Meningovascular Neurosyphilis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MNN005 MIFTS: 31	Meningovascular Neurosyphilis Categories: Infectious diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Meningovascular Neurosyphilis

MalaCards integrated aliases for Meningovascular Neurosyphilis:

Name: Meningovascular Neurosyphilis ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050491

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Summaries for Meningovascular Neurosyphilis

Disease Ontology : ¹² A tertiary neurosyphilis that results in inflammation located in arteries of the brain or located in arteries of spinal cord. The infection has symptom headache, has symptom neck stiffness, has symptom dizziness, has symptom behavioral abnormalities, has symptom poor concentration, has symptom memory loss, has symptom lassitude, has symptom insomnia, has symptom blurred vision, has symptom weakness and wasting of shoulder-girdle and arm muscles, has symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has symptom paralysis of the legs due to thrombosis of spinal arteries.

MalaCards based summary : Meningovascular Neurosyphilis is related to neurosyphilis and asymptomatic neurosyphilis, and has symptoms including insomnia, headache and blurred vision. An important gene associated with Meningovascular Neurosyphilis is CXCL13 (C-X-C Motif Chemokine Ligand 13), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. Affiliated tissues include arteries of the brain, arteries of spinal cord and spinal cord, and related phenotype is immune system.

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Related Diseases for Meningovascular Neurosyphilis

Diseases related to Meningovascular Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 521)

#	Related Disease	Score	Top Affiliating Genes
1	neurosyphilis	32.4	IL17A CXCL13
2	asymptomatic neurosyphilis	30.8	IL17A CXCL13 CD4
3	vascular dementia	29.7	TNF MBP CRP
4	stroke, ischemic	29.4	TNF MBP CRP ALB
5	syphilis	29.3	TNF IL17A CRP CD4 ALB
6	aspiration pneumonia	29.3	TNF IL17A CRP ALB
7	vascular disease	29.2	TNF CRP CD4 ALB
8	acquired immunodeficiency syndrome	29.0	TNF MBP CRP CD4 ALB
9	postinfectious encephalitis	10.3	MBP CXCL13
10	central pontine myelinolysis	10.3	MBP ALB
11	thrombosis	10.2
12	hemiplegia	10.2
13	cutaneous candidiasis	10.2	IL17RA IL17A
14	brain injury	10.2	MBP ALB
15	latent syphilis	10.2	CXCL13 CD4
16	jejunoileitis	10.2	TNF ALB
17	peptic esophagitis	10.2	TNF ALB
18	cork-handlers' disease	10.2	CD4 ALB
19	riedel's fibrosing thyroiditis	10.2	CD4 ALB
20	pasteurellosis	10.1	TNF ALB
21	miller fisher syndrome	10.1	TNF ALB
22	polyradiculopathy	10.1	MBP CD4
23	angular cheilitis	10.1	CD4 ALB
24	palladium allergic contact dermatitis	10.1	TNF IL17A
25	anti-basement membrane glomerulonephritis	10.1	CD4 ALB
26	marasmus	10.1	CD4 ALB
27	parenchymatous neurosyphilis	10.1	TCHH MBP CD59
28	bell's palsy	10.1	CD4 ALB
29	chemical colitis	10.1	TNF IL17A
30	immunodeficiency 43	10.1	CD4 ALB
31	arthus reaction	10.1	TNF ALB
32	babesiosis	10.1	CD4 ALB
33	gummatous syphilis	10.1	TCHH CRP
34	type 1 diabetes mellitus 23	10.1	TNF CD4
35	aphasia	10.1
36	cerebrovascular disease	10.1
37	toxoplasmosis	10.1
38	transient pseudohypoaldosteronism	10.1
39	norwegian scabies	10.0	IL17A CD4
40	transient arthritis	10.0	IL17A CD4
41	skin sarcoidosis	10.0	TNF CD4
42	periapical periodontitis	10.0	TNF IL17A
43	metal allergy	10.0	IL17A CD4
44	chronic duodenal ileus	10.0	CRP ALB
45	acute retrobulbar neuritis	10.0	MBP CRP
46	granuloma annulare	10.0	TNF CD4
47	polyradiculoneuropathy	10.0	MBP IL17A ALB
48	granulomatous angiitis	10.0	MBP CRP
49	central nervous system tuberculosis	10.0	TNF CD4
50	tabes dorsalis	10.0	TCHH CXCL13 CD4

Graphical network of the top 20 diseases related to Meningovascular Neurosyphilis:

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Symptoms & Phenotypes for Meningovascular Neurosyphilis

Symptoms:

¹²

• insomnia
• headache
• blurred vision
• memory loss
• dizziness

• weakness
• neck stiffness
• behavioral abnormalities
• slowly progressive leg weakness
• paralysis of the legs due to thrombosis of spinal arteries

MGI Mouse Phenotypes related to Meningovascular Neurosyphilis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.23	ALB CD4 CRP CXCL13 IL17A IL17RA

