MCID: MNT002
MIFTS: 57

Mental Depression

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Mental Depression

MalaCards integrated aliases for Mental Depression:

Name: Mental Depression 12 15 71
Depressive Disorder 71
Depression 43

Classifications:



External Ids:

Disease Ontology 12 DOID:1596
MeSH 43 D003863
NCIt 49 C2982
SNOMED-CT 67 41006004
ICD10 32 F32.9 F33.9
UMLS 71 C0011570 C0011581

Summaries for Mental Depression

MalaCards based summary : Mental Depression, also known as depressive disorder, is related to major depressive disorder and postpartum depression, and has symptoms including dejection emotional, depressed reaction and depression aggravated. An important gene associated with Mental Depression is DCTN1 (Dynactin Subunit 1), and among its related pathways/superpathways are cAMP signaling pathway and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Valsartan and Drospirenone have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and testes, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Related Diseases for Mental Depression

Diseases related to Mental Depression via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2244)
# Related Disease Score Top Affiliating Genes
1 major depressive disorder 35.0 SLC6A4 POMC OXT MAOA HTR2C HTR2A
2 postpartum depression 34.8 SLC6A4 OXT MAOA LIPA HTR1A CRH
3 atypical depressive disorder 34.4 SLC6A4 SERPINA3 POMC MAOA HTR2C HTR2A
4 bipolar disorder 34.1 SLC6A4 PRODH MAOA HTR2C HTR2A HTR1A
5 neurotic disorder 33.8 SLC6A4 MAOA HTR2A HTR1A BDNF
6 schizoaffective disorder 33.3 SLC6A4 PRODH HTR2A HTR1A COMT BDNF
7 depression 33.2 SLC6A4 MAOA HTR2C HTR2A HTR1A CRH
8 fibromyalgia 33.1 SLC6A4 POMC HTR2A CRH COMT BDNF
9 dysthymic disorder 33.1 WASF1 SLC6A4 MAOA LIPA HTR2A HTR1A
10 melancholia 33.1 SLC6A4 POMC MAOA HTR2A HTR1A CRH
11 anxiety 33.0 SLC6A4 PRODH POMC OXT MAOA HTR2C
12 eating disorder 33.0 SLC6A4 POMC HTR2C HTR2A CRH COMT
13 sleep apnea 33.0 SLC6A4 HTR2C HTR2A BDNF
14 dementia 32.9 SERPINA3 MAOA HTR2A HTR1A COMT BDNF
15 restless legs syndrome 32.9 SLC6A4 POMC MAOA COMT
16 asperger syndrome 32.9 SLC6A4 OXT COMT BDNF
17 mood disorder 32.9 SLC6A4 PRODH POMC MAOA HTR2C HTR2A
18 body dysmorphic disorder 32.9 SLC6A4 MAOA HTR2A
19 supranuclear palsy, progressive, 1 32.8 SERPINA3 MIR9-1 DCTN1
20 gilles de la tourette syndrome 32.8 SLC6A4 MAOA HTR2A HTR1A COMT BDNF
21 schizotypal personality disorder 32.8 WASF1 PRODH COMT
22 bipolar i disorder 32.8 SLC6A4 HTR2C HTR2A HTR1A COMT BDNF
23 alcohol use disorder 32.8 WASF1 SLC6A4 PRODH HTR2C HTR2A HTR1A
24 borderline personality disorder 32.7 SLC6A4 MAOA HTR2C HTR2A HTR1A CRH
25 migraine with or without aura 1 32.6 SLC6A4 POMC OXT MAOA HTR2C HTR2A
26 obsessive-compulsive disorder 32.5 SLC6A4 POMC OXT MAOA HTR2C HTR2A
27 parkinson disease, late-onset 32.5 SLC6A4 SERPINA3 PRODH MIRLET7D MIR9-1 MAOA
28 bulimia nervosa 32.4 SLC6A4 POMC OXT MAOA HTR2C HTR2A
29 schizophrenia 32.4 SLC6A4 SERPINA3 PRODH POMC OXT MIR9-1
30 autism spectrum disorder 32.3 SLC6A4 PRODH POMC OXT MIR598 MAOA
31 endogenous depression 32.3 SLC6A4 POMC OXT MAOA LIPA HTR2C
32 digeorge syndrome 32.3 PRODH MIR9-1 H2AC18 COMT
33 avoidant personality disorder 32.2 WASF1 SLC6A4 MAOA
34 generalized anxiety disorder 32.1 SLC6A4 MAOA HTR2C HTR2A HTR1A COMT
35 personality disorder 32.1 SLC6A4 MAOA HTR2C HTR2A HTR1A CRH
36 acute stress disorder 32.1 SLC6A4 SERPINA3 POMC CRH BDNF
37 adjustment disorder 31.9 SLC6A4 HTR2A BDNF
38 alexithymia 31.9 SLC6A4 OXT HTR1A COMT
39 arteries, anomalies of 31.9 SERPINA3 MIRLET7D MIR9-1 H2AC18
40 post-traumatic stress disorder 31.8 SLC6A4 POMC MAOA HTR2A CRH COMT
41 panic disorder 31.8 SLC6A4 POMC MAOA HTR2C HTR2A HTR1A
42 conduct disorder 31.8 SLC6A4 POMC MAOA COMT
43 physical disorder 31.8 PRODH MIR9-1 H2AC18
44 alcohol dependence 31.7 SLC6A4 POMC OXT MAOA HTR2C HTR2A
45 agoraphobia 31.7 WASF1 SLC6A4 MAOA HTR2A HTR1A COMT
46 hypochondriasis 31.7 SLC6A4 POMC HTR2A HTR1A BDNF
47 social phobia 31.6 WASF1 SLC6A4 SERPINA3 PRODH OXT MAOA
48 substance abuse 31.6 WASF1 SLC6A4 SERPINA3 PRODH MAOA HTR2A
49 somatization disorder 31.6 SLC6A4 OXT HTR2A HTR1A CRH
50 alzheimer disease 31.5 SLC6A4 SERPINA3 OXT MAOA HTR2C HTR2A

