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MCID: MNN009
MIFTS: 49

Meningoencephalitis

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Meningoencephalitis

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MalaCards integrated aliases for Meningoencephalitis:

Name: Meningoencephalitis 12 54 43 15 17 71

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:10554
MeSH 43 D008590
NCIt 49 C34813
SNOMED-CT 67 7125002
ICD10 32 A69.22 G04
UMLS 71 C0025309
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Summaries for Meningoencephalitis

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Disease Ontology : 12 A central nervous system disease that involves encephalitis which occurs along with meningitis.

MalaCards based summary : Meningoencephalitis is related to listeriosis and meningitis. An important gene associated with Meningoencephalitis is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Immunologic Factors and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and pituitary, and related phenotypes are cellular and hematopoietic system

Wikipedia : 74 Meningoencephalitis (/m??n??go??n?s?f?'la?t?s, -?n?nd?o?-, -?n-, -?k?-/; from Greek ?????? meninx,... more...

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Related Diseases for Meningoencephalitis

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Diseases related to Meningoencephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 931)
# Related Disease Score Top Affiliating Genes
1 listeriosis 31.8 IL6 CD8A CD4
2 meningitis 31.5 IL6 GDNF CD40LG CCL5 ALB
3 toxoplasmosis 31.5 IL6 CD79A CD40LG
4 chlamydia 31.2 IL6 CD79A CD40LG
5 parotitis 31.1 CD79A CD40LG CD4 ALB
6 otitis media 31.0 IL6 CD79A CD40LG ALB
7 brain edema 31.0 IL6 CLDN5 ALB
8 myelitis 31.0 MBP IL6 CD40LG
9 hydrocephalus 31.0 NGF MBP GDNF BDNF APP
10 herpes zoster 30.9 CD8A CD40LG CD4
11 chickenpox 30.9 IL6 CD8A CD40LG CD4 ALB
12 viral meningitis 30.9 IL6 CD40LG CCL5 B2M
13 q fever 30.8 IL6 CD40LG CCL5
14 papilledema 30.8 CD40LG CD4 ALB
15 optic neuritis 30.8 MBP GDNF BDNF
16 coccidioidomycosis 30.8 CD40LG CD4 CARD9
17 chlamydia pneumonia 30.8 IL6 CD40LG CD4
18 exanthem 30.8 IL6 CD8A CD40LG CD4 ALB
19 typhoid fever 30.8 IL6 CD40LG ALB
20 purpura 30.8 IL6 CD79A CD40LG
21 rabies 30.7 CD40LG CCL5 ALB
22 guillain-barre syndrome 30.7 MBP CD79A CD40LG ALB
23 pleural empyema 30.7 CD79A CD40LG CD4 ALB
24 cranial nerve palsy 30.7 CD40LG CD4 ALB
25 diarrhea 30.7 TAC1 IL6 CD40LG ALB
26 cytomegalovirus infection 30.7 IL6 CCL5 B2M
27 endophthalmitis 30.6 IL6 CD4 CARD9 ALB
28 neuritis 30.6 MBP IL6 GDNF CCL5 BDNF
29 cysticercosis 30.6 IL6 CD40LG CD4
30 chronic graft versus host disease 30.6 CD79A CD4 ALB
31 immune deficiency disease 30.5 IL6 CD79A CD40LG CD4 CCL5 B2M
32 autoimmune disease 30.5 MBP IL6 CD79A CD40LG CCL5
33 peritonitis 30.5 IL6 CXCL2 CCL5 B2M ALB
34 iridocyclitis 30.5 IL6 CD40LG CD4
35 respiratory failure 30.5 TAC1 IL6 CD4 CCL5 ALB
36 poliomyelitis 30.5 CD8A CD40LG CD4
37 epidemic typhus 30.5 CD8A CD40LG CD4 CCL5
38 asymptomatic neurosyphilis 30.4 CD40LG CD4
39 neuromyelitis optica 30.4 MBP IL6 CD40LG
40 aspiration pneumonia 30.4 TAC1 IL6 CD40LG ALB
41 acquired immunodeficiency syndrome 30.4 MBP IL6 CD79A CD40LG CD4 B2M
42 strongyloidiasis 30.4 CD79A CD40LG CD4
43 traumatic brain injury 30.4 MBP IL6 BDNF
44 facial paralysis 30.4 CD8A CD40LG CD4 ALB
45 kawasaki disease 30.4 IL6 CD40LG CD4 ALB
46 rhinitis 30.3 NGF IL6 CCL5 ALB
47 encephalomalacia 30.3 MBP IL6 BDNF
48 decubitus ulcer 30.3 NGF IL6 ALB
49 bacterial infectious disease 30.3 IL6 CXCL2 CD8A CD40LG CD4
50 normal pressure hydrocephalus 30.3 NGF GDNF BDNF APP

