MCID: MRC003
MIFTS: 48

Mercury Poisoning

Categories: Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Mercury Poisoning

MalaCards integrated aliases for Mercury Poisoning:

Name: Mercury Poisoning 52 58 17
Mercury Intoxication 58
Mercury Toxicity 52
Mercurialism 58
Hydrargyria 58

Characteristics:

Orphanet epidemiological data:

58
mercury poisoning
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



Summaries for Mercury Poisoning

NIH Rare Diseases : 52 Mercury poisoning is a condition that occurs in people who are exposed to toxic levels of the element, mercury . There are three different forms of mercury that can cause health problems: Elemental mercury (also known as liquid mercury or quicksilver) can be found in glass thermometers, electrical switches, dental fillings and fluorescent light bulbs. This form of mercury is generally only harmful when small droplets become airborne and are inhaled. If this occurs, signs and symptoms of poisoning may include metallic taste, vomiting, difficulty breathing, coughing, and/or swollen, bleeding gums. In severe cases, long-term brain damage, permanent lung damage and even death may occur. Inorganic mercury is found in batteries, chemistry labs, and some disinfectants. This form of mercury is harmful when swallowed. Signs and symptoms of inorganic mercury poisoning vary based on the amount consumed, but may include burning in the stomach and throat; vomiting; and/or bloody diarrhea. Inorganic mercury can also affect the kidneys and brain if it enters the blood stream. Organic mercury can be found in fish. Some organisms convert fumes from burning coal into organic mercury. This form of mercury is harmful if inhaled, eaten, or placed on the skin for long periods of time. Long-term exposure to organic mercury may result in skin numbness or pain; tremor; inability to walk well; blindness; double vision; memory problems; seizures ; or even death. Treatment is generally supportive and based on the signs and symptoms present in each person. Medications called chelators, which remove mercury and heavy metals from the body, are generally prescribed.

MalaCards based summary : Mercury Poisoning, also known as mercury intoxication, is related to hypertension, essential and acute kidney failure. An important gene associated with Mercury Poisoning is B2M (Beta-2-Microglobulin), and among its related pathways/superpathways are Fluid shear stress and atherosclerosis and Microglia Activation During Neuroinflammation: Overview. The drugs Chelating Agents and N,N'-Bis(2-mercaptoethyl)isophthalamide have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and brain, and related phenotypes are hypertension and seizures

Wikipedia : 74 Mercury poisoning is a type of metal poisoning due to exposure to mercury. Symptoms depend upon the... more...

Related Diseases for Mercury Poisoning

Diseases in the Mercury Poisoning family:

Infantile Mercury Poisoning

Diseases related to Mercury Poisoning via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 666)
# Related Disease Score Top Affiliating Genes
1 hypertension, essential 30.6 THBD PLAT IL18 B2M
2 acute kidney failure 30.3 IL18 B2M
3 pulmonary embolism 29.6 THBD PLAT
4 thrombophilia due to thrombin defect 29.6 THBD PLAT
5 skin disease 29.3 IL18 IL13 B2M
6 kidney disease 29.3 THBD IL18 B2M
7 gingivitis 29.3 PLAT IL18
8 peritonitis 29.1 IL18 B2M
9 peripheral vascular disease 29.0 THBD PLAT IL18
10 pre-eclampsia 28.9 THBD PLAT IL18
11 atherosclerosis susceptibility 28.8 THBD PLAT IL18
12 vascular disease 28.7 THBD PLAT IL18
13 thrombocytopenia 28.7 THBD PLAT IL18
14 systemic lupus erythematosus 28.2 THBD IL18 IL13 B2M
15 diabetes mellitus 27.9 THBD PLAT IL18 B2M
16 malaria 27.5 THBD PLAT IL18 IL13 B2M
17 infantile mercury poisoning 12.5
18 tremor 11.7
19 erythromelalgia 11.7
20 young syndrome 11.3
21 muscular dystrophy, limb-girdle, autosomal recessive 1 11.1
22 muscular dystrophy-dystroglycanopathy , type b, 5 11.1
23 muscular dystrophy-dystroglycanopathy , type c, 5 11.1
24 muscular dystrophy-dystroglycanopathy , type b, 6 11.1
25 muscular dystrophy-dystroglycanopathy , type c, 4 11.1
26 muscular dystrophy-dystroglycanopathy , type b, 3 11.1
27 fetal methylmercury syndrome 10.6
28 dermatitis 10.5
29 triiodothyronine receptor auxiliary protein 10.5
30 allergic hypersensitivity disease 10.5
31 congestive heart failure 10.4
32 contact dermatitis 10.4
33 exanthem 10.4
34 hair whorl 10.3
35 ataxia and polyneuropathy, adult-onset 10.3
36 nephrotic syndrome 10.3
37 heart disease 10.3
38 allergic contact dermatitis 10.3
39 polyneuropathy 10.3
40 anuria 10.3
41 alzheimer disease 10.3
42 oral lichen planus 10.3
43 omphalocele 10.2
44 paresthesia 10.2
45 auditory neuropathy and optic atrophy 10.2
46 dumping syndrome 10.2
47 peripheral nervous system disease 10.2
48 neuropathy 10.2
49 47,xyy 10.2
50 autoimmune glomerulonephritis 10.1

