MCID: MNN009
MIFTS: 49

Meningoencephalitis

Categories: Neuronal diseases

Aliases & Classifications for Meningoencephalitis

MalaCards integrated aliases for Meningoencephalitis:

Name: Meningoencephalitis 12 54 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10554
MeSH 43 D008590
NCIt 49 C34813
SNOMED-CT 67 7125002
ICD10 32 A69.22
UMLS 71 C0025309

Summaries for Meningoencephalitis

Disease Ontology : 12 A central nervous system disease that involves encephalitis which occurs along with meningitis.

MalaCards based summary : Meningoencephalitis is related to listeriosis and meningitis. An important gene associated with Meningoencephalitis is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Immunologic Factors and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and testes, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 74 Meningoencephalitis (/mɪˌnɪŋɡoʊɛnˌsɛfəˈlaɪtɪs, -ˌnɪndʒoʊ-, -ən-, -ˌkɛ-/; from Greek μῆνιγξ meninx,... more...

Related Diseases for Meningoencephalitis

Diseases related to Meningoencephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 980)
# Related Disease Score Top Affiliating Genes
1 listeriosis 31.9 IL6 CD4 CCR6
2 meningitis 31.6 IL6 GDNF CD40LG CCL5 ALB
3 vasculitis 31.5 SERPINA3 IL6 CD79A CD40LG
4 chlamydia 31.2 IL6 CD79A CD40LG
5 cryptococcosis 31.2 CD4 CCR6 CARD9
6 parotitis 31.2 CD79A CD40LG CD4 ALB
7 chickenpox 31.1 IL6 CD40LG CD4 CCR6 ALB
8 herpes zoster 31.1 CD40LG CD4 CCR6
9 viral meningitis 31.0 IL6 CD40LG CCL5 B2M
10 exanthem 31.0 IL6 CD40LG CD4 CCR6 ALB
11 purpura 31.0 IL6 CD79A CD40LG
12 optic neuritis 31.0 MBP IL6 GDNF BDNF
13 hydrocephalus 30.9 SERPINA3 NGF MBP GDNF BDNF APP
14 chronic meningitis 30.9 CD40LG CD4 ALB
15 q fever 30.9 IL6 CD40LG CCL5
16 epidemic typhus 30.9 CD40LG CD4 CCL5
17 chlamydia pneumonia 30.9 IL6 CD40LG CD4
18 myelitis 30.8 MBP IL6 CD40LG CCR6
19 otitis media 30.8 IL6 CD79A CD40LG CCL5 ALB
20 neuritis 30.8 MBP IL6 GDNF CCL5 BDNF
21 acute disseminated encephalomyelitis 30.8 MBP CD40LG CCR6
22 facial paralysis 30.8 CD40LG CD4 ALB
23 pleural empyema 30.8 CD79A CD40LG CD4 ALB
24 cranial nerve palsy 30.8 CD40LG CD4 ALB
25 papilledema 30.7 SERPINA3 CD40LG CD4
26 rabies 30.7 CD40LG CCL5 ALB
27 orchitis 30.7 IL6 CD40LG CD4
28 cytomegalovirus infection 30.7 IL6 CCL5 B2M
29 cysticercosis 30.7 IL6 CD40LG CD4
30 endophthalmitis 30.7 IL6 CD4 CARD9 ALB
31 pneumonia 30.7 IL6 CXCL2 CD40LG CCL5 C5AR1 ALB
32 chorioretinitis 30.7 IL6 CD40LG CD4
33 coccidioidomycosis 30.7 CD40LG CD4 CCR6 CARD9
34 typhoid fever 30.6 IL6 CD40LG CCR6 ALB
35 chronic graft versus host disease 30.6 CD79A CD4 ALB
36 peritonitis 30.6 IL6 CXCL2 CCL5 B2M ALB
37 iridocyclitis 30.6 IL6 CD40LG CD4
38 cerebritis 30.6 CXCL2 CD40LG CD4 C5AR1
39 guillain-barre syndrome 30.5 MBP CD79A CD40LG CCR6 ALB
40 human immunodeficiency virus type 1 30.5 GDNF CD4 CCL5 C5AR1 B2M
41 neuromyelitis optica 30.5 MBP IL6 CD40LG
42 asymptomatic neurosyphilis 30.5 CD40LG CD4
43 viral encephalitis 30.5 MBP IL6 CD40LG CD4 CCR6 CCL5
44 candidiasis 30.5 IL6 CD40LG CCR6 CARD9
45 traumatic brain injury 30.5 MBP IL6 BDNF
46 miliary tuberculosis 30.5 CD40LG CD4 ALB
47 kawasaki disease 30.4 IL6 CD40LG CD4 ALB
48 encephalomalacia 30.4 MBP IL6 BDNF
49 rhinitis 30.4 NGF IL6 CCL5 ALB
50 mucormycosis 30.4 CD4 CCR6 CARD9

Graphical network of the top 20 diseases related to Meningoencephalitis:



Diseases related to Meningoencephalitis

Symptoms & Phenotypes for Meningoencephalitis

MGI Mouse Phenotypes related to Meningoencephalitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.2 ALB APP B2M BDNF C5AR1 CARD9
2 hematopoietic system MP:0005397 10.15 APP B2M C5AR1 CARD9 CCL5 CCR6
3 cardiovascular system MP:0005385 10.14 ALB APP B2M CCR6 CD40LG CLDN5
4 immune system MP:0005387 10.07 ALB APP B2M C5AR1 CARD9 CCL5
5 integument MP:0010771 9.81 APP B2M BDNF CD4 CD40LG IL6
6 nervous system MP:0003631 9.77 APP B2M BDNF C5AR1 CCR6 CD4
7 normal MP:0002873 9.28 ALB APP BDNF CCR6 CD4 CD79A

Drugs & Therapeutics for Meningoencephalitis

Drugs for Meningoencephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 3
2 Immunoglobulins Phase 3
3 Antibodies Phase 3
4 Rho(D) Immune Globulin Phase 3
5 Immunoglobulins, Intravenous Phase 3
6 gamma-Globulins Phase 3
7
Fluconazole Approved, Investigational Phase 2 86386-73-4 3365
8
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
9
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
10
Aluminum sulfate Approved Phase 2 10043-01-3
11
Aluminum hydroxide Approved, Investigational Phase 2 21645-51-2
12
Amphotericin B Approved, Investigational Phase 2 1397-89-3 5280965 14956
13
Tamoxifen Approved Phase 2 10540-29-1 2733526
14
Valganciclovir Approved, Investigational Phase 2 175865-60-8 64147
15 Pleconaril Investigational Phase 2 153168-05-9
16 Anti-Infective Agents Phase 2
17 Antiparasitic Agents Phase 2
18 Antiviral Agents Phase 2
19 Anti-Bacterial Agents Phase 2
20 Antiprotozoal Agents Phase 2
21 Cytochrome P-450 Enzyme Inhibitors Phase 2
22 Hormone Antagonists Phase 2
23 Hormones Phase 2
24 Antifungal Agents Phase 2
25 Vaccines Phase 2
26 Antacids Phase 2
27 Adjuvants, Immunologic Phase 2
28 Anti-Ulcer Agents Phase 2
29 Gastrointestinal Agents Phase 2
30 Antineoplastic Agents, Hormonal Phase 2
31 Amebicides Phase 2
32 Estrogen Antagonists Phase 2
33 Estrogen Receptor Antagonists Phase 2
34 Estrogen Receptor Modulators Phase 2
35 Liposomal amphotericin B Phase 2
36 Estrogens Phase 2
37
Acyclovir Approved 59277-89-3 2022
38
Ceftriaxone Approved 73384-59-5 5361919 5479530
39
Nevirapine Approved 129618-40-2 4463
40
Stavudine Approved, Investigational 3056-17-5 18283
41
Lamivudine Approved, Investigational 134678-17-4 60825
42
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
43 Antiemetics
44
dipyrone 522325
45 Antipyretics
46 Antibiotics, Antitubercular
47 Antimalarials
48 Reverse Transcriptase Inhibitors
49 Anti-HIV Agents
50 Anti-Retroviral Agents

