MCID: MRC003
MIFTS: 48

Mercury Poisoning

Categories: Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Mercury Poisoning

MalaCards integrated aliases for Mercury Poisoning:

Name: Mercury Poisoning 52 58 17
Mercury Intoxication 58
Mercury Toxicity 52
Mercurialism 58
Hydrargyria 58

Characteristics:

Orphanet epidemiological data:

58
mercury poisoning
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



Summaries for Mercury Poisoning

NIH Rare Diseases : 52 Mercury poisoning is a condition that occurs in people who are exposed to toxic levels of the element, mercury . There are three different forms of mercury that can cause health problems: Elemental mercury (also known as liquid mercury or quicksilver) can be found in glass thermometers, electrical switches, dental fillings and fluorescent light bulbs. This form of mercury is generally only harmful when small droplets become airborne and are inhaled. If this occurs, signs and symptoms of poisoning may include metallic taste, vomiting, difficulty breathing, coughing, and/or swollen, bleeding gums. In severe cases, long-term brain damage, permanent lung damage and even death may occur. Inorganic mercury is found in batteries, chemistry labs, and some disinfectants. This form of mercury is harmful when swallowed. Signs and symptoms of inorganic mercury poisoning vary based on the amount consumed, but may include burning in the stomach and throat; vomiting; and/or bloody diarrhea. Inorganic mercury can also affect the kidneys and brain if it enters the blood stream. Organic mercury can be found in fish. Some organisms convert fumes from burning coal into organic mercury. This form of mercury is harmful if inhaled, eaten, or placed on the skin for long periods of time. Long-term exposure to organic mercury may result in skin numbness or pain; tremor; inability to walk well; blindness; double vision; memory problems; seizures ; or even death. Treatment is generally supportive and based on the signs and symptoms present in each person. Medications called chelators, which remove mercury and heavy metals from the body, are generally prescribed.

MalaCards based summary : Mercury Poisoning, also known as mercury intoxication, is related to hypertension, essential and acute kidney failure. An important gene associated with Mercury Poisoning is B2M (Beta-2-Microglobulin), and among its related pathways/superpathways are Complement and coagulation cascades and Fluid shear stress and atherosclerosis. The drugs Chelating Agents and N,N'-Bis(2-mercaptoethyl)isophthalamide have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and brain, and related phenotypes are hypokalemia and generalized muscle weakness

Wikipedia : 74 Mercury poisoning is a type of metal poisoning due to exposure to mercury. Symptoms depend upon the... more...

Related Diseases for Mercury Poisoning

Diseases in the Mercury Poisoning family:

Infantile Mercury Poisoning

Diseases related to Mercury Poisoning via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 671)
# Related Disease Score Top Affiliating Genes
1 hypertension, essential 30.7 THBD PLAT IL18 B2M
2 acute kidney failure 30.3 IL18 B2M
3 acute kidney tubular necrosis 29.8 IL18 B2M
4 brucellosis 29.7 IL18 IL13
5 pulmonary embolism 29.7 THBD PLAT
6 thrombophilia due to thrombin defect 29.6 THBD PLAT
7 kidney disease 29.4 THBD IL18 B2M
8 skin disease 29.4 IL18 IL13 B2M
9 meningitis 29.4 IL18 IL13
10 gingivitis 29.3 PLAT IL18
11 peritonitis 29.2 IL18 B2M
12 bone inflammation disease 29.1 IL18 IL13
13 peripheral vascular disease 29.0 THBD PLAT IL18
14 cerebral palsy 28.9 PLAT IL18 IL13
15 pre-eclampsia 28.9 THBD PLAT IL18
16 lymphopenia 28.8 IL18 B2M
17 diabetes mellitus, type i 28.8 IL18 IL13 B2M
18 atherosclerosis susceptibility 28.8 THBD PLAT IL18
19 pulmonary fibrosis, idiopathic 28.8 THBD IL18 IL13
20 vascular disease 28.7 THBD PLAT IL18
21 thrombocytopenia 28.7 THBD PLAT IL18
22 systemic lupus erythematosus 28.2 THBD IL18 IL13 B2M
23 diabetes mellitus 27.9 THBD PLAT IL18 B2M
24 malaria 27.4 THBD PLAT IL18 IL13 B2M
25 infantile mercury poisoning 12.5
26 tremor 11.8
27 erythromelalgia 11.7
28 young syndrome 11.3
29 muscular dystrophy, limb-girdle, autosomal recessive 1 11.1
30 muscular dystrophy-dystroglycanopathy , type b, 5 11.1
31 muscular dystrophy-dystroglycanopathy , type c, 5 11.1
32 muscular dystrophy-dystroglycanopathy , type b, 6 11.1
33 muscular dystrophy-dystroglycanopathy , type c, 4 11.1
34 muscular dystrophy-dystroglycanopathy , type b, 3 11.1
35 fetal methylmercury syndrome 10.6
36 dermatitis 10.5
37 triiodothyronine receptor auxiliary protein 10.5
38 allergic hypersensitivity disease 10.5
39 contact dermatitis 10.5
40 congestive heart failure 10.5
41 exanthem 10.4
42 hair whorl 10.3
43 ataxia and polyneuropathy, adult-onset 10.3
44 nephrotic syndrome 10.3
45 allergic contact dermatitis 10.3
46 heart disease 10.3
47 alzheimer disease 10.3
48 polyneuropathy 10.3
49 anuria 10.3
50 oral lichen planus 10.3

