MCID: MNN021
MIFTS: 37

Meningococcemia

Categories: Rare diseases

Aliases & Classifications for Meningococcemia

MalaCards integrated aliases for Meningococcemia:

Name: Meningococcemia 52 54 71

Classifications:



External Ids:

UMLS 71 C0025306

Summaries for Meningococcemia

MalaCards based summary : Meningococcemia is related to meningococcal meningitis and neisseria meningitidis infection. An important gene associated with Meningococcemia is BPI (Bactericidal Permeability Increasing Protein), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and brain, and related phenotypes are Increased replication of vaccinia virus (VACV) and cardiovascular system

Wikipedia : 74 Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed... more...

Related Diseases for Meningococcemia

Diseases related to Meningococcemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 256)
# Related Disease Score Top Affiliating Genes
1 meningococcal meningitis 32.8 MBL2 CFP
2 neisseria meningitidis infection 31.3 MBL2 IL1RN CFP
3 vasculitis 30.5 THBD MBL2 BPI
4 bacterial meningitis 30.5 MBL2 IL1B CFP
5 toxic shock syndrome 30.3 SERPINC1 IL1RN IL1B BPI
6 meningitis 30.3 MBL2 IL1B CFP CCL5
7 purpura 30.1 THBD SERPINC1 PROCR PROC
8 purpura fulminans 30.0 SERPINC1 PROCR PROC F5
9 osteomyelitis 29.4 IL1RN IL1B IL1A CCL5
10 arthritis 29.4 IL1RN IL1B IL1A CCL5
11 disseminated intravascular coagulation 29.3 THBD SERPINE1 SERPINC1 PROCR F5
12 peritonitis 29.3 SERPINE1 IL1B CCL5
13 intracranial hypertension 29.3 SERPINE1 SERPINC1 IL1B F5
14 respiratory failure 29.1 THBD IL1RN IL1B CCL5
15 blood coagulation disease 28.8 THBD SERPINE1 SERPINC1 F5
16 vascular disease 28.8 THBD SERPINE1 SERPINC1 F5
17 thrombocytopenia 28.3 THBD SERPINE1 SERPINC1 IL1RN IL1B IL1A
18 protein c deficiency 27.6 THBD SERPINE1 SERPINC1 PROCR PROC F5
19 myocardial infarction 26.9 THBD SERPINE1 SERPINC1 PROCR IL1RN IL1B
20 meningococcal infection 11.6
21 dengue disease 11.2
22 exanthem 10.6
23 anthracosilicosis 10.4 IL1B CFP
24 waterhouse-friderichsen syndrome 10.4
25 systemic onset juvenile idiopathic arthritis 10.4 IL1RN IL1B
26 myocarditis 10.4
27 prosthetic joint infection 10.4 MBL2 IL1B
28 indolent myeloma 10.4 IL1RN IL1B
29 limbal stem cell deficiency 10.4 IL1B IL1A
30 mannose-binding lectin deficiency 10.3 MBL2 CFP
31 bacteremia 2 10.3 MBL2 BPI
32 irritant dermatitis 10.3 IL1B IL1A
33 cervical adenitis 10.3 IL1RN IL1B
34 pars planitis 10.3 IL1RN IL1A
35 periapical periodontitis 10.3 IL1B IL1A
36 complement component 3 deficiency 10.3 MBL2 CFP
37 laryngitis 10.3 IL1B IL1A
38 paratyphoid fever 10.3 IL1B IL1A
39 schnitzler syndrome 10.3 IL1RN IL1B
40 neonatal stroke 10.3 SERPINE1 PROC
41 complement component 7 deficiency 10.3
42 pericarditis 10.3
43 complement deficiency 10.2
44 acanthamoeba keratitis 10.2 MBL2 F5
45 scabies 10.2 MBL2 IL1A CFP
46 root resorption 10.2 IL1RN IL1B IL1A
47 aseptic meningitis 10.2 IL1RN IL1B IL1A
48 glomerulonephritis 10.2 MBL2 IL1B CFP
49 somatoform disorder 10.2 IL1RN IL1B IL1A
50 aphthous stomatitis 10.2 IL1RN IL1B IL1A

Graphical network of the top 20 diseases related to Meningococcemia:



Diseases related to Meningococcemia

Symptoms & Phenotypes for Meningococcemia

GenomeRNAi Phenotypes related to Meningococcemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased replication of vaccinia virus (VACV) GR00362-A 9.02 MBL2 PROC SERPINC1 SERPINE1 THBD