Graphical network of the top 20 diseases related to Mercury Poisoning:



Diseases related to Mercury Poisoning

Symptoms & Phenotypes for Mercury Poisoning

Human phenotypes related to Mercury Poisoning:

58 31 (show all 21)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypertension 58 31 frequent (33%) Frequent (79-30%) HP:0000822
2 seizures 58 31 frequent (33%) Frequent (79-30%) HP:0001250
3 tremor 58 31 frequent (33%) Frequent (79-30%) HP:0001337
4 hypotension 58 31 frequent (33%) Frequent (79-30%) HP:0002615
5 hypokalemia 58 31 frequent (33%) Frequent (79-30%) HP:0002900
6 generalized muscle weakness 58 31 frequent (33%) Frequent (79-30%) HP:0003324
7 respiratory distress 58 31 frequent (33%) Frequent (79-30%) HP:0002098
8 dystonia 58 31 frequent (33%) Frequent (79-30%) HP:0001332
9 anorexia 58 31 frequent (33%) Frequent (79-30%) HP:0002039
10 abnormality of the cerebral white matter 58 31 frequent (33%) Frequent (79-30%) HP:0002500
11 respiratory failure 58 31 frequent (33%) Frequent (79-30%) HP:0002878
12 confusion 58 31 frequent (33%) Frequent (79-30%) HP:0001289
13 episodic abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002574
14 insomnia 58 31 frequent (33%) Frequent (79-30%) HP:0100785
15 acute kidney injury 58 31 frequent (33%) Frequent (79-30%) HP:0001919
16 tachycardia 58 31 frequent (33%) Frequent (79-30%) HP:0001649
17 nausea 58 31 frequent (33%) Frequent (79-30%) HP:0002018
18 episodic vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002572
19 loss of consciousness 58 31 frequent (33%) Frequent (79-30%) HP:0007185
20 interstitial pneumonitis 58 31 frequent (33%) Frequent (79-30%) HP:0006515
21 dyspnea 58 Frequent (79-30%)

GenomeRNAi Phenotypes related to Mercury Poisoning according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between PTTG1-/- and PTTG1+/+ GR00255-A-4 8.8 B2M IL13 THBD

MGI Mouse Phenotypes related to Mercury Poisoning:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 B2M IL13 IL18 PLAT THBD
2 digestive/alimentary MP:0005381 9.77 B2M IL13 IL18 PLAT THBD
3 growth/size/body region MP:0005378 9.72 B2M IL13 IL18 PLAT THBD
4 hematopoietic system MP:0005397 9.65 B2M IL13 IL18 PLAT THBD
5 immune system MP:0005387 9.55 B2M IL13 IL18 PLAT THBD
6 integument MP:0010771 9.35 B2M IL13 IL18 PLAT THBD
7 nervous system MP:0003631 9.02 B2M IL13 IL18 PLAT THBD

