Meningoencephalitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Meningoencephalitis, also known as meningoencephalitis due to acquired toxoplasmosis, is related to meningitis and toxoplasmosis. An important gene associated with Meningoencephalitis is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Amphotericin B and Fluconazole have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and t cells, and related phenotypes are homeostasis/metabolism and nervous system

Wikipedia: ⁷⁵ Meningoencephalitis (/mɪˌnɪŋɡoʊɛnˌsɛfəˈlaɪtɪs, -ˌnɪndʒoʊ-, -ən-, -ˌkɛ-/; from Ancient Greek: μῆνιγξ,... more...

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Related Diseases for Meningoencephalitis

Diseases related to Meningoencephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 898)

#	Related Disease	Score	Top Affiliating Genes
1	meningitis	32.1	IL6 GDNF CXCL2 CCL5 ALB
2	toxoplasmosis	31.3	IL6 CD79A CD40LG
3	acquired immunodeficiency syndrome	31.1	IL6 CD79A CD40LG B2M ALB
4	vasculitis	31.1	SH2D1A IL6 CD79A CD40LG
5	hydrocephalus	31.1	NGF GDNF BDNF APP
6	agammaglobulinemia	31.0	SH2D1A IL6 CD79A CD40LG
7	viral infectious disease	31.0	IL6 CXCR3 CD40LG CCL5 B2M
8	myocarditis	30.9	IL6 CD40LG CCL5 ALB
9	optic neuritis	30.9	IL6 CXCR3 BDNF
10	brain edema	30.9	IL6 CLDN5 ALB
11	neuritis	30.8	IL6 GDNF CCL5 BDNF
12	endophthalmitis	30.8	IL6 CARD9 ALB
13	respiratory failure	30.8	TAC1 IL6 CCL5 ALB
14	central nervous system disease	30.8	NGF CXCR3 BDNF APP
15	viral meningitis	30.7	IL6 CXCR3 CCL5 B2M ALB
16	pleural empyema	30.7	IL6 CD79A ALB
17	otitis media	30.7	IL6 CD79A CD40LG CCL5 ALB
18	guillain-barre syndrome	30.6	CD79A CD40LG ALB
19	immune deficiency disease	30.6	SH2D1A IL6 CXCR3 CD79A CD40LG CCL5
20	rabies	30.6	CD40LG CCL5 ALB
21	trypanosomiasis	30.6	IL6 CXCR3 ALB
22	peritonitis	30.6	IL6 CXCL2 B2M ALB
23	candidiasis	30.5	SH2D1A IL6 CARD9
24	dengue disease	30.5	IL6 CD40LG CCL5 ALB
25	sarcoidosis 1	30.5	TAC1 IL6 CXCR3 CCL5 ALB
26	alcohol use disorder	30.5	IL6 BDNF ALB
27	cerebritis	30.5	IL6 ALB
28	amebiasis	30.5	IL6 CD79A ALB
29	syphilis	30.5	CD79A CD40LG B2M ALB
30	fungal infectious disease	30.5	IL6 CARD9 ALB
31	polyneuropathy	30.5	NGF GDNF CD40LG ALB
32	radiculopathy	30.4	TAC1 IL6 CXCR3 CCL5
33	autoimmune disease	30.4	IL6 CXCR3 CD79A CD40LG CCL5 B2M
34	neutropenia	30.4	IL6 CD40LG C5AR1 ALB
35	acute kidney failure	30.3	IL6 B2M ALB
36	hemophagocytic lymphohistiocytosis	30.3	SH2D1A IL6 CCL5
37	psychotic disorder	30.3	NGF MECP2 IL6 BDNF APP
38	diarrhea	30.3	TAC1 IL6 CD40LG BDNF ALB
39	spondyloarthropathy 1	30.3	IL6 CD79A CD40LG
40	common variable immunodeficiency	30.3	SH2D1A IL6 CD79A CD40LG
41	trigeminal neuralgia	30.3	TAC1 NGF BDNF
42	pneumonia	30.3	IL6 CXCL2 CD40LG CCL5 C5AR1 ALB
43	mastitis	30.3	IL6 CCL5 ALB
44	common cold	30.3	IL6 CD40LG CCL5
45	demyelinating disease	30.3	NGF IL6 CCL5 BDNF
46	migraine with or without aura 1	30.2	TAC1 NGF IL6 BDNF ALB
47	aspiration pneumonia	30.2	TAC1 IL6 ALB
48	multiple sclerosis	30.2	NGF IL6 CXCR3 CD40LG CCL5 BDNF
49	pneumocystosis	30.2	IL6 CD40LG CARD9 ALB
50	relapsing-remitting multiple sclerosis	30.2	IL6 CXCR3 CCL5 BDNF

