MCID: MNN005
MIFTS: 31

Meningovascular Neurosyphilis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Meningovascular Neurosyphilis

MalaCards integrated aliases for Meningovascular Neurosyphilis:

Name: Meningovascular Neurosyphilis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050491

Summaries for Meningovascular Neurosyphilis

Disease Ontology : 12 A tertiary neurosyphilis that results in inflammation located in arteries of the brain or located in arteries of spinal cord. The infection has symptom headache, has symptom neck stiffness, has symptom dizziness, has symptom behavioral abnormalities, has symptom poor concentration, has symptom memory loss, has symptom lassitude, has symptom insomnia, has symptom blurred vision, has symptom weakness and wasting of shoulder-girdle and arm muscles, has symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has symptom paralysis of the legs due to thrombosis of spinal arteries.

MalaCards based summary : Meningovascular Neurosyphilis is related to neurosyphilis and asymptomatic neurosyphilis, and has symptoms including insomnia, headache and blurred vision. An important gene associated with Meningovascular Neurosyphilis is CXCL13 (C-X-C Motif Chemokine Ligand 13), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. Affiliated tissues include arteries of the brain, arteries of spinal cord and spinal cord, and related phenotype is immune system.

Related Diseases for Meningovascular Neurosyphilis

Diseases related to Meningovascular Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 521)
# Related Disease Score Top Affiliating Genes
1 neurosyphilis 32.4 IL17A CXCL13
2 asymptomatic neurosyphilis 30.8 IL17A CXCL13 CD4
3 vascular dementia 29.7 TNF MBP CRP
4 stroke, ischemic 29.4 TNF MBP CRP ALB
5 syphilis 29.3 TNF IL17A CRP CD4 ALB
6 aspiration pneumonia 29.3 TNF IL17A CRP ALB
7 vascular disease 29.2 TNF CRP CD4 ALB
8 acquired immunodeficiency syndrome 29.0 TNF MBP CRP CD4 ALB
9 postinfectious encephalitis 10.3 MBP CXCL13
10 central pontine myelinolysis 10.3 MBP ALB
11 thrombosis 10.2
12 hemiplegia 10.2
13 cutaneous candidiasis 10.2 IL17RA IL17A
14 brain injury 10.2 MBP ALB
15 latent syphilis 10.2 CXCL13 CD4
16 jejunoileitis 10.2 TNF ALB
17 peptic esophagitis 10.2 TNF ALB
18 cork-handlers' disease 10.2 CD4 ALB
19 riedel's fibrosing thyroiditis 10.2 CD4 ALB
20 pasteurellosis 10.1 TNF ALB
21 miller fisher syndrome 10.1 TNF ALB
22 polyradiculopathy 10.1 MBP CD4
23 angular cheilitis 10.1 CD4 ALB
24 palladium allergic contact dermatitis 10.1 TNF IL17A
25 anti-basement membrane glomerulonephritis 10.1 CD4 ALB
26 marasmus 10.1 CD4 ALB
27 parenchymatous neurosyphilis 10.1 TCHH MBP CD59
28 bell's palsy 10.1 CD4 ALB
29 chemical colitis 10.1 TNF IL17A
30 immunodeficiency 43 10.1 CD4 ALB
31 arthus reaction 10.1 TNF ALB
32 babesiosis 10.1 CD4 ALB
33 gummatous syphilis 10.1 TCHH CRP
34 type 1 diabetes mellitus 23 10.1 TNF CD4
35 aphasia 10.1
36 cerebrovascular disease 10.1
37 toxoplasmosis 10.1
38 transient pseudohypoaldosteronism 10.1
39 norwegian scabies 10.0 IL17A CD4
40 transient arthritis 10.0 IL17A CD4
41 skin sarcoidosis 10.0 TNF CD4
42 periapical periodontitis 10.0 TNF IL17A
43 metal allergy 10.0 IL17A CD4
44 chronic duodenal ileus 10.0 CRP ALB
45 acute retrobulbar neuritis 10.0 MBP CRP
46 granuloma annulare 10.0 TNF CD4
47 polyradiculoneuropathy 10.0 MBP IL17A ALB
48 granulomatous angiitis 10.0 MBP CRP
49 central nervous system tuberculosis 10.0 TNF CD4
50 tabes dorsalis 10.0 TCHH CXCL13 CD4

Graphical network of the top 20 diseases related to Meningovascular Neurosyphilis:



Diseases related to Meningovascular Neurosyphilis

Symptoms & Phenotypes for Meningovascular Neurosyphilis

Symptoms:

12
  • insomnia
  • headache
  • blurred vision
  • memory loss
  • dizziness
  • weakness
  • neck stiffness
  • behavioral abnormalities
  • slowly progressive leg weakness
  • paralysis of the legs due to thrombosis of spinal arteries

MGI Mouse Phenotypes related to Meningovascular Neurosyphilis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 ALB CD4 CRP CXCL13 IL17A IL17RA

Drugs & Therapeutics for Meningovascular Neurosyphilis

Search Clinical Trials , NIH Clinical Center for Meningovascular Neurosyphilis

Genetic Tests for Meningovascular Neurosyphilis

Anatomical Context for Meningovascular Neurosyphilis

The Foundational Model of Anatomy Ontology organs/tissues related to Meningovascular Neurosyphilis:

19
Arteries Of The Brain, Arteries Of Spinal Cord

MalaCards organs/tissues related to Meningovascular Neurosyphilis:

40
Spinal Cord

Publications for Meningovascular Neurosyphilis

Articles related to Meningovascular Neurosyphilis:

(show all 33)
# Title Authors PMID Year
1
Small vessel occlusion and syphilis in patients with first-ever ischemic stroke. 61
33759975 2021
2
Appearance of Meningovascular Neurosyphilis Causing an Acute Ischemic Stroke. 61
33165212 2020
3
German guidelines on the diagnosis and treatment of neurosyphilis. 61
33225223 2020
4
Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series. 61
29972419 2018
5
Meningovascular neurosyphilis with basilar artery thrombosis in HIV patient. 61
28993174 2018
6
Neurosyphilis Masquerading as Stroke in an 84-year-old. 61
29967874 2017
7
Prevalence of positive syphilis serology and meningovascular neurosyphilis in patients admitted with stroke and TIA from a culturally diverse population (2005-09). 61
23669171 2013
8
Spectrum and characterization of movement disorders secondary to neurosyphilis. 61
23395216 2013
9
Ischemic stroke as a primary symptom of neurosyphilis among HIV-negative emergency patients. 61
22482824 2012
10
[Meningovascular neurosyphilis with basilar artery thrombosis, a case report and literature review]. 61
23235782 2012
11
[Meningovascular neurosyphilis as the cause of ischemic cerebrovascular disease in a young man]. 61
21498167 2011
12
Amnestic syndrome due to meningovascular neurosyphilis. 61
19997924 2010
13
Meningovascular neurosyphilis: a report of stroke in a young adult. 61
20571297 2010
14
[Concentration of benzylpenicillin sodium salt in the cerebrospinal fluid of patients with late neurosyphilis as an indicator of efficacy of specific therapy]. 61
19491815 2009
15
[Meningovascular neurosyphilis]. 61
17688870 2007
16
[Autopsy case of meningovascular neurosyphilis associated with Fischer's plaques]. 61
17663152 2007
17
Intrathecal IgA synthesis in neurosyphilis. 61
15607206 2005
18
[Neurosyphilis presenting the left total ophthalmoplegia: a case report]. 61
15287513 2004
19
[Diagnosis and biological monitoring of 6 neurosyphilis cases: value of cerebrospinal fluid analysis]. 61
14671754 2003
20
[Neurosyphilis: forms of presentation and clinical management]. 61
12235572 2002
21
Dementia following an acute presentation of meningovascular neurosyphilis in an HIV-1 positive patient. 61
10997420 2000
22
[Neurosyphilis 12 years after treatment of primary infection in a meanwhile HIV infected patient]. 61
9289822 1997
23
Magnetic resonance angiography in meningovascular syphilis. 61
8041441 1994
24
Reactivity of locally produced CSF antibodies in patients with neurosyphilis against antigens of Treponema pallidum. 61
8263552 1993
25
[Bilateral internal carotid artery stenoses in a patient with meningovascular neurosyphilis]. 61
8261700 1993
26
Meningovascular neurosyphilis in human immunodeficiency virus infection as a differential diagnosis of focal CNS lesions: a clinicopathological study. 61
8370947 1993
27
Pure motor hemiplegia due to meningovascular neurosyphilis. 61
3632380 1987
28
[Intravenous penicillin therapy in high doses in neurosyphilis: study of 62 cases. I. Clinical evaluation]. 61
3322242 1987
29
Ischemic cerebrovascular disease in the young. Two common causes in India. 61
6464068 1984
30
Symptomatic neurosyphilis. 61
6662603 1983
31
[Myelin basic protein in cerebrospinal fluid in neurosyphilis (author's transl)]. 61
6159144 1980
32
[Meningovascular neurosyphilis. Report of a case with radiographically verified cerebral angiopathy]. 61
595192 1977
33
Poikiloderma atrophicans vasculare Jacobi; cutaneous changes typical of this disease in a patient with late meningovascular neurosyphilis. 61
21026343 1946

Variations for Meningovascular Neurosyphilis

Expression for Meningovascular Neurosyphilis

Search GEO for disease gene expression data for Meningovascular Neurosyphilis.

Pathways for Meningovascular Neurosyphilis

GO Terms for Meningovascular Neurosyphilis

Cellular components related to Meningovascular Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 TNF IL17A CXCL13 CRP CD59 ALB
2 extracellular region GO:0005576 9.17 TNF IL17RA IL17A CXCL13 CRP CD59

Biological processes related to Meningovascular Neurosyphilis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.71 IL17RA CXCL13 CD59 CD4
2 defense response to Gram-positive bacterium GO:0050830 9.67 TNF IL17A CRP
3 immune response GO:0006955 9.55 TNF MBP IL17A CXCL13 CD4
4 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.52 TNF IL17A
5 positive regulation of osteoclast differentiation GO:0045672 9.51 TNF IL17A
6 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.48 TNF MBP
7 interleukin-17-mediated signaling pathway GO:0097400 9.46 IL17RA IL17A
8 negative regulation of lipid storage GO:0010888 9.43 TNF CRP
9 positive regulation of chemokine (C-X-C motif) ligand 1 production GO:2000340 9.37 IL17RA IL17A
10 inflammatory response GO:0006954 9.35 TNF IL17RA IL17A CXCL13 CRP
11 positive regulation of interleukin-23 production GO:0032747 9.32 IL17RA IL17A
12 fibroblast activation GO:0072537 9.26 IL17RA IL17A
13 positive regulation of interleukin-6 production GO:0032755 8.92 TNF MBP IL17RA IL17A

Sources for Meningovascular Neurosyphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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