Drugs & Therapeutics for Mercury Poisoning

Drugs for Mercury Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Chelating Agents Phase 2
2 N,N'-Bis(2-mercaptoethyl)isophthalamide Phase 2
3 Vaccines Phase 1
4 Protective Agents Phase 1
5 Antidotes Phase 1
6 Unithiol Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Double-blinded, Randomized Controlled Trial to Evaluate the Efficacy, Safety, and Tolerability of N1, N3-bis-(2-Mercaptoethyl) Isophthalamide (NBMI) in the Reduction of Mercury Levels, in Subjects Exposed to Mercury in Atlántico, Colombia Not yet recruiting NCT04183595 Phase 2, Phase 3 (N1, N3-bis(2- mercaptoethyl)isophthalamide)
2 A Randomized, Placebo-controlled Study to Explore Safety, Dose and Efficacy of NBMI in a Mercury Intoxicated Population Completed NCT02486289 Phase 2 Emeramide;Placebo
3 Transdermal Absorption of DMPS and Its Effect on Urinary Mercury Excretion Completed NCT01059474 Phase 1 transdermal DMPS
4 Environmental Contaminants and Infant Development Completed NCT00013858

Search NIH Clinical Center for Mercury Poisoning

Genetic Tests for Mercury Poisoning

Anatomical Context for Mercury Poisoning

MalaCards organs/tissues related to Mercury Poisoning:

40
Kidney, Skin, Brain, Liver, Lung, Testes, Cortex

Publications for Mercury Poisoning

Articles related to Mercury Poisoning:

(show top 50) (show all 1459)
# Title Authors PMID Year
1
Nephrotic syndrome caused by exposures to skin-lightening cosmetic products containing inorganic mercury. 61
31314603 2020
2
Mercury Poisoning Presenting With Hypertension: Report of 2 Cases. 61
31051143 2019
3
Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease. 61
31521398 2019
4
Deforestation Due to Artisanal and Small-Scale Gold Mining Exacerbates Soil and Mercury Mobilization in Madre de Dios, Peru. 61
31825606 2019
5
The biochemistry of mercury toxicity. 61
31401179 2019
6
The thioredoxin system as a target for mercury compounds. 61
30447253 2019
7
Physiological and functional aspects of metal-binding protein associated with mercury in the liver tissue of pirarucu (Arapaima gigas) from the Brazilian Amazon. 61
31323548 2019
8
Exploring the applicability of nano-selenium for capture of mercury vapor: Paper based sorbent and a chemical modifier in graphite furnace atomic absorption spectrometry. 61
31522728 2019
9
Selenium protection against mercury toxicity on the male reproductive system of Clarias gariepinus. 61
31394254 2019
10
Physiological and molecular mechanisms underlying salicylic acid-mitigated mercury toxicity in lemon balm (Melissa officinalis L.). 61
31401333 2019
11
Broken thermometer in foot: a source of mercury poisoning. 61
31694474 2019
12
Influence of Feeding Substrates on the Presence of Toxic Metals (Cd, Pb, Ni, As, Hg) in Larvae of Tenebrio molitor: Risk Assessment for Human Consumption. 61
31801191 2019
13
Metalloproteomic approach of mercury-binding proteins in liver and kidney tissues of Plagioscion squamosissimus (corvina) and Colossoma macropomum (tambaqui) from Amazon region: Possible identification of mercury contamination biomarkers. 61
31812405 2019
14
A Minimal Membrane Metal Transport System: Dynamics and Energetics of mer Proteins. 61
31721253 2019
15
Acute Mercury Poisoning in a Group of School Children. 61
27977534 2019
16
Aluminum and vaccines: Current state of knowledge. 61
31611133 2019
17
Engineering a bioluminescent bioreporter from an environmentally sourced mercury-resistant Enterobacter cloacae strain for the detection of bioavailable mercury. 61
31336395 2019
18
Imaging Appearances following Oral and Parenteral Mercury Poisoning. 61
31561695 2019
19
A novel biological sulfur reduction process for mercury-contaminated wastewater treatment. 61
31154126 2019
20
Solvent-tailored Pd3P0.95 nano catalyst for amide-nitrile inter-conversion, the hydration of nitriles and transfer hydrogenation of the C[double bond, length as m-dash]O bond. 61
31180393 2019
21
Phenol-Rich Feijoa sellowiana (Pineapple Guava) Extracts Protect Human Red Blood Cells from Mercury-Induced Cellular Toxicity. 61
31336755 2019
22
Fixed drug eruption due To 2,3-dimercapto-1-propanesulfonic acid (DMPS) treatment for mercury poisoning: a rare adverse effect. 61
29912651 2019
23
Identification of Potential Long Noncoding RNA Biomarker of Mercury Compounds in Zebrafish Embryos. 61
30912647 2019
24
Assessment of potential mercury toxicity to native invertebrates in a high-gradient stream. 61
30724482 2019
25
Critical mercury concentration in tropical soils: Impact on plants and soil biological attributes. 61
30802662 2019
26
Membranous nephropathy due to chronic mercury poisoning from traditional Indian medicines: report of five cases. 61
30976402 2019
27
[Clinical characteristics, treatment and outcome of chronic mercury-related nephrotic syndrome]. 61
31177691 2019
28
Superoxide Dismutase and Pseudocatalase Increase Tolerance to Hg(II) in Thermus thermophilus HB27 by Maintaining the Reduced Bacillithiol Pool. 61
30940703 2019
29
Species and correlations between selenium and mercury in fishpond ecosystems. 61
30735276 2019
30
Determination of Hg in Farmed and Wild Atlantic Bluefin Tuna (Thunnus thynnus L.) Muscle. 61
30939866 2019
31
A Case of Accidental Mercury Intoxication. 61
30718027 2019
32
Disruption of selenium transport and function is a major contributor to mercury toxicity in zebrafish larvae. 61
30688331 2019
33
Criminal mercury vapor poisoning using heated tobacco product. 61
30178086 2019
34
Changes of 30 years in the recognized occupational diseases of Korea: Lessons from the system change perspective. 61
30741113 2019
35
Mercury Exposure and Poor Nutritional Status Reduce Response to Six Expanded Program on Immunization Vaccines in Children: An Observational Cohort Study of Communities Affected by Gold Mining in the Peruvian Amazon. 61
30795575 2019
36
Unusual complication of an Alaskan cruise: thinking outside the box. 61
30814099 2019
37
Elemental Analysis of Aging Human Pituitary Glands Implicates Mercury as a Contributor to the Somatopause. 61
31297094 2019
38
Autism spectrum disorder and mercury toxicity: use of genomic and epigenetic methods to solve the etiologic puzzle. 61
31342948 2019
39
Mechanisms of toxic cardiomyopathy. 61
30260248 2019
40
Cytoprotective effects of imidazole-based [S1] and [S2]-donor ligands against mercury toxicity: a bioinorganic approach. 61
30488926 2019
41
Metals in sardine and anchovy from Greek coastal areas: Public health risk and nutritional benefits assessment. 61
30366072 2019
42
Medicinal plants and natural products can play a significant role in mitigation of mercury toxicity. 61
31762676 2018
43
Effects of diphenyl diselenide diet on a model of mercury poisoning. 61
30353476 2018
44
A Comparison of Mercury Exposure from Seafood Consumption and Dental Amalgam Fillings in People with and without Amyotrophic Lateral Sclerosis (ALS): An International Online Case-Control Study. 61
30558238 2018
45
Structure/function relationships of the human mitochondrial ornithine/citrulline carrier by Cys site-directed mutagenesis. Relevance to mercury toxicity. 61
30121301 2018
46
Methylmercury alters the number and topography of NO-synthase positive neurons in embryonic retina: Protective effect of alpha-tocopherol. 61
30075186 2018
47
Chronic Neurological Disease Due to Methylmercury Poisoning. 61
30278852 2018
48
A Case of Mercury Toxicity Complicated by Acute Inflammatory Demyelinating Polyneuropathy. 61
30149783 2018
49
Lung Function Assessment as an Early Biomonitor of Mercury-Induced Health Disorders in Artisanal and Small-Scale Gold Mining Areas in Indonesia. 61
30405024 2018
50
Mercury Intoxication as a Rare Cause of Membranous Nephropathy in a Child. 61
30041877 2018

Variations for Mercury Poisoning

Expression for Mercury Poisoning

Search GEO for disease gene expression data for Mercury Poisoning.

Pathways for Mercury Poisoning

GO Terms for Mercury Poisoning

Cellular components related to Mercury Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.13 THBD PLAT B2M
2 extracellular space GO:0005615 9.02 THBD PLAT IL18 IL13 B2M

Biological processes related to Mercury Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cold-induced thermogenesis GO:0120162 9.26 IL18 IL13
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.16 IL18 IL13
3 immune response GO:0006955 9.13 IL18 IL13 B2M
4 positive regulation of smooth muscle cell proliferation GO:0048661 8.62 IL18 IL13

Sources for Mercury Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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