Graphical network of the top 20 diseases related to Meningoencephalitis:

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Symptoms & Phenotypes for Meningoencephalitis

GenomeRNAi Phenotypes related to Meningoencephalitis according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.19	ALB APP B2M BDNF C5 C5AR1
2	no effect	GR00402-S-2	10.19	ALB APP B2M BDNF C5 C5AR1

MGI Mouse Phenotypes related to Meningoencephalitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.27	ALB APP B2M BDNF C5 C5AR1
2	nervous system	MP:0003631	10.18	APP B2M BDNF C5 C5AR1 CD40LG
3	cellular	MP:0005384	10.1	ALB APP B2M BDNF C5AR1 CD40LG
4	normal	MP:0002873	10.09	ALB APP BDNF C5 CD79A CXCR3
5	cardiovascular system	MP:0005385	10.03	ALB APP B2M CD40LG CLDN5 CXCL2
6	immune system	MP:0005387	10.03	ALB APP B2M C5 C5AR1 CARD9
7	hematopoietic system	MP:0005397	9.73	APP B2M C5AR1 CARD9 CCL5 CD40LG
8	mortality/aging	MP:0010768	9.47	ALB APP B2M BDNF C5 C5AR1

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Drugs & Therapeutics for Meningoencephalitis

Drugs for Meningoencephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Amphotericin B

Approved, Investigational

Phase 2

1397-89-3

5280965

2

Fluconazole

Approved, Investigational

Phase 2

86386-73-4

3365

3

Tamoxifen

Approved

Phase 2

10540-29-1, 54965-24-1

2733526

4

Miconazole

Approved, Investigational, Vet_approved

Phase 2

22916-47-8

4189

5

Clotrimazole

Approved, Vet_approved

Phase 2

23593-75-1

2812

6

Amebicides

Phase 2

7

Anti-Bacterial Agents

Phase 2

8

Antineoplastic Agents, Hormonal

Phase 2

9

Estrogens

Phase 2

10

Anti-Infective Agents

Phase 2

11

Estrogen Receptor Modulators

Phase 2

12

Estrogen Receptor Antagonists

Phase 2

13

Estrogen Antagonists

Phase 2

14

Hormones

Phase 2

15

Antiprotozoal Agents

Phase 2

16

Antiparasitic Agents

Phase 2

17

Hormone Antagonists

Phase 2

18

Antifungal Agents

Phase 2

19

Liposomal amphotericin B

Phase 2

20

Cytochrome P-450 Enzyme Inhibitors

Phase 2

21

Selective Estrogen Receptor Modulators

Phase 2

22

Propranolol

Approved, Investigational

318-98-9, 525-66-6

62882 4946

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Randomized Trial of Tamoxifen Combined With Amphotericin B and Fluconazole for Cryptococcal Meningitis	Completed	NCT03112031	Phase 2	Tamoxifen;Amphotericin B;Fluconazole
2	Etiology of Orphan Community-based Meningitis and Meningo-encephalitis.	Unknown status	NCT02868593
3	Incidence and Severity of Neurocognitive Impairment in Pediatric Patients With Meningoencephalitis and Sepsis-associated Encephalopathy	Completed	NCT04467762
4	Integrating the Diagnosis and Management of HIV-associated Central Nervous System (CNS) Infections Into Routine Health Services in Low and Middle Income Countries (LMICs)	Completed	NCT03226379
5	Optimal Encephalitis/Meningitis Roadmap Via Precise Diagnosis and Treatment	Recruiting	NCT04946682
6	Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients	Terminated	NCT02207647
7	Prospective Investigation of Oxidative Stress in West Nile Virus Infection	Withdrawn	NCT04371003

Search NIH Clinical Center for Meningoencephalitis

Cochrane evidence based reviews: meningoencephalitis

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Genetic Tests for Meningoencephalitis

