MCID: MNN009
MIFTS: 48

Meningoencephalitis

Categories: Infectious diseases, Neuronal diseases
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Aliases & Classifications for Meningoencephalitis

MalaCards integrated aliases for Meningoencephalitis:

Name: Meningoencephalitis 11 53 43 14 16 71 75
Meningoencephalitis Due to Acquired Toxoplasmosis 33
Acquired Toxoplasmal Meningoencephalitis 33
Meningoencephalitis Due to Toxoplasmosis 33
Toxoplasma Meningoencephalitis 33

Classifications:



External Ids:

Disease Ontology 11 DOID:10554
MeSH 43 D008590
NCIt 49 C34813
SNOMED-CT 68 7125002
ICD11 33 540652293
UMLS 71 C0025309

Summaries for Meningoencephalitis

Disease Ontology: 11 A central nervous system disease that involves encephalitis which occurs along with meningitis.

MalaCards based summary: Meningoencephalitis, also known as meningoencephalitis due to acquired toxoplasmosis, is related to meningitis and toxoplasmosis. An important gene associated with Meningoencephalitis is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Amphotericin B and Fluconazole have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and t cells, and related phenotypes are homeostasis/metabolism and nervous system

Wikipedia: 75 Meningoencephalitis (/mɪˌnɪŋɡoʊɛnˌsɛfəˈlaɪtɪs, -ˌnɪndʒoʊ-, -ən-, -ˌkɛ-/; from Ancient Greek: μῆνιγξ,... more...

Related Diseases for Meningoencephalitis

Diseases related to Meningoencephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 898)
# Related Disease Score Top Affiliating Genes
1 meningitis 32.1 IL6 GDNF CXCL2 CCL5 ALB
2 toxoplasmosis 31.3 IL6 CD79A CD40LG
3 acquired immunodeficiency syndrome 31.1 IL6 CD79A CD40LG B2M ALB
4 vasculitis 31.1 SH2D1A IL6 CD79A CD40LG
5 hydrocephalus 31.1 NGF GDNF BDNF APP
6 agammaglobulinemia 31.0 SH2D1A IL6 CD79A CD40LG
7 viral infectious disease 31.0 IL6 CXCR3 CD40LG CCL5 B2M
8 myocarditis 30.9 IL6 CD40LG CCL5 ALB
9 optic neuritis 30.9 IL6 CXCR3 BDNF
10 brain edema 30.9 IL6 CLDN5 ALB
11 neuritis 30.8 IL6 GDNF CCL5 BDNF
12 endophthalmitis 30.8 IL6 CARD9 ALB
13 respiratory failure 30.8 TAC1 IL6 CCL5 ALB
14 central nervous system disease 30.8 NGF CXCR3 BDNF APP
15 viral meningitis 30.7 IL6 CXCR3 CCL5 B2M ALB
16 pleural empyema 30.7 IL6 CD79A ALB
17 otitis media 30.7 IL6 CD79A CD40LG CCL5 ALB
18 guillain-barre syndrome 30.6 CD79A CD40LG ALB
19 immune deficiency disease 30.6 SH2D1A IL6 CXCR3 CD79A CD40LG CCL5
20 rabies 30.6 CD40LG CCL5 ALB
21 trypanosomiasis 30.6 IL6 CXCR3 ALB
22 peritonitis 30.6 IL6 CXCL2 B2M ALB
23 candidiasis 30.5 SH2D1A IL6 CARD9
24 dengue disease 30.5 IL6 CD40LG CCL5 ALB
25 sarcoidosis 1 30.5 TAC1 IL6 CXCR3 CCL5 ALB
26 alcohol use disorder 30.5 IL6 BDNF ALB
27 cerebritis 30.5 IL6 ALB
28 amebiasis 30.5 IL6 CD79A ALB
29 syphilis 30.5 CD79A CD40LG B2M ALB
30 fungal infectious disease 30.5 IL6 CARD9 ALB
31 polyneuropathy 30.5 NGF GDNF CD40LG ALB
32 radiculopathy 30.4 TAC1 IL6 CXCR3 CCL5
33 autoimmune disease 30.4 IL6 CXCR3 CD79A CD40LG CCL5 B2M
34 neutropenia 30.4 IL6 CD40LG C5AR1 ALB
35 acute kidney failure 30.3 IL6 B2M ALB
36 hemophagocytic lymphohistiocytosis 30.3 SH2D1A IL6 CCL5
37 psychotic disorder 30.3 NGF MECP2 IL6 BDNF APP
38 diarrhea 30.3 TAC1 IL6 CD40LG BDNF ALB
39 spondyloarthropathy 1 30.3 IL6 CD79A CD40LG
40 common variable immunodeficiency 30.3 SH2D1A IL6 CD79A CD40LG
41 trigeminal neuralgia 30.3 TAC1 NGF BDNF
42 pneumonia 30.3 IL6 CXCL2 CD40LG CCL5 C5AR1 ALB
43 mastitis 30.3 IL6 CCL5 ALB
44 common cold 30.3 IL6 CD40LG CCL5
45 demyelinating disease 30.3 NGF IL6 CCL5 BDNF
46 migraine with or without aura 1 30.2 TAC1 NGF IL6 BDNF ALB
47 aspiration pneumonia 30.2 TAC1 IL6 ALB
48 multiple sclerosis 30.2 NGF IL6 CXCR3 CD40LG CCL5 BDNF
49 pneumocystosis 30.2 IL6 CD40LG CARD9 ALB
50 relapsing-remitting multiple sclerosis 30.2 IL6 CXCR3 CCL5 BDNF

