MCID: MNN009
MIFTS: 50

Meningoencephalitis

Categories: Neuronal diseases

Aliases & Classifications for Meningoencephalitis

MalaCards integrated aliases for Meningoencephalitis:

Name: Meningoencephalitis 12 56 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10554
MeSH 45 D008590
NCIt 51 C34813
SNOMED-CT 69 7125002
ICD10 34 A69.22 G04
UMLS 74 C0025309

Summaries for Meningoencephalitis

Disease Ontology : 12 A central nervous system disease that involves encephalitis which occurs along with meningitis.

MalaCards based summary : Meningoencephalitis is related to acquired immunodeficiency syndrome and parotitis. An important gene associated with Meningoencephalitis is CARD9 (Caspase Recruitment Domain Family Member 9), and among its related pathways/superpathways are NF-kappaB Signaling and Immune response IFN gamma signaling pathway. The drugs Miconazole and Fluconazole have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and t cells, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 77 Meningoencephalitis (/mɪˌnɪŋɡoʊɛnˌsɛfəˈlaɪtɪs, -ˌnɪndʒoʊ-, -ən-, -ˌkɛ-/; from Greek μῆνιγξ meninx,... more...

Related Diseases for Meningoencephalitis

Diseases related to Meningoencephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 362)
# Related Disease Score Top Affiliating Genes
1 acquired immunodeficiency syndrome 30.5 ALB B2M IL6
2 parotitis 30.5 ALB CD79A
3 toxoplasmosis 30.3 CD40LG CD79A IL6
4 otitis media 30.2 ALB CD79A IL6
5 human immunodeficiency virus infectious disease 30.1 B2M CCL5 IL6
6 peritonitis 30.0 ALB B2M IL6
7 pneumonia 30.0 CCL5 CD40LG IL6
8 syphilis 29.8 B2M CD40LG CD79A
9 guillain-barre syndrome 29.7 ALB CD79A MBP
10 cytomegalovirus infection 29.6 B2M CCL5 IL6
11 myeloma, multiple 29.6 ALB B2M CD79A IL6
12 systemic lupus erythematosus 29.4 ALB CCL5 CD40LG CD79A IL6 MECP2
13 peripheral nervous system disease 29.4 ALB IL6 MBP TAC1
14 multiple sclerosis 29.3 BDNF CCL5 IL6 MBP
15 human immunodeficiency virus type 1 29.2 B2M CCL5 GDNF IL6
16 viral encephalitis 29.1 CCL5 IL6 MBP
17 relapsing-remitting multiple sclerosis 28.9 BDNF CCL5 MBP
18 asthma 28.6 BDNF CCL5 CD40LG IL6 TAC1
19 primary amebic meningoencephalitis 12.6
20 lymphocytic choriomeningitis 11.9
21 tick-borne encephalitis 11.4
22 trichinosis 11.4
23 pulmonary alveolar microlithiasis 11.0
24 parenchymatous neurosyphilis 11.0
25 tick infestation 11.0
26 amoebiasis due to free-living amoebae 11.0
27 listeriosis 10.6
28 mumps 10.5
29 tinea profunda 10.4 ALB CARD9
30 c1q nephropathy 10.4 CD40LG CD79A
31 immunoglobulin g deficiency 10.4 CD40LG CD79A
32 cryofibrinogenemia 10.4 CD40LG CD79A
33 meningitis 10.4
34 fournier gangrene 10.4 ALB CD40LG
35 immunodeficiency 43 10.4 ALB B2M
36 heparin-induced thrombocytopenia 10.4 CD40LG CD79A
37 root caries 10.4 ALB CD79A
38 immunoglobulin a deficiency 1 10.4 CD40LG CD79A
39 sporotrichosis 10.4 CD40LG CD79A
40 congenital syphilis 10.4 CD40LG CD79A
41 extramedullary plasmacytoma 10.3 B2M IL6
42 hypersensitivity reaction type iii disease 10.3 ALB CD79A IL6
43 secondary syphilis 10.3 CD40LG CD79A
44 west nile virus 10.3
45 glomerulonephritis 10.3 ALB CD40LG CD79A
46 keratoconjunctivitis sicca 10.3 ALB CD79A IL6
47 herpes simplex 10.3
48 chronic graft versus host disease 10.3 ALB CD79A
49 orthostatic proteinuria 10.3 ALB B2M
50 diffuse glomerulonephritis 10.3 ALB B2M

Graphical network of the top 20 diseases related to Meningoencephalitis:



Diseases related to Meningoencephalitis

Symptoms & Phenotypes for Meningoencephalitis

MGI Mouse Phenotypes related to Meningoencephalitis:

47 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.22 ALB APP B2M BDNF CD40LG CD79A
2 homeostasis/metabolism MP:0005376 10.18 ALB APP B2M BDNF CARD9 CD40LG
3 behavior/neurological MP:0005386 10.16 APP BDNF CREBBP GDNF IL6 MBP
4 hematopoietic system MP:0005397 10.13 APP B2M CARD9 CCL5 CD40LG CD79A
5 endocrine/exocrine gland MP:0005379 10.11 ALB B2M BDNF CD40LG CREBBP GDNF
6 immune system MP:0005387 10.11 APP B2M CARD9 CCL5 CD40LG CD79A
7 cardiovascular system MP:0005385 10.1 APP B2M CD40LG CREBBP GDNF IL6
8 nervous system MP:0003631 9.96 APP B2M BDNF CD40LG CD79A CREBBP
9 integument MP:0010771 9.92 APP B2M BDNF CD40LG CREBBP IL6
10 normal MP:0002873 9.76 ALB APP BDNF CD79A CREBBP MBP
11 renal/urinary system MP:0005367 9.43 ALB CD40LG CD79A GDNF IL6 TAC1
12 reproductive system MP:0005389 9.28 APP B2M BDNF CD40LG GDNF IL6

Drugs & Therapeutics for Meningoencephalitis

Drugs for Meningoencephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Not Applicable 22916-47-8 4189
2
Fluconazole Approved, Investigational Phase 3,Phase 2,Not Applicable 86386-73-4 3365
3
Sertraline Approved Phase 3 79617-96-2 68617
4 Immunoglobulins Phase 3,Phase 1,Phase 2
5 Antibodies Phase 3,Phase 1,Phase 2
6 Immunologic Factors Phase 3,Phase 2,Phase 1
7 Neurotransmitter Agents Phase 3
8 Anti-Infective Agents Phase 3,Phase 2,Not Applicable
9 Rho(D) Immune Globulin Phase 3
10 gamma-Globulins Phase 3
11 Immunoglobulins, Intravenous Phase 3
12 Hormone Antagonists Phase 3,Phase 2,Not Applicable
13 Antifungal Agents Phase 3,Phase 2,Not Applicable
14 Cytochrome P-450 CYP2C9 Inhibitors Phase 3,Phase 2,Not Applicable
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
16 Steroid Synthesis Inhibitors Phase 3,Phase 2,Not Applicable
17 Hormones Phase 3,Phase 2,Not Applicable
18 Cytochrome P-450 CYP2C19 Inhibitors Phase 3,Phase 2,Not Applicable
19 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 2,Not Applicable
20 Serotonin Agents Phase 3
21 Serotonin Uptake Inhibitors Phase 3
22 Psychotropic Drugs Phase 3
23 Neurotransmitter Uptake Inhibitors Phase 3
24 Antidepressive Agents Phase 3
25
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
26
Aluminum sulfate Approved Phase 2 10043-01-3
27
Aluminum hydroxide Approved, Investigational Phase 2 21645-51-2
28
Tamoxifen Approved Phase 2 10540-29-1 2733526
29
Amphotericin B Approved, Investigational Phase 2 1397-89-3 14956 5280965
30 Antibodies, Monoclonal Phase 1, Phase 2
31 Vaccines Phase 2,Phase 1
32 Anti-Ulcer Agents Phase 2
33 Adjuvants, Immunologic Phase 2
34 Gastrointestinal Agents Phase 2
35 Antacids Phase 2
36 Antiprotozoal Agents Phase 2
37 Antiparasitic Agents Phase 2
38 Anti-Bacterial Agents Phase 2
39 Estrogens Phase 2
40 Estrogen Receptor Modulators Phase 2
41 Selective Estrogen Receptor Modulators Phase 2
42 Antineoplastic Agents, Hormonal Phase 2
43 Cytochrome P-450 CYP3A Inhibitors Phase 2
44 Estrogen Receptor Antagonists Phase 2
45 Liposomal amphotericin B Phase 2
46 Bone Density Conservation Agents Phase 2
47 Estrogen Antagonists Phase 2
48
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
49
Dopamine Approved 62-31-7, 51-61-6 681
50
Ceftriaxone Approved 73384-59-5 5479530 5361919

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Investigating the Role of Early Intravenous Immunoglobulin Treatment for Children With Encephalitis Active, not recruiting NCT02308982 Phase 3 Immunoglobulins, Intravenous (Privigen);Placebo
2 Cryptococcal Antigen Screening Plus Sertraline Terminated NCT03002012 Phase 3 Sertraline;Placebo Oral Tablet;Fluconazole
3 Phase Ib Study of SC Milatuzumab in SLE Unknown status NCT01845740 Phase 1, Phase 2 milatuzumab;Placebo
4 A Phase II Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants Completed NCT01399853 Phase 2
5 A Booster Dose of Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children Completed NCT01734408 Phase 2
6 Treatment With Tamoxifen in Cryptococcal Meningitis Active, not recruiting NCT03112031 Phase 2 Tamoxifen;Amphotericin B;Fluconazole
7 A Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants Completed NCT01313715 Phase 1
8 A Clinical Trial for Inactivated Vaccine(Vero Cell) Against EV71 in Chinese Healthy Young Adults and Children Completed NCT01267903 Phase 1
9 Pharmacokinetic Study in Cerebral Spinal Fluid After a Single Dose of AVI-4020 Completed NCT00387283 Phase 1 AVI-4020 Injection
10 Study Assessing Tolerability and Safety of AFFITOPE® PD03A in Patients With Early Parkinson's Disease Completed NCT02267434 Phase 1
11 Study Assessing Safety and Therapeutic Activity of AFFITOPE® PD01A and PD03A in Patients With Early MSA Completed NCT02270489 Phase 1
12 An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
13 Etiology of Orphan Community-based Meningitis and Meningo-encephalitis. Unknown status NCT02868593 Not Applicable
14 Rijavithi Viral and Mycobacterium PCR Arrays in CNS Infection Study Completed NCT00807378
15 Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus Completed NCT00858884 Not Applicable
16 Magnetic Resonance Spectroscopy, Perfusion, and Diffusion Tensor Imaging in Neuropsychiatric Lupus Completed NCT00730002 Not Applicable
17 Magnetic Resonance Spectroscopy, Perfusion and Diffusion Tensor Imaging in Neuropsychiatric Lupus Completed NCT00723671 Not Applicable
18 Aseptic Meningoencephalitis in Slovenia Recruiting NCT02328469 symptomatic therapy;Ceftriaxone or Doxycycline;Acyclovir
19 Driving Reduced AIDS-associated Meningo-encephalitis Mortality Recruiting NCT03226379
20 EURopean Study on Encephalitis in Intensive CAre Recruiting NCT03144570
21 Research for Angiostrongylus Cantonensis and Costaricensis in French West Indies and French Guiana Recruiting NCT03378882
22 Identification and Quantification of HIV CNS Latency Biomarkers Recruiting NCT02989285
23 Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients Active, not recruiting NCT02207647
24 Pre-Antiretroviral Therapy (ART) Cryptococcal Antigen Screening in AIDS Active, not recruiting NCT02624453 Not Applicable Fluconazole;Antiretroviral therapy
25 Development of a Novel Glutamate Receptor Ligand for PET Scans in Neuropsychiatric Systemic Lupus Erythematosus Active, not recruiting NCT02456168

Search NIH Clinical Center for Meningoencephalitis

Cochrane evidence based reviews: meningoencephalitis

Genetic Tests for Meningoencephalitis

Anatomical Context for Meningoencephalitis

MalaCards organs/tissues related to Meningoencephalitis:

42
Brain, Bone, T Cells, Kidney, Pituitary, Testes, Bone Marrow

Publications for Meningoencephalitis

Articles related to Meningoencephalitis:

(show top 50) (show all 1803)
# Title Authors Year
1
High-throughput sequencing for the aetiologic identification of viral encephalitis, meningoencephalitis, and meningitis. A narrative review and clinical appraisal. ( 30641229 )
2019
2
Diagnostic tools to tackle infectious causes of Encephalitis and Meningoencephalitis in immunocompetent adults in Europe. ( 30654044 )
2019
3
Encephalitis and meningoencephalitis: chasing the culprit. ( 30703529 )
2019
4
Diagnostic approach to Encephalitis and Meningoencephalitis in Adult Returning Travellers. ( 30708123 )
2019
5
Viral metagenomics revealed novel betatorquevirus species in pediatric inpatients with encephalitis/meningoencephalitis from Ghana. ( 30787417 )
2019
6
Prevalence of herpes simplex virus-1 in hospitalized adult patients with clinical diagnosis of meningoencephalitis using real-time polymerase chain reaction: A single-center, cross-sectional study. ( 30815020 )
2019
7
Cryptococcal meningoencephalitis in an elderly immunocompetent non-HIV-infected patient. ( 30472030 )
2019
8
Neonatal meningoencephalitis caused by human adenovirus species F infection. ( 30632227 )
2019
9
Oropouche Virus-Associated Aseptic Meningoencephalitis, Southeastern Brazil. ( 30666950 )
2019
10
Pseudomonas meningoencephalitis masquerading as a stroke in a patient on tocilizumab. ( 30696642 )
2019
11
Commentary: Cerebrospinal fluid changes in cattle with rabies or with BoHV-5 meningoencephalitis and its correlation with the severity of CNS inflammatory process. ( 30704752 )
2019
12
Meningoencephalitis Following Endoscopic Dacryocystorhinostomy. ( 30730432 )
2019
13
The role of CNS macrophages in streptococcal meningoencephalitis. ( 30762892 )
2019
14
Legionnaire's-disease-associated meningoencephalitis: A case report. ( 30782478 )
2019
15
Cerebral vasculitis associated with an Echovirus 6 meningoencephalitis-Case report and review of the literature. ( 30847187 )
2019
16
Neospora caninum and Ehrlichia canis co-infection in a dog with meningoencephalitis. ( 29406569 )
2018
17
Pharmacodynamics of Flubendazole for Cryptococcal Meningoencephalitis: Repurposing and Reformulation of an Anti-Parasitic Agent for a Neglected Fungal Disease. ( 29311092 )
2018
18
Streptococcus agalactiae meningoencephalitis associated with gastroesophageal reflux disease and chronic proton pump inhibitors use, in a 9A month-old infant: a case report. ( 29390957 )
2018
19
Influenza B-related meningoencephalitis in adults. ( 29930187 )
2018
20
Cerebrospinal fluid changes in cattle with rabies or with BoHV-5 meningoencephalitis and its correlation with the severity of CNS inflammatory process. ( 29684815 )
2018
21
Sonographic Diagnosis of Meningoencephalitis in Newborns and Infants. ( 29534259 )
2018
22
Chronic meningoencephalitis caused by Echo virusA 6 in aA patient with common variable immunodeficiency : Successful treatment with pleconaril. ( 29116409 )
2018
23
Estimation of Undiagnosed Naegleria fowleri Primary Amebic Meningoencephalitis, United States<sup>1</sup>. ( 29260676 )
2018
24
Systemic Staphylococcus pseudintermedius infection in an arctic fox (Vulpes lagopus) with severe multifocal suppurative meningoencephalitis and nephritis. ( 29887579 )
2018
25
A four-year survey (2011-2014) of West Nile virus infection in humans, mosquitoes and birds, including the 2012 meningoencephalitis outbreak in Tunisia. ( 29535295 )
2018
26
Rheumatoid disease: an unusual cause of relapsing meningoencephalitis. ( 29330273 )
2018
27
Clinical presentation and magnetic resonance imaging findings in 11 dogs with eosinophilic meningoencephalitis of unknown aetiology. ( 29603737 )
2018
28
Lyme Meningoencephalitis Masquerading as Normal Pressure Hydrocephalus. ( 29872598 )
2018
29
Nurse's guide to primary amebic meningoencephalitis. ( 29561369 )
2018
30
An uncommon complication of <i>Listeria monocytogenes</i> infection: Polyradiculoneuritis following Listeria meningoencephalitis. ( 29942763 )
2018
31
Emergency Foramen Magnum Decompression for Tonsillar Herniation Secondary to Meningoencephalitis. ( 29681828 )
2018
32
Primary Amebic Meningoencephalitis Associated With Rafting on an Artificial Whitewater River: Case Report and Environmental Investigation. ( 29401275 )
2018
33
Parasitic and zoonotic meningoencephalitis in humans and equids: Current knowledge and the role of <i>Halicephalobus gingivalis</i>. ( 29774297 )
2018
34
Identification and molecular typing of Naegleria fowleri from a patient with primary amebic meningoencephalitis in China. ( 29751112 )
2018
35
Pleocytosis in a patient with relapsing polychondritis accompanied by meningoencephalitis: a case report. ( 29699514 )
2018
36
Acute Disseminated Encephalomyelitis After Herpes Simplex Virus Meningoencephalitis in Adult. ( 29581077 )
2018
37
Cryptococcal meningoencephalitis in patients with mantle cell lymphoma on ibrutinib. ( 29910833 )
2018
38
Co-infection ZIKV and HSV-1 associated with meningoencephalitis: Case report and literature review. ( 29703710 )
2018
39
Clinical Images: A Rare Case of Cryptococcal Meningoencephalitis in an Immunocompetent Patient. ( 29559862 )
2018
40
Mortality from Listeria monocytogenes meningoencephalitis following escalation to alemtuzumab therapy for relapsing-remitting Multiple Sclerosis. ( 29885597 )
2018
41
Report of two cases of tocilizumab induced recurrent meningitis or meningoencephalitis. ( 29366968 )
2018
42
<i>Mycoplasma pneumoniae</i> infection presenting as stroke and meningoencephalitis with aortic and subclavian aneurysms without pulmonary involvement. ( 29326371 )
2018
43
Meningoencephalitis caused by Lactobacillus plantarum - case report. ( 29813007 )
2018
44
Jamestown Canyon virus meningoencephalitis mimicking migraine with aura in a resident of Manitoba. ( 29507158 )
2018
45
Diabetes insipidus secondary to tuberculous meningoencephalitis with hypothalamic involvement extending to the hypophysis: a case report. ( 30517545 )
2018
46
Ehrlichiosis presenting as severe sepsis and meningoencephalitis in an immunocompetent adult. ( 30425837 )
2018
47
Rapidly progressive encephalopathy caused by Coxsackie meningoencephalitis in an elderly male. ( 30291563 )
2018
48
A Fatal Case of Atypical Disseminated Herpes Zoster in a Patient with Meningoencephalitis and Seizures Associated with Steroid Immunosuppression. ( 30270342 )
2018
49
Three children of meningoencephalitis with Kikuchi necrotizing lymphadenitis. ( 29050838 )
2018
50
Corticosteroids for shunted previously healthy patients with non-HIV cryptococcal meningoencephalitis. ( 28550070 )
2018

Variations for Meningoencephalitis

Expression for Meningoencephalitis

Search GEO for disease gene expression data for Meningoencephalitis.

Pathways for Meningoencephalitis

GO Terms for Meningoencephalitis

Cellular components related to Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 ALB APP B2M BDNF CCL5 CD40LG
2 endoplasmic reticulum lumen GO:0005788 9.46 ALB APP B2M IL6
3 extracellular space GO:0005615 9.28 ALB APP B2M BDNF CCL5 CD40LG

Biological processes related to Meningoencephalitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.83 B2M CCL5 CD40LG IL6 MBP
2 inflammatory response GO:0006954 9.81 CCL5 CD40LG IL6 TAC1
3 negative regulation of neuron apoptotic process GO:0043524 9.7 BDNF GDNF MECP2
4 cellular protein metabolic process GO:0044267 9.62 ALB APP B2M IL6
5 regulation of signaling receptor activity GO:0010469 9.55 BDNF CCL5 CD40LG GDNF IL6
6 positive regulation of T cell migration GO:2000406 9.49 APP CCL5
7 positive regulation of acute inflammatory response GO:0002675 9.48 IL6 TAC1
8 tachykinin receptor signaling pathway GO:0007217 9.46 TAC1 TACR3
9 positive regulation of T cell proliferation GO:0042102 9.43 CCL5 CD40LG IL6
10 positive regulation of receptor binding GO:1900122 9.4 B2M BDNF
11 response to peptidoglycan GO:0032494 9.37 CARD9 IL6
12 adult locomotory behavior GO:0008344 9.13 APP GDNF MECP2
13 neuron projection development GO:0031175 8.92 APP GDNF IL6 MECP2

Molecular functions related to Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.47 ALB APP B2M CARD9 CCL5 CD40LG

Sources for Meningoencephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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