Meningovascular Neurosyphilis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MNN005 MIFTS: 26	Meningovascular Neurosyphilis Categories: Infectious diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Meningovascular Neurosyphilis

MalaCards integrated aliases for Meningovascular Neurosyphilis:

Name: Meningovascular Neurosyphilis ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050491

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Summaries for Meningovascular Neurosyphilis

Disease Ontology : ¹² A tertiary neurosyphilis that results in inflammation located in arteries of the brain or located in arteries of spinal cord. The infection has symptom headache, has symptom neck stiffness, has symptom dizziness, has symptom behavioral abnormalities, has symptom poor concentration, has symptom memory loss, has symptom lassitude, has symptom insomnia, has symptom blurred vision, has symptom weakness and wasting of shoulder-girdle and arm muscles, has symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has symptom paralysis of the legs due to thrombosis of spinal arteries.

MalaCards based summary : Meningovascular Neurosyphilis is related to neurosyphilis and asymptomatic neurosyphilis. An important gene associated with Meningovascular Neurosyphilis is CXCL13 (C-X-C Motif Chemokine Ligand 13), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. Affiliated tissues include brain and spinal cord, and related phenotypes are cellular and hematopoietic system

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Related Diseases for Meningovascular Neurosyphilis

Diseases related to Meningovascular Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 291)

#	Related Disease	Score	Top Affiliating Genes
1	neurosyphilis	33.4	IL17A CXCL13
2	asymptomatic neurosyphilis	30.8	MYH9 CXCL13 CD40LG CD4
3	aspiration pneumonia	30.0	IL17A CD40LG ALB
4	meningitis	29.7	IL17A CXCL13 CD40LG ALB
5	acquired immunodeficiency syndrome	29.7	MBP CD40LG CD4 ALB
6	syphilis	29.0	MYH9 IL17A DDX41 CD40LG CD4 ALB
7	late congenital syphilis	10.4	DDX41 CD40LG
8	cardiovascular syphilis	10.4	TCHH DDX41
9	dysgammaglobulinemia	10.4	MBP CD40LG
10	thrombosis	10.3
11	hemiplegia	10.3
12	cerebrovascular disease	10.3
13	yaws	10.3	MYH9 CD40LG
14	early congenital syphilis	10.3	MYH9 CD40LG
15	early yaws	10.3	CD40LG CD4
16	ocular toxoplasmosis	10.3	IL17A CD40LG
17	gastroduodenitis	10.3	CD40LG CD4
18	neuroretinitis	10.3	CD40LG CD4
19	optic papillitis	10.3	CD40LG CD4
20	transverse myelitis	10.3	MBP IL17A
21	viral exanthem	10.3	CD40LG CD4
22	acute retinal necrosis syndrome	10.2	CD40LG CD4
23	schuurs-hoeijmakers syndrome	10.2	DDX41 CD40LG
24	cerebral lymphoma	10.2	CD40LG CD4
25	west nile encephalitis	10.2	CD40LG CD4
26	mononeuritis of upper limb and mononeuritis multiplex	10.2	CD40LG CD4
27	aortitis	10.2	IL17A CD40LG
28	mononeuritis multiplex	10.2	CD40LG CD4
29	cerebritis	10.2	CD40LG CD4
30	chancroid	10.2	CD40LG CD4
31	cat-scratch disease	10.2	CD40LG CD4
32	parotid disease	10.2	CD40LG CD4
33	exanthema subitum	10.2	CD40LG CD4
34	trichinosis	10.2	CD40LG CD4
35	granulomatous dermatitis	10.2	CD40LG CD4
36	splenic sequestration	10.2	CD40LG CD4
37	bartonellosis	10.2	CD40LG CD4
38	pityriasis rosea	10.2	CD40LG CD4
39	adenoid hypertrophy	10.2	CD40LG CD4
40	sporotrichosis	10.2	CD40LG CD4
41	uveoparotid fever	10.2	CD40LG CD4
42	chronic meningitis	10.2	CD40LG CD4
43	good syndrome	10.2	CD40LG CD4
44	chlamydia pneumonia	10.2	CD40LG CD4
45	mite infestation	10.2	CD40LG CD4
46	monkeypox	10.2	CD40LG CD4
47	polyclonal hypergammaglobulinemia	10.2	CD40LG CD4
48	iritis	10.2	CD40LG CD4
49	hairy tongue	10.2	CD40LG CD4
50	xerophthalmia	10.2	CD40LG CD4