MGI Mouse Phenotypes related to Meningococcemia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 CFP F5 IL1A IL1B IL1RN PROC
2 hematopoietic system MP:0005397 9.85 CCL5 IL1A IL1B IL1RN MBL2 PROC
3 homeostasis/metabolism MP:0005376 9.7 CFP F5 IL1A IL1B IL1RN MBL2
4 immune system MP:0005387 9.36 CCL5 CFP IL1A IL1B IL1RN MBL2

Drugs & Therapeutics for Meningococcemia

Drugs for Meningococcemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2, Phase 3
2 Immunologic Factors Phase 2, Phase 3
3 Pharmaceutical Solutions Phase 2, Phase 3
4 Immunoglobulins Phase 2
5 Antibodies Phase 2

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Immunogenicity and Safety of Meningococcal (Groups A, C, Y, and W-135) Diphtheria Toxoid Conjugate Vaccine (Menactra®) in Adolescents in the US When Administered Concomitantly With Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed (Tdap Vaccine) Completed NCT00777257 Phase 4
2 Evaluation of the Response to a Single Dose of Menactra® in Children Aged 5 to 8 Years Who Had Previously Received Two Doses of Quadrivalent (A, C, Y, W-135) Meningococcal Polysaccharide Vaccine Before Age 2 Years in Saudi Arabia Completed NCT00539032 Phase 3
3 A Randomized Observer-blinded Controlled Non-inferiority Trial to Evaluate the Immunogenicity of Locally Manufactured Meningococcal ACWY Vaccine 'Ingovax ACWY' in Bangladeshi Healthy Adults. Completed NCT03263403 Phase 2, Phase 3
4 Antibody Responses to a Booster Dose of an Experimental Tetravalent (A, C, Y, and W-135) Meningococcal Diphtheria Toxoid Conjugate Vaccine, Menactra® in Adolescents Who Previously Received Menomune® or Menactra® Completed NCT00777790 Phase 2
5 Antibody Responses for Serogroup C After One Dose of an Experimental Tetravalent (A, C, Y, and W-135) Meningococcal Diphtheria Toxoid Conjugate Vaccine Versus a Non-meningococcal Control Vaccine in Children Who Have Previously Received a Monovalent Meningococcal C Conjugate Vaccine Completed NCT00771849 Phase 2
6 Antibody Responses to a Reduced Dose of Menomune® in Children Who Previously Received an Experimental Tetravalent (A, C, Y, and W-135) Meningococcal Diphtheria Toxoid Conjugate Vaccine, TetraMenD Completed NCT00772070 Phase 2
7 Antibody Persistence and Booster Dose Response in Subjects Who Received Menactra® (Meningococcal [Groups A, C, Y, and W-135] Polysaccharide Diphtheria Toxoid Conjugate Vaccine) Three Years Earlier in Study MTA26 Completed NCT00700713 Phase 2
8 A Phase 2 Double Blind Study to Evaluate Safety and Immunogenicity of Meningococcal Meningitis Serogroups A, C, Y & W-135 Polysaccharide Diphtheria Toxoid Conjugate Vaccine (NmVac4-A/C/Y/W-135-DT™) Compared With a Licensed Vaccine Completed NCT01897402 Phase 2
9 Antibody Responses Following Meningococcal Tetravalent (A, C, Y, and W-135) Conjugate Vaccination in Healthy Adults Who Were Either Previously Vaccinated With Unconjugated Meningococcal Polysaccharide (Serogroups A, C or Serogroups A, C, Y, and W-135) Vaccine or Not Vaccinated With Meningococcal Vaccine Terminated NCT00772629 Phase 2
10 A Double-Blind, Randomized, Controlled, Two Arm Phase 1 Clinical Trial of the Safety and Immunogenicity of Group A, C, Y & W-135 Meningococcal Polysaccharide DT Conjugate Vaccine: NmVac4-A/C/Y/W-135-DT™ Completed NCT01482052 Phase 1
11 Clinical and Laboratorial Factors Associated With the Severity of Meningococcal Disease Completed NCT01133834

Search NIH Clinical Center for Meningococcemia

Genetic Tests for Meningococcemia

Anatomical Context for Meningococcemia

MalaCards organs/tissues related to Meningococcemia:

40
Skin, Kidney, Brain, Lung, Adrenal Gland, Endothelial, Bone

Publications for Meningococcemia

Articles related to Meningococcemia:

(show top 50) (show all 691)
# Title Authors PMID Year
1
Soluble thrombomodulin, plasma-derived unactivated protein C, and recombinant human activated protein C in sepsis. 54 61
12004254 2002
2
Dysfunction of endothelial protein C activation in severe meningococcal sepsis. 54 61
11496851 2001
3
Bactericidal/permeability-increasing protein--lessons learned from the phase III, randomized, clinical trial of rBPI21 for adjunctive treatment of children with severe meningococcemia. 54 61
11445748 2001
4
Protein C replacement in severe meningococcemia: rationale and clinical experience. 54 61
11303270 2001
5
An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia. 54 61
11090052 2000
6
Meningococcemia and purpura fulminans in adults: acute deficiencies of proteins C and S and early treatment with antithrombin III concentrates. 54 61
2139671 1990
7
First case report of fulminant septic shock from meningococcemia associated with Cryptococcus neoformans coinfection in an immunocompetent patient. 61
31660289 2019
8
Myocarditis in fulminant meningococcemia. 61
31134311 2019
9
Acute abdominal pain as the initial manifestation of meningococcemia in adult patient. 61
31735588 2019
10
A case report of multiple cerebral abscess formation complicating serogroup B Neisseria meningitidis meningitis. 61
31638913 2019
11
50 Years Ago in TheJournal ofPediatrics: Heparin Therapy in Fulminant Meningococcemia. 61
31439162 2019
12
Chronic meningococcemia: a report of 26 cases and literature review. 61
30341638 2019
13
Renal histological findings in a patient with acute renal injury associated with purpura fulminans: a case report. 61
30222177 2019
14
The rash with maculopapules and fever in children. 61
30981292 2019
15
The rash with maculopapules and fever in adults. 61
30981291 2019
16
Primary Meningococcal Septic Arthritis Case Report and Literature Review of an Unusual Manifestation of Meningococcal Disease. 61
31128585 2019
17
The Brief Case: Meningococcemia Leading to a Diagnosis of Complement Deficiency in a 23-Month-Old. 61
30700562 2019
18
Closing the Brief Case: Meningococcemia Leading to a Diagnosis of Complement Deficiency in a 23-Month-Old. 61
30700563 2019
19
Chronic meningococcemia. 61
30788217 2019
20
The Pathogenic Neisseria Use a Streamlined Set of Peptidoglycan Degradation Proteins for Peptidoglycan Remodeling, Recycling, and Toxic Fragment Release. 61
30766523 2019
21
First Report of a Disease by Rhazes 10 Centuries Ago. 61
30774840 2019
22
Analysis of social and medical portrait of children with pertussis, meningococcal infectious, scarlet fever and estimation of their assigned pharmacotherapy. 61
31622270 2019
23
Invasive meningococcal disease epidemiology and characterization of Neisseria meningitidis serogroups, sequence types, and clones; implication for use of meningococcal vaccines. 61
30156954 2019
24
Meningococcemia: rare but life-threatening. 61
30337290 2018
25
Invasive Meningococcal Disease due to group C N. meningitidis ST11 (cc11): The Tuscany cluster 2015-2016. 61
30172636 2018
26
Fever with Rashes. 61
28940140 2018
27
Meningococcal meningitis with neurological complications and meningococcemia due to serogroup W sequence type 11 complex. 61
29373268 2018
28
Combined effect of PCV10 and meningococcal C conjugate vaccination on meningitis mortality among children under five years of age in Brazil. 61
29068749 2018
29
Progress toward the global control of Neisseria meningitidis: 21st century vaccines, current guidelines, and challenges for future vaccine development. 61
29543582 2018
30
Fatal meningococcemia mimicking intra-abdominal emergency. 61
29260273 2018
31
Fatal meningococcal septicemia without meningeal signs, contribution of the peripheral smear in diagnosis: Report of a case. 61
29676380 2018
32
An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans. 61
29630665 2018
33
[Neisseria meningitidis pneumonia. A case report]. 61
29999162 2018
34
Pericarditis due to Neisseria meningitidis serogroup W135. 61
29942749 2018
35
Cerebral Venous Sinus Thrombosis in a Patient with Meningococcal Meningitis. 61
29468001 2018
36
Chronic meningococcemia presenting with recurrent painful rash and poly-arthralgia without fever. 61
30191127 2018
37
Meningococcemia complicated by myocarditis in a 16-year-old young man: a case report. 61
30050613 2018
38
No Neck Pain: Meningococcemia. 61
28821376 2018
39
Fulminant meningococcemia in adult caucasian male. 61
30267515 2018
40
Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease Treatment. 61
29362231 2018
41
Meningococcemia Masquerading as a Nonspecific Flu-Like Syndrome. 61
30519492 2018
42
Fatal meningococcemia due to Neisseria meningitidis serogroup Y in a vaccinated child receiving eculizumab. 61
29883245 2018
43
Reply letter to "Fatal meningococcemia due to Neisseria meningitidis serogroup Y in a vaccinated child receiving eculizumab". 61
29923779 2018
44
Genomic Characterization of Urethritis-Associated Neisseria meningitidis Shows that a Wide Range of N. meningitidis Strains Can Cause Urethritis. 61
28904187 2017
45
Peripheral blood vessels are a niche for blood-borne meningococci. 61
29099305 2017
46
Meningococcal disease, a clinical and epidemiological review. 61
29203096 2017
47
Atriobronchial Fistula Complicated by Septic Cerebral Air Emboli After Pulmonary Vein Ablation. 61
28441232 2017
48
Arthritis secondary to meningococcal disease: A case series of 7 patients. 61
28723791 2017
49
Purpura Fulminans in Acute Meningococcemia. 61
28236134 2017
50
Successful treatment of a patient with ethylmalonic encephalopathy by intravenous N-acetylcysteine. 61
27830356 2017

