MCID: MNN009
MIFTS: 49

Meningoencephalitis

Categories: Neuronal diseases

Aliases & Classifications for Meningoencephalitis

MalaCards integrated aliases for Meningoencephalitis:

Name: Meningoencephalitis 12 56 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10554
MeSH 45 D008590
NCIt 51 C34813
SNOMED-CT 69 7125002
ICD10 34 A69.22 G04
UMLS 74 C0025309

Summaries for Meningoencephalitis

Disease Ontology : 12 A central nervous system disease that involves encephalitis which occurs along with meningitis.

MalaCards based summary : Meningoencephalitis is related to parotitis and acquired immunodeficiency syndrome. An important gene associated with Meningoencephalitis is CARD9 (Caspase Recruitment Domain Family Member 9), and among its related pathways/superpathways are Neuroscience and Spinal Cord Injury. The drugs Fluconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include brain, b cells and pituitary, and related phenotypes are homeostasis/metabolism and behavior/neurological

Wikipedia : 77 Meningoencephalitis (/mɪˌnɪŋɡoʊɛnˌsɛfəˈlaɪtɪs, -ˌnɪndʒoʊ-, -ən-, -ˌkɛ-/; from Greek μῆνιγξ meninx,... more...

Related Diseases for Meningoencephalitis

Diseases related to Meningoencephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 386)
# Related Disease Score Top Affiliating Genes
1 parotitis 30.6 ALB CD79A
2 acquired immunodeficiency syndrome 30.6 ALB B2M IL6
3 toxoplasmosis 30.3 CD40LG CD79A IL6
4 otitis media 30.2 ALB CD79A IL6
5 human immunodeficiency virus infectious disease 30.1 B2M CCL5 IL6
6 peritonitis 30.1 ALB B2M IL6
7 pneumonia 30.0 CCL5 CD40LG IL6
8 syphilis 29.9 B2M CD40LG CD79A
9 legionnaires' disease 29.7 ALB SLC17A5 TNPO1
10 guillain-barre syndrome 29.7 ALB CD79A MBP
11 cytomegalovirus infection 29.7 B2M CCL5 IL6
12 aleutian mink disease 29.7 ALB CD40LG
13 myeloma, multiple 29.7 ALB B2M CD79A IL6
14 human immunodeficiency virus type 1 29.5 B2M CCL5 GDNF IL6
15 systemic lupus erythematosus 29.4 ALB CCL5 CD40LG CD79A IL6 MECP2
16 viral encephalitis 29.1 CCL5 IL6 MBP
17 peripheral nervous system disease 28.9 ALB IL6 MBP NGF TAC1
18 asthma 28.5 CCL5 CD40LG IL6 NGF TAC1
19 primary amebic meningoencephalitis 12.6
20 lymphocytic choriomeningitis 11.9
21 tick-borne encephalitis 11.4
22 trichinosis 11.4
23 pulmonary alveolar microlithiasis 11.1
24 parenchymatous neurosyphilis 11.1
25 tick infestation 11.1
26 amoebiasis due to free-living amoebae 11.1
27 listeriosis 10.6
28 mumps 10.5
29 tinea profunda 10.5 ALB CARD9
30 c1q nephropathy 10.5 CD40LG CD79A
31 immunoglobulin g deficiency 10.4 CD40LG CD79A
32 cryofibrinogenemia 10.4 CD40LG CD79A
33 fournier gangrene 10.4 ALB CD40LG
34 immunodeficiency 43 10.4 ALB B2M
35 root caries 10.4 ALB CD79A
36 meningitis 10.4
37 heparin-induced thrombocytopenia 10.4 CD40LG CD79A
38 immunoglobulin a deficiency 1 10.4 CD40LG CD79A
39 sporotrichosis 10.4 CD40LG CD79A
40 congenital syphilis 10.4 CD40LG CD79A
41 secondary syphilis 10.4 CD40LG CD79A
42 extramedullary plasmacytoma 10.4 B2M IL6
43 chronic graft versus host disease 10.4 ALB CD79A
44 orthostatic proteinuria 10.4 ALB B2M
45 diffuse glomerulonephritis 10.4 ALB B2M
46 focal dermal hypoplasia 10.4 ALB CD79A
47 ocular toxoplasmosis 10.3 CD40LG CD79A
48 west nile virus 10.3
49 hypersensitivity reaction type iii disease 10.3 ALB CD79A IL6
50 glomerulonephritis 10.3 ALB CD40LG CD79A

