Mental Depression disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MNT002 MIFTS: 57	Mental Depression Categories: Mental diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Mental Depression

MalaCards integrated aliases for Mental Depression:

Name: Mental Depression ¹² ¹⁵ ⁷¹

Depressive Disorder ⁷¹

Depression ⁴³

Classifications:

MalaCards categories:
Anatomical: Mental diseases Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Mental and behavioural disorders

Mood [affective] disorders

Depressive episode

Depressive episode, unspecified

Recurrent depressive disorder

Recurrent depressive disorder, unspecified

External Ids:

Disease Ontology ¹² DOID:1596

MeSH ⁴³ D003863

NCIt ⁴⁹ C2982

SNOMED-CT ⁶⁷ 41006004

ICD10 ³² F32.9 F33.9

UMLS ⁷¹ C0011570 C0011581

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Summaries for Mental Depression

MalaCards based summary : Mental Depression, also known as depressive disorder, is related to major depressive disorder and postpartum depression, and has symptoms including dejection emotional, depressed reaction and depression aggravated. An important gene associated with Mental Depression is DCTN1 (Dynactin Subunit 1), and among its related pathways/superpathways are cAMP signaling pathway and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Valsartan and Reboxetine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and testes, and related phenotypes are behavior/neurological and endocrine/exocrine gland

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Related Diseases for Mental Depression

Diseases related to Mental Depression via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2252)

#	Related Disease	Score	Top Affiliating Genes
1	major depressive disorder	35.0	SLC6A4 POMC OXT MAOA HTR2C HTR2A
2	postpartum depression	34.7	SLC6A4 OXT MAOA LIPA HTR1A CRH
3	atypical depressive disorder	34.4	SLC6A4 SERPINA3 POMC MAOA HTR2C HTR2A
4	bipolar disorder	34.1	SLC6A4 PRODH MAOA HTR2C HTR2A HTR1A
5	neurotic disorder	33.8	SLC6A4 MAOA HTR2A HTR1A BDNF
6	schizoaffective disorder	33.3	SLC6A4 PRODH HTR2A HTR1A COMT BDNF
7	depression	33.2	SLC6A4 MAOA HTR2C HTR2A HTR1A CRH
8	fibromyalgia	33.1	SLC6A4 POMC HTR2A CRH COMT BDNF
9	dysthymic disorder	33.1	WASF1 SLC6A4 MAOA LIPA HTR2A HTR1A
10	melancholia	33.1	SLC6A4 POMC MAOA HTR2A HTR1A CRH
11	anxiety	33.0	SLC6A4 PRODH POMC OXT MAOA HTR2C
12	eating disorder	33.0	SLC6A4 POMC HTR2C HTR2A CRH COMT
13	sleep apnea	33.0	SLC6A4 HTR2C HTR2A BDNF
14	dementia	32.9	SERPINA3 MAOA HTR2A HTR1A COMT BDNF
15	restless legs syndrome	32.9	SLC6A4 POMC MAOA COMT
16	asperger syndrome	32.9	SLC6A4 OXT COMT BDNF
17	mood disorder	32.9	SLC6A4 PRODH POMC MAOA HTR2C HTR2A
18	body dysmorphic disorder	32.9	SLC6A4 MAOA HTR2A
19	supranuclear palsy, progressive, 1	32.8	SERPINA3 MIR9-1 DCTN1
20	gilles de la tourette syndrome	32.8	SLC6A4 MAOA HTR2A HTR1A COMT BDNF
21	bipolar i disorder	32.8	SLC6A4 HTR2C HTR2A HTR1A COMT BDNF
22	schizotypal personality disorder	32.8	WASF1 PRODH COMT
23	alcohol use disorder	32.8	WASF1 SLC6A4 PRODH HTR2C HTR2A HTR1A
24	borderline personality disorder	32.7	SLC6A4 MAOA HTR2C HTR2A HTR1A CRH
25	migraine with or without aura 1	32.6	SLC6A4 POMC OXT MAOA HTR2C HTR2A
26	obsessive-compulsive disorder	32.5	SLC6A4 POMC OXT MAOA HTR2C HTR2A
27	parkinson disease, late-onset	32.5	SLC6A4 SERPINA3 PRODH MIRLET7D MIR9-1 MAOA
28	bulimia nervosa	32.4	SLC6A4 POMC OXT MAOA HTR2C HTR2A
29	schizophrenia	32.4	SLC6A4 SERPINA3 PRODH POMC OXT MIR9-1
30	autism spectrum disorder	32.3	SLC6A4 PRODH POMC OXT MIR598 MAOA
31	endogenous depression	32.3	SLC6A4 POMC OXT MAOA LIPA HTR2C
32	avoidant personality disorder	32.2	WASF1 SLC6A4 MAOA
33	generalized anxiety disorder	32.1	SLC6A4 MAOA HTR2C HTR2A HTR1A COMT
34	personality disorder	32.1	SLC6A4 MAOA HTR2C HTR2A HTR1A CRH
35	acute stress disorder	32.1	SLC6A4 SERPINA3 POMC CRH BDNF
36	adjustment disorder	31.9	SLC6A4 HTR2A BDNF
37	alexithymia	31.9	SLC6A4 OXT HTR1A COMT
38	arteries, anomalies of	31.9	SERPINA3 MIRLET7D MIR9-1 H2AC18
39	post-traumatic stress disorder	31.8	SLC6A4 POMC MAOA HTR2A CRH COMT
40	panic disorder	31.8	SLC6A4 POMC MAOA HTR2C HTR2A HTR1A
41	physical disorder	31.8	PRODH MIR9-1 H2AC18
42	conduct disorder	31.8	SLC6A4 POMC MAOA COMT
43	alcohol dependence	31.7	SLC6A4 POMC OXT MAOA HTR2C HTR2A
44	agoraphobia	31.7	WASF1 SLC6A4 MAOA HTR2A HTR1A COMT
45	hypochondriasis	31.7	SLC6A4 POMC HTR2A HTR1A BDNF
46	substance abuse	31.6	WASF1 SLC6A4 SERPINA3 PRODH MAOA HTR2A
47	social phobia	31.6	WASF1 SLC6A4 SERPINA3 PRODH OXT MAOA
48	somatization disorder	31.6	SLC6A4 OXT HTR2A HTR1A CRH
49	alzheimer disease	31.5	SLC6A4 SERPINA3 OXT MAOA HTR2C HTR2A
50	drug dependence	31.5	SLC6A4 POMC CRH BDNF

