MCID: MNN009
MIFTS: 49

Meningoencephalitis

Categories: Neuronal diseases

Aliases & Classifications for Meningoencephalitis

MalaCards integrated aliases for Meningoencephalitis:

Name: Meningoencephalitis 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10554
ICD10 33 A69.22 G04
MeSH 44 D008590
NCIt 50 C34813
SNOMED-CT 68 7125002
UMLS 73 C0025309

Summaries for Meningoencephalitis

Disease Ontology : 12 A central nervous system disease that involves encephalitis which occurs along with meningitis.

MalaCards based summary : Meningoencephalitis is related to meningitis and acquired immunodeficiency syndrome. An important gene associated with Meningoencephalitis is CARD9 (Caspase Recruitment Domain Family Member 9), and among its related pathways/superpathways are Tuberculosis and C-type lectin receptor signaling pathway. The drugs Fluconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and t cells, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 76 Meningoencephalitis (/mɪ�?nɪ�?ɡo�?�?n�?s�?f�?�?laɪtɪs, -�?nɪnd�?o�?-, -�?n-, -�?k�?-/; from Greek... more...

Related Diseases for Meningoencephalitis

Diseases related to Meningoencephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 354)
# Related Disease Score Top Affiliating Genes
1 meningitis 30.6 ALB IL6 TLR9
2 acquired immunodeficiency syndrome 30.3 ALB B2M IL6
3 parotitis 30.2 ALB CD79A
4 otitis media 30.0 ALB CD79A IL6
5 peritonitis 29.9 ALB B2M IL6
6 human immunodeficiency virus infectious disease 29.7 B2M CCL5 IL6 TLR9
7 toxoplasmosis 29.7 CD40LG CD79A IL6 TLR9
8 viral infectious disease 29.7 CCL5 CD40LG IL6 TLR9
9 syphilis 29.7 B2M CD40LG CD79A
10 pneumonia 29.6 CCL5 CD40LG IL6 TLR9
11 guillain-barre syndrome 29.6 ALB CD79A MBP
12 endometritis 29.5 CHKB IL6 SLC17A5
13 common variable immunodeficiency 29.3 CD40LG CD79A IL6 TLR9
14 systemic lupus erythematosus 29.3 ALB CCL5 CD40LG CD79A IL6 MECP2
15 multiple sclerosis 29.2 CCL5 IL6 MBP TLR9
16 yellow fever 29.2 CCL5 IL6 TLR9
17 inflammatory bowel disease 28.8 ALB CCL5 IL6 TAC1 TLR9
18 asthma 28.7 CCL5 CD40LG IL6 TAC1 TLR9
19 primary amebic meningoencephalitis 12.6
20 lymphocytic choriomeningitis 11.9
21 tick-borne encephalitis 11.3
22 trichinosis 11.3
23 pulmonary alveolar microlithiasis 11.0
24 parenchymatous neurosyphilis 11.0
25 tick infestation 11.0
26 amoebiasis due to free-living amoebae 11.0
27 listeriosis 10.6
28 west nile virus 10.3
29 tinea profunda 10.3 ALB CARD9
30 c1q nephropathy 10.3 CD40LG CD79A
31 immunoglobulin g deficiency 10.3 CD40LG CD79A
32 cryofibrinogenemia 10.3 CD40LG CD79A
33 fournier gangrene 10.3 ALB CD40LG
34 immunodeficiency 43 10.3 ALB B2M
35 heparin-induced thrombocytopenia 10.3 CD40LG CD79A
36 root caries 10.2 ALB CD79A
37 immunoglobulin a deficiency 1 10.2 CD40LG CD79A
38 sporotrichosis 10.2 CD40LG CD79A
39 congenital syphilis 10.2 CD40LG CD79A
40 extramedullary plasmacytoma 10.2 B2M IL6
41 mumps 10.2
42 secondary syphilis 10.2 CD40LG CD79A
43 orthostatic proteinuria 10.2 ALB B2M
44 diffuse glomerulonephritis 10.2 ALB B2M
45 herpes simplex 10.2
46 meningovascular neurosyphilis 10.2 ALB MBP
47 hemorrhagic fever with renal syndrome 10.2 ALB B2M IL6
48 plasma cell neoplasm 10.2 B2M CD79A IL6
49 vasomotor rhinitis 10.2 CD40LG TAC1
50 hydrocephalus 10.2