Graphical network of the top 20 diseases related to Meningoencephalitis:



Diseases related to Meningoencephalitis

Symptoms & Phenotypes for Meningoencephalitis

MGI Mouse Phenotypes related to Meningoencephalitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.15 ALB APP B2M CARD9 CD40LG CD79A
2 behavior/neurological MP:0005386 10.13 APP GDNF IL6 MBP MECP2 NGF
3 cellular MP:0005384 10.13 ALB APP B2M CD40LG CD79A GDNF
4 cardiovascular system MP:0005385 10.06 APP B2M CD40LG GDNF IL6 MECP2
5 hematopoietic system MP:0005397 10.06 APP B2M CARD9 CCL5 CD40LG CD79A
6 immune system MP:0005387 10.02 APP B2M CARD9 CCL5 CD40LG CD79A
7 nervous system MP:0003631 9.85 APP B2M CD40LG CD79A GDNF IL6
8 integument MP:0010771 9.8 APP B2M CD40LG IL6 MECP2 NGF
9 renal/urinary system MP:0005367 9.43 ALB CD40LG CD79A GDNF IL6 TAC1
10 reproductive system MP:0005389 9.23 APP B2M CD40LG GDNF IL6 MBP

Drugs & Therapeutics for Meningoencephalitis

Drugs for Meningoencephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved, Investigational Phase 3,Phase 2,Not Applicable 86386-73-4 3365
2
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Not Applicable 22916-47-8 4189
3
Sertraline Approved Phase 3 79617-96-2 68617
4 Immunoglobulins Phase 3,Phase 1,Phase 2
5 Antibodies Phase 3,Phase 1,Phase 2
6 Immunologic Factors Phase 3,Phase 2,Phase 1
7 Anti-Infective Agents Phase 3,Phase 2,Not Applicable
8 Neurotransmitter Agents Phase 3
9 Immunoglobulins, Intravenous Phase 3
10 Rho(D) Immune Globulin Phase 3
11 gamma-Globulins Phase 3
12 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 2,Not Applicable
13 Hormones Phase 3,Phase 2,Not Applicable
14 Cytochrome P-450 CYP2C19 Inhibitors Phase 3,Phase 2,Not Applicable
15 Steroid Synthesis Inhibitors Phase 3,Phase 2,Not Applicable
16 Cytochrome P-450 CYP2C9 Inhibitors Phase 3,Phase 2,Not Applicable
17 Antifungal Agents Phase 3,Phase 2,Not Applicable
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
19 Hormone Antagonists Phase 3,Phase 2,Not Applicable
20 Antidepressive Agents Phase 3
21 Serotonin Uptake Inhibitors Phase 3
22 Serotonin Agents Phase 3
23 Psychotropic Drugs Phase 3
24 Neurotransmitter Uptake Inhibitors Phase 3
25
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
26
Aluminum sulfate Approved Phase 2 10043-01-3
27
Aluminum hydroxide Approved, Investigational Phase 2 21645-51-2
28
Tamoxifen Approved Phase 2 10540-29-1 2733526
29
Amphotericin B Approved, Investigational Phase 2 1397-89-3 5280965 14956
30 Antibodies, Monoclonal Phase 1, Phase 2
31 Vaccines Phase 2,Phase 1
32 Gastrointestinal Agents Phase 2
33 Antacids Phase 2
34 Anti-Ulcer Agents Phase 2
35 Adjuvants, Immunologic Phase 2
36 Antiprotozoal Agents Phase 2
37 Antiparasitic Agents Phase 2
38 Anti-Bacterial Agents Phase 2
39 Estrogen Receptor Modulators Phase 2
40 Estrogen Receptor Antagonists Phase 2
41 Cytochrome P-450 CYP3A Inhibitors Phase 2
42 Antineoplastic Agents, Hormonal Phase 2
43 Selective Estrogen Receptor Modulators Phase 2
44 Liposomal amphotericin B Phase 2
45 Bone Density Conservation Agents Phase 2
46 Estrogens Phase 2
47 Estrogen Antagonists Phase 2
48
Ceftriaxone Approved 73384-59-5 5479530 5361919
49
Dopamine Approved 62-31-7, 51-61-6 681
50
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Investigating the Role of Early Intravenous Immunoglobulin Treatment for Children With Encephalitis Active, not recruiting NCT02308982 Phase 3 Immunoglobulins, Intravenous (Privigen);Placebo
