Mental Depression disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MNT002 MIFTS: 58	Mental Depression Categories: Mental diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

Sources

Aliases & Classifications for Mental Depression

MalaCards integrated aliases for Mental Depression:

Name: Mental Depression ¹² ²⁹ ¹⁵ ⁷¹

Depressive Disorder ⁷¹

Depression ⁴³

Classifications:

MalaCards categories:
Anatomical: Mental diseases Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Mental and behavioural disorders

Mood [affective] disorders

Depressive episode

Depressive episode, unspecified

External Ids:

Disease Ontology ¹² DOID:1596

MeSH ⁴³ D003863

NCIt ⁴⁹ C2982

ICD10 ³² F32.9

UMLS ⁷¹ C0011570 C0011581

Sources

Summaries for Mental Depression

MalaCards based summary : Mental Depression, also known as depressive disorder, is related to major depressive disorder and postpartum depression, and has symptoms including dejection emotional, depressed reaction and depression aggravated. An important gene associated with Mental Depression is DCTN1 (Dynactin Subunit 1), and among its related pathways/superpathways are cAMP signaling pathway and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Valsartan and Reboxetine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and heart, and related phenotypes are behavior/neurological and homeostasis/metabolism

Sources

Related Diseases for Mental Depression

Diseases related to Mental Depression via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2265)

#	Related Disease	Score	Top Affiliating Genes
1	major depressive disorder	35.0	SLC6A4 POMC OXT MAOA LIPA HTR2C
2	postpartum depression	34.7	SLC6A4 POMC OXT MAOA LIPA HTR1A
3	atypical depressive disorder	34.7	SLC6A4 SERPINA3 POMC MAOA HTR2A HTR1A
4	bipolar disorder	34.2	SLC6A4 PRODH MAOA HTR2C HTR2A HTR1A
5	neurotic disorder	33.9	SLC6A4 MAOA HTR2A HTR1A BDNF
6	schizoaffective disorder	33.3	SLC6A4 PRODH HTR2A HTR1A COMT BDNF
7	depression	33.3	SLC6A4 MAOA HTR2C HTR2A HTR1A CRH
8	melancholia	33.2	SLC6A4 POMC MAOA HTR2A HTR1A CRH
9	anxiety	33.1	SLC6A4 PRODH POMC OXT MAOA HTR2C
10	fibromyalgia	33.1	SLC6A4 POMC HTR2A HTR1A CRH COMT
11	eating disorder	33.0	SLC6A4 POMC HTR2C HTR2A CRH COMT
12	dysthymic disorder	33.0	WASF1 SLC6A4 SERPINA3 PRODH MAOA LIPA
13	sleep apnea	33.0	SLC6A4 HTR2C HTR2A BDNF
14	dementia	33.0	SERPINA3 HTR2A HTR1A COMT BDNF
15	mood disorder	32.9	SLC6A4 PRODH POMC MAOA HTR2C HTR2A
16	restless legs syndrome	32.9	SLC6A4 POMC MAOA COMT
17	alcohol use disorder	32.9	WASF1 SLC6A4 HTR2C HTR2A HTR1A H2AC18
18	asperger syndrome	32.9	SLC6A4 OXT COMT BDNF
19	gilles de la tourette syndrome	32.8	SLC6A4 MAOA HTR2A HTR1A COMT BDNF
20	bipolar i disorder	32.8	SLC6A4 HTR2C HTR2A HTR1A COMT BDNF
21	body dysmorphic disorder	32.8	SLC6A4 OXT MAOA HTR2A
22	schizotypal personality disorder	32.8	WASF1 PRODH COMT
23	parkinson disease, late-onset	32.8	SLC6A4 SERPINA3 PRODH MAOA HTR2A HTR1A
24	borderline personality disorder	32.7	SLC6A4 MAOA HTR2C HTR2A HTR1A CRH
25	migraine with or without aura 1	32.6	SLC6A4 POMC OXT MAOA HTR2C HTR2A
26	schizophrenia	32.6	SLC6A4 SERPINA3 PRODH POMC OXT MAOA
27	obsessive-compulsive disorder	32.5	SLC6A4 POMC OXT MAOA HTR2C HTR2A
28	autism spectrum disorder	32.5	SLC6A4 PRODH POMC OXT MAOA HTR2C
29	bulimia nervosa	32.5	SLC6A4 POMC OXT MAOA HTR2C HTR2A
30	endogenous depression	32.4	WASF1 SLC6A4 POMC OXT MAOA LIPA
31	conversion disorder	32.3	HTR2A COMT
32	avoidant personality disorder	32.2	WASF1 SLC6A4 MAOA
33	prion disease	32.2	SERPINA3 MIRLET7D MIR144 H2AC18
34	personality disorder	32.1	SLC6A4 MAOA HTR2C HTR2A HTR1A CRH
35	dementia, lewy body	32.1	SERPINA3 COMT BDNF
36	acute stress disorder	32.1	SLC6A4 POMC OXT CRH BDNF
37	generalized anxiety disorder	32.0	SLC6A4 PRODH MAOA HTR2C HTR2A HTR1A
38	alexithymia	31.9	SLC6A4 OXT HTR1A COMT
39	adjustment disorder	31.9	SLC6A4 HTR2A HTR1A BDNF
40	panic disorder	31.9	SLC6A4 POMC MAOA HTR2C HTR2A HTR1A
41	arteries, anomalies of	31.9	SERPINA3 MIRLET7D MIR144 H2AC18
42	post-traumatic stress disorder	31.8	SLC6A4 POMC MAOA HTR2A HTR1A CRH
43	alcohol dependence	31.8	SLC6A4 POMC OXT MAOA HTR2C HTR2A
44	conduct disorder	31.8	SLC6A4 POMC MAOA COMT
45	pulmonary disease, chronic obstructive	31.7	SLC6A4 SERPINA3 MIR144 H2AC18
46	pain agnosia	31.7	POMC OXT HTR1A
47	alzheimer disease	31.7	SLC6A4 SERPINA3 MAOA HTR2A HTR1A CRH
48	somatization disorder	31.7	SLC6A4 OXT HTR2A CRH
49	social phobia	31.6	WASF1 SLC6A4 SERPINA3 PRODH OXT MAOA
50	substance abuse	31.6	WASF1 SLC6A4 SERPINA3 PRODH POMC MAOA

Graphical network of the top 20 diseases related to Mental Depression:

Sources

Symptoms & Phenotypes for Mental Depression

UMLS symptoms related to Mental Depression:

dejection emotional, depressed reaction, depression aggravated, affective symptoms, behavioral symptoms, schizophrenic language, depressive symptoms, depressed - symptom

MGI Mouse Phenotypes related to Mental Depression:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.2	BDNF COMT CRH DCTN1 HTR1A HTR2A
2	homeostasis/metabolism	MP:0005376	10	BDNF COMT CRH DCTN1 DPP4 HTR1A
3	endocrine/exocrine gland	MP:0005379	9.91	BDNF COMT CRH DPP4 HTR2A LIPA
4	integument	MP:0010771	9.61	BDNF CRH HTR2C LIPA OXT POMC
5	nervous system	MP:0003631	9.44	BDNF COMT CRH DCTN1 HTR1A HTR2C

Sources

Drugs & Therapeutics for Mental Depression

Drugs for Mental Depression (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 908)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Valsartan

Approved, Investigational

Phase 4

137862-53-4

60846

Reboxetine

Approved, Experimental

Phase 4

98769-81-4, 71620-89-8

123628 65856

Oxcarbazepine

Approved

Phase 4

28721-07-5

34312

Eleuthero

Approved, Experimental

Phase 4

Norethindrone

Approved

Phase 4

68-22-4

6230

Mineral oil

Approved, Vet_approved

Phase 4

8042-47-5

Methimazole

Approved

Phase 4

60-56-0

1349907

Trimebutine

Approved

Phase 4

39133-31-8

Rabeprazole

Approved, Investigational

Phase 4

117976-89-3

5029

Lactulose

Approved

Phase 4

4618-18-2

11333

Naltrexone

Approved, Investigational, Vet_approved

Phase 4

16590-41-3

5360515

Brexpiprazole

Approved, Investigational

Phase 4

913611-97-9

11978813

Dextromethorphan

Approved

Phase 4

125-71-3

5360696 5362449

Hydrocortisone

Approved, Vet_approved

Phase 4

50-23-7

5754

Hydrocortisone acetate

Approved, Vet_approved

Phase 4

50-03-3

Trazodone

Approved, Investigational

Phase 4

19794-93-5

5533

Desipramine

Approved, Investigational

Phase 4

50-47-5

2995

Eszopiclone

Approved, Investigational

Phase 4

138729-47-2

969472

Tranylcypromine

Approved, Investigational

Phase 4

155-09-9

441233

Riluzole

Approved, Investigational

Phase 4

1744-22-5

5070

Memantine

Approved, Investigational

Phase 4

19982-08-2

4054

Ropinirole

Approved, Investigational

Phase 4

91374-20-8, 91374-21-9

497540 5095

Acetylcysteine

Approved, Investigational

Phase 4

616-91-1

12035

leucovorin

Approved

Phase 4

58-05-9

6006 143

Zinc

Approved, Investigational

Phase 4

7440-66-6

32051

Iloperidone

Approved

Phase 4

133454-47-4

71360

Calcium carbonate

Approved, Investigational

Phase 4

471-34-1

Acamprosate

Approved, Investigational

Phase 4

77337-76-9

71158

Peginterferon alfa-2a

Approved, Investigational

Phase 4

198153-51-4

5360545

Ribavirin

Approved

Phase 4

36791-04-5

37542

Methylphenidate

Approved, Investigational

Phase 4

113-45-1

4158

Magnesium Sulfate

Approved, Investigational, Vet_approved

Phase 4

7487-88-9

24083

Omeprazole

Approved, Investigational, Vet_approved

Phase 4

73590-58-6

4594

Ondansetron

Approved

Phase 4

99614-02-5

4595

Medroxyprogesterone acetate

Approved, Investigational

Phase 4

71-58-9

Atropine

Approved, Vet_approved

Phase 4

51-55-8, 5908-99-6

174174

Doxepin

Approved, Investigational

Phase 4

1668-19-5

667477 667468

Protriptyline

Approved

Phase 4

438-60-8

4976

Trimipramine

Approved

Phase 4

739-71-9

5584 4055

Isocarboxazid

Approved

Phase 4

59-63-2

3759

Maprotiline

Approved, Investigational

Phase 4

10262-69-8

4011

Fluticasone

Approved, Experimental

Phase 4

90566-53-3

62924

Zolpidem

Approved

Phase 4

82626-48-0

5732

Carbamazepine

Approved, Investigational

Phase 4

298-46-4

2554

Gabapentin

Approved, Investigational

Phase 4

60142-96-3

3446

Clonidine

Approved

Phase 4

4205-90-7

2803

Methotrexate

Approved

Phase 4

59-05-2, 1959-05-2

126941

Liraglutide

Approved

Phase 4

204656-20-2

44147092

Hydroxychloroquine

Approved

Phase 4

118-42-3

3652

Ranibizumab

Approved

Phase 4

347396-82-1

459903

Interventional clinical trials:

(show top 50) (show all 10000)

#	Name	Status	NCT ID	Phase	Drugs
1	Phase 4 Study of Escitalopram Treatment and Biomarkers in Major Depressive Disorder	Unknown status	NCT01997580	Phase 4	escitalopram
2	Vortioxetine Versus Placebo in Major Depressive Disorder Comorbid With Social Anxiety Disorder	Unknown status	NCT02294305	Phase 4	Vortioxetine;Placebo
3	The Effect and Reliability of Escitalopram in the Treatment of Adolescents With Major Depressive Disorder or Anxiety Disorders	Unknown status	NCT03122158	Phase 4	Escitalopram
4	Role of Inflammation Factors and Insulin Resistance in the Pathophysiology and Treatment Response of Major Depressive Disorder	Unknown status	NCT01699490	Phase 4	Fluoxetine + Valsartan;Fluoxetine + Placebo
5	Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder	Unknown status	NCT02051413	Phase 4	Venlafaxine extended release
6	Pharmacogenomics Studies of Antidepressants	Unknown status	NCT01204086	Phase 4	Venlafaxine;Fluoxetine
7	Phase 4 Study on the Effect of Partial Sleep Deprivation on Cognition and the IL-6-gp130-System in Individuals With Major Depression	Unknown status	NCT00291239	Phase 4
8	Clinical Trial of the Use of Ketamine in Treatment Resistant Depression	Unknown status	NCT02610712	Phase 4	Ketamine
9	Randomized，Controlled and Open-label Study of Buspirone add-on Treatment in Patients With Major Depression Disorder	Unknown status	NCT02273154	Phase 4	Buspirone;Paroxetine
10	Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder	Unknown status	NCT01460212	Phase 4	SSRI antidepressants
11	Exploring Alterations of Central Autonomic Modulation in Patients With Bipolar Depression	Unknown status	NCT01213121	Phase 4	Quetiapine
12	Inflammatory Markers and Cognitive Function in Major Depression:a Pilot Study	Unknown status	NCT01391221	Phase 4	Duloxetine
13	A Dimensional Approach to Evaluate Reward Processing in Major Depressive Disorder Before and After Treatment With Desvenlafaxine	Unknown status	NCT02859103	Phase 4	Desvenlafaxine
14	Effect of Escitalopram vs. Reboxetine on Somatic and Visceral Sensitivity of Patients With Major Depressive Disorder: a Randomized, Double Blind Clinical Trial	Unknown status	NCT00209807	Phase 4	escitalopram;Reboxetine
15	Escitalopram and Sleep Architecture in Patients With Major Depressive Disorder	Unknown status	NCT00442481	Phase 4	Escitalopram
16	Duloxetine for the Treatment of Major Depression in Midlife Women: Effects on Brain Structure and Functioning, Mood, and Quality of Life	Unknown status	NCT00889369	Phase 4	Duloxetine
17	Escitalopram Treatment of Major Depression in Diabetes Mellitus: An Open Label	Unknown status	NCT00650897	Phase 4	Escitalopram
18	Turgut Ozal Medical Center Department of Anesthesiology and Reanimation	Unknown status	NCT02267980	Phase 4	Sevoflurane;Ketamine;Saline
19	A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar I and II Depression.	Unknown status	NCT00335205	Phase 4	ropinirole
20	A Comparative Trial of TMS Approaches to Treating Depression	Unknown status	NCT01906905	Phase 4
21	Hyperventilation and ECT Seizure Duration: Effects on Cerebral Oxygen Saturation, and Therapeutic Outcome With Comparisons Between Etomidate and Ketamine in Patients With Major Depressive Disorder	Unknown status	NCT02924090	Phase 4	Etomidate;Ketamine
22	White Matter Structure and Response to Treatment With Antidepressants: a Study of Desvenlafaxine in Major Depression. A Pilot Study	Unknown status	NCT01492621	Phase 4	Desvenlafaxine
23	Sequence Towards Remission in Depression	Unknown status	NCT01628783	Phase 4	escitalopram 10 mg;Placebo
24	Behandlung Von Leichten Und Unterschwelligen Depressionen. Eine Randomisierte, Kontrollierte Studie Zum Wirksamkeitsnachweis Eines Serotonin-Wiederaufnahme-Hemmers (SSRI), Einer Kognitiven Verhaltenstherapie Und Einer Freien Therapiewahl ("Treatment of Mild and Subthreshold Depressive Disorders". A Randomized, Controlled Trial on the Efficacy of a Serotonin-Reuptake-Inhibitor (SSRI), a Cognitive-Behavioral Therapy and of Free Choice Between SSRI and CBT")	Unknown status	NCT00226642	Phase 4	Sertralin;Placebo
25	A Randomised Trial Investigating the Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder.	Unknown status	NCT01483053	Phase 4	Agomelatine;Escitalopram
26	Algorithm Guided Treatment Strategies for Major Depressive Disorder	Unknown status	NCT01764867	Phase 4	Escitalopram;Mirtazapine;Fluoxetine;Citalopram;Escitalopram;Paroxetine;Sertraline;Fluvoxamine;Venlafaxine;Duloxetine;Mirtazapine;Bupropion;Trazodone
27	Evaluation of the Efficacy of Repetitive Transcranial Magnetic Stimulation on Cognitive, Anxiety and Depressive Symptoms in Patients Diagnosed With Major Depressive Disorder	Unknown status	NCT02213016	Phase 4
28	Neurochemical,Metabonomics and Neuroimaging Characterization of TCM Diagnostic Subtypes of Major Depression Disorder	Unknown status	NCT02346682	Phase 4	venlafaxine
29	A Randomized Controlled Study Comparing Fluoxetine With Bupropion for Impulsivity and Suicidality in Patients With Major Depressive Disorder and Comorbid Alcoholism (Abuse or Dependence)	Unknown status	NCT00449007	Phase 4	fluoxetine;bupropion
30	Clinical Psychopharmacology Division Institute of Mental Health, Peking University	Unknown status	NCT03148509	Phase 4	risperidone;aripiprazole;bupropion
31	THE AIUNI - Integral Assessment in Unipolar Depression	Unknown status	NCT02268487	Phase 4	Sertraline
32	Exploratory Study to Assess the Efficacy of Escitalopram Versus Placebo in the Treatment of Depressive Syndrome in Alzheimer’s Disease, Vascular Dementia and Mixed Vascular and Alzheimer’s Dementia	Unknown status	NCT00229333	Phase 4	Escitalopram
33	A Double-Blind, Placebo-Controlled Study of Escitalopram in the Prevention of Depression in Patients With Acute Coronary Syndrome	Unknown status	NCT00140257	Phase 4	Escitalopram
34	The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope	Unknown status	NCT01357967	Phase 4	SSRI monotherapy;Seroquel XR adjunctive
35	A Randomized Controlled Trial of Antidepressant Maintenance for Major Depression Following Mild Traumatic Brain Injury	Unknown status	NCT00162916	Phase 4	citalopram;Placebo
36	Hippocampal Volume in Young Patients With Major Depression Before and After Combined Antidepressive Therapy - a Monocentric, Double-Blind, Placebo-Controlled Trial	Unknown status	NCT00150839	Phase 4	Mirtazapine;Venlafaxine
37	a Randomized, Double Blind, Placebo-controlled, Multicenter Clinical Trial of Efficacy and Safety of Shu Gan yi Yang Capsule in the Treatment of Depression Associated With Erectile Dysfunction (Stagnation of Liver qi and Kidney Deficiency)	Unknown status	NCT03290313	Phase 4	shu gan yi yang capsule;shu gan yi yang capsule simulation agent
38	A Multicenter, Double Blind Trial to Compare the Efficacy and Safety of Escitalopram With Placebo in Patients With Acute Stroke for the Prevention of Poststroke Depression and Related Symptoms (Emotional Incontinence, Anger Proneness), and for Improvement of Neurologic, Cognitive Function and Quality of Life	Unknown status	NCT01278498	Phase 4	Escitalopram;sugar pill
39	Group Mindfulness-Based Cognitive Therapy for the Treatment of Late-Life Depression and Anxiety Symptoms in Primary Care: A Randomized Controlled Trial	Unknown status	NCT02777905	Phase 4
40	Treatment Prediction in Adolescent and Adult Depression	Unknown status	NCT00106197	Phase 4	Bupropion
41	Brain Mechanisms and Targeting Insomnia in Major Depression	Unknown status	NCT00628914	Phase 4	escitalopram and eszopiclone;Escitalopram, eszopiclone, and placebo;Escitalopram
42	TMSFOS: Preliminary Study to Investigate the Effect of rTMS and SSRI Antidepressants on Leukocyte Expression of the C-FOS and DUSP1 Genes in Patients Treated for Depression	Unknown status	NCT02042573	Phase 4	SSRI (SEROPLEX ou ZOLOFT)
43	An Exploratory Randomized Open Comparison of Oxtellar XR® vs Oxcarbazepine IR (Trileptal®) for the Treatment of Bipolar Depression	Unknown status	NCT03567681	Phase 4	Extended release oxcarbazepine vs Immediate release oxcarbazepine
44	Phase 4 Study of Vitamin D3 Supplementation for Outcomes in Patients With Unipolar Depression	Unknown status	NCT01390662	Phase 4
45	Antidepressant Treatments During Pregnancy and Lactation: Prediction of Drug Exposure Through Breastfeeding and Evaluation of Drug Effect on the Neonatal Adaptation and the Development of the Young Child	Unknown status	NCT01796132	Phase 4	SSRI/SNRI
46	Cymbalta for Depression as a Complication of Bereavement	Unknown status	NCT00658931	Phase 4	Drug treatment with Cymbalta
47	Collaborative Care for Depressed Elders in China	Unknown status	NCT01287494	Phase 4	Sertraline
48	Phase 3 Reboxetine Treatment in Depressed Children and Adolescents an 8-Week, Open Study	Unknown status	NCT00426946	Phase 4	Reboxetine
49	Effects of Low-dose Ketamine as an Adjunct to Propofol-based Anesthesia for Electroconvulsive Therapy	Unknown status	NCT02579642	Phase 4	Ketamine;Placebo
50	A 12 Week, Open Label, Efficacy and Safety Study of Desvenlafaxine in the Treatment of Vascular Depression	Unknown status	NCT01974934	Phase 4	Desvenlafaxine Succinate

Search NIH Clinical Center for Mental Depression

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Alprazolam

Amitriptyline

Amitriptyline Hydrochloride

Amoxapine

Bupropion

Bupropion hydrobromide

Bupropion Hydrochloride

Buspirone

buspirone hydrochloride

Citalopram

Citalopram hydrobromide

Clomipramine

Clomipramine Hydrochloride

Desipramine

Desipramine Hydrochloride

Doxepin

Doxepin Hydrochloride

Escitalopram

Escitalopram oxalate

Fluoxetine

Fluoxetine Hydrochloride

Fluvoxamine

Fluvoxamine Maleate

HYPERICUM PERFORATUM (ST. JOHN'S WORT)

Imipramine

Imipramine Hydrochloride

Imipramine pamoate

Isocarboxazid

Isoflurane

Kava preparation

Lithium

Lithium Aspartate

Lithium Carbonate

lithium citrate

Lorazepam

Maprotiline

Maprotiline Hydrochloride

Methylphenidate

Methylphenidate Hydrochloride

Mirtazapine

nefazodone

Nortriptyline

Nortriptyline Hydrochloride

Paroxetine

Paroxetine Hydrochloride

Phenelzine

Phenelzine Sulfate

Pramipexole

Pramipexole dihydrochloride

Protriptyline

Protriptyline Hydrochloride

Selegiline

selegiline hydrochloride

Sertraline

Sertraline Hydrochloride

Temazepam

Tranylcypromine

Tranylcypromine sulfate

Trazodone

Trazodone Hydrochloride

Tricyclic Antidepressant [EPC]

Trimipramine

Trimipramine Maleate

venlafaxine

Venlafaxine hydrochloride

Cochrane evidence based reviews: depression

Sources

Genetic Tests for Mental Depression

Genetic tests related to Mental Depression:

#	Genetic test	Affiliating Genes
1	Mental Depression ²⁹

Sources

Anatomical Context for Mental Depression

MalaCards organs/tissues related to Mental Depression:

⁴⁰

Brain, Testes, Heart, Breast, Cortex, Prefrontal Cortex, Lung

Sources

Publications for Mental Depression

Articles related to Mental Depression:

(show top 50) (show all 27847)

#	Title	Authors	PMID	Year
1	Triple reuptake inhibition of serotonin, norepinephrine, and dopamine increases the tonic activation of α2-adrenoceptors in the rat hippocampus and dopamine levels in the nucleus accumbens. ⁶¹	Jiang JL...Blier P	32474007	2020
2	Self-evaluation of negative symptoms in adolescent and young adult first psychiatric episodes. ⁶¹	Mallet J...Dubertret C	32474008	2020
3	Brain stimulation rewarding experience attenuates neonatal clomipramine-induced adulthood anxiety by reversal of pathological changes in the amygdala. ⁶¹	Chakraborty S...Shankaranarayana Rao BS	32512130	2020
4	Significance of gastrointestinal tract in the therapeutic mechanisms of exercise in depression: Synchronism between brain and intestine through GBA. ⁶¹	Liu Y...Ma J	32445660	2020
5	The structure and function of TRIP8b, an auxiliary subunit of hyperpolarization-activated cyclic-nucleotide gated channels. ⁶¹	Han Y...Chetkovich DM	32189562	2020
6	Common variants in FAN1, located in 15q13.3, confer risk for schizophrenia and bipolar disorder in Han Chinese. ⁶¹	Jian X...Shi Y	32450113	2020
7	Establishing the dose of memory support to improve patient memory for treatment and treatment outcome. ⁶¹	Lee JY...Harvey AG	31733608	2020
8	The selenocompound 1-methyl-3-(phenylselanyl)-1H-indole attenuates depression-like behavior, oxidative stress, and neuroinflammation in streptozotocin-treated mice. ⁶¹	Bampi SR...Savegnago L	32470357	2020
9	Brain structural and functional alterations in MDD patient with gastrointestinal symptoms: A resting-state MRI study. ⁶¹	Liu P...Kerang Z	32421626	2020
10	Microbiota-gut-brain axis in health and disease: Is NLRP3 inflammasome at the crossroads of microbiota-gut-brain communications? ⁶¹	Pellegrini C...Blandizzi C	32473843	2020
11	A novel pyrazole-containing selenium compound modulates the oxidative and nitrergic pathways to reverse the depression-pain syndrome in mice. ⁶¹	Birmann PT...Savegnago L	32417177	2020
12	Neuro-transcriptomic signatures for mood disorder morbidity and suicide mortality. ⁶¹	Jabbi M...Hofmann HA	32485434	2020
13	Connectome-based models can predict early symptom improvement in major depressive disorder. ⁶¹	Ju Y...Li L	32560939	2020
14	Response to a recently published systematic review on intranasal esketamine for major depressive disorder. ⁶¹	David S	32421597	2020
15	Pharmacogenetic association of bi- and triallelic polymorphisms of SLC6A4 with antidepressant response in major depressive disorder. ⁶¹	Ren F...He L	32421611	2020
16	Abnormal functional connectivity as neural biological substrate of trait and state characteristics in major depressive disorder. ⁶¹	He Z...Chen H	32335266	2020
17	PSYCHOMETRIC properties of the Chinese version of the THINC-it tool for cognitive symptoms in patients with major depressive disorder. ⁶¹	Hou Y...Shi C	32560957	2020
18	Psychiatric comorbidity in compulsive sexual behavior disorder (CSBD). ⁶¹	Ballester-Arnal R...Gil-Llario MD	32244085	2020
19	Preliminary Study of the Impact of Single-Nucleotide Polymorphisms of IL-1α, IL-1β and TNF-α Genes on the Occurrence, Severity and Treatment Effectiveness of the Major Depressive Disorder. ⁶¹	Bialek K...Sliwinski T	31912349	2020
20	Difference in binocular rivalry rate between major depressive disorder and generalized anxiety disorder. ⁶¹	Jia T...Wang K	32461128	2020
21	Women with Major Depressive Disorder, Irrespective of Comorbid Anxiety Disorders, Show Blunted Bilateral Frontal Responses during Win and Loss Anticipation. ⁶¹	Stewart JL...Aupperle RL	32421596	2020
22	Effects of transcranial direct current stimulation using miniaturized devices vs sertraline for depression in Korea: A 6 week, multicenter, randomized, double blind, active-controlled study. ⁶¹	Park S...Park JY	32464489	2020
23	Feasibility of decision rule-based treatment of comorbid youth: A pilot randomized control trial. ⁶¹	Wolff JC...Spirito A	32353635	2020
24	Efficacy of intensive short-term dynamic psychotherapy in mood disorders: A critical review. ⁶¹	Caldiroli A...Buoli M	32560931	2020
25	Inverse changes in telomere length between the blood and brain in depressive-like mice. ⁶¹	Liu Z...Xu Q	32560940	2020
26	Rate of diagnostic conversion to bipolar disorder in adults with unipolar depression and psychopharmacological treatment in the republic of Korea: A nationwide register-based study. ⁶¹	Kim EY...Ahn YM	32421610	2020
27	A temporal relationship between nonmedical opioid Use and major depression in the U.S.: A Prospective study from the National Epidemiological Survey on Alcohol and Related Conditions. ⁶¹	Li X...Leigh I	32421616	2020
28	Affective Processing Biases in Relation to Past, Current, and Future Depression in Children and Adolescents. ⁶¹	Salem T...Group TL	32421595	2020
29	A missing link between depression models: Forced swimming test, helplessness and passive coping in genetically heterogeneous NIH-HS rats. ⁶¹	Raez A...Fernandez-Teruel A	32454181	2020
30	Impaired neuronal and astroglial metabolic activity in chronic unpredictable mild stress model of depression: Reversal of behavioral and metabolic deficit with lanicemine. ⁶¹	Mishra PK...Patel AB	32360130	2020
31	Enhanced conditioning of adverse memories in the mouse modified swim test is associated with neuroinflammatory changes - Effects that are susceptible to antidepressants. ⁶¹	Pavlov D...Strekalova T	32325189	2020
32	Antidepressant-like effect of hydroalcoholic extract from barks of Rapanea ferruginea: Role of monoaminergic system and effect of its isolated compounds myrsinoic acid A and B. ⁶¹	Zimath PL...de Souza MM	32361037	2020
33	The Wistar-Kyoto rat model of endogenous depression: A tool for exploring treatment resistance with an urgent need to focus on sex differences. ⁶¹	Millard SJ...Newell KA	32145362	2020
34	Reward related ventral striatal activity and differential response to sertraline versus placebo in depressed individuals. ⁶¹	Greenberg T...Phillips ML	31462766	2020
35	Peripheral immune aberrations in fibromyalgia: A systematic review, meta-analysis and meta-regression. ⁶¹	Andres-Rodriguez L...Luciano JV	31887417	2020
36	Metacognitive beliefs in depressed in-patients: adaptation and validation of the short version of the Metacognitions Questionnaire (MCQ-30) for French clinical and non-clinical samples. ⁶¹	Baptista A...Jouvent R	32522308	2020
37	Childhood maltreatment and the clinical characteristics of major depressive disorder in adolescence and adulthood. ⁶¹	Vallati M...Harkness KL	32237880	2020
38	Major depressive disorder and cardiometabolic diseases: a bidirectional Mendelian randomisation study. ⁶¹	Tang B...Larsson SC	32270255	2020
39	Brain functional effects of electroconvulsive therapy during emotional processing in major depressive disorder. ⁶¹	Enneking V...Redlich R	32388195	2020
40	Opioid system modulation with buprenorphine/samidorphan combination for major depressive disorder: two randomized controlled studies. ⁶¹	Fava M...Pathak S	30374191	2020
41	Intrinsic connectomes are a predictive biomarker of remission in major depressive disorder. ⁶¹	Korgaonkar MS...Williams LM	31695168	2020
42	Suicidal attempts, insomnia, and major depressive disorder among family members of suicide victims in South Korea. ⁶¹	Jang J...Jeon HJ	32553386	2020
43	Ensemble Learning for Early-Response Prediction of Antidepressant Treatment in Major Depressive Disorder. ⁶¹	Pei C...Lu Q	31859419	2020
44	Editorial for "Ensemble Learning for Early-Response Prediction of Antidepressant Treatment in Major Depressive Disorder". ⁶¹	Srinath A...Girard R	32034809	2020
45	Association between cognition and suicidal ideation in patients with major depressive disorder: A longitudinal study. ⁶¹	Lan X...Ning Y	32379606	2020
46	Discovery and replication of cerebral blood flow differences in major depressive disorder. ⁶¹	Cooper CM...Trivedi MH	31388104	2020
47	Serum FAM19A5 levels: A novel biomarker for neuroinflammation and neurodegeneration in major depressive disorder. ⁶¹	Han KM...Ham BJ	32217080	2020
48	Characterization of the signature of peripheral innate immunity in women with later-life major depressive disorder. ⁶¹	Miyata S...Fukuda M	32217081	2020
49	The Association Between Adverse Childhood Experiences and Inflammation in Patients with Major Depressive Disorder: A Systematic Review. ⁶¹	Gill H...Rosenblat JD	32379599	2020
50	Association between major depressive disorder and multiple disease outcomes: a phenome-wide Mendelian randomisation study in the UK Biobank. ⁶¹	Mulugeta A...Hypponen E	31427754	2020

Sources

Genes for Mental Depression

Genes related to Mental Depression (0 elite genes):

(show top 50) (show all 57)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	DCTN1	Dynactin Subunit 1	Protein Coding	11.2	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
2	DPP4	Dipeptidyl Peptidase 4	Protein Coding	10.2	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	9.36	DISEASES inferred ¹⁵
4	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	9.16	DISEASES inferred ¹⁵
5	HTR1A	5-Hydroxytryptamine Receptor 1A	Protein Coding	8.89	DISEASES inferred ¹⁵
6	PRODH	Proline Dehydrogenase 1	Protein Coding	8.8	DISEASES inferred ¹⁵ ¹⁵
7	SERPINA3	Serpin Family A Member 3	Protein Coding	8.78	DISEASES inferred ¹⁵ ¹⁵
8	H2AC18	H2A Clustered Histone 18	Protein Coding	8.57	DISEASES inferred ¹⁵ ¹⁵
9	HTR2A	5-Hydroxytryptamine Receptor 2A	Protein Coding	8.47	DISEASES inferred ¹⁵
10	CRH	Corticotropin Releasing Hormone	Protein Coding	8.41	DISEASES inferred ¹⁵
11	MIRLET7D	MicroRNA Let-7d	RNA Gene	8.27	DISEASES inferred ¹⁵ ¹⁵
12	MAOA	Monoamine Oxidase A	Protein Coding	8.26	DISEASES inferred ¹⁵
13	LIPA	Lipase A, Lysosomal Acid Type	Protein Coding	8.17	DISEASES inferred ¹⁵
14	OXT	Oxytocin/Neurophysin I Prepropeptide	Protein Coding	8.02	DISEASES inferred ¹⁵
15	MIR185	MicroRNA 185	RNA Gene	7.97	DISEASES inferred ¹⁵ ¹⁵
16	WASF1	WASP Family Member 1	Protein Coding	7.94	DISEASES inferred ¹⁵
17	MIR144	MicroRNA 144	RNA Gene	7.92	DISEASES inferred ¹⁵ ¹⁵
18	POMC	Proopiomelanocortin	Protein Coding	7.88	DISEASES inferred ¹⁵
19	HTR2C	5-Hydroxytryptamine Receptor 2C	Protein Coding	7.87	DISEASES inferred ¹⁵
20	COMT	Catechol-O-Methyltransferase	Protein Coding	7.87	DISEASES inferred ¹⁵
21	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	7.79	DISEASES inferred ¹⁵
22	FKBP5	FKBP Prolyl Isomerase 5	Protein Coding	7.74	DISEASES inferred ¹⁵
23	WASF2	WASP Family Member 2	Protein Coding	7.71	DISEASES inferred ¹⁵
24	IL6	Interleukin 6	Protein Coding	7.69	DISEASES inferred ¹⁵
25	DRD2	Dopamine Receptor D2	Protein Coding	7.66	DISEASES inferred ¹⁵
26	CRHR1	Corticotropin Releasing Hormone Receptor 1	Protein Coding	7.63	DISEASES inferred ¹⁵
27	TPH2	Tryptophan Hydroxylase 2	Protein Coding	7.58	DISEASES inferred ¹⁵
28	MIR183	MicroRNA 183	RNA Gene	7.54	DISEASES inferred ¹⁵ ¹⁵
29	SLC6A2	Solute Carrier Family 6 Member 2	Protein Coding	7.54	DISEASES inferred ¹⁵
30	DISC1	DISC1 Scaffold Protein	Protein Coding	7.54	DISEASES inferred ¹⁵
31	TPH1	Tryptophan Hydroxylase 1	Protein Coding	7.54	DISEASES inferred ¹⁵
32	HTR7	5-Hydroxytryptamine Receptor 7	Protein Coding	7.52	DISEASES inferred ¹⁵
33	HTR1B	5-Hydroxytryptamine Receptor 1B	Protein Coding	7.51	DISEASES inferred ¹⁵
34	SCLY	Selenocysteine Lyase	Protein Coding	7.5	DISEASES inferred ¹⁵
35	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	7.43	DISEASES inferred ¹⁵
36	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6	Protein Coding	7.42	DISEASES inferred ¹⁵
37	CACNA1C	Calcium Voltage-Gated Channel Subunit Alpha1 C	Protein Coding	7.4	DISEASES inferred ¹⁵
38	MIR24-1	MicroRNA 24-1	RNA Gene	7.39	DISEASES inferred ¹⁵ ¹⁵
39	CRP	C-Reactive Protein	Protein Coding	7.38	DISEASES inferred ¹⁵
40	SLC6A3	Solute Carrier Family 6 Member 3	Protein Coding	7.37	DISEASES inferred ¹⁵
41	IL1B	Interleukin 1 Beta	Protein Coding	7.37	DISEASES inferred ¹⁵
42	DRD4	Dopamine Receptor D4	Protein Coding	7.36	DISEASES inferred ¹⁵
43	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	7.33	DISEASES inferred ¹⁵
44	OXTR	Oxytocin Receptor	Protein Coding	7.28	DISEASES inferred ¹⁵
45	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	7.27	DISEASES inferred ¹⁵
46	TNF	Tumor Necrosis Factor	Protein Coding	7.23	DISEASES inferred ¹⁵
47	GRIA1	Glutamate Ionotropic Receptor AMPA Type Subunit 1	Protein Coding	7.23	DISEASES inferred ¹⁵
48	PROC	Protein C, Inactivator Of Coagulation Factors Va And VIIIa	Protein Coding	7.2	DISEASES inferred ¹⁵
49	OPN4	Opsin 4	Protein Coding	7.14	DISEASES inferred ¹⁵
50	HTR3A	5-Hydroxytryptamine Receptor 3A	Protein Coding	7.14	DISEASES inferred ¹⁵

Sources

Variations for Mental Depression

Sources

Expression for Mental Depression

Search GEO for disease gene expression data for Mental Depression.

