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MCID: MNT002
MIFTS: 57

Mental Depression

Categories: Mental diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Mental Depression

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MalaCards integrated aliases for Mental Depression:

Name: Mental Depression 12 15 73
Depressive Disorder 73
Depression 44

Classifications:

MalaCards categories:
Anatomical: Mental diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1596
ICD10 33 F32.9 F33.9
MeSH 44 D003863
NCIt 50 C2982
Sources

Summaries for Mental Depression

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MalaCards based summary : Mental Depression, also known as depressive disorder, is related to depression and endogenous depression, and has symptoms including affective symptoms, behavioral symptoms and schizophrenic language. An important gene associated with Mental Depression is IER3IP1 (Immediate Early Response 3 Interacting Protein 1), and among its related pathways/superpathways are Neuroscience and Circadian rythm related genes. The drugs Citalopram and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and testes, and related phenotypes are behavior/neurological and homeostasis/metabolism

Sources

Related Diseases for Mental Depression

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Diseases related to Mental Depression via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 depression 31.3 BDNF CRH HTR1A HTR2A HTR2C MAOA
2 endogenous depression 29.8 BDNF CRH GATA3 HTR7 IER3IP1 MAOA
3 perry syndrome 11.7
4 alzheimer disease 5 10.9 HTR2A SLC6A4
5 schizoid personality disorder 10.9 HTR1A HTR2A
6 hypoactive sexual desire disorder 10.8 HTR1A HTR2A
7 substance-induced psychosis 10.8 HTR1A HTR2A
8 social phobia 10.8 HTR1A MAOA SLC6A4
9 pathological gambling 10.7 HTR2A MAOA SLC6A4
10 rumination disorder 10.7 HTR1A HTR7
11 intermittent explosive disorder 10.7 HTR1A HTR7 SLC6A4
12 phobia, specific 10.7 COMT MAOA
13 drug-induced mental disorder 10.7 HTR1A HTR2A HTR7
14 drug psychosis 10.7 HTR1A HTR2A HTR7
15 retrograde amnesia 10.6 POMC SLC6A4
16 coronary artery vasospasm 10.6 HTR2A HTR7
17 amnestic disorder 10.6 BDNF HTR1A HTR7
18 alexithymia 10.6 COMT HTR1A SLC6A4
19 melancholia 10.6 CRH IER3IP1
20 hypothalamic disease 10.6 CRH POMC
21 irritable bowel syndrome 10.6 CRH HTR7 SLC6A4
22 antisocial personality disorder 10.6 COMT MAOA SLC6A4
23 pituitary carcinoma 10.6 CRH POMC
24 synucleinopathy 10.6 BDNF COMT IER3IP1
25 conduct disorder 10.5 COMT MAOA SLC6A4
26 childhood disintegrative disease 10.5 BDNF POMC
27 agoraphobia 10.5 HTR1A MAOA SLC6A2 SLC6A4
28 acth deficiency, isolated 10.5 CRH POMC
29 pervasive developmental disorder 10.5 BDNF OXT SLC6A4
30 glucose metabolism disease 10.5 DPP4 IER3IP1 POMC PSMD9
31 periodic limb movement disorder 10.5 HTR1A HTR2A HTR2C SLC6A4
32 acquired metabolic disease 10.5 DPP4 IER3IP1 POMC PSMD9
33 withdrawal disorder 10.5 CRH HTR7 POMC
34 phobic disorder 10.5 COMT HTR1A MAOA SLC6A4
35 avoidant personality disorder 10.4 CRH MAOA WASF1
36 schizoaffective disorder 10.4 BDNF COMT HTR2A SLC6A4
37 substance abuse 10.4 BDNF COMT MAOA SLC6A4
38 tardive dyskinesia 10.4 COMT HTR2A
39 fibromyalgia 10.4 COMT CRH HTR2A SLC6A4
40 substance dependence 10.4 BDNF MAOA POMC SLC6A4
41 drug dependence 10.4 BDNF CRH POMC SLC6A4
42 premature ejaculation 10.4 COMT HTR1A HTR2C SLC6A4
43 kleine-levin hibernation syndrome 10.3 COMT HTR7 POMC
44 premenstrual tension 10.3 CRH OXT POMC
45 autism spectrum disorder 10.3 BDNF HTR2A OXT SLC6A4
46 nelson syndrome 10.3 CRH POMC
47 kleptomania 10.3 GATA3 HTR1A HTR7 MAOA SLC6A4
48 dysthymic disorder 10.3 GATA3 HTR2A HTR7 MAOA SLC6A4
49 atypical depressive disorder 10.3 CRH GATA3 HTR7 MAOA SLC6A4
50 early-onset schizophrenia 10.2 BDNF COMT HTR2A MAOA SLC6A4