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Anatomical Context for Meningoencephalitis

Organs/tissues related to Meningoencephalitis:

MalaCards : Brain, Bone Marrow, T Cells, Temporal Lobe, Spinal Cord, Endothelial, Kidney

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Publications for Meningoencephalitis

Articles related to Meningoencephalitis:

(show top 50) (show all 7970)

#	Title	Authors	PMID	Year
1	HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele. ⁵³ ⁶²	Zota V...Monsonego A	19675171	2009
2	Abeta-induced meningoencephalitis is IFN-gamma-dependent and is associated with T cell-dependent clearance of Abeta in a mouse model of Alzheimer's disease. ⁵³ ⁶²	Monsonego A...Weiner HL	16549802	2006
3	Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease. ⁵³ ⁶²	Ferrer I...Costa-Jussa F	14997933	2004
4	Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice. ⁵³ ⁶²	Kennedy PG...Murray M	12805119	2003
5	No evidence for elevated numbers of mononuclear cells expressing MCP-1 and RANTES mRNA in blood and CSF in multiple sclerosis. ⁵³ ⁶²	Kivisakk P...Link H	9846826	1998
6	A substance P antagonist, RP-67,580, ameliorates a mouse meningoencephalitic response to Trypanosoma brucei brucei. ⁵³ ⁶²	Kennedy PG...Burke JM	9108123	1997
7	Antimyelin basic protein and antimyelin antibody-producing cells in multiple sclerosis. ⁵³ ⁶²	Olsson T...Link H	1690527	1990
8	Imaging of Central Nervous System Parasitic Infections. ⁶²	Vasconcelos Miranda TA...Lucato LT	36404040	2023
9	Mammaliicoccus (Staphylococcus) sciuri-induced suppurative meningoencephalitis and bacteremia in an infant western lowland gorilla (Gorilla gorilla gorilla). ⁶²	de Carvalho TP...Santos RL	35570384	2022
10	Comparative miRNA transcriptomics of macaques and mice reveals MYOC is an inhibitor for Cryptococcus neoformans invasion into the brain. ⁶²	Li H...Shang H	35621025	2022
11	Autopsy findings of COVID-19 in children: a systematic review and meta-analysis. ⁶²	Khairwa A...Jat KR	36048325	2022
12	Persistent HHV-6 DNAemia in a Patient Presenting With Meningoencephalitis. ⁶²	Sandhu A...Henrickson SE	36330748	2022
13	Meningoencephalitis following Le Fort I osteotomy: a case report. ⁶²	Goh R...Breik O	36055861	2022
14	An overview of micafungin as a treatment option for invasive candidiasis in pediatric patients younger than 4 months old. ⁶²	Bassetti M...Esposito S	36373395	2022
15	Elevated lumbar puncture opening pressure in aseptic meningitis. ⁶²	Ben-Dov M...Klein A	36265366	2022
16	Effect of benznidazole on cerebral microcirculation during acute Trypanosoma cruzi infection in mice. ⁶²	Gonzaga BMS...Garzoni LR	36473897	2022
17	Healthy adults with Streptococcus pneumoniae meningitis and Streptococcus pneumoniae subdural abscess: two case reports and a literature review. ⁶²	Kong F...Cao L	36396983	2022
18	Cerebrospinal fluid analysis in emergency patients with suspected infection of the central nervous system. ⁶²	Volk S...Klein M	36398479	2022
19	Dog leukocyte antigen class II alleles and haplotypes associated with meningoencephalomyelitis of unknown origin in Chihuahuas. ⁶²	Oshima A...Kitagawa M	36418080	2022
20	Epidemiology of Herpes Zoster in Adults in Mexico: A Retrospective Database Analysis. ⁶²	Guzman-Holst A...Huerta-Garcia G	36348227	2022
21	Autoimmune glial fibrillar acidic protein astrocytopathy mimicking tuberculous meningitis. ⁶²	Someko H...Shiojiri T	36400717	2022
22	Anti-astrocytic autoantibody patterns in the cerebrospinal fluid of patients with depression and psychosis. ⁶²	Endres D...Tebartz van Elst L	36265195	2022
23	Unraveling the Pathobiological Role of the Fungal KEOPS Complex in Cryptococcus neoformans. ⁶²	Choi Y...Bahn YS	36377896	2022
