MCID: MNN009
MIFTS: 48

Meningoencephalitis

Categories: Neuronal diseases

Aliases & Classifications for Meningoencephalitis

MalaCards integrated aliases for Meningoencephalitis:

Name: Meningoencephalitis 12 54 44 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10554
MeSH 44 D008590
NCIt 50 C34813
SNOMED-CT 67 7125002
ICD10 32 A69.22
UMLS 71 C0025309

Summaries for Meningoencephalitis

Disease Ontology : 12 A central nervous system disease that involves encephalitis which occurs along with meningitis.

MalaCards based summary : Meningoencephalitis is related to meningitis and toxoplasmosis. An important gene associated with Meningoencephalitis is ALB (Albumin), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Immunologic Factors and gamma-Globulins have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and kidney, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 74 Meningoencephalitis (/mɪˌnɪŋɡoʊɛnˌsɛfəˈlaɪtɪs, -ˌnɪndʒoʊ-, -ən-, -ˌkɛ-/; from Greek μῆνιγξ meninx,... more...

Related Diseases for Meningoencephalitis

Diseases related to Meningoencephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 933)
# Related Disease Score Top Affiliating Genes
1 meningitis 31.3 IL6 GDNF CXCL2 CCL5 ALB
2 toxoplasmosis 31.2 IL6 CD79A CD40LG
3 vasculitis 31.1 SERPINA3 IL6 CD79A CD40LG
4 chickenpox 31.0 IL6 CD4 CCR6 ALB
5 parotitis 31.0 CD79A CD4 ALB
6 listeriosis 30.9 IL6 CD4 CCR6
7 cryptococcosis 30.9 CD4 CCR6 CARD9
8 brain edema 30.8 IL6 CLDN5 ALB
9 exanthem 30.8 IL6 CD4 CCR6 ALB
10 endophthalmitis 30.8 IL6 CARD9 ALB
11 optic neuritis 30.7 MBP IL6 BDNF
12 hydrocephalus 30.7 SERPINA3 NGF MBP GDNF BDNF APP
13 myelitis 30.7 MBP IL6 CCR6
14 peritonitis 30.6 IL6 CXCL2 B2M ALB
15 guillain-barre syndrome 30.6 MBP CD79A ALB
16 rabies 30.5 CD40LG CCL5 ALB
17 pleural empyema 30.5 IL6 CD79A CD4 ALB
18 papilledema 30.5 SERPINA3 CD4 ALB
19 agammaglobulinemia, x-linked 30.4 CD79A CD40LG CD4 CCR6
20 neuritis 30.4 MBP IL6 GDNF CXCL2 CCL5 BDNF
21 coccidioidomycosis 30.4 CD4 CCR6 CARD9
22 typhoid fever 30.4 IL6 CCR6 ALB
23 trigeminal neuralgia 30.4 TAC1 NGF BDNF
24 cerebritis 30.3 CXCL2 CD4 C5AR1
25 disease by infectious agent 30.3 SERPINA3 IL6 CD4 CCR6 ALB
26 neuromyelitis optica 30.3 MBP IL6 CD40LG
27 diarrhea 30.3 TAC1 IL6 CD40LG ALB
28 transverse myelitis 30.3 MBP IL6 CCR6
29 viral encephalitis 30.3 MBP IL6 CD4 CCR6 CCL5
30 chronic graft versus host disease 30.3 CD79A CCL5
31 migraine with or without aura 1 30.2 TAC1 NGF IL6 BDNF ALB
32 tetanus 30.2 IL6 GDNF CD79A CD40LG ALB
33 bronchopneumonia 30.2 SERPINA3 IL6 CD4 ALB
34 pneumonia 30.2 IL6 CXCL2 CD40LG CCL5 C5AR1 ALB
35 encephalomalacia 30.1 MBP IL6 BDNF
36 bacterial infectious disease 30.1 SERPINA3 IL6 CXCL2 CD4 CCR6
37 polyneuropathy 30.1 NGF MBP IL6 GDNF CD40LG ALB
38 epidural abscess 30.1 CD4 ALB
39 acquired immunodeficiency syndrome 30.1 MBP IL6 CD79A CD40LG CD4 CCR6
40 decubitus ulcer 30.1 NGF IL6 ALB
41 agnosia 30.1 TAC1 NGF IL6 BDNF ALB
42 communicating hydrocephalus 30.1 SERPINA3 APP ALB
43 aspiration pneumonia 30.1 TAC1 SERPINA3 IL6 ALB
44 normal pressure hydrocephalus 30.1 SERPINA3 NGF BDNF APP
45 mastitis 30.1 IL6 CCL5 ALB
46 crohn's disease 30.0 IL6 CD4 CCR6 CARD9 ALB
47 neuropathy 30.0 NGF MBP IL6 GDNF BDNF ALB
48 progressive multifocal leukoencephalopathy 30.0 MBP CD40LG CD4 CCR6
49 mucormycosis 30.0 CD4 CCR6 CARD9 ALB
50 autoimmune disease 30.0 MBP IL6 CD79A CD40LG CCR6 CCL5