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Drugs & Therapeutics for Meningovascular Neurosyphilis

Search Clinical Trials , NIH Clinical Center for Meningovascular Neurosyphilis

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Genetic Tests for Meningovascular Neurosyphilis

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Anatomical Context for Meningovascular Neurosyphilis

The Foundational Model of Anatomy Ontology organs/tissues related to Meningovascular Neurosyphilis:

¹⁹

Arteries Of The Brain, Arteries Of Spinal Cord

MalaCards organs/tissues related to Meningovascular Neurosyphilis:

⁴⁰

Spinal Cord

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Publications for Meningovascular Neurosyphilis

Articles related to Meningovascular Neurosyphilis:

(show all 33)

#	Title	Authors	PMID	Year
1	Small vessel occlusion and syphilis in patients with first-ever ischemic stroke. ⁶¹	Ferreira MG...Lange MC	33759975	2021
2	Appearance of Meningovascular Neurosyphilis Causing an Acute Ischemic Stroke. ⁶¹	Andreae A...Dicks K	33165212	2020
3	German guidelines on the diagnosis and treatment of neurosyphilis. ⁶¹	Klein M...Weber J	33225223	2020
4	Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series. ⁶¹	Borges CR...Teive HAG	29972419	2018
5	Meningovascular neurosyphilis with basilar artery thrombosis in HIV patient. ⁶¹	Perez Barragan E...Sanchez Gonzalez M	28993174	2018
6	Neurosyphilis Masquerading as Stroke in an 84-year-old. ⁶¹	Bologa C...Luca C	29967874	2017
7	Prevalence of positive syphilis serology and meningovascular neurosyphilis in patients admitted with stroke and TIA from a culturally diverse population (2005-09). ⁶¹	Cordato DJ...McDougall AJ	23669171	2013
8	Spectrum and characterization of movement disorders secondary to neurosyphilis. ⁶¹	Tong ML...Yang TC	23395216	2013
9	Ischemic stroke as a primary symptom of neurosyphilis among HIV-negative emergency patients. ⁶¹	Liu LL...Yang TC	22482824	2012
10	[Meningovascular neurosyphilis with basilar artery thrombosis, a case report and literature review]. ⁶¹	Jimenez JA...Ochoa JA	23235782	2012
11	[Meningovascular neurosyphilis as the cause of ischemic cerebrovascular disease in a young man]. ⁶¹	Toth V...Karpati S	21498167	2011
12	Amnestic syndrome due to meningovascular neurosyphilis. ⁶¹	Kearney H...O'Rourke K	19997924	2010
13	Meningovascular neurosyphilis: a report of stroke in a young adult. ⁶¹	Vaitkus A...Urbonaviciute I	20571297	2010
14	[Concentration of benzylpenicillin sodium salt in the cerebrospinal fluid of patients with late neurosyphilis as an indicator of efficacy of specific therapy]. ⁶¹	Rodikov MV...Rudnev VA	19491815	2009
15	[Meningovascular neurosyphilis]. ⁶¹	Adeva Bartolome MT...Hernandez Bayo JM	17688870	2007
16	[Autopsy case of meningovascular neurosyphilis associated with Fischer's plaques]. ⁶¹	Obi K...Akiyama H	17663152	2007
17	Intrathecal IgA synthesis in neurosyphilis. ⁶¹	Ebinger M...Uhr M	15607206	2005
18	[Neurosyphilis presenting the left total ophthalmoplegia: a case report]. ⁶¹	Takakura Y...Miyoshi T	15287513	2004
19	[Diagnosis and biological monitoring of 6 neurosyphilis cases: value of cerebrospinal fluid analysis]. ⁶¹	Caudie C...Vandenberghe N	14671754	2003
20	[Neurosyphilis: forms of presentation and clinical management]. ⁶¹	Conde-Sendin MA...Amela-Peris R	12235572	2002
21	Dementia following an acute presentation of meningovascular neurosyphilis in an HIV-1 positive patient. ⁶¹	Fox PA...Dawson S	10997420	2000
22	[Neurosyphilis 12 years after treatment of primary infection in a meanwhile HIV infected patient]. ⁶¹	Eriksson U...Frick H	9289822	1997
23	Magnetic resonance angiography in meningovascular syphilis. ⁶¹	Gallego J...Villanueva JA	8041441	1994
24	Reactivity of locally produced CSF antibodies in patients with neurosyphilis against antigens of Treponema pallidum. ⁶¹	Bollensen E...Prange HW	8263552	1993
25	[Bilateral internal carotid artery stenoses in a patient with meningovascular neurosyphilis]. ⁶¹	Ohya Y...Shiozawa R	8261700	1993
26	Meningovascular neurosyphilis in human immunodeficiency virus infection as a differential diagnosis of focal CNS lesions: a clinicopathological study. ⁶¹	Peters M...Ruf B	8370947	1993
27	Pure motor hemiplegia due to meningovascular neurosyphilis. ⁶¹	Johns DR...Parker SW	3632380	1987
28	[Intravenous penicillin therapy in high doses in neurosyphilis: study of 62 cases. I. Clinical evaluation]. ⁶¹	Nitrini R...Spina-Franca A	3322242	1987
29	Ischemic cerebrovascular disease in the young. Two common causes in India. ⁶¹	Srinivasan K	6464068	1984
30	Symptomatic neurosyphilis. ⁶¹	Lee JB...Choi IS	6662603	1983
31	[Myelin basic protein in cerebrospinal fluid in neurosyphilis (author's transl)]. ⁶¹	Prange H...Ritter G	6159144	1980
32	[Meningovascular neurosyphilis. Report of a case with radiographically verified cerebral angiopathy]. ⁶¹	Mondrup K...Thogersen G	595192	1977
33	Poikiloderma atrophicans vasculare Jacobi; cutaneous changes typical of this disease in a patient with late meningovascular neurosyphilis. ⁶¹	KALZ F...HOOGSTRATEN J	21026343	1946