Graphical network of the top 20 diseases related to Mental Depression:



Diseases related to Mental Depression

Symptoms & Phenotypes for Mental Depression

UMLS symptoms related to Mental Depression:


dejection emotional, depressed reaction, depression aggravated, affective symptoms, behavioral symptoms, schizophrenic language, depressive symptoms, depressed - symptom

MGI Mouse Phenotypes related to Mental Depression:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 BDNF COMT CRH DCTN1 HTR1A HTR2A
2 endocrine/exocrine gland MP:0005379 9.81 BDNF COMT CRH DPP4 HTR2A LIPA
3 homeostasis/metabolism MP:0005376 9.77 BDNF COMT CRH DCTN1 DPP4 HTR1A
4 nervous system MP:0003631 9.44 BDNF COMT CRH DCTN1 HTR1A HTR2C

Drugs & Therapeutics for Mental Depression

Drugs for Mental Depression (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 967)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
2
Drospirenone Approved Phase 4 67392-87-4 68873
3
Reboxetine Approved, Experimental Phase 4 98769-81-4, 71620-89-8 123628 65856
4
Prucalopride Approved Phase 4 179474-81-8
5
Norethindrone Approved Phase 4 68-22-4 6230
6
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
7
Methimazole Approved Phase 4 60-56-0 1349907
8
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
9
Trimebutine Approved Phase 4 39133-31-8
10
Loperamide Approved Phase 4 53179-11-6 3955
11
Lactulose Approved Phase 4 4618-18-2 11333
12
Parecoxib Approved Phase 4 198470-84-7
13
Ethanol Approved Phase 4 64-17-5 702
14
Dextromethorphan Approved Phase 4 125-71-3 5360696 5362449
15
Lithium carbonate Approved Phase 4 554-13-2
16
Desipramine Approved, Investigational Phase 4 50-47-5 2995
17
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
18
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
19
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
20
Tranylcypromine Approved, Investigational Phase 4 155-09-9 441233
21
Nortriptyline Approved Phase 4 72-69-5 4543
22
Zinc Approved, Investigational Phase 4 7440-66-6 32051
23
Simvastatin Approved Phase 4 79902-63-9 54454
24
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
25
Ropinirole Approved, Investigational Phase 4 91374-20-8, 91374-21-9 497540 5095
26
Riluzole Approved, Investigational Phase 4 1744-22-5 5070
27
Memantine Approved, Investigational Phase 4 19982-08-2 4054
28
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
29
leucovorin Approved Phase 4 58-05-9 6006 143
30
Iloperidone Approved Phase 4 133454-47-4 71360
31
Calcium carbonate Approved, Investigational Phase 4 471-34-1
32
Acamprosate Approved, Investigational Phase 4 77337-76-9 71158
33
Medroxyprogesterone acetate Approved, Investigational Phase 4 71-58-9
34
Doxepin Approved, Investigational Phase 4 1668-19-5 667477 667468
35
Protriptyline Approved Phase 4 438-60-8 4976
36
Isocarboxazid Approved Phase 4 59-63-2 3759
37
Trimipramine Approved Phase 4 739-71-9 5584 4055
38
Zolpidem Approved Phase 4 82626-48-0 5732
39
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
40
Clonidine Approved Phase 4 4205-90-7 2803
41
Prazosin Approved Phase 4 19216-56-9 4893
42
Terazosin Approved Phase 4 63590-64-7 5401
43
Codeine Approved, Illicit Phase 4 76-57-3 5284371
44
Ranibizumab Approved Phase 4 347396-82-1 459903
45
Pravastatin Approved Phase 4 81093-37-0 54687
46
Dezocine Approved, Investigational Phase 4 53648-55-8 40841 3033053
47
Doxylamine Approved, Vet_approved Phase 4 469-21-6, 562-10-7 3162
48
Doxorubicin Approved, Investigational Phase 4 23214-92-8 31703
49
Rasagiline Approved Phase 4 136236-51-6 3052776
50
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775

Interventional clinical trials:

(show top 50) (show all 10000)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study of Escitalopram Treatment and Biomarkers in Major Depressive Disorder Unknown status NCT01997580 Phase 4 escitalopram
2 Vortioxetine Versus Placebo in Major Depressive Disorder Comorbid With Social Anxiety Disorder Unknown status NCT02294305 Phase 4 Vortioxetine;Placebo
3 The Effect and Reliability of Escitalopram in the Treatment of Adolescents With Major Depressive Disorder or Anxiety Disorders Unknown status NCT03122158 Phase 4 Escitalopram
4 Role of Inflammation Factors and Insulin Resistance in the Pathophysiology and Treatment Response of Major Depressive Disorder Unknown status NCT01699490 Phase 4 Fluoxetine + Valsartan;Fluoxetine + Placebo
5 Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder Unknown status NCT02051413 Phase 4 Venlafaxine extended release
6 Pharmacogenomics Studies of Antidepressants Unknown status NCT01204086 Phase 4 Venlafaxine;Fluoxetine
7 Phase 4 Study on the Effect of Partial Sleep Deprivation on Cognition and the IL-6-gp130-System in Individuals With Major Depression Unknown status NCT00291239 Phase 4
8 Clinical Trial of the Use of Ketamine in Treatment Resistant Depression Unknown status NCT02610712 Phase 4 Ketamine
9 Randomized,Controlled and Open-label Study of Buspirone add-on Treatment in Patients With Major Depression Disorder Unknown status NCT02273154 Phase 4 Buspirone;Paroxetine
10 Dose Response Effects of Estrogen Augmentation in Mood & Memory in Perimenopausal Depression Unknown status NCT00229450 Phase 4 estrogen
11 Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder Unknown status NCT01460212 Phase 4 SSRI antidepressants
12 Exploring Alterations of Central Autonomic Modulation in Patients With Bipolar Depression Unknown status NCT01213121 Phase 4 Quetiapine
13 Inflammatory Markers and Cognitive Function in Major Depression:a Pilot Study Unknown status NCT01391221 Phase 4 Duloxetine
14 A Dimensional Approach to Evaluate Reward Processing in Major Depressive Disorder Before and After Treatment With Desvenlafaxine Unknown status NCT02859103 Phase 4 Desvenlafaxine
15 Effect of Escitalopram vs. Reboxetine on Somatic and Visceral Sensitivity of Patients With Major Depressive Disorder: a Randomized, Double Blind Clinical Trial Unknown status NCT00209807 Phase 4 escitalopram;Reboxetine
16 Escitalopram and Sleep Architecture in Patients With Major Depressive Disorder Unknown status NCT00442481 Phase 4 Escitalopram
17 Duloxetine for the Treatment of Major Depression in Midlife Women: Effects on Brain Structure and Functioning, Mood, and Quality of Life Unknown status NCT00889369 Phase 4 Duloxetine
18 Escitalopram Treatment of Major Depression in Diabetes Mellitus: An Open Label Unknown status NCT00650897 Phase 4 Escitalopram
19 Turgut Ozal Medical Center Department of Anesthesiology and Reanimation Unknown status NCT02267980 Phase 4 Sevoflurane;Ketamine;Saline
20 A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar I and II Depression. Unknown status NCT00335205 Phase 4 ropinirole
21 A Comparative Trial of TMS Approaches to Treating Depression Unknown status NCT01906905 Phase 4
22 Hyperventilation and ECT Seizure Duration: Effects on Cerebral Oxygen Saturation, and Therapeutic Outcome With Comparisons Between Etomidate and Ketamine in Patients With Major Depressive Disorder Unknown status NCT02924090 Phase 4 Etomidate;Ketamine
23 White Matter Structure and Response to Treatment With Antidepressants: a Study of Desvenlafaxine in Major Depression. A Pilot Study Unknown status NCT01492621 Phase 4 Desvenlafaxine
24 Sequence Towards Remission in Depression Unknown status NCT01628783 Phase 4 escitalopram 10 mg;Placebo
25 Behandlung Von Leichten Und Unterschwelligen Depressionen. Eine Randomisierte, Kontrollierte Studie Zum Wirksamkeitsnachweis Eines Serotonin-Wiederaufnahme-Hemmers (SSRI), Einer Kognitiven Verhaltenstherapie Und Einer Freien Therapiewahl ("Treatment of Mild and Subthreshold Depressive Disorders". A Randomized, Controlled Trial on the Efficacy of a Serotonin-Reuptake-Inhibitor (SSRI), a Cognitive-Behavioral Therapy and of Free Choice Between SSRI and CBT") Unknown status NCT00226642 Phase 4 Sertralin;Placebo
26 A Randomised Trial Investigating the Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder. Unknown status NCT01483053 Phase 4 Agomelatine;Escitalopram
27 Algorithm Guided Treatment Strategies for Major Depressive Disorder Unknown status NCT01764867 Phase 4 Escitalopram;Mirtazapine;Fluoxetine;Citalopram;Escitalopram;Paroxetine;Sertraline;Fluvoxamine;Venlafaxine;Duloxetine;Mirtazapine;Bupropion;Trazodone