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 A Phase III Multi-centre Randomised, Double Blind, Placebo Controlled Trial to Assess the Role of Intravenous Immunoglobulin in the Management of Children With Encephalitis Active, not recruiting NCT02308982 Phase 3 Immunoglobulins, Intravenous (Privigen);Placebo
2 A Phase II Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants Completed NCT01399853 Phase 2
3 A Booster Dose of Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children Completed NCT01734408 Phase 2
4 A Randomized Trial of Tamoxifen Combined With Amphotericin B and Fluconazole for Cryptococcal Meningitis Completed NCT03112031 Phase 2 Tamoxifen;Amphotericin B;Fluconazole
5 Double Blinded Placebo Controlled Study to Assess Clinical and Antiviral Activity of Valganciclovir (VAL) in Solid Organ Transplant Donors to Reduce Viral Transmission From Donor to Recipient Completed NCT01329185 Phase 2 Valganciclovir;Placebo
6 A Double-Blind, Placebo-Controlled, Virologic Efficacy Trial of Pleconaril in the Treatment of Neonates With Enteroviral Sepsis Syndrome Completed NCT00031512 Phase 2 Placebo;Pleconaril (VP63843)
7 A Randomized Double Blind Placebo Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin (IVIG) in Children With Japanese Encephalitis in Nepal Completed NCT01856205 Phase 2 Intravenous immunoglobulin [ImmunoRel™ (batch 20081217)]
8 Pharmacokinetic Study of AVI-4020 in Cerebral Spinal Fluid Among Healthy Adult Males Following Intravenous Administration Completed NCT00387283 Phase 1 AVI-4020 Injection
9 A Phase Ib Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants Completed NCT01313715 Phase 1
10 A Phase Ia Clinical Trial for Inactivated Vaccine(Vero Cell) Against EV71 in Chinese Healthy Young Adults and Children Completed NCT01267903 Phase 1
11 An Exploratory Study of the Safety, Tolerability, Pharmacokinetics and Potential Effectiveness of AVI-4020 Injection in Patients Presenting With Presumptive Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
12 Prospective Study of the Etiology, Pathogenesis, Clinical Picture and Outcome of Aseptic Meningitis in Slovenia Unknown status NCT02328469 symptomatic therapy;Ceftriaxone or Doxycycline;Acyclovir
13 Etiology of Orphan Community-based Meningitis and Meningo-encephalitis. Unknown status NCT02868593
14 Implementation and Evaluation of a Screening Strategy to Reduce Morbidity and Mortality Due to Cryptoccocal Meningo-encephalitis in ART Naive AIDS Patients With <100 CD4 Count at the Day Hospital of the Yaounde Central Hospital, Cameroon Unknown status NCT02624453 Fluconazole;Antiretroviral therapy
15 sCD163 as a Potential Biomarker in Guillain- Barré Syndrome Unknown status NCT02582853
16 sCD163 & CD19 as Candidate Biomarkers in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) - A Study of sCD163 in the Cerebrospinal Fluid Unknown status NCT02271724
17 Cognitive Impairment and Neuropsychiatric Manifestations of Neurobrucellosis Completed NCT04301752
18 Cerebrospinal Fluid Polymerase Chain Reaction Arrays for Central Nervous System Neurotropic Viral Infection and Mycobacterium Infection Study Completed NCT00807378
19 Randomized Control Trial of Early vs Delayed ART in the Treatment of Cryptococcal Meningitis. Completed NCT00830856 Fluconazole;Fixed dose - Stavudine, lamivudine and Nevirapine;Fixed dose - Stavudine, Lamivudine, Nevirapine
20 Inflammation in Amyotrophic Lateral Sclerosis - a Study of Soluble Cluster of Differentiation 163 in the Cerebrospinal Fluid Completed NCT02325375
21 Application of Next Generation Sequencing Technique in Pediatric Bacterial Meningitis Recruiting NCT03953638
22 Research for Angiostrongylus Cantonensis and Costaricensis in French West Indies and French Guiana: a Clinical and Environmental Study Recruiting NCT03378882
23 Fever After Tick Bite (FATB) Study; Determining the Etiology of Tick-Borne Human Infections in Northern Europe Recruiting NCT03932448
24 The Identification and Quantification of HIV CNS Latency Biomarkers Recruiting NCT02989285
25 Integrating the Diagnosis and Management of HIV-associated Central Nervous System (CNS) Infections Into Routine Health Services in Low and Middle Income Countries (LMICs) Recruiting NCT03226379
26 Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients Active, not recruiting NCT02207647
27 Prospective Investigation of Oxidative Stress in West Nile Virus Infection Not yet recruiting NCT04371003