Graphical network of the top 20 diseases related to Meningoencephalitis:



Diseases related to Meningoencephalitis
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Symptoms & Phenotypes for Meningoencephalitis

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MGI Mouse Phenotypes related to Meningoencephalitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.23 ALB APP B2M BDNF CD4 CD40LG
2 hematopoietic system MP:0005397 10.22 APP B2M C5AR1 CARD9 CCL5 CD4
3 cardiovascular system MP:0005385 10.18 ALB APP B2M CD40LG CLDN5 CXCL2
4 homeostasis/metabolism MP:0005376 10.18 ALB APP B2M BDNF C5AR1 CARD9
5 immune system MP:0005387 10.17 ALB APP B2M C5AR1 CARD9 CCL5
6 endocrine/exocrine gland MP:0005379 10.13 ALB B2M BDNF CD4 CD40LG CD8A
7 mortality/aging MP:0010768 10.03 ALB APP B2M BDNF C5AR1 CD4
8 integument MP:0010771 9.91 APP B2M BDNF CD4 CD40LG CD8A
9 nervous system MP:0003631 9.73 APP B2M BDNF CD4 CD40LG CD79A
10 normal MP:0002873 9.28 ALB APP BDNF CD4 CD79A CD8A
Sources

Drugs & Therapeutics for Meningoencephalitis

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Drugs for Meningoencephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 3
2 Immunoglobulins Phase 3
3 Antibodies Phase 3
4 Rho(D) Immune Globulin Phase 3
5 Immunoglobulins, Intravenous Phase 3
6 gamma-Globulins Phase 3
7
Aluminum hydroxide Approved, Investigational Phase 2 21645-51-2
8
Aluminum sulfate Approved Phase 2 10043-01-3
9
Tamoxifen Approved Phase 2 10540-29-1 2733526
10
Amphotericin B Approved, Investigational Phase 2 1397-89-3 14956 5280965
11
Valganciclovir Approved, Investigational Phase 2 175865-60-8 64147
12 Pleconaril Investigational Phase 2 153168-05-9
13 Anti-Bacterial Agents Phase 2
14 Antiparasitic Agents Phase 2
15 Antiviral Agents Phase 2
16 Antiprotozoal Agents Phase 2
17 Anti-Infective Agents Phase 2
18 Vaccines Phase 2
19 Gastrointestinal Agents Phase 2
20 Adjuvants, Immunologic Phase 2
21 Anti-Ulcer Agents Phase 2
22 Antacids Phase 2
23 Estrogens Phase 2
24 Cytochrome P-450 CYP3A Inhibitors Phase 2
25 Selective Estrogen Receptor Modulators Phase 2
26 Liposomal amphotericin B Phase 2
27 Estrogen Antagonists Phase 2
28 Antineoplastic Agents, Hormonal Phase 2
29 Estrogen Receptor Antagonists Phase 2
30 Estrogen Receptor Modulators Phase 2
31
Lamivudine Approved, Investigational 134678-17-4 60825
32
Nevirapine Approved 129618-40-2 4463
33
Stavudine Approved, Investigational 3056-17-5 18283
34
Ceftriaxone Approved 73384-59-5 5479530 5361919
35
Acyclovir Approved 59277-89-3 2022
36
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
37
Fluconazole Approved, Investigational 86386-73-4 3365
38
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
39 Cytochrome P-450 CYP3A Inducers
40 Reverse Transcriptase Inhibitors
41 Antimetabolites
42 Anti-HIV Agents
43 Antipyretics
44 Antibiotics, Antitubercular
45 Antimalarials
46 dipyrone
47 Antiemetics
48 Anti-Retroviral Agents
49 Cytochrome P-450 Enzyme Inhibitors
50 Hormone Antagonists