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Genes for Meningovascular Neurosyphilis

Genes related to Meningovascular Neurosyphilis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CXCL13	C-X-C Motif Chemokine Ligand 13	Protein Coding	5.08	DISEASES inferred ¹⁵
2	TCHH	Trichohyalin	Protein Coding	4.83	DISEASES inferred ¹⁵
3	MBP	Myelin Basic Protein	Protein Coding	4.82	DISEASES inferred ¹⁵
4	ALB	Albumin	Protein Coding	4.17	DISEASES inferred ¹⁵
5	IL17RA	Interleukin 17 Receptor A	Protein Coding	4.02	DISEASES inferred ¹⁵
6	CD59	CD59 Molecule (CD59 Blood Group)	Protein Coding	4	DISEASES inferred ¹⁵
7	IL17A	Interleukin 17A	Protein Coding	3.94	DISEASES inferred ¹⁵
8	CD4	CD4 Molecule	Protein Coding	3.72	DISEASES inferred ¹⁵
9	CRP	C-Reactive Protein	Protein Coding	3.49	DISEASES inferred ¹⁵
10	TNF	Tumor Necrosis Factor	Protein Coding	3.31	DISEASES inferred ¹⁵

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Variations for Meningovascular Neurosyphilis

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Expression for Meningovascular Neurosyphilis

Search GEO for disease gene expression data for Meningovascular Neurosyphilis.

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Pathways for Meningovascular Neurosyphilis

Pathways related to Meningovascular Neurosyphilis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	12.92	TNF IL17RA IL17A CXCL13 CD4
2	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.48	TNF IL17A CXCL13 CD4
3	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.61	TNF CD59 CD4
4	Hematopoietic cell lineage ³⁶	11.49	TNF CD59 CD4
5	Th17 Differentiation Pathway ⁶⁴ Show member pathways IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴	11.39	IL17RA IL17A CD4
6	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.23	TNF IL17A CD4
7	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.01	TNF IL17A CD4
8	Cytokines and Inflammatory Response ¹	10.94	TNF CD4
9	Overview of nanoparticle effects ¹	10.68	TNF CRP
10	Dendritic Cells Developmental Lineage Pathway ⁶⁴	10.67	TNF IL17RA CD4

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GO Terms for Meningovascular Neurosyphilis

Cellular components related to Meningovascular Neurosyphilis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.43	TNF IL17A CXCL13 CRP CD59 ALB
2	extracellular region	GO:0005576	9.17	TNF IL17RA IL17A CXCL13 CRP CD59

Biological processes related to Meningovascular Neurosyphilis according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface receptor signaling pathway	GO:0007166	9.71	IL17RA CXCL13 CD59 CD4
2	defense response to Gram-positive bacterium	GO:0050830	9.67	TNF IL17A CRP
3	immune response	GO:0006955	9.55	TNF MBP IL17A CXCL13 CD4
4	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.52	TNF IL17A
5	positive regulation of osteoclast differentiation	GO:0045672	9.51	TNF IL17A
6	positive regulation of chemokine (C-X-C motif) ligand 2 production	GO:2000343	9.48	TNF MBP
7	interleukin-17-mediated signaling pathway	GO:0097400	9.46	IL17RA IL17A
8	negative regulation of lipid storage	GO:0010888	9.43	TNF CRP
9	positive regulation of chemokine (C-X-C motif) ligand 1 production	GO:2000340	9.37	IL17RA IL17A
10	inflammatory response	GO:0006954	9.35	TNF IL17RA IL17A CXCL13 CRP
11	positive regulation of interleukin-23 production	GO:0032747	9.32	IL17RA IL17A
12	fibroblast activation	GO:0072537	9.26	IL17RA IL17A
13	positive regulation of interleukin-6 production	GO:0032755	8.92	TNF MBP IL17RA IL17A

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Sources for Meningovascular Neurosyphilis

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