MCID: MNN005
MIFTS: 25

Meningovascular Neurosyphilis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Meningovascular Neurosyphilis

MalaCards integrated aliases for Meningovascular Neurosyphilis:

Name: Meningovascular Neurosyphilis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050491

Summaries for Meningovascular Neurosyphilis

Disease Ontology : 12 A tertiary neurosyphilis that results in inflammation located in arteries of the brain or located in arteries of spinal cord. The infection has symptom headache, has symptom neck stiffness, has symptom dizziness, has symptom behavioral abnormalities, has symptom poor concentration, has symptom memory loss, has symptom lassitude, has symptom insomnia, has symptom blurred vision, has symptom weakness and wasting of shoulder-girdle and arm muscles, has symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has symptom paralysis of the legs due to thrombosis of spinal arteries.

MalaCards based summary : Meningovascular Neurosyphilis is related to syphilis and neurosyphilis, and has symptoms including headache, neck stiffness and dizziness. An important gene associated with Meningovascular Neurosyphilis is MBP (Myelin Basic Protein), and among its related pathways/superpathways is Primary immunodeficiency. Affiliated tissues include arteries of the brain or, brain and spinal cord.

Related Diseases for Meningovascular Neurosyphilis

Diseases related to Meningovascular Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 syphilis 29.9 CD40LG CD79A
2 neurosyphilis 11.6
3 post-vaccinal encephalitis 10.3 CD40LG MBP
4 transient arthritis 10.2 CD40LG MBP
5 spinal cord disease 10.2 CD40LG MBP
6 progressive multifocal leukoencephalopathy 10.1 CD40LG MBP
7 multiple cranial nerve palsy 10.1 CD40LG MBP
8 secondary progressive multiple sclerosis 10.1 CD40LG MBP
9 selective igg deficiency disease 10.0 CD40LG CD79A
10 c1q nephropathy 10.0 CD40LG CD79A
11 alpha chain disease 10.0 CD40LG CD79A
12 brill-zinsser disease 10.0 CD40LG CD79A
13 exudative glomerulonephritis 10.0 CD40LG CD79A
14 cork-handlers' disease 10.0 CD40LG CD79A
15 salpingo-oophoritis 10.0 CD40LG CD79A
16 early yaws 10.0 CD40LG CD79A
17 ventilation pneumonitis 10.0 CD40LG CD79A
18 chronic interstitial cystitis 10.0 CD40LG CD79A
19 axillary adenitis 10.0 CD40LG CD79A
20 cryofibrinogenemia 10.0 CD40LG CD79A
21 trichostrongyloidiasis 10.0 CD40LG CD79A
22 subacute bacterial endocarditis 10.0 CD40LG CD79A
23 heterophyiasis 10.0 CD40LG CD79A
24 immunoglobulin g deficiency 10.0 CD40LG CD79A
25 orbital granuloma 10.0 CD40LG CD79A
26 transient hypogammaglobulinemia of infancy 10.0 CD40LG CD79A
27 hyperglobulinemic purpura 10.0 CD40LG CD79A
28 gastroduodenitis 10.0 CD40LG CD79A
29 bacterial conjunctivitis 10.0 CD40LG CD79A
30 heavy chain disease 10.0 CD40LG CD79A
31 ophthalmia neonatorum 10.0 CD40LG CD79A
32 immunoglobulin a deficiency 1 10.0 CD40LG CD79A
33 parotid disease 10.0 CD40LG CD79A
34 cerebral arteritis 10.0 CD40LG CD79A
35 selective immunoglobulin deficiency disease 10.0 CD40LG CD79A
36 geniculate herpes zoster 10.0 CD40LG CD79A
37 erythema elevatum diutinum 10.0 CD40LG CD79A
38 thrombosis 10.0
39 hemiplegia 10.0
40 dementia 10.0
41 sporotrichosis 10.0 CD40LG CD79A
42 fallopian tube disease 10.0 CD40LG CD79A
43 hyperimmunoglobulin syndrome 10.0 CD40LG CD79A
44 congenital syphilis 10.0 CD40LG CD79A
45 polyclonal hypergammaglobulinemia 10.0 CD40LG CD79A
46 monoclonal paraproteinemia 10.0 CD40LG CD79A
47 salpingitis 10.0 CD40LG CD79A
48 ocular toxoplasmosis 10.0 CD40LG CD79A
49 congenital hypogammaglobulinemia 10.0 CD40LG CD79A
50 acute maxillary sinusitis 10.0 CD40LG CD79A

Graphical network of the top 20 diseases related to Meningovascular Neurosyphilis:



Diseases related to Meningovascular Neurosyphilis

Symptoms & Phenotypes for Meningovascular Neurosyphilis

Symptoms:

12 (show all 12)
  • headache
  • neck stiffness
  • dizziness
  • behavioral abnormalities
  • poor concentration
  • memory loss
  • lassitude
  • insomnia
  • blurred vision
  • weakness
  • slowly progressive leg weakness
  • paralysis of the legs due to thrombosis of spinal arteries

Drugs & Therapeutics for Meningovascular Neurosyphilis

Search Clinical Trials , NIH Clinical Center for Meningovascular Neurosyphilis

Genetic Tests for Meningovascular Neurosyphilis

Anatomical Context for Meningovascular Neurosyphilis

The Foundational Model of Anatomy Ontology organs/tissues related to Meningovascular Neurosyphilis:

19
Arteries Of The Brain Or

MalaCards organs/tissues related to Meningovascular Neurosyphilis:

41
Brain, Spinal Cord

Publications for Meningovascular Neurosyphilis

Articles related to Meningovascular Neurosyphilis:

# Title Authors Year
1
Meningovascular neurosyphilis with basilar artery thrombosis in HIV patient. ( 28993174 )
2017
2
Prevalence of positive syphilis serology and meningovascular neurosyphilis in patients admitted with stroke and TIA from a culturally diverse population (2005-09). ( 23669171 )
2013
3
Meningovascular neurosyphilis: a report of stroke in a young adult. ( 20571297 )
2010
4
Amnestic syndrome due to meningovascular neurosyphilis. ( 19997924 )
2010
5
Dementia following an acute presentation of meningovascular neurosyphilis in an HIV-1 positive patient. ( 10997420 )
2000
6
Meningovascular neurosyphilis in human immunodeficiency virus infection as a differential diagnosis of focal CNS lesions: a clinicopathological study. ( 8370947 )
1993
7
Pure motor hemiplegia due to meningovascular neurosyphilis. ( 3632380 )
1987
8
Poikiloderma atrophicans vasculare Jacobi; cutaneous changes typical of this disease in a patient with late meningovascular neurosyphilis. ( 21026343 )
1946

Variations for Meningovascular Neurosyphilis

Expression for Meningovascular Neurosyphilis

Search GEO for disease gene expression data for Meningovascular Neurosyphilis.

Pathways for Meningovascular Neurosyphilis

Pathways related to Meningovascular Neurosyphilis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.19 CD40LG CD79A

GO Terms for Meningovascular Neurosyphilis

Biological processes related to Meningovascular Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 8.96 CD40LG CD79A
2 B cell proliferation GO:0042100 8.62 CD40LG CD79A

Sources for Meningovascular Neurosyphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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