MCID: MNN007
MIFTS: 39

Meningocele

Categories: Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Meningocele

MalaCards integrated aliases for Meningocele:

Name: Meningocele 12 76 53 29 55 44 15 73
Congenital Meningocele 73
Spinal Meningocele 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1088
MeSH 44 D008588
SNOMED-CT 68 32941003

Summaries for Meningocele

MalaCards based summary : Meningocele, also known as congenital meningocele, is related to anus, imperforate and lateral meningocele syndrome. An important gene associated with Meningocele is NOTCH3 (Notch 3). Affiliated tissues include spinal cord, bone and skin, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Wikipedia : 76 Spina bifida is a birth defect where there is incomplete closing of the backbone and membranes around... more...

Related Diseases for Meningocele

Diseases in the Meningocele family:

Posterior Meningocele

Diseases related to Meningocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 anus, imperforate 29.8 SATB2 MNX1
2 lateral meningocele syndrome 12.7
3 sacral defect with anterior meningocele 12.5
4 cranial meningocele 12.2
5 posterior meningocele 12.2
6 sacral meningocele conotruncal heart defects 12.1
7 neural tube defects 11.6
8 currarino syndrome 11.5
9 myelomeningocele 11.5
10 sacrococcygeal teratoma 11.4
11 curry-jones syndrome 11.0
12 neurofibromatosis, type i 10.4
13 meningitis 10.4
14 marfan syndrome 10.3
15 meningoencephalocele 10.2
16 ovarian cyst 10.2
17 cleft palate, isolated 10.1
18 dandy-walker syndrome 10.1
19 dermoid cyst 10.1
20 hydrocephalus 10.1
21 teratoma 10.1
22 arachnoid cysts 10.0
23 dandy-walker complex 10.0
24 encephalocele 10.0
25 telecanthus 10.0 NOTCH3 ADAMTS18
26 diastematomyelia 10.0
27 syringomyelia 10.0
28 bacterial meningitis 10.0
29 neurofibroma 10.0
30 tethered cord syndrome 10.0
31 cloacal exstrophy 9.9 SATB2 MNX1
32 epidermoid cysts 9.9
33 anencephaly 9.9
34 siderosis 9.9
35 klippel-feil syndrome 9.9
36 cauda equina syndrome 9.9
37 squamous cell carcinoma 9.9
38 constipation 9.9
39 intracranial hypotension 9.9
40 intracranial hypertension 9.9
41 amniotic band syndrome 9.9
42 chiari malformation 9.9
43 superficial siderosis of the central nervous system 9.9
44 syncope 9.9
45 superficial siderosis 9.9
46 spinal canal and spinal cord meningioma 9.8 NF1 HSF4
47 physical disorder 9.8 SATB2 MNX1
48 hydrolethalus syndrome 1 9.8 SATB2 ADAMTS18
49 spinal meningioma 9.8 NF1 HSF4
50 hajdu-cheney syndrome 9.7

Graphical network of the top 20 diseases related to Meningocele:



Diseases related to Meningocele

Symptoms & Phenotypes for Meningocele

MGI Mouse Phenotypes related to Meningocele:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.77 MNX1 NF1 NOTCH3 SATB2 VANGL1
2 endocrine/exocrine gland MP:0005379 9.65 ADAMTS18 MNX1 NF1 NOTCH3 SATB2
3 growth/size/body region MP:0005378 9.63 ADAMTS18 MNX1 NF1 NOTCH3 SATB2 VANGL1
4 digestive/alimentary MP:0005381 9.62 ADAMTS18 MNX1 NF1 SATB2
5 respiratory system MP:0005388 9.43 ADAMTS18 MNX1 NF1 NOTCH3 SATB2 VANGL1
6 skeleton MP:0005390 9.02 MNX1 NF1 NOTCH3 SATB2 VANGL1

Drugs & Therapeutics for Meningocele

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective Cohort of Transitional Urology Patients Recruiting NCT03061084
2 Primary Tumor Research and Outcome Network Recruiting NCT02790983

Search NIH Clinical Center for Meningocele

Cochrane evidence based reviews: meningocele

Genetic Tests for Meningocele

Genetic tests related to Meningocele:

# Genetic test Affiliating Genes
1 Meningocele 29

Anatomical Context for Meningocele

MalaCards organs/tissues related to Meningocele:

41
Spinal Cord, Bone, Skin, Eye, Colon, Heart, Thyroid

Publications for Meningocele

Articles related to Meningocele:

(show top 50) (show all 616)
# Title Authors Year
1
Rectothecal fistula complicating anterior sacral meningocele repair. ( 30386449 )
2019
2
Closure of a giant anterior sacral meningocele with an omental flap in a patient with Marfan syndrome: case report. ( 29799321 )
2018
3
Temporal Bone Meningocele Associated With Superior Canal Dehiscence. ( 29889793 )
2018
4
Rare Case of Cerebrospinal Fluid Proctorrhea Caused by Anterior Sacral Meningocele with Rectothecal Fistula. ( 29572171 )
2018
5
Clival meningocele causing bilateral hearing loss in a child due to superficial siderosis of the central nervous system: case report. ( 29451456 )
2018
6
Retained medullary cord extending to a sacral subcutaneous meningocele. ( 29101613 )
2018
7
Rare Case of Tricompartmental Arachnoid Cyst Spanning Infratentorial, Supratentorial, and Extracranial Compartment and Presenting as Posterior Parietal Meningocele. ( 29698795 )
2018
8
Surgical management for a huge presacral teratoma and a meningocele in an adult with Currarino triad: a case report. ( 29352751 )
2018
9
Fungating Growth of Squamous Cell Carcinoma in Long-Standing Meningocele. ( 29393254 )
2018
10
Analysis of petrous apex meningocele associated with meningioma: is there any relation with chronic intracranial hypertension? ( 29188303 )
2018
11
Enlargement of sacral subcutaneous meningocele associated with retained medullary cord. ( 29704125 )
2018
12
Fetal meningocele manquAc. ( 29766970 )
2018
13
The lateral meningocele syndrome mutation causes marked osteopenia in mice. ( 30042232 )
2018
14
Rupture of Giant Anterior Sacral Meningocele in a Patient with Marfan Syndrome: Diagnosis and Management. ( 30092475 )
2018
15
Anterior sacral meningocele presenting as intracystic bleeding. ( 28523383 )
2018
16
Optic Nerve Sheath Meningocele Simulating an Optic Nerve Pit. ( 28746249 )
2018
17
Association of syringomyelia with lower urinary tract dysfunction in anterior sacral meningocele with a tethered spinal cord: A case report and literature summary. ( 29682854 )
2018
18
Late onset meningocele in a case of meningocele manqué. ( 30218141 )
2018
19
Optic nerve sheath meningocele. ( 30237744 )
2018
20
Optic nerve sheath meningocele associated with coloboma. ( 30270035 )
2018
21
Fallopian Canal Meningocele with Spontaneous Cerebrospinal Fluid Otorrhea: Case Report and Systematic Review of the Literature. ( 30321684 )
2018
22
Meningocele and Meningoencephalocele of the Lateral Wall of Sphenoidal Sinus. ( 29059790 )
2017
23
Recurrent Abortion and Tethered Cord Syndrome Caused by Anterior Sacral Meningocele: A Report of a Rare Case with a Review of the Literature. ( 28279771 )
2017
24
A case of cranium bifidum with meningocele in Ayrshire calf. ( 28086878 )
2017
25
Unusual Presentation of Intrasacral Meningocele: A Case Report and Overview. ( 28553381 )
2017
26
Stabilization of Visual Function After Optic Nerve Sheath Fenestration for Optic Nerve Meningocele. ( 28538611 )
2017
27
Thalidomide Embryopathy as Possible Cause of Anterior Sacral Meningocele: A Case Report. ( 28990356 )
2017
28
Encephalocele development from a congenital meningocele: case report. ( 28885087 )
2017
29
Multidisciplinary surgical treatment of presacral meningocele and teratoma in an adult with Currarino triad. ( 28584680 )
2017
30
Meningocele manquAc. ( 28478392 )
2017
31
Imaging Findings of Jugular Foramen Meningocele in a Neurofibromatosis Type 1 Patient. ( 29435380 )
2017
32
Meningocele manquAc: a comprehensive review of this enigmatic finding in occult spinal dysraphism. ( 28620735 )
2017
33
Clinical Features, Imaging Characteristics, and Long-term Outcome of Dogs with Cranial Meningocele or Meningoencephalocele. ( 28247440 )
2017
34
Intrathoracic meningocele associated with neurofibromatosis Type 1 and a novel technique for surgical repair: case report. ( 28621617 )
2017
35
Anterior sacral meningocele infected with Fusobacterium in a patient with recently diagnosed colorectal carcinoma - a case report. ( 29216848 )
2017
36
Pulsatile Proptosis due to Intraorbital Meningocele. ( 28674516 )
2017
37
Giant lumbar meningocele in type-1 neurofibromatosis. ( 29904266 )
2017
38
Transvaginal ultrasound-guided aspiration of an anterior sacral meningocele masquerading as a hydrosalpinx, resulting in abscess formation. ( 30363340 )
2017
39
Posttraumatic Temporal Bone Meningocele Presenting as a Cystic Mass in the External Auditory Canal. ( 27389328 )
2016
40
Occult intrasacral meningocele leading to inadvertent dural tap during caudal block detected by point of care ultrasonography. ( 27747981 )
2016
41
A Case of Cutaneous Meningioma in the Rudimentary Meningocele. ( 27348900 )
2016
42
A rare case of giant occipital meningocele with Dandy Walker Syndrome: Can it grow bigger than this? ( 28217162 )
2016
43
Endoscopic Management of Congenital Intranasal Meningocele in 3-Month Old Infant. ( 27833887 )
2016
44
Anterior sacral meningocele presenting as right adnexal cyst. ( 26854740 )
2016
45
Dandy Walker syndrome with giant occipital meningocele with craniovertebral anomalies: Challenges faced during anaesthesia. ( 26962265 )
2016
46
Nasoethmoidal meningocele in a child presenting bilateral congenital cystic adenomatoid malformation: Evidence for a new entity or consequence of gestational exposures? ( 26932830 )
2016
47
Meningocele and Meningoencephalocele of the Lateral Wall of Sphenoidal Sinus: The Role of the Endoscopic Endonasal Surgery. ( 26585733 )
2016
48
Giant Intrathoracic Meningocele and Breast Cancer in a Neurofibromatosis Type I Patient. ( 27847582 )
2016
49
Differential diagnosis of anterior sacral meningocele during the evaluation of post-hysterectomy pelvic collections. ( 27403027 )
2016
50
Squamous cell carcinoma arising from neglected meningocele. ( 28194302 )
2016

Variations for Meningocele

Expression for Meningocele

Search GEO for disease gene expression data for Meningocele.

Pathways for Meningocele

GO Terms for Meningocele

Biological processes related to Meningocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to heat GO:0034605 9.26 HSF4 NF1
2 pigmentation GO:0043473 9.16 NF1 VANGL1
3 eye development GO:0001654 8.96 ADAMTS18 HSF4
4 artery morphogenesis GO:0048844 8.62 NF1 NOTCH3

Sources for Meningocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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