Graphical network of the top 20 diseases related to Meningovascular Neurosyphilis:

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Symptoms & Phenotypes for Meningovascular Neurosyphilis

MGI Mouse Phenotypes related to Meningovascular Neurosyphilis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	9.76	ALB CD4 CD40LG CD59 CXCL13 IL17RA
2	hematopoietic system	MP:0005397	9.56	CD4 CD40LG CD59 CXCL13 IL17A IL17RA
3	immune system	MP:0005387	9.23	ALB CD4 CD40LG CXCL13 IL17A IL17RA

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Drugs & Therapeutics for Meningovascular Neurosyphilis

Search Clinical Trials , NIH Clinical Center for Meningovascular Neurosyphilis

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Genetic Tests for Meningovascular Neurosyphilis

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Anatomical Context for Meningovascular Neurosyphilis

MalaCards organs/tissues related to Meningovascular Neurosyphilis:

⁴⁰

Brain, Spinal Cord

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Publications for Meningovascular Neurosyphilis

Articles related to Meningovascular Neurosyphilis:

(show all 30)

#	Title	Authors	PMID	Year
1	Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series. ⁶¹	Borges CR...Teive HAG	29972419	2018
2	Meningovascular neurosyphilis with basilar artery thrombosis in HIV patient. ⁶¹	Perez Barragan E...Sanchez Gonzalez M	28993174	2018
3	Neurosyphilis Masquerading as Stroke in an 84-year-old. ⁶¹	Bologa C...Luca C	29967874	2017
4	Prevalence of positive syphilis serology and meningovascular neurosyphilis in patients admitted with stroke and TIA from a culturally diverse population (2005-09). ⁶¹	Cordato DJ...McDougall AJ	23669171	2013
5	Spectrum and characterization of movement disorders secondary to neurosyphilis. ⁶¹	Tong ML...Yang TC	23395216	2013
6	Ischemic stroke as a primary symptom of neurosyphilis among HIV-negative emergency patients. ⁶¹	Liu LL...Yang TC	22482824	2012
7	[Meningovascular neurosyphilis with basilar artery thrombosis, a case report and literature review]. ⁶¹	Jimenez JA...Ochoa JA	23235782	2012
8	[Meningovascular neurosyphilis as the cause of ischemic cerebrovascular disease in a young man]. ⁶¹	Toth V...Karpati S	21498167	2011
9	Amnestic syndrome due to meningovascular neurosyphilis. ⁶¹	Kearney H...O'Rourke K	19997924	2010
10	Meningovascular neurosyphilis: a report of stroke in a young adult. ⁶¹	Vaitkus A...Urbonaviciute I	20571297	2010
11	[Concentration of benzylpenicillin sodium salt in the cerebrospinal fluid of patients with late neurosyphilis as an indicator of efficacy of specific therapy]. ⁶¹	Rodikov MV...Rudnev VA	19491815	2009
12	[Meningovascular neurosyphilis]. ⁶¹	Adeva Bartolome MT...Hernandez Bayo JM	17688870	2007
13	[Autopsy case of meningovascular neurosyphilis associated with Fischer's plaques]. ⁶¹	Obi K...Akiyama H	17663152	2007
14	Intrathecal IgA synthesis in neurosyphilis. ⁶¹	Ebinger M...Uhr M	15607206	2005
15	[Neurosyphilis presenting the left total ophthalmoplegia: a case report]. ⁶¹	Takakura Y...Miyoshi T	15287513	2004
16	[Diagnosis and biological monitoring of 6 neurosyphilis cases: value of cerebrospinal fluid analysis]. ⁶¹	Caudie C...Vandenberghe N	14671754	2003
17	[Neurosyphilis: forms of presentation and clinical management]. ⁶¹	Conde-Sendin MA...Amela-Peris R	12235572	2002
18	Dementia following an acute presentation of meningovascular neurosyphilis in an HIV-1 positive patient. ⁶¹	Fox PA...Dawson S	10997420	2000
19	[Neurosyphilis 12 years after treatment of primary infection in a meanwhile HIV infected patient]. ⁶¹	Eriksson U...Frick H	9289822	1997
20	Magnetic resonance angiography in meningovascular syphilis. ⁶¹	Gallego J...Villanueva JA	8041441	1994
21	Reactivity of locally produced CSF antibodies in patients with neurosyphilis against antigens of Treponema pallidum. ⁶¹	Bollensen E...Prange HW	8263552	1993
22	[Bilateral internal carotid artery stenoses in a patient with meningovascular neurosyphilis]. ⁶¹	Ohya Y...Shiozawa R	8261700	1993
23	Meningovascular neurosyphilis in human immunodeficiency virus infection as a differential diagnosis of focal CNS lesions: a clinicopathological study. ⁶¹	Peters M...Ruf B	8370947	1993
24	Pure motor hemiplegia due to meningovascular neurosyphilis. ⁶¹	Johns DR...Parker SW	3632380	1987
25	[Intravenous penicillin therapy in high doses in neurosyphilis: study of 62 cases. I. Clinical evaluation]. ⁶¹	Nitrini R...Spina-Franca A	3322242	1987
26	Ischemic cerebrovascular disease in the young. Two common causes in India. ⁶¹	Srinivasan K	6464068	1984
27	Symptomatic neurosyphilis. ⁶¹	Lee JB...Choi IS	6662603	1983
28	[Myelin basic protein in cerebrospinal fluid in neurosyphilis (author's transl)]. ⁶¹	Prange H...Ritter G	6159144	1980
29	[Meningovascular neurosyphilis. Report of a case with radiographically verified cerebral angiopathy]. ⁶¹	Mondrup K...Thogersen G	595192	1977
30	Poikiloderma atrophicans vasculare Jacobi; cutaneous changes typical of this disease in a patient with late meningovascular neurosyphilis. ⁶¹	KALZ F...HOOGSTRATEN J	21026343	1946