24	Clostridium septicum brain abscess. ⁶²	Tan DJA...Ling XW	36410787	2022
25	Virological, pathological, and glycovirological investigations of an Ezo red fox and a tanuki naturally infected with H5N1 high pathogenicity avian influenza viruses in Hokkaido, Japan. ⁶²	Hiono T...Sakoda Y	36462496	2022
26	Clinical Reasoning: A 12-Month-Old Male Child With Staring Episodes, Ataxia, and Right-sided Weakness. ⁶²	Brosius SN...McGuire J	36028321	2022
27	Autoimmune glial fibrillary acidic protein astrocytopathy masquerading as tuberculosis of the central nervous system: a case series. ⁶²	Quek AM...Seet RC	36162739	2022
28	Bruxism in awake dogs as a clinical sign of forebrain disease: 4 cases. ⁶²	Liatis T...Marioni-Henry K	36325625	2022
29	Chronic Enteroviral Meningoencephalitis in a Patient with Good's Syndrome Treated with Pocapavir. ⁶²	Grammatikos A...Gompels M	35870029	2022
30	First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil. ⁶²	de Oliveira RVM...Oliveira MME	36427702	2022
31	An autopsy case of autoimmune meningoencephalitis caused by pembrolizumab. ⁶²	Hiraoka Y...Tsushima T	36160065	2022
32	Recurrent Aseptic Meningoencephalitis Following BNT162b2 Vaccination for COVID-19. ⁶²	Kang K...Kim BK	36367072	2022
33	Pathogenesis and Preventive Tactics of Immune-Mediated Non-Pulmonary COVID-19 in Children and Beyond. ⁶²	Chi H...Yang KD	36430629	2022
34	Population pharmacokinetics of liposomal amphotericin B in adults with HIV-associated cryptococcal meningoencephalitis. ⁶²	Stott KE...Martson AG	36411251	2022
35	Role of cathepsin B of Naegleria fowleri during primary amebic meningoencephalitis. ⁶²	Rodriguez-Mera IB...Rojas-Hernandez S	36125528	2022
36	Surveillance of tick-borne encephalitis in emerging risk areas in southern Sweden: a retrospective case finding study. ⁶²	Waldeck M...Lindgren PE	36322256	2022
37	[Tick-Borne Encephalitis (TBE) - Clinical and Therapeutical Aspects]. ⁶²	Vlad B...Jelcic I	36303528	2022
38	Anti-NMDAR encephalitis with GFAPα IgG: a case report. ⁶²	Bai P...Zhen J	36371153	2022
39	Scrub Typhus Associated with Guillain-Barré Syndrome (GBS). ⁶²	Raghunathan V...Singhi S	35881216	2022
40	Mycophenolate mofetil and telmisartan for the treatment of proteinuria secondary to minimal change disease podocytopathy in a dog. ⁶²	Travail V...Di Bella A	36151875	2022
41	Fear of falling as a potential complication of Ramsay Hunt syndrome in older adults: a case report. ⁶²	Chou CC...Chang CM	36434527	2022
42	Distribution and Current State of Molecular Genetic Characterization in Pathogenic Free-Living Amoebae. ⁶²	Otero-Ruiz A...Lares-Villa F	36297255	2022
43	Resection of brain lesions with a neuroendoscopic ultrasonic aspirator - a systematic literature review. ⁶²	Ebel F...Soleman J	35896917	2022
44	Epstein-Barr virus meningoencephalitis in a young immunocompetent child: A case report. ⁶²	Pangprasertkul S...Sudjaritruk T	36299527	2022
45	Delayed Diagnosis of West Nile Meningoencephalitis in a Patient Receiving Rituximab for Rheumatoid Arthritis. ⁶²	Abdalla AA...Ateeli H	36381775	2022
46	Anthrax Meningoencephalitis and Intracranial Hemorrhage. ⁶²	Caffes N...Simard JM	36251558	2022
47	Survival of Patient With Hemorrhagic Meningitis Associated With Inhalation Anthrax. ⁶²	Lombarte Espinosa E...Rezusta A	36251557	2022
48	Cryptococcus neoformans Infection in the Central Nervous System: The Battle between Host and Pathogen. ⁶²	Chen Y...Shi M	36294634	2022
49	Meningoencephalitis in primary antibody deficiency: Our experience from northwest India. ⁶²	Jindal AK...Singh S	36030644	2022
50	Brain abscess caused by Listeria monocytogenes: a case report and literature review. ⁶²	Zhang C...Yi Z	35695050	2022

