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Meningococcemia

Categories: Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Meningococcemia

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MalaCards integrated aliases for Meningococcemia:

Name: Meningococcemia 53 55 73

Classifications:

MalaCards categories:
Global: Rare diseases
See all MalaCards categories (disease lists)


External Ids:

UMLS 73 C0025306
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Summaries for Meningococcemia

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MalaCards based summary : Meningococcemia is related to meningococcal meningitis and meningitis. An important gene associated with Meningococcemia is BPI (Bactericidal Permeability Increasing Protein), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Vaccines and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and cardiovascular system

Wikipedia : 76 Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed... more...

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Related Diseases for Meningococcemia

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Diseases related to Meningococcemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 meningococcal meningitis 32.9 CFP MBL2
2 meningitis 31.0 CFP IL1B MBL2
3 neisseria meningitidis infection 30.2 CFP IL1RN MBL2
4 purpura fulminans 30.1 PROC PROCR SERPINC1
5 complement deficiency 29.8 CFP MBL2
6 shwartzman phenomenon 29.6 SERPINE1 THBD
7 purpura 29.3 PROC PROCR SERPINC1 THBD
8 disseminated intravascular coagulation 28.9 F5 SERPINC1 SERPINE1 THBD
9 protein c deficiency 28.3 F5 PROC SERPINC1 THBD
10 myocardial infarction 25.5 CCL5 F5 IL1B PROCR SERPINC1 SERPINE1
11 dengue disease 10.9
12 chronic follicular conjunctivitis 10.8 IL1A IL1B
13 mannose-binding lectin deficiency 10.7 CFP MBL2
14 prosthetic joint infection 10.7 IL1B MBL2
15 irritant dermatitis 10.7 IL1A IL1B
16 neonatal stroke 10.7 PROC SERPINE1
17 bacteremia 2 10.7 BPI MBL2
18 limbal stem cell deficiency 10.6 IL1A IL1B
19 gastric cancer, hereditary diffuse 10.6 IL1B IL1RN
20 schnitzler syndrome 10.5 IL1B IL1RN
21 cerebral artery occlusion 10.5 IL1B IL1RN
22 scabies 10.5 CFP IL1A MBL2
23 osteosclerotic myeloma 10.5 IL1B IL1RN
24 acanthamoeba keratitis 10.5 F5 MBL2
25 inferior vena cava interruption 10.4 F5 SERPINE1
26 amaurosis fugax 10.4 F5 SERPINE1
27 bacterial vaginosis 10.4 IL1A IL1B MBL2
28 livedoid vasculopathy 10.4 F5 SERPINE1
29 blood protein disease 10.3 PROC SERPINC1
30 3mc syndrome 10.3 CFP MBL2
31 aseptic meningitis 10.3 IL1A IL1B IL1RN
32 root resorption 10.3 IL1A IL1B IL1RN
33 fibrinolytic defect 10.3 SERPINC1 SERPINE1
34 somatoform disorder 10.3 IL1A IL1B IL1RN
35 cryptogenic cirrhosis 10.3 F5 SERPINE1
36 aggressive periodontitis 10.3 IL1A IL1B IL1RN
37 silicosis 10.3 IL1A IL1B IL1RN
38 burns 10.3 IL1B SERPINC1
39 osteomyelitis 10.3 IL1A IL1B IL1RN
40 bone inflammation disease 10.3 IL1A IL1B IL1RN
41 streptococcal meningitis 10.3 CFP MBL2
42 hydrarthrosis 10.3 IL1B IL1RN
43 vulvar vestibulitis syndrome 10.3 IL1B IL1RN MBL2
44 argentine hemorrhagic fever 10.3 SERPINC1 SERPINE1
45 extrapulmonary tuberculosis 10.3 IL1B IL1RN MBL2
46 periodontal disease 10.2 IL1A IL1B IL1RN
47 factor xiii deficiency 10.2 F5 SERPINE1
48 blue toe syndrome 10.2 SERPINC1 SERPINE1
49 subendocardial myocardial infarction 10.2 SERPINC1 SERPINE1
50 angina pectoris 10.2 SERPINC1 SERPINE1

Graphical network of the top 20 diseases related to Meningococcemia:



Diseases related to Meningococcemia
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Symptoms & Phenotypes for Meningococcemia

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GenomeRNAi Phenotypes related to Meningococcemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.02 MBL2 PROC SERPINC1 SERPINE1 THBD