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 A Phase III Multi-centre Randomised, Double Blind, Placebo Controlled Trial to Assess the Role of Intravenous Immunoglobulin in the Management of Children With Encephalitis Active, not recruiting NCT02308982 Phase 3 Immunoglobulins, Intravenous (Privigen);Placebo
2 A Phase II Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants Completed NCT01399853 Phase 2
3 A Booster Dose of Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children Completed NCT01734408 Phase 2
4 A Randomized Trial of Tamoxifen Combined With Amphotericin B and Fluconazole for Cryptococcal Meningitis Completed NCT03112031 Phase 2 Tamoxifen;Amphotericin B;Fluconazole
5 Double Blinded Placebo Controlled Study to Assess Clinical and Antiviral Activity of Valganciclovir (VAL) in Solid Organ Transplant Donors to Reduce Viral Transmission From Donor to Recipient Completed NCT01329185 Phase 2 Valganciclovir;Placebo
6 A Double-Blind, Placebo-Controlled, Virologic Efficacy Trial of Pleconaril in the Treatment of Neonates With Enteroviral Sepsis Syndrome Completed NCT00031512 Phase 2 Placebo;Pleconaril (VP63843)
7 A Randomized Double Blind Placebo Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin (IVIG) in Children With Japanese Encephalitis in Nepal Completed NCT01856205 Phase 2 Intravenous immunoglobulin [ImmunoRelâ„¢ (batch 20081217)]
8 Pharmacokinetic Study of AVI-4020 in Cerebral Spinal Fluid Among Healthy Adult Males Following Intravenous Administration Completed NCT00387283 Phase 1 AVI-4020 Injection
9 A Phase Ib Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants Completed NCT01313715 Phase 1
10 A Phase Ia Clinical Trial for Inactivated Vaccine(Vero Cell) Against EV71 in Chinese Healthy Young Adults and Children Completed NCT01267903 Phase 1
11 An Exploratory Study of the Safety, Tolerability, Pharmacokinetics and Potential Effectiveness of AVI-4020 Injection in Patients Presenting With Presumptive Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
12 Etiology of Orphan Community-based Meningitis and Meningo-encephalitis. Unknown status NCT02868593
13 sCD163 & CD19 as Candidate Biomarkers in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) - A Study of sCD163 in the Cerebrospinal Fluid Unknown status NCT02271724
14 sCD163 as a Potential Biomarker in Guillain- Barré Syndrome Unknown status NCT02582853
15 Cerebrospinal Fluid Polymerase Chain Reaction Arrays for Central Nervous System Neurotropic Viral Infection and Mycobacterium Infection Study Completed NCT00807378
16 Randomized Control Trial of Early vs Delayed ART in the Treatment of Cryptococcal Meningitis. Completed NCT00830856 Fluconazole;Fixed dose - Stavudine, lamivudine and Nevirapine;Fixed dose - Stavudine, Lamivudine, Nevirapine
17 Inflammation in Amyotrophic Lateral Sclerosis - a Study of Soluble Cluster of Differentiation 163 in the Cerebrospinal Fluid Completed NCT02325375
18 Prospective Study of the Etiology, Pathogenesis, Clinical Picture and Outcome of Aseptic Meningitis in Slovenia Recruiting NCT02328469 symptomatic therapy;Ceftriaxone or Doxycycline;Acyclovir
19 Application of Next Generation Sequencing Technique in Pediatric Bacterial Meningitis Recruiting NCT03953638
20 Research for Angiostrongylus Cantonensis and Costaricensis in French West Indies and French Guiana: a Clinical and Environmental Study Recruiting NCT03378882
21 The Identification and Quantification of HIV CNS Latency Biomarkers Recruiting NCT02989285
22 Fever After Tick Bite (FATB) Study; Determining the Etiology of Tick-Borne Human Infections in Northern Europe Recruiting NCT03932448
23 Integrating the Diagnosis and Management of HIV-associated Central Nervous System (CNS) Infections Into Routine Health Services in Low and Middle Income Countries (LMICs) Recruiting NCT03226379
24 Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients Active, not recruiting NCT02207647
25 Implementation and Evaluation of a Screening Strategy to Reduce Morbidity and Mortality Due to Cryptoccocal Meningo-encephalitis in ART Naive AIDS Patients With <100 CD4 Count at the Day Hospital of the Yaounde Central Hospital, Cameroon Active, not recruiting NCT02624453 Fluconazole;Antiretroviral therapy