Graphical network of the top 20 diseases related to Mental Depression:

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Symptoms & Phenotypes for Mental Depression

UMLS symptoms related to Mental Depression:

dejection emotional, depressed reaction, depression aggravated, affective symptoms, behavioral symptoms, schizophrenic language, depressive symptoms, depressed - symptom

MGI Mouse Phenotypes related to Mental Depression:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.1	BDNF COMT CRH DCTN1 HTR1A HTR2A
2	endocrine/exocrine gland	MP:0005379	9.81	BDNF COMT CRH DPP4 HTR2A LIPA
3	homeostasis/metabolism	MP:0005376	9.77	BDNF COMT CRH DCTN1 DPP4 HTR1A
4	nervous system	MP:0003631	9.44	BDNF COMT CRH DCTN1 HTR1A HTR2C

Sources

Drugs & Therapeutics for Mental Depression

Drugs for Mental Depression (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 971)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Valsartan

Approved, Investigational

Phase 4

137862-53-4

60846

Reboxetine

Approved, Experimental

Phase 4

71620-89-8, 98769-81-4

123628 65856

Methylphenidate

Approved, Investigational

Phase 4

113-45-1

4158

Prucalopride

Approved

Phase 4

179474-81-8

Norethindrone

Approved

Phase 4

68-22-4

6230

Mineral oil

Approved, Vet_approved

Phase 4

8042-47-5

Methimazole

Approved

Phase 4

60-56-0

1349907

Trimebutine

Approved

Phase 4

39133-31-8

Rabeprazole

Approved, Investigational

Phase 4

117976-89-3

5029

Loperamide

Approved

Phase 4

53179-11-6

3955

Lactulose

Approved

Phase 4

4618-18-2

11333

Parecoxib

Approved

Phase 4

198470-84-7

Moxonidine

Approved, Investigational

Phase 4

75438-57-2

4810

Irbesartan

Approved, Investigational

Phase 4

138402-11-6

3749

Naltrexone

Approved, Investigational, Vet_approved

Phase 4

16590-41-3

5360515

Ethanol

Approved

Phase 4

64-17-5

702

Dextromethorphan

Approved

Phase 4

125-71-3

5360696 5362449

Lithium carbonate

Approved

Phase 4

554-13-2

Desipramine

Approved, Investigational

Phase 4

50-47-5

2995

Eszopiclone

Approved, Investigational

Phase 4

138729-47-2

969472

Tranylcypromine

Approved, Investigational

Phase 4

155-09-9

441233

Nortriptyline

Approved

Phase 4

72-69-5

4543

Zinc

Approved, Investigational

Phase 4

7440-66-6

32051

Simvastatin

Approved

Phase 4

79902-63-9

54454

Modafinil

Approved, Investigational

Phase 4

68693-11-8

4236

Ropinirole

Approved, Investigational

Phase 4

91374-20-8, 91374-21-9

5095 497540

Riluzole

Approved, Investigational

Phase 4

1744-22-5

5070

Memantine

Approved, Investigational

Phase 4

19982-08-2

4054

Acetylcysteine

Approved, Investigational

Phase 4

616-91-1

12035

leucovorin

Approved

Phase 4

58-05-9

6006 143

Iloperidone

Approved

Phase 4

133454-47-4

71360

Calcium carbonate

Approved, Investigational

Phase 4

471-34-1

Acamprosate

Approved, Investigational

Phase 4

77337-76-9

71158

Levodopa

Approved

Phase 4

59-92-7

6047

Peginterferon alfa-2a

Approved, Investigational

Phase 4

198153-51-4

5360545

Ribavirin

Approved

Phase 4

36791-04-5

37542

Medroxyprogesterone acetate

Approved, Investigational

Phase 4

71-58-9

Isocarboxazid

Approved

Phase 4

59-63-2

3759

Doxepin

Approved, Investigational

Phase 4

1668-19-5

667477 667468

Protriptyline

Approved

Phase 4

438-60-8

4976

Trimipramine

Approved

Phase 4

739-71-9

5584 4055

Acetaminophen

Approved

Phase 4

103-90-2

1983

Zolpidem

Approved

Phase 4

82626-48-0

5732

Carbamazepine

Approved, Investigational

Phase 4

298-46-4

2554

Clonidine

Approved

Phase 4

4205-90-7

2803

Terazosin

Approved

Phase 4

63590-64-7

5401

Prazosin

Approved

Phase 4

19216-56-9

4893

Codeine

Approved, Illicit

Phase 4

76-57-3

5284371

Ranibizumab

Approved

Phase 4

347396-82-1

459903

Pravastatin

Approved

Phase 4

81093-37-0

54687

Interventional clinical trials:

(show top 50) (show all 10000)

#	Name	Status	NCT ID	Phase	Drugs
1	Phase 4 Study of Escitalopram Treatment and Biomarkers in Major Depressive Disorder	Unknown status	NCT01997580	Phase 4	escitalopram
2	Vortioxetine Versus Placebo in Major Depressive Disorder Comorbid With Social Anxiety Disorder	Unknown status	NCT02294305	Phase 4	Vortioxetine;Placebo
3	The Effect and Reliability of Escitalopram in the Treatment of Adolescents With Major Depressive Disorder or Anxiety Disorders	Unknown status	NCT03122158	Phase 4	Escitalopram
4	Role of Inflammation Factors and Insulin Resistance in the Pathophysiology and Treatment Response of Major Depressive Disorder	Unknown status	NCT01699490	Phase 4	Fluoxetine + Valsartan;Fluoxetine + Placebo
5	Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder	Unknown status	NCT02051413	Phase 4	Venlafaxine extended release
6	Pharmacogenomics Studies of Antidepressants	Unknown status	NCT01204086	Phase 4	Venlafaxine;Fluoxetine
7	Phase 4 Study on the Effect of Partial Sleep Deprivation on Cognition and the IL-6-gp130-System in Individuals With Major Depression	Unknown status	NCT00291239	Phase 4
8	Clinical Trial of the Use of Ketamine in Treatment Resistant Depression	Unknown status	NCT02610712	Phase 4	Ketamine
9	Dose Response Effects of Estrogen Augmentation in Mood & Memory in Perimenopausal Depression	Unknown status	NCT00229450	Phase 4	estrogen
10	Randomized，Controlled and Open-label Study of Buspirone add-on Treatment in Patients With Major Depression Disorder	Unknown status	NCT02273154	Phase 4	Buspirone;Paroxetine
11	Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder	Unknown status	NCT01460212	Phase 4	SSRI antidepressants
12	Exploring Alterations of Central Autonomic Modulation in Patients With Bipolar Depression	Unknown status	NCT01213121	Phase 4	Quetiapine
13	Inflammatory Markers and Cognitive Function in Major Depression:a Pilot Study	Unknown status	NCT01391221	Phase 4	Duloxetine
14	A Dimensional Approach to Evaluate Reward Processing in Major Depressive Disorder Before and After Treatment With Desvenlafaxine	Unknown status	NCT02859103	Phase 4	Desvenlafaxine
15	Effect of Escitalopram vs. Reboxetine on Somatic and Visceral Sensitivity of Patients With Major Depressive Disorder: a Randomized, Double Blind Clinical Trial	Unknown status	NCT00209807	Phase 4	escitalopram;Reboxetine
16	Escitalopram and Sleep Architecture in Patients With Major Depressive Disorder	Unknown status	NCT00442481	Phase 4	Escitalopram
17	Duloxetine for the Treatment of Major Depression in Midlife Women: Effects on Brain Structure and Functioning, Mood, and Quality of Life	Unknown status	NCT00889369	Phase 4	Duloxetine
18	Escitalopram Treatment of Major Depression in Diabetes Mellitus: An Open Label	Unknown status	NCT00650897	Phase 4	Escitalopram
19	Turgut Ozal Medical Center Department of Anesthesiology and Reanimation	Unknown status	NCT02267980	Phase 4	Sevoflurane;Ketamine;Saline
20	A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar I and II Depression.	Unknown status	NCT00335205	Phase 4	ropinirole
21	A Comparative Trial of TMS Approaches to Treating Depression	Unknown status	NCT01906905	Phase 4
22	Hyperventilation and ECT Seizure Duration: Effects on Cerebral Oxygen Saturation, and Therapeutic Outcome With Comparisons Between Etomidate and Ketamine in Patients With Major Depressive Disorder	Unknown status	NCT02924090	Phase 4	Etomidate;Ketamine
23	White Matter Structure and Response to Treatment With Antidepressants: a Study of Desvenlafaxine in Major Depression. A Pilot Study	Unknown status	NCT01492621	Phase 4	Desvenlafaxine
24	Sequence Towards Remission in Depression	Unknown status	NCT01628783	Phase 4	escitalopram 10 mg;Placebo
25	Behandlung Von Leichten Und Unterschwelligen Depressionen. Eine Randomisierte, Kontrollierte Studie Zum Wirksamkeitsnachweis Eines Serotonin-Wiederaufnahme-Hemmers (SSRI), Einer Kognitiven Verhaltenstherapie Und Einer Freien Therapiewahl ("Treatment of Mild and Subthreshold Depressive Disorders". A Randomized, Controlled Trial on the Efficacy of a Serotonin-Reuptake-Inhibitor (SSRI), a Cognitive-Behavioral Therapy and of Free Choice Between SSRI and CBT")	Unknown status	NCT00226642	Phase 4	Sertralin;Placebo
26	A Randomised Trial Investigating the Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder.	Unknown status	NCT01483053	Phase 4	Agomelatine;Escitalopram
27	Algorithm Guided Treatment Strategies for Major Depressive Disorder	Unknown status	NCT01764867	Phase 4	Escitalopram;Mirtazapine;Fluoxetine;Citalopram;Escitalopram;Paroxetine;Sertraline;Fluvoxamine;Venlafaxine;Duloxetine;Mirtazapine;Bupropion;Trazodone
