Meningovascular Neurosyphilis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Meningovascular Neurosyphilis

MalaCards integrated aliases for Meningovascular Neurosyphilis:

Name: Meningovascular Neurosyphilis ¹¹ ¹⁴

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0050491

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Summaries for Meningovascular Neurosyphilis

Disease Ontology: ¹¹ A tertiary neurosyphilis that results in inflammation located in arteries of the brain or located in arteries of spinal cord. The infection has symptom headache, has symptom neck stiffness, has symptom dizziness, has symptom behavioral abnormalities, has symptom poor concentration, has symptom memory loss, has symptom lassitude, has symptom insomnia, has symptom blurred vision, has symptom weakness and wasting of shoulder-girdle and arm muscles, has symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has symptom paralysis of the legs due to thrombosis of spinal arteries.

MalaCards based summary: Meningovascular Neurosyphilis is related to neurosyphilis and acquired immunodeficiency syndrome, and has symptoms including insomnia, headache and blurred vision. An important gene associated with Meningovascular Neurosyphilis is CXCL13 (C-X-C Motif Chemokine Ligand 13), and among its related pathways/superpathways are Th17 Differentiation and Endothelial cell senescence. Affiliated tissues include arteries of the brain, arteries of spinal cord and spinal cord.

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Related Diseases for Meningovascular Neurosyphilis

Diseases related to Meningovascular Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 365)

#	Related Disease	Score	Top Affiliating Genes
1	neurosyphilis	32.5	IL17A CXCL13
2	acquired immunodeficiency syndrome	30.0	MBP CRP CD4 ALB
3	syphilis	30.0	TPR IL17A CRP CD4 ALB
4	aspiration pneumonia	29.9	CRP CD4 ALB
5	stroke, ischemic	10.4
6	cardiovascular syphilis	10.4	TPR TCHH
7	early yaws	10.3	TPR CD4
8	asymptomatic neurosyphilis	10.3	CXCL13 CD4
9	cork-handlers' disease	10.3	CD4 ALB
10	internuclear ophthalmoplegia	10.3	PNMA2 MBP
11	acute necrotizing encephalitis	10.3	MBP LGI1
12	gastroduodenitis	10.3	CD4 ALB
13	latent syphilis	10.3	TPR CXCL13 CD4
14	central pontine myelinolysis	10.2	MBP ALB
15	recurrent hypersomnia	10.2	PNMA2 LGI1
16	primary syphilis	10.2	TPR RPSA CD4
17	immune deficiency disease	10.2
18	hemiplegia	10.2
19	tick-borne encephalitis	10.2	RPSA CXCL13 CD4
20	kleine-levin hibernation syndrome	10.2	PNMA2 LGI1
21	dipetalonemiasis	10.2	MT-CO1 ALB
22	capillariasis	10.2	MT-CO1 ALB
23	akinetic mutism	10.2	PNMA2 MBP LGI1
24	auditory agnosia	10.2	LGI1 CNTNAP2
25	anti-basement membrane glomerulonephritis	10.2	CD4 ALB
26	transient global amnesia	10.2	LGI1 CNTNAP2
27	testicular disease	10.1	PNMA2 CD4 ALB
28	dissociative amnesia	10.1	LGI1 CNTNAP2
29	neuromuscular junction disease	10.1	PNMA2 LGI1 AMPH
30	tabes dorsalis	10.1	TTPA TCHH CXCL13 CD4
31	myelitis	10.1	MBP IL17A AMPH
32	transient arthritis	10.1	IL17A CD4
33	chorea gravidarum	10.1	LGI1 CNTNAP2 AMPH
34	cystoisosporiasis	10.1	MT-CO1 CD4
35	lingual-facial-buccal dyskinesia	10.1	PNMA2 LGI1 CNTNAP2
36	von economo's disease	10.1	LGI1 CNTNAP2
37	polyradiculoneuropathy	10.1	MBP IL17A ALB
38	guillain-barre syndrome	10.1	MBP IL17A ALB
39	autoimmune neuropathy	10.1	LGI1 CNTNAP2 CD4
40	progressive relapsing multiple sclerosis	10.1	MBP IL17A CD4
41	cutaneous candidiasis	10.1	IL17RA IL17A
42	moyamoya disease 1	10.1
43	polysubstance abuse	10.1
44	aphasia	10.1
45	thrombosis	10.1
46	amnestic disorder	10.1
47	vertebral artery occlusion	10.1
48	dementia	10.1
49	cerebrovascular disease	10.1
50	vasculitis	10.1

Graphical network of the top 20 diseases related to Meningovascular Neurosyphilis:

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Symptoms & Phenotypes for Meningovascular Neurosyphilis

Symptoms:

¹¹

• insomnia
• headache
• blurred vision
• memory loss
• dizziness

• weakness
• neck stiffness
• behavioral abnormalities
• slowly progressive leg weakness
• paralysis of the legs due to thrombosis of spinal arteries

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Drugs & Therapeutics for Meningovascular Neurosyphilis

Search Clinical Trials, NIH Clinical Center for Meningovascular Neurosyphilis

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Genetic Tests for Meningovascular Neurosyphilis

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Anatomical Context for Meningovascular Neurosyphilis

Organs/tissues related to Meningovascular Neurosyphilis:

FMA: Arteries Of The Brain, Arteries Of Spinal Cord

MalaCards : Spinal Cord, Brain

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Publications for Meningovascular Neurosyphilis

Articles related to Meningovascular Neurosyphilis:

(show all 37)

#	Title	Authors	PMID	Year
1	Neurosyphilis mimicking giant cell arteritis both clinically and microscopically. ⁶²	van Ruitenbeek N...Bouma-de Krijger A	35641087	2022
2	The Clinical Utility of High-Resolution Vessel Wall Imaging in Screening for Meningovascular Neurosyphilis. ⁶²	Kayyali MN...Dumitrascu OM	34950388	2022
3	Serial Radiological Findings in Meningovascular Neurosyphilis Presenting as Acute Ischemic Stroke: A Case Report. ⁶²	Inui R...Kawamoto M	34500200	2021
4	Appearance of Meningovascular Neurosyphilis Causing an Acute Ischemic Stroke. ⁶²	Andreae A...Dicks K	33165212	2021
5	Rapidly Progressing Moyamoya Syndrome Secondary to Meningovascular Neurosyphilis and Acquired Immunodeficiency Syndrome. ⁶²	Wilson BC...Ezzeldin M	34367757	2021
6	Small vessel occlusion and syphilis in patients with first-ever ischemic stroke. ⁶²	Ferreira MG...Lange MC	33759975	2021
7	German guidelines on the diagnosis and treatment of neurosyphilis. ⁶²	Klein M...Weber J	33225223	2020
8	Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series. ⁶²	Borges CR...Teive HAG	29972419	2018
9	Meningovascular neurosyphilis with basilar artery thrombosis in HIV patient. ⁶²	Perez Barragan E...Sanchez Gonzalez M	28993174	2018
10	Neurosyphilis Masquerading as Stroke in an 84-year-old. ⁶²	Bologa C...Luca C	29967874	2017
11	Prevalence of positive syphilis serology and meningovascular neurosyphilis in patients admitted with stroke and TIA from a culturally diverse population (2005-09). ⁶²	Cordato DJ...McDougall AJ	23669171	2013
12	Spectrum and characterization of movement disorders secondary to neurosyphilis. ⁶²	Tong ML...Yang TC	23395216	2013
13	Ischemic stroke as a primary symptom of neurosyphilis among HIV-negative emergency patients. ⁶²	Liu LL...Yang TC	22482824	2012
14	[Meningovascular neurosyphilis with basilar artery thrombosis, a case report and literature review]. ⁶²	Jimenez JA...Ochoa JA	23235782	2012
15	[Meningovascular neurosyphilis as the cause of ischemic cerebrovascular disease in a young man]. ⁶²	Toth V...Karpati S	21498167	2011
16	Amnestic syndrome due to meningovascular neurosyphilis. ⁶²	Kearney H...O'Rourke K	19997924	2010
17	Meningovascular neurosyphilis: a report of stroke in a young adult. ⁶²	Vaitkus A...Urbonaviciute I	20571297	2010
18	[Concentration of benzylpenicillin sodium salt in the cerebrospinal fluid of patients with late neurosyphilis as an indicator of efficacy of specific therapy]. ⁶²	Rodikov MV...Rudnev VA	19491815	2009
19	[Meningovascular neurosyphilis]. ⁶²	Adeva Bartolome MT...Hernandez Bayo JM	17688870	2007
20	[Autopsy case of meningovascular neurosyphilis associated with Fischer's plaques]. ⁶²	Obi K...Akiyama H	17663152	2007
21	Intrathecal IgA synthesis in neurosyphilis. ⁶²	Ebinger M...Uhr M	15607206	2005
22	[Neurosyphilis presenting the left total ophthalmoplegia: a case report]. ⁶²	Takakura Y...Miyoshi T	15287513	2004
23	[Diagnosis and biological monitoring of 6 neurosyphilis cases: value of cerebrospinal fluid analysis]. ⁶²	Caudie C...Vandenberghe N	14671754	2003
24	[Neurosyphilis: forms of presentation and clinical management]. ⁶²	Conde-Sendin MA...Amela-Peris R	12235572	2002
25	Dementia following an acute presentation of meningovascular neurosyphilis in an HIV-1 positive patient. ⁶²	Fox PA...Dawson S	10997420	2000
26	[Neurosyphilis 12 years after treatment of primary infection in a meanwhile HIV infected patient]. ⁶²	Eriksson U...Frick H	9289822	1997
27	Magnetic resonance angiography in meningovascular syphilis. ⁶²	Gallego J...Villanueva JA	8041441	1994
28	Reactivity of locally produced CSF antibodies in patients with neurosyphilis against antigens of Treponema pallidum. ⁶²	Bollensen E...Prange HW	8263552	1993
29	[Bilateral internal carotid artery stenoses in a patient with meningovascular neurosyphilis]. ⁶²	Ohya Y...Shiozawa R	8261700	1993
30	Meningovascular neurosyphilis in human immunodeficiency virus infection as a differential diagnosis of focal CNS lesions: a clinicopathological study. ⁶²	Peters M...Ruf B	8370947	1993
31	Pure motor hemiplegia due to meningovascular neurosyphilis. ⁶²	Johns DR...Parker SW	3632380	1987
32	[Intravenous penicillin therapy in high doses in neurosyphilis: study of 62 cases. I. Clinical evaluation]. ⁶²	Nitrini R...Spina-Franca A	3322242	1987
33	Ischemic cerebrovascular disease in the young. Two common causes in India. ⁶²	Srinivasan K	6464068	1984
34	Symptomatic neurosyphilis. ⁶²	Lee JB...Choi IS	6662603	1983
35	[Myelin basic protein in cerebrospinal fluid in neurosyphilis (author's transl)]. ⁶²	Prange H...Ritter G	6159144	1980
36	[Meningovascular neurosyphilis. Report of a case with radiographically verified cerebral angiopathy]. ⁶²	Mondrup K...Thogersen G	595192	1977
37	Poikiloderma atrophicans vasculare Jacobi; cutaneous changes typical of this disease in a patient with late meningovascular neurosyphilis. ⁶²	KALZ F...HOOGSTRATEN J	21026343	1946