Search NIH Clinical Center for Meningoencephalitis

Cochrane evidence based reviews: meningoencephalitis

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Genetic Tests for Meningoencephalitis

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Anatomical Context for Meningoencephalitis

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MalaCards organs/tissues related to Meningoencephalitis:

40
Brain, T Cells, Pituitary, Lung, Kidney, B Cells, Liver
Sources

Publications for Meningoencephalitis

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Articles related to Meningoencephalitis:

(show top 50) (show all 6935)
# Title Authors PMID Year
1
HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele. 54 61
19675171 2009
2
Abeta-induced meningoencephalitis is IFN-gamma-dependent and is associated with T cell-dependent clearance of Abeta in a mouse model of Alzheimer's disease. 54 61
16549802 2006
3
Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease. 54 61
14997933 2004
4
Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice. 54 61
12805119 2003
5
No evidence for elevated numbers of mononuclear cells expressing MCP-1 and RANTES mRNA in blood and CSF in multiple sclerosis. 54 61
9846826 1998
6
A substance P antagonist, RP-67,580, ameliorates a mouse meningoencephalitic response to Trypanosoma brucei brucei. 54 61
9108123 1997
7
Antimyelin basic protein and antimyelin antibody-producing cells in multiple sclerosis. 54 61
1690527 1990
8
Acute cerebellar ataxia: a rare Toscana Virus (TOSV) meningoencephalitis complication. 61
31554442 2020
9
Borrelia prevalence and species distribution in ticks removed from humans in Germany, 2013-2017. 61
31987819 2020
10
Naegleria fowleri: Sources of infection, pathophysiology, diagnosis, and management; a review. 61
31612525 2020
11
Listeria monocytogenes septicemia and meningoencephalitis associated with relapsed and refractory follicular lymphoma. 61
32033853 2020
12
Cryptococcal antigenemia prevalence and clinical data in HIV-infected patients from the reference centre at INI-FIOCRUZ, Rio de Janeiro, Southeast of Brazil. 61
31715053 2020
13
Biphasic evolution of varicella-zoster virus meningoencephalitis : Diagnostic challenges. 61
31767157 2020
14
Initial Narrow- or Broad-spectrum Treatment for Meningoencephalitis. 61
31534085 2020
15
Reply to "Initial Narrow- or Broad-spectrum Treatment for Meningoencephalitis". 61
31534095 2020
16
First molecular characterization of Sarcocystis neurona causing meningoencephalitis in a domestic cat in Brazil. 61
31901995 2020
17
The eye is the window to the diagnosis: tuberculous meningoencephalitis with choroidal tubercle. 61
31427384 2020
18
Distinctive features of bovine alphaherpesvirus types 1 and 5 and the virus-host interactions that might influence clinical outcomes. 61
31845150 2020
19
Serologic evidence of widespread Toscana virus infection in Bulgaria. 61
31401037 2020
20
Cladophialophora encephalitis in an alpaca. 61
32020931 2020
21
Human pegivirus in brain tissue of a patient with encephalitis. 61
31753519 2020
22
A 9-month retrospective evaluation of the aetiology and management of patients presenting with encephalitis/meningoencephalitis at a South London hospital. 61
32019624 2020
23
Pituitary apoplexy mimicking meningoencephalitis: case report and scoping study. 61
31976773 2020
24
Isotonic versus hypotonic saline as maintenance intravenous fluid therapy in children under 5 years of age admitted to general paediatric wards: a randomised controlled trial. 61
31138063 2020
25
Comparison of antibiotic and acyclovir usage before and after the implementation of an on-site FilmArray meningitis/encephalitis panel in an academic tertiary pediatric hospital: a retrospective observational study. 61