Search NIH Clinical Center for Meningoencephalitis

Cochrane evidence based reviews: meningoencephalitis

Genetic Tests for Meningoencephalitis

Anatomical Context for Meningoencephalitis

MalaCards organs/tissues related to Meningoencephalitis:

40
Brain, T Cells, Testes, Endothelial, Kidney, Neutrophil, Liver

Publications for Meningoencephalitis

Articles related to Meningoencephalitis:

(show top 50) (show all 7057)
# Title Authors PMID Year
1
HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele. 61 54
19675171 2009
2
Abeta-induced meningoencephalitis is IFN-gamma-dependent and is associated with T cell-dependent clearance of Abeta in a mouse model of Alzheimer's disease. 54 61
16549802 2006
3
Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease. 54 61
14997933 2004
4
Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice. 54 61
12805119 2003
5
No evidence for elevated numbers of mononuclear cells expressing MCP-1 and RANTES mRNA in blood and CSF in multiple sclerosis. 61 54
9846826 1998
6
A substance P antagonist, RP-67,580, ameliorates a mouse meningoencephalitic response to Trypanosoma brucei brucei. 54 61
9108123 1997
7
Antimyelin basic protein and antimyelin antibody-producing cells in multiple sclerosis. 61 54
1690527 1990
8
Neonatal acute liver failure due to enteroviruses: a 14 years single NICU experience. 61
30513031 2020
9
Angiostrongylus cantonensis activates inflammasomes in meningoencephalitic BALB/c mice. 61
32283319 2020
10
Naegleria fowleri: differential genetic expression following treatment with Hesperidin conjugated with silver nanoparticles using RNA-Seq. 61
32451717 2020
11
COVID-19-associated meningoencephalitis complicated with intracranial hemorrhage: a case report. 61
32430637 2020
12
Meningoencephalitis without respiratory failure in a young female patient with COVID-19 infection in Downtown Los Angeles, early April 2020. 61
32305574 2020
13
Plasmapheresis treatment in COVID-19-related autoimmune meningoencephalitis: Case series. 61
32389697 2020
14
Fever, nausea and vomiting, and CSF pleocytosis must be meningoencephalitis, right? No, think again! 61
32244039 2020
15
Glial fibrillary acidic protein (GFAP) associated autoimmune meningoencephalitis in a patient receiving nivolumab. 61
32416558 2020
16
Central nervous system complications associated with immune checkpoint inhibitors. 61
32312871 2020
17
Identification of differential protein recognition pattern between Naegleria fowleri and Naegleria lovaniensis. 61
32191816 2020
18
Adaptive iron utilization compensates for the lack of an inducible uptake system in Naegleria fowleri and represents a potential target for therapeutic intervention. 61
32555641 2020
19
Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating Amoebae. 61
32548431 2020
20
The MPO system participates actively in the formation of an oxidative environment produced by neutrophils and activates the antioxidant mechanism of Naegleria fowleri. 61
32531828 2020
21
Important factors causing high fatal cases of Naegleria fowleri primary amoebic meningoencephalitis in Pakistan. 61
32497800 2020
22
The excretory/secretory products of fifth-stage larval Angiostrongylus cantonensis induces autophagy via the Sonic hedgehog pathway in mouse brain astrocytes. 61
32479527 2020
23
Molecular cloning and characterization of a cathepsin L-like cysteine protease of Angiostrongylus cantonensis. 61
31756482 2020
24
Polyneuritis cranialis and vasculopathy caused by varicella zoster virus without rash. 61
32524536 2020
25
Meningoencephalitis due to Spotted Fever Rickettsioses, Including Rocky Mountain Spotted Fever. 61
31412360 2020
26
Comparison of tick-borne encephalitis between children and adults-analysis of 669 patients. 61
32524423 2020
27
Acute meningoencephalitis in a patient with COVID-19. 61
32414534 2020
28
Neurological involvement of coronavirus disease 2019: a systematic review. 61
32561990 2020
29
Zika virus in Brazil and worldwide: a narrative review. 61
32576082 2020
30
Listeria monocytogenes septicemia and meningoencephalitis associated with relapsed and refractory follicular lymphoma. 61
32033853 2020
31
Next-generation sequencing of cerebrospinal fluid for the diagnosis of neurocysticercosis. 61
32220712 2020
32
Excretory/secretory products of Angiostrongylus cantonensis fifth-stage larvae induce endoplasmic reticulum stress via the Sonic hedgehog pathway in mouse astrocytes. 61
32552877 2020
33
Human Parvoviruses May Affect the Development and Clinical Course of Meningitis and Meningoencephalitis. 61
32503112 2020
34
Herpes Simplex Virus 2 Meningoencephalitis-Associated Bilateral Optic Neuritis and Radiculitis. 61
32395172 2020
35
Postpartum meningoencephalitis and spinal tuberculosis. 61
29102528 2020
36
Inhibition of fatty acid oxidation as a new target to treat Primary Amoebic Meningoencephalitis. 61
32513800 2020
37
An undescribed species of Sarcocystis associated with necrotizing meningoencephalitis in naturally infected backyard chickens in the Midwest of Brazil. 61
32120051 2020
38
A Case with Purine Nucleoside Phosphorylase Deficiency Suffering from Late-Onset Systemic Lupus Erythematosus and Lymphoma. 61
32514656 2020
39
Sarcoidosis with cryptococcal infection apparently engaging only immune-privileged body compartments: a case report. 61
32571242 2020
40
Toxocariasis of the Nervous System. 61
31960218 2020
41
Avian coxiellosis in nine psittacine birds, one black-browed barbet, and one paradise tanager. 61
32054295 2020
42
Evaluation of the anti-apoptotic activity of bovine alphaherpesvirus type 5 US3 protein kinase in insect cells using a recombinant baculovirus. 61
31907798 2020
43
The Added Value of Longitudinal Imaging for Preclinical In Vivo Efficacy Testing of Therapeutic Compounds against Cerebral Cryptococcosis. 61
32284382 2020
44
Identification of Immunogenic Antigens of Naegleria fowleri Adjuvanted by Cholera Toxin. 61
32531943 2020
45
POSTMORTEM COMPUTED TOMOGRAPHY AND MAGNETIC RESONANCE IMAGING FINDINGS IN A CASE OF COINFECTION OF DOLPHIN MORBILLIVIRUS AND ASPERGILLUS FUMIGATUS IN A JUVENILE BOTTLENOSE DOLPHIN (TURSIOPS TRUNCATUS). 61
32549578 2020
46
Apolipoprotein D. 61
32554047 2020
47
Development of a small animal model for deer tick virus pathogenesis mimicking human clinical outcome. 61
32542017 2020
48
Causes and Clinical Features of Childhood Encephalitis: A Multicenter, Prospective Cohort Study. 61
31549170 2020
49
Cerebrospinal fluid biomarkers in patients with central nervous system infections: a retrospective study. 61
31130152 2020
50
Production of IL-17A at Innate Immune Phase Leads to Decreased Th1 Immune Response and Attenuated Host Defense against Infection with Cryptococcus deneoformans. 61
32561568 2020