Graphical network of the top 20 diseases related to Mercury Poisoning:



Diseases related to Mercury Poisoning

Symptoms & Phenotypes for Mercury Poisoning

Human phenotypes related to Mercury Poisoning:

58 31 (show all 22)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypokalemia 58 31 frequent (33%) Frequent (79-30%) HP:0002900
2 generalized muscle weakness 58 31 frequent (33%) Frequent (79-30%) HP:0003324
3 tremor 58 31 frequent (33%) Frequent (79-30%) HP:0001337
4 hypertension 58 31 frequent (33%) Frequent (79-30%) HP:0000822
5 anorexia 58 31 frequent (33%) Frequent (79-30%) HP:0002039
6 insomnia 58 31 frequent (33%) Frequent (79-30%) HP:0100785
7 dystonia 58 31 frequent (33%) Frequent (79-30%) HP:0001332
8 respiratory failure 58 31 frequent (33%) Frequent (79-30%) HP:0002878
9 tachycardia 58 31 frequent (33%) Frequent (79-30%) HP:0001649
10 respiratory distress 58 31 frequent (33%) Frequent (79-30%) HP:0002098
11 hypotension 58 31 frequent (33%) Frequent (79-30%) HP:0002615
12 abnormality of the cerebral white matter 58 31 frequent (33%) Frequent (79-30%) HP:0002500
13 confusion 58 31 frequent (33%) Frequent (79-30%) HP:0001289
14 loss of consciousness 58 31 frequent (33%) Frequent (79-30%) HP:0007185
15 acute kidney injury 58 31 frequent (33%) Frequent (79-30%) HP:0001919
16 interstitial pneumonitis 58 31 frequent (33%) Frequent (79-30%) HP:0006515
17 episodic abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002574
18 episodic vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002572
19 nausea 58 31 frequent (33%) Frequent (79-30%) HP:0002018
20 seizure 31 frequent (33%) HP:0001250
21 seizures 58 Frequent (79-30%)
22 dyspnea 58 Frequent (79-30%)

GenomeRNAi Phenotypes related to Mercury Poisoning according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between PTTG1-/- and PTTG1+/+ GR00255-A-4 8.8 B2M IL13 THBD

MGI Mouse Phenotypes related to Mercury Poisoning:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 B2M IL13 IL18 PLAT THBD
2 digestive/alimentary MP:0005381 9.77 B2M IL13 IL18 PLAT THBD
3 growth/size/body region MP:0005378 9.72 B2M IL13 IL18 PLAT THBD
4 hematopoietic system MP:0005397 9.65 B2M IL13 IL18 PLAT THBD
5 immune system MP:0005387 9.55 B2M IL13 IL18 PLAT THBD
6 integument MP:0010771 9.35 B2M IL13 IL18 PLAT THBD
7 nervous system MP:0003631 9.02 B2M IL13 IL18 PLAT THBD

Drugs & Therapeutics for Mercury Poisoning

Drugs for Mercury Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Chelating Agents Phase 2
2 N,N'-Bis(2-mercaptoethyl)isophthalamide Phase 2
3 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Double-blinded, Randomized Controlled Trial to Evaluate the Efficacy, Safety, and Tolerability of N1, N3-bis-(2-Mercaptoethyl) Isophthalamide (NBMI) in the Reduction of Mercury Levels, in Subjects Exposed to Mercury in Atlántico, Colombia Not yet recruiting NCT04183595 Phase 2, Phase 3 (N1, N3-bis(2- mercaptoethyl)isophthalamide)
2 A Randomized, Placebo-controlled Study to Explore Safety, Dose and Efficacy of NBMI in a Mercury Intoxicated Population Completed NCT02486289 Phase 2 Emeramide;Placebo
3 Transdermal Absorption of DMPS and Its Effect on Urinary Mercury Excretion Completed NCT01059474 Phase 1 transdermal DMPS
4 Environmental Contaminants and Infant Development Completed NCT00013858