28 Evaluation of the Efficacy of Repetitive Transcranial Magnetic Stimulation on Cognitive, Anxiety and Depressive Symptoms in Patients Diagnosed With Major Depressive Disorder Unknown status NCT02213016 Phase 4
29 Neurochemical,Metabonomics and Neuroimaging Characterization of TCM Diagnostic Subtypes of Major Depression Disorder Unknown status NCT02346682 Phase 4 venlafaxine
30 A Randomized Controlled Study Comparing Fluoxetine With Bupropion for Impulsivity and Suicidality in Patients With Major Depressive Disorder and Comorbid Alcoholism (Abuse or Dependence) Unknown status NCT00449007 Phase 4 fluoxetine;bupropion
31 THE AIUNI - Integral Assessment in Unipolar Depression Unknown status NCT02268487 Phase 4 Sertraline
32 Exploratory Study to Assess the Efficacy of Escitalopram Versus Placebo in the Treatment of Depressive Syndrome in Alzheimer’s Disease, Vascular Dementia and Mixed Vascular and Alzheimer’s Dementia Unknown status NCT00229333 Phase 4 Escitalopram
33 A Double-Blind, Placebo-Controlled Study of Escitalopram in the Prevention of Depression in Patients With Acute Coronary Syndrome Unknown status NCT00140257 Phase 4 Escitalopram
34 The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope Unknown status NCT01357967 Phase 4 SSRI monotherapy;Seroquel XR adjunctive
35 A Randomized Controlled Trial of Antidepressant Maintenance for Major Depression Following Mild Traumatic Brain Injury Unknown status NCT00162916 Phase 4 citalopram;Placebo
36 a Randomized, Double Blind, Placebo-controlled, Multicenter Clinical Trial of Efficacy and Safety of Shu Gan yi Yang Capsule in the Treatment of Depression Associated With Erectile Dysfunction (Stagnation of Liver qi and Kidney Deficiency) Unknown status NCT03290313 Phase 4 shu gan yi yang capsule;shu gan yi yang capsule simulation agent
37 Hippocampal Volume in Young Patients With Major Depression Before and After Combined Antidepressive Therapy - a Monocentric, Double-Blind, Placebo-Controlled Trial Unknown status NCT00150839 Phase 4 Mirtazapine;Venlafaxine
38 A Multicenter, Double Blind Trial to Compare the Efficacy and Safety of Escitalopram With Placebo in Patients With Acute Stroke for the Prevention of Poststroke Depression and Related Symptoms (Emotional Incontinence, Anger Proneness), and for Improvement of Neurologic, Cognitive Function and Quality of Life Unknown status NCT01278498 Phase 4 Escitalopram;sugar pill
39 Group Mindfulness-Based Cognitive Therapy for the Treatment of Late-Life Depression and Anxiety Symptoms in Primary Care: A Randomized Controlled Trial Unknown status NCT02777905 Phase 4
40 Treatment Prediction in Adolescent and Adult Depression Unknown status NCT00106197 Phase 4 Bupropion
41 Brain Mechanisms and Targeting Insomnia in Major Depression Unknown status NCT00628914 Phase 4 escitalopram and eszopiclone;Escitalopram, eszopiclone, and placebo;Escitalopram
42 TMSFOS: Preliminary Study to Investigate the Effect of rTMS and SSRI Antidepressants on Leukocyte Expression of the C-FOS and DUSP1 Genes in Patients Treated for Depression Unknown status NCT02042573 Phase 4 SSRI (SEROPLEX ou ZOLOFT)
43 Phase 4 Study of Vitamin D3 Supplementation for Outcomes in Patients With Unipolar Depression Unknown status NCT01390662 Phase 4
44 Antidepressant Treatments During Pregnancy and Lactation: Prediction of Drug Exposure Through Breastfeeding and Evaluation of Drug Effect on the Neonatal Adaptation and the Development of the Young Child Unknown status NCT01796132 Phase 4 SSRI/SNRI
45 Cymbalta for Depression as a Complication of Bereavement Unknown status NCT00658931 Phase 4 Drug treatment with Cymbalta
46 Collaborative Care for Depressed Elders in China Unknown status NCT01287494 Phase 4 Sertraline
47 Phase 3 Reboxetine Treatment in Depressed Children and Adolescents an 8-Week, Open Study Unknown status NCT00426946 Phase 4 Reboxetine
48 A 12 Week, Open Label, Efficacy and Safety Study of Desvenlafaxine in the Treatment of Vascular Depression Unknown status NCT01974934 Phase 4 Desvenlafaxine Succinate
49 Randomized Evaluation of the Effectiveness of Lithium in Subjects With Treatment-Resistant Depression and Suicide Risk. An Independent, Pragmatic, Multicentre, Parallel-Group, Superiority Trial Unknown status NCT00927550 Phase 4 lithium;usual care
50 Double-Blind Randomised Investigation of Tibolone Alone or in Adjunct to Standard Antidepressant Treatment for Depression in Menopausal Women Unknown status NCT01470092 Phase 4 Tibolone