Graphical network of the top 20 diseases related to Mental Depression:



Diseases related to Mental Depression
Sources

Symptoms & Phenotypes for Mental Depression

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UMLS symptoms related to Mental Depression:


affective symptoms, behavioral symptoms, schizophrenic language, depressive symptoms, dejection emotional, depressed reaction, depression aggravated, depressed - symptom

MGI Mouse Phenotypes related to Mental Depression:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.34 MAOA SLC6A4 OXT TPH2 POMC WASF1
2 homeostasis/metabolism MP:0005376 10.16 MAOA SLC6A4 OXT TPH2 POMC SLC6A2
3 cardiovascular system MP:0005385 10.06 SLC6A2 MAOA SLC6A4 OXT TPH2 POMC
4 growth/size/body region MP:0005378 10.06 SLC6A2 SLC6A4 OXT TPH2 WASF1 POMC
5 endocrine/exocrine gland MP:0005379 10.02 SLC6A4 OXT POMC HTR2A CRH DPP4
6 adipose tissue MP:0005375 9.93 OXT TPH2 POMC CRH HTR2C GATA3
7 integument MP:0010771 9.85 SLC6A4 OXT TPH2 POMC SLC6A2 CRH
8 mortality/aging MP:0010768 9.77 SLC6A4 OXT TPH2 POMC WASF1 SLC6A2
9 nervous system MP:0003631 9.5 MAOA SLC6A4 OXT TPH2 POMC WASF1
Sources

Drugs & Therapeutics for Mental Depression

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Drugs for Mental Depression (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1154)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59729-33-8 2771
2
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 51-61-6, 62-31-7 681
3
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-41-2 439260
4
Cycloserine Approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 68-41-7 401 6234
5
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 6740-88-1 3821
6
Clonazepam Approved, Illicit Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 1622-61-3 2802
7
Sertraline Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 79617-96-2 68617
8
Bupropion Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 34841-39-9, 34911-55-2 444
9
Ropinirole Approved, Investigational Phase 4,Phase 3,Not Applicable 91374-20-8, 91374-21-9 5095 497540
10
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-23-7 5754
11
Copper Approved, Investigational Phase 4,Phase 3 7440-50-8 27099
12
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-28-2 5757
13 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 979-32-8
14
Ethinyl Estradiol Approved Phase 4,Phase 2,Not Applicable 57-63-6 5991
15
Norethindrone Approved Phase 4,Not Applicable 68-22-4 6230
16
Polyestradiol phosphate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 28014-46-2
17
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-84-3 187
18
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 75614-87-8, 51-45-6 774
19
Mianserin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 24219-97-4 4184
20
Mirtazapine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 85650-52-8, 61337-67-5 4205
21
Amitriptyline Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-48-6 2160
22
Nortriptyline Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 72-69-5 4543
23
Paroxetine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 61869-08-7 43815
24
Perphenazine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 58-39-9 4748
25
Trimipramine Approved Phase 4,Phase 3 739-71-9 5584 4055
26
Buspirone Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 36505-84-7 2477
27
Reboxetine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 98769-81-4, 71620-89-8 123628 65856
28
Eszopiclone Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 138729-47-2 969472
29
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 64-17-5 702
30
Fluoxetine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 54910-89-3 3386
31
Lactulose Approved Phase 4 4618-18-2 11333
32
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 27203-92-5 33741
33
Diphenhydramine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 147-24-0, 58-73-1 3100
34
Promethazine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 60-87-7 4927
35
Suvorexant Approved, Investigational Phase 4 1030377-33-3
36
Fluvoxamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 54739-18-3 3404 5324346
37
Aripiprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 129722-12-9 60795
38
Methyltestosterone Approved Phase 4,Phase 3,Phase 2,Not Applicable 58-18-4 6010
39
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 58-22-0 6013
40
Testosterone enanthate Approved Phase 4,Phase 3,Phase 2,Not Applicable 315-37-7 9416
41
Testosterone undecanoate Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 5949-44-0
42
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2078-54-8 4943
43
Succinylcholine Approved Phase 4,Not Applicable 306-40-1 5314
44
Acetylcysteine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 616-91-1 12035
45
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 28523-86-6 5206
46
Trazodone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 19794-93-5 5533
47
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
48
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
49
Lamotrigine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 84057-84-1 3878
50
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 113775-47-6 68602 5311068

Interventional clinical trials:

(show top 50) (show all 10000)
# Name Status NCT ID Phase Drugs
1 The Preventive Effect of Escitalopram on Depression and Related Emotional Disorders in Acute Stroke Patients Unknown status NCT01278498 Phase 4 Escitalopram;sugar pill
2 Inflammatory Markers and Cognitive Function in Major Depression Unknown status NCT01391221 Phase 4 Duloxetine
3 Neurophysiologic Changes in Patients With Bipolar Depression Unknown status NCT01213121 Phase 4 Quetiapine
4 A Comprehensive Intervention for Diabetes and Comorbid Depression in Primary Care Unknown status NCT00939250 Phase 4
5 A Comparative Trial of TMS Approaches to Treating Depression Unknown status NCT01906905 Phase 4
6 Cymbalta for Depression as a Complication of Bereavement Unknown status NCT00658931 Phase 4 Drug treatment with Cymbalta
7 D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression Unknown status NCT02772211 Phase 4 Ketamine;D-cycloserine;Placebo
8 Can Vitamin D3 Supplementation Affect Treatment Outcomes in Patients With Depression Unknown status NCT01390662 Phase 4
9 Efficacy and Safety Study of Desvenlafaxine in the Treatment of Vascular Depression Unknown status NCT01974934 Phase 4 Desvenlafaxine Succinate
10 Neurochemical, Metabonomics and Neuroimaging Characterization of TCM Diagnostic Subtypes of Major Depression Disorder Unknown status NCT02346682 Phase 4 venlafaxine
11 DECARD: Study of Escitalopram in the Prevention of Depression in Patients With Acute Coronary Syndrome Unknown status NCT00140257 Phase 4 Escitalopram
12 Sequence Towards Remission in Depression Unknown status NCT01628783 Phase 4 escitalopram 10 mg;Placebo
13 Lithium and Standard Therapy in Resistant Depression Unknown status NCT00927550 Phase 4 lithium;usual care
14 Efficacy Study of Escitalopram for Depression in Patients With Diabetes Unknown status NCT00650897 Phase 4 Escitalopram
15 Preliminary Study to Investigate the Effect of rTMS and SSRI Antidepressants on Leukocyte Expression of the C-FOS and DUSP1 Genes in Patients Treated for Depression Unknown status NCT02042573 Phase 4 SSRI (SEROPLEX ou ZOLOFT)
16 Depression Care Management for Depressed Elders in China Primary Care Unknown status NCT01287494 Phase 4 Sertraline
17 Effect of Partial Sleep Deprivation on Cognition and Cytokines in Individuals With Major Depression Unknown status NCT00291239 Phase 4
18 Integral Assessment in Unipolar Depression Unknown status NCT02268487 Phase 4 Sertraline
19 Antidepressant Maintenance in Traumatic Brain Injury Unknown status NCT00162916 Phase 4 citalopram;Placebo
20 A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar Depression. Unknown status NCT00335205 Phase 4 ropinirole
21 Medications for the Treatment of Dysthymic Disorder and Double Depression Unknown status NCT00234312 Phase 4 escitalopram and sertraline
22 Duloxetine for Major Depression in Peri-/Postmenopausal Women Unknown status NCT00889369 Phase 4 Duloxetine
23 Hormone and Sleep Response to Antidepressant Treatment in Adolescents and Adults With Depression Unknown status NCT00106197 Phase 4 Bupropion
24 Effectiveness of Repetitive Transcranial Magnetic Stimulation in Depressed Patients Unknown status NCT02213016 Phase 4
25 Oral Contraceptive Ethinyl Estradiol Dose Effect on Postpartum Depression and Sexual Functioning Scales Unknown status NCT02210702 Phase 4 Ethinyl Estradiol 35mcg/Norethindrone 1mg;Ethinyl Estradiol 20mcg/Norethindrone 1mg
26 Estrogen and Perimenopausal Depression Unknown status NCT00229450 Phase 4 estrogen