28	Evaluation of the Efficacy of Repetitive Transcranial Magnetic Stimulation on Cognitive, Anxiety and Depressive Symptoms in Patients Diagnosed With Major Depressive Disorder	Unknown status	NCT02213016	Phase 4
29	Neurochemical,Metabonomics and Neuroimaging Characterization of TCM Diagnostic Subtypes of Major Depression Disorder	Unknown status	NCT02346682	Phase 4	venlafaxine
30	A Randomized Controlled Study Comparing Fluoxetine With Bupropion for Impulsivity and Suicidality in Patients With Major Depressive Disorder and Comorbid Alcoholism (Abuse or Dependence)	Unknown status	NCT00449007	Phase 4	fluoxetine;bupropion
31	Exploratory Study to Assess the Efficacy of Escitalopram Versus Placebo in the Treatment of Depressive Syndrome in Alzheimer’s Disease, Vascular Dementia and Mixed Vascular and Alzheimer’s Dementia	Unknown status	NCT00229333	Phase 4	Escitalopram
32	THE AIUNI - Integral Assessment in Unipolar Depression	Unknown status	NCT02268487	Phase 4	Sertraline
33	A Double-Blind, Placebo-Controlled Study of Escitalopram in the Prevention of Depression in Patients With Acute Coronary Syndrome	Unknown status	NCT00140257	Phase 4	Escitalopram
34	The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope	Unknown status	NCT01357967	Phase 4	SSRI monotherapy;Seroquel XR adjunctive
35	A Randomized Controlled Trial of Antidepressant Maintenance for Major Depression Following Mild Traumatic Brain Injury	Unknown status	NCT00162916	Phase 4	citalopram;Placebo
36	a Randomized, Double Blind, Placebo-controlled, Multicenter Clinical Trial of Efficacy and Safety of Shu Gan yi Yang Capsule in the Treatment of Depression Associated With Erectile Dysfunction (Stagnation of Liver qi and Kidney Deficiency)	Unknown status	NCT03290313	Phase 4	shu gan yi yang capsule;shu gan yi yang capsule simulation agent
37	Hippocampal Volume in Young Patients With Major Depression Before and After Combined Antidepressive Therapy - a Monocentric, Double-Blind, Placebo-Controlled Trial	Unknown status	NCT00150839	Phase 4	Mirtazapine;Venlafaxine
38	A Multicenter, Double Blind Trial to Compare the Efficacy and Safety of Escitalopram With Placebo in Patients With Acute Stroke for the Prevention of Poststroke Depression and Related Symptoms (Emotional Incontinence, Anger Proneness), and for Improvement of Neurologic, Cognitive Function and Quality of Life	Unknown status	NCT01278498	Phase 4	Escitalopram;sugar pill
39	Group Mindfulness-Based Cognitive Therapy for the Treatment of Late-Life Depression and Anxiety Symptoms in Primary Care: A Randomized Controlled Trial	Unknown status	NCT02777905	Phase 4
40	Treatment Prediction in Adolescent and Adult Depression	Unknown status	NCT00106197	Phase 4	Bupropion
41	Brain Mechanisms and Targeting Insomnia in Major Depression	Unknown status	NCT00628914	Phase 4	escitalopram and eszopiclone;Escitalopram, eszopiclone, and placebo;Escitalopram
42	TMSFOS: Preliminary Study to Investigate the Effect of rTMS and SSRI Antidepressants on Leukocyte Expression of the C-FOS and DUSP1 Genes in Patients Treated for Depression	Unknown status	NCT02042573	Phase 4	SSRI (SEROPLEX ou ZOLOFT)
43	Phase 4 Study of Vitamin D3 Supplementation for Outcomes in Patients With Unipolar Depression	Unknown status	NCT01390662	Phase 4
44	Antidepressant Treatments During Pregnancy and Lactation: Prediction of Drug Exposure Through Breastfeeding and Evaluation of Drug Effect on the Neonatal Adaptation and the Development of the Young Child	Unknown status	NCT01796132	Phase 4	SSRI/SNRI
45	Cymbalta for Depression as a Complication of Bereavement	Unknown status	NCT00658931	Phase 4	Drug treatment with Cymbalta
46	Collaborative Care for Depressed Elders in China	Unknown status	NCT01287494	Phase 4	Sertraline
47	Phase 3 Reboxetine Treatment in Depressed Children and Adolescents an 8-Week, Open Study	Unknown status	NCT00426946	Phase 4	Reboxetine
48	A 12 Week, Open Label, Efficacy and Safety Study of Desvenlafaxine in the Treatment of Vascular Depression	Unknown status	NCT01974934	Phase 4	Desvenlafaxine Succinate
49	Randomized Evaluation of the Effectiveness of Lithium in Subjects With Treatment-Resistant Depression and Suicide Risk. An Independent, Pragmatic, Multicentre, Parallel-Group, Superiority Trial	Unknown status	NCT00927550	Phase 4	lithium;usual care
50	Double-Blind Randomised Investigation of Tibolone Alone or in Adjunct to Standard Antidepressant Treatment for Depression in Menopausal Women	Unknown status	NCT01470092	Phase 4	Tibolone

