningocele and Meningoencephalocele of the Lateral Wall of Sphenoidal Sinus. ( 29059790 )
2017
24
Recurrent Abortion and Tethered Cord Syndrome Caused by Anterior Sacral Meningocele: A Report of a Rare Case with a Review of the Literature. ( 28279771 )
2017
25
A case of cranium bifidum with meningocele in Ayrshire calf. ( 28086878 )
2017
26
Unusual Presentation of Intrasacral Meningocele: A Case Report and Overview. ( 28553381 )
2017
27
Stabilization of Visual Function After Optic Nerve Sheath Fenestration for Optic Nerve Meningocele. ( 28538611 )
2017
28
Thalidomide Embryopathy as Possible Cause of Anterior Sacral Meningocele: A Case Report. ( 28990356 )
2017
29
Encephalocele development from a congenital meningocele: case report. ( 28885087 )
2017
30
Multidisciplinary surgical treatment of presacral meningocele and teratoma in an adult with Currarino triad. ( 28584680 )
2017
31
Meningocele manquAc. ( 28478392 )
2017
32
Imaging Findings of Jugular Foramen Meningocele in a Neurofibromatosis Type 1 Patient. ( 29435380 )
2017
33
Meningocele manquAc: a comprehensive review of this enigmatic finding in occult spinal dysraphism. ( 28620735 )
2017
34
Clinical Features, Imaging Characteristics, and Long-term Outcome of Dogs with Cranial Meningocele or Meningoencephalocele. ( 28247440 )
2017
35
Intrathoracic meningocele associated with neurofibromatosis Type 1 and a novel technique for surgical repair: case report. ( 28621617 )
2017
36
Anterior sacral meningocele infected with Fusobacterium in a patient with recently diagnosed colorectal carcinoma - a case report. ( 29216848 )
2017
37
Pulsatile Proptosis due to Intraorbital Meningocele. ( 28674516 )
2017
38
Optic Nerve Sheath Meningocele Simulating an Optic Nerve Pit. ( 28746249 )
2017
39
Anterior sacral meningocele presenting as intracystic bleeding. ( 28523383 )
2017
40
Giant lumbar meningocele in type-1 neurofibromatosis. ( 29904266 )
2017
41
Transvaginal ultrasound-guided aspiration of an anterior sacral meningocele masquerading as a hydrosalpinx, resulting in abscess formation. ( 30363340 )
2017
42
Posttraumatic Temporal Bone Meningocele Presenting as a Cystic Mass in the External Auditory Canal. ( 27389328 )
2016
43
Occult intrasacral meningocele leading to inadvertent dural tap during caudal block detected by point of care ultrasonography. ( 27747981 )
2016
44
A Case of Cutaneous Meningioma in the Rudimentary Meningocele. ( 27348900 )
2016
45
A rare case of giant occipital meningocele with Dandy Walker Syndrome: Can it grow bigger than this? ( 28217162 )
2016
46
Endoscopic Management of Congenital Intranasal Meningocele in 3-Month Old Infant. ( 27833887 )
2016
47
Anterior sacral meningocele presenting as right adnexal cyst. ( 26854740 )
2016
48
Dandy Walker syndrome with giant occipital meningocele with craniovertebral anomalies: Challenges faced during anaesthesia. ( 26962265 )
2016
49
Nasoethmoidal meningocele in a child presenting bilateral congenital cystic adenomatoid malformation: Evidence for a new entity or consequence of gestational exposures? ( 26932830 )
2016
50
Meningocele and Meningoencephalocele of the Lateral Wall of Sphenoidal Sinus: The Role of the Endoscopic Endonasal Surgery. ( 26585733 )
2016

Variations for Meningocele

Expression for Meningocele

Search GEO for disease gene expression data for Meningocele.

Pathways for Meningocele

GO Terms for Meningocele

Biological processes related to Meningocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.56 ALX3 HSF4 MNX1 NOTCH3
2 cellular response to heat GO:0034605 9.16 HSF4 NF1
3 pigmentation GO:0043473 8.96 NF1 VANGL1
4 artery morphogenesis GO:0048844 8.62 NF1 NOTCH3

Molecular functions related to Meningocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 8.8 ALX3 HSF4 MNX1

Sources for Meningocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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