MCID: MNN007
MIFTS: 41

Meningocele

Categories: Rare diseases, Neuronal diseases, Fetal diseases

Aliases & Classifications for Meningocele

MalaCards integrated aliases for Meningocele:

Name: Meningocele 12 76 53 29 55 44 15 73
Congenital Meningocele 73
Spinal Meningocele 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1088
MeSH 44 D008588

Summaries for Meningocele

MalaCards based summary : Meningocele, also known as congenital meningocele, is related to anus, imperforate and lateral meningocele syndrome. An important gene associated with Meningocele is NOTCH3 (Notch 3). Affiliated tissues include spinal cord, bone and skin, and related phenotypes are cellular and growth/size/body region

Wikipedia : 76 Spina bifida is a birth defect where there is incomplete closing of the backbone and membranes around... more...

Related Diseases for Meningocele

Diseases in the Meningocele family:

Posterior Meningocele

Diseases related to Meningocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Related Disease Score Top Affiliating Genes
1 anus, imperforate 29.1 MNX1 SATB2
2 lateral meningocele syndrome 12.5
3 sacral defect with anterior meningocele 12.4
4 cranial meningocele 12.0
5 posterior meningocele 12.0
6 sacral meningocele conotruncal heart defects 12.0
7 neural tube defects 11.5
8 currarino syndrome 11.4
9 myelomeningocele 11.4
10 sacrococcygeal teratoma 11.2
11 curry-jones syndrome 10.9
12 cervicitis 10.2
13 meningitis 10.2
14 neurofibromatosis, type i 10.2
15 neurofibromatosis, type iv, of riccardi 10.2
16 telecanthus 10.2 ADAMTS18 NOTCH3
17 marfan syndrome 10.0
18 encephalocele 10.0
19 meningoencephalocele 10.0
20 ovarian cyst 10.0
21 cleft palate, isolated 10.0
22 dandy-walker syndrome 10.0
23 dermoid cyst 10.0
24 teratoma 9.9
25 arachnoiditis 9.9
26 cerebritis 9.9
27 neurofibroma 9.9
28 arachnoid cysts 9.9
29 dandy-walker complex 9.9
30 poland syndrome 9.9 ALX3 NF1
31 spinal meningioma 9.8 HSF4 NF1
32 diastematomyelia 9.8
33 hydrocephalus 9.8
34 syringomyelia 9.8
35 bacterial meningitis 9.8
36 tethered cord syndrome 9.8
37 spinal canal and spinal cord meningioma 9.8 HSF4 NF1
38 epidermoid cysts 9.7
39 spinal intradural arachnoid cysts 9.7
40 neural tube defects, folate-sensitive 9.7
41 siderosis 9.7
42 klippel-feil syndrome 9.7
43 choroiditis 9.7
44 cauda equina syndrome 9.7
45 squamous cell carcinoma 9.7
46 constipation 9.7
47 pharyngitis 9.7
48 intracranial hypotension 9.7
49 mediastinitis 9.7
50 intracranial hypertension 9.7

Graphical network of the top 20 diseases related to Meningocele:



Diseases related to Meningocele

Symptoms & Phenotypes for Meningocele

MGI Mouse Phenotypes related to Meningocele:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.95 ALX3 MNX1 NF1 NOTCH3 SATB2 VANGL1
2 growth/size/body region MP:0005378 9.91 NF1 NOTCH3 SATB2 VANGL1 ADAMTS18 ALX3
3 endocrine/exocrine gland MP:0005379 9.88 ADAMTS18 ALX3 MNX1 NF1 NOTCH3 SATB2
4 digestive/alimentary MP:0005381 9.85 ADAMTS18 ALX3 MNX1 NF1 SATB2
5 embryo MP:0005380 9.83 ALX3 NF1 NOTCH3 SATB2 VANGL1
6 nervous system MP:0003631 9.73 ALX3 MNX1 NF1 NOTCH3 SATB2 VANGL1
7 respiratory system MP:0005388 9.7 ADAMTS18 ALX3 MNX1 NF1 NOTCH3 SATB2
8 limbs/digits/tail MP:0005371 9.62 ALX3 NF1 SATB2 VANGL1
9 skeleton MP:0005390 9.43 ALX3 MNX1 NF1 NOTCH3 SATB2 VANGL1
10 vision/eye MP:0005391 9.02 ADAMTS18 ALX3 HSF4 NF1 NOTCH3

