MCID: MRC003
MIFTS: 53

Mercury Poisoning

Categories: Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Mercury Poisoning

MalaCards integrated aliases for Mercury Poisoning:

Name: Mercury Poisoning 53 59
Mercury Intoxication 59
Mercury Toxicity 53
Mercurialism 59
Hydrargyria 59

Characteristics:

Orphanet epidemiological data:

59
mercury poisoning
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



Summaries for Mercury Poisoning

NIH Rare Diseases : 53 Mercury poisoning is a condition that occurs in people who are exposed to toxic levels of the element, mercury. There are three different forms of mercury that can cause health problems:Elemental mercury (also known as liquid mercury or quicksilver) can be found in glass thermometers, electrical switches, dental fillings and fluorescent light bulbs. This form of mercury is generally only harmful when small droplets become airborne and are inhaled. If this occurs, signs and symptoms of poisoning may include metallic taste, vomiting, difficulty breathing, coughing, and/or swollen, bleeding gums. In severe cases, long-term brain damage, permanent lung damage and even death may occur. Inorganic mercury is found in batteries, chemistry labs, and some disinfectants. This form of mercury is harmful when swallowed. Signs and symptoms of inorganic mercury poisoning vary based on the amount consumed, but may include burning in the stomach and throat; vomiting; and/or bloody diarrhea. Inorganic mercury can also affect the kidneys and brain if it enters the blood stream. Organic mercury can be found in fish. Some organisms convert fumes from burning coal into organic mercury. This form of mercury is harmful if inhaled, eaten, or placed on the skin for long periods of time. Long-term exposure to organic mercury may result in skin numbness or pain; tremor; inability to walk well; blindness; double vision; memory problems; seizures; or even death. Treatment is generally supportive and based on the signs and symptoms present in each person. Medications called chelators, which remove mercury and heavy metals from the body, are generally prescribed.

MalaCards based summary : Mercury Poisoning, also known as mercury intoxication, is related to acute kidney tubular necrosis and dermatitis. An important gene associated with Mercury Poisoning is B2M (Beta-2-Microglobulin), and among its related pathways/superpathways are Allograft rejection and Formation of Fibrin Clot (Clotting Cascade). The drug Chelating Agents has been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and brain, and related phenotypes are hypertension and seizures

Wikipedia : 76 Mercury poisoning is a type of metal poisoning due to exposure to mercury. Symptoms depend upon the... more...

Related Diseases for Mercury Poisoning

Diseases in the Mercury Poisoning family:

Infantile Mercury Poisoning

Diseases related to Mercury Poisoning via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 211)
# Related Disease Score Top Affiliating Genes
1 acute kidney tubular necrosis 29.9 B2M IL18
2 dermatitis 29.9 IL13 IL18
3 thrombosis 29.4 PLAT THBD
4 infantile mercury poisoning 12.4
5 erythromelalgia 11.2
6 young syndrome 11.1
7 muscular dystrophy, limb-girdle, autosomal recessive 1 11.0
8 muscular dystrophy-dystroglycanopathy , type b, 5 11.0
9 muscular dystrophy-dystroglycanopathy , type c, 5 11.0
10 muscular dystrophy-dystroglycanopathy , type b, 6 11.0
11 muscular dystrophy-dystroglycanopathy , type c, 4 11.0
12 muscular dystrophy-dystroglycanopathy , type b, 3 11.0
13 toxic encephalopathy 11.0
14 fetal methylmercury syndrome 10.5
15 omphalocele 10.3
16 exanthem 10.2
17 oral lichen planus 10.2
18 nephrotic syndrome 10.2
19 blood group--swann system 10.1
20 glomerulonephritis 10.1
21 autoimmune glomerulonephritis 10.1
22 streptococcal group a invasive disease 10.1
23 hepatitis 10.1
24 hepatitis b 10.1
25 isolated optic neuritis 10.0
26 pleural tuberculosis 10.0 B2M IL18
27 latex allergy 10.0 IL13 IL18
28 acute kidney failure 10.0 B2M IL18
29 amyotrophic lateral sclerosis 1 10.0
30 membranous nephropathy 10.0
31 lateral sclerosis 10.0
32 syphilis 10.0
33 eosinophilic gastritis 10.0 IL13 IL18
34 mycoplasma pneumoniae pneumonia 10.0 IL13 IL18
35 bone marrow cancer 10.0 B2M THBD
36 lipoid nephrosis 10.0
37 proteasome-associated autoinflammatory syndrome 1 10.0 IL13 IL18
38 hemophagocytic lymphohistiocytosis 9.9 B2M IL18
39 rheumatic disease 9.9 IL18 THBD
40 postaxial acrofacial dysostosis 9.9 PLAT THBD
41 marantic endocarditis 9.9 PLAT THBD
42 sarcoidosis 1 9.9 IL13 IL18
43 eisenmenger syndrome 9.9 PLAT THBD
44 grange syndrome 9.9 PLAT THBD
45 dysfibrinogenemia 9.9 PLAT THBD
46 creutzfeldt-jakob disease 9.9
47 pheochromocytoma 9.9
48 autism 9.9
49 aging 9.9
50 myocardial infarction 9.9