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Genes for Meningovascular Neurosyphilis

Genes related to Meningovascular Neurosyphilis (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CXCL13	C-X-C Motif Chemokine Ligand 13	Protein Coding	4.67	DISEASES inferred ¹⁴
2	TPR	Translocated Promoter Region, Nuclear Basket Protein	Protein Coding	4.45	DISEASES inferred ¹⁴
3	MBP	Myelin Basic Protein	Protein Coding	4.23	DISEASES inferred ¹⁴
4	TCHH	Trichohyalin	Protein Coding	4.15	DISEASES inferred ¹⁴
5	TTPA	Alpha Tocopherol Transfer Protein	Protein Coding	4.08	DISEASES inferred ¹⁴
6	ALB	Albumin	Protein Coding	3.98	DISEASES inferred ¹⁴
7	RPSA	Ribosomal Protein SA	Protein Coding	3.88	DISEASES inferred ¹⁴
8	AMPH	Amphiphysin	Protein Coding	3.58	DISEASES inferred ¹⁴
9	PNMA2	PNMA Family Member 2	Protein Coding	3.58	DISEASES inferred ¹⁴
10	CD82	CD82 Molecule	Protein Coding	3.51	DISEASES inferred ¹⁴
11	CD4	CD4 Molecule	Protein Coding	3.5	DISEASES inferred ¹⁴
12	LGI1	Leucine Rich Glioma Inactivated 1	Protein Coding	3.48	DISEASES inferred ¹⁴
13	CNTNAP2	Contactin Associated Protein 2	Protein Coding	3.36	DISEASES inferred ¹⁴
14	CD59	CD59 Molecule (CD59 Blood Group)	Protein Coding	3.3	DISEASES inferred ¹⁴
15	IL17RA	Interleukin 17 Receptor A	Protein Coding	3.27	DISEASES inferred ¹⁴
16	IL17A	Interleukin 17A	Protein Coding	3.17	DISEASES inferred ¹⁴
17	GAD2	Glutamate Decarboxylase 2	Protein Coding	3.07	DISEASES inferred ¹⁴
18	CRP	C-Reactive Protein	Protein Coding	3.05	DISEASES inferred ¹⁴
19	MT-CO1	Mitochondrially Encoded Cytochrome C Oxidase I	Protein Coding	3.04	DISEASES inferred ¹⁴

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Variations for Meningovascular Neurosyphilis

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Expression for Meningovascular Neurosyphilis

Search GEO for disease gene expression data for Meningovascular Neurosyphilis.

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Pathways for Meningovascular Neurosyphilis

Pathways related to Meningovascular Neurosyphilis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.09	IL17RA IL17A CD4
2	Endothelial cell senescence ⁷⁴	9.32	IL17RA IL17A

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GO Terms for Meningovascular Neurosyphilis

Biological processes related to Meningovascular Neurosyphilis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of interleukin-23 production	GO:0032747	9.46	IL17RA IL17A
2	positive regulation of chemokine (C-X-C motif) ligand 1 production	GO:2000340	9.26	IL17RA IL17A
3	fibroblast activation	GO:0072537	8.92	IL17RA IL17A

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Sources for Meningovascular Neurosyphilis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: MNN005 MIFTS: 28	Meningovascular Neurosyphilis Categories: Infectious diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
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