Graphical network of the top 20 diseases related to Meningoencephalitis:



Diseases related to Meningoencephalitis

Symptoms & Phenotypes for Meningoencephalitis

MGI Mouse Phenotypes related to Meningoencephalitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.2 ALB APP B2M BDNF C5AR1 CARD9
2 hematopoietic system MP:0005397 10.18 APP B2M C5AR1 CARD9 CCL5 CCR6
3 immune system MP:0005387 10.1 ALB APP B2M C5AR1 CARD9 CCL5
4 integument MP:0010771 9.81 APP B2M BDNF CD4 CD40LG IL6
5 nervous system MP:0003631 9.77 APP B2M BDNF C5AR1 CCR6 CD4
6 normal MP:0002873 9.28 ALB APP BDNF CCR6 CD4 CD79A

Drugs & Therapeutics for Meningoencephalitis

Drugs for Meningoencephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 3
2 gamma-Globulins Phase 3
3 Immunoglobulins Phase 3
4 Antibodies Phase 3
5 Immunoglobulins, Intravenous Phase 3
6 Rho(D) Immune Globulin Phase 3
7
Fluconazole Approved, Investigational Phase 2 86386-73-4 3365
8
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
9
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
10
Amphotericin B Approved, Investigational Phase 2 1397-89-3 14956 5280965
11
Tamoxifen Approved Phase 2 10540-29-1 2733526
12 Antifungal Agents Phase 2
13 Hormone Antagonists Phase 2
14 Cytochrome P-450 Enzyme Inhibitors Phase 2
15 Estrogens Phase 2
16 Estrogen Antagonists Phase 2
17 Hormones Phase 2
18 Amebicides Phase 2
19 Estrogen Receptor Modulators Phase 2
20 Estrogen Receptor Antagonists Phase 2
21 Liposomal amphotericin B Phase 2
22 Anti-Infective Agents Phase 2
23 Antiparasitic Agents Phase 2
24 Antiprotozoal Agents Phase 2
25 Anti-Bacterial Agents Phase 2
26 Antineoplastic Agents, Hormonal Phase 2
27
Propranolol Approved, Investigational 525-66-6 4946

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase III Multi-centre Randomised, Double Blind, Placebo Controlled Trial to Assess the Role of Intravenous Immunoglobulin in the Management of Children With Encephalitis Unknown status NCT02308982 Phase 3 Immunoglobulins, Intravenous (Privigen);Placebo
2 A Randomized Trial of Tamoxifen Combined With Amphotericin B and Fluconazole for Cryptococcal Meningitis Completed NCT03112031 Phase 2 Tamoxifen;Amphotericin B;Fluconazole
3 Etiology of Orphan Community-based Meningitis and Meningo-encephalitis. Unknown status NCT02868593
4 Integrating the Diagnosis and Management of HIV-associated Central Nervous System (CNS) Infections Into Routine Health Services in Low and Middle Income Countries (LMICs) Recruiting NCT03226379
5 Incidence and Severity of Neurocognitive Impairment in Pediatric Patients With Meningoencephalitis and Sepsis-associated Encephalopathy Recruiting NCT04467762
6 Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients Active, not recruiting NCT02207647
7 Prospective Investigation of Oxidative Stress in West Nile Virus Infection Withdrawn NCT04371003