Graphical network of the top 20 diseases related to Mercury Poisoning:



Diseases related to Mercury Poisoning

Symptoms & Phenotypes for Mercury Poisoning

Human phenotypes related to Mercury Poisoning:

59 32 (show all 21)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypertension 59 32 frequent (33%) Frequent (79-30%) HP:0000822
2 seizures 59 32 frequent (33%) Frequent (79-30%) HP:0001250
3 tremor 59 32 frequent (33%) Frequent (79-30%) HP:0001337
4 hypotension 59 32 frequent (33%) Frequent (79-30%) HP:0002615
5 hypokalemia 59 32 frequent (33%) Frequent (79-30%) HP:0002900
6 generalized muscle weakness 59 32 frequent (33%) Frequent (79-30%) HP:0003324
7 respiratory distress 59 32 frequent (33%) Frequent (79-30%) HP:0002098
8 dystonia 59 32 frequent (33%) Frequent (79-30%) HP:0001332
9 anorexia 59 32 frequent (33%) Frequent (79-30%) HP:0002039
10 respiratory failure 59 32 frequent (33%) Frequent (79-30%) HP:0002878
11 episodic abdominal pain 59 32 frequent (33%) Frequent (79-30%) HP:0002574
12 insomnia 59 32 frequent (33%) Frequent (79-30%) HP:0100785
13 acute kidney injury 59 32 frequent (33%) Frequent (79-30%) HP:0001919
14 tachycardia 59 32 frequent (33%) Frequent (79-30%) HP:0001649
15 confusion 59 32 frequent (33%) Frequent (79-30%) HP:0001289
16 nausea 59 32 frequent (33%) Frequent (79-30%) HP:0002018
17 loss of consciousness 59 32 frequent (33%) Frequent (79-30%) HP:0007185
18 interstitial pneumonitis 59 32 frequent (33%) Frequent (79-30%) HP:0006515
19 abnormality of the cerebral white matter 59 32 frequent (33%) Frequent (79-30%) HP:0002500
20 episodic vomiting 59 32 frequent (33%) Frequent (79-30%) HP:0002572
21 dyspnea 59 Frequent (79-30%)

GenomeRNAi Phenotypes related to Mercury Poisoning according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between PTTG1-/- and PTTG1+/+ GR00255-A-4 8.8 B2M IL13 THBD

MGI Mouse Phenotypes related to Mercury Poisoning:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.88 B2M IL13 IL18 PLAT THBD
2 digestive/alimentary MP:0005381 9.85 B2M IL13 IL18 PLAT THBD
3 growth/size/body region MP:0005378 9.83 B2M IL13 IL18 PLAT THBD
4 hematopoietic system MP:0005397 9.8 B2M IL13 IL18 PLAT THBD
5 homeostasis/metabolism MP:0005376 9.77 B2M IL13 IL18 PLAT THBD
6 immune system MP:0005387 9.72 B2M IL13 IL18 PLAT THBD
7 integument MP:0010771 9.65 B2M IL13 IL18 PLAT THBD
8 mortality/aging MP:0010768 9.55 B2M IL13 IL18 PLAT THBD
9 nervous system MP:0003631 9.35 B2M IL13 IL18 PLAT THBD
10 reproductive system MP:0005389 8.92 B2M IL13 PLAT THBD