Graphical network of the top 20 diseases related to Meningoencephalitis:



Diseases related to Meningoencephalitis

Symptoms & Phenotypes for Meningoencephalitis

GenomeRNAi Phenotypes related to Meningoencephalitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.19 ALB APP B2M BDNF C5 C5AR1
2 no effect GR00402-S-2 10.19 ALB APP B2M BDNF C5 C5AR1

MGI Mouse Phenotypes related to Meningoencephalitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.27 ALB APP B2M BDNF C5 C5AR1
2 nervous system MP:0003631 10.18 APP B2M BDNF C5 C5AR1 CD40LG
3 cellular MP:0005384 10.1 ALB APP B2M BDNF C5AR1 CD40LG
4 normal MP:0002873 10.09 ALB APP BDNF C5 CD79A CXCR3
5 cardiovascular system MP:0005385 10.03 ALB APP B2M CD40LG CLDN5 CXCL2
6 immune system MP:0005387 10.03 ALB APP B2M C5 C5AR1 CARD9
7 hematopoietic system MP:0005397 9.73 APP B2M C5AR1 CARD9 CCL5 CD40LG
8 mortality/aging MP:0010768 9.47 ALB APP B2M BDNF C5 C5AR1

Drugs & Therapeutics for Meningoencephalitis

Drugs for Meningoencephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amphotericin B Approved, Investigational Phase 2 1397-89-3 5280965
2
Fluconazole Approved, Investigational Phase 2 86386-73-4 3365
3
Tamoxifen Approved Phase 2 10540-29-1, 54965-24-1 2733526
4
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
5
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
6 Amebicides Phase 2
7 Anti-Bacterial Agents Phase 2
8 Antineoplastic Agents, Hormonal Phase 2
9 Estrogens Phase 2
10 Anti-Infective Agents Phase 2
11 Estrogen Receptor Modulators Phase 2
12 Estrogen Receptor Antagonists Phase 2
13 Estrogen Antagonists Phase 2
14 Hormones Phase 2
15 Antiprotozoal Agents Phase 2
16 Antiparasitic Agents Phase 2
17 Hormone Antagonists Phase 2
18 Antifungal Agents Phase 2
19 Liposomal amphotericin B Phase 2
20 Cytochrome P-450 Enzyme Inhibitors Phase 2
21 Selective Estrogen Receptor Modulators Phase 2
22
Propranolol Approved, Investigational 318-98-9, 525-66-6 62882 4946

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Trial of Tamoxifen Combined With Amphotericin B and Fluconazole for Cryptococcal Meningitis Completed NCT03112031 Phase 2 Tamoxifen;Amphotericin B;Fluconazole
2 Etiology of Orphan Community-based Meningitis and Meningo-encephalitis. Unknown status NCT02868593
3 Incidence and Severity of Neurocognitive Impairment in Pediatric Patients With Meningoencephalitis and Sepsis-associated Encephalopathy Completed NCT04467762
4 Integrating the Diagnosis and Management of HIV-associated Central Nervous System (CNS) Infections Into Routine Health Services in Low and Middle Income Countries (LMICs) Completed NCT03226379
5 Optimal Encephalitis/Meningitis Roadmap Via Precise Diagnosis and Treatment Recruiting NCT04946682
6 Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients Terminated NCT02207647
7 Prospective Investigation of Oxidative Stress in West Nile Virus Infection Withdrawn NCT04371003

Search NIH Clinical Center for Meningoencephalitis

Cochrane evidence based reviews: meningoencephalitis

Genetic Tests for Meningoencephalitis

Anatomical Context for Meningoencephalitis

Organs/tissues related to Meningoencephalitis:

MalaCards : Brain, Bone Marrow, T Cells, Temporal Lobe, Spinal Cord, Endothelial, Kidney

Publications for Meningoencephalitis

Articles related to Meningoencephalitis:

(show top 50) (show all 7970)
# Title Authors PMID Year
1
HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele. 53 62
19675171 2009
2
Abeta-induced meningoencephalitis is IFN-gamma-dependent and is associated with T cell-dependent clearance of Abeta in a mouse model of Alzheimer's disease. 53 62
16549802 2006
3
Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease. 53 62
14997933 2004
4
Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice. 53 62
12805119 2003
5
No evidence for elevated numbers of mononuclear cells expressing MCP-1 and RANTES mRNA in blood and CSF in multiple sclerosis. 53 62
9846826 1998
6
A substance P antagonist, RP-67,580, ameliorates a mouse meningoencephalitic response to Trypanosoma brucei brucei. 53 62
9108123 1997
7
Antimyelin basic protein and antimyelin antibody-producing cells in multiple sclerosis. 53 62
1690527 1990
8
Imaging of Central Nervous System Parasitic Infections. 62
36404040 2023
9
Mammaliicoccus (Staphylococcus) sciuri-induced suppurative meningoencephalitis and bacteremia in an infant western lowland gorilla (Gorilla gorilla gorilla). 62
35570384 2022
10
Comparative miRNA transcriptomics of macaques and mice reveals MYOC is an inhibitor for Cryptococcus neoformans invasion into the brain. 62
35621025 2022
11
Autopsy findings of COVID-19 in children: a systematic review and meta-analysis. 62
36048325 2022
12
Persistent HHV-6 DNAemia in a Patient Presenting With Meningoencephalitis. 62
36330748 2022
13
Meningoencephalitis following Le Fort I osteotomy: a case report. 62
36055861 2022
14
An overview of micafungin as a treatment option for invasive candidiasis in pediatric patients younger than 4 months old. 62
36373395 2022
15
Elevated lumbar puncture opening pressure in aseptic meningitis. 62
36265366 2022
16
Effect of benznidazole on cerebral microcirculation during acute Trypanosoma cruzi infection in mice. 62
36473897 2022
17
Healthy adults with Streptococcus pneumoniae meningitis and Streptococcus pneumoniae subdural abscess: two case reports and a literature review. 62
36396983 2022
18
Cerebrospinal fluid analysis in emergency patients with suspected infection of the central nervous system. 62
36398479 2022
19
Dog leukocyte antigen class II alleles and haplotypes associated with meningoencephalomyelitis of unknown origin in Chihuahuas. 62
36418080 2022
20
Epidemiology of Herpes Zoster in Adults in Mexico: A Retrospective Database Analysis. 62
36348227 2022
21
Autoimmune glial fibrillar acidic protein astrocytopathy mimicking tuberculous meningitis. 62
36400717 2022
22
Anti-astrocytic autoantibody patterns in the cerebrospinal fluid of patients with depression and psychosis. 62
36265195 2022
23
Unraveling the Pathobiological Role of the Fungal KEOPS Complex in Cryptococcus neoformans. 62
36377896 2022
24
Clostridium septicum brain abscess. 62
36410787 2022
25
Virological, pathological, and glycovirological investigations of an Ezo red fox and a tanuki naturally infected with H5N1 high pathogenicity avian influenza viruses in Hokkaido, Japan. 62
36462496 2022
26
Clinical Reasoning: A 12-Month-Old Male Child With Staring Episodes, Ataxia, and Right-sided Weakness. 62
36028321 2022
27
Autoimmune glial fibrillary acidic protein astrocytopathy masquerading as tuberculosis of the central nervous system: a case series. 62
36162739 2022
28
Bruxism in awake dogs as a clinical sign of forebrain disease: 4 cases. 62
36325625 2022
29
Chronic Enteroviral Meningoencephalitis in a Patient with Good's Syndrome Treated with Pocapavir. 62
35870029 2022
30
First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil. 62
36427702 2022
31
An autopsy case of autoimmune meningoencephalitis caused by pembrolizumab. 62
36160065 2022
32
Recurrent Aseptic Meningoencephalitis Following BNT162b2 Vaccination for COVID-19. 62
36367072 2022
33
Pathogenesis and Preventive Tactics of Immune-Mediated Non-Pulmonary COVID-19 in Children and Beyond. 62
36430629 2022
34
Population pharmacokinetics of liposomal amphotericin B in adults with HIV-associated cryptococcal meningoencephalitis. 62
36411251 2022
35
Role of cathepsin B of Naegleria fowleri during primary amebic meningoencephalitis. 62
36125528 2022
36
Surveillance of tick-borne encephalitis in emerging risk areas in southern Sweden: a retrospective case finding study. 62
36322256 2022
37
[Tick-Borne Encephalitis (TBE) - Clinical and Therapeutical Aspects]. 62
36303528 2022
38
Anti-NMDAR encephalitis with GFAPα IgG: a case report. 62
36371153 2022
39
Scrub Typhus Associated with Guillain-Barré Syndrome (GBS). 62
35881216 2022
40
Mycophenolate mofetil and telmisartan for the treatment of proteinuria secondary to minimal change disease podocytopathy in a dog. 62
36151875 2022
41
Fear of falling as a potential complication of Ramsay Hunt syndrome in older adults: a case report. 62
36434527 2022
42
Distribution and Current State of Molecular Genetic Characterization in Pathogenic Free-Living Amoebae. 62
36297255 2022
43
Resection of brain lesions with a neuroendoscopic ultrasonic aspirator - a systematic literature review. 62
35896917 2022
44
Epstein-Barr virus meningoencephalitis in a young immunocompetent child: A case report. 62
36299527 2022
45
Delayed Diagnosis of West Nile Meningoencephalitis in a Patient Receiving Rituximab for Rheumatoid Arthritis. 62
36381775 2022
46
Anthrax Meningoencephalitis and Intracranial Hemorrhage. 62
36251558 2022
47
Survival of Patient With Hemorrhagic Meningitis Associated With Inhalation Anthrax. 62
36251557 2022
48
Cryptococcus neoformans Infection in the Central Nervous System: The Battle between Host and Pathogen. 62
36294634 2022
49
Meningoencephalitis in primary antibody deficiency: Our experience from northwest India. 62
36030644 2022
50
Brain abscess caused by Listeria monocytogenes: a case report and literature review. 62
35695050 2022