Search NIH Clinical Center for Meningoencephalitis

Cochrane evidence based reviews: meningoencephalitis

Genetic Tests for Meningoencephalitis

Anatomical Context for Meningoencephalitis

MalaCards organs/tissues related to Meningoencephalitis:

40
Brain, Endothelial, Kidney, T Cells, Pituitary, Bone Marrow, Skin

Publications for Meningoencephalitis

Articles related to Meningoencephalitis:

(show top 50) (show all 7312)
# Title Authors PMID Year
1
HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele. 61 54
19675171 2009
2
Abeta-induced meningoencephalitis is IFN-gamma-dependent and is associated with T cell-dependent clearance of Abeta in a mouse model of Alzheimer's disease. 61 54
16549802 2006
3
Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease. 54 61
14997933 2004
4
Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice. 54 61
12805119 2003
5
No evidence for elevated numbers of mononuclear cells expressing MCP-1 and RANTES mRNA in blood and CSF in multiple sclerosis. 54 61
9846826 1998
6
A substance P antagonist, RP-67,580, ameliorates a mouse meningoencephalitic response to Trypanosoma brucei brucei. 54 61
9108123 1997
7
Antimyelin basic protein and antimyelin antibody-producing cells in multiple sclerosis. 61 54
1690527 1990
8
Unexpected case of cryptococcal meningoencephalitis in a patient with long-standing well-controlled HIV infection. 61
33552883 2021
9
Cryptococcal meningoencephalitis in a multiple sclerosis patient after fingolimod discontinuation-a case report. 61
32968870 2021
10
Low Virus-Specific IgG Antibodies in Adverse Clinical Course and Outcome of Tick-Borne Encephalitis. 61
33562267 2021
11
A Search for Anti-Naegleria fowleri Agents Based on Competitive Exclusion Behavior of Microorganisms in Natural Aquatic Environments. 61
33535404 2021
12
REACTIVATION VARICELLA ZOSTER MENINGOENCEPHALITIS AND SINUSITIS IN A SEEMINGLY IMMUNOCOMPETENT ADOLESCENT. 61
33600627 2021
13
Antifungal efficacy of isavuconazole and liposomal amphotericin B in a rabbit model of Exserohilum rostratum meningoencephalitis: A preclinical paradigm for management of CNS phaeohyphomycosis. 61
33313821 2021
14
Meningoencephalitis, Vasculitis, and Abortions Caused by Chlamydia pecorum in a Herd of Cattle. 61
33590807 2021
15
Quality of life of HIV-negative, previously healthy individuals following cryptococcal meningoencephalitis. 61
33574462 2021
16
Efficacy and Pharmacokinetics of Fosmanogepix (APX001) in the Treatment of Candida Endophthalmitis and Hematogenous Meningoencephalitis in Nonneutropenic Rabbits. 61
33361304 2021
17
Evaluation of cell-based and tissue-based immunofluorescent assays for detection of glial fibrillary acidic protein autoantibodies in the cerebrospinal fluid of dogs with meningoencephalitis of unknown origin and other central nervous system disorders. 61
33480282 2021
18
Benznidazole in Cerebrospinal Fluid: a Case Series of Chagas Disease Meningoencephalitis in HIV-Positive Patients. 61
33361290 2021
19
A systematic review of neurological symptoms and complications of COVID-19. 61
32691236 2021
20
Delayed onset hypophysitis after therapy with daclizumab for multiple sclerosis - A report of two cases. 61
33387829 2021
21
Meningoencephalitis caused by Cryptococcus neoformans and varicella zoster in a patient with systemic lupus erythematosus. 61
33541801 2021
22
Systemic coccidioidomycosis in a llama cria native to Missouri. 61
33583365 2021
23