Sources

Pathways for Mental Depression

Pathways related to Mental Depression according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	cAMP signaling pathway ³⁶	12.04	POMC OXT HTR1A BDNF
2	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	11.86	SLC6A4 MAOA HTR2A HTR1A BDNF
3	Serotonergic synapse ³⁶	11.61	SLC6A4 MAOA HTR2C HTR2A HTR1A
4	Neurotransmitter Clearance In The Synaptic Cleft ⁶⁵ Show member pathways Dopamine clearance from the synaptic cleft ⁶⁵ Enzymatic degradation of dopamine by COMT ⁶⁵ Enzymatic degradation of Dopamine by monoamine oxidase ⁶⁵ Metabolism of serotonin ⁶⁵ Serotonin clearance from the synaptic cleft ⁶⁵	10.9	SLC6A4 MAOA COMT
5	noradrenaline and adrenaline degradation ¹ Show member pathways Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB ⁶⁵ dopamine degradation ¹ L-dopa degradation ¹ melatonin degradation II ¹	10.66	MAOA COMT
6	Methylphenidate Pathway, Pharmacodynamics ⁶⁰ Show member pathways Dopamine receptors ⁶⁵	10.62	SLC6A4 MAOA HTR1A COMT
7	Dopamine metabolism ¹	10.58	MAOA COMT
8	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics ⁶⁰	10.47	SLC6A4 MAOA HTR2C HTR2A HTR1A
9	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics ⁶⁰	10.21	POMC CRH

Sources

GO Terms for Mental Depression

Cellular components related to Mental Depression according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.76	SERPINA3 POMC OXT MIRLET7D MIR185 MIR144
2	dendrite	GO:0030425	9.35	HTR2C HTR2A HTR1A COMT BDNF
3	synapse	GO:0045202	9.1	WASF1 SLC6A4 HTR2C HTR2A HTR1A CRH

Biological processes related to Mental Depression according to GeneCards Suite gene sharing:

(show all 20)

#	Name	GO ID	Score	Top Affiliating Genes
1	chemical synaptic transmission	GO:0007268	9.88	HTR2C HTR2A HTR1A CRH
2	female pregnancy	GO:0007565	9.77	OXT CRH COMT
3	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	GO:0007187	9.69	HTR2C HTR2A HTR1A
4	response to drug	GO:0042493	9.63	SLC6A4 HTR2C HTR2A CRH COMT BDNF
5	memory	GO:0007613	9.62	SLC6A4 OXT HTR2A BDNF
6	locomotory exploration behavior	GO:0035641	9.58	DPP4 CRH
7	sleep	GO:0030431	9.57	OXT HTR2A
8	catecholamine metabolic process	GO:0006584	9.56	MAOA COMT
9	dendrite extension	GO:0097484	9.55	WASF1 BDNF
10	neurotransmitter catabolic process	GO:0042135	9.54	MAOA COMT
11	dopamine catabolic process	GO:0042420	9.52	MAOA COMT
12	regulation of appetite	GO:0032098	9.49	POMC HTR2C
13	sperm ejaculation	GO:0042713	9.48	SLC6A4 OXT
14	response to ether	GO:0045472	9.46	OXT CRH
15	positive regulation of phosphatidylinositol biosynthetic process	GO:0010513	9.43	HTR2C HTR2A
16	behavior	GO:0007610	9.43	HTR2C HTR2A HTR1A
17	regulation of serotonin secretion	GO:0014062	9.4	HTR1A CRH
18	phospholipase C-activating serotonin receptor signaling pathway	GO:0007208	9.37	HTR2C HTR2A
19	serotonin receptor signaling pathway	GO:0007210	9.13	HTR2C HTR2A HTR1A
20	behavioral fear response	GO:0001662	8.92	HTR2C HTR1A DPP4 BDNF

Molecular functions related to Mental Depression according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	neurotransmitter receptor activity	GO:0030594	9.43	HTR2C HTR2A HTR1A
2	G protein-coupled serotonin receptor activity	GO:0004993	9.33	HTR2C HTR2A HTR1A
3	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	GO:0071886	8.96	HTR2C HTR2A
4	serotonin binding	GO:0051378	8.92	SLC6A4 HTR2C HTR2A HTR1A

Sources

Sources for Mental Depression

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

Mental Depression

Aliases & Classifications for Mental Depression

MalaCards integrated aliases for Mental Depression:

Classifications:

External Ids:

Summaries for Mental Depression

Related Diseases for Mental Depression

Diseases related to Mental Depression via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Mental Depression:

Symptoms & Phenotypes for Mental Depression

UMLS symptoms related to Mental Depression:

MGI Mouse Phenotypes related to Mental Depression:

Drugs & Therapeutics for Mental Depression

Drugs for Mental Depression (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cochrane evidence based reviews: depression

Genetic Tests for Mental Depression

Genetic tests related to Mental Depression:

Anatomical Context for Mental Depression

MalaCards organs/tissues related to Mental Depression:

Publications for Mental Depression

Articles related to Mental Depression:

Genes for Mental Depression

Genes related to Mental Depression (0 elite genes):

Variations for Mental Depression

Expression for Mental Depression

Pathways for Mental Depression

Pathways related to Mental Depression according to GeneCards Suite gene sharing:

GO Terms for Mental Depression

Cellular components related to Mental Depression according to GeneCards Suite gene sharing:

Biological processes related to Mental Depression according to GeneCards Suite gene sharing:

Molecular functions related to Mental Depression according to GeneCards Suite gene sharing:

Sources for Mental Depression

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :