MCID: MNT259
MIFTS: 22

Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies

Categories: Endocrine diseases, Fetal diseases, Mental diseases, Metabolic diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

MalaCards integrated aliases for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies:

Name: Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies 56
Momes Syndrome 56 58 71
Intellectual Disability-Obesity-Prognathism-Eye and Skin Anomalies Syndrome 58

Characteristics:

Orphanet epidemiological data:

58
intellectual disability-obesity-prognathism-eye and skin anomalies syndrome
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Neonatal;

OMIM:

56
Inheritance:
autosomal recessive


HPO:

31
mental retardation, obesity, mandibular prognathism, and eye and skin anomalies:
Inheritance autosomal recessive inheritance


Classifications:

Orphanet: 58  
Rare neurological diseases
Rare endocrine diseases
Developmental anomalies during embryogenesis


Summaries for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

MalaCards based summary : Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies, also known as momes syndrome, is related to abducens palsy and astigmatism. Affiliated tissues include skin and eye, and related phenotypes are macrocephaly and obesity

More information from OMIM: 606772

Related Diseases for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

Diseases related to Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 abducens palsy 10.1
2 astigmatism 10.1
3 dermatitis, atopic 10.1
4 ptosis 10.1
5 monocular esotropia 10.1
6 blepharophimosis 10.1
7 accommodative esotropia 10.1
8 esotropia 10.1

Graphical network of the top 20 diseases related to Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies:



Diseases related to Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies

Symptoms & Phenotypes for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

Human phenotypes related to Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies:

58 31 (show all 32)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 macrocephaly 58 31 Occasional (29-5%) HP:0000256
2 obesity 58 31 Frequent (79-30%) HP:0001513
3 ptosis 58 31 Frequent (79-30%) HP:0000508
4 mandibular prognathia 58 31 Frequent (79-30%) HP:0000303
5 hallux valgus 58 31 Frequent (79-30%) HP:0001822
6 reduced visual acuity 58 31 Occasional (29-5%) HP:0007663
7 telecanthus 58 31 Occasional (29-5%) HP:0000506
8 blepharophimosis 58 31 Frequent (79-30%) HP:0000581
9 esotropia 58 31 Frequent (79-30%) HP:0000565
10 atopic dermatitis 58 31 Frequent (79-30%) HP:0001047
11 abducens palsy 58 31 Frequent (79-30%) HP:0011349
12 hyperopic astigmatism 58 31 Frequent (79-30%) HP:0000484
13 intellectual disability 31 HP:0001249
14 delayed speech and language development 31 HP:0000750
15 visual impairment 31 HP:0000505
16 intellectual disability, mild 58 Frequent (79-30%)
17 hyperactivity 58 Occasional (29-5%)
18 strabismus 58 Occasional (29-5%)
19 cone-shaped epiphysis 31 HP:0010579
20 severe global developmental delay 58 Occasional (29-5%)
21 hypoplasia of the maxilla 58 Frequent (79-30%)
22 dental crowding 31 HP:0000678
23 autistic behavior 58 Occasional (29-5%)
24 hoarse voice 58 Occasional (29-5%)
25 intellectual disability, profound 58 Occasional (29-5%)
26 crowded maxillary incisors 58 Frequent (79-30%)
27 large sella turcica 58 Occasional (29-5%)
28 cone-shaped epiphyses of the toes 58 Frequent (79-30%)
29 cone-shaped epiphyses of the 2nd toe 58 Occasional (29-5%)
30 cone-shaped epiphyses of the 3rd toe 58 Occasional (29-5%)
31 cone-shaped epiphyses of the 4th toe 58 Occasional (29-5%)
32 hyponasal speech 58 Occasional (29-5%)

Symptoms via clinical synopsis from OMIM:

56
Head And Neck Head:
macrocephaly

Head And Neck Eyes:
telecanthus
blepharophimosis
esotropia
abducens palsy
hyperopic astigmatism
more
Head And Neck Face:
prognathism

Skeletal Feet:
lateral deviation of halluces
cone-shaped epiphyses (toes 2,3, and 4)

Growth Weight:
obesity
birth weight >90th percentile

Head And Neck Teeth:
dental crowding

Neurologic Central Nervous System:
mental retardation
speech delay

Skin Nails Hair Skin:
atopic dermatitis, chronic

Clinical features from OMIM:

606772

Drugs & Therapeutics for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

Search Clinical Trials , NIH Clinical Center for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies

Genetic Tests for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

Anatomical Context for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

MalaCards organs/tissues related to Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies:

40
Skin, Eye

Publications for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

Articles related to Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies:

# Title Authors PMID Year
1
Mental retardation, obesity, mandibular prognathism with eye and skin anomalies (MOMES syndrome): a newly recognized autosomal recessive syndrome. 61 56
11746007 2001
2
Obesity syndrome, MOMES caused by deletion-duplication (4q35.1 del and 5p14.3 dup). 56
19288561 2009

Variations for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

Expression for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

Search GEO for disease gene expression data for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies.

Pathways for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

GO Terms for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

Sources for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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