MCID: MNN007
MIFTS: 39

Meningocele

Categories: Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Meningocele

MalaCards integrated aliases for Meningocele:

Name: Meningocele 12 74 52 29 54 15 71
Congenital Meningocele 71
Spinal Meningocele 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1088
SNOMED-CT 67 171131006
UMLS 71 C0009730 C0025299 C1261470

Summaries for Meningocele

Disease Ontology : 12 A spina bifida that is characterized by herniation of the meninges between the vertebrae.

MalaCards based summary : Meningocele, also known as congenital meningocele, is related to lateral meningocele syndrome and sacral defect with anterior meningocele. An important gene associated with Meningocele is NOTCH3 (Notch Receptor 3), and among its related pathways/superpathways is Gene regulatory network modelling somitogenesis. Affiliated tissues include spinal cord, brain and bone, and related phenotypes are cellular and embryo

Wikipedia : 74 Spina bifida is a birth defect in which there is incomplete closing of the spine and the membranes... more...

Related Diseases for Meningocele

Diseases in the Meningocele family:

Posterior Meningocele

Diseases related to Meningocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 300)
# Related Disease Score Top Affiliating Genes
1 lateral meningocele syndrome 34.7 NOTCH3 MESP2 HES7
2 sacral defect with anterior meningocele 34.3 VANGL1 FUZ
3 sacrococcygeal teratoma 32.9 MNX1 AFP
4 currarino syndrome 32.5 VANGL1 MNX1
5 neural tube defects 30.3 VANGL1 RPL34 NF1 MNX1 MESP2 FUZ
6 hajdu-cheney syndrome 30.2 NOTCH3 MESP2 HES7
7 spondylocostal dysostosis, autosomal recessive 30.0 MESP2 HES7
8 spondylocostal dysostosis 1, autosomal recessive 30.0 MESP2 HES7
9 intracranial hypotension 29.9 RPL34 CRLF1
10 tethered spinal cord syndrome 29.9 VANGL1 RPL34 MNX1 AFP
11 anencephaly 29.8 VANGL1 CELSR1 AFP
12 adams-oliver syndrome 29.8 NOTCH3 MESP2 HES7
13 obstructive hydrocephalus 29.6 NF1 CRLF1 AFP
14 arachnoiditis 29.4 RPL34 CRLF1
15 coloboma of macula 28.6 TMEM67 C2CD3 ALX3
16 cranial meningocele 12.3
17 posterior meningocele 12.3
18 sacral meningocele conotruncal heart defects 12.3
19 myelomeningocele 11.7
20 superficial siderosis 11.5
21 curry-jones syndrome 11.2
22 neurofibromatosis 10.8
23 hydrocephalus 10.6
24 meningitis 10.6
25 constipation 10.4
26 encephalocele 10.4
27 marfan syndrome 10.4
28 meningoencephalocele 10.4
29 urachal adenocarcinoma 10.4 NF1 AFP
30 epididymal neoplasm 10.3 NF1 AFP
31 neurofibromatosis, type i 10.3
32 scoliosis 10.3
33 mollaret meningitis 10.3
34 dandy-walker syndrome 10.3
35 back pain 10.3
36 cleft palate, isolated 10.3
37 cystic teratoma 10.3
38 meningioma, radiation-induced 10.3
39 meningioma, familial 10.3
40 benign teratoma 10.3
41 spinal meningioma 10.3
42 teratoma 10.3
43 secretory meningioma 10.3
44 lymphoplasmacyte-rich meningioma 10.3
45 ovarian cyst 10.3
46 mature teratoma 10.3
47 bacterial meningitis 10.3
48 cerebrospinal fluid leak 10.3
49 total spina bifida aperta 10.2 VANGL1 FUZ
50 cervicothoracic spina bifida aperta 10.2 VANGL1 FUZ

Graphical network of the top 20 diseases related to Meningocele:



Diseases related to Meningocele

Symptoms & Phenotypes for Meningocele

MGI Mouse Phenotypes related to Meningocele:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.14 ALX3 C2CD3 CELSR1 FUZ MESP2 MNX1
2 embryo MP:0005380 10.07 ALX3 C2CD3 CELSR1 FUZ HES7 MESP2
3 mortality/aging MP:0010768 10.07 AFP ALX3 C2CD3 CELSR1 CRLF1 FUZ
4 limbs/digits/tail MP:0005371 9.97 ALX3 C2CD3 CELSR1 FUZ HES7 MESP2
5 nervous system MP:0003631 9.9 ALX3 C2CD3 CELSR1 CRLF1 FUZ MESP2
6 respiratory system MP:0005388 9.5 ALX3 CELSR1 FUZ MNX1 NF1 NOTCH3
7 skeleton MP:0005390 9.36 ALX3 CELSR1 FUZ HES7 MESP2 MNX1

Drugs & Therapeutics for Meningocele

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long Term Assessment and Outcome of Adult Patients With Congenital Genitourinary Abnormalities. Recruiting NCT03061084
2 Study of Fetoscopic Repair of Myelomeningocele in Fetuses With Isolated Spina Bifida Recruiting NCT03090633

Search NIH Clinical Center for Meningocele

Genetic Tests for Meningocele

Genetic tests related to Meningocele:

# Genetic test Affiliating Genes
1 Meningocele 29

Anatomical Context for Meningocele

MalaCards organs/tissues related to Meningocele:

40
Spinal Cord, Brain, Bone, Skin, Eye, Heart, Colon

Publications for Meningocele

Articles related to Meningocele:

(show top 50) (show all 1550)
# Title Authors PMID Year
1
Prenatal diagnosis of sacrococcygeal teratoma with constitutional partial monosomy 7q/trisomy 2p. 54 61
14663834 2003
2
Advancement in Neuromodulation Technology with the Innovation of Design-Specific Peripheral Nerve Stimulators: Sural Nerve Stimulation for Radiculopathy. 61
32249315 2020
3
A recurrent PJA1 variant in trigonocephaly and neurodevelopmental disorders. 61
32530565 2020
4
Giant Cephalocele Case Mimicking Cystic Neoplasia in Skull Base. 61
32371684 2020
5
Enlargement of Extraspinal Cysts in Spinal Dysraphism : A Reason for Early Untethering. 61
32336061 2020
6
Neonatal ten-year retrospective study on neural tube defects in a second level University Hospital. 61
32448340 2020
7
Expansion of the phenotype of lateral meningocele syndrome. 61
32141180 2020
8
Surgical Management of Symptomatic Boxing-Induced Spinal Cerebrospinal Fluid Leak After Failed Epidural Blood Patch. 61
32376374 2020
9
Anterior Sacral Meningocele: A New Classification and Treatment Using the Dorsal Transsacral Approach. 61
31651686 2020
10
Spontaneous closure of myelomeningocele. 61
32025870 2020
11
Dynamic mapping of the corticospinal tract in open cordotomy and myelomeningocele surgery. 61
31973921 2020
12
Terminal syringomyelia associated with lumbar limited dorsal myeloschisis. 61
31317225 2020
13
Bilateral Temporal Bone Meningocele Presenting With Otogenic Meningitis. 61
32347113 2020
14
Dural Tears in Percutaneous Biportal Endoscopic Spine Surgery: Anatomical Location and Management. 61
31958589 2020
15
Meningocele tourniquet syndrome. 61
32172393 2020
16
Prenatal diagnosis of closed spina bifida: multicenter case series and review of the literature. 61
30001658 2020
17
Occipital teratoma in a neonate with CHARGE syndrome: a case report. 61
31797071 2020
18
Currarino syndrome presenting as a cerebrospinal fluid leak from the dermal sinus tract: case report. 61
32114544 2020
19
Retained medullary cord with sacral subcutaneous meningocele and congenital dermal sinus. 61
31297584 2020
20
Giant Symptomatic Meningocele as a Delayed, Adult Complication of Lipomyelomeningocele. 61
31760189 2020
21
Congenital meningocele associated with corpus callosum agenesis and midline superior labial cleft due to Tessier 0-14 facial fissure: A case report. 61
31706112 2020
22
Recurrent Pneumococcal Meningitis Secondary to Nasoethmoidal Meningocele. 61
31876613 2020
23
Approaching the Sella through the Nonpneumatized Sphenoid in Pediatric Patients. 61
32021750 2020
24
Postoperative cardiorespiratory arrest in a case of cervical meningocele. 61
32257571 2020
25
Filum Terminale Ependymoma in an Infant with Meningocele. 61
31962322 2020
26
Orbital meningocele in two case studies. 61
32494394 2020
27
Spontaneous Cerebral Spinal Fluid Rhinorrhea with Meningocele Secondary to Congenital Foramen Rotundum Defect: A Case Report and Review of Literature. 61
32181200 2020
28
Surgical outcomes of six bulldogs with spinal lumbosacral meningomyelocele or meningocele. 61
31758707 2020
29
Neurosurgical Management of Lateral Meningocele Syndrome: A Clinical Update for the Pediatric Neurosurgeon. 61
31838470 2020
30
An antibody to Notch3 reverses the skeletal phenotype of lateral meningocele syndrome in male mice. 61
31188489 2020
31
Notch Pathway and Inherited Diseases: Challenge and Promise. 61
32060876 2020
32
[Repair of Spontaneous Cerebrospinal Fluid Leakage due to Multiple Defects in the Skull Base:A Case Report]. 61
31983689 2020
33
Successful Treatment of Spontaneous Cerebrospinal Fluid Rhinorrhea With Endoscopic Third Ventriculostomy and Lumboperitoneal Shunt: A Case Report. 61
32082119 2020
34
Anatomo-radiological study supporting the use of ipsilateral nasoseptal flap for the transpterygoid management of temporo-sphenoidal meningoceles. A review of 21 cases. 61
31631054 2020
35
Anterior sacral meningocele complicated by rectothecal fistula and rectorrhea: A Case report and review of the literature. 61
32494392 2020
36
Syringomyelia in children with closed spinal dysraphism: long-term outcomes after surgical intervention. 61
31835253 2019
37
One-Stage Anteroposterior Extensive Atlantoaxial Osteotomy Correction With 16 Months Follow-up: Technical Case Report. 61
31828342 2019
38
Rare Association of Dandy-Walker Malformation With a Giant Occipital Meningocele. 61
32035712 2019
39
Meningocele Manqué Discovered During Filum Terminale Resection in Occult Tethered Cord Syndrome. 61
31430540 2019
40
Unilateral vagus nerve lesion revealing clival meningocele. 61
31221588 2019
41
[What's New in Papilloedema, Pseudotumor Cerebri and Idiopathic Intracranial Hypertension]. 61
31600818 2019
42
Predictors of surgical treatment in children with tethered fibrofatty filum terminale. 61
31675690 2019
43
Neuropathic Pain due to Neurofibromatosis Treated With Transcutaneous Electrical Nerve Stimulation in a Pregnant Patient: A Case Report. 61
31361663 2019
44
The reconstruction of skull base defects in infants using pedicled nasoseptal flap-a review of four cases. 61
30968177 2019
45
Surgical Repair of an Occipital Meningocele in a Foal. 61
31668304 2019
46
Thoracic Meningocele and Cervical Syringomyelia Treated with Ventriculoperitoneal Shunt. 61
31152885 2019
47
Successful Management of a Giant Anterior Sacral Meningocele Associated with Low-Dysplastic Spondylolisthesis from a Single Posterior Approach: Case Report. 61
31009790 2019
48
A New Technique Using Modified Dehaan's Method for Median Cleft Lip Closure: A Case Report. 61
31448395 2019
49
Treatment of a sacral fracture associated with an intrasacral meningocele: A case report. 61
31315523 2019
50
Dural ectasia in Marfan syndrome and other hereditary connective tissue disorders: a 10-year follow-up study. 61
30998996 2019

Variations for Meningocele

Expression for Meningocele

Search GEO for disease gene expression data for Meningocele.

Pathways for Meningocele

Pathways related to Meningocele according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.66 MESP2 HES7

GO Terms for Meningocele

Biological processes related to Meningocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Notch signaling pathway GO:0007219 9.33 NOTCH3 MESP2 HES7
2 artery morphogenesis GO:0048844 9.32 NOTCH3 NF1
3 regulation of smoothened signaling pathway GO:0008589 9.26 FUZ C2CD3
4 multicellular organism development GO:0007275 9.17 VANGL1 NOTCH3 MESP2 HES7 FUZ CELSR1
5 establishment of planar polarity GO:0001736 8.96 FUZ CELSR1

Sources for Meningocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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