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MCID: MNN021
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Meningococcemia

Categories: Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Meningococcemia

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MalaCards integrated aliases for Meningococcemia:

Name: Meningococcemia 54 56 74

Classifications:

MalaCards categories:
Global: Rare diseases
See all MalaCards categories (disease lists)


External Ids:

UMLS 74 C0025306
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Summaries for Meningococcemia

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MalaCards based summary : Meningococcemia is related to meningococcal meningitis and meningitis. An important gene associated with Meningococcemia is BPI (Bactericidal Permeability Increasing Protein), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and cardiovascular system

Wikipedia : 77 Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed... more...

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Related Diseases for Meningococcemia

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Diseases related to Meningococcemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 meningococcal meningitis 32.7 CFP MBL2
2 meningitis 30.9 CFP IL1B MBL2
3 purpura fulminans 30.5 PROC PROCR SERPINC1
4 neisseria meningitidis infection 30.3 CFP IL1RN MBL2
5 purpura 30.1 PROC PROCR SERPINC1 THBD
6 disseminated intravascular coagulation 29.8 F5 SERPINC1 SERPINE1 THBD
7 protein c deficiency 29.2 F5 PROC SERPINC1 THBD
8 myocardial infarction 27.9 CCL5 F5 IL1B PROCR SERPINC1 SERPINE1
9 meningococcal infection 11.4
10 dengue disease 11.1
11 neonatal stroke 10.3 PROC SERPINE1
12 mannose-binding lectin deficiency 10.3 CFP MBL2
13 bacteremia 2 10.3 BPI MBL2
14 waterhouse-friderichsen syndrome 10.3
15 schnitzler syndrome 10.3 IL1B IL1RN
16 streptococcal meningitis 10.3 CFP MBL2
17 prosthetic joint infection 10.3 IL1B MBL2
18 3mc syndrome 10.3 CFP MBL2
19 chronic follicular conjunctivitis 10.3 IL1A IL1B
20 osteosclerotic myeloma 10.2 IL1B IL1RN
21 inferior vena cava interruption 10.2 F5 SERPINE1
22 amaurosis fugax 10.2 F5 SERPINE1
23 acanthamoeba keratitis 10.2 F5 MBL2
24 irritant dermatitis 10.2 IL1A IL1B
25 cryptogenic cirrhosis 10.2 F5 SERPINE1
26 scabies 10.2 CFP IL1A MBL2
27 limbal stem cell deficiency 10.2 IL1A IL1B
28 fibrinolytic defect 10.2 SERPINC1 SERPINE1
29 quebec platelet disorder 10.1 F5 SERPINE1
30 vulvar vestibulitis syndrome 10.1 IL1B IL1RN MBL2
31 aspirin allergy 10.1 SERPINC1 SERPINE1
32 argentine hemorrhagic fever 10.1 SERPINC1 SERPINE1
33 complement deficiency 10.1
34 myocarditis 10.1
35 blue toe syndrome 10.1 SERPINC1 SERPINE1
36 root resorption 10.1 IL1A IL1B IL1RN
37 factor xiii deficiency 10.1 F5 SERPINE1
38 somatoform disorder 10.1 IL1A IL1B IL1RN
39 subendocardial myocardial infarction 10.1 SERPINC1 SERPINE1
40 silicosis 10.1 IL1A IL1B IL1RN
41 aggressive periodontitis 10.1 IL1A IL1B IL1RN
42 chorioamnionitis 10.1 IL1A IL1B IL1RN
43 osteomyelitis 10.1 IL1A IL1B IL1RN
44 bone inflammation disease 10.1 IL1A IL1B IL1RN
45 livedoid vasculitis 10.1 SERPINC1 SERPINE1
46 catastrophic antiphospholipid syndrome 10.1 F5 PROC SERPINE1
47 burns 10.1 IL1B SERPINC1
48 bacterial vaginosis 10.1 IL1A IL1B MBL2
49 periodontal disease 10.1 IL1A IL1B IL1RN
50 spinal cord infarction 10.0 F5 SERPINC1

Graphical network of the top 20 diseases related to Meningococcemia:



Diseases related to Meningococcemia
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Symptoms & Phenotypes for Meningococcemia

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GenomeRNAi Phenotypes related to Meningococcemia according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.02 MBL2 PROC SERPINC1 SERPINE1 THBD