Search NIH Clinical Center for Mental Depression

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Alprazolam

Amitriptyline

Amitriptyline Hydrochloride

Amoxapine

Bupropion

Bupropion hydrobromide

Bupropion Hydrochloride

Buspirone

buspirone hydrochloride

Citalopram

Citalopram hydrobromide

Clomipramine

Clomipramine Hydrochloride

Desipramine

Desipramine Hydrochloride

Doxepin

Doxepin Hydrochloride

Escitalopram

Escitalopram oxalate

Fluoxetine

Fluoxetine Hydrochloride

Fluvoxamine

Fluvoxamine Maleate

HYPERICUM PERFORATUM (ST. JOHN'S WORT)

Imipramine

Imipramine Hydrochloride

Imipramine pamoate

Isocarboxazid

Isoflurane

Kava preparation

Lithium

Lithium Aspartate

Lithium Carbonate

lithium citrate

Lorazepam

Maprotiline

Maprotiline Hydrochloride

Methylphenidate

Methylphenidate Hydrochloride

Mirtazapine

nefazodone

Nortriptyline

Nortriptyline Hydrochloride

Paroxetine

Paroxetine Hydrochloride

Phenelzine

Phenelzine Sulfate

Pramipexole

Pramipexole dihydrochloride

Protriptyline

Protriptyline Hydrochloride

Selegiline

selegiline hydrochloride

Sertraline

Sertraline Hydrochloride

Temazepam

Tranylcypromine

Tranylcypromine sulfate

Trazodone

Trazodone Hydrochloride

Tricyclic Antidepressant [EPC]

Trimipramine

Trimipramine Maleate

venlafaxine

Venlafaxine hydrochloride

Cochrane evidence based reviews: depression

Sources

Genetic Tests for Mental Depression

Sources

Anatomical Context for Mental Depression

MalaCards organs/tissues related to Mental Depression:

⁴⁰

Brain, Heart, Testes, Breast, Cortex, Lung, Prefrontal Cortex

Sources

Publications for Mental Depression

Articles related to Mental Depression:

(show top 50) (show all 26910)