In vitro synergistic effects of fluoxetine and paroxetine in combination with amphotericin B against Cryptococcus neoformans. 61
33417701 2021
24
Making Sense of the Biodiversity and Virulence of Listeria monocytogenes. 61
33583696 2021
25
The first two cases of neurotoxocariasis in Taiwan. 61
33593692 2021
26
Mitochondrial dynamics in Angiostrongylus cantonensis-infected mouse brain. 61
33147498 2021
27
Clinical and laboratory profile of patients with Kyasanur forest disease: A single-centre study of 192 patients from Karnataka, India. 61
33493988 2021
28
Next-generation Sequencing of Cerebrospinal Fluid for the Diagnosis of Unexplained Central Nervous System Infections. 61
33310532 2021
29
Bortezomib for treatment of anti-NMDA receptor encephalitis in a pediatric patient refractory to conventional therapy. 61
33547464 2021
30
Magnetic resonance imaging in dogs with neuroangiostrongyliasis (rat lungworm disease). 61
32951620 2021
31
Exploring the Anti-Infective Value of Inuloxin A Isolated from Inula viscosa against the Brain-Eating Amoeba (Naegleria fowleri) by Activation of Programmed Cell Death. 61
33296597 2021
32
ADAM15 Participates in Tick-Borne Encephalitis Virus Replication. 61
33208450 2021
33
Drug discovery for primary amebic meningoencephalitis: from screen to identification of leads. 61
33496193 2021
34
Geographic Range of Recreational Water-Associated Primary Amebic Meningoencephalitis, United States, 1978-2018. 61
33350926 2021
35
Differential neurovirulence of Usutu virus lineages in mice and neuronal cells. 61
33407600 2021
36
Correlation between CSF biomarkers and COVID-19 meningoencephalitis: A case series. 61
33398243 2021
37
Neuropathology of COVID-19 (neuro-COVID): clinicopathological update. 61
33554218 2021
38
Spectrum of neuroimaging findings in COVID-19. 61
33305996 2021
39
Cerebrospinal fluid findings in neurological diseases associated with COVID-19 and insights into mechanisms of disease development. 61
33127503 2021
40
Neurological symptoms, manifestations, and complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 19 (COVID-19). 61
33486564 2021
41
Overlapping central and peripheral nervous system syndromes in MOG antibody-associated disorders. 61
33272955 2021
42
The epidemiology and clinical spectrum of infections of the central nervous system in adults in north India. 61
33019910 2021
43
Late complication of cochlear implantation: Necrotizing meningoencephalitis. 61
33454085 2021
44
Meningoencephalitis with chondrocranial subcutaneous abscessation and septicaemia in a captive lemon shark (Negaprion brevirostris). 61
33048375 2021
45
Pseudomonal Meningoencephalitis With Ventriculitis Secondary to Bacteremia in a Burn Patient: A Novel Case. 61
33484564 2021
46
Cryptococcus bacillisporus (VGIII) Meningoencephalitis Acquired in Santa Cruz, Bolivia. 61
33467409 2021
47
Diagnostic evaluation of fatal Balamuthia mandrillaris meningoencephalitis in a captive Bornean orangutan (Pongo pygmaeus) with identification of potential environmental source and evidence of chronic exposure. 61
32920664 2021
48
MMR Vaccine Susceptibility of Viral Agents Causing Meningitis and Meningoencephalitis in Children. 61
33461475 2021
49
Uncommon manifestations of a rare disease: a case of autoimmune GFAP astrocytopathy. 61
33504323 2021
50
Diagnosis of Hyper IgM syndrome in a Previously Healthy Adolescent Boy Presented with Cutaneous and Cerebral Cryptococcosis. 61
33060515 2021