Drugs & Therapeutics for Meningocele

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective Cohort of Transitional Urology Patients Recruiting NCT03061084
2 Primary Tumor Research and Outcome Network Recruiting NCT02790983

Search NIH Clinical Center for Meningocele

Cochrane evidence based reviews: meningocele

Genetic Tests for Meningocele

Genetic tests related to Meningocele:

# Genetic test Affiliating Genes
1 Meningocele 29

Anatomical Context for Meningocele

MalaCards organs/tissues related to Meningocele:

41
Spinal Cord, Bone, Skin, Eye, Uterus, Heart

Publications for Meningocele

Articles related to Meningocele:

(show top 50) (show all 588)
# Title Authors Year
1
Closure of a giant anterior sacral meningocele with an omental flap in a patient with Marfan syndrome: case report. ( 29799321 )
2018
2
Temporal Bone Meningocele Associated With Superior Canal Dehiscence. ( 29889793 )
2018
3
Rare Case of Cerebrospinal Fluid Proctorrhea Caused by Anterior Sacral Meningocele with Rectothecal Fistula. ( 29572171 )
2018
4
Clival meningocele causing bilateral hearing loss in a child due to superficial siderosis of the central nervous system: case report. ( 29451456 )
2018
5
Retained medullary cord extending to a sacral subcutaneous meningocele. ( 29101613 )
2018
6
Rare Case of Tricompartmental Arachnoid Cyst Spanning Infratentorial, Supratentorial, and Extracranial Compartment and Presenting as Posterior Parietal Meningocele. ( 29698795 )
2018
7
Surgical management for a huge presacral teratoma and a meningocele in an adult with Currarino triad: a case report. ( 29352751 )
2018
8
Fungating Growth of Squamous Cell Carcinoma in Long-Standing Meningocele. ( 29393254 )
2018
9
Analysis of petrous apex meningocele associated with meningioma: is there any relation with chronic intracranial hypertension? ( 29188303 )
2018
10
Enlargement of sacral subcutaneous meningocele associated with retained medullary cord. ( 29704125 )
2018
11
Fetal meningocele manquAc. ( 29766970 )
2018
12
Association of syringomyelia with lower urinary tract dysfunction in anterior sacral meningocele with a tethered spinal cord: A case report and literature summary. ( 29682854 )
2018
13
Meningocele and Meningoencephalocele of the Lateral Wall of Sphenoidal Sinus. ( 29059790 )
2017
14
Recurrent Abortion and Tethered Cord Syndrome Caused by Anterior Sacral Meningocele: A Report of a Rare Case with a Review of the Literature. ( 28279771 )
2017
15
A case of cranium bifidum with meningocele in Ayrshire calf. ( 28086878 )
2017
16
Unusual Presentation of Intrasacral Meningocele: A Case Report and Overview. ( 28553381 )
2017
17
Stabilization of Visual Function After Optic Nerve Sheath Fenestration for Optic Nerve Meningocele. ( 28538611 )
2017
18
Thalidomide Embryopathy as Possible Cause of Anterior Sacral Meningocele: A Case Report. ( 28990356 )
2017
19
Encephalocele development from a congenital meningocele: case report. ( 28885087 )
2017
20
Multidisciplinary surgical treatment of presacral meningocele and teratoma in an adult with Currarino triad. ( 28584680 )
2017
21
Meningocele manquAc. ( 28478392 )
2017
22
Imaging Findings of Jugular Foramen Meningocele in a Neurofibromatosis Type 1 Patient. ( 29435380 )
2017
23
Meningocele manquAc: a comprehensive review of this enigmatic finding in occult spinal dysraphism. ( 28620735 )
2017
24
Clinical Features, Imaging Characteristics, and Long-term Outcome of Dogs with Cranial Meningocele or Meningoencephalocele. ( 28247440 )
2017
25
Intrathoracic meningocele associated with neurofibromatosis Type 1 and a novel technique for surgical repair: case report. ( 28621617 )
2017
26
Anterior sacral meningocele infected with Fusobacterium in a patient with recently diagnosed colorectal carcinoma - a case report. ( 29216848 )
2017
27