#	Title	Authors	PMID	Year
1	Improvement in hypersomnia with high frequency repetitive transcranial magnetic stimulation in depressed adolescents: Preliminary evidence from an open-label study. ⁶¹	Sonmez AI...Croarkin PE	31634515	2020
2	Seasonal affective disorder and seasonal changes in weight and sleep duration are inversely associated with plasma adiponectin levels. ⁶¹	Akram F...Postolache TT	31981963	2020
3	Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed. ⁶¹	Ousdal OT...GEMRIC	31561859	2020
4	Antidepressant Efficacy of Prolonged Intermittent Theta Burst Stimulation Monotherapy for Recurrent Depression and Comparison of Methods for Coil Positioning: A Randomized, Double-Blind, Sham-Controlled Study. ⁶¹	Li CT...Su TP	31563272	2020
5	Toward an assessment of escape/avoidance coping in depression. ⁶¹	Haskell AM...Servatius RJ	31739002	2020
6	Effects of desvenlafaxine versus placebo on MDD symptom clusters: A pooled analysis. ⁶¹	Katzman MA...Boucher M	31913085	2020
7	Fluoxetine improves behavioural deficits induced by chronic alcohol treatment by alleviating RNA editing of 5-HT2C receptors. ⁶¹	Li Z...Li B	31968217	2020
8	Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression. ⁶¹	Glanville KP...Lewis CM	31570195	2020
9	Involvement of CX3CL1/CX3CR1 in depression and cognitive impairment induced by chronic unpredictable stress and relevant underlying mechanism. ⁶¹	Liu Y...Zhang C	31765724	2020
10	Developing Predictive Biomarkers Goes Alongside Diagnostic Biotypes in Major Depressive Disorder. ⁶¹	Fu CHY	32029074	2020
11	Seeking for potential pathogenic genes of major depressive disorder in the Gene Expression Omnibus database. ⁶¹	Feng J...Mu R	31889427	2020
12	Connectivity of the Cognitive Control Network During Response Inhibition as a Predictive and Response Biomarker in Major Depression: Evidence From a Randomized Clinical Trial. ⁶¹	Tozzi L...Williams LM	31601424	2020
13	Mixed Features in Depression: The Unmet Needs of Diagnostic and Statistical Manual of Mental Disorders Fifth Edition. ⁶¹	Pacchiarotti I...Verdolini N	32008688	2020
14	Genetics of resilience: Implications from genome-wide association studies and candidate genes of the stress response system in posttraumatic stress disorder and depression. ⁶¹	Maul S...Rujescu D	31583809	2020
15	The influence of posttraumatic stress disorder and recurrent major depression on risk-taking propensity following trauma script exposure among patients with substance use disorders. ⁶¹	Vidana AG...Tull MT	31775063	2020
16	Rumination network dysfunction in major depression: A brain connectome study. ⁶¹	Zhang R...Lee TMC	31734293	2020
17	Pigment epithelium-derived factor alleviates depressive-like behaviors in mice by modulating adult hippocampal synaptic growth and Wnt pathway. ⁶¹	Tian T...Xie P	31676463	2020
18	Abnormal functional connectivity strength in first-episode, drug-naïve adult patients with major depressive disorder. ⁶¹	Shi Y...Yang H	31499128	2020
19	Approach-Avoidance Conflict in Major Depressive Disorder: Congruent Neural Findings in Humans and Nonhuman Primates. ⁶¹	Ironside M...Pizzagalli DA	31672243	2020
20	Elated or sad mood induction affects the attention of patients with a bipolar disorder less than that of patients with a depressive disorder. ⁶¹	Drueke B...Mainz V	31707921	2020
21	Cell Type-Specific Methylome-wide Association Studies Implicate Neurotrophin and Innate Immune Signaling in Major Depressive Disorder. ⁶¹	Chan RF...van den Oord EJCG	31889537	2020
22	Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation for treatment-refractory major depressive disorder: A three-arm, blinded, randomized controlled trial. ⁶¹	Dunlop K...Downar J	31711880	2020
23	Large-scale dynamic causal modeling of major depressive disorder based on resting-state functional magnetic resonance imaging. ⁶¹	Li G...Shen D	32026598	2020
24	Structural alterations associated with suicide attempts in major depressive disorder and bipolar disorder: A diffusion tensor imaging study. ⁶¹	Wei S...Wang F	31778758	2020
25	Suicidality, Depression, and the FDA: Health Inequities and the Ethical Conduct of Research. ⁶¹	Iltis AS...Deria R	32023368	2020
26	Maintaining Rapid Antidepressant Effects Following Ketamine Infusion: A Major Unmet Need. ⁶¹	Papakostas GI	32023369	2020
27	Clinical implications of directly switching antidepressants in well-treated depressed patients with treatment-emergent sexual dysfunction: a comparison between vortioxetine and escitalopram. ⁶¹	Jacobsen PL...Clayton A	31010445	2020
28	Nurse-Delivered Cognitive Behavioral Therapy for Adherence and Depression Among People Living With HIV (the Ziphamandla Study): Protocol for a Randomized Controlled Trial. ⁶¹	Joska JA...Safren SA	32012114	2020
29	Association of poorer dietary quality and higher dietary inflammation with greater symptom severity in depressed individuals with appetite loss. ⁶¹	Burrows K...Paulus MP	31818803	2020
30	Screening and Counseling Adolescents and Young Adults: A Framework for Comprehensive Care. ⁶¹	Klein DA...Landis CA	32003959	2020
31	Use of home health and other healthcare delivery pathways among privately insured patients with and without treatment-resistant depression. ⁶¹	Pilon D...Lefebvre P	31985319	2020
32	Association Analysis Between the rs1899663 Polymorphism of HOTAIR and Risk of Psychiatric Conditions in an Iranian Population. ⁶¹	Sayad A...Taheri M	32036581	2020
33	Machine Learning Identifies Large-Scale Reward-Related Activity Modulated by Dopaminergic Enhancement in Major Depression. ⁶¹	Liu Y...Pizzagalli DA	31784354	2020
34	A pharmacogenetic risk score for the evaluation of major depression severity under treatment with antidepressants. ⁶¹	Kanders SH...Mwinyi J	31617956	2020
35	Impact of Wartime Stress Exposures and Mental Health on Later-Life Functioning and Disability in Vietnam-Era Women Veterans: Findings From the Health of Vietnam-Era Women's Study. ⁶¹	Smith BN...Magruder KM	31714370	2020
36	Differences in the immune-inflammatory profiles of unipolar and bipolar depression. ⁶¹	Brunoni AR...Maes M	31693974	2020
37	Randomized, double-blind, placebo-controlled study to assess the efficacy and safety of vortioxetine in Japanese patients with major depressive disorder. ⁶¹	Inoue T...Inada I	31725942	2020
38	Effect of probiotic and prebiotic versus placebo on appetite in patients with major depressive disorder: post hoc analysis of a randomised clinical trial. ⁶¹	Kazemi A...Djafarian K	31338923	2020
39	Ketamine exerts a protective role in a cell-based model of major depressive disorder via the inhibition of apoptosis and inflammation and activation of the Krebs cycle. ⁶¹	Zhang W...Li M	31215856	2020
40	Prevalence and clinical correlates of psychotic depression in first-episode and drug-naïve outpatients with major depressive disorder in a Chinese Han population. ⁶¹	Zhou Y...Zhang X	31759662	2020
41	Prevalence and clinical correlates of subclinical hypothyroidism in first-episode drug-naive patients with major depressive disorder in a large sample of Chinese. ⁶¹	Lang X...Zhang XY	31759671	2020
42	A Case Report of Transcranial Magnetic Stimulation-Related Seizure in a Young Patient With Major Depressive Disorder Receiving Accelerated Transcranial Magnetic Stimulation. ⁶¹	Kallel L...Brunelin J	32040022	2020
43	Medial temporal lobe volumes in late-life depression: effects of age and vascular risk factors. ⁶¹	Taylor WD...Landman BA	30251182	2020
44	Shared and specific functional connectivity alterations in unmedicated bipolar and major depressive disorders based on the triple-network model. ⁶¹	Wang J...Huang R	30382529	2020
45	Comprehensive assessment of side effects associated with a single dose of ketamine in treatment-resistant depression. ⁶¹	Acevedo-Diaz EE...Park LT	31791675	2020
46	Alexithymia as a possible specifier of adverse outcomes: Clinical correlates in euthymic unipolar individuals. ⁶¹	Serafini G...Amore M	31969274	2020
47	Peripheral cytokine levels and response to antidepressant treatment in depression: a systematic review and meta-analysis. ⁶¹	Liu JJ...Lu L	31427752	2020
48	Evaluation of anti-depressant effects of phthalazinone-based triple-acting small molecules against 5-HT2A, 5-HT2C, and the serotonin transporter. ⁶¹	Kim J...Pae AN	31889666	2020
49	Major depressive disorder in Chinese persons with speech disability: High rates of prevalence and perceived need for mental health care but extremely low rate of use of mental health services. ⁶¹	Zhong BL...Liu LF	31818785	2020
50	Re: "The Impact of Placebo Response Rates on Clinical Trial Outcome: A Systematic Review and Meta-Analysis of Antidepressants in Children and Adolescents with Major Depressive Disorder" by Li Y, Huang J, He Y, Yang J, Lv Y, Liu H, Liang L, Zheng Q, and Li L (J Child Adolesc Psychopharmacol 29:712-720, 2019). ⁶¹	Kirsch I	31603715	2020

Sources

Genes for Mental Depression

Genes related to Mental Depression (0 elite genes):

