MCID: MNN021
MIFTS: 30

Meningococcemia

Categories: Rare diseases
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Aliases & Classifications for Meningococcemia

MalaCards integrated aliases for Meningococcemia:

Name: Meningococcemia 19 75 53 71 75

Classifications:



External Ids:

UMLS 71 C0025306

Summaries for Meningococcemia

MalaCards based summary: Meningococcemia is related to purpura and toxic shock syndrome. An important gene associated with Meningococcemia is BPI (Bactericidal Permeability Increasing Protein), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Immunologic Factors and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, skin and atrioventricular node.

Wikipedia: 75 Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed... more...

Related Diseases for Meningococcemia

Diseases related to Meningococcemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 204)
# Related Disease Score Top Affiliating Genes
1 purpura 30.9 THBD SERPINC1
2 toxic shock syndrome 30.5 SERPINC1 BPI
3 disseminated intravascular coagulation 30.0 THBD SERPINC1 PROCR F5
4 purpura fulminans 29.9 THBD SERPINC1 PROCR F5
5 intracranial hypertension 29.8 SERPINC1 F5
6 hemoglobinuria 29.5 THBD SERPINC1
7 vascular disease 29.1 THBD SERPINC1 F5
8 malaria 29.0 THBD SERPINC1 PROCR CCL5
9 acute myocardial infarction 29.0 THBD SERPINC1 CCL5
10 respiratory failure 29.0 THBD SERPINC1 CCL5
11 protein c deficiency 28.9 THBD SERPINC1 PROCR F5
12 myocardial infarction 28.2 THBD SERPINC1 PROCR F5 CCL5
13 meningococcal infection 11.1
14 meningococcal meningitis 11.1
15 exanthem 10.5
16 meningitis 10.5
17 waterhouse-friderichsen syndrome 10.3
18 myocarditis 10.3
19 bacteremia 2 10.2
20 vasculitis 10.2
21 complement component 7 deficiency 10.2
22 pericarditis 10.2
23 acute kidney failure 10.1
24 complement deficiency 10.1
25 osteonecrosis 10.1
26 kidney disease 10.1
27 bacterial meningitis 10.1
28 gastroenteritis 10.0
29 shwartzman phenomenon 10.0
30 conjunctivitis 10.0
31 septic arthritis 10.0
32 tenosynovitis 10.0
33 prothrombin deficiency, congenital 10.0 SERPINC1 F5
34 sagittal sinus thrombosis 10.0 SERPINC1 F5
35 alpha-2-plasmin inhibitor deficiency 10.0 THBD SERPINC1
36 central retinal vein occlusion 10.0 SERPINC1 F5
37 factor v deficiency 10.0 SERPINC1 F5
38 intracranial thrombosis 10.0 SERPINC1 F5
39 sneddon syndrome 10.0 SERPINC1 F5
40 factor xiii deficiency 10.0 SERPINC1 F5
41 thrombophlebitis 9.9 SERPINC1 F5
42 retinal vascular occlusion 9.9 SERPINC1 F5
43 antithrombin iii deficiency 9.9 SERPINC1 F5
44 factor x deficiency 9.9 SERPINC1 F5
45 factor xii deficiency 9.9 SERPINC1 F5
46 placental abruption 9.9 SERPINC1 F5
47 retinal artery occlusion 9.9 SERPINC1 F5
48 von willebrand's disease 9.9 SERPINC1 F5
49 pulmonary artery disease 9.9 THBD SERPINC1
50 factor viii deficiency 9.9 SERPINC1 F5

Graphical network of the top 20 diseases related to Meningococcemia:



Diseases related to Meningococcemia

Symptoms & Phenotypes for Meningococcemia

Drugs & Therapeutics for Meningococcemia

Drugs for Meningococcemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 3
2 Vaccines Phase 2
3 Immunoglobulins Phase 2
4 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Immunogenicity and Safety of Meningococcal (Groups A, C, Y, and W-135) Diphtheria Toxoid Conjugate Vaccine (Menactra®) in Adolescents in the US When Administered Concomitantly With Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed (Tdap Vaccine) Completed NCT00777257 Phase 4
2 Evaluation of the Response to a Single Dose of Menactra® in Children Aged 5 to 8 Years Who Had Previously Received Two Doses of Quadrivalent (A, C, Y, W-135) Meningococcal Polysaccharide Vaccine Before Age 2 Years in Saudi Arabia Completed NCT00539032 Phase 3
3 Antibody Persistence and Booster Dose Response in Subjects Who Received Menactra® (Meningococcal [Groups A, C, Y, and W-135] Polysaccharide Diphtheria Toxoid Conjugate Vaccine) Three Years Earlier in Study MTA26 Completed NCT00700713 Phase 2
4 Antibody Responses to a Booster Dose of an Experimental Tetravalent (A, C, Y, and W-135) Meningococcal Diphtheria Toxoid Conjugate Vaccine, Menactra® in Adolescents Who Previously Received Menomune® or Menactra® Completed NCT00777790 Phase 2
5 Antibody Responses to a Reduced Dose of Menomune® in Children Who Previously Received an Experimental Tetravalent (A, C, Y, and W-135) Meningococcal Diphtheria Toxoid Conjugate Vaccine, TetraMenD Completed NCT00772070 Phase 2
6 Antibody Responses for Serogroup C After One Dose of an Experimental Tetravalent (A, C, Y, and W-135) Meningococcal Diphtheria Toxoid Conjugate Vaccine Versus a Non-meningococcal Control Vaccine in Children Who Have Previously Received a Monovalent Meningococcal C Conjugate Vaccine Completed NCT00771849 Phase 2
7 Antibody Responses Following Meningococcal Tetravalent (A, C, Y, and W-135) Conjugate Vaccination in Healthy Adults Who Were Either Previously Vaccinated With Unconjugated Meningococcal Polysaccharide (Serogroups A, C or Serogroups A, C, Y, and W-135) Vaccine or Not Vaccinated With Meningococcal Vaccine Terminated NCT00772629 Phase 2
8 Clinical and Laboratorial Factors Associated With the Severity of Meningococcal Disease Completed NCT01133834

Search NIH Clinical Center for Meningococcemia

Genetic Tests for Meningococcemia

Anatomical Context for Meningococcemia

Organs/tissues related to Meningococcemia:

MalaCards : Adrenal Gland, Skin, Atrioventricular Node, Endothelial, B Cells, Kidney, Monocytes

Publications for Meningococcemia

Articles related to Meningococcemia:

(show top 50) (show all 719)
# Title Authors PMID Year
1
Soluble thrombomodulin, plasma-derived unactivated protein C, and recombinant human activated protein C in sepsis. 53 62
12004254 2002
2
Dysfunction of endothelial protein C activation in severe meningococcal sepsis. 53 62
11496851 2001
3
Bactericidal/permeability-increasing protein--lessons learned from the phase III, randomized, clinical trial of rBPI21 for adjunctive treatment of children with severe meningococcemia. 53 62
11445748 2001
4
Protein C replacement in severe meningococcemia: rationale and clinical experience. 53 62
11303270 2001
5
An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia. 53 62
11090052 2000
6
Meningococcemia and purpura fulminans in adults: acute deficiencies of proteins C and S and early treatment with antithrombin III concentrates. 53 62
2139671 1990
7
Neonatal meningococcal disease: an update. 62
33233995 2022
8
Immunoadsorption therapy for a meningococcemia patient with myocarditis, adrenal hemorrhage, and purpura fulminans: a case report. 62
34284056 2022
9
CRYOGLOBULINEMIC VASCULITIS. 62
36272838 2022
10
Sequelae at Hospital Discharge in 61 Children With Invasive Meningococcal Disease, Chile, 2009-2019. 62
35421054 2022
11
Meningococcal pericarditis caused by the MenW:cc11 strain in an older adult. 62
35904255 2022
12
SURGICAL TREATMENT OF VITREORETINAL COMPLICATIONS DURING DISSEMINATED INTRAVASCULAR COAGULATION SECONDARY TO MENINGOCOCCEMIA. 62
32568961 2022
13
Genetic workup as a complementary tool for the diagnosis of primary complement component deficiencies: a multicenter experience. 62
35118517 2022
14
Waterhouse-Friderichsen Syndrome with Bilateral Adrenal Hemorrhage Associated with Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia in an Adult Patient with History of Intravenous Drug Use. 62
35418553 2022
15
Staphylococcal endocarditis with meningitis and basal ganglia infarcts mimicking meningococcemia. 62
35261776 2022
16
Ethylmalonic encephalopathy masquerading as meningococcemia. 62
35165146 2022
17
Identification of the nasopharyngeal carriage of Neisseria meningitidis by 16S rRNA Gene sequencing in asymptomatic adolescents and young adults in Cartagena, Colombia (2019-2020). 62
35176256 2022
18
Purpuric Epiglottic Lesion in Purpura Fulminans Form of Meningococcemia. 62
32293909 2021
19
Investigation of primary immune deficiency after severe bacterial infection in children: A population-based study in western France. 62
33903000 2021
20
Clinical and molecular characterization of the first culture-confirmed pediatric fulminant meningococcemia case caused by a serogroup Y clonal complex 23 strain in China. 62
34147293 2021
21
Temporary Diverting End-Colostomy in Critically Ill Children with Severe Perianal Wound Infection. 62
33979821 2021
22
Fatal Serogroup B Meningococcemia in a Child Previously Vaccinated With MenACWY-DT Vaccine. 62
33853372 2021
23
Clinical and Laboratory Findings of 12 Children with Invasive Meningococcal Disease in Pediatric Intensive Care Unit. 62
34527377 2021
24
Invasive Meningococcal Disease Remains a Health Threat in Vietnam People's Army. 62
34916810 2021
25
A severe course of serogroup W meningococcemia in a patient with infantile nephropathic cystinosis. 62
32401678 2020
26
Pediatric bacterial meningitis and meningococcal disease profile in a Brazilian General Hospital. 62
32598866 2020
27
Acute abdominal pain as the initial manifestation of meningococcemia in adult patient. 62
31735588 2020
28
Meningococcemia Due to Nongroupable Neisseria meningitidis in a Splenectomized Child. 62
32301925 2020
29
The Inflammatory and Hemostatic Response in Sepsis and Meningococcemia. 62
32172820 2020
30
Neisseria meningitidis Induced Fatal Waterhouse-Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure. 62
32192003 2020
31
[Meningococcemia: Different Serotypes in the Same Region]. 62
32050887 2020
32
Chronic meningococcemia in a vertically HIV-infected adolescent. 62
32435587 2020
33
First case report of fulminant septic shock from meningococcemia associated with Cryptococcus neoformans coinfection in an immunocompetent patient. 62
31660289 2019
34
Myocarditis in fulminant meningococcemia. 62
31134311 2019
35
A case report of multiple cerebral abscess formation complicating serogroup B Neisseria meningitidis meningitis. 62
31638913 2019
36
50 Years Ago in TheJournal ofPediatrics: Heparin Therapy in Fulminant Meningococcemia. 62
31439162 2019
37
Chronic meningococcemia: a report of 26 cases and literature review. 62
30341638 2019
38
Renal histological findings in a patient with acute renal injury associated with purpura fulminans: a case report. 62
30222177 2019
39
The rash with maculopapules and fever in children. 62
30981292 2019
40
The rash with maculopapules and fever in adults. 62
30981291 2019
41
Primary Meningococcal Septic Arthritis Case Report and Literature Review of an Unusual Manifestation of Meningococcal Disease. 62
31128585 2019
42
Closing the Brief Case: Meningococcemia Leading to a Diagnosis of Complement Deficiency in a 23-Month-Old. 62
30700563 2019
43
The Brief Case: Meningococcemia Leading to a Diagnosis of Complement Deficiency in a 23-Month-Old. 62
30700562 2019
44
Analysis of social and medical portrait of children with pertussis, meningococcal infectious, scarlet fever and estimation of their assigned pharmacotherapy. 62
31622270 2019
45
First Report of a Disease by Rhazes 10 Centuries Ago. 62
30774840 2019
46
Invasive meningococcal disease epidemiology and characterization of Neisseria meningitidis serogroups, sequence types, and clones; implication for use of meningococcal vaccines. 62
30156954 2019
47
Chronic meningococcemia. 62
30788217 2019
48
The Pathogenic Neisseria Use a Streamlined Set of Peptidoglycan Degradation Proteins for Peptidoglycan Remodeling, Recycling, and Toxic Fragment Release. 62
30766523 2019
49
Meningococcemia: rare but life-threatening. 62
30337290 2018
50
Invasive Meningococcal Disease due to group C N. meningitidis ST11 (cc11): The Tuscany cluster 2015-2016. 62
30172636 2018

Variations for Meningococcemia

Expression for Meningococcemia

Search GEO for disease gene expression data for Meningococcemia.

Pathways for Meningococcemia

Pathways related to Meningococcemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.42 THBD SERPINC1 PROCR F5 CFD
2
Show member pathways
12.04 THBD SERPINC1 F5
3
Show member pathways
11.48 THBD SERPINC1 PROCR F5 CFD

GO Terms for Meningococcemia

Cellular components related to Meningococcemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 SERPINC1 PROCR F5 CFD CCL5 BPI
2 extracellular space GO:0005615 9.44 THBD SERPINC1 PROCR F5 CFD CCL5

Biological processes related to Meningococcemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.56 THBD SERPINC1 PROCR F5
2 lipopolysaccharide-mediated signaling pathway GO:0031663 9.46 CCL5 BPI
3 hemostasis GO:0007599 8.92 THBD SERPINC1 PROCR F5

Sources for Meningococcemia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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