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Genes for Meningoencephalitis

Genes related to Meningoencephalitis (0 elite genes):

(show all 35)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	IL6	Interleukin 6	Protein Coding	14.17	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
2	ALB	Albumin	Protein Coding	14.05	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	CARD9	Caspase Recruitment Domain Family Member 9	Protein Coding	14.04	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
4	APP	Amyloid Beta Precursor Protein	Protein Coding	13.07	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	14997933 19675171
5	CXCR3	C-X-C Motif Chemokine Receptor 3	Protein Coding	12.6	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
6	CD40LG	CD40 Ligand	Protein Coding	12.43	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
7	CXCL2	C-X-C Motif Chemokine Ligand 2	Protein Coding	12.22	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
8	NGF	Nerve Growth Factor	Protein Coding	11.93	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
9	CLDN5	Claudin 5	Protein Coding	11.86	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
10	B2M	Beta-2-Microglobulin	Protein Coding	11.76	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
11	CD79A	CD79a Molecule	Protein Coding	11.76	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
12	C5AR1	Complement C5a Receptor 1	Protein Coding	11.74	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
13	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	11.62	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
14	TAC1	Tachykinin Precursor 1	Protein Coding	11.2	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
15	SH2D1A	SH2 Domain Containing 1A	Protein Coding	11.03	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
16	GDNF	Glial Cell Derived Neurotrophic Factor	Protein Coding	11.01	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
17	C5	Complement C5	Protein Coding	10.27	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
18	TACR3	Tachykinin Receptor 3	Protein Coding	10.23	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
19	MECP2	Methyl-CpG Binding Protein 2	Protein Coding	10.17	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
20	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	9.49	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	18239321 9846826
21	MBP	Myelin Basic Protein	Protein Coding	9.02	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	1690527 16549802
22	SERPINA3	Serpin Family A Member 3	Protein Coding	7.55	DISEASES inferred ¹⁴ ¹⁴
23	CD4	CD4 Molecule	Protein Coding	7.28	DISEASES inferred ¹⁴
24	TNPO1	Transportin 1	Protein Coding	7.25	GeneCards inferred via : Publications (show sections)
25	CD8A	CD8a Molecule	Protein Coding	6.89	DISEASES inferred ¹⁴
26	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	6.88	DISEASES inferred ¹⁴ ¹⁴
27	CRP	C-Reactive Protein	Protein Coding	6.73	DISEASES inferred ¹⁴
28	TNF	Tumor Necrosis Factor	Protein Coding	6.57	DISEASES inferred ¹⁴
29	IL10	Interleukin 10	Protein Coding	6.44	DISEASES inferred ¹⁴
30	EPRS1	Glutamyl-Prolyl-TRNA Synthetase 1	Protein Coding	6.43	DISEASES inferred ¹⁴ ¹⁴
31	MOG	Myelin Oligodendrocyte Glycoprotein	Protein Coding	6.41	DISEASES inferred ¹⁴
32	IL1B	Interleukin 1 Beta	Protein Coding	6.35	DISEASES inferred ¹⁴
33	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	6.3	DISEASES inferred ¹⁴
34	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	6.26	DISEASES inferred ¹⁴
35	PLB1	Phospholipase B1	Protein Coding	6.26	DISEASES inferred ¹⁴

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Variations for Meningoencephalitis

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Expression for Meningoencephalitis

Search GEO for disease gene expression data for Meningoencephalitis.