Search NIH Clinical Center for Mercury Poisoning

Genetic Tests for Mercury Poisoning

Anatomical Context for Mercury Poisoning

MalaCards organs/tissues related to Mercury Poisoning:

40
Kidney, Skin, Brain, Liver, Lung, Testes, Cortex

Publications for Mercury Poisoning

Articles related to Mercury Poisoning:

(show top 50) (show all 1480)
# Title Authors PMID Year
1
Autoimmune Manifestations of Acute Mercury Toxicity. 61
32281400 2020
2
Warmer temperature increases mercury toxicity in a marine copepod. 61
32544748 2020
3
Survey of Methylmercury Exposures and Risk Factors Among Indigenous Communities in Guyana, South America. 61
32509405 2020
4
Mechanistic Investigations of Nickamine- catalyzed Hydrosilylation of Alkenes: Nickel Nanoparticles Are the Active Species. 61
32560749 2020
5
Acute Elemental Mercury Poisoning Masquerading as Fever and Rash. 61
32572678 2020
6
Effect of soil mercury pollution on ginger (Zingiber officinale Roscoe): Growth, product quality, health risks and silicon mitigation. 61
32199219 2020
7
Environmental Toxic Exposures Using Companion Animals as an Indicator of Human Toxicity: A Case Report and Discussion. 61
32532580 2020
8
The chemical species of mercury accumulated by Pseudomonas idrijaensis, a bacterium from a rock of the Idrija mercury mine, Slovenia. 61
32032872 2020
9
Bargain with the tooth fairy - The savings accounts for dental stem cells. 61
32333995 2020
10
Metalloproteomic approach of mercury-binding proteins in liver and kidney tissues of Plagioscion squamosissimus (corvina) and Colossoma macropomum (tambaqui) from Amazon region: Possible identification of mercury contamination biomarkers. 61
31812405 2020
11
Mercury, cadmium, copper, arsenic, and selenium measurements in the feathers of adult eastern brown pelicans (Pelecanus occidentalis carolinensis) and chicks in multiple breeding grounds in the northern Gulf of Mexico. 61
32297009 2020
12
Rethinking the Minamata Tragedy: What Mercury Species Was Really Responsible? 61
31951385 2020
13
Knowledge and Attitude of Dentists and Patients Toward Use and Health Safety of Dental Amalgam in Saudi Arabia. 61
32396969 2020
14
A Minimal Membrane Metal Transport System: Dynamics and Energetics of mer Proteins. 61
31721253 2020
15
All that glitters is not gold: Mercury poisoning in a family mimicking an infectious illness. 61
32151591 2020
16
[Heavy metals in the enviroment: Guillain-Barre like syndrome]. 61
31984709 2020
17
Aluminum and vaccines: Current state of knowledge. 61
31611133 2020
18
Mercury Poisoning From Skin Cream. 61
32044950 2020
19
Evaluation of Dietary Organic and Inorganic Mercury Threshold Levels on Induced Mercury Toxicity in a Marine Fish Model. 61
32121390 2020
20
Prenatal exposure to legacy contaminants and visual acuity in Canadian infants: a maternal-infant research on environmental chemicals study (MIREC-ID). 61
32028962 2020
21
Genomics of Detoxification: How Genomics can be Used for Targeting Potential Intervention and Prevention Strategies Including Nutrition for Environmentally Acquired Illness. 61
32027241 2020
22
Broken thermometer in foot: a source of mercury poisoning. 61
31694474 2020
23
An unusual cause of high density radiological opacities. 61
32383469 2020
24
Nephrotic syndrome caused by exposures to skin-lightening cosmetic products containing inorganic mercury. 61
31314603 2020
25
Changes of 30 years in the recognized occupational diseases of Korea: Lessons from the system change perspective. 61
30741113 2020
26
Deforestation Due to Artisanal and Small-Scale Gold Mining Exacerbates Soil and Mercury Mobilization in Madre de Dios, Peru. 61
31825606 2020
27
The biochemistry of mercury toxicity. 61
31401179 2019
28
Mercury Poisoning Presenting With Hypertension: Report of 2 Cases. 61
31051143 2019
29
Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease. 61
31521398 2019
30
A Hypothesis and Evidence That Mercury May be an Etiological Factor in Alzheimer's Disease. 61
31861093 2019
31