Drugs & Therapeutics for Mercury Poisoning

Drugs for Mercury Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Chelating Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pilot Proof of Concept Study of NBMI Treatment of Mercury Intoxication Completed NCT02486289 Phase 2 Emeramide;Placebo
2 Environmental Contaminants and Infant Development Completed NCT00013858

Search NIH Clinical Center for Mercury Poisoning

Genetic Tests for Mercury Poisoning

Anatomical Context for Mercury Poisoning

MalaCards organs/tissues related to Mercury Poisoning:

41
Skin, Kidney, Brain, Lung, Bone, Liver, Heart

Publications for Mercury Poisoning

Articles related to Mercury Poisoning:

(show top 50) (show all 464)
# Title Authors Year
1
Fixed drug eruption due To 2,3-dimercapto-1-propanesulfonic acid (DMPS) treatment for mercury poisoning: a rare adverse effect. ( 29912651 )
2018
2
Mercury poisoning in a fisherman working on a pelagic fishing vessel due to excessive tuna consumption. ( 29093364 )
2018
3
Mercury Intoxication as a Rare Cause of Membranous Nephropathy in a Child. ( 30041877 )
2018
4
Mercury Poisoning in a Toddler from Home Contamination due to Skin-Lightening Cream. ( 29395180 )
2018
5
Effects of diphenyl diselenide diet on a model of mercury poisoning. ( 30353476 )
2018
6
Pediatric Mercury Intoxication Mimicking Pheochromocytoma ( 30226199 )
2018
7
Assessing mercury intoxication in isolated/remote populations: Increased S100B mRNA in blood in exposed riverine inhabitants of the Amazon. ( 30076900 )
2018
8
Natural Phytotherapeutic Antioxidants in the Treatment of Mercury Intoxication-A Review. ( 30276132 )
2018
9
Role for apolipoprotein E in neurodegeneration and mercury intoxication. ( 28930615 )
2018
10
Efficacy of N,N'bis-(2-mercaptoethyl) isophthalamide on mercury intoxication: a randomized controlled trial. ( 29444690 )
2018
11
The interwoven history of mercury poisoning in Ontario and Japan. ( 28385869 )
2017
12
Vulnerability associated with "symptoms similar to those of mercury poisoning" in communities from Xingu River, Amazon basin. ( 28578479 )
2017
13
An Enigmatic Case of Acute Mercury Poisoning: Clinical, Immunological Findings and Platelet Function. ( 29033890 )
2017
14
Mercury poisoning through intravenous administration: Two case reports with literature review. ( 29145289 )
2017
15
Assessment and management of elemental mercury poisoning-a case report. ( 28174636 )
2017
16
Cases of acute mercury poisoning by mercury vapor exposure during the demolition of a fluorescent lamp factory. ( 28649389 )
2017
17
MiR-92a and miR-486 are potential diagnostic biomarkers for mercury poisoning and jointly sustain NF-I_B activity in mercury toxicity. ( 29167424 )
2017
18
Mercury Poisoning at a Home Day Care Center - Hillsborough County, Florida, 2015. ( 28472024 )
2017
19
Mercury poisoning in the Grassy Narrows First Nation: history not completed. ( 28584045 )
2017
20
Is Chelation Therapy Efficient for the Treatment of Intravenous Metallic Mercury Intoxication? ( 27911474 )
2017
21
Disability Weights for Chronic Mercury Intoxication Resulting from Gold Mining Activities: Results from an Online Pairwise Comparisons Survey. ( 28075395 )
2017
22
Characteristics of Mercury Intoxication Induced by Skin-lightening Products. ( 29237936 )
2017
23
Acute mercury poisoning from occult ritual use. ( 28913479 )
2016
24
Mercury poisoning caused by Chinese folk prescription (CFP): A case report and analysis of both CFP and quackery. ( 27858849 )
2016
25
Occupational Metallic Mercury Poisoning in Gilders. ( 27112720 )
2016
26
Mercury Poisoning in Operational Settings among Gilders. ( 27651086 )
2016
27
The interwoven history of mercury poisoning in Ontario and Japan. ( 27920011 )
2016
28
Saint Ioannis Lampadistis, the first possible case of blindness due to organic mercury poisoning in history. ( 27686425 )
2016
29
Acute Mercury Poisoning in a Group of School Children. ( 27977534 )
2016
30
Fabrication of a mercaptoacetic acid pillar[5]arene assembled nanochannel: a biomimetic gate for mercury poisoning. ( 29997814 )
2016
31
Inorganic mercury intoxication: A case report. ( 26778587 )
2016
32
Evaluation of mercury exposure level, clinical diagnosis and treatment for mercury intoxication. ( 26807265 )
2016
33
Essential Indicators Identifying Chronic Inorganic Mercury Intoxication: Pooled Analysis across Multiple Cross-Sectional Studies. ( 27575533 )
2016
34
Alternative drugs go global: possible lead and/ or mercury intoxication from imported natural health products and a need for scientifically evaluated poisoning monitoring from environmental exposures. ( 27833648 )
2016
35
Notes from the Field: Acute Mercury Poisoning After Home Gold and Silver Smelting--Iowa, 2014. ( 26678598 )
2015
36
Mercury poisoning in two 13-year-old twin sisters. ( 26109979 )
2015
37
Mercury poisoning presenting as sporadic creutzfeldt-jakob disease: a case report. ( 25775335 )
2015
38
Effect of propolis on erythrocyte rheology in experimental mercury intoxication in rats. ( 25903179 )
2015
39
Selenium as an antidote in the treatment of mercury intoxication. ( 25947386 )
2015
40
Can Urtica dioica supplementation attenuate mercury intoxication in Wistar rats? ( 27047060 )
2015
41
Current approaches of the management of mercury poisoning: need of the hour. ( 24888360 )
2014
42
Mercury Poisoning as a Cause of Intracranial Hypertension. ( 25122110 )
2014
43
Subacute motor neuron hyperexcitability with mercury poisoning: a case series and literature review. ( 25227723 )
2014
44
Mercury poisoning: a case of a complex neuropsychiatric illness. ( 25756767 )
2014
45
Acute mercury poisoning presenting as fever of unknown origin in an adult woman: a case report. ( 25084829 )
2014
46
Mercury poisoning dentistry: high-level indoor air mercury contamination at selected dental sites. ( 24552960 )
2014
47
Serum biochemical markers of central nerve system damage in children with acute elemental mercury intoxicatıon. ( 24400932 )
2014
48
Response to letter to editor regarding "Serum biochemical markers of central nerve system damage in children with acute elemental mercury intoxicatıon" in Clinical Toxicology 2014: (doi: 10.3109/15563650.2013.860986). ( 24628248 )
2014
49
Elements of the B cell signalosome are differentially affected by mercury intoxication. ( 24876949 )
2014
50
Long-term effects of mercury intoxication in the peripheral nervous system. ( 25098486 )
2014

Variations for Mercury Poisoning

Expression for Mercury Poisoning

Search GEO for disease gene expression data for Mercury Poisoning.

Pathways for Mercury Poisoning

Pathways related to Mercury Poisoning according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.28 B2M IL13 IL18
2
Show member pathways
11.71 PLAT THBD
3 11.64 PLAT THBD
4 11.62 PLAT THBD
5
Show member pathways
11.56 IL13 PLAT
6 11.49 IL13 IL18
7
Show member pathways
11.46 B2M IL18
8 11.22 IL13 IL18
9 11.11 IL13 IL18
10 10.85 IL13 IL18
11 10.46 IL13 IL18
12 10.07 IL13 IL18

GO Terms for Mercury Poisoning

Cellular components related to Mercury Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.46 B2M IL13 IL18 PLAT
2 cell surface GO:0009986 9.13 B2M PLAT THBD
3 extracellular space GO:0005615 9.02 B2M IL13 IL18 PLAT THBD

Biological processes related to Mercury Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.32 IL13 THBD
2 positive regulation of cold-induced thermogenesis GO:0120162 9.26 IL13 IL18
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.16 IL13 IL18
4 immune response GO:0006955 9.13 B2M IL13 IL18
5 positive regulation of smooth muscle cell proliferation GO:0048661 8.62 IL13 IL18

Sources for Mercury Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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