Search NIH Clinical Center for Mental Depression

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Alprazolam
Amitriptyline
Amitriptyline Hydrochloride
Amoxapine
Bupropion
Bupropion hydrobromide
Bupropion Hydrochloride
Buspirone
buspirone hydrochloride
Citalopram
Citalopram hydrobromide
Clomipramine
Clomipramine Hydrochloride
Desipramine
Desipramine Hydrochloride
Doxepin
Doxepin Hydrochloride
Escitalopram
Escitalopram oxalate
Fluoxetine
Fluoxetine Hydrochloride
Fluvoxamine
Fluvoxamine Maleate
HYPERICUM PERFORATUM (ST. JOHN'S WORT)
Imipramine
Imipramine Hydrochloride
Imipramine pamoate
Isocarboxazid
Isoflurane
Kava preparation
Lithium
Lithium Aspartate
Lithium Carbonate
lithium citrate
Lorazepam
Maprotiline
Maprotiline Hydrochloride
Methylphenidate
Methylphenidate Hydrochloride
Mirtazapine
nefazodone
Nortriptyline
Nortriptyline Hydrochloride
Paroxetine
Paroxetine Hydrochloride
Phenelzine
Phenelzine Sulfate
Pramipexole
Pramipexole dihydrochloride
Protriptyline
Protriptyline Hydrochloride
Selegiline
selegiline hydrochloride
Sertraline
Sertraline Hydrochloride
Temazepam
Tranylcypromine
Tranylcypromine sulfate
Trazodone
Trazodone Hydrochloride
Tricyclic Antidepressant [EPC]
Trimipramine
Trimipramine Maleate
venlafaxine
Venlafaxine hydrochloride

Cochrane evidence based reviews: depression

Genetic Tests for Mental Depression

Anatomical Context for Mental Depression

MalaCards organs/tissues related to Mental Depression:

40
Brain, Heart, Testes, Breast, Cortex, Lung, Prefrontal Cortex

Publications for Mental Depression

Articles related to Mental Depression:

(show top 50) (show all 26590)
# Title Authors PMID Year
1
Improvement in hypersomnia with high frequency repetitive transcranial magnetic stimulation in depressed adolescents: Preliminary evidence from an open-label study. 61
31634515 2020
2
Abnormal functional connectivity strength in first-episode, drug-naïve adult patients with major depressive disorder. 61
31499128 2020
3
Structural alterations associated with suicide attempts in major depressive disorder and bipolar disorder: A diffusion tensor imaging study. 61
31778758 2020
4
Pigment epithelium-derived factor alleviates depressive-like behaviors in mice by modulating adult hippocampal synaptic growth and Wnt pathway. 61
31676463 2020
5
Rumination network dysfunction in major depression: A brain connectome study. 61
31734293 2020
6
The effect of atorvastatin on cognition and mood in bipolar disorder and unipolar depression patients: A secondary analysis of a randomized controlled trial. 61
31733459 2020
7
Changes in depressed patients' self-statements. 61
30422103 2020
8
Differences in the immune-inflammatory profiles of unipolar and bipolar depression. 61
31693974 2020
9
A study combining whole-exome sequencing and structural neuroimaging analysis for major depressive disorder. 61
31706157 2020
10
A network perspective on body dysmorphic disorder and major depressive disorder. 61
31733461 2020
11
Dose increase of S-Adenosyl-Methionine and escitalopram in a randomized clinical trial for major depressive disorder. 61
31733455 2020
12
Lower midbrain dopamine transporter availability in depressed patients: Report from high-resolution PET imaging. 61
31732277 2020
13
Preliminary efficacy and mediators of interpersonal psychotherapy for reducing posttraumatic stress symptoms in an incarcerated population. 61
30857489 2020
14
Elevated expression of unfolded protein response genes in the prefrontal cortex of depressed subjects: Effect of suicide. 61
31727394 2020
15
Do interpersonal fears mediate the association between childhood maltreatment and interpersonal skills deficits? A matched cross-sectional analysis. 61
30309293 2020
16
The predictive performance of the bipolarity index in a Dutch epidemiological sample manuscript. 61
31735409 2020
17
Contribution of religion/spirituality and major depressive disorder to altruism. 61
31698251 2020
18
Connectivity patterns of cognitive control network in first episode medication-naive depression and remitted depression. 61
31770543 2020
19
Do sleep disturbances in depressed adolescents improve following psychological treatment for depression? 61
31679753 2020
20
Antidepressant resistance in adolescents with major depressive disorder: A nationwide longitudinal study. 61
31733920 2020
21
Prevalence and recognition of depressive disorders among Chinese older adults receiving primary care: A multi-center cross-sectional study. 61
31493635 2020
22
Common and distinct neural activities in frontoparietal network in first-episode bipolar disorder and major depressive disorder: Preliminary findings from a follow-up resting state fMRI study. 61
31542559 2020
23
Dysfunctional adaptive immune response in adolescents and young adults with suicide behavior. 61
31756521 2020
24
Anesthetic Management During Electroconvulsive Therapy in Children: A Systematic Review of the Available Literature. 61
31425262 2020
25
Altered plasma levels of arginine metabolites in depression. 61
31629205 2020
26
Brain oscillation-synchronized stimulation of the left dorsolateral prefrontal cortex in depression using real-time EEG-triggered TMS. 61