2 Cryptococcal Antigen Screening Plus Sertraline Terminated NCT03002012 Phase 3 Sertraline;Placebo Oral Tablet;Fluconazole
3 Phase Ib Study of SC Milatuzumab in SLE Unknown status NCT01845740 Phase 1, Phase 2 milatuzumab;Placebo
4 A Phase II Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants Completed NCT01399853 Phase 2
5 A Booster Dose of Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children Completed NCT01734408 Phase 2
6 Treatment With Tamoxifen in Cryptococcal Meningitis Active, not recruiting NCT03112031 Phase 2 Tamoxifen;Amphotericin B;Fluconazole
7 A Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants Completed NCT01313715 Phase 1
8 A Clinical Trial for Inactivated Vaccine(Vero Cell) Against EV71 in Chinese Healthy Young Adults and Children Completed NCT01267903 Phase 1
9 Pharmacokinetic Study in Cerebral Spinal Fluid After a Single Dose of AVI-4020 Completed NCT00387283 Phase 1 AVI-4020 Injection
10 Study Assessing Tolerability and Safety of AFFITOPE® PD03A in Patients With Early Parkinson's Disease Completed NCT02267434 Phase 1
11 Study Assessing Safety and Therapeutic Activity of AFFITOPE® PD01A and PD03A in Patients With Early MSA Completed NCT02270489 Phase 1
12 An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
13 Etiology of Orphan Community-based Meningitis and Meningo-encephalitis. Unknown status NCT02868593 Not Applicable
14 Rijavithi Viral and Mycobacterium PCR Arrays in CNS Infection Study Completed NCT00807378
15 Herpes Zoster: Risk Factors, Complications and Special Situations Completed NCT03903237
16 Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus Completed NCT00858884 Not Applicable
17 Magnetic Resonance Spectroscopy, Perfusion, and Diffusion Tensor Imaging in Neuropsychiatric Lupus Completed NCT00730002 Not Applicable
18 Magnetic Resonance Spectroscopy, Perfusion and Diffusion Tensor Imaging in Neuropsychiatric Lupus Completed NCT00723671 Not Applicable
19 Aseptic Meningoencephalitis in Slovenia Recruiting NCT02328469 symptomatic therapy;Ceftriaxone or Doxycycline;Acyclovir
20 Driving Reduced AIDS-associated Meningo-encephalitis Mortality Recruiting NCT03226379
21 EURopean Study on Encephalitis in Intensive CAre Recruiting NCT03144570
22 Research for Angiostrongylus Cantonensis and Costaricensis in French West Indies and French Guiana Recruiting NCT03378882
23 Fever After Tick Bite Study Recruiting NCT03932448
24 Identification and Quantification of HIV CNS Latency Biomarkers Recruiting NCT02989285
25 Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients Active, not recruiting NCT02207647
26 Pre-Antiretroviral Therapy (ART) Cryptococcal Antigen Screening in AIDS Active, not recruiting NCT02624453 Not Applicable Fluconazole;Antiretroviral therapy
27 Development of a Novel Glutamate Receptor Ligand for PET Scans in Neuropsychiatric Systemic Lupus Erythematosus Active, not recruiting NCT02456168

Search NIH Clinical Center for Meningoencephalitis

Cochrane evidence based reviews: meningoencephalitis

Genetic Tests for Meningoencephalitis

Anatomical Context for Meningoencephalitis

MalaCards organs/tissues related to Meningoencephalitis:

42
Brain, B Cells, Pituitary, Bone, T Cells, Kidney, Liver

Publications for Meningoencephalitis

Articles related to Meningoencephalitis:

(show top 50) (show all 1819)
# Title Authors Year
1
Viral metagenomics revealed novel betatorquevirus species in pediatric inpatients with encephalitis/meningoencephalitis from Ghana. ( 30787417 )
2019
2
Prevalence of herpes simplex virus-1 in hospitalized adult patients with clinical diagnosis of meningoencephalitis using real-time polymerase chain reaction: A single-center, cross-sectional study. ( 30815020 )
2019
3
Vibrio vulnificus meningoencephalitis in a patient with thalassemia and a splenectomy. ( 30397825 )
2019
4
Cryptococcal meningoencephalitis in an elderly immunocompetent non-HIV-infected patient. ( 30472030 )
2019
5
Neonatal meningoencephalitis caused by human adenovirus species F infection. ( 30632227 )
2019
6
Oropouche Virus-Associated Aseptic Meningoencephalitis, Southeastern Brazil. ( 30666950 )
2019
7
Pseudomonas meningoencephalitis masquerading as a stroke in a patient on tocilizumab. ( 30696642 )
2019
8
Commentary: Cerebrospinal fluid changes in cattle with rabies or with BoHV-5 meningoencephalitis and its correlation with the severity of CNS inflammatory process. ( 30704752 )
2019
9
Meningoencephalitis Following Endoscopic Dacryocystorhinostomy. ( 30730432 )
2019
10
The role of CNS macrophages in streptococcal meningoencephalitis. ( 30762892 )
2019
11
Legionnaire's-disease-associated meningoencephalitis: A case report. ( 30782478 )
2019
12
Cerebral vasculitis associated with an Echovirus 6 meningoencephalitis-Case report and review of the literature. ( 30847187 )
2019
13
Lymphoplasmacytic Meningoencephalitis and Neuronal Necrosis Associated With Parvoviral Infection in Cats. ( 30917745 )
2019
14
Meningoencephalitis Caused by a Campylobacter fetus in a Patient with Chronic Alcoholism. ( 30918169 )
2019
15
Lethal encounters: The evolving spectrum of amoebic meningoencephalitis. ( 30937287 )
2019
16
Unusual cause of progressively impaired cognitive function: Mycobacterium avium complex meningoencephalitis. ( 30948407 )
2019
17
A local case of fulminant primary amoebic meningoencephalitis due to Naegleria fowleri. ( 30961348 )
2019
18
Disruption of blood-brain barrier by an Escherichia coli isolated from canine septicemia and meningoencephalitis. ( 30961817 )
2019
19
Low frequency of pre-treatment and post-treatment haematological abnormalities in dogs with non-infectious meningoencephalitis treated with cytosine arabinoside and prednisolone. ( 30997113 )
2019
20
Long-Segment Myelitis, Meningoencephalitis, and Axonal Polyneuropathy in a Case of Scrub Typhus. ( 31007446 )
2019
21
Cryptococcal Meningoencephalitis Presenting as a Psychiatric Emergency. ( 31014972 )
2019
22
Relapsing optic neuritis and meningoencephalitis in a child: case report of delayed diagnosis of MOG-IgG syndrome. ( 31072329 )
2019
23
Tuberculous meningoencephalitis in patient with HIV-infection. ( 31076760 )
2019
24
Histological and virological findings in severe meningoencephalitis associated with border disease virus in Alpine chamois (Rupicapra rupicapra rupicapra) in Aosta Valley, Italy. ( 31086771 )
2019
25
A comprehensive profile of the tilapia (Oreochromis niloticus) circular RNA and circRNA-miRNA network in the pathogenesis of meningoencephalitis of teleosts. ( 31098608 )
2019
26
Diagnostic approach to encephalitis and meningoencephalitis in adult returning travellers. ( 30708123 )
2019
27
Encephalitis and meningoencephalitis: chasing the culprit. ( 30703529 )
2019
28
Diagnostic tools to tackle infectious causes of encephalitis and meningoencephalitis in immunocompetent adults in Europe. ( 30654044 )
2019
29
High-throughput sequencing for the aetiologic identification of viral encephalitis, meningoencephalitis and meningitis. A narrative review and clinical appraisal. ( 30641229 )
2019
30
A case series of fatal meningoencephalitis in Mongolia: epidemiological and molecular characteristics of tick-borne encephalitis virus. ( 31110839 )
2019
31
Human adenovirus meningoencephalitis: a 3-years' overview. ( 31102186 )
2019
32
Co-infection ZIKV and HSV-1 associated with meningoencephalitis: Case report and literature review. ( 29703710 )
2019
33
Serological prevalence of toxoplasmosis and neosporosis in dogs diagnosed with suspected meningoencephalitis in the UK. ( 30371939 )
2019
34
Phenotypic Screens Reveal Posaconazole as a Rapidly Acting Amebicidal Combination Partner for Treatment of Primary Amoebic Meningoencephalitis. ( 30358879 )
2019
35
Atypical Anti-MOG syndrome with aseptic meningoencephalitis and pseudotumor cerebri-like presentations. ( 30300850 )
2019
36
Meningoencephalitis caused by Lactobacillus plantarum - case report. ( 29813007 )
2019
37
Ehrlichiosis presenting as severe sepsis and meningoencephalitis in an immunocompetent adult. ( 30425837 )
2018
38
Rapidly progressive encephalopathy caused by Coxsackie meningoencephalitis in an elderly male. ( 30291563 )
2018
39
Streptococcus agalactiae meningoencephalitis associated with gastroesophageal reflux disease and chronic proton pump inhibitors use, in a 9 month-old infant: a case report. ( 29390957 )
2018
40
Magnetic resonance imaging features of gelatinous pseudocysts in cryptococcal meningoencephalitis. ( 30374842 )
2018
41
Relapsing Polychondritis with Meningoencephalitis Refractory to Immunosuppressant Therapy. ( 30402308 )
2018
42
Acute enteroviral meningoencephalitis as unusual cause of diplopia in pregnancy and puerperium. ( 30441959 )
2018
43
Human Chronic Necrotizing Granulomatous Meningoencephalitis: A Novel Case Report. ( 30483106 )
2018
44
Chronic meningoencephalitis with mixed pathology mimics progressive supranuclear palsy. ( 30567127 )
2018
45
Autoimmune inflammatory meningoencephalitis in a patient negative for glial fibrillary acidic protein-specific immunoglobulin G. ( 30605794 )
2018
46
Rheumatoid Meningoencephalitis: A Feared Condition in the Era of TNF Blockers. ( 30652043 )
2018
47
Canine amoebic meningoencephalitis due to Balamuthia mandrillaris. ( 31014865 )
2018
48
Report of two cases of tocilizumab induced recurrent meningitis or meningoencephalitis. ( 29366968 )
2018
49
Cryptococcal meningoencephalitis in patients with mantle cell lymphoma on ibrutinib. ( 29910833 )
2018
50
Lymphocytic choriomeningitis virus meningoencephalitis in a renal transplant recipient following exposure to mice. ( 30325104 )
2018

Variations for Meningoencephalitis

Expression for Meningoencephalitis

Search GEO for disease gene expression data for Meningoencephalitis.

Pathways for Meningoencephalitis

Pathways related to Meningoencephalitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.09 APP MBP MECP2 NGF
2 11.58 GDNF IL6 MBP
3 11.54 B2M CARD9 CCL5 CD40LG CD79A
4 11.47 IL6 MECP2 NGF TAC1
5 11.13 CCL5 IL6 MECP2

GO Terms for Meningoencephalitis

Cellular components related to Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 ALB APP B2M CCL5 CD40LG GDNF
2 endoplasmic reticulum lumen GO:0005788 9.46 ALB APP B2M IL6
3 extracellular space GO:0005615 9.28 ALB APP B2M CCL5 CD40LG IL6

Biological processes related to Meningoencephalitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.85 ALB CD40LG GDNF IL6 NGF
2 inflammatory response GO:0006954 9.81 CCL5 CD40LG IL6 TAC1
3 immune response GO:0006955 9.8 B2M CCL5 CD40LG IL6 MBP
4 negative regulation of neuron apoptotic process GO:0043524 9.7 GDNF MECP2 NGF
5 cellular protein metabolic process GO:0044267 9.62 ALB APP B2M IL6
6 regulation of signaling receptor activity GO:0010469 9.55 CCL5 CD40LG GDNF IL6 NGF
7 positive regulation of T cell migration GO:2000406 9.49 APP CCL5
8 positive regulation of acute inflammatory response GO:0002675 9.48 IL6 TAC1
9 tachykinin receptor signaling pathway GO:0007217 9.43 TAC1 TACR3
10 positive regulation of T cell proliferation GO:0042102 9.43 CCL5 CD40LG IL6
11 response to peptidoglycan GO:0032494 9.37 CARD9 IL6
12 adult locomotory behavior GO:0008344 9.13 APP GDNF MECP2
13 neuron projection development GO:0031175 8.92 APP GDNF IL6 MECP2

Molecular functions related to Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.47 ALB APP B2M CARD9 CCL5 CD40LG

Sources for Meningoencephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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