Variations for Meningoencephalitis

Expression for Meningoencephalitis

Search GEO for disease gene expression data for Meningoencephalitis.

Pathways for Meningoencephalitis

Pathways related to Meningoencephalitis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 SERPINA3 IL6 GDNF CXCL2 CD79A CD40LG
2
Show member pathways
13.52 NGF IL6 GDNF CXCL2 CD40LG CD4
3
Show member pathways
13.24 IL6 GDNF CXCL2 CD40LG CD4 CCL5
4
Show member pathways
13.21 NGF IL6 CXCL2 CD40LG CD4 CCR6
5
Show member pathways
12.93 NGF IL6 CXCL2 CD40LG CD4 CCR6
6
Show member pathways
12.74 IL6 GDNF CD40LG CD4 B2M
7 12.35 CD79A CD40LG CCL5 CARD9 B2M
8
Show member pathways
12.21 IL6 CXCL2 CCR6 CCL5
9
Show member pathways
12.2 SERPINA3 IL6 CCL5 ALB
10 12.07 IL6 CXCL2 CCL5 CARD9
11 11.99 TAC1 NGF IL6 BDNF
12 11.67 NGF GDNF BDNF
13
Show member pathways
11.55 NGF BDNF APP
14
Show member pathways
11.52 IL6 CXCL2 CD40LG
15 11.51 IL6 CXCL2 CCL5
16 11.36 IL6 CXCL2 CCL5
17
Show member pathways
11.17 NGF CD40LG BDNF APP
18 11.16 CD79A CD40LG CD4
19 11.1 MBP IL6 GDNF CXCL2 BDNF
20 10.96 IL6 CXCL2 CD4
21 10.75 NGF IL6 CXCL2 CD40LG CCL5 BDNF

GO Terms for Meningoencephalitis

Cellular components related to Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.91 TAC1 IL6 CD4 CCR6 CCL5 C5AR1
2 extracellular region GO:0005576 9.73 TAC1 SERPINA3 NGF IL6 GDNF CXCL2
3 external side of plasma membrane GO:0009897 9.72 CD79A CD40LG CD4 CCR6 B2M
4 cell surface GO:0009986 9.7 MBP CD40LG CD4 CCR6 C5AR1 B2M
5 endoplasmic reticulum lumen GO:0005788 9.65 IL6 CD4 B2M APP ALB
6 platelet alpha granule lumen GO:0031093 9.58 SERPINA3 APP ALB
7 extracellular space GO:0005615 9.4 TAC1 SERPINA3 NGF IL6 GDNF CXCL2

Biological processes related to Meningoencephalitis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 10.07 TACR3 TAC1 CXCL2 CCR6 CCL5 C5AR1
2 signal transduction GO:0007165 10.07 TACR3 IL6 GDNF CXCL2 CD40LG CD4
3 negative regulation of apoptotic process GO:0043066 9.93 NGF IL6 GDNF CD40LG BDNF ALB
4 cellular protein metabolic process GO:0044267 9.9 IL6 B2M APP ALB
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.87 CD4 CCL5 C5AR1 APP
6 chemotaxis GO:0006935 9.8 CXCL2 CCR6 CCL5 C5AR1
7 neutrophil chemotaxis GO:0030593 9.78 CXCL2 CCL5 C5AR1
8 negative regulation of neuron apoptotic process GO:0043524 9.78 NGF GDNF C5AR1 BDNF
9 chemokine-mediated signaling pathway GO:0070098 9.77 CXCL2 CCR6 CCL5
10 positive regulation of protein binding GO:0032092 9.76 CLDN5 B2M APP
11 learning or memory GO:0007611 9.73 BDNF B2M APP
12 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.62 NGF IL6 BDNF APP
13 response to molecule of bacterial origin GO:0002237 9.61 CXCL2 B2M
14 maintenance of permeability of blood-brain barrier GO:0035633 9.61 MBP IL6 CLDN5
15 modulation of age-related behavioral decline GO:0090647 9.58 B2M APP
16 peripheral nervous system development GO:0007422 9.58 NGF GDNF BDNF
17 positive regulation of T cell proliferation GO:0042102 9.56 IL6 CD40LG CD4 CCL5
18 positive regulation of collateral sprouting GO:0048672 9.55 NGF BDNF
19 tachykinin receptor signaling pathway GO:0007217 9.54 TACR3 TAC1
20 positive regulation of receptor binding GO:1900122 9.51 BDNF B2M
21 inflammatory response GO:0006954 9.5 TAC1 SERPINA3 IL6 CXCL2 CD40LG CCL5
22 response to peptidoglycan GO:0032494 9.33 IL6 CARD9 C5AR1
23 immune response GO:0006955 9.28 MBP IL6 CXCL2 CD40LG CD4 CCR6

Molecular functions related to Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.21 TACR3 SERPINA3 NGF MBP IL6 GDNF
2 cytokine activity GO:0005125 9.62 IL6 CXCL2 CD40LG CCL5
3 signaling receptor binding GO:0005102 9.55 NGF GDNF CD4 BDNF APP
4 nerve growth factor receptor binding GO:0005163 8.96 NGF BDNF
5 growth factor activity GO:0008083 8.92 NGF IL6 GDNF BDNF

Sources for Meningoencephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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