31631058 2020
27
Immune response to stress induction as a predictor of cognitive-behavioral therapy outcomes in adolescent mood disorders: A pilot study. 61
31634750 2020
28
Psychometric properties of the 10-item Connor-Davidson Resilience Scale (CD-RISC-10) in Chinese undergraduates and depressive patients. 61
31654919 2020
29
Depression-like behavior, hyperglycemia, oxidative stress, and neuroinflammation presented in diabetic mice are reversed by the administration of 1-methyl-3-(phenylselanyl)-1H-indole. 61
31654972 2020
30
A pilot investigation of an intensive theta burst stimulation protocol for patients with treatment resistant depression. 61
31477542 2020
31
Enhanced noradrenergic activity by yohimbine and differential fear conditioning in patients with major depression with and without adverse childhood experiences. 61
31446157 2020
32
Carbamoylated erythropoietin produces antidepressant-like effects in male and female mice. 61
31454554 2020
33
Effects of REM sleep during a daytime nap on emotional perception in individuals with and without depression. 61
31550615 2020
34
Electroencephalogram Source Connectivity in the Prediction of Electroconvulsive Therapy Outcome in Major Depressive Disorder. 61
31752533 2020
35
Decision-making of patients with major depressive disorder in the framework of action control. 61
31672088 2020
36
A frontal-vagal network theory for Major Depressive Disorder: Implications for optimizing neuromodulation techniques. 61
31668983 2020
37
Causes of drug discontinuation in patients with major depressive disorder in China. 61
31454555 2020
38
Altered Brain Entropy as a predictor of antidepressant response in major depressive disorder. 61
31563070 2020
39
Influence of comorbid anxiety symptoms on cognitive deficits in patients with major depressive disorder. 61
31493645 2020
40
Comorbidity with more anxiety disorders associated with a poorer prognosis persisting at the 10-year follow-up among patients with major depressive disorder. 61
31493646 2020
41
Peripheral blood BDNF-TrkB signaling in first-episode, drug-free patients with major depressive disorder and schizophrenia. 61
31711978 2020
42
OnabotulinumtoxinA for the treatment of major depressive disorder: a phase 2 randomized, double-blind, placebo-controlled trial in adult females. 61
31609787 2020
43
White matter microstructural differences across major depressive disorder, bipolar disorder and schizophrenia: A tract-based spatial statistics study. 61
31521864 2020
44
Using text mining to extract depressive symptoms and to validate the diagnosis of major depressive disorder from electronic health records. 61
31541973 2020
45
Welfare stigma as a risk factor for major depressive disorder: Evidence from the Supplemental Nutrition Assistance Program. 61
31493639 2020
46
Using self-reported vocational functioning measures to identify employed patients with impaired functional capacity in major depressive disorder. 61
31539692 2020
47
ROC analysis of three-dimensional psychological pain in suicide ideation and suicide attempt among patients with major depressive disorder. 61
31576558 2020
48
Impact of depression at early and late phases following acute coronary syndrome on long-term cardiac outcomes. 61
31541969 2020
49
Gender differences in trajectories of depressive symptoms across childhood and adolescence: A multi-group growth mixture model. 61
31539681 2020
50
Maternal environmental risk factors and the development of internalizing and externalizing problems in childhood: The complex role of genetic factors. 61
31444904 2020