32020860 2020
26
Effect of subinhibitory concentrations of ampicillin on Listeria monocytogenes. 61
31027868 2020
27
Impact of the implementation of a rapid meningitis/encephalitis multiplex polymerase chain reaction panel on IV acyclovir duration: multicenter, retrospective cohort of adult and pediatric patients. 61
31761479 2020
28
Cryptococcosis. 61
32000285 2020
29
Scrub typhus with meningoencephalitis - four cases. 61
31979815 2020
30
Fowlerstefin, a cysteine protease inhibitor of Naegleria fowleri, induces inflammatory responses in BV-2 microglial cells in vitro. 61
31996242 2020
31
Is Naegleria fowleri an Emerging Parasite? 61
31744676 2020
32
Isolation of Naegleria spp. from a Brazilian Water Source. 61
32024031 2020
33
Aryl Quinazolinone Derivatives as Novel Therapeutic Agents against Brain-Eating Amoebae. 61
31961126 2020
34
Clinical, laboratory and immune aspects of Zika virus-associated encephalitis in children. 61
31678190 2020
35
Evaluation of cerebrospinal fluid CXCL13 concentrations and lymphocyte subsets in tick-borne encephalitis. 61
31978584 2020
36
Identification, Genetic Analysis, and Pathogenicity of Classical Swine H1N1 and Human-Swine Reassortant H1N1 Influenza Viruses from Pigs in China. 61
31906591 2020
37
A case of primary amebic meningoencephalitis caused by Naegleria fowleri in Bangladesh. 61
31734864 2020
38
First Case of Idiopathic Eosinophilic Meningoencephalitis in a Sheep. 61
31955804 2020
39
Multifocal cryptococcal disease in an HIV-infected patient: from diagnostic pursuit to management peculiarities. 61
31937629 2020
40
Symptomatic Narcolepsy/Cataplexy in a Dog with Brainstem Meningoencephalitis of Unknown Origin. 61
31961221 2020
41
Effectiveness of Intravenous Isoniazid and Ethambutol Administration in Patients with Tuberculosis Meningoencephalitis and HIV Infection. 61
31905437 2020
42
Investigation of astrovirus and bornavirus in the cerebrospinal fluid of dogs clinically diagnosed with meningoencephalitis of unknown etiology. 61
31785029 2020
43
Postencephalitic epilepsy in dogs with meningoencephalitis of unknown origin: Clinical features, risk factors, and long-term outcome. 61
31990104 2020
44
Utility of FilmArrayⓇ ME panel for prompt Neisseria meningitidis detection in non-cerebrospinal fluid samples- A case report. 61
31669378 2020
45
Cryptococcus neoformans var grubii meningoencephalitis in a patient on fingolimod for relapsing-remitting multiple sclerosis: Case report and review of published cases. 61
31986367 2020
46
Epidemiological characteristics of cryptococcal meningoencephalitis associated with Cryptococcus neoformans var. grubii from HIV-infected patients in Madagascar: A cross-sectional study. 61
31929533 2020
47
Neuropathology and diagnostic features of rabies in a litter of piglets, with a brief review of the literature. 61
31916501 2020
48
Autoimmune glial fibrillary acidic protein astrocytopathy resulting in treatment-refractory flaccid paralysis. 61
31927153 2020
49
Extensive subpial cortical demyelination is specific to multiple sclerosis. 61
31916298 2020
50
Molecular detection of free-living amoebae from Namhangang (southern Han River) in Korea. 61
31942007 2020
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Variations for Meningoencephalitis

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Expression for Meningoencephalitis

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Search GEO for disease gene expression data for Meningoencephalitis.
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Pathways for Meningoencephalitis