MGI Mouse Phenotypes related to Meningococcemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 PROCR SERPINC1 CFP F5 SERPINE1 IL1A
2 hematopoietic system MP:0005397 9.85 PROCR CCL5 SERPINC1 SERPINE1 IL1A THBD
3 homeostasis/metabolism MP:0005376 9.7 PROCR CFP SERPINC1 F5 SERPINE1 IL1A
4 immune system MP:0005387 9.36 CCL5 SERPINC1 CFP SERPINE1 IL1A THBD
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Drugs & Therapeutics for Meningococcemia

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Drugs for Meningococcemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 3,Phase 2
2
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
3
Butyric Acid Experimental, Investigational Phase 2 107-92-6 264
4 Cortisol succinate Phase 2
5 Hydrocortisone 17-butyrate 21-propionate Phase 2
6 Hydrocortisone acetate Phase 2
7 Hydrocortisone-17-butyrate Phase 2
8 Antibodies Phase 2
9 Immunoglobulins Phase 2
10 Anti-Inflammatory Agents Phase 2
11
Salmon Calcitonin Approved, Investigational 47931-85-1 16129616
12
Calcitonin gene-related peptide Investigational 83652-28-2
13 calcitonin
14 Bone Density Conservation Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Menactra® in US Adolescents When Administered Concomitantly With Tdap Vaccine Completed NCT00777257 Phase 4
2 Immunology and Safety of Menactra® in Children in Saudi Arabia Completed NCT00539032 Phase 3
3 Study of a Booster Dose of Meningococcal Diphtheria Toxoid Conjugate Vaccine in Adolescents Completed NCT00777790 Phase 2
4 Study of Antibody Responses After a Dose of Tetravalent Meningococcal Diphtheria Conjugate Vaccine in Children Completed NCT00771849 Phase 2
5 Antibody Persistence and Booster Dose Response in Subjects Who Received Menactra® Three Years Earlier in Study MTA26 Completed NCT00700713 Phase 2
6 Study of Reduced Dose of Menomune® in Children Who Previously Received Meningococcal Diphtheria Toxoid Conjugate Vaccine Completed NCT00772070 Phase 2
7 Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis - a Randomised Pilot Study Completed NCT00732277 Phase 2 hydrocortisone
8 Antibody Responses Following Meningococcal Tetravalent (A, C, Y, and W-135) Conjugate Vaccination in Healthy Adults Terminated NCT00772629 Phase 2
9 Correlation Between Cytokines and the Severity of Meningococcal Disease Completed NCT01133834
10 Petechiae In Children (PIC) Study: Defining A Clinical Decision Rule for The Management Of Fever and Non-Blanching Rashes In Children Including The Role Of Point Of Care Testing For Procalcitonin & Neisseria Meningitidis DNA. Recruiting NCT03378258

Search NIH Clinical Center for Meningococcemia

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Genetic Tests for Meningococcemia

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Anatomical Context for Meningococcemia

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MalaCards organs/tissues related to Meningococcemia:

41
Bone, Testes, Skin, Atrioventricular Node, Endothelial, Heart, Colon
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Publications for Meningococcemia

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Articles related to Meningococcemia:

(show top 50) (show all 302)
# Title Authors Year
1
Meningococcal meningitis with neurological complications and meningococcemia due to serogroup W sequence type 11 complex. ( 29373268 )
2018
2
Reply letter to "Fatal meningococcemia due to Neisseria meningitidis serogroup Y in a vaccinated child receiving eculizumab". ( 29923779 )
2018
3
Fatal meningococcemia due to Neisseria meningitidis serogroup Y in a vaccinated child receiving eculizumab. ( 29883245 )
2018
4
Meningococcemia in vaccinated patient under treatment with eculizumab. ( 26994815 )
2017
5
A Case of Fulminant Meningococcemia: It Is All in the Complement. ( 28808592 )
2017
6
No Neck Pain: Meningococcemia. ( 28821376 )
2017
7
Fulminant meningococcemia. ( 28271045 )
2017
8
Purpura Fulminans in Acute Meningococcemia. ( 28236134 )
2017
9
Fatal meningococcemia mimicking intra-abdominal emergency. ( 29260273 )
2017
10
Chronic meningococcemia in an immunocompetent child. ( 27535891 )
2016
11
Meningococcemia in Adults: A Review of the Literature. ( 26984070 )
2016
12
Late Sequel of Meningococcemia: Skeletal Dysplasia. ( 26960252 )
2016
13
A rare case of chronic meningococcemia. ( 27728401 )
2016
14
Experimental Evidence of Bacterial Colonization of Human Coronary Microvasculature and Myocardial Tissue during Meningococcemia. ( 27481255 )
2016
15
Right lower quadrant abdominal pain, fever, and hypotension: an atypical presentation of meningococcemia. ( 25825033 )
2015
16
Meningococcal meningitis with meningococcemia: a rare sporadic case in an elderly patient with no history of contact with infected individuals. ( 25420647 )
2015
17
Chronic meningococcemia presenting as a recurrent painful rash without fever in a teenage girl. ( 25970111 )
2015
18
Meningococcemia Presenting as a Myocardial Infarction. ( 26640720 )
2015
19
Corticosteroid-induced meningococcal meningitis in a patient with chronic meningococcemia. ( 24577072 )
2014
20
MBL2 Deficiency is Associated with Higher Genomic Bacterial Loads during Meningococcemia in Young Children. ( 24977653 )
2014
21
Rapid recovery following fulminant meningococcemia complicated by myocarditis in a 15-year-old Nepalese girl: a case report. ( 23950664 )
2013
22
Meningococcemia: the pediatric orthopedic sequelae. ( 23622829 )
2013
23
Purpura fulminans caused by meningococcemia in an infant. ( 23921694 )
2013
24
Meningococcemia and heparin-induced thrombocytopenia: a dangerous combination. ( 23061921 )
2013
25
Meningococcemia due to the 2000 Hajj-associated outbreak strain (Serogroup W-135 ST-11) with immunoreactive complications. ( 24047748 )
2013
26
Pathogenesis of meningococcemia. ( 23732856 )
2013
27
Rash in meningococcemia. ( 22892518 )
2012
28
Using the internet to trace contacts of a fatal meningococcemia case-New York City, 2010. ( 22635194 )
2012
29
A baby with meningococcemia and septic shock. ( 22689868 )
2012
30
Purpura fulminans from meningococcemia mimicking Stevens-Johnson syndrome in an adult patient taking etanercept. ( 23247497 )
2012
31
Chronic meningococcemia cutaneous lesions involve meningococcal perivascular invasion through the remodeling of endothelial barriers. ( 22412064 )
2012
32
Meningococcemia presenting as acute painful mononeuritis multiplex. ( 22100105 )
2012
33
Atypical presentation of fatal meningococcemia: peritonitis and paradoxical centrifugal purpura fulminans of late onset. ( 21075588 )
2011
34
Association of chronic meningococcemia with infection by meningococci with underacylated lipopolysaccharide. ( 21459106 )
2011
35
Fatal meningococcemia. ( 23882342 )
2011
36
Orthopaedic sequelae of childhood meningococcemia: management considerations and outcome. ( 20844162 )
2010
37
Clinical images: Purpura fulminans caused by meningococcemia. ( 19858241 )
2010
38
Severe rhabdomyolysis associated in meningococcemia. ( 20927300 )
2010
39
Dermacase. Question: Can you identify this condition? Diagnosis: Meningococcemia. ( 20841592 )
2010
40
Chronic meningococcemia in a 16-year-old boy: a case report. ( 19829911 )
2009
41
Giant condyloma with demise secondary to meningococcemia in an infant boy. ( 19596116 )
2009
42
Application of the vacuum-assisted closure in pediatric patients with orthopedic sequelae of meningococcemia: report of a case successfully treated. ( 19620896 )
2009
43
Fever, abdominal pain, and leukopenia in a 13-year-old: a case-based review of meningococcemia. ( 18657927 )
2009
44
The Case. Generalized petechiae and acute renal failure: bilateral renal cortical necrosis in meningococcemia. ( 18516063 )
2008
45
Purpuric rash of meningococcemia. ( 18438796 )
2008
46
Value of a novel Neisseria meningitidis--specific polymerase chain reaction assay in skin biopsy specimens as a diagnostic tool in chronic meningococcemia. ( 18559767 )
2008
47
Meningococcemia without meningitis in Japan. ( 18758132 )
2008
48
Meningococcemia. ( 19384501 )
2008
49
Orchitis as a rare complication of meningococcemia in a young infant. ( 17387516 )
2007
50
Cardiac rescue with intra-aortic balloon counterpulsation in refractory shock due to acute meningococcemia. ( 17276846 )
2007
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Variations for Meningococcemia

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Expression for Meningococcemia

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Search GEO for disease gene expression data for Meningococcemia.
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Pathways for Meningococcemia

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Pathways related to Meningococcemia according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 66
Show member pathways
 13.01 F5 PROC PROCR SERPINC1 SERPINE1 THBD
2
Collagen chain trimerization 66
Show member pathways
 12.58 F5 PROC SERPINC1 THBD
3
Influenza A 37
Show member pathways
 12.51 CCL5 CFP IL1A IL1B
4
Cell surface interactions at the vascular wall 66
Show member pathways
 11.97 PROC PROCR THBD
5
IL-1 Family Signaling Pathways 65
Show member pathways
 11.91 IL1A IL1B IL1RN SERPINE1
6
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.9 IL1A IL1B IL1RN
7
Fluid shear stress and atherosclerosis 37
11.81 IL1A IL1B THBD
8
Senescence and Autophagy in Cancer 1
11.68 IL1A IL1B SERPINE1
9
Formation of Fibrin Clot (Clotting Cascade) 66
Show member pathways
 11.63 F5 PROC PROCR SERPINC1 SERPINE1 THBD
10
Rheumatoid arthritis 37
11.56 CCL5 IL1A IL1B
11
AGE-RAGE signaling pathway in diabetic complications 37
11.55 IL1A IL1B SERPINE1 THBD
12
Complement and coagulation cascades 1 37
11.31 F5 MBL2 PROC PROCR SERPINC1 SERPINE1
13
Interleukin-10 signaling 66
11.15 CCL5 IL1A IL1B IL1RN
14
Prion diseases 37
11.04 CCL5 IL1A IL1B
15
Cytokines and Inflammatory Response 1
11.02 IL1A IL1B
16
Interleukin-1 processing 66
10.25 IL1A IL1B
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GO Terms for Meningococcemia

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Cellular components related to Meningococcemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 BPI CCL5 CFP F5 IL1A IL1B
2 endoplasmic reticulum lumen GO:0005788 9.46 CFP F5 PROC SERPINC1
3 extracellular space GO:0005615 9.4 BPI CCL5 CFP F5 IL1A IL1B

Biological processes related to Meningococcemia according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.86 CCL5 IL1A IL1B IL1RN
2 cytokine-mediated signaling pathway GO:0019221 9.81 CCL5 IL1A IL1B IL1RN
3 immune response GO:0006955 9.8 BPI CCL5 CFP IL1A IL1B IL1RN
4 regulation of signaling receptor activity GO:0010469 9.77 CCL5 IL1A IL1B IL1RN SERPINE1
5 positive regulation of angiogenesis GO:0045766 9.74 IL1A IL1B SERPINE1
6 leukocyte migration GO:0050900 9.71 IL1B PROC PROCR THBD
7 interleukin-1-mediated signaling pathway GO:0070498 9.67 IL1A IL1B IL1RN
8 positive regulation of interleukin-8 production GO:0032757 9.59 IL1B SERPINE1
9 positive regulation of vascular endothelial growth factor production GO:0010575 9.58 IL1A IL1B
10 positive regulation of mitotic nuclear division GO:0045840 9.58 IL1A IL1B
11 positive regulation of monocyte chemotaxis GO:0090026 9.55 CCL5 SERPINE1
12 blood coagulation GO:0007596 9.55 F5 PROC PROCR SERPINC1 THBD
13 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.54 IL1A IL1B
14 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.52 IL1A IL1B
15 negative regulation of fibrinolysis GO:0051918 9.48 SERPINE1 THBD
16 ectopic germ cell programmed cell death GO:0035234 9.46 IL1A IL1B
17 negative regulation of coagulation GO:0050819 9.43 PROC PROCR
18 negative regulation of blood coagulation GO:0030195 9.43 PROC SERPINE1 THBD
19 fever generation GO:0001660 9.13 IL1A IL1B IL1RN
20 hemostasis GO:0007599 9.02 F5 PROC PROCR SERPINC1 THBD

Molecular functions related to Meningococcemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CCL5 IL1A IL1B IL1RN
2 interleukin-1 receptor binding GO:0005149 8.8 IL1A IL1B IL1RN
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Sources for Meningococcemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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