Variations for Meningococcemia

Expression for Meningococcemia

Search GEO for disease gene expression data for Meningococcemia.

Pathways for Meningococcemia

Pathways related to Meningococcemia according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 THBD SERPINE1 SERPINC1 PROCR PROC F5
2
Show member pathways
11.96 THBD PROCR PROC
3 11.91 IL1RN IL1B IL1A
4
Show member pathways
11.91 SERPINE1 IL1RN IL1B IL1A
5 11.83 THBD IL1B IL1A
6 11.7 SERPINE1 IL1B IL1A
7
Show member pathways
11.63 THBD SERPINE1 SERPINC1 PROCR PROC F5
8 11.62 IL1B IL1A CCL5
9 11.56 THBD SERPINE1 IL1B IL1A
10 11.46 IL1RN IL1B CCL5
11 11.33 THBD SERPINE1 SERPINC1 PROCR PROC MBL2
12 11.15 IL1RN IL1B IL1A CCL5
13 11.04 IL1B IL1A CCL5
14 11.01 IL1B IL1A
15 10.25 IL1B IL1A

GO Terms for Meningococcemia

Cellular components related to Meningococcemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 SERPINE1 SERPINC1 PROCR PROC MBL2 IL1RN
2 collagen-containing extracellular matrix GO:0062023 9.56 SERPINE1 SERPINC1 MBL2 CFP
3 endoplasmic reticulum lumen GO:0005788 9.46 SERPINC1 PROC F5 CFP
4 extracellular space GO:0005615 9.44 THBD SERPINE1 SERPINC1 PROCR PROC MBL2

Biological processes related to Meningococcemia according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.87 IL1RN IL1B IL1A CCL5
2 cytokine-mediated signaling pathway GO:0019221 9.83 IL1RN IL1B IL1A CCL5
3 immune response GO:0006955 9.8 IL1RN IL1B IL1A CFP CCL5 BPI
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.78 IL1RN IL1B IL1A
5 positive regulation of angiogenesis GO:0045766 9.76 SERPINE1 IL1B IL1A
6 cellular response to lipopolysaccharide GO:0071222 9.73 SERPINE1 IL1RN IL1B IL1A
7 interleukin-1-mediated signaling pathway GO:0070498 9.72 IL1RN IL1B IL1A
8 positive regulation of JNK cascade GO:0046330 9.69 IL1RN IL1B IL1A
9 positive regulation of interleukin-6 production GO:0032755 9.63 IL1RN IL1B IL1A
10 positive regulation of vascular endothelial growth factor production GO:0010575 9.61 IL1B IL1A
11 positive regulation of mitotic nuclear division GO:0045840 9.6 IL1B IL1A
12 positive regulation of interleukin-8 production GO:0032757 9.59 SERPINE1 IL1B
13 positive regulation of monocyte chemotaxis GO:0090026 9.58 SERPINE1 CCL5
14 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.56 IL1B IL1A
15 neutrophil chemotaxis GO:0030593 9.56 IL1RN IL1B IL1A CCL5
16 negative regulation of fibrinolysis GO:0051918 9.54 THBD SERPINE1
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.54 IL1B CCL5 BPI
18 negative regulation of coagulation GO:0050819 9.49 PROCR PROC
19 ectopic germ cell programmed cell death GO:0035234 9.48 IL1B IL1A
20 fever generation GO:0001660 9.4 IL1B IL1A
21 blood coagulation GO:0007596 9.35 THBD SERPINC1 PROCR PROC F5
22 negative regulation of blood coagulation GO:0030195 9.33 THBD SERPINE1 PROC
23 hemostasis GO:0007599 9.02 THBD SERPINC1 PROCR PROC F5

Molecular functions related to Meningococcemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 IL1RN IL1B IL1A CCL5
2 interleukin-1 receptor binding GO:0005149 8.8 IL1RN IL1B IL1A

Sources for Meningococcemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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