MCID: MNN005
MIFTS: 27

Meningovascular Neurosyphilis

Categories: Infectious diseases, Neuronal diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Meningovascular Neurosyphilis

MalaCards integrated aliases for Meningovascular Neurosyphilis:

Name: Meningovascular Neurosyphilis 11 14

Classifications:



External Ids:

Disease Ontology 11 DOID:0050491

Summaries for Meningovascular Neurosyphilis

Disease Ontology: 11 A tertiary neurosyphilis that results in inflammation located in arteries of the brain or located in arteries of spinal cord. The infection has symptom headache, has symptom neck stiffness, has symptom dizziness, has symptom behavioral abnormalities, has symptom poor concentration, has symptom memory loss, has symptom lassitude, has symptom insomnia, has symptom blurred vision, has symptom weakness and wasting of shoulder-girdle and arm muscles, has symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has symptom paralysis of the legs due to thrombosis of spinal arteries.

MalaCards based summary: Meningovascular Neurosyphilis is related to neurosyphilis and acquired immunodeficiency syndrome, and has symptoms including headache, neck stiffness and dizziness. An important gene associated with Meningovascular Neurosyphilis is CXCL13 (C-X-C Motif Chemokine Ligand 13), and among its related pathways/superpathways is Th17 Differentiation. Affiliated tissues include arteries of the brain, arteries of spinal cord and spinal cord.

Related Diseases for Meningovascular Neurosyphilis

Diseases related to Meningovascular Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 365)
# Related Disease Score Top Affiliating Genes
1 neurosyphilis 32.5 IL17A CXCL13
2 acquired immunodeficiency syndrome 30.0 MBP CRP CD4 ALB
3 syphilis 30.0 TPR IL17A CRP CD4 ALB
4 aspiration pneumonia 29.9 CRP CD4 ALB
5 stroke, ischemic 10.4
6 cardiovascular syphilis 10.4 TPR TCHH
7 early yaws 10.3 TPR CD4
8 asymptomatic neurosyphilis 10.3 CXCL13 CD4
9 cork-handlers' disease 10.3 CD4 ALB
10 internuclear ophthalmoplegia 10.3 PNMA2 MBP
11 acute necrotizing encephalitis 10.3 MBP LGI1
12 gastroduodenitis 10.3 CD4 ALB
13 latent syphilis 10.3 TPR CXCL13 CD4
14 central pontine myelinolysis 10.2 MBP ALB
15 recurrent hypersomnia 10.2 PNMA2 LGI1
16 primary syphilis 10.2 TPR RPSA CD4
17 immune deficiency disease 10.2
18 hemiplegia 10.2
19 tick-borne encephalitis 10.2 RPSA CXCL13 CD4
20 kleine-levin hibernation syndrome 10.2 PNMA2 LGI1
21 dipetalonemiasis 10.2 MT-CO1 ALB
22 capillariasis 10.2 MT-CO1 ALB
23 akinetic mutism 10.2 PNMA2 MBP LGI1
24 auditory agnosia 10.2 LGI1 CNTNAP2
25 anti-basement membrane glomerulonephritis 10.2 CD4 ALB
26 transient global amnesia 10.2 LGI1 CNTNAP2
27 testicular disease 10.1 PNMA2 CD4 ALB
28 dissociative amnesia 10.1 LGI1 CNTNAP2
29 neuromuscular junction disease 10.1 PNMA2 LGI1 AMPH
30 tabes dorsalis 10.1 TTPA TCHH CXCL13 CD4
31 myelitis 10.1 MBP IL17A AMPH
32 transient arthritis 10.1 IL17A CD4
33 chorea gravidarum 10.1 LGI1 CNTNAP2 AMPH
34 cystoisosporiasis 10.1 MT-CO1 CD4
35 lingual-facial-buccal dyskinesia 10.1 PNMA2 LGI1 CNTNAP2
36 von economo's disease 10.1 LGI1 CNTNAP2
37 polyradiculoneuropathy 10.1 MBP IL17A ALB
38 guillain-barre syndrome 10.1 MBP IL17A ALB
39 autoimmune neuropathy 10.1 LGI1 CNTNAP2 CD4
40 progressive relapsing multiple sclerosis 10.1 MBP IL17A CD4
41 cutaneous candidiasis 10.1 IL17RA IL17A
42 moyamoya disease 1 10.1
43 polysubstance abuse 10.1
44 aphasia 10.1
45 thrombosis 10.1
46 amnestic disorder 10.1
47 vertebral artery occlusion 10.1
48 dementia 10.1
49 central nervous system origin vertigo 10.1
50 cerebrovascular disease 10.1

Graphical network of the top 20 diseases related to Meningovascular Neurosyphilis:



Diseases related to Meningovascular Neurosyphilis

Symptoms & Phenotypes for Meningovascular Neurosyphilis

Symptoms:

11
  • headache
  • neck stiffness
  • dizziness
  • behavioral abnormalities
  • memory loss
  • insomnia
  • blurred vision
  • weakness
  • slowly progressive leg weakness
  • paralysis of the legs due to thrombosis of spinal arteries

Drugs & Therapeutics for Meningovascular Neurosyphilis

Search Clinical Trials, NIH Clinical Center for Meningovascular Neurosyphilis

Genetic Tests for Meningovascular Neurosyphilis

Anatomical Context for Meningovascular Neurosyphilis

Organs/tissues related to Meningovascular Neurosyphilis:

FMA: Arteries Of The Brain, Arteries Of Spinal Cord
MalaCards : Spinal Cord, Brain

Publications for Meningovascular Neurosyphilis

Articles related to Meningovascular Neurosyphilis:

(show all 37)
# Title Authors PMID Year
1
Neurosyphilis mimicking giant cell arteritis both clinically and microscopically. 62
35641087 2022
2
The Clinical Utility of High-Resolution Vessel Wall Imaging in Screening for Meningovascular Neurosyphilis. 62
34950388 2022
3
Serial Radiological Findings in Meningovascular Neurosyphilis Presenting as Acute Ischemic Stroke: A Case Report. 62
34500200 2021
4
Appearance of Meningovascular Neurosyphilis Causing an Acute Ischemic Stroke. 62
33165212 2021
5
Rapidly Progressing Moyamoya Syndrome Secondary to Meningovascular Neurosyphilis and Acquired Immunodeficiency Syndrome. 62
34367757 2021
6
Small vessel occlusion and syphilis in patients with first-ever ischemic stroke. 62
33759975 2021
7
German guidelines on the diagnosis and treatment of neurosyphilis. 62
33225223 2020
8
Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series. 62
29972419 2018
9
Meningovascular neurosyphilis with basilar artery thrombosis in HIV patient. 62
28993174 2018
10
Neurosyphilis Masquerading as Stroke in an 84-year-old. 62
29967874 2017
11
Prevalence of positive syphilis serology and meningovascular neurosyphilis in patients admitted with stroke and TIA from a culturally diverse population (2005-09). 62
23669171 2013
12
Spectrum and characterization of movement disorders secondary to neurosyphilis. 62
23395216 2013
13
Ischemic stroke as a primary symptom of neurosyphilis among HIV-negative emergency patients. 62
22482824 2012
14
[Meningovascular neurosyphilis with basilar artery thrombosis, a case report and literature review]. 62
23235782 2012
15
[Meningovascular neurosyphilis as the cause of ischemic cerebrovascular disease in a young man]. 62
21498167 2011
16
Amnestic syndrome due to meningovascular neurosyphilis. 62
19997924 2010
17
Meningovascular neurosyphilis: a report of stroke in a young adult. 62
20571297 2010
18
[Concentration of benzylpenicillin sodium salt in the cerebrospinal fluid of patients with late neurosyphilis as an indicator of efficacy of specific therapy]. 62
19491815 2009
19
[Meningovascular neurosyphilis]. 62
17688870 2007
20
[Autopsy case of meningovascular neurosyphilis associated with Fischer's plaques]. 62
17663152 2007
21
Intrathecal IgA synthesis in neurosyphilis. 62
15607206 2005
22
[Neurosyphilis presenting the left total ophthalmoplegia: a case report]. 62
15287513 2004
23
[Diagnosis and biological monitoring of 6 neurosyphilis cases: value of cerebrospinal fluid analysis]. 62
14671754 2003
24
[Neurosyphilis: forms of presentation and clinical management]. 62
12235572 2002
25
Dementia following an acute presentation of meningovascular neurosyphilis in an HIV-1 positive patient. 62
10997420 2000
26
[Neurosyphilis 12 years after treatment of primary infection in a meanwhile HIV infected patient]. 62
9289822 1997
27
Magnetic resonance angiography in meningovascular syphilis. 62
8041441 1994
28
Reactivity of locally produced CSF antibodies in patients with neurosyphilis against antigens of Treponema pallidum. 62
8263552 1993
29
[Bilateral internal carotid artery stenoses in a patient with meningovascular neurosyphilis]. 62
8261700 1993
30
Meningovascular neurosyphilis in human immunodeficiency virus infection as a differential diagnosis of focal CNS lesions: a clinicopathological study. 62
8370947 1993
31
Pure motor hemiplegia due to meningovascular neurosyphilis. 62
3632380 1987
32
[Intravenous penicillin therapy in high doses in neurosyphilis: study of 62 cases. I. Clinical evaluation]. 62
3322242 1987
33
Ischemic cerebrovascular disease in the young. Two common causes in India. 62
6464068 1984
34
Symptomatic neurosyphilis. 62
6662603 1983
35
[Myelin basic protein in cerebrospinal fluid in neurosyphilis (author's transl)]. 62
6159144 1980
36
[Meningovascular neurosyphilis. Report of a case with radiographically verified cerebral angiopathy]. 62
595192 1977
37
Poikiloderma atrophicans vasculare Jacobi; cutaneous changes typical of this disease in a patient with late meningovascular neurosyphilis. 62
21026343 1946

Variations for Meningovascular Neurosyphilis

Expression for Meningovascular Neurosyphilis

Search GEO for disease gene expression data for Meningovascular Neurosyphilis.

Pathways for Meningovascular Neurosyphilis

Pathways related to Meningovascular Neurosyphilis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.76 IL17RA IL17A CD4

GO Terms for Meningovascular Neurosyphilis

Biological processes related to Meningovascular Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-23 production GO:0032747 9.46 IL17RA IL17A
2 positive regulation of chemokine (C-X-C motif) ligand 1 production GO:2000340 9.26 IL17RA IL17A
3 fibroblast activation GO:0072537 8.92 IL17RA IL17A

Sources for Meningovascular Neurosyphilis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....