Variations for Meningoencephalitis

Expression for Meningoencephalitis

Search GEO for disease gene expression data for Meningoencephalitis.

Pathways for Meningoencephalitis

Pathways related to Meningoencephalitis according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 APP B2M C5 C5AR1 CARD9 CCL5
2
Show member pathways
13.51 NGF IL6 GDNF CXCR3 CXCL2 CD40LG
3
Show member pathways
13.45 TACR3 TAC1 CXCR3 CXCL2 CCL5 C5AR1
4
Show member pathways
13.28 NGF IL6 CXCR3 CXCL2 CD40LG CCL5
5
Show member pathways
13.16 TACR3 TAC1 CXCR3 CXCL2 CCL5 C5AR1
6 13.15 TACR3 TAC1 NGF IL6 GDNF CXCR3
7
Show member pathways
13.13 NGF IL6 CXCR3 CXCL2 CD40LG CCL5
8 12.15 SH2D1A CD79A CD40LG CCL5 CARD9 B2M
9 11.92 BDNF IL6 MECP2 NGF TAC1
10 11.75 GDNF CD40LG C5
11 11.66 NGF GDNF BDNF
12 11.59 CD40LG CD79A IL6
13
Show member pathways
11.55 NGF BDNF APP
14
Show member pathways
11.52 IL6 CXCL2 CD40LG
15 11.49 TACR3 NGF BDNF
16 11.47 MECP2 IL6 CXCL2 CCL5
17 11.42 NGF IL6 BDNF
18 11.31 NGF MECP2 BDNF APP
19 11.3 IL6 CXCL2 CCL5
20 11.08 IL6 GDNF CXCL2 C5 BDNF
21 10.78 NGF IL6 CXCL2 CD40LG CCL5 BDNF
22 10.19 TACR3 TAC1

GO Terms for Meningoencephalitis

Cellular components related to Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.02 TAC1 NGF IL6 GDNF CXCL2 CD40LG
2 extracellular space GO:0005615 9.74 ALB APP B2M BDNF C5 CCL5

Biological processes related to Meningoencephalitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 10.11 NGF MECP2 GDNF BDNF
2 neuron projection development GO:0031175 10.02 MECP2 IL6 GDNF APP
3 chemotaxis GO:0006935 10.02 C5 C5AR1 CCL5 CXCL2 CXCR3
4 positive regulation of peptidyl-serine phosphorylation GO:0033138 10.01 NGF IL6 BDNF APP
5 peripheral nervous system development GO:0007422 9.93 NGF GDNF BDNF
6 positive regulation of vascular endothelial growth factor production GO:0010575 9.91 C5 C5AR1 IL6
7 positive regulation of chemokine production GO:0032722 9.86 IL6 CARD9 C5 APP
8 cell chemotaxis GO:0060326 9.85 CXCR3 CXCL2 CCL5 C5
9 positive regulation of receptor binding GO:1900122 9.8 BDNF B2M
10 immune response GO:0006955 9.65 B2M C5 C5AR1 CCL5 CD40LG CXCL2
11 response to peptidoglycan GO:0032494 9.63 IL6 CARD9 C5AR1
12 inflammatory response GO:0006954 9.53 TAC1 IL6 CXCR3 CXCL2 CD40LG CCL5

Molecular functions related to Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.63 CXCL2 CCL5 C5
2 signaling receptor binding GO:0005102 9.32 NGF IL6 GDNF CD40LG C5 BDNF
3 nerve growth factor receptor binding GO:0005163 9.26 NGF BDNF

Sources for Meningoencephalitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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