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Genes for Meningovascular Neurosyphilis

Genes related to Meningovascular Neurosyphilis (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CXCL13	C-X-C Motif Chemokine Ligand 13	Protein Coding	5.03	DISEASES inferred ¹⁵
2	MBP	Myelin Basic Protein	Protein Coding	4.72	DISEASES inferred ¹⁵
3	CD40LG	CD40 Ligand	Protein Coding	4.58	DISEASES inferred ¹⁵
4	TCHH	Trichohyalin	Protein Coding	4.42	DISEASES inferred ¹⁵
5	DDX41	DEAD-Box Helicase 41	Protein Coding	4	DISEASES inferred ¹⁵
6	IL17RA	Interleukin 17 Receptor A	Protein Coding	3.98	DISEASES inferred ¹⁵
7	MYH9	Myosin Heavy Chain 9	Protein Coding	3.94	DISEASES inferred ¹⁵
8	IL17A	Interleukin 17A	Protein Coding	3.93	DISEASES inferred ¹⁵
9	ALB	Albumin	Protein Coding	3.88	DISEASES inferred ¹⁵
10	CD59	CD59 Molecule (CD59 Blood Group)	Protein Coding	3.76	DISEASES inferred ¹⁵
11	CD4	CD4 Molecule	Protein Coding	3.3	DISEASES inferred ¹⁵

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Variations for Meningovascular Neurosyphilis

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Expression for Meningovascular Neurosyphilis

Search GEO for disease gene expression data for Meningovascular Neurosyphilis.

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Pathways for Meningovascular Neurosyphilis

Pathways related to Meningovascular Neurosyphilis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	12.17	MYH9 IL17RA IL17A CXCL13 CD40LG CD4
2	Allograft rejection ³⁶ ¹ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12	IL17A CXCL13 CD40LG CD4

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GO Terms for Meningovascular Neurosyphilis

Biological processes related to Meningovascular Neurosyphilis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface receptor signaling pathway	GO:0007166	9.56	IL17RA CXCL13 CD59 CD4
2	defense response to fungus	GO:0050832	9.4	IL17RA IL17A
3	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.37	IL17RA IL17A
4	immune response	GO:0006955	9.35	MBP IL17A CXCL13 CD40LG CD4
5	interleukin-17-mediated signaling pathway	GO:0097400	9.32	IL17RA IL17A
6	positive regulation of interleukin-23 production	GO:0032747	9.16	IL17RA IL17A
7	fibroblast activation	GO:0072537	8.62	IL17RA IL17A

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Sources for Meningovascular Neurosyphilis

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