Graphical network of the top 20 diseases related to Meningoencephalitis:



Diseases related to Meningoencephalitis

Symptoms & Phenotypes for Meningoencephalitis

MGI Mouse Phenotypes related to Meningoencephalitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.11 ALB APP B2M CD40LG CD79A CREBBP
2 homeostasis/metabolism MP:0005376 10.1 ALB APP B2M CARD9 CD40LG CD79A
3 behavior/neurological MP:0005386 10.06 APP CHKB CREBBP IL6 MBP MECP2
4 hematopoietic system MP:0005397 10.02 APP B2M CARD9 CCL5 CD40LG CD79A
5 immune system MP:0005387 9.9 APP B2M CARD9 CCL5 CD40LG CD79A
6 integument MP:0010771 9.5 APP B2M CD40LG CREBBP IL6 MECP2
7 nervous system MP:0003631 9.32 APP B2M CD40LG CD79A CHKB CREBBP

Drugs & Therapeutics for Meningoencephalitis

Drugs for Meningoencephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved, Investigational Phase 3,Phase 2,Not Applicable 86386-73-4 3365
2
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Not Applicable 22916-47-8 4189
3
Sertraline Approved Phase 3 79617-96-2 68617
4 Immunoglobulins Phase 3,Phase 1,Phase 2
5 Antibodies Phase 3,Phase 1,Phase 2
6 Immunologic Factors Phase 3,Phase 2,Phase 1
7 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 2,Not Applicable
8 Cytochrome P-450 CYP2C19 Inhibitors Phase 3,Phase 2,Not Applicable
9 Steroid Synthesis Inhibitors Phase 3,Phase 2,Not Applicable
10 Cytochrome P-450 CYP2C9 Inhibitors Phase 3,Phase 2,Not Applicable
11 Hormones Phase 3,Phase 2,Not Applicable
12 Anti-Infective Agents Phase 3,Phase 2,Not Applicable
13 Hormone Antagonists Phase 3,Phase 2,Not Applicable
14 Antifungal Agents Phase 3,Phase 2,Not Applicable
15 Neurotransmitter Agents Phase 3
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
17 Immunoglobulins, Intravenous Phase 3
18 gamma-Globulins Phase 3
19 Rho(D) Immune Globulin Phase 3
20 Neurotransmitter Uptake Inhibitors Phase 3
21 Psychotropic Drugs Phase 3
22 Serotonin Agents Phase 3
23 Serotonin Uptake Inhibitors Phase 3
24 Antidepressive Agents Phase 3
25
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
26
Aluminum hydroxide Approved, Investigational Phase 2 21645-51-2
27
Aluminum sulfate Approved Phase 2 10043-01-3
28
Tamoxifen Approved Phase 2 10540-29-1 2733526
29
Amphotericin B Approved, Investigational Phase 2 1397-89-3 5280965 14956
30 Antibodies, Monoclonal Phase 1, Phase 2
31 Vaccines Phase 2,Phase 1
32 Adjuvants, Immunologic Phase 2
33 Gastrointestinal Agents Phase 2
34 Anti-Ulcer Agents Phase 2
35 Antacids Phase 2
36 Estrogen Antagonists Phase 2
37 Anti-Bacterial Agents Phase 2
38 Liposomal amphotericin B Phase 2
39 Antiprotozoal Agents Phase 2
40 Cytochrome P-450 CYP3A Inhibitors Phase 2
41 Estrogens Phase 2
42 Selective Estrogen Receptor Modulators Phase 2
43 Estrogen Receptor Modulators Phase 2
44 Antineoplastic Agents, Hormonal Phase 2
45 Bone Density Conservation Agents Phase 2
46 Antiparasitic Agents Phase 2
47 Estrogen Receptor Antagonists Phase 2
48
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
49
Acyclovir Approved 59277-89-3 2022
50
Ceftriaxone Approved 73384-59-5 5479530 5361919

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Investigating the Role of Early Intravenous Immunoglobulin Treatment for Children With Encephalitis Active, not recruiting NCT02308982 Phase 3 Immunoglobulins, Intravenous (Privigen);Placebo
2 Cryptococcal Antigen Screening Plus Sertraline Terminated NCT03002012 Phase 3 Sertraline;Placebo Oral Tablet;Fluconazole
3 Phase Ib Study of SC Milatuzumab in SLE Unknown status NCT01845740 Phase 1, Phase 2 milatuzumab;Placebo
4 A Phase II Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants Completed NCT01399853 Phase 2
5 A Booster Dose of Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children Completed NCT01734408 Phase 2
6 Treatment With Tamoxifen in Cryptococcal Meningitis Recruiting NCT03112031 Phase 2 Tamoxifen;Amphotericin B;Fluconazole
7 A Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants Completed NCT01313715 Phase 1
8 A Clinical Trial for Inactivated Vaccine(Vero Cell) Against EV71 in Chinese Healthy Young Adults and Children Completed NCT01267903 Phase 1
9 Pharmacokinetic Study in Cerebral Spinal Fluid After a Single Dose of AVI-4020 Completed NCT00387283 Phase 1 AVI-4020 Injection
10 Study Assessing Tolerability and Safety of AFFITOPE® PD03A in Patients With Early Parkinson's Disease Completed NCT02267434 Phase 1
11 Study Assessing Safety and Therapeutic Activity of AFFITOPE® PD01A and PD03A in Patients With Early MSA Completed NCT02270489 Phase 1
12 An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
13 Etiology of Orphan Community-based Meningitis and Meningo-encephalitis. Unknown status NCT02868593 Not Applicable
14 Rijavithi Viral and Mycobacterium PCR Arrays in CNS Infection Study Completed NCT00807378
15 Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus Completed NCT00858884 Not Applicable
16 Magnetic Resonance Spectroscopy, Perfusion, and Diffusion Tensor Imaging in Neuropsychiatric Lupus Completed NCT00730002 Not Applicable
17 Magnetic Resonance Spectroscopy, Perfusion and Diffusion Tensor Imaging in Neuropsychiatric Lupus Completed NCT00723671 Not Applicable
18 Aseptic Meningoencephalitis in Slovenia Recruiting NCT02328469 symptomatic therapy;Ceftriaxone or Doxycycline;Acyclovir
19 Driving Reduced AIDS-associated Meningo-encephalitis Mortality Recruiting NCT03226379
20 EURopean Study on Encephalitis in Intensive CAre Recruiting NCT03144570
21 Research for Angiostrongylus Cantonensis and Costaricensis in French West Indies and French Guiana Recruiting NCT03378882
22 Identification and Quantification of HIV CNS Latency Biomarkers Recruiting NCT02989285
23 Development of a Novel Glutamate Receptor Ligand for PET Scans in Neuropsychiatric Systemic Lupus Erythematosus Recruiting NCT02456168
24 Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients Active, not recruiting NCT02207647
25 Pre-Antiretroviral Therapy (ART) Cryptococcal Antigen Screening in AIDS Active, not recruiting NCT02624453 Not Applicable Fluconazole;Antiretroviral therapy

Search NIH Clinical Center for Meningoencephalitis

Cochrane evidence based reviews: meningoencephalitis

Genetic Tests for Meningoencephalitis

Anatomical Context for Meningoencephalitis

MalaCards organs/tissues related to Meningoencephalitis:

41
Brain, Pituitary, T Cells, B Cells, Kidney, Liver, Skin

Publications for Meningoencephalitis

Articles related to Meningoencephalitis:

(show top 50) (show all 1138)
# Title Authors Year
1
Neospora caninum and Ehrlichia canis co-infection in a dog with meningoencephalitis. ( 29406569 )
2018
2
Pharmacodynamics of Flubendazole for Cryptococcal Meningoencephalitis: Repurposing and Reformulation of an Anti-Parasitic Agent for a Neglected Fungal Disease. ( 29311092 )
2018
3
Streptococcus agalactiae meningoencephalitis associated with gastroesophageal reflux disease and chronic proton pump inhibitors use, in a 9A month-old infant: a case report. ( 29390957 )
2018
4
Influenza B-related meningoencephalitis in adults. ( 29930187 )
2018
5
Cerebrospinal fluid changes in cattle with rabies or with BoHV-5 meningoencephalitis and its correlation with the severity of CNS inflammatory process. ( 29684815 )
2018
6
Sonographic Diagnosis of Meningoencephalitis in Newborns and Infants. ( 29534259 )
2018
7
Chronic meningoencephalitis caused by Echo virusA 6 in aA patient with common variable immunodeficiency : Successful treatment with pleconaril. ( 29116409 )
2018
8
Estimation of Undiagnosed Naegleria fowleri Primary Amebic Meningoencephalitis, United States<sup>1</sup>. ( 29260676 )
2018
9
Systemic Staphylococcus pseudintermedius infection in an arctic fox (Vulpes lagopus) with severe multifocal suppurative meningoencephalitis and nephritis. ( 29887579 )
2018
10
A four-year survey (2011-2014) of West Nile virus infection in humans, mosquitoes and birds, including the 2012 meningoencephalitis outbreak in Tunisia. ( 29535295 )
2018
11
Rheumatoid disease: an unusual cause of relapsing meningoencephalitis. ( 29330273 )
2018
12
Clinical presentation and magnetic resonance imaging findings in 11 dogs with eosinophilic meningoencephalitis of unknown aetiology. ( 29603737 )
2018
13
Lyme Meningoencephalitis Masquerading as Normal Pressure Hydrocephalus. ( 29872598 )
2018
14
Nurse's guide to primary amebic meningoencephalitis. ( 29561369 )
2018
15
An uncommon complication of <i>Listeria monocytogenes</i> infection: Polyradiculoneuritis following Listeria meningoencephalitis. ( 29942763 )
2018
16
Emergency Foramen Magnum Decompression for Tonsillar Herniation Secondary to Meningoencephalitis. ( 29681828 )
2018
17
Primary Amebic Meningoencephalitis Associated With Rafting on an Artificial Whitewater River: Case Report and Environmental Investigation. ( 29401275 )
2018
18
Parasitic and zoonotic meningoencephalitis in humans and equids: Current knowledge and the role of <i>Halicephalobus gingivalis</i>. ( 29774297 )
2018
19
Identification and molecular typing of Naegleria fowleri from a patient with primary amebic meningoencephalitis in China. ( 29751112 )
2018
20
Pleocytosis in a patient with relapsing polychondritis accompanied by meningoencephalitis: a case report. ( 29699514 )
2018
21
Acute Disseminated Encephalomyelitis After Herpes Simplex Virus Meningoencephalitis in Adult. ( 29581077 )
2018
22
Cryptococcal meningoencephalitis in patients with mantle cell lymphoma on ibrutinib. ( 29910833 )
2018
23
Co-infection ZIKV and HSV-1 associated with meningoencephalitis: Case report and literature review. ( 29703710 )
2018
24
Clinical Images: A Rare Case of Cryptococcal Meningoencephalitis in an Immunocompetent Patient. ( 29559862 )
2018
25
Mortality from Listeria monocytogenes meningoencephalitis following escalation to alemtuzumab therapy for relapsing-remitting Multiple Sclerosis. ( 29885597 )
2018
26
Report of two cases of tocilizumab induced recurrent meningitis or meningoencephalitis. ( 29366968 )
2018
27
<i>Mycoplasma pneumoniae</i> infection presenting as stroke and meningoencephalitis with aortic and subclavian aneurysms without pulmonary involvement. ( 29326371 )
2018
28
Meningoencephalitis caused by Lactobacillus plantarum - case report. ( 29813007 )
2018
29
Jamestown Canyon virus meningoencephalitis mimicking migraine with aura in a resident of Manitoba. ( 29507158 )
2018
30
Diabetes insipidus secondary to tuberculous meningoencephalitis with hypothalamic involvement extending to the hypophysis: a case report. ( 30517545 )
2018
31
Ehrlichiosis presenting as severe sepsis and meningoencephalitis in an immunocompetent adult. ( 30425837 )
2018
32
A Fatal Case of Atypical Disseminated Herpes Zoster in a Patient with Meningoencephalitis and Seizures Associated with Steroid Immunosuppression. ( 30270342 )
2018
33
Three children of meningoencephalitis with Kikuchi necrotizing lymphadenitis. ( 29050838 )
2018
34
Lymphocytic choriomeningitis virus meningoencephalitis in a renal transplant recipient following exposure to mice. ( 30325104 )
2018
35
Serological prevalence of toxoplasmosis and neosporosis in dogs diagnosed with suspected meningoencephalitis in the UK. ( 30371939 )
2018
36
Magnetic resonance imaging features of gelatinous pseudocysts in cryptococcal meningoencephalitis. ( 30374842 )
2018
37
Vibrio vulnificus meningoencephalitis in a patient with thalassemia and a splenectomy. ( 30397825 )
2018
38
Relapsing Polychondritis with Meningoencephalitis Refractory to Immunosuppressant Therapy. ( 30402308 )
2018
39
Acute enteroviral meningoencephalitis as unusual cause of diplopia in pregnancy and puerperium. ( 30441959 )
2018
40
Cryptococcal meningoencephalitis in an elderly immunocompetent non-HIV-infected patient. ( 30472030 )
2018
41
Human Chronic Necrotizing Granulomatous Meningoencephalitis: A Novel Case Report. ( 30483106 )
2018
42
Phenotypic screens reveal posaconazole as rapidly cidal combination partner for treatment of Primary Amoebic Meningoencephalitis. ( 30358879 )
2018
43
Immunohistochemical studies on meningoencephalitis in feline infectious peritonitis (FIP). ( 30333381 )
2018
44
Atypical Anti-MOG syndrome with aseptic meningoencephalitis and pseudotumor cerebri-like presentations. ( 30300850 )
2018
45
A Predominant Clonal Thromboembolic Meningoencephalitis Group of Histophilus somni Assigned by Major Outer Membrane Protein Gene Sequencing and Pulsed-Field Gel Electrophoresis. ( 30283793 )
2018
46
An Autopsy Case of Edwardsiella tarda Meningoencephalitis. ( 30283323 )
2018
47
Closing the Brief Case: A 10-Year-Old Girl with Meningoencephalitis. ( 30254111 )
2018
48
The Brief Case: A 10-Year-Old Girl with Meningoencephalitis. ( 30254110 )
2018
49
Clinical case report on treatment of Listeria monocytogenes meningoencephalitis: Intrathecal injection. ( 30214776 )
2018
50
Rapid Therapeutic Response of Eosinophilic Meningoencephalitis in a Toddler With Baylisascaris procyonis Infection. ( 30193023 )
2018