27 Efficacy Study of Botox for Depression Unknown status NCT01556971 Phase 4 Botox;Saline Solution
28 Using Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Bipolar Depression Unknown status NCT01583023 Phase 4 Bupropion
29 Effect of Antidepressants on White Matter Structure Unknown status NCT01492621 Phase 4 Desvenlafaxine
30 International Study to Predict Optimised Treatment - in Depression Unknown status NCT00693849 Phase 4 Escitalopram;Sertraline;Venlafaxine-XR
31 Efficacy of MBI for Depressive Symptoms in Patients With MS Unknown status NCT02611401 Phase 4
32 Hippocampal Volume in Young Patients With Major Depression Before and After Combined Antidepressive Therapy Unknown status NCT00150839 Phase 4 Mirtazapine;Venlafaxine
33 Optimizing Antidepressant Treatment by Genotype-dependent Adjustment of Medication According to the ABCB1 Gene Unknown status NCT02237937 Phase 4 Paroxetine;Sertraline;Citalopram;Venlafaxine;Amitriptyline;Escitalopram;Amitriptylinoxide;Nortriptyline;Trimipramine
34 Treatment of Mild and Subthreshold Depressive Disorders Unknown status NCT00226642 Phase 4 Sertralin;Placebo
35 Randomized，Controlled and Open-label Study of Buspirone add-on Treatment in Patients With Major Depression Disorder Unknown status NCT02273154 Phase 4 Buspirone;Paroxetine
36 Benefits of Switching Antidepressants Following Early Nonresponse Unknown status NCT00519012 Phase 4 Sertraline to Paroxetine;Paroxetine to Sertraline
37 Reboxetine Treatment in Depressed Children and Adolescents an 8-Week, Open Study Unknown status NCT00426946 Phase 4 Reboxetine
38 Brain Mechanisms and Targeting Insomnia in Major Depression Unknown status NCT00628914 Phase 4 escitalopram and eszopiclone;Escitalopram, eszopiclone, and placebo;Escitalopram
39 Clinical Pharmacogenomics of Antidepressant Response Unknown status NCT00269334 Phase 4 Using Citalopram(drug) or Paroxetine(drug)
40 Prediction of Antidepressant Treatment Response Using Machine Learning Classification Analysis Unknown status NCT02330679 Phase 4 Desvenlafaxine;Placebo
41 Fluoxetine and Bupropion to Treat Patients With Depression and Alcoholism Unknown status NCT00449007 Phase 4 fluoxetine;bupropion
42 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4
43 Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder (MDD) (DEPARRESTCLIN) Unknown status NCT02051413 Phase 4 Venlafaxine extended release
44 Paroxetines Effect on Tramadols Metabolism and Pharmakodynamics: a Dose Response Study Unknown status NCT00785603 Phase 4 Paroxetine;Paroxetin placebo;Tramadol
45 The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope Unknown status NCT01357967 Phase 4 SSRI monotherapy;Seroquel XR adjunctive
46 A Six Week, Randomized, Double-Blind Placebo-Controlled, Suvorexant Augmentation Study of Antidepressant Treatment of Major Depressive Disorder With Residual Insomnia Unknown status NCT02669030 Phase 4 suvorexant;Placebo
47 Cardiopulmonary Capacity in Elderly With Different Ranges of Serum Thyroid Stimulating Hormone Unknown status NCT01849861 Phase 4 Methimazole
48 Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder Unknown status NCT01460212 Phase 4 SSRI antidepressants
49 Aripiprazole (Abilify®) as an Adjunctive Treatment for Inadequate Response in Major Depressive Disorder Unknown status NCT01696617 Phase 4 Aripiprazole 6-week group;Aripiprazole 8-week group
50 Testosterone Therapy on Angina Threshold and Atheroma in Patients With Chronic Stable Angina Unknown status NCT00131183 Phase 4 Nebido