The thioredoxin system as a target for mercury compounds. 61
30447253 2019
32
Physiological and functional aspects of metal-binding protein associated with mercury in the liver tissue of pirarucu (Arapaima gigas) from the Brazilian Amazon. 61
31323548 2019
33
Exploring the applicability of nano-selenium for capture of mercury vapor: Paper based sorbent and a chemical modifier in graphite furnace atomic absorption spectrometry. 61
31522728 2019
34
Selenium protection against mercury toxicity on the male reproductive system of Clarias gariepinus. 61
31394254 2019
35
Physiological and molecular mechanisms underlying salicylic acid-mitigated mercury toxicity in lemon balm (Melissa officinalis L.). 61
31401333 2019
36
Influence of Feeding Substrates on the Presence of Toxic Metals (Cd, Pb, Ni, As, Hg) in Larvae of Tenebrio molitor: Risk Assessment for Human Consumption. 61
31801191 2019
37
Engineering a bioluminescent bioreporter from an environmentally sourced mercury-resistant Enterobacter cloacae strain for the detection of bioavailable mercury. 61
31336395 2019
38
Integrative Medicine Approach To Peripheral Neuropathy-Avoiding Pitfalls Of Ineffective Current Standards In Assessing Chronic Low-Grade Mercury Toxicity And Functional Musculoskeletal Lesions. 61
32549846 2019
39
Acute Mercury Poisoning in a Group of School Children. 61
27977534 2019
40
Imaging Appearances following Oral and Parenteral Mercury Poisoning. 61
31561695 2019
41
A novel biological sulfur reduction process for mercury-contaminated wastewater treatment. 61
31154126 2019
42
Solvent-tailored Pd3P0.95 nano catalyst for amide-nitrile inter-conversion, the hydration of nitriles and transfer hydrogenation of the C[double bond, length as m-dash]O bond. 61
31180393 2019
43
Phenol-Rich Feijoa sellowiana (Pineapple Guava) Extracts Protect Human Red Blood Cells from Mercury-Induced Cellular Toxicity. 61
31336755 2019
44
Fixed drug eruption due To 2,3-dimercapto-1-propanesulfonic acid (DMPS) treatment for mercury poisoning: a rare adverse effect. 61
29912651 2019
45
Identification of Potential Long Noncoding RNA Biomarker of Mercury Compounds in Zebrafish Embryos. 61
30912647 2019
46
Assessment of potential mercury toxicity to native invertebrates in a high-gradient stream. 61
30724482 2019
47
Critical mercury concentration in tropical soils: Impact on plants and soil biological attributes. 61
30802662 2019
48
Membranous nephropathy due to chronic mercury poisoning from traditional Indian medicines: report of five cases. 61
30976402 2019
49
[Clinical characteristics, treatment and outcome of chronic mercury-related nephrotic syndrome]. 61
31177691 2019
50
Superoxide Dismutase and Pseudocatalase Increase Tolerance to Hg(II) in Thermus thermophilus HB27 by Maintaining the Reduced Bacillithiol Pool. 61
30940703 2019

Variations for Mercury Poisoning

Expression for Mercury Poisoning

Search GEO for disease gene expression data for Mercury Poisoning.

Pathways for Mercury Poisoning

Pathways related to Mercury Poisoning according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.59 THBD PLAT
2 11.55 THBD PLAT
3 11.43 IL18 IL13
4
Show member pathways
11.37 IL18 B2M
5 11.16 IL18 IL13
6 10.85 IL18 IL13
7 10.46 IL18 IL13
8 10.07 IL18 IL13

GO Terms for Mercury Poisoning

Cellular components related to Mercury Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.33 THBD PLAT B2M
2 external side of plasma membrane GO:0009897 9.13 THBD IL13 B2M
3 extracellular space GO:0005615 9.02 THBD PLAT IL18 IL13 B2M

Biological processes related to Mercury Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cold-induced thermogenesis GO:0120162 9.26 IL18 IL13
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.16 IL18 IL13
3 immune response GO:0006955 9.13 IL18 IL13 B2M
4 positive regulation of smooth muscle cell proliferation GO:0048661 8.62 IL18 IL13

Sources for Mercury Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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