Variations for Meningoencephalitis

Expression for Meningoencephalitis

Search GEO for disease gene expression data for Meningoencephalitis.

Pathways for Meningoencephalitis

Pathways related to Meningoencephalitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.88 CARD9 CREBBP IL6 TLR9
2
Show member pathways
11.69 CARD9 CREBBP IL6 TLR9
3 11.61 B2M CARD9 CCL5 CD40LG CD79A TLR9
4 11.47 CREBBP IL6 MECP2 TAC1
5 11.34 CCL5 IL6 MECP2
6 11.12 CD40LG IL6 TLR9

GO Terms for Meningoencephalitis

Cellular components related to Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 ALB APP B2M CCL5 CD40LG IL6
2 endoplasmic reticulum lumen GO:0005788 9.26 ALB APP B2M IL6
3 extracellular space GO:0005615 9.23 ALB APP B2M CCL5 CD40LG IL6

Biological processes related to Meningoencephalitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 neuron projection development GO:0031175 9.72 APP IL6 MECP2
2 cellular protein metabolic process GO:0044267 9.71 ALB APP B2M IL6
3 positive regulation of JNK cascade GO:0046330 9.65 APP CARD9 TLR9
4 inflammatory response GO:0006954 9.55 CCL5 CD40LG IL6 TAC1 TLR9
5 positive regulation of chemokine production GO:0032722 9.54 IL6 TLR9
6 positive regulation of T cell proliferation GO:0042102 9.54 CCL5 CD40LG IL6
7 positive regulation of T cell migration GO:2000406 9.52 APP CCL5
8 positive regulation of acute inflammatory response GO:0002675 9.51 IL6 TAC1
9 positive regulation of interleukin-6 production GO:0032755 9.5 CARD9 IL6 TLR9
10 response to molecule of bacterial origin GO:0002237 9.49 B2M TLR9
11 tachykinin receptor signaling pathway GO:0007217 9.46 TAC1 TACR3
12 response to peptidoglycan GO:0032494 9.43 CARD9 IL6
13 tumor necrosis factor production GO:0032640 9.26 APP TLR9
14 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.26 APP CD40LG IL6 TLR9
15 immune response GO:0006955 9.1 B2M CCL5 CD40LG IL6 MBP TLR9

Molecular functions related to Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 siRNA binding GO:0035197 8.62 MECP2 TLR9

Sources for Meningoencephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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