Search NIH Clinical Center for Mental Depression

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: depression

Sources

Genetic Tests for Mental Depression

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Sources

Anatomical Context for Mental Depression

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MalaCards organs/tissues related to Mental Depression:

41
Brain, Heart, Testes, Lung, Prostate, Spinal Cord, Bone
Sources

Publications for Mental Depression

About this section

Articles related to Mental Depression:

(show top 50) (show all 57)
# Title Authors Year
1
Dimorphic anemia and mental depression as a result of systemic manifestations of generalized aggressive periodontitis: A pioneer case report. ( 29491590 )
2017
2
Social support and breast cancer: A comparatory study of breast cancer survivors, women with mental depression, women with hypertension and healthy female controls. ( 28667868 )
2017
3
Correlates of Mental Depression Among Female Sex Workers in Southern India. ( 26307144 )
2015
4
Polyunsaturated fatty acids n-3: new data on heart disease, cancer, immune resistance and mental depression. ( 21384741 )
2010
5
Mental depression and cardiovascular disease: a multifaceted, bidirectional association. ( 19452408 )
2009
6
A controlled study on treatment of mental depression by acupuncture plus TCM medication. ( 17955648 )
2007
7
The brain-resuscitation acupuncture method for treatment of post wind-stroke mental depression--a report of 45 cases. ( 16447661 )
2005
8
Clinical study on electro-acupuncture treatment for 30 cases of mental depression. ( 15510791 )
2004
9
Treatment of mental depression due to liver-qi stagnancy with herbal decoction and by magnetic therapy at the acupoints--a report of 45 cases. ( 15119163 )
2004
10
DPP IV and mental depression in Crohn's disease. ( 12675254 )
2003
11
Neopterin production, tryptophan degradation, and mental depression--what is the link? ( 12401473 )
2002
12
Carbohydrate malabsorption syndromes and early signs of mental depression in females. ( 10961700 )
2000
13
Lactose malabsorption is associated with early signs of mental depression in females: a preliminary report. ( 9824144 )
1998
14
A heuristic model of mental depression derived from basic and applied research on thyrotropin-releasing hormone. ( 9827666 )
1998
15
Fructose malabsorption is associated with early signs of mental depression. ( 9620891 )
1998
16
Mental depression and death in elderly persons. ( 9465545 )
1997
17
Chronobiological approach to the assessment of the role of the striatum in the genesis of mental depression. ( 8801470 )
1996
18
Clinical observation on needling extrachannel points in treating mental depression. ( 8196410 )
1994
19
Electroencephalographic mapping during isoflurane anesthesia for treatment of mental depression. ( 1999695 )
1991
20
Nurses and shiftwork: effects on physical health and mental depression. ( 2394892 )
1990
21
Maprotiline (Ludiomil) treatment of mental depression--a clinical report of 65 cases. ( 2594736 )
1989
22
Mental depression, acute infection and coma in a patient treated with interferon-alpha. ( 2501183 )
1989
23
Measuring the rate of change of voice fundamental frequency in fluent speech during mental depression. ( 3351130 )
1988
24
Mental depression is associated with malnutrition in patients with head and neck cancer. ( 3190874 )
1988
25
Mental depression in untreated Parkinson's disease of recent onset. ( 3825724 )
1987
26
Variations in serum vanadium levels during the treatment of mental depression. ( 3756279 )
1986
27
Seasonal variation in mental depression and its correlation with occupation. ( 3726602 )
1986
28
Mental depression and kundalini yoga. ( 22557558 )
1986
29
Platelet serotonin in essential hypertension and in mental depression. ( 2412030 )
1985
30
Effect of oral contraceptives on tryptophan and tyrosine availability: evidence for a possible contribution to mental depression. ( 7266825 )
1981
31
Mental depression secondary to fluorouracil therapy for actinic keratoses. ( 7425651 )
1980
32
Solvent exposure and mental depression. ( 509886 )
1979
33
Familial fatal Parkinsonism with alveolar hypoventilation and mental depression. ( 43704 )
1979
34
Biochemistry of mental depression. ( 23214 )
1977
35
Pathways to the cure of mental depression. ( 243281 )
1977
36
Sleep disorders in patients with severe mental depression: double-blind placebo-controlled evaluation of the value of pipamperone (Dipiperon). ( 320830 )
1977
37
Antinuclear factor-positive mental depression: a single disease entity? ( 1083254 )
1976
38
Hereditary mental depression and Parkinsonism with taurine deficiency. ( 1122173 )
1975
39
Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. ( 4116150 )
1972
40
Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. ( 4118700 )
1972
41
Parkinsonism, L-dopa and mental depression. ( 5421784 )
1970
42
Studies of mineral metabolism in mental depression. I. The effects of imipramine and electric convulsive therapy on calcium balance and kinetics. ( 5457617 )
1970
43
Chemotherapy of mental depression. ( 4913951 )
1970
44
Vitamin D intoxication, with hypernatraemia, potassium and water depletion, and mental depression. ( 5723727 )
1968
45
Desipramine and nortriptyline in mental depression. ( 5325569 )
1966
46
Psychopharmacological aspects of mental depression. ( 5328330 )
1966
47
Acid monoamine metabolites of cerebrospinal fluid in mental depression and mania. ( 5962034 )
1966
48
A CLINICAL EVALUATION OF PARGYLINE HYDROCHLORIDE (EUTONYL) IN THE MANAGEMENT OF MENTAL DEPRESSION. ( 14309088 )
1965
49
Pargyvine hydrochloride: a new agent for the control of hypertension and mental depression. ( 13983943 )
1963
50
Treatment of recurrent mental depression with imipramine. ( 13862250 )
1961
Sources

Variations for Mental Depression

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Sources

Expression for Mental Depression

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Search GEO for disease gene expression data for Mental Depression.
Sources

Pathways for Mental Depression

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Pathways related to Mental Depression according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
12.34 COMT DCTN1 HTR1A POMC TPH2
3
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.91 BDNF GATA3 HTR1A HTR2A MAOA SLC6A4
4
Interleukin-4 and 13 signaling 66
11.77 GATA3 MAOA POMC
5
Monoamine GPCRs 1
Show member pathways
 11.73 HTR1A HTR2A HTR2C HTR7
6
Glucocorticoid receptor regulatory network 1
11.58 FKBP5 GATA3 POMC
7
Imipramine/Desipramine Pathway, Pharmacokinetics 61
Show member pathways
 11.55 COMT SLC6A2 SLC6A4
8
Serotonergic synapse 37
11.55 HTR1A HTR2A HTR2C HTR7 MAOA SLC6A4
9
Monoamine Transport 1
Show member pathways
 11.19 MAOA SLC6A2 SLC6A4 TPH2
10
Neurotransmitter Clearance In The Synaptic Cleft 66
Show member pathways
 10.91 COMT MAOA SLC6A4
11
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling 1
10.85 HTR2A HTR2C
12
noradrenaline and adrenaline degradation 1
Show member pathways
 10.7 COMT MAOA
13
Dopamine metabolism 1
10.66 COMT MAOA
14
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics 61
10.61 HTR1A HTR2A HTR2C HTR7 MAOA SLC6A4
15
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics 61
10.28 CRH POMC
Sources