MGI Mouse Phenotypes related to Meningococcemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 CFP F5 IL1A IL1B IL1RN PROC
2 hematopoietic system MP:0005397 9.85 CCL5 IL1A IL1B IL1RN MBL2 PROC
3 homeostasis/metabolism MP:0005376 9.7 CFP F5 IL1A IL1B IL1RN MBL2
4 immune system MP:0005387 9.36 CCL5 CFP IL1A IL1B IL1RN MBL2
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Drugs & Therapeutics for Meningococcemia

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Drugs for Meningococcemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 3,Phase 2
2 Immunologic Factors Phase 4,Phase 3,Phase 2
3
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
4
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
5 Antibodies Phase 2
6 Immunoglobulins Phase 2
7 Anti-Inflammatory Agents Phase 2
8 Hydrocortisone-17-butyrate Phase 2
9 Hydrocortisone 17-butyrate 21-propionate Phase 2
10 Hydrocortisone hemisuccinate Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Menactra® in US Adolescents When Administered Concomitantly With Tdap Vaccine Completed NCT00777257 Phase 4
2 Immunology and Safety of Menactra® in Children in Saudi Arabia Completed NCT00539032 Phase 3
3 Study of a Booster Dose of Meningococcal Diphtheria Toxoid Conjugate Vaccine in Adolescents Completed NCT00777790 Phase 2
4 Study of Antibody Responses After a Dose of Tetravalent Meningococcal Diphtheria Conjugate Vaccine in Children Completed NCT00771849 Phase 2
5 Antibody Persistence and Booster Dose Response in Subjects Who Received Menactra® Three Years Earlier in Study MTA26 Completed NCT00700713 Phase 2
6 Study of Reduced Dose of Menomune® in Children Who Previously Received Meningococcal Diphtheria Toxoid Conjugate Vaccine Completed NCT00772070 Phase 2
7 Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis - a Randomised Pilot Study Completed NCT00732277 Phase 2 hydrocortisone
8 Antibody Responses Following Meningococcal Tetravalent (A, C, Y, and W-135) Conjugate Vaccination in Healthy Adults Terminated NCT00772629 Phase 2
9 Correlation Between Cytokines and the Severity of Meningococcal Disease Completed NCT01133834
10 Petechiae In Children (PIC) Study: Defining A Clinical Decision Rule for The Management Of Fever and Non-Blanching Rashes In Children Including The Role Of Point Of Care Testing For Procalcitonin & Neisseria Meningitidis DNA. Recruiting NCT03378258

Search NIH Clinical Center for Meningococcemia

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Genetic Tests for Meningococcemia

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Anatomical Context for Meningococcemia

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MalaCards organs/tissues related to Meningococcemia:

42
Bone, Testes, Skin, Colon, Heart, Endothelial, Atrioventricular Node
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Publications for Meningococcemia

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Articles related to Meningococcemia:

(show top 50) (show all 321)
# Title Authors Year
1
The Brief Case: Meningococcemia Leading to a Diagnosis of Complement Deficiency in a 23-Month-Old. ( 30700562 )
2019
2
Closing the Brief Case: Meningococcemia Leading to a Diagnosis of Complement Deficiency in a 23-Month-Old. ( 30700563 )
2019
3
Chronic meningococcemia: a report of 26 cases and literature review. ( 30341638 )
2019
4
Chronic meningococcemia. ( 30788217 )
2019
5
Meningococcal meningitis with neurological complications and meningococcemia due to serogroup W sequence type 11 complex. ( 29373268 )
2018
6
No Neck Pain: Meningococcemia. ( 28821376 )
2018
7
Fatal meningococcemia mimicking intra-abdominal emergency. ( 29260273 )
2018
8
Fatal meningococcemia due to Neisseria meningitidis serogroup Y in a vaccinated child receiving eculizumab. ( 29883245 )
2018
9
Reply letter to "Fatal meningococcemia due to Neisseria meningitidis serogroup Y in a vaccinated child receiving eculizumab". ( 29923779 )
2018
10
Meningococcemia complicated by myocarditis in a 16-year-old young man: a case report. ( 30050613 )
2018
11
Chronic meningococcemia presenting with recurrent painful rash and poly-arthralgia without fever. ( 30191127 )
2018
12
Fulminant meningococcemia in adult caucasian male. ( 30267515 )
2018
13
Meningococcemia: rare but life-threatening. ( 30337290 )
2018
14
Meningococcemia Masquerading as a Nonspecific Flu-Like Syndrome. ( 30519492 )
2018
15
Meningococcemia in vaccinated patient under treatment with eculizumab. ( 26994815 )
2017
16
Purpura Fulminans in Acute Meningococcemia. ( 28236134 )
2017
17
Fulminant meningococcemia. ( 28271045 )
2017
18
A Case of Fulminant Meningococcemia: It Is All in the Complement. ( 28808592 )
2017
19
Late Sequel of Meningococcemia: Skeletal Dysplasia. ( 26960252 )
2016
20
Meningococcemia in Adults: A Review of the Literature. ( 26984070 )
2016
21
Experimental Evidence of Bacterial Colonization of Human Coronary Microvasculature and Myocardial Tissue during Meningococcemia. ( 27481255 )
2016
22
Chronic meningococcemia in an immunocompetent child. ( 27535891 )
2016
23
Meningococcal meningitis with meningococcemia: a rare sporadic case in an elderly patient with no history of contact with infected individuals. ( 25420647 )
2015
24
Right lower quadrant abdominal pain, fever, and hypotension: an atypical presentation of meningococcemia. ( 25825033 )
2015
25
Chronic meningococcemia presenting as a recurrent painful rash without fever in a teenage girl. ( 25970111 )
2015
26
Meningococcemia Presenting as a Myocardial Infarction. ( 26640720 )
2015
27
Corticosteroid-induced meningococcal meningitis in a patient with chronic meningococcemia. ( 24577072 )
2014
28
MBL2 deficiency is associated with higher genomic bacterial loads during meningococcemia in young children. ( 24977653 )
2014
29
Meningococcemia and heparin-induced thrombocytopenia: a dangerous combination. ( 23061921 )
2013
30
Meningococcemia due to the 2000 Hajj-associated outbreak strain (Serogroup W-135 ST-11) with immunoreactive complications. ( 24047748 )
2013
31
Meningococcemia: the pediatric orthopedic sequelae. ( 23622829 )
2013
32
Pathogenesis of meningococcemia. ( 23732856 )
2013
33
Purpura fulminans caused by meningococcemia in an infant. ( 23921694 )
2013
34
Rapid recovery following fulminant meningococcemia complicated by myocarditis in a 15-year-old Nepalese girl: a case report. ( 23950664 )
2013
35
Meningococcemia presenting as acute painful mononeuritis multiplex. ( 22100105 )
2012
36
Chronic meningococcemia cutaneous lesions involve meningococcal perivascular invasion through the remodeling of endothelial barriers. ( 22412064 )
2012
37
Using the internet to trace contacts of a fatal meningococcemia case-New York City, 2010. ( 22635194 )
2012
38
A baby with meningococcemia and septic shock. ( 22689868 )
2012
39
Rash in meningococcemia. ( 22892518 )
2012
40
Purpura fulminans from meningococcemia mimicking Stevens-Johnson syndrome in an adult patient taking etanercept. ( 23247497 )
2012
41
Atypical presentation of fatal meningococcemia: peritonitis and paradoxical centrifugal purpura fulminans of late onset. ( 21075588 )
2011
42
Association of chronic meningococcemia with infection by meningococci with underacylated lipopolysaccharide. ( 21459106 )
2011
43
Fatal meningococcemia. ( 23882342 )
2011
44
Clinical images: Purpura fulminans caused by meningococcemia. ( 19858241 )
2010
45
Dermacase. Question: Can you identify this condition? Diagnosis: Meningococcemia. ( 20841592 )
2010
46
Orthopaedic sequelae of childhood meningococcemia: management considerations and outcome. ( 20844162 )
2010
47
Severe rhabdomyolysis associated in meningococcemia. ( 20927300 )
2010
48
Fever, abdominal pain, and leukopenia in a 13-year-old: a case-based review of meningococcemia. ( 18657927 )
2009
49
Giant condyloma with demise secondary to meningococcemia in an infant boy. ( 19596116 )
2009
50
Application of the vacuum-assisted closure in pediatric patients with orthopedic sequelae of meningococcemia: report of a case successfully treated. ( 19620896 )
2009
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Variations for Meningococcemia

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Expression for Meningococcemia

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Search GEO for disease gene expression data for Meningococcemia.
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Pathways for Meningococcemia

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Pathways related to Meningococcemia according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 67
Show member pathways
 13.03 F5 PROC PROCR SERPINC1 SERPINE1 THBD
2
Collagen chain trimerization 67
Show member pathways
 12.58 F5 PROC SERPINC1 THBD
3
Cell surface interactions at the vascular wall 67
Show member pathways
 11.97 PROC PROCR THBD
4
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.91 IL1A IL1B IL1RN
5
IL-1 Family Signaling Pathways 66
Show member pathways
 11.91 IL1A IL1B IL1RN SERPINE1
6
Fluid shear stress and atherosclerosis 38
11.83 IL1A IL1B THBD
7
Senescence and Autophagy in Cancer 1
11.7 IL1A IL1B SERPINE1
8
Formation of Fibrin Clot (Clotting Cascade) 67
Show member pathways
 11.63 F5 PROC PROCR SERPINC1 SERPINE1 THBD
9
Rheumatoid arthritis 38
11.59 CCL5 IL1A IL1B
10
AGE-RAGE signaling pathway in diabetic complications 38
11.56 IL1A IL1B SERPINE1 THBD
11
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.46 CCL5 IL1B IL1RN
12
Complement and coagulation cascades 1 38
11.31 F5 MBL2 PROC PROCR SERPINC1 SERPINE1
13
Interleukin-10 signaling 67
11.15 CCL5 IL1A IL1B IL1RN
14
Prion diseases 38
11.04 CCL5 IL1A IL1B
15
Cytokines and Inflammatory Response 1
11.01 IL1A IL1B
16
G-protein signaling_RhoB regulation pathway 23
10.97 CCL5 IL1A IL1B
17
Interleukin-1 processing 67
10.25 IL1A IL1B
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GO Terms for Meningococcemia

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Cellular components related to Meningococcemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 BPI CCL5 CFP F5 IL1A IL1B
2 endoplasmic reticulum lumen GO:0005788 9.46 CFP F5 PROC SERPINC1
3 extracellular space GO:0005615 9.44 BPI CCL5 CFP F5 IL1A IL1B

Biological processes related to Meningococcemia according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.84 CCL5 IL1A IL1B IL1RN
2 cytokine-mediated signaling pathway GO:0019221 9.8 CCL5 IL1A IL1B IL1RN
3 regulation of signaling receptor activity GO:0010469 9.77 CCL5 IL1A IL1B IL1RN SERPINE1
4 cellular response to lipopolysaccharide GO:0071222 9.74 IL1B IL1RN SERPINE1
5 positive regulation of angiogenesis GO:0045766 9.73 IL1A IL1B SERPINE1
6 immune response GO:0006955 9.73 BPI CCL5 CFP IL1A IL1B IL1RN
7 neutrophil chemotaxis GO:0030593 9.65 CCL5 IL1B IL1RN
8 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.6 IL1A IL1B
9 positive regulation of interleukin-8 production GO:0032757 9.59 IL1B SERPINE1
10 positive regulation of mitotic nuclear division GO:0045840 9.58 IL1A IL1B
11 positive regulation of vascular endothelial growth factor production GO:0010575 9.58 IL1A IL1B
12 interleukin-1-mediated signaling pathway GO:0070498 9.58 IL1A IL1B IL1RN
13 positive regulation of monocyte chemotaxis GO:0090026 9.55 CCL5 SERPINE1
14 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.52 IL1A IL1B
15 negative regulation of fibrinolysis GO:0051918 9.51 SERPINE1 THBD
16 ectopic germ cell programmed cell death GO:0035234 9.46 IL1A IL1B
17 negative regulation of coagulation GO:0050819 9.43 PROC PROCR
18 blood coagulation GO:0007596 9.35 F5 PROC PROCR SERPINC1 THBD
19 negative regulation of blood coagulation GO:0030195 9.33 PROC SERPINE1 THBD
20 fever generation GO:0001660 9.32 IL1A IL1B
21 hemostasis GO:0007599 9.02 F5 PROC PROCR SERPINC1 THBD

Molecular functions related to Meningococcemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 CCL5 CFP F5 IL1A IL1B IL1RN
2 cytokine activity GO:0005125 9.26 CCL5 IL1A IL1B IL1RN
3 interleukin-1 receptor binding GO:0005149 8.8 IL1A IL1B IL1RN
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Sources for Meningococcemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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