(show top 50) (show all 54)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	DCTN1	Dynactin Subunit 1	Protein Coding	11.2	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
2	DPP4	Dipeptidyl Peptidase 4	Protein Coding	10.6	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	9.36	DISEASES inferred ¹⁵
4	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	9.13	DISEASES inferred ¹⁵
5	PRODH	Proline Dehydrogenase 1	Protein Coding	9	DISEASES inferred ¹⁵ ¹⁵
6	HTR1A	5-Hydroxytryptamine Receptor 1A	Protein Coding	8.87	DISEASES inferred ¹⁵
7	MIRLET7D	MicroRNA Let-7d	RNA Gene	8.47	DISEASES inferred ¹⁵ ¹⁵
8	HTR2A	5-Hydroxytryptamine Receptor 2A	Protein Coding	8.42	DISEASES inferred ¹⁵
9	CRH	Corticotropin Releasing Hormone	Protein Coding	8.41	DISEASES inferred ¹⁵
10	SERPINA3	Serpin Family A Member 3	Protein Coding	8.33	DISEASES inferred ¹⁵ ¹⁵
11	MAOA	Monoamine Oxidase A	Protein Coding	8.23	DISEASES inferred ¹⁵
12	H2AC18	H2A Clustered Histone 18	Protein Coding	8.14	DISEASES inferred ¹⁵ ¹⁵
13	LIPA	Lipase A, Lysosomal Acid Type	Protein Coding	8.13	DISEASES inferred ¹⁵
14	MIR598	MicroRNA 598	RNA Gene	7.94	DISEASES inferred ¹⁵ ¹⁵
15	WASF1	WASP Family Member 1	Protein Coding	7.91	DISEASES inferred ¹⁵
16	OXT	Oxytocin/Neurophysin I Prepropeptide	Protein Coding	7.9	DISEASES inferred ¹⁵
17	HTR2C	5-Hydroxytryptamine Receptor 2C	Protein Coding	7.86	DISEASES inferred ¹⁵
18	COMT	Catechol-O-Methyltransferase	Protein Coding	7.84	DISEASES inferred ¹⁵
19	POMC	Proopiomelanocortin	Protein Coding	7.83	DISEASES inferred ¹⁵
20	MIR9-1	MicroRNA 9-1	RNA Gene	7.8	DISEASES inferred ¹⁵ ¹⁵
21	MIR185	MicroRNA 185	RNA Gene	7.72	DISEASES inferred ¹⁵ ¹⁵
22	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	7.72	DISEASES inferred ¹⁵
23	WASF2	WASP Family Member 2	Protein Coding	7.69	DISEASES inferred ¹⁵
24	FKBP5	FKBP Prolyl Isomerase 5	Protein Coding	7.69	DISEASES inferred ¹⁵
25	MIR183	MicroRNA 183	RNA Gene	7.61	DISEASES inferred ¹⁵ ¹⁵
26	DRD2	Dopamine Receptor D2	Protein Coding	7.6	DISEASES inferred ¹⁵
27	CRHR1	Corticotropin Releasing Hormone Receptor 1	Protein Coding	7.58	DISEASES inferred ¹⁵
28	IL6	Interleukin 6	Protein Coding	7.56	DISEASES inferred ¹⁵
29	HTR7	5-Hydroxytryptamine Receptor 7	Protein Coding	7.55	DISEASES inferred ¹⁵
30	TPH2	Tryptophan Hydroxylase 2	Protein Coding	7.54	DISEASES inferred ¹⁵
31	TPH1	Tryptophan Hydroxylase 1	Protein Coding	7.54	DISEASES inferred ¹⁵
32	MIR144	MicroRNA 144	RNA Gene	7.52	DISEASES inferred ¹⁵ ¹⁵
33	DISC1	DISC1 Scaffold Protein	Protein Coding	7.52	DISEASES inferred ¹⁵
34	SCLY	Selenocysteine Lyase	Protein Coding	7.49	DISEASES inferred ¹⁵
35	HTR1B	5-Hydroxytryptamine Receptor 1B	Protein Coding	7.49	DISEASES inferred ¹⁵
36	SLC6A2	Solute Carrier Family 6 Member 2	Protein Coding	7.48	DISEASES inferred ¹⁵
37	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	7.37	DISEASES inferred ¹⁵
38	DRD4	Dopamine Receptor D4	Protein Coding	7.36	DISEASES inferred ¹⁵
39	SLC6A3	Solute Carrier Family 6 Member 3	Protein Coding	7.36	DISEASES inferred ¹⁵
40	CACNA1C	Calcium Voltage-Gated Channel Subunit Alpha1 C	Protein Coding	7.35	DISEASES inferred ¹⁵
41	MIR24-1	MicroRNA 24-1	RNA Gene	7.32	DISEASES inferred ¹⁵ ¹⁵
42	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	7.3	DISEASES inferred ¹⁵
43	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6	Protein Coding	7.3	DISEASES inferred ¹⁵
44	CRP	C-Reactive Protein	Protein Coding	7.3	DISEASES inferred ¹⁵
45	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	7.25	DISEASES inferred ¹⁵
46	RTN4	Reticulon 4	Protein Coding	7.2	DISEASES inferred ¹⁵
47	GRIA1	Glutamate Ionotropic Receptor AMPA Type Subunit 1	Protein Coding	7.2	DISEASES inferred ¹⁵
48	PROC	Protein C, Inactivator Of Coagulation Factors Va And VIIIa	Protein Coding	7.18	DISEASES inferred ¹⁵
49	NPAS2	Neuronal PAS Domain Protein 2	Protein Coding	7.14	DISEASES inferred ¹⁵
50	HTR3A	5-Hydroxytryptamine Receptor 3A	Protein Coding	7.13	DISEASES inferred ¹⁵

Sources

Variations for Mental Depression

Sources

Expression for Mental Depression

Search GEO for disease gene expression data for Mental Depression.