Variations for Mental Depression

Expression for Mental Depression

Search GEO for disease gene expression data for Mental Depression.

Pathways for Mental Depression

GO Terms for Mental Depression

Cellular components related to Mental Depression according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.02 HTR2C HTR2A HTR1A COMT BDNF

Biological processes related to Mental Depression according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.86 HTR2C HTR2A HTR1A CRH
2 response to drug GO:0042493 9.8 SLC6A4 HTR2C HTR2A CRH COMT
3 female pregnancy GO:0007565 9.76 OXT CRH COMT
4 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.69 HTR2C HTR2A HTR1A
5 locomotory exploration behavior GO:0035641 9.58 DPP4 CRH
6 sleep GO:0030431 9.57 OXT HTR2A
7 neurotransmitter catabolic process GO:0042135 9.55 MAOA COMT
8 catecholamine metabolic process GO:0006584 9.54 MAOA COMT
9 behavioral fear response GO:0001662 9.54 HTR2C HTR1A DPP4
10 dopamine catabolic process GO:0042420 9.52 MAOA COMT
11 regulation of appetite GO:0032098 9.49 POMC HTR2C
12 sperm ejaculation GO:0042713 9.48 SLC6A4 OXT
13 response to ether GO:0045472 9.46 OXT CRH
14 memory GO:0007613 9.46 SLC6A4 OXT HTR2A BDNF
15 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 9.43 HTR2C HTR2A
16 regulation of serotonin secretion GO:0014062 9.32 HTR1A CRH
17 phospholipase C-activating serotonin receptor signaling pathway GO:0007208 9.26 HTR2C HTR2A
18 behavior GO:0007610 9.13 HTR2C HTR2A HTR1A
19 serotonin receptor signaling pathway GO:0007210 8.8 HTR2C HTR2A HTR1A

Molecular functions related to Mental Depression according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotransmitter receptor activity GO:0030594 9.43 HTR2C HTR2A HTR1A
2 G protein-coupled serotonin receptor activity GO:0004993 9.33 HTR2C HTR2A HTR1A
3 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding GO:0071886 8.96 HTR2C HTR2A
4 serotonin binding GO:0051378 8.92 SLC6A4 HTR2C HTR2A HTR1A

Sources for Mental Depression

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
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43 MeSH
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50 NDF-RT
53 NINDS
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56 OMIM
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61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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