Meningovascular Neurosyphilis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MNN005 MIFTS: 26	Meningovascular Neurosyphilis Categories: Infectious diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Meningovascular Neurosyphilis

MalaCards integrated aliases for Meningovascular Neurosyphilis:

Name: Meningovascular Neurosyphilis ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050491

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Summaries for Meningovascular Neurosyphilis

Disease Ontology : ¹² A tertiary neurosyphilis that results in inflammation located in arteries of the brain or located in arteries of spinal cord. The infection has symptom headache, has symptom neck stiffness, has symptom dizziness, has symptom behavioral abnormalities, has symptom poor concentration, has symptom memory loss, has symptom lassitude, has symptom insomnia, has symptom blurred vision, has symptom weakness and wasting of shoulder-girdle and arm muscles, has symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has symptom paralysis of the legs due to thrombosis of spinal arteries.

MalaCards based summary : Meningovascular Neurosyphilis is related to neurosyphilis and asymptomatic neurosyphilis. An important gene associated with Meningovascular Neurosyphilis is CXCL13 (C-X-C Motif Chemokine Ligand 13), and among its related pathways/superpathways are PAK Pathway and Th17 Differentiation. Affiliated tissues include brain and spinal cord, and related phenotypes are hematopoietic system and immune system

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Related Diseases for Meningovascular Neurosyphilis

Diseases related to Meningovascular Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 418)

#	Related Disease	Score	Top Affiliating Genes
1	neurosyphilis	33.5	IL17A CXCL13
2	asymptomatic neurosyphilis	30.8	MYH9 CXCL13 CD40LG CD4
3	aspiration pneumonia	29.9	IL17A CRP CD40LG ALB
4	vascular disease	29.6	CRP CD40LG CD4 ALB
5	acquired immunodeficiency syndrome	29.4	MBP CRP CD40LG CD4 ALB
6	syphilis	29.2	MYH9 IL17A CRP CD40LG CD4 ALB
7	acute retrobulbar neuritis	10.4	MBP CD40LG
8	fournier gangrene	10.4	CD40LG ALB
9	heterophyiasis	10.4	CD40LG ALB
10	non-secretory myeloma	10.4	CD40LG ALB
11	yaws	10.4	MYH9 CD40LG
12	suppurative uveitis	10.3	IL17A CD40LG
13	thrombosis	10.3
14	hemiplegia	10.3
15	ocular toxoplasmosis	10.3	IL17A CD40LG
16	bile acid synthesis defect, congenital, 1	10.3	CD40LG ALB
17	anaerobic meningitis	10.3	MBP CRP
18	transverse myelitis	10.3	MBP IL17A
19	dysgammaglobulinemia	10.3	MBP CD40LG
20	calciphylaxis	10.3	CD40LG ALB
21	granulomatous angiitis	10.3	MBP CRP
22	japanese spotted fever	10.3	CRP CD40LG
23	chronic orbital inflammation	10.3	CRP CD40LG
24	chronic duodenal ileus	10.3	CRP ALB
25	ecthyma	10.3	CRP CD40LG
26	cutaneous candidiasis	10.2	IL17RA IL17A
27	epiglottitis	10.2	CRP CD40LG
28	viral laryngitis	10.2	CRP CD40LG
29	laryngitis	10.2	CRP CD40LG
30	tuberculous peritonitis	10.2	CRP ALB
31	peptic ulcer perforation	10.2	CRP ALB
32	ascending cholangitis	10.2	CRP ALB
33	ankylosing spondylitis 1	10.2	CRP ALB
34	critical illness polyneuropathy	10.2	CRP ALB
35	epidural abscess	10.2	CRP ALB
36	ornithosis	10.2	CRP CD40LG
37	late congenital syphilis	10.2	CRP CD40LG
38	guillain-barre syndrome	10.2	MBP CD40LG ALB
39	bacterial conjunctivitis	10.2	CRP CD40LG
40	duodenal obstruction	10.2	CRP ALB
41	ankylosing spondylitis 3	10.2	CRP ALB
42	american histoplasmosis	10.2	CD40LG CD4
43	eye lymphoma	10.2	CXCL13 CD4
44	inflammatory and toxic neuropathy	10.2	CRP ALB
45	generalized atherosclerosis	10.2	CRP ALB
46	early yaws	10.2	CD40LG CD4
47	tenosynovitis	10.2	CRP CD40LG
48	stroke, ischemic	10.2
49	aphasia	10.2
50	cerebrovascular disease	10.2

Graphical network of the top 20 diseases related to Meningovascular Neurosyphilis:

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Symptoms & Phenotypes for Meningovascular Neurosyphilis

MGI Mouse Phenotypes related to Meningovascular Neurosyphilis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.56	CD4 CD40LG CD59 CXCL13 IL17A IL17RA
2	immune system	MP:0005387	9.28	ALB CD4 CD40LG CRP CXCL13 IL17A

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Drugs & Therapeutics for Meningovascular Neurosyphilis

Search Clinical Trials , NIH Clinical Center for Meningovascular Neurosyphilis

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Genetic Tests for Meningovascular Neurosyphilis

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Anatomical Context for Meningovascular Neurosyphilis

MalaCards organs/tissues related to Meningovascular Neurosyphilis:

⁴⁰

Brain, Spinal Cord

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Publications for Meningovascular Neurosyphilis

Articles related to Meningovascular Neurosyphilis:

(show all 30)

#	Title	Authors	PMID	Year
1	Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series. ⁶¹	Borges CR...Teive HAG	29972419	2018
2	Meningovascular neurosyphilis with basilar artery thrombosis in HIV patient. ⁶¹	Perez Barragan E...Sanchez Gonzalez M	28993174	2018
3	Neurosyphilis Masquerading as Stroke in an 84-year-old. ⁶¹	Bologa C...Luca C	29967874	2017
4	Prevalence of positive syphilis serology and meningovascular neurosyphilis in patients admitted with stroke and TIA from a culturally diverse population (2005-09). ⁶¹	Cordato DJ...McDougall AJ	23669171	2013
5	Spectrum and characterization of movement disorders secondary to neurosyphilis. ⁶¹	Tong ML...Yang TC	23395216	2013
6	Ischemic stroke as a primary symptom of neurosyphilis among HIV-negative emergency patients. ⁶¹	Liu LL...Yang TC	22482824	2012
7	[Meningovascular neurosyphilis with basilar artery thrombosis, a case report and literature review]. ⁶¹	Jimenez JA...Ochoa JA	23235782	2012
8	[Meningovascular neurosyphilis as the cause of ischemic cerebrovascular disease in a young man]. ⁶¹	Toth V...Karpati S	21498167	2011
9	Amnestic syndrome due to meningovascular neurosyphilis. ⁶¹	Kearney H...O'Rourke K	19997924	2010
10	Meningovascular neurosyphilis: a report of stroke in a young adult. ⁶¹	Vaitkus A...Urbonaviciute I	20571297	2010
11	[Concentration of benzylpenicillin sodium salt in the cerebrospinal fluid of patients with late neurosyphilis as an indicator of efficacy of specific therapy]. ⁶¹	Rodikov MV...Rudnev VA	19491815	2009
12	[Meningovascular neurosyphilis]. ⁶¹	Adeva Bartolome MT...Hernandez Bayo JM	17688870	2007
13	[Autopsy case of meningovascular neurosyphilis associated with Fischer's plaques]. ⁶¹	Obi K...Akiyama H	17663152	2007
14	Intrathecal IgA synthesis in neurosyphilis. ⁶¹	Ebinger M...Uhr M	15607206	2005
15	[Neurosyphilis presenting the left total ophthalmoplegia: a case report]. ⁶¹	Takakura Y...Miyoshi T	15287513	2004
16	[Diagnosis and biological monitoring of 6 neurosyphilis cases: value of cerebrospinal fluid analysis]. ⁶¹	Caudie C...Vandenberghe N	14671754	2003
17	[Neurosyphilis: forms of presentation and clinical management]. ⁶¹	Conde-Sendin MA...Amela-Peris R	12235572	2002
18	Dementia following an acute presentation of meningovascular neurosyphilis in an HIV-1 positive patient. ⁶¹	Fox PA...Dawson S	10997420	2000
19	[Neurosyphilis 12 years after treatment of primary infection in a meanwhile HIV infected patient]. ⁶¹	Eriksson U...Frick H	9289822	1997
20	Magnetic resonance angiography in meningovascular syphilis. ⁶¹	Gallego J...Villanueva JA	8041441	1994
21	Reactivity of locally produced CSF antibodies in patients with neurosyphilis against antigens of Treponema pallidum. ⁶¹	Bollensen E...Prange HW	8263552	1993
22	[Bilateral internal carotid artery stenoses in a patient with meningovascular neurosyphilis]. ⁶¹	Ohya Y...Shiozawa R	8261700	1993
23	Meningovascular neurosyphilis in human immunodeficiency virus infection as a differential diagnosis of focal CNS lesions: a clinicopathological study. ⁶¹	Peters M...Ruf B	8370947	1993
24	Pure motor hemiplegia due to meningovascular neurosyphilis. ⁶¹	Johns DR...Parker SW	3632380	1987
25	[Intravenous penicillin therapy in high doses in neurosyphilis: study of 62 cases. I. Clinical evaluation]. ⁶¹	Nitrini R...Spina-Franca A	3322242	1987
26	Ischemic cerebrovascular disease in the young. Two common causes in India. ⁶¹	Srinivasan K	6464068	1984
27	Symptomatic neurosyphilis. ⁶¹	Lee JB...Choi IS	6662603	1983
28	[Myelin basic protein in cerebrospinal fluid in neurosyphilis (author's transl)]. ⁶¹	Prange H...Ritter G	6159144	1980
29	[Meningovascular neurosyphilis. Report of a case with radiographically verified cerebral angiopathy]. ⁶¹	Mondrup K...Thogersen G	595192	1977
30	Poikiloderma atrophicans vasculare Jacobi; cutaneous changes typical of this disease in a patient with late meningovascular neurosyphilis. ⁶¹	KALZ F...HOOGSTRATEN J	21026343	1946

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Genes for Meningovascular Neurosyphilis

Genes related to Meningovascular Neurosyphilis (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CXCL13	C-X-C Motif Chemokine Ligand 13	Protein Coding	4.95	DISEASES inferred ¹⁵
2	MBP	Myelin Basic Protein	Protein Coding	4.69	DISEASES inferred ¹⁵
3	CD40LG	CD40 Ligand	Protein Coding	4.54	DISEASES inferred ¹⁵
4	TCHH	Trichohyalin	Protein Coding	4.34	DISEASES inferred ¹⁵
5	ALB	Albumin	Protein Coding	4.05	DISEASES inferred ¹⁵
6	IL17RA	Interleukin 17 Receptor A	Protein Coding	3.91	DISEASES inferred ¹⁵
7	MYH9	Myosin Heavy Chain 9	Protein Coding	3.88	DISEASES inferred ¹⁵
8	IL17A	Interleukin 17A	Protein Coding	3.86	DISEASES inferred ¹⁵
9	CD59	CD59 Molecule (CD59 Blood Group)	Protein Coding	3.66	DISEASES inferred ¹⁵
10	CD4	CD4 Molecule	Protein Coding	3.59	DISEASES inferred ¹⁵
11	HAMP	Hepcidin Antimicrobial Peptide	Protein Coding	3.45	DISEASES inferred ¹⁵
12	CRP	C-Reactive Protein	Protein Coding	3.37	DISEASES inferred ¹⁵

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Variations for Meningovascular Neurosyphilis

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Expression for Meningovascular Neurosyphilis

Search GEO for disease gene expression data for Meningovascular Neurosyphilis.

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Pathways for Meningovascular Neurosyphilis

Pathways related to Meningovascular Neurosyphilis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	12.17	MYH9 IL17RA IL17A CXCL13 CD40LG CD4
2	Th17 Differentiation ⁶⁴ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴	11.09	IL17RA IL17A CD4

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GO Terms for Meningovascular Neurosyphilis

Cellular components related to Meningovascular Neurosyphilis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.5	IL17A HAMP CXCL13 CRP CD59 CD40LG
2	extracellular region	GO:0005576	9.23	IL17RA IL17A HAMP CXCL13 CRP CD59

Biological processes related to Meningovascular Neurosyphilis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	inflammatory response	GO:0006954	9.71	IL17A CXCL13 CRP CD40LG
2	cell surface receptor signaling pathway	GO:0007166	9.67	IL17RA CXCL13 CD59 CD4
3	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.43	IL17RA IL17A
4	interleukin-17-mediated signaling pathway	GO:0097400	9.32	IL17RA IL17A
5	positive regulation of interleukin-23 production	GO:0032747	9.26	IL17RA IL17A
6	fibroblast activation	GO:0072537	9.16	IL17RA IL17A
7	defense response to fungus	GO:0050832	9.13	IL17RA IL17A HAMP
8	immune response	GO:0006955	9.1	MBP IL17A HAMP CXCL13 CD40LG CD4

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