MCID: MNN005
MIFTS: 26

Meningovascular Neurosyphilis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Meningovascular Neurosyphilis

MalaCards integrated aliases for Meningovascular Neurosyphilis:

Name: Meningovascular Neurosyphilis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050491

Summaries for Meningovascular Neurosyphilis

Disease Ontology : 12 A tertiary neurosyphilis that results in inflammation located in arteries of the brain or located in arteries of spinal cord. The infection has symptom headache, has symptom neck stiffness, has symptom dizziness, has symptom behavioral abnormalities, has symptom poor concentration, has symptom memory loss, has symptom lassitude, has symptom insomnia, has symptom blurred vision, has symptom weakness and wasting of shoulder-girdle and arm muscles, has symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has symptom paralysis of the legs due to thrombosis of spinal arteries.

MalaCards based summary : Meningovascular Neurosyphilis is related to neurosyphilis and asymptomatic neurosyphilis. An important gene associated with Meningovascular Neurosyphilis is CXCL13 (C-X-C Motif Chemokine Ligand 13), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. Affiliated tissues include brain and spinal cord, and related phenotypes are cellular and hematopoietic system

Related Diseases for Meningovascular Neurosyphilis

Diseases related to Meningovascular Neurosyphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 291)
# Related Disease Score Top Affiliating Genes
1 neurosyphilis 33.4 IL17A CXCL13
2 asymptomatic neurosyphilis 30.8 MYH9 CXCL13 CD40LG CD4
3 aspiration pneumonia 30.0 IL17A CD40LG ALB
4 meningitis 29.7 IL17A CXCL13 CD40LG ALB
5 acquired immunodeficiency syndrome 29.7 MBP CD40LG CD4 ALB
6 syphilis 29.0 MYH9 IL17A DDX41 CD40LG CD4 ALB
7 late congenital syphilis 10.4 DDX41 CD40LG
8 cardiovascular syphilis 10.4 TCHH DDX41
9 dysgammaglobulinemia 10.4 MBP CD40LG
10 thrombosis 10.3
11 hemiplegia 10.3
12 cerebrovascular disease 10.3
13 yaws 10.3 MYH9 CD40LG
14 early congenital syphilis 10.3 MYH9 CD40LG
15 early yaws 10.3 CD40LG CD4
16 ocular toxoplasmosis 10.3 IL17A CD40LG
17 gastroduodenitis 10.3 CD40LG CD4
18 neuroretinitis 10.3 CD40LG CD4
19 optic papillitis 10.3 CD40LG CD4
20 transverse myelitis 10.3 MBP IL17A
21 viral exanthem 10.3 CD40LG CD4
22 acute retinal necrosis syndrome 10.2 CD40LG CD4
23 schuurs-hoeijmakers syndrome 10.2 DDX41 CD40LG
24 cerebral lymphoma 10.2 CD40LG CD4
25 west nile encephalitis 10.2 CD40LG CD4
26 mononeuritis of upper limb and mononeuritis multiplex 10.2 CD40LG CD4
27 aortitis 10.2 IL17A CD40LG
28 mononeuritis multiplex 10.2 CD40LG CD4
29 cerebritis 10.2 CD40LG CD4
30 chancroid 10.2 CD40LG CD4
31 cat-scratch disease 10.2 CD40LG CD4
32 parotid disease 10.2 CD40LG CD4
33 exanthema subitum 10.2 CD40LG CD4
34 trichinosis 10.2 CD40LG CD4
35 granulomatous dermatitis 10.2 CD40LG CD4
36 splenic sequestration 10.2 CD40LG CD4
37 bartonellosis 10.2 CD40LG CD4
38 pityriasis rosea 10.2 CD40LG CD4
39 adenoid hypertrophy 10.2 CD40LG CD4
40 sporotrichosis 10.2 CD40LG CD4
41 uveoparotid fever 10.2 CD40LG CD4
42 chronic meningitis 10.2 CD40LG CD4
43 good syndrome 10.2 CD40LG CD4
44 chlamydia pneumonia 10.2 CD40LG CD4
45 mite infestation 10.2 CD40LG CD4
46 monkeypox 10.2 CD40LG CD4
47 polyclonal hypergammaglobulinemia 10.2 CD40LG CD4
48 iritis 10.2 CD40LG CD4
49 hairy tongue 10.2 CD40LG CD4
50 xerophthalmia 10.2 CD40LG CD4

Graphical network of the top 20 diseases related to Meningovascular Neurosyphilis:



Diseases related to Meningovascular Neurosyphilis

Symptoms & Phenotypes for Meningovascular Neurosyphilis

MGI Mouse Phenotypes related to Meningovascular Neurosyphilis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.76 ALB CD4 CD40LG CD59 CXCL13 IL17RA
2 hematopoietic system MP:0005397 9.56 CD4 CD40LG CD59 CXCL13 IL17A IL17RA
3 immune system MP:0005387 9.23 ALB CD4 CD40LG CXCL13 IL17A IL17RA

Drugs & Therapeutics for Meningovascular Neurosyphilis

Search Clinical Trials , NIH Clinical Center for Meningovascular Neurosyphilis

Genetic Tests for Meningovascular Neurosyphilis

Anatomical Context for Meningovascular Neurosyphilis

MalaCards organs/tissues related to Meningovascular Neurosyphilis:

40
Brain, Spinal Cord

Publications for Meningovascular Neurosyphilis

Articles related to Meningovascular Neurosyphilis:

(show all 30)
# Title Authors PMID Year
1
Neurosyphilis and ocular syphilis clinical and cerebrospinal fluid characteristics: a case series. 61
29972419 2018
2
Meningovascular neurosyphilis with basilar artery thrombosis in HIV patient. 61
28993174 2018
3
Neurosyphilis Masquerading as Stroke in an 84-year-old. 61
29967874 2017
4
Prevalence of positive syphilis serology and meningovascular neurosyphilis in patients admitted with stroke and TIA from a culturally diverse population (2005-09). 61
23669171 2013
5
Spectrum and characterization of movement disorders secondary to neurosyphilis. 61
23395216 2013
6
Ischemic stroke as a primary symptom of neurosyphilis among HIV-negative emergency patients. 61
22482824 2012
7
[Meningovascular neurosyphilis with basilar artery thrombosis, a case report and literature review]. 61
23235782 2012
8
[Meningovascular neurosyphilis as the cause of ischemic cerebrovascular disease in a young man]. 61
21498167 2011
9
Amnestic syndrome due to meningovascular neurosyphilis. 61
19997924 2010
10
Meningovascular neurosyphilis: a report of stroke in a young adult. 61
20571297 2010
11
[Concentration of benzylpenicillin sodium salt in the cerebrospinal fluid of patients with late neurosyphilis as an indicator of efficacy of specific therapy]. 61
19491815 2009
12
[Meningovascular neurosyphilis]. 61
17688870 2007
13
[Autopsy case of meningovascular neurosyphilis associated with Fischer's plaques]. 61
17663152 2007
14
Intrathecal IgA synthesis in neurosyphilis. 61
15607206 2005
15
[Neurosyphilis presenting the left total ophthalmoplegia: a case report]. 61
15287513 2004
16
[Diagnosis and biological monitoring of 6 neurosyphilis cases: value of cerebrospinal fluid analysis]. 61
14671754 2003
17
[Neurosyphilis: forms of presentation and clinical management]. 61
12235572 2002
18
Dementia following an acute presentation of meningovascular neurosyphilis in an HIV-1 positive patient. 61
10997420 2000
19
[Neurosyphilis 12 years after treatment of primary infection in a meanwhile HIV infected patient]. 61
9289822 1997
20
Magnetic resonance angiography in meningovascular syphilis. 61
8041441 1994
21
Reactivity of locally produced CSF antibodies in patients with neurosyphilis against antigens of Treponema pallidum. 61
8263552 1993
22
[Bilateral internal carotid artery stenoses in a patient with meningovascular neurosyphilis]. 61
8261700 1993
23
Meningovascular neurosyphilis in human immunodeficiency virus infection as a differential diagnosis of focal CNS lesions: a clinicopathological study. 61
8370947 1993
24
Pure motor hemiplegia due to meningovascular neurosyphilis. 61
3632380 1987
25
[Intravenous penicillin therapy in high doses in neurosyphilis: study of 62 cases. I. Clinical evaluation]. 61
3322242 1987
26
Ischemic cerebrovascular disease in the young. Two common causes in India. 61
6464068 1984
27
Symptomatic neurosyphilis. 61
6662603 1983
28
[Myelin basic protein in cerebrospinal fluid in neurosyphilis (author's transl)]. 61
6159144 1980
29
[Meningovascular neurosyphilis. Report of a case with radiographically verified cerebral angiopathy]. 61
595192 1977
30
Poikiloderma atrophicans vasculare Jacobi; cutaneous changes typical of this disease in a patient with late meningovascular neurosyphilis. 61
21026343 1946

Variations for Meningovascular Neurosyphilis

Expression for Meningovascular Neurosyphilis

Search GEO for disease gene expression data for Meningovascular Neurosyphilis.

Pathways for Meningovascular Neurosyphilis

Pathways related to Meningovascular Neurosyphilis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.17 MYH9 IL17RA IL17A CXCL13 CD40LG CD4
2
Show member pathways
12 IL17A CXCL13 CD40LG CD4

GO Terms for Meningovascular Neurosyphilis

Biological processes related to Meningovascular Neurosyphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.56 IL17RA CXCL13 CD59 CD4
2 defense response to fungus GO:0050832 9.4 IL17RA IL17A
3 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.37 IL17RA IL17A
4 immune response GO:0006955 9.35 MBP IL17A CXCL13 CD40LG CD4
5 interleukin-17-mediated signaling pathway GO:0097400 9.32 IL17RA IL17A
6 positive regulation of interleukin-23 production GO:0032747 9.16 IL17RA IL17A
7 fibroblast activation GO:0072537 8.62 IL17RA IL17A

Sources for Meningovascular Neurosyphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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