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Pathways for Meningoencephalitis

Pathways related to Meningoencephalitis according to GeneCards Suite gene sharing:

(show all 22)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.77	APP B2M C5 C5AR1 CARD9 CCL5
2	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.51	NGF IL6 GDNF CXCR3 CXCL2 CD40LG
3	GPCR downstream signalling ⁶⁶ Show member pathways G alpha (i) signalling events ⁶⁶ G alpha (q) signalling events ⁶⁶ Signaling by GPCR ⁶⁶	13.45	TACR3 TAC1 CXCR3 CXCL2 CCL5 C5AR1
4	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.28	NGF IL6 CXCR3 CXCL2 CD40LG CCL5
5	Class A/1 (Rhodopsin-like receptors) ⁶⁶ Show member pathways GPCR ligand binding ⁶⁶ GPCRs, class A rhodopsin-like ⁷⁴ Peptide GPCRs ⁷⁴ Peptide ligand-binding receptors ⁶⁶	13.16	TACR3 TAC1 CXCR3 CXCL2 CCL5 C5AR1
6	Signal Transduction ⁶⁶	13.15	TACR3 TAC1 NGF IL6 GDNF CXCR3
7	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.13	NGF IL6 CXCR3 CXCL2 CD40LG CCL5
8	NF-kappaB Signaling ³	12.15	SH2D1A CD79A CD40LG CCL5 CARD9 B2M
9	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	11.92	BDNF IL6 MECP2 NGF TAC1
10	Allograft rejection ⁷⁴	11.75	GDNF CD40LG C5
11	Neural Stem Cells and Lineage-specific Markers ⁶⁵	11.66	NGF GDNF BDNF
12	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.59	CD40LG CD79A IL6
13	p75(NTR)-mediated signaling ⁶¹ Show member pathways Ceramide signalling ⁶⁶ NFG and proNGF binds to p75NTR ⁶⁶	11.55	NGF BDNF APP
14	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.52	IL6 CXCL2 CD40LG
15	Prader-Willi and Angelman syndrome ⁷⁴	11.49	TACR3 NGF BDNF
16	Lung fibrosis ⁷⁴	11.47	MECP2 IL6 CXCL2 CCL5
17	SHP2 signaling ⁶¹	11.42	NGF IL6 BDNF
18	Neurogenesis regulation in the olfactory epithelium ⁷⁴	11.31	NGF MECP2 BDNF APP
19	Interleukin-10 signaling ⁶⁶	11.3	IL6 CXCL2 CCL5
20	Spinal cord injury ⁷⁴	11.08	IL6 GDNF CXCL2 C5 BDNF
21	G-protein signaling_Rap2B regulation pathway ²²	10.78	NGF IL6 CXCL2 CD40LG CCL5 BDNF
22	Tachykinin receptors bind tachykinins ⁶⁶	10.19	TACR3 TAC1

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GO Terms for Meningoencephalitis

Cellular components related to Meningoencephalitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10.02	TAC1 NGF IL6 GDNF CXCL2 CD40LG
2	extracellular space	GO:0005615	9.74	ALB APP B2M BDNF C5 CCL5

Biological processes related to Meningoencephalitis according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of neuron apoptotic process	GO:0043524	10.11	NGF MECP2 GDNF BDNF
2	neuron projection development	GO:0031175	10.02	MECP2 IL6 GDNF APP
3	chemotaxis	GO:0006935	10.02	C5 C5AR1 CCL5 CXCL2 CXCR3
4	positive regulation of peptidyl-serine phosphorylation	GO:0033138	10.01	NGF IL6 BDNF APP
5	peripheral nervous system development	GO:0007422	9.93	NGF GDNF BDNF
6	positive regulation of vascular endothelial growth factor production	GO:0010575	9.91	C5 C5AR1 IL6
7	positive regulation of chemokine production	GO:0032722	9.86	IL6 CARD9 C5 APP
8	cell chemotaxis	GO:0060326	9.85	CXCR3 CXCL2 CCL5 C5
9	positive regulation of receptor binding	GO:1900122	9.8	BDNF B2M
10	immune response	GO:0006955	9.65	B2M C5 C5AR1 CCL5 CD40LG CXCL2
11	response to peptidoglycan	GO:0032494	9.63	IL6 CARD9 C5AR1
12	inflammatory response	GO:0006954	9.53	TAC1 IL6 CXCR3 CXCL2 CD40LG CCL5

Molecular functions related to Meningoencephalitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:0008009	9.63	CXCL2 CCL5 C5
2	signaling receptor binding	GO:0005102	9.32	NGF IL6 GDNF CD40LG C5 BDNF
3	nerve growth factor receptor binding	GO:0005163	9.26	NGF BDNF

Sources

Sources for Meningoencephalitis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: MNN009 MIFTS: 48	Meningoencephalitis Categories: Infectious diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
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