Pulsatile Proptosis due to Intraorbital Meningocele. ( 28674516 )
2017
28
Optic Nerve Sheath Meningocele Simulating an Optic Nerve Pit. ( 28746249 )
2017
29
Anterior sacral meningocele presenting as intracystic bleeding. ( 28523383 )
2017
30
Posttraumatic Temporal Bone Meningocele Presenting as a Cystic Mass in the External Auditory Canal. ( 27389328 )
2016
31
Occult intrasacral meningocele leading to inadvertent dural tap during caudal block detected by point of care ultrasonography. ( 27747981 )
2016
32
A Case of Cutaneous Meningioma in the Rudimentary Meningocele. ( 27348900 )
2016
33
A rare case of giant occipital meningocele with Dandy Walker Syndrome: Can it grow bigger than this? ( 28217162 )
2016
34
Endoscopic Management of Congenital Intranasal Meningocele in 3-Month Old Infant. ( 27833887 )
2016
35
Anterior sacral meningocele presenting as right adnexal cyst. ( 26854740 )
2016
36
Dandy Walker syndrome with giant occipital meningocele with craniovertebral anomalies: Challenges faced during anaesthesia. ( 26962265 )
2016
37
Nasoethmoidal meningocele in a child presenting bilateral congenital cystic adenomatoid malformation: Evidence for a new entity or consequence of gestational exposures? ( 26932830 )
2016
38
Meningocele and Meningoencephalocele of the Lateral Wall of Sphenoidal Sinus: The Role of the Endoscopic Endonasal Surgery. ( 26585733 )
2016
39
Giant Intrathoracic Meningocele and Breast Cancer in a Neurofibromatosis Type I Patient. ( 27847582 )
2016
40
Differential diagnosis of anterior sacral meningocele during the evaluation of post-hysterectomy pelvic collections. ( 27403027 )
2016
41
Squamous cell carcinoma arising from neglected meningocele. ( 28194302 )
2016
42
Neck swelling due to skull base (pseudo)meningocele protruding through a congenital skull base bone defect: a case report. ( 27830332 )
2016
43
OPTIC NERVE MENINGOCELE SIMULATING EXTRAOCULAR EXTENSION OF CHOROIDAL MELANOMA. ( 27617394 )
2016
44
An autopsy case of superficial siderosis of the central nervous system accompanied by anterior sacral polycystic meningocele in neurofibromatosis type 1. ( 27356733 )
2016
45
Meningocele and Meningoencephalocele of the Lateral Wall of the Sphenoid Sinus. ( 26732955 )
2016
46
Successful management of a giant anterior sacral meningocele with an endoscopic cutting stapler: case report. ( 26745349 )
2016
47
Type I Cutaneous Meningioma (Rudimentary Meningocele) With Intradural Attachment to the Phylum Terminale. ( 27828803 )
2016
48
Currarino Syndrome and the Effect of a Large Anterior Sacral Meningocele on Distal Colostogram in an Anorectal Malformation. ( 27761181 )
2016
49
Thoracic meningocele in lumbo-costo-vertebral syndrome in a child: possible enlargement with repeated motion by anchoring to the diaphragm. ( 27058456 )
2016
50
Lateral meningocele (Lehman) syndrome: A child with a novel NOTCH3 mutation. ( 26754023 )
2016

Variations for Meningocele

Expression for Meningocele

Search GEO for disease gene expression data for Meningocele.

Pathways for Meningocele

GO Terms for Meningocele

Biological processes related to Meningocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.83 ALX3 HSF4 MNX1 NOTCH3 SATB2
2 transcription, DNA-templated GO:0006351 9.8 ALX3 HSF4 MNX1 NOTCH3 SATB2
3 multicellular organism development GO:0007275 9.67 ALX3 NOTCH3 SATB2 VANGL1
4 cellular response to heat GO:0034605 9.32 HSF4 NF1
5 embryonic skeletal system morphogenesis GO:0048704 9.26 ALX3 SATB2
6 pigmentation GO:0043473 9.16 NF1 VANGL1
7 eye development GO:0001654 8.96 ADAMTS18 HSF4
8 artery morphogenesis GO:0048844 8.62 NF1 NOTCH3

Molecular functions related to Meningocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 8.92 ALX3 HSF4 MNX1 SATB2

Sources for Meningocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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