MCID: MNN022
MIFTS: 21

Meningoencephalocele

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Meningoencephalocele

MalaCards integrated aliases for Meningoencephalocele:

Name: Meningoencephalocele 20
Meningo-Encephalocele 70
Encephalomeningocele 20

Classifications:



External Ids:

UMLS 70 C3825985

Summaries for Meningoencephalocele

GARD : 20 Meningoencephalocele is a type of encephalocele, which is an abnormal sac of fluid, brain tissue, and meninges (membranes that cover the brain and spinal cord) that extends through a defect in the skull. There are two main types of meningoencephalocele, which are named according to the location of the sac. The frontoethmoidal type is located at the frontal and ethmoid bones while the occipital type is located at the occipital bone. Hydrocephalus, abnormalities of the eyeball and tear duct, and other findings have been associated with the condition. Some affected individuals have intellectual or physical disabilities while others have normal development and abilities. The condition is typically congenital (present at birth) but has been reported to develop by chance in older individuals in rare cases. The underlying cause of the condition is uncertain, but environmental factors are thought to play a role. Treatment depends on the size, location and severity of the defect but mainly includes magnetic resonance imaging (MRI) to determine the severity of the defect, followed by surgery to repair it.

MalaCards based summary : Meningoencephalocele, also known as meningo-encephalocele, is related to podder-tolmie syndrome and meckel syndrome, type 2. An important gene associated with Meningoencephalocele is RMND5A (Required For Meiotic Nuclear Division 5 Homolog A). Affiliated tissues include spinal cord, pituitary and heart.

Wikipedia : 73 Encephalocele is a neural tube defect characterized by sac-like protrusions of the brain and the... more...

Related Diseases for Meningoencephalocele

Diseases related to Meningoencephalocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 podder-tolmie syndrome 11.0
2 meckel syndrome, type 2 10.9
3 encephalocele 10.4
4 meningocele 10.4
5 meningitis 10.3
6 cerebrospinal fluid leak 10.3
7 mollaret meningitis 10.2
8 hydrocephalus 10.2
9 cleft palate, isolated 10.1
10 exophthalmos 10.1
11 intracranial hypertension 10.1
12 cleft lip 10.1
13 bacterial meningitis 10.1
14 craniosynostosis 10.0
15 neurofibromatosis 10.0
16 cleft lip/palate 10.0
17 hypertelorism 10.0
18 otitis media 10.0
19 neural tube defects 10.0
20 strabismus 10.0
21 mechanical strabismus 10.0
22 neurofibroma 10.0
23 frontal encephalocele 10.0
24 basal encephalocele 10.0
25 frontonasal dysplasia 1 9.9
26 telecanthus 9.9
27 meningioma, familial 9.9
28 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
29 corpus callosum, agenesis of, with facial anomalies and cerebellar ataxia 9.9
30 ptosis 9.9
31 myelomeningocele 9.9
32 superior semicircular canal dehiscence 9.9
33 benign teratoma 9.9
34 intracranial meningioma 9.9
35 meningoencephalitis 9.9
36 microcephaly 9.9
37 pulsating exophthalmos 9.9
38 ventricular septal defect 9.9
39 heart septal defect 9.9
40 cystic teratoma 9.9
41 temporal lobe epilepsy 9.9
42 rhinitis 9.9
43 secretory meningioma 9.9
44 lymphoplasmacyte-rich meningioma 9.9
45 holoprosencephaly 9.9
46 plexiform neurofibroma 9.9
47 pituitary gland disease 9.9
48 mature teratoma 9.9
49 eye disease 9.9
50 hypopituitarism 9.9

Graphical network of the top 20 diseases related to Meningoencephalocele:



Diseases related to Meningoencephalocele

Symptoms & Phenotypes for Meningoencephalocele

Drugs & Therapeutics for Meningoencephalocele

Search Clinical Trials , NIH Clinical Center for Meningoencephalocele

Genetic Tests for Meningoencephalocele

Anatomical Context for Meningoencephalocele

MalaCards organs/tissues related to Meningoencephalocele:

40
Spinal Cord, Pituitary, Heart, Eye, Temporal Lobe, Brain, Olfactory Bulb

Publications for Meningoencephalocele

Articles related to Meningoencephalocele:

(show top 50) (show all 500)
# Title Authors PMID Year
1
Spontaneous Tegmen Tympani Dehiscence: Causes and Treatment of Conductive Hearing Loss. 61
33741818 2021
2
Simplifying Access to the Lateral Sphenoid Recess: A Modification of the Transpterygoid Approach. 61
33761785 2021
3
Nasoseptal Flap for Skull Base Reconstruction in a Three-Year-Old Child With Nasofrontal Meningoencephalocele. 61
33645258 2021
4
Potential Efficacy of Multimodal Mixed Reality in Epilepsy Surgery. 61
33382064 2021
5
Transpalpebral transorbital neuroendoscopic (TONES) repair of orbital meningoencephalocele: a technical note. 61
33645364 2021
6
A case report of confusing meningoencephalocele. 61
33489143 2021
7
Nasal meningoencephalocele: A retrospective study of clinicopathological features and diagnosis of 16 patients. 61
32916632 2020
8
Outcomes of Middle Turbinate Flap in the Reconstruction of Non-tumorous Ventral Skull Base Defects - an Institutional Review. 61
33554195 2020
9
Endoscopic management of congenital nasal meningoencephaloceles: a short series of 15 paediatric cases. 61
32382868 2020
10
Endonasal endoscopic management of the craniopharyngeal canal meningoencephalocele using a nasoseptal flap in a 6-month-old infant. 61
32270272 2020
11
Further evidence for POMK as candidate gene for WWS with meningoencephalocele. 61
32907597 2020
12
Ethmoidal meningoencephalocele in a C57BL/6J mouse. 61
32787540 2020
13
Formation of a meningoencephalocele after removal of a frontal lobe meningioma by transfrontal craniotomy in a cat. 61
32983552 2020
14
Spontaneous symptomatic orbital meningoencephalocele in an adult patient. Case report and review of the literature. 61
32409212 2020
15
Spontaneous sphenoid meningoencephalocele with sepsis. 61
32675980 2020
16
Otogenic Pneumocephalus After Tegmen Bone Reconstruction: A Case Report. 61
32543228 2020
17
Spontaneous transethmoidal meningoencephalocele presenting in the form of recurrent unilateral nasal discharge: discussion of the diagnosis and endoscopic surgical management. 61
32404373 2020
18
[Cerebrospinal fluid otorrhea combined with meningoencephalocele of nasopharynx, cerebrospinal fluid leak: a case report]. 61
32842369 2020
19
Management of tegmen defects with mastoid and epitympanic obliteration using S53P4 bioactive glass. 61
32337361 2020
20
How long is the tail end of the learning curve? Results from 1000 consecutive endoscopic endonasal skull base cases following the initial 200 cases. 61
32032942 2020
21
Endoscopic Surgical Repair of a Giant, Postoperative, Neglected Meningoencephalocele. 61
32133261 2020
22
Whole exome sequencing identified a homozygous novel variant in CEP290 gene causes Meckel syndrome. 61
31840411 2020
23
Case Report: Surgical Treatment for Intranasal Meningoencephalocele in a Cat. 61
32974400 2020
24
Sphenoethmoidal meningoencephalocele with variable hypopituitarism: A case report and review of literature. 61
33088018 2020
25
[Sphenoid sinus meningoencephalocele in an adult patient]. 61
33425152 2020
26
Subventricular glial nodules in neurofibromatosis 1 with craniofacial dysmorphism and occipital meningoencephalocele. 61
31799455 2019
27
Endonasal endoscopic skullbase surgery in children. 61
31079184 2019
28
The reconstruction of skull base defects in infants using pedicled nasoseptal flap-a review of four cases. 61
30968177 2019
29
Streptococcus Oralis meningitis from right sphenoid Meningoencephalocele and cerebrospinal fluid leak. 61
31711423 2019
30
Surgical correction of a meningoencephalocele in a thoroughbred filly. 61
31135063 2019
31
Endoscopic endonasal resection of congenital trans-sphenoidal meningoencephalocele with extension to the epipharynx in early childhood: a case report. 61
32127849 2019
32
Incidental spontaneous CSF fistula with pterygoid process meningoencephalocele. 61
31380824 2019
33
Nasal Framework Osteotomy: An Innovative Approach to Manage an Extremely Long Nose With Meningoencephalocele. 61
30851254 2019
34
Clinical, radiological features and surgical strategies for 23 NF1 patients with intraorbital meningoencephalocele. 61
30868483 2019
35
Dermoid cyst with cerebellar meningoencephalocele at different locations accompanied by posterior fossa abnormalities: case report. 61
30156600 2019
36
Surgical Implications of the Anteriorly Displaced Segments of the Anterior Cerebral Artery in the Management of Frontoethmoidal Meningoencephalocele. 61
31048610 2019
37
Surgical management of meningoencephalocele in temporal bone associated with pharmacoresistant epilepsy: report of two cases. 61
29179608 2019
38
Delayed presentation of morning glory disc anomaly and transsphenoidal encephalocele: A management dilemma. 61
31312233 2019
39
Giant meningoencephalocele with Arnold-Chiari type III malformation and anaesthetic challenges: A rare case report. 61
31007660 2019
40
Iatrogenic meningoencephalocele after traumatic perforation of the cribriform plate during nasal intubation of a preterm infant. 61
30611097 2019
41
Temporal bone meningoencephaloceles and cerebrospinal fluid leaks: experience in a tertiary care hospital. 61
30777139 2019
42
Vascular malformation of the sphenoid and temporal bone: A diagnostic dilemma. 61
30482404 2019
43
Outcome of Endoscopic Cerebrospinal Fluid Rhinorrhoea Repair: An Institutional Study. 61
30906718 2019
44
Endoscopic Endonasal Repair of a Persistent Craniopharyngeal Canal and Sphenoid Meningoencephalocele: Case Report and Review of Literature. 61
30391602 2019
45
[The application of cartilage in middle ear surgery]. 61
30550140 2018
46
Endoscopic management of paediatric meningoencephaloceles: a case series. 61
30218386 2018
47
Normative Data of the Interorbital Distance in Thai Population. 61
30234716 2018
48
Masses of developmental and genetic origin affecting the paediatric craniofacial skeleton. 61
29766474 2018
49
Orbital and nasal meningoencephaloceles secondary to chronic hydrocephalus: A rare cause of bilateral proptosis. 61
29882488 2018
50
Ethmoid Meningoencephalocele in a Patient with Cerebrofacial Arteriovenous Metameric Syndrome. 61
29510289 2018

Variations for Meningoencephalocele

Expression for Meningoencephalocele

Search GEO for disease gene expression data for Meningoencephalocele.

Pathways for Meningoencephalocele

GO Terms for Meningoencephalocele

Sources for Meningoencephalocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
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39 LOVD
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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