Variations for Meningoencephalitis

Expression for Meningoencephalitis

Search GEO for disease gene expression data for Meningoencephalitis.

Pathways for Meningoencephalitis

Pathways related to Meningoencephalitis according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 SERPINA3 IL6 GDNF CXCL2 CD79A CD40LG
2
Show member pathways
13.52 NGF IL6 GDNF CXCL2 CD40LG CD4
3
Show member pathways
13.25 IL6 GDNF CXCL2 CD40LG CD4 CCL5
4
Show member pathways
13.21 NGF IL6 CXCL2 CD40LG CD4 CCR6
5
Show member pathways
12.93 NGF IL6 CXCL2 CD40LG CD4 CCR6
6
Show member pathways
12.74 IL6 GDNF CD40LG CD4 B2M
7 12.35 CD79A CD40LG CCL5 CARD9 B2M
8
Show member pathways
12.22 IL6 CXCL2 CCR6 CCL5
9
Show member pathways
12.21 SERPINA3 IL6 CCL5 ALB
10 12.07 IL6 CXCL2 CCL5 CARD9
11 11.99 TAC1 NGF IL6 BDNF
12 11.67 NGF GDNF BDNF
13
Show member pathways
11.56 NGF BDNF APP
14 11.55 IL6 CD40LG CCR6
15
Show member pathways
11.52 IL6 CXCL2 CD40LG
16 11.51 IL6 CXCL2 CCL5
17 11.36 IL6 CXCL2 CCL5
18
Show member pathways
11.17 NGF CD40LG BDNF APP
19 11.16 CD79A CD40LG CD4
20 11.1 MBP IL6 GDNF CXCL2 BDNF
21 10.96 IL6 CXCL2 CD4
22 10.75 NGF IL6 CXCL2 CD40LG CCL5 BDNF

GO Terms for Meningoencephalitis

Cellular components related to Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TAC1 SERPINA3 NGF IL6 GDNF CXCL2
2 external side of plasma membrane GO:0009897 9.72 CD79A CD40LG CD4 CCR6 B2M
3 cell surface GO:0009986 9.7 MBP CD40LG CD4 CCR6 C5AR1 B2M
4 endoplasmic reticulum lumen GO:0005788 9.65 IL6 CD4 B2M APP ALB
5 platelet alpha granule lumen GO:0031093 9.54 SERPINA3 APP ALB
6 extracellular space GO:0005615 9.4 TAC1 SERPINA3 NGF IL6 GDNF CXCL2

Biological processes related to Meningoencephalitis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.1 TACR3 IL6 GDNF CXCL2 CD40LG CD4
2 G protein-coupled receptor signaling pathway GO:0007186 10.09 TACR3 TAC1 CXCL2 CCR6 CCL5 C5AR1
3 cellular protein metabolic process GO:0044267 9.89 IL6 B2M APP ALB
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.86 CD4 CCL5 C5AR1 APP
5 chemotaxis GO:0006935 9.8 CXCL2 CCR6 CCL5 C5AR1
6 negative regulation of neuron apoptotic process GO:0043524 9.78 NGF GDNF C5AR1 BDNF
7 neutrophil chemotaxis GO:0030593 9.77 CXCL2 CCL5 C5AR1
8 chemokine-mediated signaling pathway GO:0070098 9.76 CXCL2 CCR6 CCL5
9 positive regulation of protein binding GO:0032092 9.74 CLDN5 B2M APP
10 positive regulation of interleukin-6 production GO:0032755 9.67 MBP IL6 CARD9 APP
11 maintenance of permeability of blood-brain barrier GO:0035633 9.63 MBP IL6 CLDN5
12 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.62 NGF IL6 BDNF APP
13 response to molecule of bacterial origin GO:0002237 9.61 CXCL2 B2M
14 peripheral nervous system development GO:0007422 9.61 NGF GDNF BDNF
15 modulation of age-related behavioral decline GO:0090647 9.58 B2M APP
16 positive regulation of T cell proliferation GO:0042102 9.56 IL6 CD40LG CD4 CCL5
17 positive regulation of collateral sprouting GO:0048672 9.54 NGF BDNF
18 tachykinin receptor signaling pathway GO:0007217 9.52 TACR3 TAC1
19 positive regulation of receptor binding GO:1900122 9.51 BDNF B2M
20 inflammatory response GO:0006954 9.5 TAC1 SERPINA3 IL6 CXCL2 CD40LG CCL5
21 response to peptidoglycan GO:0032494 9.33 IL6 CARD9 C5AR1
22 immune response GO:0006955 9.28 MBP IL6 CXCL2 CD40LG CD4 CCR6

Molecular functions related to Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.86 CLDN5 CD79A CD4 CCL5 CARD9 B2M
2 cytokine activity GO:0005125 9.62 IL6 CXCL2 CD40LG CCL5
3 signaling receptor binding GO:0005102 9.55 NGF GDNF CD4 BDNF APP
4 nerve growth factor receptor binding GO:0005163 8.96 NGF BDNF
5 growth factor activity GO:0008083 8.92 NGF IL6 GDNF BDNF

Sources for Meningoencephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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