Sources

Pathways for Mental Depression

Pathways related to Mental Depression according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	cAMP signaling pathway ³⁶	12.04	POMC OXT HTR1A BDNF
2	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	11.86	SLC6A4 MAOA HTR2A HTR1A BDNF
3	Serotonergic synapse ³⁶	11.61	SLC6A4 MAOA HTR2C HTR2A HTR1A
4	Neurotransmitter Clearance In The Synaptic Cleft ⁶⁵ Show member pathways Dopamine clearance from the synaptic cleft ⁶⁵ Enzymatic degradation of dopamine by COMT ⁶⁵ Enzymatic degradation of Dopamine by monoamine oxidase ⁶⁵ melatonin degradation II ¹ Metabolism of serotonin ⁶⁵ Serotonin clearance from the synaptic cleft ⁶⁵	10.91	SLC6A4 MAOA COMT
5	noradrenaline and adrenaline degradation ¹ Show member pathways Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB ⁶⁵ dopamine degradation ¹ L-dopa degradation ¹	10.63	MAOA COMT
6	Methylphenidate Pathway, Pharmacodynamics ⁶⁰ Show member pathways Dopamine receptors ⁶⁵	10.62	SLC6A4 MAOA HTR1A COMT
7	Dopamine metabolism ¹	10.58	MAOA COMT
8	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics ⁶⁰	10.47	SLC6A4 MAOA HTR2C HTR2A HTR1A
9	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics ⁶⁰	10.21	POMC CRH

Sources

GO Terms for Mental Depression

Cellular components related to Mental Depression according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	dendrite	GO:0030425	9.02	HTR2C HTR2A HTR1A COMT BDNF

Biological processes related to Mental Depression according to GeneCards Suite gene sharing:

(show all 19)

#	Name	GO ID	Score	Top Affiliating Genes
1	chemical synaptic transmission	GO:0007268	9.86	HTR2C HTR2A HTR1A CRH
2	response to drug	GO:0042493	9.8	SLC6A4 HTR2C HTR2A CRH COMT
3	female pregnancy	GO:0007565	9.76	OXT CRH COMT
4	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	GO:0007187	9.69	HTR2C HTR2A HTR1A
5	locomotory exploration behavior	GO:0035641	9.58	DPP4 CRH
6	sleep	GO:0030431	9.57	OXT HTR2A
7	neurotransmitter catabolic process	GO:0042135	9.55	MAOA COMT
8	catecholamine metabolic process	GO:0006584	9.54	MAOA COMT
9	behavioral fear response	GO:0001662	9.54	HTR2C HTR1A DPP4
10	dopamine catabolic process	GO:0042420	9.52	MAOA COMT
11	regulation of appetite	GO:0032098	9.49	POMC HTR2C
12	sperm ejaculation	GO:0042713	9.48	SLC6A4 OXT
13	response to ether	GO:0045472	9.46	OXT CRH
14	memory	GO:0007613	9.46	SLC6A4 OXT HTR2A BDNF
15	positive regulation of phosphatidylinositol biosynthetic process	GO:0010513	9.43	HTR2C HTR2A
16	regulation of serotonin secretion	GO:0014062	9.32	HTR1A CRH
17	phospholipase C-activating serotonin receptor signaling pathway	GO:0007208	9.26	HTR2C HTR2A
18	behavior	GO:0007610	9.13	HTR2C HTR2A HTR1A
19	serotonin receptor signaling pathway	GO:0007210	8.8	HTR2C HTR2A HTR1A

Molecular functions related to Mental Depression according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	neurotransmitter receptor activity	GO:0030594	9.43	HTR2C HTR2A HTR1A
2	G protein-coupled serotonin receptor activity	GO:0004993	9.33	HTR2C HTR2A HTR1A
3	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	GO:0071886	8.96	HTR2C HTR2A
4	serotonin binding	GO:0051378	8.92	SLC6A4 HTR2C HTR2A HTR1A

Sources

Sources for Mental Depression

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

Mental Depression

Aliases & Classifications for Mental Depression

MalaCards integrated aliases for Mental Depression:

Classifications:

External Ids:

Summaries for Mental Depression

Related Diseases for Mental Depression

Diseases related to Mental Depression via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Mental Depression:

Symptoms & Phenotypes for Mental Depression

UMLS symptoms related to Mental Depression:

MGI Mouse Phenotypes related to Mental Depression:

Drugs & Therapeutics for Mental Depression

Drugs for Mental Depression (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cochrane evidence based reviews: depression

Genetic Tests for Mental Depression

Anatomical Context for Mental Depression

MalaCards organs/tissues related to Mental Depression:

Publications for Mental Depression

Articles related to Mental Depression:

Genes for Mental Depression

Genes related to Mental Depression (0 elite genes):

Variations for Mental Depression

Expression for Mental Depression

Pathways for Mental Depression

Pathways related to Mental Depression according to GeneCards Suite gene sharing:

GO Terms for Mental Depression

Cellular components related to Mental Depression according to GeneCards Suite gene sharing:

Biological processes related to Mental Depression according to GeneCards Suite gene sharing:

Molecular functions related to Mental Depression according to GeneCards Suite gene sharing:

Sources for Mental Depression

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :