MCID: MNT259
MIFTS: 20

Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies

Categories: Endocrine diseases, Fetal diseases, Mental diseases, Metabolic diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

MalaCards integrated aliases for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies:

Name: Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies 57
Momes Syndrome 57 59 72
Intellectual Disability-Obesity-Prognathism-Eye and Skin Anomalies Syndrome 59

Characteristics:

Orphanet epidemiological data:

59
intellectual disability-obesity-prognathism-eye and skin anomalies syndrome
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Neonatal;

OMIM:

57
Inheritance:
autosomal recessive


HPO:

32
mental retardation, obesity, mandibular prognathism, and eye and skin anomalies:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 57 606772
ICD10 via Orphanet 34 Q87.8
UMLS via Orphanet 73 C1847522
Orphanet 59 ORPHA397973
MedGen 42 C1847522
UMLS 72 C1847522

Summaries for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

MalaCards based summary : Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies, also known as momes syndrome, is related to abducens palsy and astigmatism. Affiliated tissues include skin and eye, and related phenotypes are macrocephaly and obesity

More information from OMIM: 606772

Related Diseases for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

Diseases related to Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 abducens palsy 10.1
2 astigmatism 10.1
3 dermatitis, atopic 10.1
4 ptosis 10.1
5 monocular esotropia 10.1
6 blepharophimosis 10.1
7 accommodative esotropia 10.1
8 esotropia 10.1

Graphical network of the top 20 diseases related to Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies:



Diseases related to Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies

Symptoms & Phenotypes for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

Human phenotypes related to Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies:

32 (show all 17)
# Description HPO Frequency HPO Source Accession
1 macrocephaly 32 HP:0000256
2 obesity 32 HP:0001513
3 ptosis 32 HP:0000508
4 intellectual disability 32 HP:0001249
5 mandibular prognathia 32 HP:0000303
6 delayed speech and language development 32 HP:0000750
7 visual impairment 32 HP:0000505
8 cone-shaped epiphysis 32 HP:0010579
9 reduced visual acuity 32 HP:0007663
10 telecanthus 32 HP:0000506
11 dental crowding 32 HP:0000678
12 blepharophimosis 32 HP:0000581
13 hallux valgus 32 HP:0001822
14 esotropia 32 HP:0000565
15 atopic dermatitis 32 HP:0001047
16 abducens palsy 32 HP:0011349
17 hyperopic astigmatism 32 HP:0000484

Symptoms via clinical synopsis from OMIM:

57
Head And Neck Head:
macrocephaly

Head And Neck Eyes:
telecanthus
blepharophimosis
esotropia
abducens palsy
hyperopic astigmatism
more
Head And Neck Face:
prognathism

Skeletal Feet:
lateral deviation of halluces
cone-shaped epiphyses (toes 2,3, and 4)

Growth Weight:
obesity
birth weight >90th percentile

Head And Neck Teeth:
dental crowding

Neurologic Central Nervous System:
mental retardation
speech delay

Skin Nails Hair Skin:
atopic dermatitis, chronic

Clinical features from OMIM:

606772

Drugs & Therapeutics for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

Search Clinical Trials , NIH Clinical Center for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies

Genetic Tests for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

Anatomical Context for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

MalaCards organs/tissues related to Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies:

41
Skin, Eye

Publications for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

Articles related to Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies:

# Title Authors PMID Year
1
Mental retardation, obesity, mandibular prognathism with eye and skin anomalies (MOMES syndrome): a newly recognized autosomal recessive syndrome. 38 8
11746007 2001
2
Obesity syndrome, MOMES caused by deletion-duplication (4q35.1 del and 5p14.3 dup). 8
19288561 2009

Variations for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

Expression for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

Search GEO for disease gene expression data for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and Skin Anomalies.

Pathways for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

GO Terms for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

Sources for Mental Retardation, Obesity, Mandibular Prognathism, and Eye and...

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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