MCID: MRL006
MIFTS: 29

Meralgia Paraesthetica, Familial

Categories: Genetic diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Meralgia Paraesthetica, Familial

MalaCards integrated aliases for Meralgia Paraesthetica, Familial:

Name: Meralgia Paraesthetica, Familial 56
Lateral Femoral Cutaneous Nerve Entrapment 52 53
Bernhardt-Roth Syndrome 52 53
Meralgia Paresthetica 52 53
Meralgia Paraesthetica Familial 52

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant


HPO:

31
meralgia paraesthetica, familial:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 56 156220
ICD10 32 G57.1
MedGen 41 C1835026
SNOMED-CT via HPO 68 263681008 88425004

Summaries for Meralgia Paraesthetica, Familial

NIH Rare Diseases : 52 Meralgia paresthetica is a condition characterized by numbness, tingling, and a burning pain in the outer thigh. Symptoms may worsen after walking or standing. The condition usually affects only one side of the body, but both sides may be affected in up to 20% of cases. Meralgia paresthetica is caused by compression of the lateral femoral cutaneous nerve, a sensory nerve to the skin on the outer thigh. Compression may be associated with various causes such as wearing tight clothing or a heavy tool belt, diabetes, nerve injury during local or regional surgery, weight gain, pregnancy, seatbelt injury, or rarely, a mass pressing on the nerve. Treatment is based on the symptoms and severity in each person. Treatment for mild symptoms may include removing the cause of nerve compression, which may involve weight loss or wearing loose clothing. More severe pain may require a nerve block to temporarily relieve symptoms. Neurogenic pain medications (such as carbamazepine or gabapentin ) typically are not as helpful but rarely relieve symptoms. People with very severe pain which is not relieved by nerve block may need to have surgery to release the nerve.

MalaCards based summary : Meralgia Paraesthetica, Familial, also known as lateral femoral cutaneous nerve entrapment, is related to paresthesia and mononeuropathy. The drugs Lidocaine and Anti-Arrhythmia Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and spinal cord, and related phenotype is abnormality of the nervous system.

NINDS : 53 Meralgia paresthetica is a disorder characterized by tingling, numbness, and burning pain in the outer side of the thigh. The disorder is caused by compression of the lateral femoral cutaneous nerve, a sensory nerve to the skin, as it exits the pelvis. People with the disorder often notice a patch of skin that is sensitive to touch and sometimes painful. Meralgia paresthetica should not be associated with weakness or radiating pain from the back.

More information from OMIM: 156220

Related Diseases for Meralgia Paraesthetica, Familial

Diseases related to Meralgia Paraesthetica, Familial via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 paresthesia 10.9
2 mononeuropathy 10.9
3 radiculopathy 10.8
4 neuropathy 10.7
5 pain agnosia 10.5
6 peripheral nervous system disease 10.5
7 alopecia 10.5
8 back pain 10.5
9 body mass index quantitative trait locus 11 10.4
10 body mass index quantitative trait locus 9 10.4
11 body mass index quantitative trait locus 8 10.4
12 body mass index quantitative trait locus 1 10.4
13 body mass index quantitative trait locus 4 10.4
14 body mass index quantitative trait locus 10 10.4
15 body mass index quantitative trait locus 7 10.4
16 body mass index quantitative trait locus 12 10.4
17 body mass index quantitative trait locus 14 10.4
18 body mass index quantitative trait locus 18 10.4
19 body mass index quantitative trait locus 19 10.4
20 body mass index quantitative trait locus 20 10.4
21 neuritis 10.4
22 neuroma 10.4
23 appendicitis 10.4
24 chronic pain 10.4
25 carpal tunnel syndrome 10.2
26 lipomatosis, multiple 10.2
27 spondylolisthesis 10.2
28 paine syndrome 10.2
29 slowed nerve conduction velocity, autosomal dominant 10.2
30 leukemia, acute lymphoblastic 10.2
31 leptin deficiency or dysfunction 10.2
32 lymphoma 10.2
33 scoliosis 10.2
34 idiopathic scoliosis 10.2
35 pelvic inflammatory disease 10.2
36 pleomorphic lipoma 10.2
37 lymphocytic leukemia 10.2
38 hypothyroidism 10.2
39 thrombophlebitis 10.2
40 liver disease 10.2
41 femoral neuropathy 10.2
42 nerve compression syndrome 10.2
43 spinal stenosis 10.2
44 osteochondrosis 10.2
45 osteoarthritis 10.2
46 diabetes mellitus 10.2
47 47,xyy 10.2
48 osteochondroma 10.2
49 tarlov cysts 10.2

Graphical network of the top 20 diseases related to Meralgia Paraesthetica, Familial:



Diseases related to Meralgia Paraesthetica, Familial

Symptoms & Phenotypes for Meralgia Paraesthetica, Familial

Human phenotypes related to Meralgia Paraesthetica, Familial:

31
# Description HPO Frequency HPO Source Accession
1 abnormality of the nervous system 31 HP:0000707

Symptoms via clinical synopsis from OMIM:

56
Neuro:
anesthesia and discomfort localized to nerve branch

Clinical features from OMIM:

156220

Drugs & Therapeutics for Meralgia Paraesthetica, Familial

Drugs for Meralgia Paraesthetica, Familial (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
2 Anti-Arrhythmia Agents Phase 3
3 Anesthetics, Local Phase 3
4 Sodium Channel Blockers Phase 3
5 Anesthetics Phase 3
6 Diuretics, Potassium Sparing Phase 3
7 Central Nervous System Depressants Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Comparison Between Ultrasound- and Neurostimulation-Guided Lateral Femoral Cutaneous Nerve Block Completed NCT02577510 Phase 3 Nerve Injection- Nerve Stimulator;Nerve Injection - Ultrasound
2 Conservative Treatment Versus Ultrasound Guided Injection in Management of Meralgia Paresthetica: A Randomized Controlled Trial Completed NCT04004052
3 Lidocaine 5% Patch (Lidoderm) for the Perioperative Prevention of Acute and Chronic Chest Pain Following Robotic Valve Surgery Completed NCT03120351 Lidoderm 5 % Topical Patch;Placebo patch
4 Pelvic Pain Treated With MR-guided Cryoanalgesia Recruiting NCT04046406
5 Examining the Impact of the Use of a Custom-fitted, FeelWell™ Compression Garment to Improve the Quality of Life of Individuals With a BMI ≥35 Recruiting NCT03798873
6 A Randomized, Prospective Clinical Trial Comparing the Use of Allograft Bone With Autograft Iliac Crest Bone in Anterior Cervical Spine Fusion Surgeries Not yet recruiting NCT03518164

Search NIH Clinical Center for Meralgia Paraesthetica, Familial

Genetic Tests for Meralgia Paraesthetica, Familial

Anatomical Context for Meralgia Paraesthetica, Familial

MalaCards organs/tissues related to Meralgia Paraesthetica, Familial:

40
Skin, Bone, Spinal Cord, Liver, Uterus, Testes

Publications for Meralgia Paraesthetica, Familial

Articles related to Meralgia Paraesthetica, Familial:

(show top 50) (show all 344)
# Title Authors PMID Year
1
Familial occurrence of meralgia paraesthetica. 56
629666 1978
2
[Research progress on meralgia paresthetica after posterior spine surgery]. 61
31694139 2019
3
Meralgia paresthetica: finding an effective cure. 61
31566048 2019
4
Feasibility and Safety of Outpatient Lumbar Microscopic Discectomy in a Developing Country. 61
31154705 2019
5
Inguinal segmental nerve conduction of the lateral femoral cutaneous nerve in healthy controls and in patients with meralgia paresthetica. 61
31227403 2019
6
Adding an ultrasound scan before the injection reveals a rare cause of meralgia paresthetica: inguinal lymphadenomegaly. 61
31393269 2019
7
Retrospective Long-Term Follow-Up Survival Analysis of the Management of Osteonecrosis of the Femoral Head With Pedicled Vascularized Iliac Bone Graft Transfer. 61
31031157 2019
8
The Correlation of Meralgia Paresthetica and Spina Surgery in Prone Position. 61
31736033 2019
9
Is Triamcinolone an Easy and Efficient Way to Treat Meralgia Paresthetica? A Cohort Study. 61
31359943 2019
10
Laparoscopic-Assisted Intra-Abdominal Section of the Lateral Femoral Cutaneous Nerve for Meralgia Paresthetica Following Anterior Hip Arthroplasty. 61
30898736 2019
11
Pelvic osteochondroma causing meralgia paresthetica. 61
31347595 2019
12
Surgical options for meralgia paresthetica: long-term outcomes in 13 cases. 61
30451004 2019
13
Histopathologic changes inside the lateral femoral cutaneous nerve obtained from patients with persistent symptoms of meralgia paresthetica. 61
30560377 2019
14
Meralgia paresthetica: Now showing on 3T magnetic resonance neurography. 61
31754539 2019
15
Spinal Cord Stimulation for Restless Legs Syndrome: Case Series and Mechanistic Hypothesis. 61
30947223 2019
16
Alopecia in Meralgia Paresthetica. 61
30591200 2018
17
Dynamic decompression of the lateral femoral cutaneous nerve to treat meralgia paresthetica: technique and results. 61
30544337 2018
18
Lateral Femoral Cutaneous Nerve Decompression Guided by Preoperative Ultrasound Mapping. 61
30723651 2018
19
Deep Decompression of the Lateral Femoral Cutaneous Nerve Under Local Anesthesia. 61
30017766 2018
20
Sartorius muscle tear presenting as acute meralgia paresthetica. 61
29864729 2018
21
Extreme lateral lumbar interbody fusion (XLIF) in the management of degenerative scoliosis: a retrospective case series. 61
30547126 2018
22
Surgical decompression of the lateral femoral cutaneous nerve (LFCN) for Meralgia paresthetica treatment: Experimental or state of the art? A single-center outcome analysis. 61
30113491 2018
23
Meralgia paresthetica after incorrect crutch usage in a boy with a wide abdomen. 61
30160036 2018
24
Extended duration pulsed radiofrequency for the management of refractory meralgia paresthetica: a series of five cases. 61
30013736 2018
25
Can a Tarlov cyst radiculopathy simulate meralgia paresthetica? 61
27659177 2018
26
Efficacy of Pulsed Radiofrequency Stimulation in Patients with Peripheral Neuropathic Pain: A Narrative Review. 61
29871378 2018
27
Transposition of the lateral femoral cutaneous nerve. 61
29652230 2018
28
Meralgia Paresthetica After Spine Surgery on the Jackson Table. 61
29135610 2018
29
Safety and Utility of the Drainless Abdominoplasty in the Post-Bariatric Surgery Patient. 61
29319578 2018
30
Corticosteroid Injection for an Orthopedic Complaint in a Female with Gestational Diabetes. 61
29305780 2018
31
Meralgia paresthetica. 61
30442009 2018
32
Ultrasound-Guided Diagnosis and Injection of the Lateral Femoral Cutaneous Nerve with an Anatomical Variation. 61
28112483 2017
33
Treatment of Femoroacetabular Impingement with a Mini-open Direct Anterior Approach. 61
29200484 2017
34
Correlation of Histopathology and Clinical Symptoms in Meralgia Paresthetica. 61
29279815 2017
35
An Unusual Case of Bilateral Meralgia Paresthetica Following Femoral Cannulations. 61
28955515 2017
36
Risk factor analysis for meralgia paresthetica: A hospital-based study in Taiwan. 61
28511974 2017
37
Preoperative Ultrasound-Guided Wire Localization of the Lateral Femoral Cutaneous Nerve. 61
28521342 2017
38
Evaluating the evidence: is neurolysis or neurectomy a better treatment for meralgia paresthetica? 61
28283866 2017
39
Anatomy of the lateral femoral cutaneous nerve relevant to clinical findings in meralgia paresthetica. 61
27543938 2017
40
[A Case of Meralgia Paresthetica Treated with Neurolysis]. 61
28490686 2017
41
Lateral femoral cutaneous nerve transposition: Renaissance of an old concept in the light of new anatomy. 61
28192874 2017
42
Live Donors of the Initial Observational Study of Uterus Transplantation-Psychological and Medical Follow-Up Until 1 Year After Surgery in the 9 Cases. 61
27941441 2017
43
The lateral femoral cutaneous nerve canal. 61
27104839 2017
44
Ultrasound therapy in iliopsoas hematoma. 61
28971177 2017
45
Load Carriage-Related Paresthesias (Part 2): Meralgia Paresthetica. 61
28285487 2017
46
Use of a trephine bur and curette for minimally invasive harvesting of particulate cancellous bone and marrow from the iliac crest: a case of alveolar ridge reconstruction. 61
27747693 2016
47
Technical feasibility of robot-assisted minimally-invasive neurolysis of the lateral cutaneous nerve of thigh: About a case. 61
27209566 2016
48
Smart device neuropathy. 61
27772742 2016
49
Ultrasound-guided alcohol neurolysis of lateral femoral cutaneous nerve for intractable meralgia paresthetica: a case series. 61
27867513 2016
50
Update on Ultrasound-Guided Interventional Procedures on Peripheral Nerves. 61
28002867 2016

Variations for Meralgia Paraesthetica, Familial

Expression for Meralgia Paraesthetica, Familial

Search GEO for disease gene expression data for Meralgia Paraesthetica, Familial.

Pathways for Meralgia Paraesthetica, Familial

GO Terms for Meralgia Paraesthetica, Familial

Sources for Meralgia Paraesthetica, Familial

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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