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Pathways related to Meningoencephalitis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.83 IL6 GDNF CXCL2 CD8A CD79A CD40LG
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.25 IL6 GDNF CXCL2 CD40LG CD4 CCL5
3
PAK Pathway 63
Show member pathways
 13.16 NGF IL6 CXCL2 CD40LG CD4 CCL5
4
Allograft rejection 1 36
Show member pathways
 12.54 IL6 GDNF CD8A CD40LG CD4 B2M
5
NF-kappaB Signaling 4
12.15 CD8A CD79A CD40LG CCL5 CARD9 B2M
6
NOD-like receptor signaling pathway 36
12.07 IL6 CXCL2 CCL5 CARD9
7
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.99 TAC1 NGF IL6 BDNF
8
Cell adhesion molecules (CAMs) 36
11.9 CLDN5 CD8A CD40LG CD4
9
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.73 IL6 CD8A CD79A CD4
10
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.66 NGF GDNF BDNF
11
Dendritic Cells Developmental Lineage Pathway 64
11.62 IL6 CD8A CD4
12
Microglia Activation During Neuroinflammation: Microglia Polarization 64
11.59 IL6 CCL5 BDNF
13
p75(NTR)-mediated signaling 1
Show member pathways
 11.55 NGF BDNF APP
14
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.51 IL6 CXCL2 CD40LG
15
Lung fibrosis 1
11.5 IL6 CXCL2 CCL5
16
Spinal Cord Injury 1
11.43 MBP IL6 GDNF CXCL2 BDNF
17
Interleukin-10 signaling 65
11.36 IL6 CXCL2 CCL5
18
Cytokines and Inflammatory Response 1
10.9 IL6 CXCL2 CD4
19
G-protein signaling_Rap2B regulation pathway 22
10.78 NGF IL6 CXCL2 CD40LG CCL5 BDNF
20
Primary immunodeficiency 36
10.5 CD8A CD79A CD40LG CD4
Sources

GO Terms for Meningoencephalitis

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Cellular components related to Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.73 MBP CD40LG CD4 C5AR1 B2M APP
2 extracellular region GO:0005576 9.73 TAC1 NGF IL6 GDNF CXCL2 CD8A
3 endoplasmic reticulum lumen GO:0005788 9.55 IL6 CD4 B2M APP ALB
4 extracellular space GO:0005615 9.36 TAC1 NGF IL6 GDNF CXCL2 CD40LG

Biological processes related to Meningoencephalitis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.09 TACR3 IL6 GDNF CXCL2 CD40LG CD4
2 cellular protein metabolic process GO:0044267 9.85 IL6 B2M APP ALB
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.83 CD4 CCL5 C5AR1 APP
4 neutrophil chemotaxis GO:0030593 9.74 CXCL2 CCL5 C5AR1
5 inflammatory response GO:0006954 9.73 TAC1 IL6 CXCL2 CD40LG CCL5 C5AR1
6 negative regulation of neuron apoptotic process GO:0043524 9.71 NGF GDNF C5AR1 BDNF
7 positive regulation of protein binding GO:0032092 9.69 CLDN5 B2M APP
8 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.67 NGF CD8A CD4 BDNF
9 amyloid fibril formation GO:1990000 9.58 B2M APP
10 regulation of T cell activation GO:0050863 9.56 CD4 CCL5
11 modulation of age-related behavioral decline GO:0090647 9.54 B2M APP
12 peripheral nervous system development GO:0007422 9.5 NGF GDNF BDNF
13 positive regulation of collateral sprouting GO:0048672 9.49 NGF BDNF
14 tachykinin receptor signaling pathway GO:0007217 9.48 TACR3 TAC1
15 positive regulation of receptor binding GO:1900122 9.46 BDNF B2M
16 positive regulation of T cell proliferation GO:0042102 9.46 IL6 CD40LG CD4 CCL5
17 immune response GO:0006955 9.28 MBP IL6 CXCL2 CD8A CD40LG CD4
18 response to peptidoglycan GO:0032494 9.13 IL6 CARD9 C5AR1

Molecular functions related to Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 TACR3 NLE1 NGF MBP IL6 GDNF
2 protein homodimerization activity GO:0042803 9.73 GDNF CD79A CD4 CCL5 CARD9 B2M
3 cytokine activity GO:0005125 9.46 IL6 CXCL2 CD40LG CCL5
4 growth factor activity GO:0008083 8.92 NGF IL6 GDNF BDNF
Sources

Sources for Meningoencephalitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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