GO Terms for Mental Depression

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Cellular components related to Mental Depression according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.1 BDNF COMT HTR1A HTR2A HTR2C HTR7

Biological processes related to Mental Depression according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 female pregnancy GO:0007565 9.81 COMT CRH OXT
2 circadian rhythm GO:0007623 9.81 HTR7 SLC6A4 TPH2
3 chemical synaptic transmission GO:0007268 9.73 CRH HTR1A HTR2A HTR2C HTR7 SLC6A2
4 memory GO:0007613 9.71 BDNF HTR2A OXT SLC6A4
5 behavioral fear response GO:0001662 9.69 DPP4 HTR1A HTR2C
6 response to estrogen GO:0043627 9.67 COMT CRH GATA3 TPH2
7 smooth muscle contraction GO:0006939 9.65 HTR2A HTR7
8 locomotory exploration behavior GO:0035641 9.64 CRH DPP4
9 sleep GO:0030431 9.63 HTR2A OXT
10 response to pain GO:0048265 9.63 COMT CRH SLC6A2
11 regulation of behavior GO:0050795 9.62 HTR1A HTR2A
12 neurotransmitter catabolic process GO:0042135 9.62 COMT MAOA
13 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.62 HTR1A HTR2A HTR2C HTR7
14 catecholamine metabolic process GO:0006584 9.61 COMT MAOA
15 regulation of appetite GO:0032098 9.61 HTR2C POMC
16 vasoconstriction GO:0042310 9.61 HTR1A HTR7 SLC6A4
17 monoamine transport GO:0015844 9.59 SLC6A2 SLC6A4
18 dopamine catabolic process GO:0042420 9.58 COMT MAOA
19 regulation of hormone secretion GO:0046883 9.58 HTR1A HTR2A
20 dopamine uptake involved in synaptic transmission GO:0051583 9.57 SLC6A2 SLC6A4
21 sperm ejaculation GO:0042713 9.56 OXT SLC6A4
22 response to ether GO:0045472 9.55 CRH OXT
23 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 9.54 HTR1A HTR7
24 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 9.52 HTR2A HTR2C
25 regulation of serotonin secretion GO:0014062 9.49 CRH HTR1A
26 phospholipase C-activating serotonin receptor signaling pathway GO:0007208 9.48 HTR2A HTR2C
27 behavior GO:0007610 9.33 HTR1A HTR2A HTR2C
28 response to drug GO:0042493 9.17 COMT CRH GATA3 HTR2A HTR2C SLC6A2
29 serotonin receptor signaling pathway GO:0007210 9.13 HTR1A HTR2A HTR2C
30 G-protein coupled receptor signaling pathway GO:0007186 10.14 CRH HTR1A HTR2A HTR2C HTR7 OXT

Molecular functions related to Mental Depression according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.61 CRH OXT POMC
2 neuropeptide hormone activity GO:0005184 9.5 CRH OXT POMC
3 neurotransmitter:sodium symporter activity GO:0005328 9.46 SLC6A2 SLC6A4
4 neurotransmitter receptor activity GO:0030594 9.46 HTR1A HTR2A HTR2C HTR7
5 monoamine transmembrane transporter activity GO:0008504 9.4 SLC6A2 SLC6A4
6 dopamine:sodium symporter activity GO:0005330 9.37 SLC6A2 SLC6A4
7 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding GO:0071886 9.26 HTR2A HTR2C
8 G-protein coupled serotonin receptor activity GO:0004993 9.26 HTR1A HTR2A HTR2C HTR7
9 serotonin binding GO:0051378 8.92 HTR1A HTR2A HTR2C HTR7
Sources

Sources for Mental Depression

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
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17 ExPASy
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